LOCUS       gnlProkkaECDENMBE_40   12658 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ECDENMBE_40.
ACCESSION   gnlProkkaECDENMBE_40
VERSION     gnlProkkaECDENMBE_40
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 08:07:55
            Original ID  :: gnl|Prokka|ECDENMBE_40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12658
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12658
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[2876:5696]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2877..5696
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..12658
                     /SMILES="NC(C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12658
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(2..97)
                     /locus_tag="ctg40_1"
                     /transl_table=11
                     /translation="MGSLSTVVGDEKLTSREDRIGPLFMYVQCDED"
     CDS             complement(267..1235)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 198.4; E-value: 3e-60)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_2"
                     /transl_table=11
                     /translation="MCGIACLVLSFISQDQWLVYAIVLTNVILAFMSTFSGPSYKAFTK
                     EIVKKDSISQLNSLLETTSTVIKVTIPMVAIFLYKLLGIHGVLLLDGLSFLIAALLIFF
                     IVPINEAVVTKEKMTFRGIINDLKIGFKYVYNHKSIFIIIVLSALVNFFLAAYNLLLPY
                     SNQMFGEISTGLYGTFLTAEAIGGFIGAILSSFVNKKLSSKKLMLFLSLSGLVLMLATP
                     FYIMFHNVIILAISPALFSLFLSIFNIQFFSIVQRDVDNEFLGRVFGIIFTVAILFMPI
                     GTGFFSVVLNPNNTFNLFIIGASITVLSLVFGILFKRYNMS"
     CDS             complement(1214..1477)
                     /locus_tag="ctg40_3"
                     /transl_table=11
                     /translation="MKDVKKKNILYLVSSKGVSRIGDTMFDFANNTFLAGINPTSLSLV
                     AVYQSLESVIGVLFNLFGGVFADSFKRKKLLLLQISCVVLLA"
     CDS             complement(1464..2693)
                     /locus_tag="ctg40_4"
                     /transl_table=11
                     /translation="MKILLNKYTPTLAKLNYLADQDAIVIAPLDTQKKYEKYLMKGNRL
                     PKIIYLEDYTLPKMISIIRESIDVDSIEEVLTLDEHYMWHAGFLNDYFKKKNSSYLVNS
                     LFQDKYLMRSVLFEIVPQPMFRLIETQKDIELFWKNTAGDKSIIKPRFGAACVGIKKYS
                     RGEQIPEKFINSQYIIEEYVDLQKMLTCDGYSQGSNIIRFYSHEYEELLLGTIGTSDEF
                     TVRTNSLYEKNIPFLRKIFSECSKVLKEFVNDYSIIPFHFEWFFDENKGEFVFCEVGKR
                     FGGGDIPNLIQRSFGVNIFEEFWENVFDNKELHPSTDLERPKFISATYCPYKKRGKLVS
                     APDMELFEWTDEIYVFSKVGEESDGITSVVEGDFIAIIVSETEEQHNQKLSKLRELSEQ
                     FIWEERFERR"
     CDS             complement(2877..5696)
                     /NRPS_PKS="Domain: AMP-binding (1-338). E-value: 9.6e-56.
                     Score: 180.9. Matches aSDomain:
                     nrpspksdomains_ctg40_5_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (439-505). E-value: 6.2e-17.
                     Score: 53.8. Matches aSDomain:
                     nrpspksdomains_ctg40_5_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     166.6; E-value: 1.2e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_5"
                     /sec_met_domain="AMP-binding (E-value: 3.4e-66, bitscore:
                     213.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-17, bitscore:
                     53.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHNENIIISFFSILKSNNTYVPFSTKTNFNRIKDSIDDLNINYL
                     ITDNYNFSTIQEEFKGNYIINIDDYLDISQIPSNYKKEIEDSETQDIVYIMHTSGSTGK
                     PKGVKVTVNNLNYITENVQRITPCDEDSTLLFMTPYTFDVSITEICGWVYNGGAVVCRD
                     LNSNTWFDDIREVLYKYNITHVAACPSVFLTMMNIYSNEINIFNNLKFVVLAGERFSLN
                     IHKVWKESNWSFRLFNAYGPTETTVYCTLYELSKESSYDEIPIGTPLQGVEYIIDENTS
                     ELLVSGQCITNGYLDYENTSKYFINVNDCLYYKTGDLVELNGGLLYFKGRNDKQIQLNG
                     MRVELGEIENRIEEIEYVDQSKVIYKNNKIIAFIKTKYFDEEYFKNYFSQNFEKHLIPN
                     NFHLVSEFPLNQSKKVDKDRLMYNFLDTEESDSMLNELELEIKDLFENVITIGKEKITK
                     NSNFFNLGGDSLSSVLLLMGLEERFNISITLSDIYNYPTIMQLSKYIDSLKKNKNIDDE
                     PKKNENIKIDINTMTAELKNVENYIYRSGQIVSKYETLHLQRVYYYDNFESFIEFEYVF
                     QKGEAFEVVVGLINDLIANVTMLRTSFVFEDDKLYFVEKAMENLDSMPIFDVSYQSIDY
                     ISDIKKNIRMILMDSRKEGGLLNSLILLKNDKQYTLIGLMDHSIADASTPATILEIISN
                     LKNGKKINFESTYEDYIKLIHKNNNMYEIMKSSFYQDLVKCGEDSEFEIKKMESSLNVY
                     KVDLESDAKSLSTQQINLFLAYNIGQYLLKLFNQHSIVIKCLVNGKDYLGTKYKYTLGD
                     FHTSIYIVVYKDENYLDYKKRVEDSIKTNYVEKVFRPAYVYGSNYPIKNNDQKLLKNSL
                     RHTTNTSIDFLGIIKEDDLERYTKSVKQSLYQLTQIDDTLYVTVYLVNNQLVIYTNKDF
                     LDFETFVKL"
     aSDomain        complement(4182..4379)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg40_5_PP-binding.1"
                     /evalue="6.20E-17"
                     /label="ctg40_5_PP-binding.1"
                     /locus_tag="ctg40_5"
                     /protein_end="505"
                     /protein_start="439"
                     /score="53.8"
                     /tool="antismash"
                     /translation="EIKDLFENVITIGKEKITKNSNFFNLGGDSLSSVLLLMGLEERFN
                     ISITLSDIYNYPTIMQLSKYI"
     aSModule        complement(4182..5693)
                     /complete
                     /domains="nrpspksdomains_ctg40_5_AMP-binding.1"
                     /domains="nrpspksdomains_ctg40_5_PP-binding.1"
                     /locus_tags="ctg40_5"
                     /monomer_pairings="Ala -> Ala"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(4650..4715)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg40_5_0002"
                     /evalue="3.60E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg40_5"
                     /protein_end="349"
                     /protein_start="327"
                     /score="25.7"
                     /tool="antismash"
                     /translation="FKGRNDKQIQLNGMRVELGEIE"
     aSDomain        complement(4683..5693)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg40_5_AMP-binding.1"
                     /evalue="9.60E-56"
                     /label="ctg40_5_AMP-binding.1"
                     /locus_tag="ctg40_5"
                     /protein_end="338"
                     /protein_start="1"
                     /score="180.9"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="EHNENIIISFFSILKSNNTYVPFSTKTNFNRIKDSIDDLNINYLI
                     TDNYNFSTIQEEFKGNYIINIDDYLDISQIPSNYKKEIEDSETQDIVYIMHTSGSTGKP
                     KGVKVTVNNLNYITENVQRITPCDEDSTLLFMTPYTFDVSITEICGWVYNGGAVVCRDL
                     NSNTWFDDIREVLYKYNITHVAACPSVFLTMMNIYSNEINIFNNLKFVVLAGERFSLNI
                     HKVWKESNWSFRLFNAYGPTETTVYCTLYELSKESSYDEIPIGTPLQGVEYIIDENTSE
                     LLVSGQCITNGYLDYENTSKYFINVNDCLYYKTGDLVELNGGLLYFKGRNDKQIQL"
     CDS_motif       complement(5364..5417)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg40_5_0001"
                     /evalue="5.60E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg40_5"
                     /protein_end="111"
                     /protein_start="93"
                     /score="22.0"
                     /tool="antismash"
                     /translation="YIMHTSGSTGKPKGVKVT"
     CDS             complement(5735..5872)
                     /locus_tag="ctg40_6"
                     /transl_table=11
                     /translation="MPISNVILKLEESASHYPKKTAIYGINKNFTYEEVQRITSFFLII
                     "
     CDS             complement(5917..6465)
                     /locus_tag="ctg40_7"
                     /transl_table=11
                     /translation="MSKNFSKENNVGVLIWARSTPKENIFQEMISLVEQNYKKNIIFFV
                     DDLCPQQVYNRSKETQNFYNEKYRSYFKSKNVQFYFSSQLVSLEKIDNHYLQEMIDDMT
                     IKEYVTILPHKKHENGEFELNEVIHTIFQELLLKEALSMVSTILLGKFSQNLVIFHKKI
                     TGQNIETIIIERMSYNRRK"
     CDS             complement(6458..8068)
                     /locus_tag="ctg40_8"
                     /transl_table=11
                     /translation="MKNNDIIEFIRTKISREFNLEDELDGISIHIVGSLAIKIRLGRSL
                     ENYFNGESDIDCIVVVLENGIITQNSKIFERKVLDTFLNNQVDVINYSIVYGKKRNSIN
                     IKFIKKENLYKLTDIREVNFKSMRKDSLVRHKPVTKFYGEESEIEFEFEYLEKQAGELY
                     MIEYHFFTFSNNIFFLCDIHSMLLFSLNISNKNYKDLPEIFFLKMELYSILKKKDDLYY
                     FSMFKNFHHIVKSPKELSKLVPKLSIFLIDKDESIDLLTYFEIRKLTRDASLDPIIINC
                     GVREPHDFIRTDFLNFKIYTALEILENFSWIKTIQDSKIYLEANENDNLYSVIELFSLF
                     EEFSNKLNNIFASKKICSDKNMSRFEDYYDKKLFFQMDSKVSSNLNFLGGLEDCFYKLV
                     KLNDTELIKMSDEFFSEKTKKIENIIQKYNIIVKLVSFLCNEDASNTSKSLKNFFEELT
                     NTKAKMLKNIKKIPPSSDTASLIDVLFLSGDFKSKNELHRLFKQNSVKSLSGEILKQGC
                     IDFKGEVIKIGKRRYYKIE"
     CDS             complement(8055..9140)
                     /locus_tag="ctg40_9"
                     /transl_table=11
                     /translation="MNKHCSNECFFIDDDEISNCWSMVNILPAVVWKVGKVYLPGKPSG
                     CSIGKRPMNLYLKIMKDFGFEITENNGGFYLEKGNAGISEITLPFPSFTGTSIAIYLAM
                     LSNNEININNVSIEPEIIYLISVIKNLGYKIIFDKIARVIKFKGKTENNGVLSVRVPFD
                     RNVLVTRMVSDLVSYGKFEWLNEEQHYLEELLLFLKKCGFEIYSDDYRIKIVALDKVVD
                     QERVVLNCGYFPKICSDWQPLLVILLCHYLIPFELSDDVFENRFQIFSQLVYLNNNIVL
                     NKKSSNKIVIDYCDTTEKITTSSNLEFKLLNIRDAAAILIASHQSKLNIEFSNLLQLFR
                     GYETLENVLGEKVELYSYEKQ"
     CDS             complement(9150..9710)
                     /locus_tag="ctg40_10"
                     /transl_table=11
                     /translation="MEYTSAGVILINMNSKVLIVQYPEGHWGFPKGYKETEDKSLVDTA
                     KRELKEEIDISPNFFLDTNRYQFNESYGKKKIIYFIAFTINSNINLCNGLNSYKWVDIE
                     DLDKFPGFLSKQIVRKLVELKLDDITIVKKVNLKDNITKTNEKVDIPPSKHAYSRLVPL
                     ELINDNIKIENIPNTIDSYYLNI"
     CDS             complement(10504..11412)
                     /locus_tag="ctg40_11"
                     /transl_table=11
                     /translation="MKLFEDLQWRGLVKQYSSDSLIEKLNNGKLTFYIGTDPTADSLHL
                     GHYSSFLIAKRLAKYGHQPIILIGGATALVGDPRGTSERDLAEQEKIFDNFEKLKNQIQ
                     KIFPYEIVNNYDWTKNIMAIDFLREFGKHITAGYMSNKELVKRQFATGISFTEFSYMLL
                     QGMDFYHLFTTKGVTLQIAGSDQWGNMTTGIDLVRKKTGEEVFAMTMPLITDEEGKKFG
                     KSEGNAIWISENKNTPEELHNFLLNVSDDIVISLLKKLTFLSRKDIEEIESRHKNGTGY
                     AQGILADTVTFDIHGVSINKK"
     CDS             11666..12520
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR01716"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_12"
                     /sec_met_domain="TIGR01716 (E-value: 2.9e-61, bitscore:
                     196.5, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSKLGSTLRKVRNGKQISICSVADEHLSKSQISRFERGESEISC
                     IRLINILDKLHITLDEFLILHDEDYTKTESFANLVQYIRKQYSLQNINNIQSLLSDSSN
                     YTLDPFEKTMVKSILHTMDSSIIPSDDELLQLADYLFKVEKWGYYEIILLGNCVRTIDY
                     NSVFLLTKEMLNNYIYSSLNKTNKRIVTQLAINCLILSIDMEEFTNCFYLIDEIKALLD
                     NELNFYEQTVFLYATGYFEFKRWQSTSGIEKMKQAIQVLDILGEDNLKLHYTIHFDKLI
                     NNK"
ORIGIN
        1 tgtcttcatc acactgaaca tacataaaaa gaggacctat ccggtcctct ctagatgtta
       61 gcttttcgtc acccactaca gttgacaaag agcccataat agctactgtc ttagctcatt
      121 tttttactta aagccttgat agacttgaca aatggtagaa aagagccgat ttttctgtct
      181 aacttttggg gtgcagttta tattagctct gtgcttttat tttcttttga ggtaatttct
      241 tacttatttt cgcttagtaa tatatttcaa ctcatattat atcttttaaa tagtattcca
      301 aataccagcg ataatactgt aatagacgca ccaataataa aaagattaaa agtattatta
      361 ggatttaata ctaccgaaaa aaaaccagta ccaataggca taaaaagaat agctactgtg
      421 aatataatac caaacactct ccctaaaaat tcgttatcga catctctttg aacaatagag
      481 aaaaactgaa tattaaagat agaaagaaat aaactaaaaa gtgctggaga aatagctaaa
      541 ataattacat tatgaaacat aatataaaac ggagtagcta acattaacac tagtcctgat
      601 aaagatagaa acaacattaa tttcttactt gataactttt tattcacaaa actacttaat
      661 attgctccaa taaatccgcc gattgcttcc gctgttaaaa aggtgccata aagtccagtt
      721 gaaatttctc caaacatttg attactatag ggcaataata aattataagc agctagaaaa
      781 aaattaacaa gtgcagaaag tacgataata ataaagattg acttatgatt gtaaacatac
      841 ttaaatccaa tttttaaatc attaatgatt cctctgaatg tcattttctc ctttgtgacc
      901 actgcttcat taataggtac aataaagaaa attagtaaag cagctattag aaacgacaat
      961 ccatccaata gtaacacacc atgtatccca agtagcttat ataaaaaaat tgccaccata
     1021 ggaattgtta ctttaattac agtacttgtt gtctctagca atgaattaag ttgtgatata
     1081 ctatcctttt ttacaatttc tttcgtaaaa gctttataag atggtccaga aaaagtactc
     1141 atgaatgcca aaattacatt agttagtaca attgcataaa ccaaccattg atcttgtgat
     1201 atgaatgaaa gtactaagca agcaatacca cacaagatat ttgtagcaat aataattttt
     1261 ttcttttaaa actatccgca aatacaccac caaataaatt aaatagaaca cctatcacac
     1321 tttctagcga ctgatatact gcaactaatg atagtgaagt tggattaatc ccagcaagaa
     1381 atgtattgtt agcaaaatca aacatagtat ctcctatacg agacacccct ttactactaa
     1441 ctaagtataa aatattcttt ttcttaacgt ctttcaaaac gttcctccca tataaactgc
     1501 tcagatagtt cccgtagttt agacaatttt tgattatgtt gttcctcggt ctcacttaca
     1561 ataattgcaa taaaatctcc ttctactaca gaagttatac catctgactc ctctcctact
     1621 tttgaaaata catatatctc atcagtccat tcaaataatt ccatatcagg agccgaaact
     1681 agttttcctc gttttttata tggacaatat gtagcagaaa taaatttagg acgttctaaa
     1741 tcagtacttg gatgtagctc tttattatca aagacatttt cccaaaattc ttcaaaaatg
     1801 ttaacaccaa aacttctttg aattaaattt ggaatatcgc ctccaccaaa tctttttcct
     1861 acttcacaaa atacaaattc ccccttgttc tcatcaaaaa accattcaaa gtgaaaagga
     1921 ataattgagt agtcattaac aaattcttta agaactttgc tacattcact aaatattttt
     1981 cgtaaaaagg ggatattttt ttcatagaga ctattcgttc tgactgtgaa ttcatcacta
     2041 gttccaattg ttcccaataa taattcttca tattcatgtg agtaaaatct gattatatta
     2101 ctaccttgcg aataaccatc acaagtcagc attttttgta aatctacgta ctcttcaata
     2161 atatactgag aattaatgaa cttctccgga atttgttcac ctctagaata tttttttatc
     2221 ccaacacaag ctgctccaaa tcgaggttta attatagatt tatctcctgc tgtatttttc
     2281 caaaataatt cgatatcttt ttgcgtctca ataagacgaa acataggctg aggtactatc
     2341 tcaaacagta cagatctcat taaatattta tcctgaaaca atgaattaac taaatatgat
     2401 gaattttttt tcttgaagta atcgtttaga aaacccgcat gccacatata atgctcatca
     2461 agtgttaaaa cttcctctat actatccaca tcaatagatt ctctgataat tgaaatcatc
     2521 tttggtaatg tatagtcttc taaatatatt atttttggta atctattacc tttcataagg
     2581 tatttttcat attttttctg cgtatcaagc ggagcaatta caattgcatc ttgatctgct
     2641 aaataattta acttggctag tgttggagtg tatttgttta ataaaatttt cattctactc
     2701 tttcctcgtt tatgtatata atttgctatc taatattgca agatgcattt ctacttggcg
     2761 cctctaaaaa ttaatttttt taaattaaga aaattgattt tacaagattg ctagagttat
     2821 atctcattat attttggagt ttctaaatat cttctattag caataaattt ttttctttaa
     2881 agtttaacaa aagtctcaaa atctaaaaaa tccttatttg tatagataac taattgatta
     2941 tttactagat aaacagtaac atataaagta tcatcaatct gagttagctg atatagagac
     3001 tgttttacag atttagtata tctctccaaa tcatcttctt taattatacc taaaaaatct
     3061 atagaggtat ttgttgtatg ccttaaacta ttttttagaa gtttttgatc attattttta
     3121 ataggataat tgctaccata cacatatgca ggcctgaata ctttttctac ataatttgtt
     3181 tttatactat cctccacacg tttcttataa tctaaataat tttcgtcttt ataaacaaca
     3241 atataaatgc ttgtatgaaa atctccaagc gtgtacttat atttagtgcc taaatagtct
     3301 tttccattaa caaggcattt tataacaata ctatgttgat tgaaaagttt aagaagatat
     3361 tgaccgatat tatatgctaa aaataaattg atttgttgag tacttaatga tttcgcatca
     3421 gattctaaat caactttgta aacattcaaa ctactctcca tctttttaat ctcaaattct
     3481 gaatcttccc cgcatttaac taaatcctga taaaaagaac ttttcattat ttcatacata
     3541 ttattgtttt tatgaattag cttaatataa tcttcataag ttgattcaaa attgattttt
     3601 tttccattct ttaggttact aataatttcc aatattgtag ctggagttga ggcatcagca
     3661 attgaatggt ccataagacc gatcagagta tattgcttat cattttttaa taaaattaaa
     3721 gaatttagta aacctccttc ttttctactg tccatcaaaa tcattctgat atttttcttt
     3781 atatcgctaa tgtagtcgat agattgatat gaaacatcaa atattggcat actgtccaaa
     3841 ttttccattg ctttttctac aaaatataac ttgtcatctt caaaaacaaa actagttcgt
     3901 aacatagtta cgttagcaat taaatcattt attagaccta caactacttc aaacgcttct
     3961 cctttttgaa aaacatattc aaattcaata aaactttcaa agttatcata ataatatact
     4021 ctttgtaaat gtaatgtctc atacttactt acaatctgac cacttcgata aatataattc
     4081 tcaacatttt tcaattctgc agtcatagta ttgatgtcaa ttttaatgtt ctcattcttc
     4141 tttggttcat catctatatt tttattcttc tttaaagaat ctatatattt actcagttgc
     4201 attatcgtcg gataattata gatatcactc aaagtaattg aaatgttaaa tctttcttca
     4261 agtcccatca aaagtaaaac tgacgacaac gagtctccac ctaaattaaa aaaattagaa
     4321 tttttggtta ttttttcttt accaatagtt ataacatttt caaataaatc tttgatttct
     4381 agttctagtt catttaacat actatcagat tcttcggtat ctaaaaaatt atacattaac
     4441 ctatctttat cgactttttt actctgattt aaaggaaatt cagacactaa atgaaaatta
     4501 ttaggtatca gatgtttctc aaaattttga ctaaaataat ttttaaaata ttcttcatca
     4561 aaatattttg tcttgataaa tgctataatt ttgttatttt tataaataac ttttgattga
     4621 tctacatatt caatttcttc aattctattt tcaatctcac ctaattctac tctcattcca
     4681 tttaattgta tttgcttatc attcctacct ttaaaatata ataatccacc atttaattca
     4741 actaagtctc ctgtcttata gtataggcaa tcatttacat ttataaaata tttacttgtg
     4801 ttttcataat ctaaatagcc attagttata cactgaccac tgaccaataa ttccgaagta
     4861 ttctcatcta taatatattc aacaccttgc aaaggtgtcc caattggaat ttcatcatag
     4921 ctgctttctt ttgataattc atataaagta caataaacgg ttgtctcagt gggaccatac
     4981 gcattgaata atcgaaacga ccaattactt tctttccaaa ccttatggat atttaaacta
     5041 aatcgttcac ccgcaagtac cacaaatttc aaattgttaa atatatttat ttcatttgag
     5101 tatatattca tcatagttaa aaatacagaa gggcatgcgg caacatgcgt aatattatat
     5161 ttgtatagta cttctcttat atcatcaaac caagtatttg aatttaaatc cctacaaact
     5221 actgcgccac cattataaac ccacccacat atttcagtaa ttgaaacatc aaaagtatac
     5281 ggagtcataa atagtagagt cgaatcttca tcacaaggag ttattctttg aacattttct
     5341 gtaatgtaat tcaagttatt taccgttacc ttaaccccct taggttttcc agtactccct
     5401 gaggtatgca ttatataaac aatatcctga gtttcactat cttctatttc ttttttataa
     5461 ttggaaggga tttggctaat atcaagataa tcatctatat taataatgta attcccttta
     5521 aattcttctt gtatagtaga aaaattgtaa ttatctgtaa tcagataatt tatattcaaa
     5581 tcgtcaatac tatctttaat tctattaaaa ttagtctttg tactaaacgg aacataggta
     5641 ttgttggact ttagtattga aaaaaatgaa ataataatat tttcattatg ttccaaaatt
     5701 aatcctatat ttttattttt tccaactatt tttcctagat aattagaaaa aaacttgtga
     5761 tacgttgtac ttcctcgtat gtaaagtttt tatttattcc ataaatggca gtttttttag
     5821 gatagtgcga cgcactctcc tctaacttta aaattacatt actgataggc atagttttct
     5881 cctcaatgca ctttaaatta ataaatttca aataatttac tttcttctat tataactcat
     5941 tctttcaatg ataatagttt caatattttg ccccgtgatt tttttatgga aaatcactag
     6001 attctgacta aactttccta acaaaatcgt tgagaccata gaaagtgctt ccttaagtaa
     6061 taattcttga aaaattgtat ggataacttc atttagctca aattcaccat tttcatgctt
     6121 tttatgcgga agaattgtga catattcttt tattgtcata tcatcaatca tttcttgtaa
     6181 atagtgatta tcaatttttt ctaaactaac taactgacta ctaaaataaa attgcacatt
     6241 ctttgacttg aaataacttc tatatttttc attataaaaa ttttgagttt ccttacttct
     6301 attgtagact tgctgaggac ataaatcgtc aacaaagaat ataatatttt tcttataatt
     6361 ttgctcaaca agacttatca tttcttgaaa aatattctcc ttgggagtac ttctagccca
     6421 tattaaaaca cctacattgt tttccttact aaagttttta ctcaatttta tagtatctcc
     6481 ttttacctat tttaattact tctcctttaa aatctataca accttgtttt agtatttcac
     6541 cagataatga ctttactgag ttttgcttaa aaagccgatg aagttcattt tttgacttaa
     6601 aatcaccaga taaaaacagt acatcaatta agctagcagt atcactagag gggggtattt
     6661 tttttatgtt ttttaacatt tttgcttttg tattcgttaa ttcttcaaaa aaattcttta
     6721 aactttttga ggtattggaa gcatcttcat tacataaaaa tgatactaac ttcacaataa
     6781 tattatattt ttgaataata ttctcaattt ttttagtttt ttcagaaaaa aactcatcac
     6841 tcattttaat taattctgta tcgttaagtt tgaccaattt gtagaagcaa tcttccaaac
     6901 cgcctaaaaa gtttaaatta gaagatactt tgctatccat ttgaaaaaat aatttcttat
     6961 cataataatc ttcgaatcta ctcatatttt tatcgctaca aatttttttt gatgcaaaaa
     7021 tattatttag tttattcgaa aattcttcaa ataaactaaa taattcaatt acagagtaca
     7081 gattatcatt ttcattagct tctaaataga tttttgaatc ttgtatggtt tttatccatg
     7141 aaaaattctc taaaatttcg agagcagtat aaatcttaaa atttaaaaaa tcagttctta
     7201 taaaatcgtg tggctctctt actccgcaat taataatgat ggggtctaga gatgcatctc
     7261 tagttaattt tctaatttcg aaatatgtga gtaaatctat tgattcatct ttatcaatta
     7321 aaaaaatact taacttcgga accaactttg aaagctcttt aggagatttt actatatgat
     7381 gaaaattttt aaacatcgaa aaataatata gatcatcttt tttctttaag atggaatata
     7441 attccatctt aaggaagaat atttccggaa gatctttata atttttatta cttatattta
     7501 agctaaataa taacattgag tgtatatcac acaagaagaa aatattattt gaaaatgtaa
     7561 aaaaatgata ttcaatcata tataattctc cagcctgctt ttctaaatac tcaaactcaa
     7621 actcaatctc actttcttct ccataaaatt tggtaactgg tttatgtctt actaaagaat
     7681 cttttctcat acttttaaag tttacttctc taatgtcagt aagcttgtat aaattttctt
     7741 ttttgataaa tttgatattg atactgtttc tttttttacc atatacaata gaatagttaa
     7801 tcacatctac ttgattattt aagaaagtgt ctagcacttt tctttcaaaa attttgctat
     7861 tttgtgttat tattccattt tcaagaacta ccacaataca gtctatatca ctttcaccat
     7921 taaagtaatt ttctagactc cgccctaatc ttattttaat tgctaatgat ccgacaatgt
     7981 gaatacttat accatctagt tcatcttcca aattgaattc tctagaaatt tttgttctta
     8041 taaattctat aatatcattg tttttcatag ctatataatt ctactttttc acctaataca
     8101 ttctcaagag tctcataacc tctaaaaagc tgcaacaaat tactaaattc tatatttaat
     8161 ttactttgat gacttgcgat taaaattgcg gcagcatctc tgatatttaa taatttaaac
     8221 tctaaattag agctggttgt aattttttct gtggtatcgc aataatcaat tacaatctta
     8281 tttgaagatt tcttatttaa aacaatatta ttatttaaat acactagttg tgaaaaaatt
     8341 tgaaatctat tttcaaaaac atcatctgaa agttcgaacg gaatcaaata atgacataat
     8401 aaaataacaa gtaatggttg ccaatctgag caaattttag ggaaatagcc acaatttaaa
     8461 accacacgct cttggtctac tactttatct agtgctacaa tttttatccg ataatcatct
     8521 gaataaattt caaagccaca ttttttcaaa aatagtaaca attcctccaa atagtgttgc
     8581 tcctcgttaa gccattcaaa ttttccataa cttactagat ctgataccat tctagtaact
     8641 aaaacatttc tatcaaatgg cactctgaca gataaaactc cattattttc agtctttcct
     8701 ttaaatttga taactcttgc aattttatca aatataattt tgtagccaag attttttata
     8761 acagaaatta aatatattat ctctggttca attgaaacat tgttaatatt tatttcatta
     8821 tttgataaca ttgccaagta aattgctata gatgttcctg taaatgaagg aaatggtaaa
     8881 gtaatttcac ttattcctgc attacctttt tccaaataaa atcctccatt attttcagta
     8941 atttcaaacc caaaatcttt cataattttc aaataaagat tcattggccg tttcccaata
     9001 ctgcaaccac taggttttcc gggtaaataa acttttccta ccttccaaac tacagctggt
     9061 aagatattaa ccattgacca gcaattcgaa atctcatcat catcaataaa aaaacactca
     9121 tttgaacaat gcttgttcac tctatttagt taaatattca aataatatga atctattgta
     9181 ttaggaatgt tttctatttt gatattatca ttaatcaatt ctaaagggac taacctagag
     9241 taagcatgtt ttgacggtgg tatatccact ttttcattag ttttagtaat attatctttc
     9301 aaatttactt tcttaacaat agtaatatca tccaatttta gttctaccaa ttttctgact
     9361 atttgtttag ataaaaagcc aggaaattta tccaaatctt caatatcaac ccatttatat
     9421 gagtttaagc cgttacatag attaatatta ctattaatag taaaagctat aaaatatata
     9481 attttctttt tcccataact ttcattaaat tgatacctat tagtatccaa aaagaaattt
     9541 ggtgatatgt caatttcttc tttcaattct ctttttgctg tatcgacaag tgacttatct
     9601 tcggtctctt tatacccctt tggaaacccc caatgtccct ctggatactg tactatcagt
     9661 acttttgaat tcatattaat taaaattact ccagcagatg tatactccat atgttaactt
     9721 atccttatac tagtatttag tgcagttagc tactgccaaa gcctaagcga ttaacttaga
     9781 ataagcgact gtagataggt tattttattc aaatcatgta ttttttgggg gattccctta
     9841 tcacaatttt tatcgcaatt gattatctat ttggtaacat acttatgttt catctcacgt
     9901 tagatgattc aacaaaaatt gcatagagta gcaagttcga ttgaacacta tacgaactag
     9961 aaaaagtcgg tcacactcgc ttagattttt taaactaata tatgcttgaa ttcttacaca
    10021 gcagtctaaa atatctcaat caagaagttc ttatcactct aaaagactct gactctggac
    10081 atcgtaactt tttctccttc atttctctcg tagccaggac tataagcttt atactaaacc
    10141 aacaacatca attgttagta tcacataaaa aactcttctc accccaaaaa atgtgaacaa
    10201 tacaattatg ttaataaaca ggatagttaa aatttcttaa cagacatatc tcttaaaaag
    10261 aagtaagcga gttggaaaga ataacacaca aggtaatctg cataattgat ttacttagtt
    10321 caataaacct atcaaattta ctaaattttt gaaaataaac agatgatcta actcatgtga
    10381 ccgatagaat gttatcttta aaatcggcca catttcatga tcatttgtcg tgcatccaag
    10441 aatatgactt ggagcaagaa actatgaatt tttattacag tttatctacc tccatctaag
    10501 agtttatttt ttatttatac ttactccatg aatgtcaaat gttacagtat ctgctaaaat
    10561 gccctgtgca tagccagttc cgtttttatg tctactctca atttcttcaa tgtcttttct
    10621 agacaaaaaa gttaattttt ttaataaaga aataacaata tcgtctgaaa catttagtag
    10681 aaaattatga agttcttctg gcgtattctt attttcagaa atccaaatag catttccttc
    10741 agactttcca aattttttcc cctcttcatc tgttattagt ggcatagtca tagcaaacac
    10801 ttcttctcca gttttttttc ttaccaaatc aattccagtt gtcatatttc cccattgatc
    10861 tgatccagct atttgaagtg tcactccctt agtagtaaaa agatggtaaa aatccattcc
    10921 ttgtaaaagc atatatgaaa attcagtaaa tgatattcct gtcgcaaatt gtctctttac
    10981 tagttcttta ttagacatat aacctgccgt tatgtgttta ccgaattccc ttaagaaatc
    11041 aatcgccatt atattttttg tccaatcata gttattcaca atctcgtatg ggaatatttt
    11101 ttgaatttga ttttttaatt tttcaaaatt atcaaatatt ttctcttgct ctgctaaatc
    11161 tctttctgag gttccgcgcg gatcccctac caatgcagta gcccccccaa ttaaaatgat
    11221 aggttgatgt ccatatttag ctagtcgttt tgcaattaag aacgatgaat agtgccctaa
    11281 atgtaagctg tctgcagttg gatctgttcc tatgtaaaaa gttaattttc cattatttag
    11341 cttttcaatt agactatcac tagaatattg tttaacaagc cctctccatt gtaagtcttc
    11401 aaataatttc atttgtttat acctctttct taaaaaatct gtactataat caaacagtta
    11461 taatattaag tctttagagt cttctaaaga cttaggtgta cacctaagta aattacccac
    11521 caacaataat gataatatcc atcactaaaa tcaaaatcgg caaaattttt gaaactttct
    11581 ccatatttag acttcctttc aatttctatt tattgtacaa taattaaaac taagttaact
    11641 tttttgttgg ggaaatggga aaattatgaa atcaaaactt ggtagcacac ttagaaaagt
    11701 tcgtaacggc aaacaaataa gtatatgctc tgttgctgat gagcatcttt caaaatcgca
    11761 aatatcccga tttgaacgtg gagagtcaga gatatcatgt atccgactga tcaatattct
    11821 agacaaatta cacattactt tggatgagtt tcttatttta cacgatgaag actatacaaa
    11881 aactgagtca tttgccaact tagtacagta tatccgtaaa caatattcat tacaaaacat
    11941 caataatata caatctctac tttcggattc ctcaaattac actttagatc cttttgaaaa
    12001 aacaatggta aaatccattt tacacacaat ggattcaagc atcattccat cagatgatga
    12061 attacttcaa ctagcagatt atctctttaa agttgaaaaa tggggatact atgagatcat
    12121 tttattaggt aactgtgtac gaaccattga ctacaactcc gtctttctat taacgaaaga
    12181 aatgttaaac aattatatct actcttcatt gaataaaact aataagcgaa ttgtcactca
    12241 gcttgctatc aattgtttaa tccttagcat agatatggaa gaatttacta attgcttcta
    12301 tttaatcgat gagataaaag cattgttaga taacgaatta aacttttatg aacagacagt
    12361 ttttctctat gcaactggtt actttgaatt taaacgttgg caatcaacta gtggaattga
    12421 aaaaatgaaa caggctatac aagtacttga tattttagga gaggataatt taaaattaca
    12481 ctatactatt cattttgata aactgataaa caacaaataa agtaattatc tactatttaa
    12541 ttttcctcct tttctggcct gatcacttaa gctataaatg gaagatttga acctgcttag
    12601 aaactagctt gaagccatag taaaaagtct tggtagtcaa ggctttttac tatggttc
//
