LOCUS gnlProkkaPLMPKKEI_19 25277 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|PLMPKKEI_19. ACCESSION gnlProkkaPLMPKKEI_19 VERSION gnlProkkaPLMPKKEI_19 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 07:57:44 Original ID :: gnl|Prokka|PLMPKKEI_19 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25277 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25277 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1449:5277]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1450..5277 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25277 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25277 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" aSDomain 94..921 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_1_Epimerization.1" /evalue="7.70E-139" /label="ctg19_1_Epimerization.1" /locus_tag="ctg19_1" /protein_end="276" /protein_start="0" /score="455.6" /tool="antismash" /translation="MMLHAAKGFDPERVEKTLQALIEHHDALRMVFREENGHIVQAYQS ISESEVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLQNGPLLKAEQYRTEAGDHLLI AVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQ QAEYWSQIAAEQVSPLPKDCKTEQRIVKDTSSVLCELTEEDTKHLLTDVHQPYGTEIND ILLSALGLTMKEWTEGAKIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDI" aSModule 94..1380 /domains="nrpspksdomains_ctg19_1_Epimerization.1" /domains="nrpspksdomains_ctg19_1_TIGR01720.1" /incomplete /locus_tags="ctg19_1" /tool="antismash" /type="unknown" CDS 94..1413 /NRPS_PKS="Domain: Epimerization (0-276). E-value: 7.7e-139. Score: 455.6. Matches aSDomain: nrpspksdomains_ctg19_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (280-429). E-value: 8.3e-55. Score: 176.7. Matches aSDomain: nrpspksdomains_ctg19_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 128.8; E-value: 5.2e-39)" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_1" /sec_met_domain="Condensation (E-value: 1.9e-75, bitscore: 244.3, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MMLHAAKGFDPERVEKTLQALIEHHDALRMVFREENGHIVQAYQS ISESEVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLQNGPLLKAEQYRTEAGDHLLI AVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDWAEELAAFSQSAHLLQ QAEYWSQIAAEQVSPLPKDCKTEQRIVKDTSSVLCELTEEDTKHLLTDVHQPYGTEIND ILLSALGLTMKEWTEGAKIGINLEGHGREDIIPNVNISRTVGWFTAQYPVVLDISDADA SAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNYLGQFDSEVKTDFFEP SAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKEFERATIEERMERFKENLLM LIRHCTEKEDKEFTPSDFSADDLEMDEMGDIFDMLEENLK" CDS_motif 118..192 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_1_0001" /evalue="2.70E-07" /label="C2_LCL_024-062" /locus_tag="ctg19_1" /protein_end="33" /protein_start="8" /score="23.0" /tool="antismash" /translation="FDPERVEKTLQALIEHHDALRMVFR" CDS_motif 397..462 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_1_0002" /evalue="2.70E-12" /label="NRPS-E2" /locus_tag="ctg19_1" /protein_end="123" /protein_start="101" /score="38.7" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 865..915 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_1_0003" /evalue="1.00E-08" /label="NRPS-E5" /locus_tag="ctg19_1" /protein_end="274" /protein_start="257" /score="27.1" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 934..1380 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_1_TIGR01720.1" /evalue="8.30E-55" /label="ctg19_1_TIGR01720.1" /locus_tag="ctg19_1" /protein_end="429" /protein_start="280" /score="176.7" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKEFERA TIEERMERFKENLLMLIRHCTEKEDKEFTPSDFSADDLEMDEMGD" CDS_motif 955..1014 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_1_0004" /evalue="6.30E-12" /label="NRPS-E6" /locus_tag="ctg19_1" /protein_end="307" /protein_start="287" /score="37.5" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 1048..1077 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_1_0005" /evalue="1.10E-03" /label="NRPS-E7" /locus_tag="ctg19_1" /protein_end="328" /protein_start="318" /score="11.3" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1450..1545 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg19_2_NRPS-COM_Nterm.1" /locus_tag="ctg19_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1450..5277 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg19_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 5.8e-119. Score: 388.5. Matches aSDomain: nrpspksdomains_ctg19_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 2.7e-110. Score: 360.6. Matches aSDomain: nrpspksdomains_ctg19_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.5e-25. Score: 81.1. Matches aSDomain: nrpspksdomains_ctg19_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1060-1267). E-value: 3.4e-37. Score: 120.9. Matches aSDomain: nrpspksdomains_ctg19_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 333.8; E-value: 3.3e-101)" /gene_kind="biosynthetic" /locus_tag="ctg19_2" /sec_met_domain="Condensation (E-value: 2.2e-94, bitscore: 306.6, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 8.6e-122, bitscore: 397.3, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 8.9e-19, bitscore: 58.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQ KDGYEPKELLFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKQLQEQSLQSEPHQYVPLYDIQ SQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKLAYNENVFDEEFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QAHETKPLTDWFKEAVNVNPDAPALTYFGQTLSYRELDEEANRLARRLQKHGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLAHQEMKEQAA ELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANIQGL VKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLINCY GPTEGTVFATAHVVHDIPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCISGMG VSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVANRHESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYVKNGGPDGLQ DVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLYAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPE WLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAEILLEFLNTQTVTVS" aSDomain 1477..2373 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="5.80E-119" /label="ctg19_2_Condensation_DCL.1" /locus_tag="ctg19_2" /protein_end="308" /protein_start="9" /score="388.5" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEDFEGQTTFAEQRKKQKDGYEPKEL LFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1477..5250 /complete /domains="nrpspksdomains_ctg19_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg19_2_AMP-binding.1" /domains="nrpspksdomains_ctg19_2_PCP.1" /domains="nrpspksdomains_ctg19_2_Thioesterase.1" /final_module /locus_tags="ctg19_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1486..1527 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg19_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1549..1665 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0002" /evalue="2.50E-12" /label="C2_DCL_024-062" /locus_tag="ctg19_2" /protein_end="72" /protein_start="33" /score="39.1" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIH" CDS_motif 1882..1947 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg19_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 1993..2031 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg19_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2269..2364 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg19_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2413..2526 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0006" /evalue="1.00E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg19_2" /protein_end="359" /protein_start="321" /score="56.6" /tool="antismash" /translation="QEQSLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYP" aSDomain 2857..4050 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_2_AMP-binding.1" /evalue="2.70E-110" /label="ctg19_2_AMP-binding.1" /locus_tag="ctg19_2" /protein_end="867" /protein_start="469" /score="360.6" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNVNPDAPALTYFGQTLSYRELDEEANRLARRLQKHGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLAHQEMKE QAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKGNITTHANI QGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLI NCYGPTEGTVFATAHVVHDIPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCIS GMGVSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYAGRIDDQVKIR" CDS_motif 3043..3084 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg19_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3277..3336 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0008" /evalue="9.20E-08" /label="NRPS-A_a3" /locus_tag="ctg19_2" /protein_end="629" /protein_start="609" /score="24.4" /tool="antismash" /translation="AYIMYTSGTTGKPKGNITTH" CDS_motif 3844..3933 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0009" /evalue="5.50E-13" /label="NRPS-A_a6" /locus_tag="ctg19_2" /protein_end="828" /protein_start="798" /score="41.1" /tool="antismash" /translation="PFGAIGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 4015..4080 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0010" /evalue="9.60E-12" /label="NRPS-A_a8" /locus_tag="ctg19_2" /protein_end="877" /protein_start="855" /score="36.8" /tool="antismash" /translation="YAGRIDDQVKIRGHRIELEEIE" aSDomain 4369..4575 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_2_PCP.1" /evalue="1.50E-25" /label="ctg19_2_PCP.1" /locus_tag="ctg19_2" /protein_end="1042" /protein_start="973" /score="81.1" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYVKNG" aSDomain 4630..5250 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_2_Thioesterase.1" /evalue="3.40E-37" /label="ctg19_2_Thioesterase.1" /locus_tag="ctg19_2" /protein_end="1267" /protein_start="1060" /score="120.9" /tool="antismash" /translation="IFAFPPVLGYGLMYQNLSSRLPSYKLYAFDFIEEEDRLDRYADLI QKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKQGVSDLDGRTVES DVEALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDM PEWLASWEEATTGAYRMKRGFGTHAEMLQGETLDRNAEILLEFL" CDS_motif 4774..4848 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg19_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5306..6034 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 4.5e-55. Score: 179.4. Matches aSDomain: nrpspksdomains_ctg19_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 211.9; E-value: 1.2e-64)" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_3" /sec_met_domain="Abhydrolase_6 (E-value: 1e-15, bitscore: 49.6, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 2.1e-07, bitscore: 21.5, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGI FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELFDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5348..5998 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_3_Thioesterase.1" /evalue="4.50E-55" /label="ctg19_3_Thioesterase.1" /locus_tag="ctg19_3" /protein_end="231" /protein_start="14" /score="179.4" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELFDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5531..5602 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg19_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg19_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6136..7362 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 340.8; E-value: 1.4e-103)" /gene_kind="transport" /locus_tag="ctg19_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISRWFDTHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIHILYF GVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVM LSILFFIRLLSLICLLIPILGIHQSDLWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHQSI" CDS complement(7377..7934) /locus_tag="ctg19_5" /transl_table=11 /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFAA VNFINGWPRIVYGSDALNLFMNSTLIIVMTVLFTLLFLLLLYVKFSRAYKKNERMKSKR TYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEVEMN RFKEIILKNTETKKLKFKKDKH" CDS complement(7988..8926) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 156.6; E-value: 1.5e-47)" /gene_kind="transport" /locus_tag="ctg19_6" /transl_table=11 /translation="MVKHQQASAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRFT IAFAAATVPILFGWVKLSIRIKDVIAILPLALLYPALFFSFQAFGLVYSSSSEAGIIQA AIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSA LSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPFREPG FVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGVVILNESLAWYH LAGAVCIMIGVVGSNINLEKKTKRPGMPAKK" CDS 9176..10384 /NRPS_PKS="Domain: Aminotran_1_2 (54-396). E-value: 7.6e-22. Score: 69.7. Matches aSDomain: nrpspksdomains_ctg19_7_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 248.4; E-value: 2e-75)" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_7" /sec_met_domain="Aminotran_1_2 (E-value: 3.2e-22, bitscore: 69.8, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MIRALQELEKRHLIYSVPKSGYYIVKKTGKSKSGQPGPIDFATSA PDPDVFPYLDFQHCINKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLANQQVFADERHIF ITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLETLWIPAIGVKRTEEGLDIAE VERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENK KADPLYAYDLSSHVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQ AALEIYLKSGMYGRHKEKIRNSYKERSLKLHQAIQTHRQLGRGRFTFSSGQAPCMHTHL VLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLM SHL" aSDomain 9338..10363 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_7_Aminotran_1_2.1" /evalue="7.60E-22" /label="ctg19_7_Aminotran_1_2.1" /locus_tag="ctg19_7" /protein_end="396" /protein_start="54" /score="69.7" /tool="antismash" /translation="DFQHCINKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLANQQVFAD ERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLETLWIPAIGVKRTEEG LDIAEVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGD LEENKKADPLYAYDLSSHVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDC SMISQAALEIYLKSGMYGRHKEKIRNSYKERSLKLHQAIQTHRQLGRGRFTFSSGQAPC MHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERG VK" CDS complement(10379..11053) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg19_8_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 192.8; E-value: 8.2e-59)" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_8" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSLCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEE LL" aSDomain complement(10556..10744) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg19_8_ACPS.1" /evalue="6.00E-20" /label="ctg19_8_ACPS.1" /locus_tag="ctg19_8" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11158..11466) /locus_tag="ctg19_9" /transl_table=11 /translation="MVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMEL TILFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12114..12857) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 222.1; E-value: 1.3e-67)" /gene_kind="transport" /locus_tag="ctg19_10" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVME GPIQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(12871..13326) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 172.7; E-value: 1.5e-52)" /gene_kind="transport" /locus_tag="ctg19_11" /transl_table=11 /translation="MFIIFYLFPAFNVTLDPFPSAVIAFSLNVGAYASEIIRASILSVP KGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLSNTFISLIKDTSLASQILVAELFRK AQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQHVIERRLDRYVAK" CDS complement(13292..13528) /locus_tag="ctg19_12" /transl_table=11 /translation="MGSGAAVILADTFRGNLLYDSPYDSFLYIRNDPGADYGACQNVES ETFEMGVQRIRIRNTRHSSSRSIVHHFLSVPGL" CDS complement(13562..14368) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 233.4; E-value: 3.9e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_13" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVIANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATDAGAKVEGVEGLAQSLQLIQQGRVDMTYNDKLAILNYLKTSGNKNVKIAFETGD PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14484..15356) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 246.3; E-value: 6.3e-75)" /gene_kind="regulatory" /locus_tag="ctg19_14" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMEDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15482..16060 /gene_functions="biosynthetic-additional (rule-based-clusters) Flavoprotein" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_15" /sec_met_domain="Flavoprotein (E-value: 9.1e-34, bitscore: 106.9, seeds: 143, tool: rule-based-clusters)" /transl_table=11 /translation="MKLVVGMTGATGAIFGVRLLQWLKAAGVETHLVVSPWANVTIKHE TGYTLQEVEQLASYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSLASIRTGMADNLLTR AADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMPAFYNQPSSLEEMVDH IVFRTLDQFGIRLPEAKRWNGIEKQKGGA" CDS 16057..17484 /locus_tag="ctg19_16" /transl_table=11 /translation="MIMAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGPAARAASNLG DKSPALLFNNIYGYHNARIEMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQNV GIYRMQVKGKDRLGIQPVPKHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPLLY DQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTGHYS GGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPNEIVA VNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFNLPQVM WALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHYSQPLDS PLTTKEWEQKLMDLMNK" CDS 17725..18189 /locus_tag="ctg19_17" /transl_table=11 /translation="MIRVNSMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMIS AGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAE YERDRFSCRIVSVKEDVAKYADLTSGVRIQLHRPEEVLGRWEKTLEDLKR" CDS 18332..19099 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036:alpha/beta hydrolase fold protein (Score: 55.2; E-value: 1.4e-16)" /gene_kind="biosynthetic-additional" /locus_tag="ctg19_18" /sec_met_domain="PF00561 (E-value: 1.3e-15, bitscore: 48.4, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 2.9e-10, bitscore: 31.8, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MIGSAIYYPRLFSSDIKQKYQWVFIDHRGFAKPKRELRAEDSRLD AVLADIERMRTFLQLEDVIILGHSGHAFMALEYARTYPKQVRKVALFNTAPDNSEERQR KSESFFMETASLERKKRFEKDIANLPQDIDKDPERRFVHMCIRAEAKSFYQERPHAAAL WDGVFTNMPIIDELWGNTFAQIDLIQRLADVRMPVYIGLGRYDYLVAPVSLWDAVDGLY PHMDKVIFERSGHQPMLEEPEAFDQSFSKWLDQ" CDS complement(19140..20618) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 53.2; E-value: 2.9e-16)" /gene_kind="transport" /locus_tag="ctg19_19" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVMISVQTGVLTINRFIDLVSILGILIPVIYFIIMFTSKKAD KTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIKLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPMIKRAMKGVL" CDS 20898..22652 /locus_tag="ctg19_20" /transl_table=11 /translation="MAEFILNAADFGVPGDGKTDSTERINQCLSTAVSKGYHTVWFPKG IYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLNNCLIQVV DGVNVSGGSMIIKDNLLRKFSRGIWIAQGNAVIEGNILNPDAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYINGSAGSIVSGNTINNLSAGTATAIQTNTSTNSKIIGNRIFKGTINKHSSD AIDGNIIV" CDS complement(22667..22888) /locus_tag="ctg19_21" /transl_table=11 /translation="MKILGVTGVILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTTF AECVVILFFVLVLVKEMYVIYKSKKKNP" CDS 23014..24648 /locus_tag="ctg19_22" /transl_table=11 /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYIAGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSIQEP STQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQGICDE KVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAGYVAATTF HQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRMPRVVGSAVSIVGAL VIGQAAVQAGIVSQAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASAVMGFYGLI LGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPESISKEDKVRQ GKDQRPEPAASRGMVNKDLEEGDQNGT" ORIGIN 1 caaggcccgg tggagggcga agtcatcctg acgccgatcc agcgctggtt ctttgaaaag 61 aacttcacga acaagcacca ctggaaccaa tcggtgatgc ttcacgccgc gaagggcttt 121 gaccctgaac gggtggagaa aacattgcag gcgctgatcg agcatcatga cgcgctccgt 181 atggtctttc gtgaggaaaa cgggcacatc gttcaggcgt atcaatcgat cagtgagagc 241 gaggtcagct tcgaaatcgt ggatctgtac ggctccgatg aagagatgct gagaagccag 301 attaaaattc tcgcgaacaa gctgcagagc agtctcgatc tgcaaaacgg gccgcttcta 361 aaggcggagc aatatcgcac agaagctggg gatcatctgc tcattgctgt acaccatctc 421 gtggtcgatg gtgtgtcatg gcggattttg cttgaagatt ttgcttcagg ctacatgcag 481 gctgagaaag aagagagcct tgtcttcccg caaaaaacaa actccttcaa ggactgggcg 541 gaagaactgg cggcattcag ccaatcagcg catcttttac agcaggctga atactggtcg 601 caaattgccg ctgaacaggt ttctccttta ccaaaggatt gtaaaacaga gcagcggatc 661 gtcaaggata catcatctgt cctatgtgaa ttaacggaag aagacacgaa acatctttta 721 acagatgttc atcagccata tggaaccgaa atcaacgata ttcttctcag cgcgcttggt 781 ttgacaatga aagaatggac agagggggcc aaaatcggca ttaaccttga gggacacggc 841 cgggaggaca tcattccgaa tgtgaatatc tccaggacgg tcggctggtt tacggcacaa 901 taccctgttg tgctcgacat atctgacgca gatgcctcgg ctgtgatcaa aacagtcaaa 961 gaaaacctgc gccgcattcc ggacaaaggt gttggctacg gcattcttcg ttatttcaca 1021 gaaacagcgg aaacaaaggg cttcacaccg gagatcagct tcaactattt gggccaattc 1081 gacagtgaag tcaaaaccga tttctttgaa ccgtcagctt tcgatatggg gcgccaagta 1141 agcggagaat cagaggcgct gtacgcttta agcttcagcg gcatgatcag aaacggccgt 1201 tttgtgcttt cctgctccta caatgaaaag gagtttgaaa gagccacgat tgaagagcga 1261 atggaacggt ttaaagaaaa cctcctgatg ctaatccgtc attgcacgga aaaagaagac 1321 aaggaattca caccaagcga ctttagcgcc gacgaccttg aaatggacga gatgggagat 1381 atctttgaca tgcttgagga gaatttaaaa taaaacgcaa gggaattaca gaaggcggga 1441 gcgaaacata tgagtcaatt tagcaaggat caggttcaag atatgtatta cctatcgccg 1501 atgcaggaag ggatgctttt tcatgccatc ctgaatcccg gccaaagctt ttaccttgaa 1561 caaatcacga tgaaagtaaa aggcagcttg aatatcaaat gtcttgaaga aagcatgaat 1621 gtgatcatgg accggtacga tgtatttcgt accgtgttca ttcacgaaaa agtaaaaaga 1681 cctgtccaag tcgtattgaa aaaacggcag ttccatatag aagaaatcga tctgacacac 1741 ttaacgggca gcgagcaaac agccaaaatc aatgagtaca aagaacagga taagatcagg 1801 ggttttgatt tgacgcggga tattccgatg cgggcagcca ttttcaagaa agctgaagaa 1861 agctttgaat gggtgtggag ctaccaccac attattttgg acggatggtg cttcggcatc 1921 gtcgtacagg atctatttaa ggtatacaat gctctgcgcg aacaaaagcc gtacagcctg 1981 ccgcccgtca aaccgtataa agactacatc aagtggcttg aaaagcagga taaacaagca 2041 tcactgcgtt actggcgcga gtatttagag gactttgaag gacaaacgac gtttgcggag 2101 caaagaaaga aacaaaagga cggctatgag ccgaaagagc tgctcttttc actgccggag 2161 gcggaaacaa aggcctttac cgagcttgca aaatcgcagc ataccacttt aagtacggcg 2221 ctgcaggcag tctggagcgt attgatcagc cgctatcagc agtctggcga tttggccttc 2281 ggtacagttg tttcagggcg tcccgcggaa atcaaaggcg ttgaacatat ggtcgggctg 2341 tttatcaacg ttgtcccgag acgtgtgaag ctgtctgagg gtatcacatt taacggcttg 2401 ctcaagcagc tgcaggagca atcgctgcag tctgagccgc atcaatatgt gccgctttat 2461 gacatccaaa gccaggccga tcagccgaaa ctgattgacc acatcattgt ttttgagaac 2521 tatccgcttc aggatgcgaa aaatgaagaa agcagtgaaa acggctttga tatggtggat 2581 gttcatgttt ttgagaagtc gaattatgat ctcaacctga tggcttcccc gggagatgag 2641 atgctgatta agcttgctta taacgagaat gtgtttgatg aggagtttat cttgcgcttg 2701 aaatctcagc ttctcacagc aattcagcag ctcatccaga atccggatca gcctgtcagc 2761 acgatcaacc tcgttgacga cagggagaga gaatttttgc taaccggctt aaacccgccg 2821 gctcaagctc atgaaacaaa gcctctgacg gattggttca aggaagcagt gaacgtcaat 2881 ccggatgcac ctgcgcttac gtatttcggc cagaccctgt cttatcgcga attagatgag 2941 gaagcgaacc gccttgcacg ccggctgcaa aaacacggtg cgggcaaagg ctctgttgta 3001 gcgctgtaca cgaagcgctc acttgaattg gtgatcggca ttctcggtgt attaaaggcg 3061 ggagcagcct atctgccggt tgatccgaag ctgccagagg accgaatctc gtatatgctg 3121 gctgacagtg cggcagcctg tcttctggcg catcaggaga tgaaagaaca agcggctgag 3181 ctgccgtata caggcacaac gctcttcatt gatgatcaaa cacggtttga agaacaggca 3241 agcgatcctg caaccgcgat tgatcctaat gatccggcat atatcatgta cacgtccggc 3301 acaaccggaa agccaaaggg caatatcacc actcatgcca atattcaagg attggtcaag 3361 catgtagact acatggcatt ttctgatcag gatacgttct tgtctgtttc gaattacgcc 3421 tttgacgcat ttacctttga tttctatgct tctatgctga atgcggcacg gctcattatc 3481 gcagatgaac atacgctgct tgatacagaa cggctcacag atctgatcct gcaagagaat 3541 gtcaatgtca tgtttgcgac aaccgcacta tttaatcttc tcacagatgc gggagaggat 3601 tggatgaagg gactacgctg tatattattc ggcggagagc gcgcctcagt gcctcatgtc 3661 agaaaagcgc tgcgggtcat ggggccgggc aagctgatta actgctacgg gccgactgag 3721 ggaacagtgt ttgcgactgc tcacgtcgtg catgatatac cagattccat ctcctcattg 3781 ccgattggaa agccgatcag caatgccagt gtttatattc tgaatgagca aagccagctc 3841 cagccattcg gggcgatcgg tgaactgtgc atcagcggaa tgggcgtgtc aaaagggtat 3901 gtaaatcgtg ctgacctcac gaaggaaaag tttatcaaga acccgttcaa gccgggagaa 3961 acgctttacc gcacagggga tttagcgcgc tggctgccgg atggaacgat tgaatacgcc 4021 ggccgtattg acgaccaggt caaaatacgc ggacaccgga ttgagcttga agaaatcgaa 4081 aagcagctgc aggaataccc aggtgtgaaa gatgcggtcg ttgtggcgaa ccgccatgag 4141 tctggcgatg catcaatcaa tgcctatctc gtgaaccgga cgcagctttc agctgaggac 4201 gtgaaggcgc acctgaaaaa acagcttcct gcttacatgg tgccgcaaac ctttaccttc 4261 ttggatgagc ttcctttaac gacgaacggg aaagtcaata aacggctgct cccaaaacct 4321 gatcaggatc agctggcgga agaatggatt ggaccgcgga acgagatgga agaaacaatc 4381 gcacaaatat ggtctgaggt tctcggcaga aagcaaattg gcattcatga cgatttcttt 4441 gcgctcggag ggcattcctt gaaggcaatg accgccgctt cccgcatcaa gaaagagctc 4501 gggattgatc ttccagtaaa gcttttgttt gaagcgccga cgatcgccgg catttcagcg 4561 tatgtgaaga acgggggccc tgatggcttg caggatgtaa cgataatgaa tcaggatcag 4621 gagcagatca ttttcgcatt cccgccggtc ttgggctatg gccttatgta ccaaaatctg 4681 tccagccgct tgccgtcata caagctgtac gcctttgatt ttattgagga ggaagaccgg 4741 cttgaccgct atgcggattt gatccagaag ctgcagccgg aagggccttt aacattgttt 4801 ggatattcag cgggatgcag cctggcgttt gaagctgcga aaaagcttga ggaacaaggc 4861 cgtattgttc agcggatcat catggtcgat tcctataaaa aacaaggtgt cagtgatctg 4921 gacggacgca cggttgaaag tgatgtcgaa gcgttgatga atgtcaatcg ggacaatgaa 4981 gcgctcaaca gcgaagccgt caaacaaggc ctcaagcaaa aaacacatgc cttttactca 5041 tactacgtca atctgatcag cacaggccag gtgaaagcag atattgatct gttgacttcc 5101 ggcgctgatt ttgacatgcc ggaatggctt gcatcatggg aagaagctac aacaggtgct 5161 taccgtatga aaagaggctt cggaacacac gcagaaatgc tgcagggcga aacgctagat 5221 aggaatgcgg agattttgct cgaatttctt aatacacaaa ccgtaacggt ttcataaaag 5281 aagtgatgaa aggaggagac agccaatgag ccaactcttc aaatcatttg atgcgtcaga 5341 aaaaacacag ctcatctgtt ttccgtttgc cggcggctat tcggcgtcgt ttcgccctct 5401 ccatgctttt ttgcaggggg agtgcgagat gctcgctgcc gagccgccgg gacacggcac 5461 gaatcaaacg tcagccattg aggatctcga agagctgacg gatttgtaca agcaagaact 5521 gaaccttcgc cctgatcggc cgtttgtgct gttcggacac agtatgggcg gaatgatcac 5581 cttcaggctg gcgcaaaagc ttgagcgtga aggcatcttt ccgcaggcgg ttatcatttc 5641 tgcaatccag ccgcctcata ttcagcggaa gaaagtgtcc cacctgcctg atgatcagtt 5701 tctcgatcat attatccaat taggcggaat gcccgcagag cttgttgaaa ataaggaggt 5761 catgtccttt ttcctgcctt ctttccgatc agattaccgg gctcttgaac aatttgagct 5821 tttcgatctg gcccagatcc agtcgcctgt tcatgtcttt aacgggcttg atgataaaaa 5881 atgcatacga gatgcggaag gctggaagaa atgggcaaaa gacatcacat tccatcaatt 5941 tgacggcggg cacatgttcc tgctgtcaca aacggaagaa gtcgcagaac ggatttttgc 6001 gatcttgaat cagcatccga tcattcaacc gtgatcaaaa gcggacagct tcggctgttc 6061 cgcttttttt tgtgttgaat gccaattttt gcatggtata atagtcgaaa tactcaaata 6121 aaggaaggtc gaaacatgcg cacgtctccc aggatgaaat ggtttgtatt gctgtttacg 6181 tttgttttcg ccatcggaat gaactcattc agaaattcct ttcaattttt tatgctgcca 6241 atggcagatg ccttccatgc cgacaggtcg ctgatctcgg tttctgtcag catttttatg 6301 atcacaaccg gcatcgtcca gttttttgtc ggttttttta tcgaccgttt cagtgtcaga 6361 aaaattatgg cgcttggagc tgtctgcatc agcgcaagct ttttggtgct tccttattca 6421 ccgaatgttc atgtgttttc cgccatttac ggtgtgcttg gcggaatcgg gtattcctgc 6481 gcggtcggcg tgacgaccca atatttcatc agccgttggt ttgacacaca caaaggtctg 6541 gcgcttgcta ttttgaccaa tgccaactct gcgggcctgc tgcttctctc acccatttgg 6601 gctgcagctc cgtatcatgc cggctggcag agtacctata ccattttggg aatcgtcatg 6661 gcggctgttc tgctgccgct cctcgtcttt gggatgaagc acccgccgca tgcgcaagcg 6721 gaaactgtga aaaaatctta tgattggcgg gggttttgga acgtgatgaa gcaatcccgc 6781 ctcattcata tcctgtactt cggcgtgttt acttgcggat ttacaatggg aattattgat 6841 gctcacctcg tcccgatact taaggatgcg catgtctctc atgtcaacgg aatgatggcc 6901 gcgttcgggg cgtttatcat cattggcgga ttattggcag gctggctgtc tgatctcctc 6961 gggagcagaa gcgtcatgct atccatctta tttttcattc ggctgctcag cctcatttgc 7021 ctgctcattc ccattctcgg aattcatcaa agcgaccttt ggtacttcgg gtttatcctg 7081 ttattcgggc tcagttacac aggcgtgatc ccgctgaccg cggcgtcaat ttcggaaagc 7141 tatcaaacag gattgatcgg atcgctgtta ggcatcaatt tctttatcca tcaggttgcc 7201 ggagctctta gtgtgtatgc gggcggtttg ttttttgaca tgactcatgg ttatttgctg 7261 attgtcgctg tgtgcatcgt gtttgtgggt ttatcggctg taatagagct ggtgccgttt 7321 ttagataaac aaaaggcaaa agaaacccac caatcaatat aaaaggatca gcactgtcaa 7381 tgcttatcct ttttaaattt gagttttttt gtttcggtat ttttaaggat aatctccttg 7441 aatctgttca tctccacttc ggaatgaaaa aaatgttttg ggatcgcaat atattggcca 7501 cttgatgtat tgaccctgaa gatattttta tattcgaaaa cagctgtgat ttcatcccaa 7561 ttgaaaatga ggtcatattt tttagaacat atacgaattc cttcttggtt cagagtatat 7621 gttcttttcg atttcatccg ttcgttcttc ttgtatgctc tggaaaactt cacatataga 7681 agcaggagga acagcagtgt aaacagaacg gtcatcacga taatcaacgt actgttcata 7741 aacaagttaa gcgcgtcact gccataaacg atacggggcc atccgttaat gaagttaact 7801 gcagcaaata tggcgcaaaa caatagaaag taaaagcatg atatttttgc gatttgataa 7861 aaaaagattt ctcttacatc cttaaaagtg atttctcctg gaagattgat actttcacta 7921 gcatattgaa tcatacggta aacctacacc tctaaccatg tttttccttt cagtctagca 7981 taatttttca tttttttgca ggcataccag ggcgctttgt ttttttctcc agattgatat 8041 tgctccccac cacgccaatc ataatacaaa cagccccggc aagatgatac caggccaggc 8101 tttcgttgag aatcacaact cctgcaatca tcgtcacaat ggtagataca tgattaaaag 8161 cgctcatttt aaacgcctca attcgcgaca gcgtatagtt agacagaaat gaagtgacaa 8221 gtgaagacag cacgcccaaa tacacaatgg cgagaacgaa gccgggctcc cggaacggca 8281 gaaaataagt gccgactgtt cccgccgctc cgtgacgcac aagggcgatg gcgttgaaga 8341 cgacaaagcc gatggctgac atgatatagg tgagctcggt cagcttgaac cgctgcgtca 8401 tttttctggc agcagtattg tacatcgctg aagacaaagc ggacaatagg atcagcaaag 8461 acccttttaa gctggctgat tccacgtcaa cgcctttcat cacaaaaata aacatgacgc 8521 cggcaacgga taaaaccgtg aacccctttt gcgtccacgt tgggcgttcc tttaaaacat 8581 aagcggcaaa gaccatcgtg aaaatcggaa tggctgcctg aataattccc gcttcagagg 8641 aggacgagta cacaaggccg aatgcctgaa agctgaaaaa taacgcggga tacagcaggg 8701 cgagcggcaa aatggcaatg acgtccttta tgcggattga tagctttacc cagccgaata 8761 agatcggtac agtggccgca gcaaacgcaa tggtgaaccg atgcgccaaa atatcaaacg 8821 gctctgctgt ttgcagtgcg atttttacga atagaaagga taaaccgata atgaacgaat 8881 ataaaatagc cgctatataa gcggaggctt gctgatgttt aaccataatg ggaagggctc 8941 ctttacctga attgcagcgc cggtcgctcc ctttattgta tggccgcggt cagaacggta 9001 caatgagaaa aacaatgaac tgtaccggta aaaaacaggg ggagaaggca tggagaaata 9061 tatgagtcta gtaacgagga tagaggagat gatgcaaagc acctcctatc aagaaggaga 9121 caggcttcca tctatccgtc agatgtccgc ccgctaccaa gtcagcaaaa gcacagtgat 9181 ccgcgcgctg caggagctgg aaaagcgcca ccttatctat tctgttccga aaagcggcta 9241 ttatattgtg aaaaagacag ggaaatcaaa aagcgggcag cctggcccca tcgactttgc 9301 cacatctgcg ccggatcccg atgtgtttcc gtatcttgat tttcagcact gcatcaacaa 9361 agcgattgat acatacaaaa acgatttgtt tatttatggg acgccaaagg ggcttccctc 9421 actcatccgc gtactccgaa agctcttggc caatcaacag gtatttgcgg atgaacggca 9481 tattttcatt acatcaggtg tccagcaggc gttatctctg ctttgtgcca tgccgttccc 9541 aaatgggaaa gaaaagatcg ccattgaaca gccgggctac catttgatgg tcgaacagct 9601 tgagacgctt tggattcccg ccatcggggt gaaacgaacg gaagaagggc ttgatatagc 9661 cgaggttgag cggttatttc aaacagaatc gattaaattt ttttatacga tgccgcgctt 9721 ccataacccg cttggctgct cattgtcaga gcgtgataaa caggagcttg tgagactggc 9781 agaagcgtat gatgtctatc tcgttgagga tgattacctc ggtgatctgg aagaaaataa 9841 aaaggcagat ccgctgtacg catatgatct gtcctcacat gtcatctatt tgaaaagctt 9901 ctcaaaaatg atgttccccg gccttcgcgt gggggcggct gttttgcccg aagcgctgac 9961 tgacacgttc tatgcgtaca aaaaactgaa cgacatcgac tgttcgatga tttctcaagc 10021 ggcattggag atttacctga aaagcggtat gtacggcagg cataaggaga aaatcagaaa 10081 ttcttataaa gagcggtcgc tgaagctaca tcaagccatt caaacacaca ggcagctggg 10141 aagaggccgc tttacgttct ccagcgggca ggcaccctgc atgcacaccc acctggtgct 10201 tcctcaggat ctgcccgcct caagagtgat tcatagactg aaaaaacaag gggttctcct 10261 tgaggcgata gaccgtcatt atttatcaga ttatccgaaa gaaaatctat taaaaatcaa 10321 tatttccaat gtgaaaacgg aagatattga gcgcggtgtc aagctgttga tgagccattt 10381 ataaaagctc ttcgtacgag accattgtga tatcctcggg gaaatcaggg tgtgcggcgc 10441 atacagccat tttgtagccg ggatcgacct catacgtttt gatatagcat agggaatggc 10501 tgtccggaag ctcaatggat acttgtccgt cctggtgcag gcgcactgaa aaggaatcaa 10561 gcggaagcga taagcctttg ccttcctgtt tgataaagct ttctttcatt gaccatagat 10621 gataaaaata gtctgtctgc tcgtccttgt cttttgctaa aaggtcgctg tactctgttt 10681 ttgaaaagaa gcgcttggcg atctcaagac tgatcggttt cgttttttcg atatctatgc 10741 cgatcggctg tgaatcaaac gcgcaaatga cccagcggcc ggagtgagaa atgttgaaat 10801 gagcgtcggg aagatcaggg atgcacggct tcccgtattc ctgcgtgcta aagcggatat 10861 cggatttgtc caactgatac tgcctgctta tgactgagcg aacgagcaca tctcccagca 10921 gggtgcggtg agcatcttct ttatgataaa atctccggca tttctcccgt ttttcaggtg 10981 atatgaaaga catgaaccgt tcattttctt cctgtgaaag cgggcggtcc atataaattc 11041 cgtaaatctt cattctagat cctccgtctg caaaagattg tcaaaaccat cctatcatac 11101 ttccacaaga ctcatataga ggagaaaata aaaaaacaaa gccaaggcgg ctttgtttta 11161 gtgtacaggc ggagatgctt tcacagcggc tgtccgcctt gccacagcat aattcagcaa 11221 ctggattgac tggggcaatg aaaagcgcaa aataagtccg gtgaggatgg cggtcaaaat 11281 ggtgccaaaa ccgatcggtc cgcccatgcc ccatgccgca aacaaaatgg ttaattccat 11341 gccgttccgc acccattgca cattccagcc ggttttttct gtaatcagca tcatcagtga 11401 atcacgcggc cccgcgccaa ggcctgctga tacataaaca ccgacgccgt aaccgatcag 11461 caccacgcct agagagaaga cgatgatcga gcctgtgtag gtcgaggggg caggcagaat 11521 gaaattgaaa aaatctataa atacaccaat gagcaccata ttcaggaggg ccccaatttt 11581 cggccaagct ctcgtaaaca atgacgtgaa tccgacgatg agcgctccaa taatgatgga 11641 ccactggccg acggtaagcc cgaagtgctg aaacaggctg taatgaaatg catcccacgg 11701 actaatgccg agtgcttttc cttctatcgt cagggataca ccaaaagcca aaatgatcaa 11761 accggcaaaa taaaatgtcc agcgcagaac aagttcttgc ttcacgtgag gtcccttctt 11821 tcgtaaaaat cagtcgattg tcattgtagc acatctgaca gaagggcgga ataggcgaaa 11881 ggggctcaac aaaaaaacag ggccgccgcg ggcgccctgt ttcagcgtgt tggcaaaccc 11941 ttgcattcgt tgtcaggcct gtgcttcggt gctcacgaat ttaacattcg ctgtgctcca 12001 atgctcgccc ttcctagact tcaaaggttt tcaatcacgc tgaaaatgac aaaatcctaa 12061 aacgaaaatc gttttaggat ctgtaacagg gcgcaggcgc cctgtttttc ttattacagc 12121 gggttcaaaa tccggttcaa gaaccgctgt gtccgttctt cttttggtgc ggagaaaatt 12181 tgctccggcg gtccttgttc cacgataacg ccgccgtcga tgaagatgac ttcatccgca 12241 acttcctgcg cgaacttgat ttcgtgggtc acgacgacca tggtccagcc ttcattggcc 12301 aagtccttga taaccttcag cacctctccg acaagctcgg gatcaagcgc tgaggtcggt 12361 tcgtcaaaca gcatgagttc aggctgaatc gccagtgcgc gggcgatgcc gacgcgctgc 12421 tgctgtccgc cggaaagctg gaatggatat aaatccattt tgtccttcaa tccgacttta 12481 tctagaagct gaatcgcttc ttttctgact tcctctttgt tccgtttttg cacctgaata 12541 gggccctcca tcacgttttc aagagctgtg cggtgcggga acaggtgata cgcctgaaac 12601 accattccgg attttcggcg aagctttagg atatccgcct gtttcacctt tttggagaaa 12661 tcgatggaga aatcatcaaa tgcaagttct ccgcgattcg ggatctccag agcgttcagg 12721 cagcggagca gcgtcgtttt ccctgaacct gaaggcccaa gtatggcgat gacttttcct 12781 ttttcaatct tcatatctat cttttttaaa atttcatttt caccgaatga tttgtttaat 12841 cctttaacgg taagcatact cggaacctcc ttatttggcc acgtagcggt caagacgccg 12901 ttcgatgaca tgctggacga gtgagagcag gaagcagata atccaataaa taaaggctgc 12961 ttcaatatag atcactaaaa tttgatcaag attccgcgcg ccgatttcct gggcttttct 13021 gaacagctca gcgaccagaa tttgagaggc gagggatgta tctttaatca ggctgataaa 13081 ggtattggat aatggcggga tcgacacacg aaacgcctgc ggcaaaatga cgcggaacag 13141 cgttttttga tgtgtcatgc caattgtgta gccggcttcc cattgccctt tcggcacgga 13201 taaaatagat gcccgaatga tttcagatgc ataggcgccg acgtttaatg aaaaggcgat 13261 aactgcgctt ggaaatggat ctaatgtgac gttaaaggcc gggaacagat agaaaatgat 13321 gaacaattga acgagaagag gagtgccgcg tattgcggat acgtatacgc tgaacaccca 13381 tctcaaaggt ctcactttcg acattctggc aagcgccgta atcagcgcca ggatcattcc 13441 gaatataaag gaaagaatcg taaggggaat cgtatagtag attccccctg aaagtatcgg 13501 ccagaatgac tgctgcacca gatcccacgg gatcgccgtg ccaagcgtca atgccggcag 13561 attatttaga aacatcttcg ccgaaccatt ttttagaaat tttagaaaga gtcccgtcct 13621 ctttcatttc ttttaatgct ttgttgactt gatcaacaac ctcgccgctt cctttgcgga 13681 acgtgaaata tgttgattgc ggatcgcctg tttcaaacgc gattttcacg tttttgttgc 13741 ctgatgtttt taagtagttc aatatggcaa gtttatcgtt gtatgtcata tcgacgcggc 13801 cttgctggat caattgaagg gattgtgcca agccttcaac gccttcaact ttcgcgcccg 13861 catctgtagc taatttgttg tagttgcttg tcagtgattg agctgatgtt tttcctttta 13921 catctgcttc tgacttaata tcgttgttgt cttttttcgt aacgacaacg gctcttgatg 13981 ttgtgtattt atctgagaaa tcatatttgt cttcacgatc tgtttttccg acttggttgg 14041 caatgacgtc aaaccgtttg gaattcaggc cggcaaacat gctgtcccat tgtgtttcct 14101 taaagtcgac tttaagcccg aggcgttttg cgacttctgt gataacttcg acatcatagc 14161 cagtcagttt atcagtgtct ttgtcgtggt aagtgaacgg ctcatatgtt ccttccgttc 14221 cgactgtgag cacacctttt ttcttaattg aagcccaaag atcgccatct ttggcattat 14281 cttttgactg attgtcattt cctgctccgc aagctgcaag agctgcaata cttacgacca 14341 tgaataaagc caataatgct tttttcatct tattccccac ttttctggtt gattttattg 14401 aaataaaaaa atagcttaca aatctaaagg ataacttttt tttagtatga gtcaagtaat 14461 tggttttcat aaggcaaaat cttttaaaat aaatccaaaa attgctgtgc cggtttaggc 14521 aaataactgt ccgttctcca catgacagcc ggtgtcataa tgaagggatt attttcgata 14581 tggacggtgt gaacgtgatt tctcatatga acgggaatca ttgtgacagg caaaatagac 14641 gcgccgaatc cggatgacac gaggctgagc aaagttgcag agtcgtggca ttcacaaaca 14701 atgcgcggct ccaggttcaa acgatgaaat tcattcatga cctgattata gacgcctttt 14761 ccgttgacag gccgcagcag gatcagcgga aatgaaggaa tatcctccat cttaatggtg 14821 tctccgcacg gatatccggc ttcatctgaa agcacgagca cacatggaat gtcatcaagc 14881 tgcttgaatt gtactgtgtc acttttgatc agtgttgtcg tgaccgccgc atcgatttgc 14941 cggctttcca gcagctctaa cagtgtcgcg ggctcatttt cccaaatatt aaaggtgaga 15001 tgggggtatc tctctttgat ctgtgttact ttttcaagca tcagagccgc gcaataaatc 15061 gttgatccca cggcaagtgt accggctact tcctccttca gctcctgtac ctcaatgact 15121 gcatcttcaa acctatgcag aatctctttt gctcttttta gaaaaacagc tccttcatat 15181 gtaagagtca tttgtttttt cttgttacgg tcaaacagaa caacaccaag ctcgtcctcc 15241 agctgtttga gctgcctgct taaaggcggc tgcgccatgt gaagcttttt ggctgcggac 15301 gtaattttct gttcttgggc aatggtaatg aagtatcgaa gctggcgaat atccaaaaga 15361 aagcgccacc ttatcatacc ttttaggtat taaatataga tttaatagat atttttcata 15421 tggatatatc aggagtatga ttgaaatgaa agcagaattc aagcgtaaag gagggggcaa 15481 agtgaaactc gttgtcggca tgacaggggc aacaggggcc attttcgggg tcaggctgct 15541 gcagtggctg aaggccgccg gagtggaaac ccatctcgtt gtgtctcctt gggcaaacgt 15601 cacgatcaaa cacgaaacag gctatacctt acaagaagta gaacaactgg cctcatacac 15661 ttactcacat aaggatcagg cggcagccat ttcaagcggg tcgtttgata ccgatggaat 15721 gatcgttgcg ccgtgcagca tgaagtctct cgcaagcatt cgcaccggaa tggcggataa 15781 tctgctgaca cgtgcggcgg atgtcatgct caaggagaga aaaaaactcg tcctcttaac 15841 gagagagacg cctttgaacc aaattcatct cgaaaatatg ctagcgctta cgaaaatggg 15901 cacaatcatt cttcctccga tgccggcatt ttataatcag ccgagcagct tagaggaaat 15961 ggttgaccat attgtattca gaacgttgga ccaattcggc attcggcttc ctgaagcgaa 16021 gcgctggaat gggattgaaa aacaaaaagg aggagcttga tcatggccta tcaagatttc 16081 agagaatttc tcgcagccct tgaaaaagaa ggacagctgc ttacagtgaa tgaagaggta 16141 aagccggaac cggatttagg gcccgccgca cgggcagcca gcaatcttgg cgataaaagc 16201 cccgcgctct tatttaacaa catttatggc tatcataacg cgcgaattga gatgaatgtc 16261 atcggctctt ggccaaacca tgcaatgatg ctgggcatgc cgaaagacac accggttaaa 16321 gaacagtttt ttgaatttgc gaagcgttat gaccagtttc cgatgccagt gaaacgtgag 16381 gaaacagcgc cgtttcatga aaatgaaatc acagaagaca tcaatttgtt cgatatactg 16441 cctcttttca gaattaacca aggagacggc ggttactatt tagacaaagc atgtgtcatt 16501 tcccgcgatc ttgaagaccc tgacaacttc ggcaaacaaa acgtcggcat ttacagaatg 16561 caggtcaaag gaaaagaccg cctcggcatt cagcctgtcc cgaagcacga tattgcaatc 16621 catctgcgcc aagctgaaga acgcggcatc aatcttccgg tgactatagc gctcggctgt 16681 gagccggtca ttacaacggc ggcatcgact ccgcttctct atgatcaatc agaatacgaa 16741 atggcaggtg cgattcaagg cgaaccatat cgcattgtca aatcaaagct gtctgatctt 16801 gatgttccgt ggggcgctga agtggtgctt gaaggtgaga ttattgctgg agagcgtgaa 16861 tatgaagggc cgttcggtga attcacaggc cattattccg gcggacgcag catgccgatt 16921 atcaaaatta aacgcgtcta tcacagaaac aatccgatct ttgaacattt atacttaggc 16981 atgccttgga cagaatgcga ttacatgatc ggcattaaca catgcgtgcc gctttatcag 17041 cagttaaaag aagcgtaccc gaacgaaatt gtggcagtga acgccatgta cacacacggt 17101 ttaatcgcga ttgtttccac aaaaacccgc tatggcgggt ttgcgaaagc ggtcggcatg 17161 cgcgcactca caacgccgca cggactcggc tactgcaaaa tggtcattgt cgttgatgag 17221 gatgtcgatc cattcaacct tccgcaggtc atgtgggcgc tttcgaccaa aatgcatccg 17281 aaacacgatg cggtcatcat tccggactta tctgtcctgc cgcttgatcc gggatccaat 17341 ccatcaggaa tcactcacaa aatgattctt gacgccacta caccggttgc gccggaaaca 17401 agaggccatt attcacagcc gcttgattcg ccgctaacaa cgaaagaatg ggaacaaaaa 17461 ctaatggact taatgaataa ataaggaaag gatgttcgaa atgcatacat gtcctcgatg 17521 cgactcaaaa aagggagaag tcatgagcaa atcgcctgta gaaggcgcat gggaagttta 17581 tcagtgccaa acatgctttt ttacatggag atcctgtgaa ccggaaagca ttacaaatcc 17641 cgaaaaatac aatccagcgt ttaaaattga tccaaaggaa acagaaacag caattgaagt 17701 tccggcggtg ccggaacgaa aggcttgatc cgcgtgaaca gtatgtcaga ccgtctcttt 17761 gagctgcttg acgggagctg cctgaatgag aagcagcatg aggccttcgt tctgcaaaca 17821 gtatcagagg atggctggcc gcatgccgct atgatcagtg caggtgaaat tatcgcgctg 17881 agccgaactg atatccgaat cgctctgtgg aaaaacacaa tgacttctgc caacatcctt 17941 cgcacaggaa aagcacagtt cacggcatgg tggaagggag cagcctatta tgtaaagctt 18001 gaatgcgcgc ctttaccgcc tttgaaagat gccgaatatg aaagagaccg tttttcctgc 18061 cgcattgttt cagtgaagga ggacgttgcg aaatacgctg atttgacttc aggtgtccgt 18121 atacagcttc acagacctga agaggtgctg ggcagatggg aaaagaccct ggaagattta 18181 aaacggtaat atcgatagcc tgacgccatg cgtcaggctt tttttatata atgaaaacaa 18241 agggggcgtg agaaatggaa cgtgcgggga tctgtcactc ggacggcttt gatttagtta 18301 tcgaattgag ggcaagggcg cacccatcct tgtgatcggg agtgcgattt actatccgcg 18361 ccttttttcc tcagatatca aacagaaata tcaatgggtc tttatcgacc ataggggatt 18421 tgctaagcct aagcgggagc tacgtgcgga ggattcgagg cttgatgccg tcttggctga 18481 tatcgaaagg atgagaacat ttcttcagct tgaggatgtt atcatcctgg gacattccgg 18541 gcacgctttt atggctttag agtatgccag gacatatccc aaacaagttc ggaaggtggc 18601 gctcttcaat actgcgcctg ataacagtga agaaagacag cgaaaaagcg aatcattttt 18661 catggaaaca gccagccttg agagaaagaa acgctttgaa aaagacatcg ccaatttgcc 18721 gcaggacatc gacaaagatc ctgaaaggcg ctttgtgcac atgtgtattc gcgctgaagc 18781 aaaaagcttt tatcaagagc ggccgcatgc agctgcctta tgggatggcg tattcacgaa 18841 tatgccgatc attgatgaat tatggggcaa tacatttgcc cagattgatc ttattcagcg 18901 gttagctgat gttcgtatgc cggtgtatat cggattaggg agatatgatt atttggttgc 18961 gcccgtttcg ctatgggatg ctgttgacgg tttatatccc catatggata aggttatttt 19021 tgaaaggagc ggccatcagc cgatgctgga agaaccggaa gcctttgatc aaagcttcag 19081 caaatggctg gatcaataaa aaaacagccc gcagatcaaa atccgcgggc tgtttctgat 19141 tataagaccc ctttcatcgc gcgtttgatc atcggcgaga gcagcaggag aatgccgcca 19201 agaacgatag aaatcaaacc gatggtgccg aagtacattg tttcaggaat tttatcaaac 19261 aatccggcta cttgggcatt gatcgcttgg gctgctgcgt tcgtcagaaa ccacatactc 19321 attgtctgtg cagagaaggc agctggtgcc agtttcgttg tcacggataa accgactgga 19381 gacaggcaca gctctccaag cacgacaagc aggaagctga gaacaagcca aagcgggctt 19441 acgagtgctt cttttccttg catagcaggg aataccataa tgataaatga caatccggct 19501 aaaataattc caattgagaa tttaactggt gtagacggct ggcgtttgcc aagcttcatc 19561 cagagccatg cgaatattgg cgcaaaaatg acgacaaaca atggatttaa tgattggaac 19621 caagatgact gaagttcgaa tccgcccaat gaaagtttta tgcgttcatc agcgtatacc 19681 gcaagaatgg tcgctccctg ttcctgaatg gcccagaaca tgacagcacc gataaacaaa 19741 ggaacgtaag cggcaagacg ggatttttct gttttgtccg cttttttgct tgtaaacatg 19801 atgatgaaat aaatgacagg aatcaaaata ccgagaatac ttacaaggtc gataaaacga 19861 ttgatcgtca gcacgcctgt ttgtacagag atcatcactg caatcgccac gatgataaca 19921 ccgattccgg tgccaatcgc agatttttta gacagcggat tcggcacatt ggaacctgca 19981 agcccgaggt ttttctttct tgtcaaagca aatacgataa gtccgagaag cattccgacc 20041 gcggcagctc cgaagccgag atgatagttg tacttctgtc cgagtgttcc gacaattaac 20101 ggcgcaagta aaccaccgag gttaatcccc atgtagaaaa tactgaaacc tgagtcgcgg 20161 cgcgggtctt ctttcgtgta aagatcccca accacgcttg aaacgtttgg ttttaataag 20221 cctgttccga caatgataag caccatgctg atatagaatg ctatcgaact gcccggatag 20281 gcgagtgcaa tgtggccgaa cataatgaat atgccgccgt aaaaaacggt gtttgcggta 20341 ccgaataccc ggtcagcgag ccatccgcca ataatggtgg acatgtatac gagtgatccg 20401 taaatcgaca taatggcaac cgcagtgccc ttgtcaaagc cgagccctcc gtttaccgtc 20461 tctgtataca aatagtaaag taagattgct ctcattccat agtaagagaa acgctcccaa 20521 aattcggtga aaaatagtgt aaatagtcct cgcgggtgac caaagaaccc tttttgcggg 20581 acgcttttaa tgatactttc gttatcaatc gaagccatgt cagccaaacc ctttctaaaa 20641 aaagtgtatt ataaaaatca tattcttata taatgcttgt gtcaatataa tttatactca 20701 tttcaaatag ttccatattg gaaaaattat aaatacctaa aaatagtgat tttctcctaa 20761 tttttatact ctttatcgtg agattttctt acacaactat tcctttatat ttttttaata 20821 aaattttaga gaaatgtaca agcagatcgg gcctttgtga gtaacatgat agtaatcata 20881 gagaaggagg ctcgcaattg gctgaattca tattaaatgc agcggatttc ggtgttcctg 20941 gagatggtaa aacggattcg acagaacgga ttaatcagtg cctcagtaca gctgtttcga 21001 aaggctatca tactgtctgg tttccaaagg gaatatattt aatagacgca acgcttggcg 21061 gagatcttaa tcagaggttt cgaaacgcgg ggatcattgt tcccggcaac cttgagatta 21121 tgatggaccc cgaatgtatc atgaaagtga taccgaatag ttcgtggggt tattccgcat 21181 tttatgtggg caagcaagag aatataacca tttccggggg acaaattatc ggcgaacggg 21241 atgagcatac gtatgcctcg gcagggataa ggtcaaccca tgaatggggc tttggcatat 21301 gtattgaagg atgctcgaat gttgtcattg atgatgtgaa aatttctgat tttaccggcg 21361 atgggatcat agtcagccca aggggattaa agaccaatca agattatcga acgtcagagc 21421 aaattatcat ccgccgctgt gaagttcggc ggtcaaggag aaataacatt tccattaccg 21481 gatgtgacat ggtcacggtg gaggaatgct tgattgaaga tgccggaacg gggaatggaa 21541 cagcgccgaa attcggaatt gacattgaag gatatggcga aggtgacgtt gattatgagg 21601 aaccgattaa tgtatcaatt cgcaataacc actttgttgg aaacgtttca agttctgtga 21661 ccaattttaa cgggtatggc attttaatag aaggaaatca ctctgacaat acaatcagct 21721 acggatatgg gacgcaaaca gtgatcaagg gaaatatact gaggcgccct gaagacgcgg 21781 cggctgcgcc aagagtcggg ataaccggac tcggtgtatc acaaggaaaa gagaccagtg 21841 atgcagtgat cgctggcaac ctcattaccg gattttcaac tggaattgat gtcaggggaa 21901 agagcgttct tgtgacgaac aacaaaatca gcaactttga aaacacaggg atattggttt 21961 atcagtcttc cgacgtaaag gtagacggaa accaaattca aaacggactg tctgaaacaa 22021 ggcgcagcat tggtcttcgc gcagtgctgt cagatgacat cgcttttctg aataactgtc 22081 tcattcaagt cgttgacggt gtgaacgttt ccggcggaag tatgatcatt aaagataatc 22141 tcctgagaaa attcagccgg ggcatttgga ttgctcaagg gaacgcggtg attgaaggga 22201 atatactgaa tcctgacgcg tttgaagcag tgccggaatc atattctgtt tccgtcacaa 22261 acaatgccgg cgccatcatc aaaaacaata catttaaaga gttcaaaaat taccccattt 22321 attgctccac aagtgcgaaa acctcaatta tcggcaacca cttagagaga tctccgcttt 22381 tggtcaccat ctatatcagc gccggtgtgc atgagatttt tgataatacc atttcagtca 22441 acagaacagc cgggaatccg attgtgattt atatcaatgg ctctgcaggc tctatcgtct 22501 caggaaacac catcaataac ctctccgcgg gcactgcgac agctattcaa acaaacacgt 22561 caaccaactc caaaatcatc ggcaaccgca tttttaaagg gacaatcaac aaacacagca 22621 gtgatgcaat agacggcaat attatcgtct gaaaaaagcg ccccctctag gggttctttt 22681 ttttcgattt atagatcacg tacatttctt tcacaagtac taacacaaaa aataaaatta 22741 caacgcattc cgcaaatgtt gtcatcttaa agctggacat attgttataa acggcttttg 22801 ttaaactgaa cccttgaagc atgtccatca atacagaaat agctaataaa caaattaata 22861 tgactccagt cacgcccaat atcttcatgc ttcatcatcc tccgctttta gtgtctatcg 22921 ttggcggaga agttataccg catctaaccc taatgcataa tctcaatttt aaaaggaaga 22981 atatgagaaa acgacaaggg aaggtatttg tgtatgcctt tattttctaa gcgaaagaac 23041 aataccgatt caaaagacaa gcagaataca gacgaaagga accaggaaca gcagcaagaa 23101 aaagaaaggc cggttctcat ttctccaagt ttggcaaaga atatagcgga aacgaaaaag 23161 gaagtcggaa gcagctctga cgtcatcatt cgcgagatta aaatcgggga gcaggatcat 23221 gtccacctag ctgttatcta tattgctggg ctggtcgata ataacacgat ccatgagtcg 23281 ttaattgacc cattggtaca ggatgagtct atccagaata ctcatgcgat ccagcaaatt 23341 cttgaaaaaa cgctcccgct gggcggggtg aaagcggaaa agagctggga caagcttttt 23401 tccgagttaa tgctcggcaa tgcgctcatt tttgctgatg gccatgatga agctttgatt 23461 tgcagcactc aagggggaga gcagcgctcc atccaagagc cgagcaccca ggtgtcattc 23521 cgcggcccgc gccaagggtt tacagagtct ctgcaaacca atatttccat gatccggcga 23581 tacattaaaa atccgaattt atgggttgaa aaaatgaaaa aaggttctgt tacgaatacg 23641 gatatcgctc tcatgtacat tcaaggaata tgcgatgaaa aggtgctgaa ggaagtgaaa 23701 cagcgcctgg aaaaaataga tattgacagt attttggaat ctggatatat tgagcagctg 23761 attgaagatg aaacctttac gacgtttccg actatgtatc atacagaacg ccctgatgtt 23821 gtagcgggta atctgttaga aggaagattc gcgattattg tggacggaac accgtttgtg 23881 cttattgccc cggccttatt tgtccagttt tttcagtctg ttgaggatta ttattcgcgt 23941 tttgacattg cgacaagcat aagaattctt cgtgttttag tctttttcat ttcgcttgtg 24001 gcaccggctg gatacgtggc agccacgacg tttcatcaag aaatgatacc gactcagctg 24061 ttagtggtca ttgccgccca gcgggagatt gtcccgtttc cggctgttgt ggaggcgctg 24121 acgatggagg ttgcttttga gattctgagg gaagcgggag tcaggatgcc ccgggttgtc 24181 ggctcggcag tgtcaatcgt aggcgcgctc gtaatcggcc aggctgccgt acaggctggt 24241 atcgtctctc aggcaatggt gattatcgtg gcactaaccg cgattgcgag cttcgcaaca 24301 ccggcgtttg caatggcgat ttcagcccgg cttattcggt ttatctttat tattgcctca 24361 gctgttatgg gtttttacgg gctgatttta gggatcatta tgatgtttgt ccacttatgc 24421 agtcttcgtt cattcggcgt cccatatatg tcgccgcttg cacccttttc ttcacaaggc 24481 gtaaaggacg cgcttttcag ggttccgtgg tgggctgatg aaaaaaggcc ggaatcgatc 24541 agtaaggaag ataaggtgcg gcaggggaag gatcaacgcc cagagccggc cgcttcacga 24601 ggaatggtga acaaagattt ggaagaaggg gatcagaatg gtacgtaaat gtctattagc 24661 cgttctcatg cttttgagcg tcattgtgct gcccggctgc tgggataaga gggagctgac 24721 ggatcttgcg attatctcgg cgattggcat cgatcggaca aacgacagca actacgtgct 24781 gcatcttcaa attatcaatc caggaaatgt tgccggcggc cttcagggag gcggtgctgg 24841 agacaggccg cctgtatatg tctattcgat tgaaggtaac aatataacgg aagcactcag 24901 aaaagcctcc atgaaggtat cacggcggct ttattttgcc cataccaatc tagtcgtgat 24961 caatgaaaag ctggcaaaag aagaaggttt ggattttgta ttagataatc ttgaccggga 25021 caaagaattc aggacaacag caacattcgt cgttgcccat aaaacaaaag cagaaaatat 25081 tgtgaaaatc ttgacgccaa ttgataaaat tccatcaaat aaagtcaata aaaccttgga 25141 tttcacggag gcgcaatacg ggtgggtggt caaaaccaat attcaggacg ttttgaaaac 25201 acttgccgcc aacactatgg caccggtcat ccccggatat atgatgattg gtgacgataa 25261 aaaaggagtc agcatgg //