LOCUS       c00018_gnlPro..        15686 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EEOGJDHE_53.
ACCESSION   c00018_gnlPro..
VERSION     c00018_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:15:11
            Original ID  :: gnl|Prokka|EEOGJDHE_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 395176
            Orig. end    :: 410862
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15686
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[405176:409820]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14644
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15686
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15686
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="3"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             593..880
                     /locus_tag="ctg18_330"
                     /transl_table=11
                     /translation="MGTLGCINNMMRRDKENRELRKAGKERLNETRNRLIDLNKKGHSS
                     HLSLEQLEEIRIKTQEKEEAETHQLFKIKLIMLGIVLIAGVLIWIGITFL"
     CDS             980..1342
                     /locus_tag="ctg18_331"
                     /transl_table=11
                     /translation="MKRILLLLVLCLNISMVLGQEYKNWEKYDIEGFYIIAKSKAEAKI
                     SKNVLREGADYYILTEMDDQVFPSGVSKKITPKLYKLKDTEIYIFFSFPPFLFDADNGM
                     IEIKDNKGTFFKKPTQ"
     CDS             complement(1476..1997)
                     /locus_tag="ctg18_332"
                     /transl_table=11
                     /translation="MKMKNWIKTVCFLLWTCVMCTACIDDDVEEGTVDLQTGESIPVFS
                     VVMDDGQIITSETLKGEVSLIVFFHTGCPDCRKELPVLQKIYTDYGRRIRMVCISREES
                     SAEIVRYWDENHLTLPYSAQENRTVYYQFAKSGIPRVYVIDKELVIRSVFTDNPLASYE
                     DLAEAITASL"
     CDS             2057..3232
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 80.5; E-value: 3.8e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_333"
                     /sec_met_domain="MFS_1 (E-value: 2.2e-24, bitscore: 80.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQELKENQGLPASLLWTLAIIAGISVANLYYNQPLLNRISRDLQ
                     TSEFTANLIAMITQIGYAIGLLFIIPLGDLFKRKTIILINFTVLVVSLLTIALTPYIHL
                     ILFASLLTGICSVMPQIFIPIAAQFSTPETKGKNVGMIVSGLLTGILASRVVSGIIGEY
                     LGWRFIFFVAAGMMVICVIIIMRVLPDMPCNFKGRYSDLMKSLFSLVMEYPQLRISSLR
                     AGIAFGSFLALWTSLAFKMEQAPFFAGNNIVGLLGLCGIAGALTASYIGNYVQVLGVKR
                     LNYIGCGLIFSAWFSLYSGQNSYVGIIIGIFIIDIGMQCIQLSNQTTIFSLSPKAANRI
                     NTIFMTTYFIGGSIGTLLAGIFWHWFGWQGVVGTGITLATCSFMINIFSKK"
     CDS             complement(3234..3623)
                     /locus_tag="ctg18_334"
                     /transl_table=11
                     /translation="MEIDLTTPALLFSAISLIMLAYTNRFLSYAQLVRTLKDQYRENHS
                     AVTAAQIANLRKRLYLTRAMQVTGIGSLLLCVVSMFLMYIQFYLISVYIFGLALVLLII
                     SLGISVREIYISVKALELHLSDMDS"
     CDS             3742..4911
                     /locus_tag="ctg18_335"
                     /transl_table=11
                     /translation="MQTIKLYIKDWLAIHPYIQQQATDRYFVDLANRLYSTCTIREIPE
                     SIKKKLCLYTAAYFEDVISGLGLWQAFIKKHLELYDTSLPFYTIRPDYIKDEINEEDIR
                     FIIWNTLEKAPYKHPYINPMDRNIEETSHSFFRILDEEYETAPANDTLQDFFMDFKGKE
                     NANHKLRWLFGHTYLTEPSVQEYIAQVTETDKFIIPCGPLALFLHEWIDLLTNGETECW
                     EEIEGLYPAIPEISDEMKERNHHTYQLFTQGTNGARIVYLEGYKELHRFLTQVLQWPDD
                     SNHTLPQMKEHKDFIMMVNSEKGILLAKDICKYISDPLNPMYDAATAAQEAFSLLTIPT
                     KCPPDLMEYVINNHYIPDAQFPEFGERELVQKNADFIARNSLLYYYRGD"
     CDS             complement(4908..5915)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_336"
                     /sec_met_domain="Hacid_dh (E-value: 5.7e-30, bitscore:
                     98.2, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Hacid_dh_C (E-value: 9.8e-57, bitscore:
                     185.6, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYKIAFYDTKPYDERSFTEANEKFGFDIRYYKGHLNMNNVVLTK
                     GVDVVCIFVNDTADAEVIRAMADNGVKLLALRCAGYNNVDLAATAGKMKVVRVPAYSPY
                     AVAEFTVALMLSLNRKIPRATMRTRDGNFSLHGLMGFDMHGKTAGIIGTGKIAKILIQI
                     LRGFGMNVLAYDLYPDYNFAREHQVVYCTLDELYHSSDIISLHCPLTEQTKYLINDYSI
                     SKMKDGVMIINTGRGQLIHTNALIEGLKTKKVGYAGLDVYEEEEPYFYEDKSDKIIDDD
                     TLARLLSFNNVIVTSHQAFFTKEAMTNIAHTTLQNVKDFAESRSLVNEVAVGRV"
     CDS             complement(5982..6563)
                     /locus_tag="ctg18_337"
                     /transl_table=11
                     /translation="MLENLEKYKIILASNSPRRKELLSGLGIKYEVKTLPGIEETYPDT
                     LKAEEIPLYIACEKAAAYRNTMHPDELIITADTIVWLDGVVMGKPHNEDDARQMLWKLS
                     GKTHQVITGVCLTTVGAQRSFSAVTEVTFAELSDEEIDYYIRVYKPMDKAGSYGIQEWI
                     GFIGVRGISGSYFNVMGLPVQRLYTELKKL"
     CDS             complement(6581..7099)
                     /locus_tag="ctg18_338"
                     /transl_table=11
                     /translation="MINYDLKKIKALVFDVDGVLSAETIYLHPNGEPMRTVNIKDGYAL
                     QLAVKCGLHVAIITGGNTEAVRKRYEGLGIKDVYLAAAVKTREYAHLKEKYGLQDEEIL
                     YMGDDIPDYEVMRLCGLPCCPADAAPEIKETAVYISHRNGGYGCGRDVVEQVLKAQGKW
                     MAHEKAFGW"
     CDS             complement(7105..7911)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_339"
                     /sec_met_domain="F420_oxidored (E-value: 1.5e-09, bitscore:
                     32.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLIGAGNVATHLGIALQKAGCLILQVYSRTEESASALAARLS
                     VDYTIVPDEIRRDADLYIVALKDAVLRQLAPVLVKGREQALFVHTAGSMSMDLWKGLVK
                     RYGVLYPMQTFSKQREVDFNTVPFFIEASAPAEVELLRMVAVRLSPKVYEVTSGQRRYL
                     HLAAVFACNFANHMYALSSHILEKQGIPFEVMLPLIDETAGKVHELSPTQAQTGPAVRY
                     DENVISKHLEMLADEESLQELYEKISKSIHNLPLSVIQANKEGKNS"
     CDS             complement(7911..8237)
                     /locus_tag="ctg18_340"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLTGIWLILNIGLVIALLGQMSAYLLPAALLLVGVILYL
                     VSTR"
     CDS             complement(8240..8776)
                     /locus_tag="ctg18_341"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFIVVDDKDMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDASIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNEE
                     HLQWEKIHINKYGGK"
     CDS             8822..9844
                     /locus_tag="ctg18_342"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSVRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEILEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKAPY
                     ERLSMSRRRQINKALRNGAIMEIADNEKDIQDFSRMLKKAYSSQIRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILSVWAPI
                     TYAYEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             10001..10414
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_343"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.9e-24, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             10517..12070
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_344"
                     /sec_met_domain="CT_Btheta (E-value: 2.1e-290, bitscore:
                     957.7, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHDKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12098..13027
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_345"
                     /sec_met_domain="OAD_gamma (E-value: 4e-15, bitscore: 50.7,
                     seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLVKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATDNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSHAKMEKFEEHDGSGIGMAISAMSVVFCGLLLLFILFK
                     CVGKISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             13051..13482
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_346"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1e-19, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     VKPVVRPVSTSPAPAPATVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             13484..14644
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_347"
                     /sec_met_domain="OAD_beta (E-value: 5.2e-152, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(14737..15684)
                     /locus_tag="ctg18_348"
                     /transl_table=11
                     /translation="LEEHRDKLQEYDNRLDTLQDRNSYSKTDNDATFMRMKEDAMRNGQ
                     TKPGYNLQIGTENQFITDFALFPNPTDTLTLIPFLQSFSNRYDRMAHTVVADSGYGSEE
                     NYRFMSENGMEAYVKYNYFHMEQRPRFKPDPFKAENFYYNEEHDFCICPMGQRMRRIGT
                     RNVKTASGYVNENARYRAVRCEGCPLRCRCFKAKGNRTIELNHRLRQYKRRAKELLCSE
                     KGLKHRGQRCIEPEAVFGQIKNNMNYKRFRHFGKDKVFMDFAFLAIAFNIKKMCAKLTK
                     KGMNWLIRLFYELTTAVFRCWEHINQRNLQKIAA"
ORIGIN
        1 ttgaactgta gcgtaatcca acgctttatg agtctgctca tccagtacag ttccccgaaa
       61 tacaaatgtc tgcccccata aaagagacac attgctacaa attataaata aaaaaatata
      121 tgcaatctta caaatcattt cattctctat tggtttgcaa aattacaatt cataaaagct
      181 cggcacaatc cccatttcta ggtatatact aaattataca tagatcggag atacctacat
      241 gacggtatac aatttacaaa taaaatcact ttcacctaaa ctttatattc acattttttt
      301 tcaatgataa gataaataca tctacttttt acctatttca atggggaaaa tgccacgcca
      361 tataaataca gttcattatc aacatattac cccataagca atggtatgaa agcataatgg
      421 catacaactt tatattacaa atccattggc agaatattta tatccggcag tcaaggcaca
      481 tcaggtttat taagtaatat ctatccttca aatattaaat tagcaaatga agaaaagcaa
      541 ctgcaaaaaa cactatattt gtgaaaatga attcaaatta aacagttaga ttatgggtac
      601 tttaggttgc atcaataaca tgatgagaag agataaagaa aatcgtgaac tacgaaaggc
      661 aggaaaggaa cgcttgaatg aaactagaaa ccgactgatt gatttgaaca aaaaagggca
      721 ctcctcccat ctatcccttg agcaattaga agagatcaga ataaaaacgc aagaaaaaga
      781 agaagcggaa acccaccagc tcttcaaaat aaaattaatc atgttaggca ttgttctaat
      841 agcaggagtt ctgatatgga taggaattac ttttctttaa aattccactc tctatttttc
      901 tttcttattc cttgaaaaaa ccaataagaa ttcttatatt tgtgatacca acttggaata
      961 accttaaaaa cagatagata tgaaaagaat attattacta ctggttttat gtttaaacat
     1021 aagtatggtg cttggacaag agtataaaaa ttgggaaaaa tatgatatag agggattcta
     1081 tattattgcc aaatcaaaag cagaagccaa gattagcaaa aatgtattga gggagggagc
     1141 agattattat atcctcaccg aaatggatga ccaagtattc ccatctggtg tcagcaaaaa
     1201 aataactccc aaactctata aattaaaaga tactgaaata tacatatttt tcagctttcc
     1261 tcctttccta tttgatgccg ataatggaat gatagagatt aaagacaata aaggaacttt
     1321 tttcaaaaag ccaacacaat aaacatcaag atactccatc accaatatct tcatcaacca
     1381 cattcattat ccctaaagat gaagagggaa aagtatgcta taaacataca ccatccacaa
     1441 aagaaataat ataaattaaa ataccatgcc taaaattaca aactggcggt tatagcctca
     1501 gccaaatctt cataacttgc caacgggtta tccgtgaaaa cactacggat aaccaactct
     1561 ttatctatga cataaacacg aggtattccc gatttagcaa actgatagta taccgtgcgg
     1621 ttttcttggg ccgaataggg caaggtcaaa tgattttcgt cccaataacg gacaatctct
     1681 gccgagctct cttccctgct aatacaaacc atccggattc ttcgaccgta atccgtatat
     1741 attttttgca gcacaggaag ttctttccga cagtccggac accccgtatg aaaaaacaca
     1801 atcaaagaaa cctctccttt cagagtttcg gaagttatta tttgtccatc atccattacc
     1861 acagagaaaa caggaatgct ctctcctgtt tgtaaatcaa cagtaccttc ctccacatca
     1921 tcatcaatac acgccgtaca cattacacag gtccaaagca gaaaacagac cgtttttatc
     1981 caattcttca ttttcattcc catttttctt ctttacaaag ataacatgat tttcatgaaa
     2041 ttactacttt tgcagcatga aacaagaatt aaaagaaaac caaggactac ctgcctcctt
     2101 actttggacg ctagcaatta ttgcgggaat ctccgttgcc aatttatatt ataaccaacc
     2161 tttattaaac cgcatcagcc gtgatctcca aacatccgag ttcaccgcca acctgatagc
     2221 aatgattacc caaataggtt atgccatcgg attgctgttc attattcctt tgggagattt
     2281 atttaaaagg aaaaccatta ttctaatcaa tttcacagtc ctggtcgttt cattactaac
     2341 catcgcactg actccctata tccatctcat tttatttgcc tctctactga ccggcatttg
     2401 ttcggtgatg ccacaaatct ttatccccat agctgcccaa ttttccactc ccgaaaccaa
     2461 gggaaaaaat gtaggtatga ttgtatcggg attgctgaca ggtatcctgg cctcgcgcgt
     2521 agtaagcgga attatcggtg aatatttagg atggcggttc attttctttg tggcagccgg
     2581 gatgatggtg atatgtgtca tcatcatcat gcgtgtacta cccgacatgc cgtgtaattt
     2641 caaaggcaga tacagtgatc tgatgaaatc cttgttttca ttggttatgg aataccccca
     2701 gttgcgtatt tcttccttac gtgccggaat tgctttcggc tcatttcttg ctctatggac
     2761 ttcattggca tttaagatgg aacaagcccc tttttttgcg ggaaacaaca ttgtagggtt
     2821 attgggatta tgcggcatag caggagctct caccgcctcg tatataggaa actatgtaca
     2881 ggttttggga gtcaaacgac tgaattacat cggttgtggt ttgatatttt cagcgtggtt
     2941 ctcgctttat tccggtcaga actcctatgt gggaatcatc atcggaattt ttatcataga
     3001 tataggcatg caatgcatcc aattgagtaa tcagactacg attttctctc ttagcccgaa
     3061 ggcggccaac cgtatcaaca ccatttttat gacgacctat tttattggcg gttccatagg
     3121 tacacttctt gccggaatat tttggcactg gtttggatgg cagggagtag taggaacagg
     3181 tatcacactg gcaacctgtt cctttatgat aaatatcttt tcaaaaaaat aaatcaggaa
     3241 tccatatcgc ttagatgcaa ttccagcgcc ttgaccgaaa tataaatctc gcgcacagaa
     3301 atccccaaag aaataatgag cagcacaagc gccagtccaa aaatatatac ggatataagg
     3361 tagaactgta tatacattaa aaacatactg accacacaaa gcaacaaact tccgatacct
     3421 gtcacctgca tggcacgtgt cagataaaga cgcttgcgga gattagcaat ctgtgctgct
     3481 gtcacagccg aatgattctc acgatattgg tccttcaacg tacgcactaa ttgagcgtat
     3541 gaaagaaaac gattagtata tgccaacata atcagcgata tggcagaaaa taataaagca
     3601 ggagttgtta aatctatttc catttttata ggtatttcaa agttagaata ttgcaaagat
     3661 aaagtaaata tcccgatatt ctccttcctt tttacaatga aaggaatatc tttgcaataa
     3721 aaataattca aataaactaa tatgcaaacc ataaaattat acataaaaga ttggttggct
     3781 atccatcctt acatccaaca acaggctaca gacagatatt ttgtcgatct ggctaaccga
     3841 ttatactcca cttgtacgat aagagagatt cccgaatcca taaaaaagaa attatgtctt
     3901 tacaccgctg cctattttga agatgtcatt tcaggtttag gtctatggca agcattcatc
     3961 aaaaaacatc tggaactata tgatacgtca cttcctttct ataccatccg gccggattat
     4021 ataaaagatg agatcaatga agaagatatc cgcttcatca tttggaacac tttagagaag
     4081 gctccatata aacatccgta tatcaatccg atggacagga atatcgaaga aacctcgcat
     4141 tcatttttcc ggatattgga tgaagagtat gaaacggctc ccgccaatga cacgttacag
     4201 gatttcttta tggacttcaa aggaaaagag aacgcaaacc ataaactacg ctggctgttc
     4261 ggacatactt atctcacaga accatctgta caagaatata ttgcacaggt tacagaaacc
     4321 gacaaattca tcattccatg tggccccctt gccctgtttc ttcatgaatg gattgacctg
     4381 ctgaccaacg gagaaaccga atgttgggaa gagatagaag gactataccc tgccattccc
     4441 gaaatatcgg atgaaatgaa ggaaaggaac caccatacct atcaattgtt cacgcaaggc
     4501 acaaacggtg cccgtatcgt atatctggaa ggatataagg aactacaccg tttccttacc
     4561 caagtattac aatggccgga cgattccaat cacactttgc cccaaatgaa ggaacataag
     4621 gatttcatca tgatggtgaa ttccgaaaaa ggtattctac tggcgaaaga tatatgcaaa
     4681 tacatcagtg accctcttaa cccgatgtat gatgccgcaa cggctgccca agaggcattc
     4741 agcctgctta ctatcccgac caaatgccca ccggacctga tggaatatgt aataaacaac
     4801 cactatatcc ccgatgcaca attccccgaa tttggtgaaa gggaactggt tcaaaagaat
     4861 gcggacttta tagcccgcaa ctccttatta tattactaca ggggagatta gactctcccc
     4921 accgctactt cgttcaccaa agatctactt tcagcaaagt ctttcacatt ttgcagagta
     4981 gtatgagcaa tattcgtcat tgcttctttg gtaaagaatg cctgatgaga agtcacaatc
     5041 acattgttga aagacaaaag acgggctaaa gtgtcatcat caataatctt gtcggactta
     5101 tcttcataaa aataaggctc ttcttcctcg tatacatcca gaccggcata tcctaccttt
     5161 ttagtcttca gtccctctat caaggcattg gtgtgaatca actgcccacg ccccgtattg
     5221 ataatcatca ctccgtcttt cattttactg atggaataat cattaatcag atactttgtc
     5281 tgttctgtca aaggacaatg cagggagatg atatccgaac tatgataaag ttcatccaaa
     5341 gtacaataaa ccacctgatg ttcacgggca aaattgtaat cgggataaag atcatatgca
     5401 agaacattca taccgaatcc acgtaatatc tgaattaaaa tcttggcaat cttacccgta
     5461 ccgataattc cggcagtctt gccatgcata tcaaatccca taagcccgtg cagggagaaa
     5521 ttcccgtcac gtgtccgcat tgtagcacgg ggaatcttgc ggttgagtga taacatcaac
     5581 gccaccgtaa attcggcaac ggcataaggt gaataagccg gtacccgtac cactttcatc
     5641 ttacctgccg ttgccgctaa atccacatta ttataacctg cgcatcttaa agccagcagt
     5701 ttaacaccat tatccgccat tgcccggata acttcggcat cagccgtatc gtttacgaag
     5761 atacaaacca catccactcc tttggtcaac accacgttat tcatattcaa atggcctttg
     5821 taatacctga tatcaaagcc aaacttctca ttagcctccg taaacgagcg ttcgtcgtag
     5881 ggtttcgtgt cgtaaaaagc tattttataa gccataattg tttttccatt tatagttcat
     5941 ataaataaca aaaacacggc ccctactgtt cacatactga cttatagttt tttcagttcc
     6001 gtgtacaggc gctgtacagg aagccccatc acattgaagt aactacctga aataccacgg
     6061 acaccaatga aacctatcca ctcttgtata ccataagaac cagccttatc catcggcttg
     6121 taaacccgga tataataatc gatctcctca tcggacaatt ctgcaaacgt tacttctgtc
     6181 acagctgaaa aacttcgctg agccccgacg gtagtcagac aaactccggt tatcacctga
     6241 tgggtcttgc cggaaagctt ccacaacatt tgccgtgcat catcctcgtt atgaggcttg
     6301 cccatgacta caccatccaa ccatacaatg gtatcggcag taataatcaa ttcgtccgga
     6361 tgcatggtat tccggtaagc agccgccttt tcgcaagcta tatacaaagg gatttcctct
     6421 gctttcaatg tatccggata ggtttcctct atgccgggta gtgtttttac ttcatatttt
     6481 atacctaagc cggataacaa ttctttgcgg cgcggagaat tggaagcaag gattatttta
     6541 tatttttcta aattttccaa cataactttt ctttatttca ttaccacccg aaggcctttt
     6601 catgagccat ccattttcct tgagccttca agacctgttc caccacgtca cggccacatc
     6661 catatccccc gttacgatga gaaatataaa cagctgtttc ctttatctca ggtgccgcat
     6721 cagcaggaca acaaggcagc ccacacaaac gcatcacttc ataatcggga atatcatcgc
     6781 ccatatagag tatctcctca tcctgcaatc catatttttc cttcaaatgg gcatactccc
     6841 gggtcttcac cgcagcagcc agatagacat ctttgatacc cagcccctca taacgcttac
     6901 gcaccgcctc ggtatttcca ccggtaatga tggcaacatg cagcccgcat ttcacagcca
     6961 actgcaatgc atacccatcc ttgatattaa ccgtacgcat gggttcacca ttggggtgca
     7021 aataaatagt ttccgcactc aataccccat ctacatcaaa taccaatgcc tttattttct
     7081 ttaaatcata gtttatcata ccacttatga gttctttccc tctttatttg cctgaatgac
     7141 agacaaaggg agattatgaa tacttttact tatcttttcg tacaattcct gcaaagactc
     7201 ctcatccgcc aacatctcca aatgtttgct tattacgttt tcatcgtagc gtacagccgg
     7261 acctgtctgc gcctgtgtgg gagaaagttc atgtactttg ccggcagttt cgtctatcag
     7321 cggaagcatc acttcaaaag gaatcccctg cttttccagt atatgtgaac ttaatgcata
     7381 catatggttt gcaaaattac aagcaaagac tgccgccaga tgcaaatacc tacgttgccc
     7441 ggaagtcact tcatacactt taggactgag acgaactgcc accatacgca gcaattccac
     7501 ttctgccgga gcagatgctt ctataaaaaa aggtacagta ttgaaatcca cttcacgctg
     7561 cttgctaaaa gtctgcatag gataaagtac cccatagcgt tttaccaatc ccttccataa
     7621 atccatagac atactacccg ccgtatgtac aaacaaggcc tgctcccttc ctttcaccaa
     7681 tacaggagcc aattgtcgca aaactgcatc tttcagcgct acaatataca aatcggcatc
     7741 ccgacgtatc tcgtccggca caatagtgta gtctactgaa agtctggcag ccaatgcaga
     7801 agcagattcc tctgtacggc tgtatacctg caagataaga caccccgcct tttgtaaagc
     7861 aattcccaga tgggttgcca cattgccagc tcctatcaga actattttca tcatcgggtc
     7921 gaaactaaat ataaaataac tcccaccagc aacaaagccg ccggcaacaa ataagcagac
     7981 atctgtccca acaaagctat caccaaaccg atattcaata tcagccatat acccgtcaat
     8041 acaattccta ctgacttatc agccttgaac caaaggaaaa taacagctgc atacagtaac
     8101 agattgtctt tctgcataac ccatggcaac ccgtgtgaag caaatcctat aaacttatcg
     8161 atcagataaa gcatccccat cacaatgaga aacaccgcag aagctttata cgtatcctta
     8221 tgattgacag cagccacgtt tacttgcctc catatttatt aatgtgaatt ttctcccatt
     8281 gtaaatgctc ctcattaaaa ggcttgcgtt ccataccctt atgccctacc gctataatgg
     8341 aaaccacctg caactgcaac ggaatatcaa gcaacgtatg cacgtattca cccgagggca
     8401 tcccggtagc ggtaaaacgt tcacgcacct gtatccaaca acttcccaac cccaaatctt
     8461 ctgcctgcaa ctggatcatt atggaagcaa ttgacgcatc ttcaatccag acatcactag
     8521 ccaacggatc agccatcaca actacagcca tagcagcatc cgctaggaaa gccgccccca
     8581 tctccttaca atgggaaagt ttttccaaca tatccttatc atctaccaca ataaactgcc
     8641 agcaattact acgtttagaa gacggagcca tcaaagcagc cttcaacaaa gcaactacct
     8701 cttcctgtgt caactcttga tccgtgaact tacgcatgct gcgtctgttc tttattaagt
     8761 cactaaattg ttccataata taccctgtta atttattttt ctgcacaaat atacaactag
     8821 aatgtggatt gataaacaaa aaacaataaa tttgcaatta gagatgcctg tcagattaag
     8881 tacatatcgc aaaggaaatg ccattccccc tctgccggga acaaacattt tccattctac
     8941 cgagctgttt catgtctttg aaatgacccg gggatacgaa cctttgctta tcgtagccta
     9001 tataggaaac cgtcctgtag gcaaactgct ggcagtcatc cggaaaagtg tgcgcctgtt
     9061 cccccctgca atcatcaaac gatgcgaaat ttatggcaca ggcgagtatt ttgatgaaga
     9121 acagaataag gaagacctgt tcggggaaat attggaacat ctcaccaacg aagtattatg
     9181 caaatcgttc ctcatcgagt tccgcaactt ggaaaatccg ctattcggat acaaagcttt
     9241 cagaaagaac aactatttcg ccattaattg gctaagagta cgtaattcac tgcacagtaa
     9301 agctccttac gaacggctga gcatgtctcg cagaagacaa ataaacaaag ctctgagaaa
     9361 tggtgccatc atggaaatag ccgacaatga gaaagatata caagatttct cacgaatgtt
     9421 gaaaaaagcc tattcctcac agataagaaa acatttcccg gacatcggct ttttccggtt
     9481 attagcatgg cagaacccgg aaaaagaatt agccaaagtg tttcttgtga aatataaagg
     9541 caaaatcatc ggtggttcta tctgtctttt ctcaaaagaa agtgcctacc tgtggttctc
     9601 aggaggtatg cggaaaacct atgcttttct ttaccccggt attctgtccg tatgggcacc
     9661 tattacctat gcttacgaaa aaggatatgc acatttggaa ttcatggatg caggattacc
     9721 gttcaaaaag cacggttaca gggactttat actccgcttt ggcggcaagc agagcagtac
     9781 acgccgctgg ttccgcttca gttggaagtg gctgaacaaa ctcttgtgca aattctatat
     9841 ttaactcatt tttgtctttt tgtctaaagt gttgtgaagc atcttgcaaa taagaaataa
     9901 aattgaagaa atatttcttt atttaactcg aaattacttt ctttgtgcag ttttatctga
     9961 aaacttgagt ataaaaccaa actattaaaa ttataagatc atgaaaatct cacacattga
    10021 acacctgggc attgccgtaa agagcattga agaggccctg ccgtattatg aaaacgtatt
    10081 aggtctgaaa tgctacaata tcgaaacagt agaggatcag aaagttaaaa ccgcttttct
    10141 gaaagtaggt gatgttaaaa tagaactgct ggaacctaca agccccgaaa gcactatcgc
    10201 aaagttcatt gaaaaaaata atggcaacgg tggtatgcat catttggctt ttgcagtgga
    10261 agatggtgtg gcaaatgcgt tagccgaagc tgaaaccacc ggcatccgtc tcattgacaa
    10321 agctccgcgt aaaggtgccg aaggtttgca aattgctttt ttacatccca aatcaacttt
    10381 gggcgtcctg accgagcttt gcgaaaaacc ataaaacacg agatctgact attcacgatt
    10441 gaagtcagta tatttagtct ggttcaagcg taaatagaat tattttttaa tcgtaaattg
    10501 taaaatcata agtaaaatga gcaatcaact tgaaaaaata aaagagctta tcgaacgccg
    10561 ggctacagca cgcatgggtg gaggtgataa agcaattgca aaacagcatg ataaaggaaa
    10621 atatacagcc cgcgaacgca tagccatgct gctggatgag ggcagtttcg aagaaatgga
    10681 tatgtttgtg gaacacagat gcaccaattt cggcatggag aaaaaacatt atccgggcga
    10741 cggtgtagta acaggttgtg gtaccataga aggacgttta gtttacatct ttgcacagga
    10801 tttcactgtt tctgccggtt ctctttcaga aacaatgtct ctgaaaatat gcaaagtaat
    10861 ggatcaagct atgaaaatgg gtgctccctg tatcggtatc aacgactcgg gtggcgcacg
    10921 tattcaagaa ggtatcaatg cattggccgg ttatgctgaa attttccaac gcaatattct
    10981 tgcttcaggt gttattccgc agatctcagg tattttcggt ccttgtgcag gcggagctgt
    11041 ttactctcct gctctgacag acttcacctt gatgatggaa ggcacatcat atatgttcct
    11101 taccggaccg aaagtggtaa agactgttac aggtgaagat gtaagccagg aaaacttagg
    11161 tggtgcaagc gttcattcaa ccaaatccgg tgttactcat tttacagcca agacggaaga
    11221 agaagggtta gccatgatcc gcaaattgtt aagctatatt cctcagaaca atctggaaga
    11281 agctccctat gtagactgta ccgatcctat cgaccgtctg gaagactctt tgaacgaaat
    11341 tatccccgac agccccaaca aaccatacga tatgtatgag gtgatcagcg ccatcgtaga
    11401 taatggtgag tttttggaag tccaacctca ctacgctaaa aatatcatca ttggtttcgc
    11461 acgtttcaac ggccagtctg taggtattgt tgccaaccag cccaaatacc tggcgggtgt
    11521 gcttgacagc aatgcgtcac gcaaaggtgc tcgttttgta cgtttctgcg acgctttcaa
    11581 tatacctctt gtttcattgg tagatgttcc gggattcctt ccgggtacag gacaagaata
    11641 caacggtgta atcctccacg gtgccaagtt gctgtatgct tacggcgaag cgactgtacc
    11701 caaagtgaca attaccctgc gtaaatcata cggcggatct cacattgtaa tgagctgtaa
    11761 acaacttcgc ggtgatatga attatgcatg gcctactgcc gaaatcgccg ttatgggtgg
    11821 tgcaggtgca gtagaagtat tatacgcacg cgaagccaaa gaacaggaaa atcctgccgc
    11881 attcctagcc gaaaaagaag ctgaatacac caagctgttc gccaatcctt acaatgctgc
    11941 caaatatggt tacattgatg atgtgattga accgcgtaat acccgtttcc gcatcatccg
    12001 tgcattgcaa cagttgcaga ctaagaaatt aaccaatccg gctaagaagc atggtaatat
    12061 tcctctttaa ttaaaaatta aaaactgaga attgaacatg aagaaattaa atataggaat
    12121 attcctttct ttgctgctga tggtggggtt atgttcttgt ggagaacaga aatcgaacac
    12181 caagctggta ctgaatgaag tgctgattga aaatgaaagc aatttccagg atgactacgg
    12241 agtacacagc gcatggattg aaatattcaa cagatcattt ggtagcgcag accttgccgg
    12301 ttgtttactg aaggtgagca gccagcctgg agatactgct acttatttta tccctaaagg
    12361 tgatgtattg actttggtca aacctcgcca gcacgcttta ttctgggcag acggcgaacc
    12421 caaccgcggt actttccaca ctaatttcac actgaatgcc gcaaccgaca attggattgg
    12481 attgtatgat tcaggcaaaa aattattgga tcagattatt gttccggcag gcacattgca
    12541 agcaaaccaa tcatacgcac gtgtcagcga cgcagcaaat gaatgggagg tgaaaggttc
    12601 cagcgcagac aaatatgtga ctccgagcac caataacaag actatcaaca gtcatgcaaa
    12661 gatggaaaaa ttcgaagaac acgacggtag tggtatcggt atggccatct ctgctatgag
    12721 cgttgtattc tgcggtcttc ttttactttt cattctcttc aaatgtgtag gtaagatttc
    12781 tgtaaacctg agcaagcgca atgccatgaa ggtaaaaggt attaccgaca agcaagaagc
    12841 caaagaaaag aaattgggtg aagctccggg cgaagtattc gccgctatcg ccatggccat
    12901 gcatgaaatg caaagcgatg tacatgacgt ggaagaaacc gttcttacca ttacccgtgt
    12961 aaaacgtagt tattcaccgt ggagttccaa gatttatacc ttgcgtgaaa ctccccacaa
    13021 aaagtaagtc accaataaaa agataaaatg atgaaagaat ataaatataa gatcaacggt
    13081 aacgtataca aagttgccat tggagatata gaagacaata tcgctcatgt tgaagtgaac
    13141 ggtactcctt acaaagtgga aatggaaaaa gctccgaaag ctgtagtgaa accggtagtt
    13201 cgtcctgtat caaccagccc tgctccggca ccagctacag tagtaaagcc tgctgcaact
    13261 tctacaggta aatcgggcgt taaatctccg ttgccggggg taatccttga tatcaaggta
    13321 aatgtgggtg ataccgtaaa aaaggggcaa accatcatta tccttgaagc tatgaagatg
    13381 gaaaataaca tcaatgcaga caaagacggc aagatcaccg caatcaatgt aagtaaagga
    13441 gaatccgttc tcgaaggtac tgaccttgta attattgaat aatatgggag aatttatcaa
    13501 ctttttaggg aataacctag ctgacttttg gacatatacg ggttttgcca atgctactgt
    13561 tggtcatatc gtaatgatcc tgataggttt attcttcata taccttgccg tggccaagga
    13621 atttgagccg atgttgctca ttcctatcgg tttcggtatc ttgatcggta atattccttt
    13681 caacatggaa gccggactga aagtcggcat ctatgaggaa ggttctgttc ttaatatttt
    13741 atatcaagga gttacctccg gatggtatcc accacttatc tttttaggta tcggtgcaat
    13801 gacggatttc tcggcattga tttcaaatcc taaactgatg ttgattggtg ctgccgcaca
    13861 gtttggtatt ttcggtgcat acatgattgc attggcaatg ggctttgatc cgatgcaggc
    13921 tggtgctatc ggcatcatcg gtggtgcgga cggtccgaca gcaatcttcc tttcatccaa
    13981 actggcgcct aacctgatgg gagctattgc ggtatctgcc tattcataca tggcattggt
    14041 accggttatc cagccgccta tcatgcgtct gctcactacc aagcacgaac gtttgatccg
    14101 tatgaaacca ccacgcgtcg tttctcatac agaaaaagta atgttcccta tcattggttt
    14161 gttgcttact tgttttctgg ttccgtcggg tctgcctcta ttgggtatgc ttttctttgg
    14221 taacttattg aaagaaagcg gtgtaacccg tcgcttggca gaaactgccc gcggtccgct
    14281 gattgatacc attaccatct tattaggatt gacagtaggt gcttccacgc aagcttcaga
    14341 attccttacc attgattcga ttttgatttt cgcgctgggt gcattgtcat tcatcattgc
    14401 taccgcttcg ggagttatct tcgtaaagat attcaacttg gtattaggta aggataacaa
    14461 aatcaatccg cttatcggta atgccggtgt atctgctgtt cctgactcgg cacgtatctc
    14521 tcaggttatc ggtctggaat atgatcctac caactacttg ctgatgcatg ccatgggtcc
    14581 caacgtagcc ggtgtaatcg gttctgccgt agctgccggt attttacttg ggttcttgat
    14641 gtaattcatt gaacaacaat aaataaaagg aggtgtgtcg taatgcacga tgcacctctt
    14701 tttttgttca tcactataca aatctgttca ctttctttaa gctgcgatct tttgaagatt
    14761 tctttgattt atgtgttccc agcatctaaa aacagcagtt gtaagctcat aaaacagtct
    14821 aatcagccag ttcataccct tttttgtcag ttttgcacac atctttttta tattgaaggc
    14881 aatggctagg aaggcaaagt ccatgaagac cttgtccttt ccaaaatgtc ggaaacgttt
    14941 gtagttcata ttgtttttaa tttgtccgaa cacggcttcc ggttctatgc atctctgccc
    15001 tctgtgtttc agtcctttct cagagcagag cagttctttg gctctccgct tgtattgtct
    15061 aagcctatga ttcagttcta tcgtcctgtt tccttttgct ttaaaacagc ggcatcgcag
    15121 gggacagcct tcacacctga cagctctgta ccgtgcattt tcgttgacat atccggatgc
    15181 ggttttcaca ttcctggtgc ctatcctccg catcctttgc cccatagggc agatgcagaa
    15241 gtcatgttct tcattgtagt agaagttttc ggccttgaac gggtccggtt tgaatctcgg
    15301 ccgctgctcc atgtggaagt agttgtactt tacgtaggct tccatgccgt tttcggacat
    15361 gaagcggtaa ttctcttcgg agccatagcc ggaatcagca accaccgtat gggccatccg
    15421 gtcatacctg tttgaaaaag attgcaggaa aggaatcagg gtcagtgtat ccgtagggtt
    15481 cgggaagagt gcaaaatcgg tgatgaactg attttcggtg ccgatttgaa ggttgtaacc
    15541 gggcttcgtc tgtccgttgc gcatggcatc ctccttcatt ctcatgaaag tagcgtcatt
    15601 gtccgttttg gaataggaat tcctgtcctg cagcgtgtcc agacggttgt cgtattcctg
    15661 tagcttgtcc ctgtgctctt ccaact
//
