LOCUS       c00015_gnlPro..        14968 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDPDGBJP_44.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:00:14
            Original ID  :: gnl|Prokka|HDPDGBJP_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14968
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14968
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[324:4968]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      325..4968
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14968
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14968
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(80..286)
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MHDAPLFLFITIQICSLSLSCDLLKISLIYVFPASKNSSCKLIKQ
                     SNQPVHTLFCQFCTHLFYIEGNG"
     CDS             complement(325..1485)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_2"
                     /sec_met_domain="OAD_beta (E-value: 5.1e-152, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1487..1918)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.9e-20, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     VKPVVRPVSTSPAPAPATVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             complement(1942..2871)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_4"
                     /sec_met_domain="OAD_gamma (E-value: 4e-15, bitscore: 50.7,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLVKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATDNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSHAKMEKFEEHDGSGIGMAISAMSVVFCGLLLLFILFK
                     CVGKISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(2899..4452)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_5"
                     /sec_met_domain="CT_Btheta (E-value: 2.1e-290, bitscore:
                     957.7, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(4555..4968)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_6"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.9e-24, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             complement(5125..6147)
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSVRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEILEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKAPY
                     ERLSMSRRRQINKALRNGAIMEIADNEKDIQDFSRMLKKAYSSQIRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILSVWAPI
                     TYAYEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             6193..6729
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFIVVDDKDMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNEE
                     HLQWEKIHINKYGGK"
     CDS             6732..7058
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLTGIWLILNIGLVIALLGQMSAYLLPAALLLVGVILYL
                     VSTR"
     CDS             7058..7864
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_10"
                     /sec_met_domain="F420_oxidored (E-value: 1.5e-09, bitscore:
                     32.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLIGAGNVATHLGIALQKAGCLILQVYSRTEESASALAARLS
                     VDYTIVPDEIRRDADLYIVALKDAVLRQLAPVLVKGREQALFVHTAGSMSMDLWKGLVK
                     RYGVLYPMQTFSKQREVDFNTVPFFIEASAPAEVELLRMVAVRLSPKVYEVTSGQRRYL
                     HLAAVFACNFANHMYALSSHILEKQGIPFEVMLPLIDETAGKVHELSPTQAQTGPAVRY
                     DENVISKHLEMLADEESLQELYEKISKSIHNLPLSVIQANKEGKNS"
     CDS             7870..8388
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MINYDLKKIKALVFDVDGVLSAETIYLHPNGEPMRTVNIKDGYAL
                     QLAVKCGLHVAIITGGNTEAVRKRYEGLGIKDVYLAAAVKTREYAHLKEKYGLQDEEIL
                     YMGDDIPDYEVMRLCGLPCCPADAAPEIKETAVYISHRNGGYGCGRDVVEQVLKAQGKW
                     MAHEKAFGW"
     CDS             8406..8987
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MLENLEKYKIILASNSPRRKELLSGLGIKYEVKTLPGIEETYPDT
                     LKAEEIPLYIACEKAAAYRNTMHPDELIITADTIVWLDGVVMGKPHNEDDARQMLWKLS
                     GKTHQVITGVCLTTVGAQRSFSAVTEVTFAELSDEEIDYYIRVYKPMDKAGSYGIQEWI
                     GFIGVRGISGSYFNVMGLPVQRLYTELKKL"
     CDS             9054..10061
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_13"
                     /sec_met_domain="Hacid_dh (E-value: 5.7e-30, bitscore:
                     98.2, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Hacid_dh_C (E-value: 9.8e-57, bitscore:
                     185.6, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYKIAFYDTKPYDERSFTEANEKFGFDIRYYKGHLNMNNVVLTK
                     GVDVVCIFVNDTADAEVIRAMADNGVKLLALRCAGYNNVDLAATAGKMKVVRVPAYSPY
                     AVAEFTVALMLSLNRKIPRATMRTRDGNFSLHGLMGFDMHGKTAGIIGTGKIAKILIQI
                     LRGFGMNVLAYDLYPDYNFAREHQVVYCTLDELYHSSDIISLHCPLTEQTKYLINDYSI
                     SKMKDGVMIINTGRGQLIHTNALIEGLKTKKVGYAGLDVYEEEEPYFYEDKSDKIIDDD
                     TLARLLSFNNVIVTSHQAFFTKEAMTNIAHTTLQNVKDFAESRSLVNEVAVGRV"
     CDS             complement(10058..11227)
                     /locus_tag="ctg15_14"
                     /transl_table=11
                     /translation="MQTIKLYIKDWLAIHPYIQQQATDRYFVDLANRLYSTCTIREIPE
                     SIKKKLCLYTAAYFEDVISGLGLWQAFIKKHLELYDTSLPFYTIRPDYIKDEINEEDIR
                     FIIWNTLEKAPYKHPYINPMDRNIEETSHSFFRILDEEYETAPANDTLQDFFMDFKGKE
                     NANHKLRWLFGHTYLTEPSVQEYIAQVTETDKFIIPCGPLALFLHEWIDLLTNGETECW
                     EEIEGLYPAIPEISDEMKERNHHTYQLFTQGTNGARIVYLEGYKELHRFLTQVLQWPDD
                     SNHTLPQMKEHKDFIMMVNSEKGILLAKDICKYISDPLNPMYDAATAAQEAFSLLTIPT
                     KCPPDLMEYVINNHYIPDAQFPEFGERELVQKNADFIARNSLLYYYRGD"
     CDS             11346..11735
                     /locus_tag="ctg15_15"
                     /transl_table=11
                     /translation="MEIDLTTPALLFSAISLIMLAYTNRFLSYAQLVRTLKDQYRENHS
                     AVTAAQIANLRKRLYLTRAMQVTGIGSLLLCVVSMFLMYIQFYLISVYIFGLALVLLII
                     SLGISVREIYISVKALELHLSDMDS"
     CDS             complement(11737..12912)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 80.5; E-value: 3.8e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_16"
                     /sec_met_domain="MFS_1 (E-value: 2.2e-24, bitscore: 80.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQELKENQGLPASLLWTLAIIAGISVANLYYNQPLLNRISRDLQ
                     TSEFTANLIAMITQIGYAIGLLFIIPLGDLFKRKTIILINFTVLVVSLLTIALTPYIHL
                     ILFASLLTGICSVMPQIFIPIAAQFSTPETKGKNVGMIVSGLLTGILASRVVSGIIGEY
                     LGWRFIFFVAAGMMVICVIIIMRVLPDMPCNFKGRYSDLMKSLFSLVMEYPQLRISSLR
                     AGIAFGSFLALWTSLAFKMEQAPFFAGNNIVGLLGLCGIAGALTASYIGNYVQVLGVKR
                     LNYIGCGLIFSAWFSLYSGQNSYVGIIIGIFIIDIGMQCIQLSNQTTIFSLSPKAANRI
                     NTIFMTTYFIGGSIGTLLAGIFWHWFGWQGVVGTGITLATCSFMINIFSKK"
     CDS             12972..13493
                     /locus_tag="ctg15_17"
                     /transl_table=11
                     /translation="MKMKNWIKTVCFLLWTCVMCTACIDDDVEEGTVDLQTGESIPVFS
                     VVMDDGQIITSETLKGEVSLIVFFHTGCPDCRKELPVLQKIYTDYGRRIRMVCISREES
                     SAEIVRYWDENHLTLPYSAQENRTVYYQFAKSGIPRVYVIDKELVIRSVFTDNPLASYE
                     DLAEAITASL"
     CDS             complement(13627..13989)
                     /locus_tag="ctg15_18"
                     /transl_table=11
                     /translation="MKRILLLLVLCLNISMVLGQEYKNWEKYDIEGFYIIAKSKAEAKI
                     SKNVLREGADYYILTEMDDQVFPSGVSKKITPKLYKLKDTEIYIFFSFPPFLFDADNGM
                     IEIKDNKGTFFKKPTQ"
     CDS             complement(14089..14376)
                     /locus_tag="ctg15_19"
                     /transl_table=11
                     /translation="MGTLGCINNMMRRDKENRELRKAGKERLNETRNRLIDLNKKGHSS
                     HLSLEQLEEIRIKTQEKEEAETHQLFKIKLIMLGIVLIAGVLIWIGITFL"
ORIGIN
        1 cggacaaatt aaaaacaata tgaactacaa acgtttccga cattttggaa aggacaaggt
       61 cttcatggac tttgccttcc tagccattgc cttcaatata aaaaagatgt gtgcaaaact
      121 gacaaaaaag ggtatgaact ggctgattag actgttttat gagcttacaa ctgctgtttt
      181 tagatgctgg gaacacataa atcaaagaaa tcttcaaaag atcgcagctt aaagaaagtg
      241 aacagatttg tatagtgatg aacaaaaaaa gaggtgcatc gtgcattacg acacacctcc
      301 ttttatttat tgttgttcaa tgaattacat caagaaccca agtaaaatac cggcagctac
      361 ggcagaaccg attacaccgg ctacgttggg acccatggca tgcatcagca agtagttggt
      421 aggatcatat tccagaccga taacctgaga gatacgtgcc gagtcaggaa cagcagatac
      481 accggcatta ccgataagcg gattgatttt gttatcctta cctaatacca agttgaatat
      541 ctttacgaag ataactcccg aagcggtagc aatgatgaat gacaatgcac ccagcgcgaa
      601 aatcaaaatc gaatcaatgg taaggaattc tgaagcttgc gtggaagcac ctactgtcaa
      661 tcctaataag atggtaatgg tatcaatcag cggaccgcgg gcagtttctg ccaagcgacg
      721 ggttacaccg ctttctttca ataagttacc aaagaaaagc atacccaata gaggcagacc
      781 cgacggaacc agaaaacaag taagcaacaa accaatgata gggaacatta ctttttctgt
      841 atgagaaacg acgcgtggtg gtttcatacg gatcaaacgt tcgtgcttgg tagtgagcag
      901 acgcatgata ggcggctgga taaccggtac caatgccatg tatgaatagg cagataccgc
      961 aatagctccc atcaggttag gcgccagttt ggatgaaagg aagattgctg tcggaccgtc
     1021 cgcaccaccg atgatgccga tagcaccagc ctgcatcgga tcaaagccca ttgccaatgc
     1081 aatcatgtat gcaccgaaaa taccaaactg tgcggcagca ccaatcaaca tcagtttagg
     1141 atttgaaatc aatgccgaga aatccgtcat tgcaccgata cctaaaaaga taagtggtgg
     1201 ataccatccg gaggtaactc cttgatataa aatattaaga acagaacctt cctcatagat
     1261 gccgactttc agtccggctt ccatgttgaa aggaatatta ccgatcaaga taccgaaacc
     1321 gataggaatg agcaacatcg gctcaaattc cttggccacg gcaaggtata tgaagaataa
     1381 acctatcagg atcattacga tatgaccaac agtagcattg gcaaaacccg tatatgtcca
     1441 aaagtcagct aggttattcc ctaaaaagtt gataaattct cccatattat tcaataatta
     1501 caaggtcagt accttcgaga acggattctc ctttacttac attgattgcg gtgatcttgc
     1561 cgtctttgtc tgcattgatg ttattttcca tcttcatagc ttcaaggata atgatggttt
     1621 gccccttttt tacggtatca cccacattta ccttgatatc aaggattacc cccggcaacg
     1681 gagatttaac gcccgattta cctgtagaag ttgcagcagg ctttactact gtagctggtg
     1741 ccggagcagg gctggttgat acaggacgaa ctaccggttt cactacagct ttcggagctt
     1801 tttccatttc cactttgtaa ggagtaccgt tcacttcaac atgagcgata ttgtcttcta
     1861 tatctccaat ggcaactttg tatacgttac cgttgatctt atatttatat tctttcatca
     1921 ttttatcttt ttattggtga cttacttttt gtggggagtt tcacgcaagg tataaatctt
     1981 ggaactccac ggtgaataac tacgttttac acgggtaatg gtaagaacgg tttcttccac
     2041 gtcatgtaca tcgctttgca tttcatgcat ggccatggcg atagcggcga atacttcgcc
     2101 cggagcttca cccaatttct tttctttggc ttcttgcttg tcggtaatac cttttacctt
     2161 catggcattg cgcttgctca ggtttacaga aatcttacct acacatttga agagaatgaa
     2221 aagtaaaaga agaccgcaga atacaacgct catagcagag atggccatac cgataccact
     2281 accgtcgtgt tcttcgaatt tttccatctt tgcatgactg ttgatagtct tgttattggt
     2341 gctcggagtc acatatttgt ctgcgctgga acctttcacc tcccattcat ttgctgcgtc
     2401 gctgacacgt gcgtatgatt ggtttgcttg caatgtgcct gccggaacaa taatctgatc
     2461 caataatttt ttgcctgaat catacaatcc aatccaattg tcggttgcgg cattcagtgt
     2521 gaaattagtg tggaaagtac cgcggttggg ttcgccgtct gcccagaata aagcgtgctg
     2581 gcgaggtttg accaaagtca atacatcacc tttagggata aaataagtag cagtatctcc
     2641 aggctggctg ctcaccttca gtaaacaacc ggcaaggtct gcgctaccaa atgatctgtt
     2701 gaatatttca atccatgcgc tgtgtactcc gtagtcatcc tggaaattgc tttcattttc
     2761 aatcagcact tcattcagta ccagcttggt gttcgatttc tgttctccac aagaacataa
     2821 ccccaccatc agcagcaaag aaaggaatat tcctatattt aatttcttca tgttcaattc
     2881 tcagttttta atttttaatt aaagaggaat attaccatgc ttcttagccg gattggttaa
     2941 tttcttagtc tgcaactgtt gcaatgcacg gatgatgcgg aaacgggtat tacgcggttc
     3001 aatcacatca tcaatgtaac catatttggc agcattgtaa ggattggcga acagcttggt
     3061 gtattcagct tctttttcgg ctaggaatgc ggcaggattt tcctgttctt tggcttcgcg
     3121 tgcgtataat acttctactg cacctgcacc acccataacg gcgatttcgg cagtaggcca
     3181 tgcataattc atatcaccgc gaagttgttt acagctcatt acaatgtgag atccgccgta
     3241 tgatttacgc agggtaattg tcactttggg tacagtcgct tcgccgtaag catacagcaa
     3301 cttggcaccg tggaggatta caccgttgta ttcttgtcct gtacccggaa ggaatcccgg
     3361 aacatctacc aatgaaacaa gaggtatatt gaaagcgtcg cagaaacgta caaaacgagc
     3421 acctttgcgt gacgcattgc tgtcaagcac acccgccagg tatttgggct ggttggcaac
     3481 aatacctaca gactggccgt tgaaacgtgc gaaaccaatg atgatatttt tagcgtagtg
     3541 aggttggact tccaaaaact caccattatc tacgatggcg ctgatcacct catacatatc
     3601 gtatggtttg ttggggctgt cggggataat ttcgttcaaa gagtcttcca gacggtcgat
     3661 aggatcggta cagtctacat agggagcttc ttccagattg ttctgaggaa tatagcttaa
     3721 caatttgcgg atcatggcta acccttcttc ttccgtcttg gctgtaaaat gagtaacacc
     3781 ggatttggtt gaatgaacgc ttgcaccacc taagttttcc tggcttacat cttcacctgt
     3841 aacagtcttt accactttcg gtccggtaag gaacatatat gatgtgcctt ccatcatcaa
     3901 ggtgaagtct gtcagagcag gagagtaaac agctccgcct gcacaaggac cgaaaatacc
     3961 tgagatctgc ggaataacac ctgaagcaag aatattgcgt tggaaaattt cagcataacc
     4021 ggccaatgca ttgatacctt cttgaatacg tgcgccaccc gagtcgttga taccgataca
     4081 gggagcaccc attttcatag cttgatccat tactttgcat attttcagag acattgtttc
     4141 tgaaagagaa ccggcagaaa cagtgaaatc ctgtgcaaag atgtaaacta aacgtccttc
     4201 tatggtacca caacctgtta ctacaccgtc gcccggataa tgttttttct ccatgccgaa
     4261 attggtgcat ctgtgttcca caaacatatc catttcttcg aaactgccct catccagcag
     4321 catggctatg cgttcgcggg ctgtatattt tcctttatca tgctgttttg caattgcttt
     4381 atcacctcca cccatgcgtg ctgtagcccg gcgttcgata agctctttta ttttttcaag
     4441 ttgattgctc attttactta tgattttaca atttacgatt aaaaaataat tctatttacg
     4501 cttgaaccag actaaatata ctgacttcaa tcgtgaatag tcagatctcg tgttttatgg
     4561 tttttcgcaa agctcggtca ggacgcccaa agttgatttg ggatgtaaaa aagcaatttg
     4621 caaaccttcg gcacctttac gcggagcttt gtcaatgaga cggatgccgg tggtttcagc
     4681 ttcggctaac gcatttgcca caccatcttc cactgcaaaa gccaaatgat gcataccacc
     4741 gttgccatta tttttttcaa tgaactttgc gatagtgctt tcggggcttg taggttccag
     4801 cagttctatt ttaacatcac ctactttcag aaaagcggtt ttaactttct gatcctctac
     4861 tgtttcgata ttgtagcatt tcagacctaa tacgttttca taatacggca gggcctcttc
     4921 aatgctcttt acggcaatgc ccaggtgttc aatgtgtgag attttcatga tcttataatt
     4981 ttaatagttt ggttttatac tcaagttttc agataaaact gcacaaagaa agtaatttcg
     5041 agttaaataa agaaatattt cttcaatttt atttcttatt tgcaagatgc ttcacaacac
     5101 tttagacaaa aagacaaaaa tgagttaaat atagaatttg cacaagagtt tgttcagcca
     5161 cttccaactg aagcggaacc agcggcgtgt actgctctgc ttgccgccaa agcggagtat
     5221 aaagtccctg taaccgtgct ttttgaacgg taatcctgca tccatgaatt ccaaatgtgc
     5281 atatcctttt tcgtaagcat aggtaatagg tgcccatacg gacagaatac cggggtaaag
     5341 aaaagcatag gttttccgca tacctcctga gaaccacagg taggcacttt cttttgagaa
     5401 aagacagata gaaccaccga tgattttgcc tttatatttc acaagaaaca ctttggctaa
     5461 ttctttttcc gggttctgcc atgctaataa ccggaaaaag ccgatgtccg ggaaatgttt
     5521 tcttatctgt gaggaatagg cttttttcaa cattcgtgag aaatcttgta tatctttctc
     5581 attgtcggct atttccatga tggcaccatt tctcagagct ttgtttattt gtcttctgcg
     5641 agacatgctc agccgttcgt aaggagcttt actgtgcagt gaattacgta ctcttagcca
     5701 attaatggcg aaatagttgt tctttctgaa agctttgtat ccgaatagcg gattttccaa
     5761 gttgcggaac tcgatgagga acgatttgca taatacttcg ttggtgagat gttccaatat
     5821 ttccccgaac aggtcttcct tattctgttc ttcatcaaaa tactcgcctg tgccataaat
     5881 ttcgcatcgt ttgatgattg caggggggaa caggcgcaca cttttccgga tgactgccag
     5941 cagtttgcct acaggacggt ttcctatata ggctacgata agcaaaggtt cgtatccccg
     6001 ggtcatttca aagacatgaa acagctcggt agaatggaaa atgtttgttc ccggcagagg
     6061 gggaatggca tttcctttgc gatatgtact taatctgaca ggcatctcta attgcaaatt
     6121 tattgttttt tgtttatcaa tccacattct agttgtatat ttgtgcagaa aaataaatta
     6181 acagggtata ttatggaaca atttagtgac ttaataaaga acagacgcag catgcgtaag
     6241 ttcacggatc aagagttgac acaggaagag gtagttgctt tgttgaaggc tgctttgatg
     6301 gctccgtctt ctaaacgtag taattgctgg cagtttattg tggtagatga taaggatatg
     6361 ttggaaaaac tttcccattg taaggagatg ggggcggctt tcctagcgga tgctgctatg
     6421 gctgtagttg tgatggctga tccgttggct agtgatgtct ggattgaaga tgcgtcaatt
     6481 gcttccataa tgatccagtt gcaggcagaa gatttggggt tgggaagttg ttggatacag
     6541 gtgcgtgaac gttttaccgc taccgggatg ccctcgggtg aatacgtgca tacgttgctt
     6601 gatattccgt tgcagttgca ggtggtttcc attatagcgg tagggcataa gggtatggaa
     6661 cgcaagcctt ttaatgagga gcatttacaa tgggagaaaa ttcacattaa taaatatgga
     6721 ggcaagtaaa cgtggctgct gtcaatcata aggatacgta taaagcttct gcggtgtttc
     6781 tcattgtgat ggggatgctt tatctgatcg ataagtttat aggatttgct tcacacgggt
     6841 tgccatgggt tatgcagaaa gacaatctgt tactgtatgc agctgttatt ttcctttggt
     6901 tcaaggctga taagtcagta ggaattgtat tgacgggtat atggctgata ttgaatatcg
     6961 gtttggtgat agctttgttg ggacagatgt ctgcttattt gttgccggcg gctttgttgc
     7021 tggtgggagt tattttatat ttagtttcga cccgatgatg aaaatagttc tgataggagc
     7081 tggcaatgtg gcaacccatc tgggaattgc tttacaaaag gcggggtgtc ttatcttgca
     7141 ggtatacagc cgtacagagg aatctgcttc tgcattggct gccagacttt cagtagacta
     7201 cactattgtg ccggacgaga tacgtcggga tgccgatttg tatattgtag cgctgaaaga
     7261 tgcagttttg cgacaattgg ctcctgtatt ggtgaaagga agggagcagg ccttgtttgt
     7321 acatacggcg ggtagtatgt ctatggattt atggaaggga ttggtaaaac gctatggggt
     7381 actttatcct atgcagactt ttagcaagca gcgtgaagtg gatttcaata ctgtaccttt
     7441 ttttatagaa gcatctgctc cggcagaagt ggaattgctg cgtatggtgg cagttcgtct
     7501 cagtcctaaa gtgtatgaag tgacttccgg gcaacgtagg tatttgcatc tggcggcagt
     7561 ctttgcttgt aattttgcaa accatatgta tgcattaagt tcacatatac tggaaaagca
     7621 ggggattcct tttgaagtga tgcttccgct gatagacgaa actgccggca aagtacatga
     7681 actttctccc acacaggcgc agacaggtcc ggctgtacgc tacgatgaaa acgtaataag
     7741 caaacatttg gagatgttgg cggatgagga gtctttgcag gaattgtacg aaaagataag
     7801 taaaagtatt cataatctcc ctttgtctgt cattcaggca aataaagagg gaaagaactc
     7861 ataagtggta tgataaacta tgatttaaag aaaataaagg cattggtatt tgatgtagat
     7921 ggggtattga gtgcggaaac tatttatttg caccccaatg gtgaacccat gcgtacggtt
     7981 aatatcaagg atgggtatgc attgcagttg gctgtgaaat gcgggctgca tgttgccatc
     8041 attaccggtg gaaataccga ggcggtgcgt aagcgttatg aggggctggg tatcaaagat
     8101 gtctatctgg ctgctgcggt gaagacccgg gagtatgccc atttgaagga aaaatatgga
     8161 ttgcaggatg aggagatact ctatatgggc gatgatattc ccgattatga agtgatgcgt
     8221 ttgtgtgggc tgccttgttg tcctgctgat gcggcacctg agataaagga aacagctgtt
     8281 tatatttctc atcgtaacgg gggatatgga tgtggccgtg acgtggtgga acaggtcttg
     8341 aaggctcaag gaaaatggat ggctcatgaa aaggccttcg ggtggtaatg aaataaagaa
     8401 aagttatgtt ggaaaattta gaaaaatata aaataatcct tgcttccaat tctccgcgcc
     8461 gcaaagaatt gttatccggc ttaggtataa aatatgaagt aaaaacacta cccggcatag
     8521 aggaaaccta tccggataca ttgaaagcag aggaaatccc tttgtatata gcttgcgaaa
     8581 aggcggctgc ttaccggaat accatgcatc cggacgaatt gattattact gccgatacca
     8641 ttgtatggtt ggatggtgta gtcatgggca agcctcataa cgaggatgat gcacggcaaa
     8701 tgttgtggaa gctttccggc aagacccatc aggtgataac cggagtttgt ctgactaccg
     8761 tcggggctca gcgaagtttt tcagctgtga cagaagtaac gtttgcagaa ttgtccgatg
     8821 aggagatcga ttattatatc cgggtttaca agccgatgga taaggctggt tcttatggta
     8881 tacaagagtg gataggtttc attggtgtcc gtggtatttc aggtagttac ttcaatgtga
     8941 tggggcttcc tgtacagcgc ctgtacacgg aactgaaaaa actataagtc agtatgtgaa
     9001 cagtaggggc cgtgtttttg ttatttatat gaactataaa tggaaaaaca attatggctt
     9061 ataaaatagc tttttacgac acgaaaccct acgacgaacg ctcgtttacg gaggctaatg
     9121 agaagtttgg ctttgatatc aggtattaca aaggccattt gaatatgaat aacgtggtgt
     9181 tgaccaaagg agtggatgtg gtttgtatct tcgtaaacga tacggctgat gccgaagtta
     9241 tccgggcaat ggcggataat ggtgttaaac tgctggcttt aagatgcgca ggttataata
     9301 atgtggattt agcggcaacg gcaggtaaga tgaaagtggt acgggtaccg gcttattcac
     9361 cttatgccgt tgccgaattt acggtggcgt tgatgttatc actcaaccgc aagattcccc
     9421 gtgctacaat gcggacacgt gacgggaatt tctccctgca cgggcttatg ggatttgata
     9481 tgcatggcaa gactgccgga attatcggta cgggtaagat tgccaagatt ttaattcaga
     9541 tattacgtgg attcggtatg aatgttcttg catatgatct ttatcccgat tacaattttg
     9601 cccgtgaaca tcaggtggtt tattgtactt tggatgaact ttatcatagt tcggatatca
     9661 tctccctgca ttgtcctttg acagaacaga caaagtatct gattaatgat tattccatca
     9721 gtaaaatgaa agacggagtg atgattatca atacggggcg tgggcagttg attcacacca
     9781 atgccttgat agagggactg aagactaaaa aggtaggata tgccggtctg gatgtatacg
     9841 aggaagaaga gccttatttt tatgaagata agtccgacaa gattattgat gatgacactt
     9901 tagcccgtct tttgtctttc aacaatgtga ttgtgacttc tcatcaggca ttctttacca
     9961 aagaagcaat gacgaatatt gctcatacta ctctgcaaaa tgtgaaagac tttgctgaaa
    10021 gtagatcttt ggtgaacgaa gtagcggtgg ggagagtcta atctcccctg tagtaatata
    10081 ataaggagtt gcgggctata aagtccgcat tcttttgaac cagttccctt tcaccaaatt
    10141 cggggaattg tgcatcgggg atatagtggt tgtttattac atattccatc aggtccggtg
    10201 ggcatttggt cgggatagta agcaggctga atgcctcttg ggcagccgtt gcggcatcat
    10261 acatcgggtt aagagggtca ctgatgtatt tgcatatatc tttcgccagt agaatacctt
    10321 tttcggaatt caccatcatg atgaaatcct tatgttcctt catttggggc aaagtgtgat
    10381 tggaatcgtc cggccattgt aatacttggg taaggaaacg gtgtagttcc ttatatcctt
    10441 ccagatatac gatacgggca ccgtttgtgc cttgcgtgaa caattgatag gtatggtggt
    10501 tcctttcctt catttcatcc gatatttcgg gaatggcagg gtatagtcct tctatctctt
    10561 cccaacattc ggtttctccg ttggtcagca ggtcaatcca ttcatgaaga aacagggcaa
    10621 gggggccaca tggaatgatg aatttgtcgg tttctgtaac ctgtgcaata tattcttgta
    10681 cagatggttc tgtgagataa gtatgtccga acagccagcg tagtttatgg tttgcgttct
    10741 cttttccttt gaagtccata aagaaatcct gtaacgtgtc attggcggga gccgtttcat
    10801 actcttcatc caatatccgg aaaaatgaat gcgaggtttc ttcgatattc ctgtccatcg
    10861 gattgatata cggatgttta tatggagcct tctctaaagt gttccaaatg atgaagcgga
    10921 tatcttcttc attgatctca tcttttatat aatccggccg gatggtatag aaaggaagtg
    10981 acgtatcata tagttccaga tgttttttga tgaatgcttg ccatagacct aaacctgaaa
    11041 tgacatcttc aaaataggca gcggtgtaaa gacataattt cttttttatg gattcgggaa
    11101 tctctcttat cgtacaagtg gagtataatc ggttagccag atcgacaaaa tatctgtctg
    11161 tagcctgttg ttggatgtaa ggatggatag ccaaccaatc ttttatgtat aattttatgg
    11221 tttgcatatt agtttatttg aattattttt attgcaaaga tattcctttc attgtaaaaa
    11281 ggaaggagaa tatcgggata tttactttat ctttgcaata ttctaacttt gaaataccta
    11341 taaaaatgga aatagattta acaactcctg ctttattatt ttctgccata tcgctgatta
    11401 tgttggcata tactaatcgt tttctttcat acgctcaatt agtgcgtacg ttgaaggacc
    11461 aatatcgtga gaatcattcg gctgtgacag cagcacagat tgctaatctc cgcaagcgtc
    11521 tttatctgac acgtgccatg caggtgacag gtatcggaag tttgttgctt tgtgtggtca
    11581 gtatgttttt aatgtatata cagttctacc ttatatccgt atatattttt ggactggcgc
    11641 ttgtgctgct cattatttct ttggggattt ctgtgcgcga gatttatatt tcggtcaagg
    11701 cgctggaatt gcatctaagc gatatggatt cctgatttat ttttttgaaa agatatttat
    11761 cataaaggaa caggttgcca gtgtgatacc tgttcctact actccctgcc atccaaacca
    11821 gtgccaaaat attccggcaa gaagtgtacc tatggaaccg ccaataaaat aggtcgtcat
    11881 aaaaatggtg ttgatacggt tggccgcctt cgggctaaga gagaaaatcg tagtctgatt
    11941 actcaattgg atgcattgca tgcctatatc tatgataaaa attccgatga tgattcccac
    12001 ataggagttc tgaccggaat aaagcgagaa ccacgctgaa aatatcaaac cacaaccgat
    12061 gtaattcagt cgtttgactc ccaaaacctg tacatagttt cctatatacg aggcggtgag
    12121 agctcctgct atgccgcata atcccaataa ccctacaatg ttgtttcccg caaaaaaagg
    12181 ggcttgttcc atcttaaatg ccaatgaagt ccatagagca agaaatgagc cgaaagcaat
    12241 tccggcacgt aaggaagaaa tacgcaactg ggggtattcc ataaccaatg aaaacaagga
    12301 tttcatcaga tcactgtatc tgcctttgaa attacacggc atgtcgggta gtacacgcat
    12361 gatgatgatg acacatatca ccatcatccc ggctgccaca aagaaaatga accgccatcc
    12421 taaatattca ccgataattc cgcttactac gcgcgaggcc aggatacctg tcagcaatcc
    12481 cgatacaatc atacctacat tttttccctt ggtttcggga gtggaaaatt gggcagctat
    12541 ggggataaag atttgtggca tcaccgaaca aatgccggtc agtagagagg caaataaaat
    12601 gagatggata tagggagtca gtgcgatggt tagtaatgaa acgaccagga ctgtgaaatt
    12661 gattagaata atggttttcc ttttaaataa atctcccaaa ggaataatga acagcaatcc
    12721 gatggcataa cctatttggg taatcattgc tatcaggttg gcggtgaact cggatgtttg
    12781 gagatcacgg ctgatgcggt ttaataaagg ttggttataa tataaattgg caacggagat
    12841 tcccgcaata attgctagcg tccaaagtaa ggaggcaggt agtccttggt tttcttttaa
    12901 ttcttgtttc atgctgcaaa agtagtaatt tcatgaaaat catgttatct ttgtaaagaa
    12961 gaaaaatggg aatgaaaatg aagaattgga taaaaacggt ctgttttctg ctttggacct
    13021 gtgtaatgtg tacggcgtgt attgatgatg atgtggagga aggtactgtt gatttacaaa
    13081 caggagagag cattcctgtt ttctctgtgg taatggatga tggacaaata ataacttccg
    13141 aaactctgaa aggagaggtt tctttgattg tgttttttca tacggggtgt ccggactgtc
    13201 ggaaagaact tcctgtgctg caaaaaatat atacggatta cggtcgaaga atccggatgg
    13261 tttgtattag cagggaagag agctcggcag agattgtccg ttattgggac gaaaatcatt
    13321 tgaccttgcc ctattcggcc caagaaaacc gcacggtata ctatcagttt gctaaatcgg
    13381 gaatacctcg tgtttatgtc atagataaag agttggttat ccgtagtgtt ttcacggata
    13441 acccgttggc aagttatgaa gatttggctg aggctataac cgccagtttg taattttagg
    13501 catggtattt taatttatat tatttctttt gtggatggtg tatgtttata gcatactttt
    13561 ccctcttcat ctttagggat aatgaatgtg gttgatgaag atattggtga tggagtatct
    13621 tgatgtttat tgtgttggct ttttgaaaaa agttccttta ttgtctttaa tctctatcat
    13681 tccattatcg gcatcaaata ggaaaggagg aaagctgaaa aatatgtata tttcagtatc
    13741 ttttaattta tagagtttgg gagttatttt tttgctgaca ccagatggga atacttggtc
    13801 atccatttcg gtgaggatat aataatctgc tccctccctc aatacatttt tgctaatctt
    13861 ggcttctgct tttgatttgg caataatata gaatccctct atatcatatt tttcccaatt
    13921 tttatactct tgtccaagca ccatacttat gtttaaacat aaaaccagta gtaataatat
    13981 tcttttcata tctatctgtt tttaaggtta ttccaagttg gtatcacaaa tataagaatt
    14041 cttattggtt ttttcaagga ataagaaaga aaaatagaga gtggaatttt aaagaaaagt
    14101 aattcctatc catatcagaa ctcctgctat tagaacaatg cctaacatga ttaattttat
    14161 tttgaagagc tggtgggttt ccgcttcttc tttttcttgc gtttttattc tgatctcttc
    14221 taattgctca agggatagat gggaggagtg cccttttttg ttcaaatcaa tcagtcggtt
    14281 tctagtttca ttcaagcgtt cctttcctgc ctttcgtagt tcacgatttt ctttatctct
    14341 tctcatcatg ttattgatgc aacctaaagt acccataatc taactgttta atttgaattc
    14401 attttcacaa atatagtgtt ttttgcagtt gcttttcttc atttgctaat ttaatatttg
    14461 aaggatagat attacttaat aaacctgatg tgccttgact gccggatata aatattctgc
    14521 caatggattt gtaatataaa gttgtatgcc attatgcttt cataccattg cttatggggt
    14581 aatatgttga taatgaactg tatttatatg gcgtggcatt ttccccattg aaataggtaa
    14641 aaagtagatg tatttatctt atcattgaaa aaaaatgtga atataaagtt taggtgaaag
    14701 tgattttatt tgtaaattgt ataccgtcat gtaggtatct ccgatctatg tataatttag
    14761 tatataccta gaaatgggga ttgtgccgag cttttatgaa ttgtaatttt gcaaaccaat
    14821 agagaatgaa atgatttgta agattgcata tattttttta tttataattt gtagcaatgt
    14881 gtctctttta tgggggcaga catttgtatt tcggggaact gtactggatg agcagactca
    14941 taaagcgttg gattacgcta cagttcaa
//
