LOCUS       c00002_gnlPro..        13727 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CEBGIEOJ_2.
ACCESSION   c00002_gnlPro..
VERSION     c00002_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:05:04
            Original ID  :: gnl|Prokka|CEBGIEOJ_2
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 51494
            Orig. end    :: 65221
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13727
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[61494:64984]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13490
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13727
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13727
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(338..928)
                     /locus_tag="ctg2_60"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREDGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
     CDS             1168..2778
                     /locus_tag="ctg2_61"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             3021..3359
                     /locus_tag="ctg2_62"
                     /transl_table=11
                     /translation="LAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDAL
                     IEKMKKRMEMLDNRCRQEGKRPFEARYYGSAALKDILENSDEFSGLVEPDEDGAPPNAI
                     RENEEAGQ"
     CDS             3461..4234
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_63"
                     /sec_met_domain="adh_short_C2 (E-value: 9.8e-75, bitscore:
                     243.3, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILI
                     SRSPSSCGGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFLQIDILVNNAGIT
                     RDSLMLRMKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQA
                     NYAASKAGLIGFTKSLALEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKE
                     QGSVEDIAALTAFLASDDARYITGQVIACDGGMTM"
     CDS             4258..5463
                     /locus_tag="ctg2_64"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYAAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSAGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPTKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             complement(5507..5692)
                     /locus_tag="ctg2_65"
                     /transl_table=11
                     /translation="MTDVASTMFPDDAAAVDGDCILLRDEGRTDAHDMEQVMFIAAGDE
                     IVSERFSRDMFRFGMV"
     CDS             5730..6167
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_66"
                     /sec_met_domain="Acetyltransf_1 (E-value: 3.2e-08,
                     bitscore: 26.1, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPIAVLPEYQRRGIGRRMIGYTRNRAREMGFRAIFLYGDPDYSS
                     HCGFVPAETLGIRTADNRYAAALQVCALQRGSLSGLKGRYVEAAVYHMDEKRAAEFDRH
                     FPVKKKLSGIASQKRFQQIAAMRRKPDTAPCPRKSRTFRRA"
     CDS             complement(6269..7108)
                     /locus_tag="ctg2_67"
                     /transl_table=11
                     /translation="MIDLASFSLLDGFQIRLGNSKFATSCHPKGIINMKKTLTLLIAMG
                     SFAVSSEAATVFNYYTPGTDNYNSTIHGFYLSLGSSSLAPSDSSSPSSLSGEIRLDSFT
                     LRGAANNLGANVTYGFLVLNGSDNSVIGWSTNTGTTAAGINLTFSFSSLDGSPLLLDAA
                     LTYRFLAVSQSVMGLMQDTSKTYLYAAGGTAAPTANTEGDTVTISGGLTAPGIRGHYDA
                     EGTPGDSVVITGANGTNTFSLLSPIFTEIRGEMVPEPATVSLGLLGLAALMMRRRRA"
     CDS             7184..7273
                     /locus_tag="ctg2_68"
                     /transl_table=11
                     /translation="MNYKHNILTLNIFNCLRIPNSLFKHKYIH"
     CDS             7304..8011
                     /locus_tag="ctg2_69"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATSLLDSSIVGYSDFASQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLSKINTPDAYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYNGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQINQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             8443..8676
                     /locus_tag="ctg2_70"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLCRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9525)
                     /locus_tag="ctg2_71"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg2_72"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_73"
                     /sec_met_domain="SucD_FumR (E-value: 3.1e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_74"
                     /sec_met_domain="FAD_binding_2 (E-value: 5e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.4e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12723..13490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_75"
                     /sec_met_domain="Fer2_3 (E-value: 2.7e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 9e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.1e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
ORIGIN
        1 tgaagaacat cgctatcctc gccatcgccg gcgccgcttg cctggtcgct tcttgctccc
       61 agcagcagca gcaacagcaa accaccgctc ctgctcccgc tccggttgtg caggccaagg
      121 gcaagtaagt ttgcagcggg gttttgccct gcaacactag caaattatcc aattaatccg
      181 cactcggtgt acgcactgag tgcgttttta tttgccctga gtccggattc cctccgccat
      241 ttgccgattc gccgggattt tccttaaaaa cggcggatac cgcaaaccgc cgcggcgcag
      301 caccgtgtgc cggttcttgc cggatcaggc ttccccttta ttcagcggcc gccttcgcct
      361 cattctgctg atcggactga aatatccgct gaaccagcat ggggcgtttc ctggcccacc
      421 cgggccagac caggtgatgt tccatgccgt aggaatggcc ctccggaaag gccttggaaa
      481 caaatggttc ccgccagtcc tcctcccatt tgccgtcttc ccggtccttc tgggtcagcg
      541 tcaccagatg cccgcagttc ttccaggcat ccagaacaat ggagccctgc aatcccttcc
      601 ccgcggcatt gacatacacg caactgtgct ccctgcccgt tccacggtct cgaatcgtca
      661 gccctatgcg gaaatacttc acggggcggc ggcgcaggtc ccggtacaaa tcctgctgga
      721 cctgccagca cagccccctg tcgcgcaggt tggaattgac cagaatattg ttcagccagc
      781 caaacagcac agtcctgttg tcccgggcaa tcgctgcgga ctggaccacg gccgtgtccg
      841 ccagccacct ggcctccgct ccggcagcgg gaagagaggc ctgatccggc ggcagcagcg
      901 ccaggaaggc attagccagc ccggacattt gctgctgcac gtaaggttgt tgtatataat
      961 cctccgccgg aggagtacag caggaactcc atccgcacaa aagggcggca gcaagcaaaa
     1021 gcctgaatgt ctgcgtggtc ggcatggcgc gccaaggcta gcagactacg cgtaaaaatc
     1081 cagtaaagct ttcaaaaatg cctgcctccg ccctgacggc tcttgccttc ccctttccat
     1141 cccggtagaa tacatcctct cttcaccatg ctgacgatca aaaatctcac aaaatcccac
     1201 gccggacgga ccttgttcag ggaaacggaa atgaccatta actgggggga acgggtggct
     1261 ctggtcggcc ccaacggagc aggcaaatcc accctgttcc gcatgattct gggagaagac
     1321 acgccggacg aaggctccat cagcatggat gaatacgcca tcgtgggcta tcttccccag
     1381 gaagccagcg aaccgaagga tgaaaccgtc ctggaaatcg ccctgggcat cacgccggaa
     1441 atggaacagg ccatccacac catccggacg gcggaaaacg ccaacaaaac ggatacgccg
     1501 gaatacgcgg aagccattga caccttcaac gccgccaacg gttaccagct ggagcccaaa
     1561 gccaagaaaa ttctcaaagg gctggccttt cgggaaagcg acttccaccg ccccgcccgg
     1621 gaaatgtccg gcggctggat catgcgcgcg tacctggcca agctccttgt cctggagccg
     1681 gacctcctga tgctggacga acctaccaac cacctggacc tcctgtccct gctgtggctc
     1741 cagcgatacc tgaaaaacta ccccggagcc atcctgatga tttcccacga ccgggatttc
     1801 atggatgagc tggtggaaag cgtgtacgac atcgacaacg aagaactggt ggaataccga
     1861 ggcaattact cggacttcct ccaacaaaag gacgtgcgct tcgagcagct tcaggcggcc
     1921 taccgcaacc agcagaagga aatagcgcac attcaggaat ttattgaccg tttccgctcc
     1981 atcaattcca aagccgggca agtccagagc cgcatcaagc agctggaaaa gatgaaaatc
     2041 attcaaaaac cggtagcccg caggaaggta tttaaattca acttccccca gcctccgcgc
     2101 agcacccaga aagtcattga gctggaaaaa gtctgccaat cctatggcga ccgcagggtt
     2161 tatgaaaacc tggacctgct ggtggaacgc ggggagcgca ctgttcttgt aggtccgaac
     2221 ggcgcgggca aatccactct tctcaaaatc ctggcgggca tcatccccat tgactccgga
     2281 caacgcactc ccggtaccac gacgcgcatc ggctacttct cccaggcgcg aacggaaaac
     2341 ctgaatccgg aaaataccgt gctggaggaa atcatgaaat gcagcgctga aatccgggag
     2401 gaagaagcgc gttccatcct gggttccttc ctgttccgga ggctggatgt ggaaaaacgc
     2461 gtcagcgttc tttccggcgg ggaaaaatcg cggctcagct tggtcaaatt cctagtggat
     2521 ccgcccaacc tcctgctgat ggacgagccg accacccacc tggacctttt gtccgtagaa
     2581 gccctggtgc aggctctgaa gcattatgaa ggaacactgg tcttcatctc ccacgatgtg
     2641 cacttcatcc gttccctggc acaaaaaacc ctgcatgtga accgggggac catcaccgcc
     2701 tacgcaggcg gatatgacta ctatctggaa aagtcaggca ttctggacga tgaaaaaggc
     2761 ggcatcacgg cggaataagg ctcttttttc agtttcccct ttttccttgc cgtggatttc
     2821 atcctgcctc aaaagaacag gatgaaggct tttcttgttc ctctcttata ttctgcgctt
     2881 ctgtccggag cctctcttgc atttggtgaa acggccgccg gaacggcttc cccacagcag
     2941 cggctccggc ggaaaaaatt ccttccgcgg aatccctgat caaccaggcc ttttcctttg
     3001 ccatcaatat ccagcagacg ttggcaggcg ttcaggacaa ggaaagcgcg gacaacgccg
     3061 tcaaaacgct gcaggacatt cagaaggaca tccggcattt cctccagctt caggataaat
     3121 tgaacgatgc ggaaaaggag aaagaagacg ccttgataga aaaaatgaaa aaacgaatgg
     3181 aaatgctgga caaccgctgc aggcaggaag gcaaacgccc gtttgaggcc cgttattacg
     3241 gttccgccgc cttaaaggac attttggaaa attcggatga attcagcggc ctggtagaac
     3301 cggatgaaga cggggcgccc cccaatgcaa tccgggaaaa tgaagaggcc ggacagtagc
     3361 ctccccctca ccccgtttct cccccttttt tcattcccgg cccgcccttt ccccatatgg
     3421 ggtcctgcgc ggccaggtcc atttcaagct tgccggaacc gtgaaaaacg ggtttactgt
     3481 gggcagcatg caaaagttag caggtaaaac agccatcgtt accggcgcgg gtcgcggaat
     3541 cggcaatgcc gtcgcgcgcc gcttcgcttc ggaaggagcc agggtcatcc tgatcagccg
     3601 cagtccatcc agctgcgggg gagccgcaga agaaatcaac aaggaatttc cggattcctg
     3661 caaggcctac ccctgcgacg tagcggatta cgcggccgtt caggaaacca tggccgccat
     3721 tttgaaagac ttcctgcaga ttgacatcct ggtgaacaac gccggcatca cgcgggactc
     3781 cctgatgctc cgcatgaagg aggaagactg ggatgccgtt ctggacacca acctgaaaag
     3841 cgcgttcaat acggtcaagg ccctccagcg tgttctcatg aaatccccgg ccgggcgcat
     3901 catcaacatg agctccgtca tcggtctcgt cggcaacatc ggccaggcca attacgccgc
     3961 ttccaaggcg ggcctcatcg gcttcaccaa atcactggcc ctggaattcg ctccgcgcaa
     4021 agtcacgtgc aacgccattg ctcccggctt catctccacg gaaatgtcca atgccattcc
     4081 cgacaatctc aaggaagaaa tcgtcaagaa aatacctttg aaagaacaag gttccgtgga
     4141 agatatcgcc gccctgacgg ccttccttgc ctctgacgat gcccgttaca tcaccgggca
     4201 ggtcattgcc tgcgacggag gcatgacgat gtagggcatt ccggttttca ccattccatg
     4261 cgcggcattt tccttgtttc ctgctttctg ggaggaagcg ccctgctggc cgggtgccgg
     4321 gaagaaaata attccccccg cccggccacg gaagatgccg cgcgcattac cagcgcacgc
     4381 cagtggggag aaagccgatc cgcgctgcaa aaacgggaac tggaccgcgc tgccggtcct
     4441 gcccttccca ttccggatga cctgccgtcc cgggagctgg tcggcacgac gcgccaaatc
     4501 catcagctca ttgaagcttc cggaaatccg gcacgttttg aatcctacac ggaaacggtt
     4561 cccgcggcgg gagcttccct gcgcatggtc gccataccgg gaggaacgtt cctcatgggg
     4621 agtcccgcgg aagagccgca ccggaaaccg gacgaaggtc cgcagcataa agtgagcatc
     4681 tctcccttct ggatctcgga aacggaaatc ccctgggaac tttatacggc cttcatggaa
     4741 aacgggcgtc cgcgcgccaa ggacggccag cttctggagg aacagccgga tgacgaactg
     4801 tgggactccg tcacgcagcc taccgccccc tacgccgcca tgaacctggg catgggccac
     4861 ggctatgaac acggcctgcc cgccatctcc atgtcccacc acgccgccag caaattctgc
     4921 gaatggctga gcgcccagac cgggcattac taccgcctgc ccacggaggc ggaatgggaa
     4981 tacgcctgcc gggccggttc cgccggcgcc tattcttacg gaaacgggga agcctctctg
     5041 gaccagtacg cctggtactg gaacaattcc aatgaccgct accagaaaac aggctctaaa
     5101 aaaccaaata agtggggact ccgggacatg cacggaaatg tggcggaatg ggttttggac
     5161 tcttacgttc cggatgccta cggcaaacgg agcggcttgc ccacgaaaga ccccctggtc
     5221 atcatccccg gcgcccctca catcgttcgc ggcggttcgt gggaagacga cccggacagc
     5281 ctgagaagcg ctgcgcgccg cgccagcacc cccgcctgga accgtcagga tcctcaaaac
     5341 cctaaaagca tctggtacct gacggacgga ggcatgatcg ggttccgcgt ggtgcgcccc
     5401 atgaacattc cggacattat gacgatgcac cgcctctgga atttctccaa gggggagccg
     5461 taaagaacaa tctttcatga ccattgcatt aagaacggaa caatcctcag accatgccga
     5521 aacggaacat gtcacgagag aagcgttctg aaactatttc gtccccggct gcaatgaaca
     5581 ttacctgctc catatcatgc gcgtcagtcc ttccttcatc ccggagcagg atgcagtcgc
     5641 catccacggc agccgcatcg tcgggaaaca tcgttgatgc aacgtccgtc atcagggcag
     5701 acgatggaaa agaatatgaa gtgctgggca tggggcccat tgccgttctt ccggaatacc
     5761 agcgccgggg aataggacgg cggatgatcg gctacaccag gaaccgggcg cgtgaaatgg
     5821 gcttccgtgc cattttcctg tacggcgacc cggactactc ttcacactgt ggattcgttc
     5881 ccgcggaaac gctgggcatc agaacggcgg ataataggta tgcggcggcc ctccaggtct
     5941 gtgcgctgca aaggggttcc ctatccggcc tgaaaggccg ctatgtggaa gctgccgtgt
     6001 accatatgga cgaaaagcgc gctgccgaat ttgaccggca ttttccggta aagaaaaagc
     6061 tttccggtat tgcgtctcaa aaacgtttcc agcaaattgc cgccatgcgg agaaaaccgg
     6121 atacggcccc ctgcccccgg aaatcccgta ccttccggag ggcatgaatc ccgcatgcgg
     6181 atgagtaatt cttcctctct ggatataaaa aacaagagct gttccgcaag aacagctctc
     6241 atccgccgat ttttcgccat caggaagctc aagccctgcg gcggcgcatc atcagcgcgg
     6301 ccagtcccag caggcccagg gaaaccgtgg ctggttccgg caccatttcc cctcggattt
     6361 ccgtgaaaat cggagataat aagctgaaag tattggttcc gttggctccc gtaataacaa
     6421 cagaatcacc aggcgttccc tcggcgtcat aatggccgcg gatgccggga gcagtcaatc
     6481 cgccgctgat cgttacggta tctccttccg tgttagcagt aggggcggct gtcccccccg
     6541 cagcatataa atacgtttta gacgtatcct gcatcaagcc catcacggac tggctcacgg
     6601 ccaggaagcg gtatgtcaat gccgcgtcaa gaagcagggg agaaccatcc agggaagaaa
     6661 aactgaacgt cagattaatc cctgctgcag tagttcccgt attggtgctc cagccgatga
     6721 ccgaattgtc ggagccattc agcaccagga agccgtaagt gacattagcg cccaaattgt
     6781 tggcggctcc gcgcagcgta aaactgtcca gtctgatctc tccggacagg gaggagggag
     6841 aagaggaatc ggaaggagcc agggaagaag accccaggct aagataaaac ccatggatgg
     6901 tactattgta attatccgta ccgggagtgt aataattaaa aacggtcgct gcctccgagg
     6961 aaacagcaaa gcttcccatc gcgattaaaa gtgtcagtgt tttcttcata tttattattc
     7021 cttttggatg gcaacttgta gcgaatttgg aattccccaa tcggatttgg aatccgtcaa
     7081 gtaatgaaaa agaggccaaa tcaatcatga aaccaatgaa taacaaagac tgacccgtca
     7141 tcttgacaaa aggaccagag atattaaaaa atcattattt tcaatgaatt ataaacacaa
     7201 tatactaact cttaatattt ttaattgctt gcggattcca aattcgttat tcaagcacaa
     7261 gtacatacat tgaatcttgc atcattttat taagatactg accatgaata aattattatc
     7321 caccctgatt ctttcggccg gcatgagcct aagcgctacc gcggctacct ctctgctgga
     7381 tagctccatc gtgggatatt cggactttgc ctcccaaacg gcggatttcg gcaccctgaa
     7441 agattccgtt tccatcacgt ctgacgacag caatctgacg ttatccggga taaccttcaa
     7501 cggatacggt gccaacaacc gcgacgttat gtctgtgacg atggttcttg acctgtccaa
     7561 aatcaacact ccggacgcct ataccgctct gtttaacgcc aaaaacagca gtgtaagctg
     7621 gggcgtgggc ctgaacacgg accggaaact ccagggatta tggaacaaca cctcatacaa
     7681 cgggcccgtc gttgacaccc cgctgggcac ggaaggttcc ctgaccattt ccgtagtcac
     7741 cggagatctt ggcacccgca tctattttgg cgacagcgct acgtactatt ccaacagcgg
     7801 cctgaaattc ggcaaccagc aaattaatca gattctcatg gacgcaggac tggctgaatc
     7861 catcgaacag ctctacatcc acgactccct cctttcccag gaacaagttg gtcaactgat
     7921 gagtgaaatc gccagcatcc cggaacccgc cacggcttcc ctgggcctgc tgggactggc
     7981 cgcgctgatg atgcgccgcc gcagggcata agcctgtacc gtccgcctcc ctatattcaa
     8041 aggccggctc acaaaatcgt gagccggcct tttccttatc cgttcaaaca tctgccggaa
     8101 aaaacagggg ggaagaagct tccatttgct gcggtaccct cacggccagc acttgacggg
     8161 gaaatggcat tcaggctccc ccgggagggt catttcaaga gcttccgacc ccgccccact
     8221 tccgtacacg cccctttttc ccatgccggg acagccggaa ccggagcatg caaagcccgg
     8281 cttccctcag catccggaac agcccatcct ttcagcaatc catttccccg cacggtccgg
     8341 atcgctgcgg tttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc tgagcttgaa cctttatccc ccgttcccgt ccatgaatct tcaaaaacag
     8461 cagctgctac tgcgcctgtg ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctgggc cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtaccctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc aggagaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgcagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccgcc gcccgcttgg gattcagctt
     8941 gctggtggga taaagggtca gcccggccca gtaaccggcc tccttcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccaacacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggcgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagcc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agtttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattttta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtc atccctgtag
     9601 gaaagggctt ccagaatggc ccggacacgt ccggggccgg atgcggacaa gaggggaaga
     9661 acatccatca gggcatggta acggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcact
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa actgataaac agcaacctct ttccccggct
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatca aggcgacgct
    10321 ctcctcccgc tacatgatct ataccggcct gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct tcatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaacgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctgc gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 gtacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtgcttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagtcc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcagccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttccgcgc ccgtgaagcc aatgtctacc gtctggcgga
    11101 agtctcctcc aacatcattg accagtgtgt ggcccagggc gttcccttcg gccgtgaata
    11161 cggcggcctg ctggacaacc gctccttcgg cggcgcccag ctcaagcgaa ccttctacgc
    11221 acgcggacag acgggccagc agctcctgct gggtgcctac caggccctgg aaaaggaagt
    11281 ggccaaggga cacattgaaa tgttctcgcg ccatgaaatg atggatctgg tgctggtgga
    11341 cggcgaagcc aagggcatcg tcacccgcaa tctggttacc ggcgaaatca aatcctacgc
    11401 aggggatacc gtcctgctct gcacgggcgg ctacggcaac gtgttcttcc tgtccaccaa
    11461 cgcgatgggt tgcaacgtca ctgccgccta caaagcctac aagcgtggtg ccttcttcgc
    11521 caacccctgc ttcacgcaaa tccaccccac ctgcattccg gtcaaaggcg actaccagtc
    11581 caaactgacg ctgatgtcgg aatccctccg caacagcggc cgcatctggg tgcccaagtc
    11641 ccgtgaaacc gcagaaaaaa tccgtaagaa ggaaatcaag ccttccgatg ttcccgaaga
    11701 agaacgggac tactacctgg aacgcaagta tccctccttc ggcaacctgg ctccgcgcga
    11761 catttcctcc cgcgccgcca aggaagcctg cgacgacggc cgcggcgtgg ccgtcaccgg
    11821 caagggcgtc ttcctggatt ttgcggatga aatcaagcgc atgggccgcg aatggattga
    11881 cggccaatac ggcaatctgt ttgacatgta cgaagaaatc acggacgacg acccccatga
    11941 aacgcccatg atgatctacc ccgcctccca ctacaccatg ggcggcctgt gggtggacta
    12001 caacctcatg tccaacgtga aggggctgca cgtcctcggt gaagccaact tctccgacca
    12061 cggcgccaac cgcctgggag cctccgccct gatgcagggc ctgtctgacg gctacttcgt
    12121 cattcccgcc acgctgcccg cttacctgac gaccaccaag cccggtgccg tcaccaccgc
    12181 cgccccggaa ttcaaggctg cggaagacga agtgaaggaa cgcatcaaca agctcctgaa
    12241 tgtgaagggc accaagacgg tggactcctt ccaccgggaa ctgggcctca tcatgtggga
    12301 agactgcggc atggcccgca cggaagaaag cctgacccac gccattgaac gcattcccca
    12361 gctccgcaag gaattctggg aaaacgtgcg cgtaaccggc acggcggacg gcatcaacgc
    12421 ggaactggaa aaagcctgcc gcgtggccga cttcctggaa ttcgcccagc tgctctgcta
    12481 tgacgccctg aaccgccagg aatcctgcgg cgcccacttc cgcgtggaat accagctgcc
    12541 ggacggcgaa gccaagcgca acgacgatga atacgcctat gtagccgcct gggaatacac
    12601 tggcgtggac agcctgcctg ttctccacaa ggaaccgctg accttcgaga acgtgcacct
    12661 tgccatccgc agctacaagt aaagatagcc aatacattaa cactcaaaag aaagattata
    12721 acatggctaa aacactcaat ctcactctca aggtctggcg ccaggaaaac cgggaagcca
    12781 agggccgcat tgagacctat gccgccaagg acattccggt ggacgcctcc ttcctggaaa
    12841 tgctggacat cgtcaatgaa ggcctggtca aggaaggcaa ggaacccatc cattttgacc
    12901 acgactgccg ggaaggcatc tgcggcatgt gctccctgac catcaacggc attccccacg
    12961 ggccggaacg ccaggtgacc acttgccagc ttcacatgcg caagttcaag gacggcgata
    13021 ccgtctggat tgaacccttc cgcgcgaagg ctttcccaat cctgcgggac ctgatggtgg
    13081 accgctccgc cctggaccgc atcatcgccg ccggaggcta tattgacgtg cgtaccggtt
    13141 ccgcgccgaa cgccaacaac atcgccgtgg aaaaagtgaa ggcggacgcc gcctttgacg
    13201 cggccgcctg catcggctgc ggcgcctgcg tggcctcctg taaaaacgcc tccgccatgc
    13261 tgttcacctc cgccaagatc gcccatctca atctgctgcc gcagggccag ccggaacgtt
    13321 ccaagcgcgt cctggccatg atgaagcaga tggaagcgga aggcttcggc aactgcacga
    13381 accagtatga atgtgaagct gcctgcccga aaggcatcag cgtggacaac atcgcccgcc
    13441 tcaaccgcga cttcatgcga gccaacgcca aggaaggcct ctgtttctaa agaagattcc
    13501 ttcttaagac gctctgtaaa aactcccggc ggcatcggct gtcgggagtt tttttcatta
    13561 tcaggtttcc ttgaaccagg aataaaatat cagacagttg cttcctcatc gtcgcgcagc
    13621 gtaaaaaata aatgttacac tggaaggcac ccagtaatcc aggaaaccgt acttggaaat
    13681 gccggacgaa acctaagcag gccccgtccg acagcgacgg ccccatc
//
