LOCUS       c00410_gnlPro..        13786 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CDCLAIEN_410.
ACCESSION   c00410_gnlPro..
VERSION     c00410_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:44:41
            Original ID  :: gnl|Prokka|CDCLAIEN_410
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13786
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13786
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3786]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3786
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13786
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13786
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..1400
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg410_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-49, bitscore:
                     157.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIAGQVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYIAKSGRPGPVVLDFAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELI
                     NNAQRPLVLVGQGVELGNAQNELRAFIEKADMPCGCTLLGLSAIPTSHPLNKGMLGMHG
                     NLGPNVKTNECDVLIAVGMRFDDRVTGKLDTYAKQAKVIHLDIDHSEIDKNVKVDVPVL
                     GNCKYTLTMLTQLIRKNEHSEWIDSFTEYEKTEYEHVISKEIHPVDGALNMGEVVRAVS
                     EASNNEAVLVTDVGQNQMMAARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNIQELGTIMEQKAPVKIILLNNNYLGNVRQWQAMFFGHRYSFTPMLN
                     PDYMKIAEAYEIPARRVMKREELQAAIHEMLTTDGPFLLEACVIEEGNVLPMTPPGGSV
                     NQMLLEC"
     CDS             1411..1965
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg410_2"
                     /sec_met_domain="ALS_ss_C (E-value: 2.2e-19, bitscore:
                     59.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENIAGLLNQITAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTTQDVIEKVVKQIEKKIDVLQAHYFTDSEIYQHEIALYKVSTPEFQENPM
                     ASKVIRRYSARIVEVNPVFSIVEKNGMSEEITALYEELRGLGCVLQFVRSGRVAITTSC
                     FERVNEYLTQREEKYRQQKTE"
     CDS             1965..2708
                     /locus_tag="ctg410_3"
                     /transl_table=11
                     /translation="MMSENKVGTYRFVAEPFHCDFSGKLTMSVLGNHLLNCAGFHAADR
                     GFGIATLNENHYTWVLSRLAVELENMPCQYEGFSIQTWVENVYRLFTDRNFAILDKEGK
                     TVGYARSVWAMISMETRKPADLLTLHGGSIIDYVCDKKCPISKPGRIKVTEKAPVSEYQ
                     TRYSDIDINGHVNSIKYIEHILDLFPIEFFKEKRIKRFEMAYVAESYYGDILSFYREEV
                     EEKEYDIEVKKNGTDVVVRSKVIFI"
     CDS             2743..3786
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg410_4"
                     /sec_met_domain="IlvN (E-value: 1.8e-46, bitscore: 148.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.1e-41, bitscore: 131.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKATIVMCLLSDAAVMS
                     VWPTIKPYLTQGKALYFSHGFAITWSDRTGVVPPTDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             3986..4999
                     /locus_tag="ctg410_5"
                     /transl_table=11
                     /translation="MNLPPYYPTVKGITDYAVWQLVYPDSLLRANIAGEAVCTLRIDSL
                     GTVRCKYIEATHPLFAKAAEDVIEGMREWQPAKKAGRDIDTTIVFHIPFNPDVYSDRIW
                     RQQQVLESCRGQLVDSMPVFPDDIRSLVMGNMSWPDDKVDKAVAICRFTVNEKGEIVDI
                     RVIKGTHPAFDKESIRILSNFPRLIPAMKNRKSVPYDYFLTMRFWKEDLEHYLLYRECA
                     QEDLEKITWEPYRYSSYPGGTVALTQFINSHLKITPEMKATGKQGRVIYSFNVDIDGSM
                     KDFQLVRGLDPLMDAEALRVLQLVNERWSTGYYFNSKKWYREFYVNQFTIPIIFSW"
     CDS             complement(5093..6307)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OAD_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg410_6"
                     /sec_met_domain="OAD_beta (E-value: 1.4e-112, bitscore:
                     366.3, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENIDFGILFQGIGTMIESGWFLACARVFLILLGFLLIYLGWKGI
                     LEPMVMIPMGLGMIAINCGTLIMPDGNLGNLFLDPMLSDTDELMNTMQIDFLQPVYTLT
                     FSNGLIACFVFMGIGTLLDVGFLLQKPFASLFLALCGELGTFLTLPIANALGLSAQESA
                     SVAMVGGADGPMVLFTSLALAKHLFVPITVVAYLYLGLTYGGYPYLVKLLIPKRFRSIK
                     MTVKKAPKNYDAKVKLAFAAVLCAVLCFLFPVASPLFFSLFLGVAVRESGMKHIYDFVS
                     GPLLYGSTFMLGLLLGVLCDAHLLLDPKILKLLILGMLALLLSGIGGILGGYIMYYIKK
                     GNYNPVIGIAAVSCVPTTAKVAQKIVSKDNPDSFILGDALGANISGVITSAIITGIYIT
                     IIPLL"
     CDS             complement(6329..6742)
                     /locus_tag="ctg410_7"
                     /transl_table=11
                     /translation="MMGLTFLIGFFVAAIIKGIALAADSMDFYSSHLLELQRLRKIKKA
                     RARFIQLVWNNSPEEMEALGDSRENWNRGMNSDLRGKQEGGYYHGVSHGASQLNLIDYY
                     YPDTKMIYLKKREEMHNQQQKSTHVKKNLSMNK"
     CDS             complement(6927..7316)
                     /locus_tag="ctg410_8"
                     /transl_table=11
                     /translation="MKYFIAICTCILLLCSFNSTNKGGIIRECPPEVISSISMLSDDTN
                     SYRQLSTEKRYDAPNVKLSEVNLLCFTLRTPMFTKTSKPLSTIKVLCHYRILLPEQKFN
                     SLYPSINYVKSSCKYFIYTLGHILI"
     CDS             complement(7485..9617)
                     /locus_tag="ctg410_9"
                     /transl_table=11
                     /translation="MATLQTIRSKGPLLVVVIGLALFAFIAGDAWKVLQPHQGKQDVGE
                     VNGKTLTAQEYQKMVDEYTEVIKLTQGVSALNDDQLTQVKDQVWQSYVNNQLIAAEAAK
                     LGLTVSKAEVQAIIEEGTNPLLMQTPFRNPQTGAFDKDMLKKFLVDYAHLDASKMPAQY
                     VEYYQKMGAFWNFIEKTLIQSTLAEKYQNLIAKSLISNPVAAEDAFISRTEQSDVLLAA
                     IPYSSISDSTITVSNSEIKDLYNKKKGSFEQPVETRNIKYIDVLVTPSDEDRKEVLNEV
                     TEYATQLGTAADMNTFIRSTGSVVPFSEIAINKTVYPNDVVARLDSVTINEVYGPYYNQ
                     ADDSYNAFKIIAKQTAPDSIQYRQIQVYAEDAAKTATLADSIFNALKGGADFTDIAKKY
                     GQTGEATWLTARNYEGAALDADNAKYINTLINSNVKELTNLQIGQANVILQVLDKKAMK
                     DKYKVAVIKRPVEFSKETYNKAYNDFSQFVAQNTTMDKIIANAEESGYRLLERADFRSA
                     EHRVGGVKGTREALKWIFAAKEGEVSPLYECGENDHLMVVALEKINPAGYRNINLVADM
                     LKAEIIKDKKAEKLIAEMKSASSIDQVKSMANAVSDSVKHITFSAPAYVSVTRASEPAL
                     GAYASKAEINKLTGPIKGNAGVYMIQVYNKEKSAEEFDAKNEENNLSNMAGRYASSFIN
                     DLYKKADVKDDRYLYF"
     CDS             complement(9723..11030)
                     /locus_tag="ctg410_10"
                     /transl_table=11
                     /translation="LQIALELIRYANSLTIMGIIIQILITMAFSAFFSGMEIAFVSSNK
                     LRFEMDRNNQSINSRILSIFFHNPNNFISTMLVGNNIALVIYGILMAQVIEQNLLSGLI
                     DNHFLLVLIQTIISTLIILVTGEFLPKTLFKINPNFTLNIFAVPTYICYVLLYPISKFA
                     SGISNILLYIVGIKTNKEANEKAFTKVDLDYFIQSSIQDAQNEQDIDTEVKIFQNALDF
                     SNIRIKDCMVPRTEIVAIEYGTPIEELKARFIESGISKIIVYKENIDNIIGYIHSSEMF
                     REQTDWTKSVRQLPIAPETMGAHKLMKLFMQQKKSLAVVVDEFGGTSGIVALEDLVEEI
                     FGEIEDEHDTTSYIAKSVGDNEYILSGRLEIEKANELFSLDLPENDDYQTIGGLILHQY
                     QSFPKIHEEIIFDKFHFKIIKVTATRIELVKLKVIE"
     CDS             complement(10996..11478)
                     /locus_tag="ctg410_11"
                     /transl_table=11
                     /translation="LGVTTLISDSGITRYKIITEEWEIYDKKNPPYWAFEKGVYLEKFD
                     SLFHIDASIKADTAYYYEKKKLWELRSNVHIRSQRGDKFDTDLLFWDEKQERVYSDKFI
                     RIEQEDKIITGYGFESNQQMTEYQIYNNTGIFTVEDTAPADSTKAVANSTRTDSIR"
     CDS             complement(11643..12878)
                     /locus_tag="ctg410_12"
                     /transl_table=11
                     /translation="LKNISIYTEYVKTNNFKDAYTPWMSVFTEAPKAQVSTYTNGAKIL
                     RALIAGEKDAAKQKQYFNELMKVHDQRIQYLDDLNKLVKRDATKGSIIGMKAHDYFTMG
                     GQDMNEAYNMFKEAIELEKENSDYFVLQEFMDAAARKMKSDESYKEQFIQDYLFASGVA
                     DGALKAATKENDKKLLKVAKDNIDAFFINSGVATCDNLQAIYAPKVEQNKTNLDYLKQV
                     ISVMQMLNCTEQEAYFAASEAAHAIEPTAETAVGCGYMYYKKGDMDKCIDYFDQAINLE
                     QDQLKKADYAYKTAAILFSKKQLSKAKQYALKAISLDGNNGKPYILIANMYASSPNWSD
                     EAALNKCTYFAVIDKLQKAKSVDPSVAEEANKLISTYAAHTPKDADLFFLSLKKGDSVT
                     IGGWIGETTTIR"
     CDS             12911..13126
                     /locus_tag="ctg410_13"
                     /transl_table=11
                     /translation="LIRLTLRSERKKLSYLRKERTALLPSSFSSYINLVVVIYLLLSIL
                     LINFPLHEPTFIESKSNIDSQIIFFH"
ORIGIN
        1 tggtgattgc cgggcaggta ggagcgtcct ttttaggtac ggatgctttt caggaagtgg
       61 atctggtggg catcactcag cctattacca aatggagtta ccaaattcgt cgtgcggaag
      121 atgtagcttg ggctgtagcc cgtgctttct atatagctaa aagcggacgt cccggtcctg
      181 tcgttttgga ctttgccaag aatgcacaag tggagatggt ggattatgaa ccgatgaagc
      241 ttgattttat ccgtagttat gatccagaac ctaatcctga taaggaatct cttcaggagg
      301 ctgccgaatt gataaacaat gctcaaaggc cattagtgtt ggtaggacag ggggtagagt
      361 taggtaatgc gcaaaatgag ttacgtgcat ttatagaaaa agccgatatg ccttgtggct
      421 gtactttgct gggactttcg gctataccaa cttcgcatcc tttaaacaaa ggaatgttag
      481 gtatgcatgg aaatctgggg cccaatgtca aaactaatga atgtgatgtg ttgattgctg
      541 taggtatgcg ctttgacgat cgtgtaactg gaaaattaga tacatatgct aaacaggcaa
      601 aggtgattca tttggatatt gaccattctg aaatagataa gaatgtaaaa gtggatgtac
      661 ccgtattagg taattgtaaa tatacgctaa ctatgctgac gcaacttatc cggaagaatg
      721 aacattccga atggattgat agctttactg aatatgaaaa gacggaatat gaacatgtta
      781 tcagtaaaga aattcatcct gttgacgggg cgttgaatat gggtgaagtg gtgcgtgcgg
      841 taagtgaggc ttcgaacaac gaggctgtat tggtgacaga tgtaggacag aaccaaatga
      901 tggctgctcg ttattttaaa tacagtaaga accgtagcat tgtaacttcg ggtggattgg
      961 gaacgatggg attcggtctt cccgctgcta taggcgctac tttcggtcgc ccggatcgta
     1021 ctgtatgcgt atttatgggg gatggcggtt tgcagatgaa tattcaagaa ttgggaacta
     1081 tcatggagca aaaagcaccg gtaaagatta ttttattgaa caataactat ttgggtaatg
     1141 ttcgtcaatg gcaagctatg ttttttggtc atcgttattc atttactccg atgttgaatc
     1201 cggattatat gaagattgcc gaggcatatg agattcctgc ccgccgtgtt atgaagcgtg
     1261 aggaattgca ggctgctatc catgaaatgt tgactactga cgggccattc ctgctggaag
     1321 cttgtgtgat agaagaggga aatgtgttgc cgatgacacc tccgggaggc tcggtgaatc
     1381 agatgttact ggaatgctaa tttaataatt atggacaaga cattatatac attaatcgtt
     1441 cattcagaaa atatcgccgg tttgctgaac cagattacgg cagtgtttac tcgccgccaa
     1501 attaatatcg aaagtcttaa tgtttctgca tcttccatca agggggtgca taaatatact
     1561 attactgctt ggaccaccca ggatgtgata gaaaaagtgg tgaagcagat tgaaaagaaa
     1621 atagatgttt tgcaggcaca ttattttact gatagtgaga tttatcagca tgagattgct
     1681 ttgtacaagg tttctactcc tgaatttcag gagaatccta tggcatctaa agttatccgc
     1741 cgttatagtg cccgcattgt agaagtgaat ccggttttct ctattgttga aaagaatggg
     1801 atgagtgagg aaattactgc tctttatgag gagttgcgcg gattgggatg tgtgttgcag
     1861 tttgtccgtt cgggacgtgt ggccattact accagctgtt tcgagcgtgt gaacgaatat
     1921 ctgacccaac gcgaggaaaa gtatcgccag caaaaaacag aataatgatg agtgagaata
     1981 aagtaggaac atacagattt gtggcagaac cctttcactg tgatttcagt ggaaagttga
     2041 ccatgagtgt gttgggtaat catttactga attgtgccgg ctttcatgct gccgaccggg
     2101 gtttcggaat tgctacgctc aatgagaatc attatacatg ggtactttcc cgtttagctg
     2161 tagagttaga gaatatgccc tgtcaatatg agggtttcag tattcagaca tgggtagaga
     2221 atgtttatcg tctttttaca gaccgtaatt ttgcaatttt ggacaaggaa ggaaagactg
     2281 tcggatacgc ccgttctgta tgggcgatga tcagtatgga aactcgcaaa cctgctgacc
     2341 tgcttacgct tcacggaggt agtatcattg attatgtatg cgataagaaa tgtcctataa
     2401 gcaagcccgg tcgtattaag gtgacagaga aagctccggt ttctgaatac cagaccagat
     2461 atagcgatat tgatattaat ggtcatgtga acagtattaa gtatatagaa catattctcg
     2521 atttgtttcc tatagagttt tttaaagaga aacggattaa acgttttgag atggcttatg
     2581 tagctgagag ttattatggt gatatattga gtttctaccg cgaggaagtg gaggagaaag
     2641 aatatgatat agaggtgaag aagaatggca cagatgttgt cgttcgtagt aaggtgatat
     2701 ttatttagaa tctaattttt aatttttaat ttataattta aaatggcaca attgaatttt
     2761 ggcggcgtta cagaaactgt agttatccgc gatgaatttc ctttggaaaa agcacgtgaa
     2821 gtattgaaag atgaaacaat cgctgtgatc gggtatggtg tacagggacc gggacagtct
     2881 ttgaatctcc gggacaatgg tttcaatgta attgttggtc agcgtccggg aaaaacatat
     2941 gaaaaagcag ttgctgacgg atgggttccg ggtgaaactc tgtttggtat tgaagaggct
     3001 tgtcagaaag cgactatcgt aatgtgtctg ttatctgatg cagctgttat gtctgtatgg
     3061 ccgactatca aaccttactt gacccaaggc aaggcacttt atttctctca tggctttgcc
     3121 attacttgga gtgaccgtac aggggtagtt cctcctactg atattgatgt gatcatggta
     3181 gctcctaaag gttcgggtac ttcactgcgt accatgttct tggaaggtcg tggcttgaac
     3241 tcttcatacg ctatctatca ggatgtaacc ggtaaggctt atgaacgtac tattgcattg
     3301 ggtattggta tcggttcagg ctatttattc gaaacgactt tccagcgtga agcaacttct
     3361 gacctgacag gtgaacgcgg ttctttaatg ggggctatcc aaggattgtt gttggctcag
     3421 tatgaagtat tgcgtgaaaa cggacatagt ccttctgaag catttaatga aactgtagaa
     3481 gaattaaccc agtcattgat gcctttgttt gctaagaatg gtatggactg gatgtatgct
     3541 aactgctcta ccactgctca gcgcggtgca ttggattgga tgaccccatt tcacgatgct
     3601 atcaaacccg tagttgaaaa gttatatcac agtgtgaaga ctggcaacga ggctcagatt
     3661 tctatcgatt ctaactctaa acccgattat cgtgaaaaat tggaagaaga attgaaggca
     3721 ttgcgtgaaa gcgaaatgtg gcagactgct gtaaccgtac gtaaacttcg tcctgaaaat
     3781 aattaatagt tagtatttaa tgtagaaagc ggggatgcga tgaggtatct ccgctttctt
     3841 ttatatatat taatgttagt ggtgttgttt atatcatgtg tagtcgctaa ttttgtgaaa
     3901 acttgactta ggcatgaata atagattatc acttttatta atagggtgca tatttccctt
     3961 tctatctttt tatgcacaaa agaacatgaa tctcccgcca tattatccta cagtaaaagg
     4021 tattacggat tatgctgtgt ggcagctcgt atatccggat tctttattaa gggccaatat
     4081 tgcaggtgaa gctgtgtgta cgctccgcat tgatagtttg gggactgtcc gttgtaaata
     4141 tattgaagcc actcacccct tgtttgctaa ggcggccgaa gatgtgattg agggtatgcg
     4201 tgaatggcag cctgcaaaga aagcgggtag agatatagat actactatcg tctttcatat
     4261 tccttttaat cctgatgttt acagtgaccg catttggcgg cagcagcaag ttctggaatc
     4321 ttgcagagga caacttgtcg attccatgcc tgtctttcct gatgatattc gtagtcttgt
     4381 tatgggaaat atgagttggc ctgacgataa agtggataaa gccgtcgcta tttgccgttt
     4441 tacggtaaat gaaaaaggag aaattgtgga tatccgtgtg ataaaaggta ctcatccggc
     4501 ttttgataaa gagtccatac gtattctttc taattttccc cggttgattc ctgctatgaa
     4561 aaacagaaaa tctgtgccat atgattattt tttaactatg cgtttttgga aagaggatct
     4621 ggagcattat ttattatata gggaatgcgc acaggaagat ttggaaaaga tcacttggga
     4681 gccttataga tactcttctt atcccggtgg tactgttgct ttgacgcaat ttattaattc
     4741 tcatctgaaa attactcccg aaatgaaggc tacgggaaag cagggacggg tgatttatag
     4801 tttcaatgtg gatatagatg gttcaatgaa agattttcag ttggtgagag gacttgatcc
     4861 attaatggat gccgaagcat tgcgggtact tcaattagtg aatgaaagat ggagtacggg
     4921 gtattatttc aattcaaaga aatggtatcg ggagttttat gtgaatcaat tcaccattcc
     4981 aattattttt agttggtagt ggtggcagag ggcagatacg cggactgccc tctgcgaaaa
     5041 tgatagcatt attaaaagtg gatgaaattt attaggtagg attcatgctg tttcataata
     5101 gcgggatgat tgtgatataa atacctgtaa taattgctga agtaataact cccgatatat
     5161 tggctcctag tgcatctcct aggataaatg aatcaggatt gtctttactg acaatctttt
     5221 gtgccacttt ggcagtagtt ggtacgcagc ttacagcagc aatgccaatg actggattat
     5281 aatttccttt cttgatatag tacatgatat atccgcctaa aatacctccg atacctgata
     5341 gtaacaatgc caacatacct agtatcagca attttaagat tttaggatct agtagcagat
     5401 gagcgtcgca aagcactcct aataataatc ccagcataaa agtagaaccg taaagcaatg
     5461 gaccgctgac aaaatcataa atatgtttca tccctgattc acgtacagcc actcctagaa
     5521 atagagagaa aaacagggga gaggccactg gaaaaaggaa gcagagtaca gcgcagagta
     5581 ccgctgcgaa agcaagcttt accttggcat cgtaattctt cggcgctttc tttacggtca
     5641 ttttgatgga acggaaacgt ttgggaatca gtaatttaac caaataggga taaccgccgt
     5701 aagtcaatcc taaatagaga taagctacca cggtaatcgg tacaaacaaa tgcttggcta
     5761 atgccaatga agtgaacagt accatcggac catctgcacc tcctaccatg gctacagaag
     5821 cactctcttg tgccgataag ccaagtgcat tggcaattgg caatgtgaga aaggttccta
     5881 gttctccgca aagtgccaga aacaaactag caaaaggttt ttgtagcagg aaacctacat
     5941 ctagcaaggt tccgattccc atgaagacga aacaagcgat gagtccatta ctgaatgtga
     6001 gggtgtaaac cggttgcaga aaatctattt gcatggtatt catcaattcg tctgtatccg
     6061 agagcatggg atcaagaaaa agattgccta gatttccatc cggcatgatt aatgttccac
     6121 aattgatggc tatcataccg agtcccattg gaatcatgac catgggctcc aatattcctt
     6181 tccaacctag ataaatgagt agaaatccca aaagaattaa aaaaacgcgc gcacaggcaa
     6241 ggaaccaacc gctttctatc attgtaccaa tgccttggaa aagtattcca aaatctatat
     6301 tttccatatc taattgttga ttttcaggtt atttattcat tgaaagattc tttttcacat
     6361 gagtgctttt ttgttgctga ttatgcattt cctcccgttt cttaaggtag atcatctttg
     6421 tgtccggata gtaataatct atcagattta attgggatgc tccatgactg acaccatggt
     6481 agtaaccacc ttcctgtttt cctctcagat cgctgttcat tcctcggttc cagttttcac
     6541 ggctgtctcc tagagcttcc atctcttctg gagaattatt ccatactaat tggataaaac
     6601 gggcacgtgc ttttttgatt tttcttaaac gttgaagttc caataggtgg gagctataga
     6661 aatccataga atctgctgcc agcgctattc ctttaataat agcagcgaca aaaaaaccga
     6721 tgaggaaagt aagccccatc atggccaatg tggataaaaa taagtgtagc attataatat
     6781 aaatgtgatt tagtaggtaa aatagtatta aattccgagt tatagtgata ttcacatcgt
     6841 agtgtcacac atatatgtat acacgccgat agaataattt caatccggaa tgataatgat
     6901 caagaataag taagaggaaa tagctgctaa atcaaaatat gtcctaatgt gtaaatgaag
     6961 tatttacacg aggattttac ataattaatg ctaggatata ggctattaaa tttttgttca
     7021 ggtagaagaa tacggtaatg gcaaagtact ttgattgtag ataagggttt tgatgttttg
     7081 gtaaacatcg gagtacgtaa agtgaaacat aaaagattta cttcggatag tttcacatta
     7141 ggagcgtcat atcgtttttc tgtagataat tggcgatagg aattcgtatc atccgaaagc
     7201 atggatatag aagatatgac ttctggcggg cattcgcgga taattcctcc tttatttgta
     7261 ctattaaagc tacataacaa aaggatacac gtacatatag caataaaata cttcataatt
     7321 actattgcaa acataatgat aaaaatggga atacggaacg taaacgaata gattttataa
     7381 attatttcat ctttaatttt tgcgaaaata ggaataagac aaaacaggct gtatcgacga
     7441 attttcgata cagcctgttt tgtcttattg ataactttct gatattagaa atataagtaa
     7501 cggtcgtctt ttacatcagc tttcttatac aggtcattga tgaaactgct agcataacgc
     7561 cctgccatat tggacaagtt gttttcttca ttcttggcat caaattcttc tgcactcttt
     7621 tctttgttgt aaacctgaat catgtaaaca cctgcattac ctttgatagg accagttaac
     7681 ttatttattt cagctttact tgcataagca cctaaagctg gttcgctagc gcgagttact
     7741 gaaacatatg ccggagcaga aaaagttata tgttttacag aatcgctaac tgcatttgcc
     7801 atacttttta cttggtcaat gctgcttgca cttttcattt cagctatcag tttttcagct
     7861 tttttatctt tgatgatttc tgctttcagc atgtcggcaa caagattaat attacgatat
     7921 ccggcaggat taatcttttc aagagcaact accatcaagt gatcattttc accacattca
     7981 tacaatgggg acacttcacc ttccttggct gcaaaaatcc atttcaacgc ttcacgagtt
     8041 ccttttacac cacccacacg gtgttctgcg ctacggaaat cagcacgttc taacaagcga
     8101 tatccgcttt cttctgcatt ggcaataatt ttatccattg tagtgttctg tgctacgaat
     8161 tgactgaaat cattgtatgc tttgttgtat gtttctttgc taaattcaac cggacgttta
     8221 atcactgcaa ctttatattt atctttcata gcttttttgt ccaatacttg aagaataacg
     8281 ttagcttgtc cgatctgaag attggttaat tctttgacat tagagtttat caatgtgtta
     8341 atgtatttag cattgtctgc atctaatgca gcaccttcat agttgcgtgc agtcaaccaa
     8401 gtcgcttcac ctgtctgacc atattttttt gcaatatcag taaagtctgc tccacctttc
     8461 agtgcattaa aaatactatc ggctaaagtt gcggttttag cagcatcttc ggcatatacc
     8521 tgaatttgac gatattggat tgagtcggga gctgtctgtt tggcaataat tttaaaagca
     8581 ttatatgaat catctgcttg gttatagtaa ggaccatata cttcgttgat agttacagag
     8641 tccaaacgag caactacatc attaggatat acagtcttgt tgattgcaat ttcagaaaaa
     8701 ggaactacag aaccggtgga acggatgaat gtgttcatgt ctgcagcagt acctagctgg
     8761 gtagcgtatt cggttacttc gtttaatacc tctttgcgat cttcgtcaga tggagtaacc
     8821 aatacatcaa tatatttgat gttacgagtt tcaactggct gttcaaaaga accttttttc
     8881 ttgttataca gatctttgat ttcactattt gaaactgtaa tagttgaatc gctgatagaa
     8941 gaatagggaa ttgcagctaa taaaacgtct gattgttcag tacgtgatat aaaagcatct
     9001 tcagctgcaa ccggatttga aatcaatgat tttgcaatca ggttctgata tttttcagct
     9061 aaagtggatt gtatcaaagt cttttcaata aaattccaaa aagctcccat cttttgatag
     9121 tattctacat attgtgcagg cattttgctt gcgtccagat gagcgtaatc cactaggaat
     9181 tttttcagca tatctttgtc gaaagcaccg gtttgcggat tgcggaacgg ggtttgcatc
     9241 aacaatgggt tagtaccttc ctcgatgatt gcttgaactt cagctttgct gacggtcaac
     9301 cccaattttg cagcttccgc tgcgattaat tggttattta cgtaagattg ccatacttgg
     9361 tctttcactt gagtcagttg gtcgtcattt aatgcagaaa caccttgtgt caattttatg
     9421 acttctgtgt attcatctac cattttttga tactcttgtg ctgtaagtgt ttttccattt
     9481 acttcaccta cgtcttgttt accctgatgt ggttggagaa ccttccatgc gtctccggca
     9541 atgaatgcga agagggcaag tccgattaca acgaccaaca gagggccttt acttctgatt
     9601 gtttgtaatg ttgccattta attttactat ttttgtttat tgttttttta tacttcatag
     9661 atttagcgca cgaagataca aaaaatgcag cttacaagct attttattgt gaaaaaaatc
     9721 tgttattcga ttactttcaa ctttactaat tcaattcttg ttgctgttac tttaattatt
     9781 ttgaaatgga atttatcgaa aatgatctct tcatgtattt tggggaaact ttggtattgg
     9841 tgcaggatga gtccaccgat agtttggtaa tcatcatttt ccggtaggtc aagtgagaac
     9901 aattcattgg ctttttctat ttccagacgt ccggaaagga tgtattcatt gtcaccgacg
     9961 gatttggcaa tgtaagaagt tgtatcatgc tcatcttcta tttcgccgaa aatttcctcc
    10021 actaaatctt ctagcgccac gatgccggat gtacctccga attcatcgac tactacagct
    10081 aaggatttct tttgttgcat aaataatttc atcagcttat gcgctcccat cgtttcagga
    10141 gcaataggca attggcggac actcttagtc cagtctgtct gttcacgaaa catttcagag
    10201 gaatgtatat aacctataat attgtcaatg ttttctttat agacaataat tttacttatt
    10261 ccgctttcaa tgaagcgggc ttttaattct tctatgggag ttccatattc gatagcaaca
    10321 atttcggttc taggtaccat acaatcctta attctaatat tcgaaaaatc tagtgcattt
    10381 tggaatatct tgacttcggt gtctatgtct tgttcatttt gagcatcttg tatactactt
    10441 tgaataaagt aatctaggtc gactttagta aaagcttttt cattagcttc tttatttgtt
    10501 ttaatgccta caatgtaaag taatatattg gatattcccg aagcaaactt gctgatggga
    10561 tagagtaaga catagcaaat gtaagtggga actgcaaaaa tattcagagt gaaattgggg
    10621 ttaatcttaa ataaggtttt aggtaggaat tctcctgtga ccaaaatgat taatgtggaa
    10681 ataattgttt ggattagtac taataaaaag tggttgtcta tcaatcctga caacaagttt
    10741 tgttcaatga cttgtgccat caatataccg taaataacta aagcgatgtt gtttcctacc
    10801 aacatggtag agataaaatt gttcggatta tgaaagaaga tggaaagtat acgtgaattt
    10861 atgctttggt tgttacgatc catttcaaaa cgtaatttat tggatgaaac aaaggctatt
    10921 tccattccgg aaaaaaaagc ggaaaaagcc attgtaataa gaatctgtat aataataccc
    10981 ataatagtga gtgaattagc gtatcgaatc agttctagtg ctatttgcaa cagcttttgt
    11041 actgtctgct ggtgctgtat cttctacagt gaaaatacct gtgttattat aaatttgata
    11101 ttctgtcatt tgctggttag attcaaatcc ataaccggta atgattttat cttcttgttc
    11161 aatgcggata aatttgtcag aatagaccct ttcctgcttt tcatcccaaa agagcagatc
    11221 tgtgtcaaat ttgtcgcctc tttggctgcg gatatgcaca ttgcttctca attcccaaag
    11281 tttctttttc tcgtagtaat aagctgtatc ggcttttatg ctggcatcaa tatggaatag
    11341 ggaatcaaat ttttccaaat aaactccttt ttcaaatgcc caataaggag gattcttttt
    11401 atcataaatt tcccattctt ctgtgataat tttgtagcgg gtgataccgg aatcggatat
    11461 aagggtagta actcccaatg ttttcatgct gggcaacgaa tctctttctg taatagcttc
    11521 tgccagattc ttttcgcctc ttgagcatgc tggaaataaa acaaacataa cagttgtcca
    11581 aacggcaact gttatgttta agaatataaa gtgtgatttt tgttcttttt cagacgacat
    11641 aattatctga tagttgttgt ttcaccaatc catccgccga ttgtaacaga gtcacctttc
    11701 tttaaactga ggaagaacaa atcagcatct ttgggggtat gggctgcata agtactaatt
    11761 agtttgtttg cttcttcagc aacactagga tctacgcttt ttgctttttg caatttgtcg
    11821 ataactgcaa aataagtgca tttgttcaat gctgcttcat cactccaatt aggacttgat
    11881 gcatacatgt tagcaatcaa aatgtaaggt ttaccgttgt tgccatctaa cgagatcgct
    11941 ttcagtgcat attgttttgc tttgctcaac tgtttcttac taaataaaat ggcagcggtt
    12001 ttatatgcat aatcagcttt ctttaattgg tcttgttcta aattgatagc ttgatcaaaa
    12061 tagtcgatac atttgtccat atcgcctttc ttataataca tgtatccgca acctacagcc
    12121 gtttctgctg tcggttcgat ggcatgtgca gcttcagatg cagcaaagta agcttcttgt
    12181 tctgtacagt ttaacatctg cattacagag ataacctgtt tcagataatc caaattagtc
    12241 ttgttttgct caactttcgg agcataaatt gcttgtaaat tatcacaagt tgccacacca
    12301 ctattaatga agaatgcgtc aatattgtct tttgccactt tcaataattt tttgtcattt
    12361 tcctttgtag cggctttcaa agctccatca gcaactcctg atgcaaataa ataatcttga
    12421 atgaattgtt ctttgtatga ttcatcactt ttcattttac gggcagctgc atccatgaac
    12481 tcttgtaata caaagtagtc agagttttct ttttcaagtt caatggcttc tttgaacatg
    12541 ttatatgctt cattcatgtc ttggccaccc attgtgaagt agtcatgggc cttcataccg
    12601 atgattgagc cttttgtagc atctctttta accaacttgt tcaaatcgtc cagatattgg
    12661 atgcgttggt cgtgaacttt catcagttcg ttaaagtatt gtttttgttt agctgcatct
    12721 ttttcaccgg ctattaaggc acgaagaatt tttgcaccat tagtataagt gcttacttga
    12781 gctttggggg cttctgtaaa tacactcatc caaggagtgt aagcatcctt gaaattgtta
    12841 gtcttaacat actcagtgta aatactgata tttttcaagc atcggatact gtcttcacca
    12901 tgtccgaatc ttgatccgtc tgacgctccg gtctgagcga aagaagctgt cgtacctaag
    12961 gaaagaacga acagcgctgt taccatcttc attttcatcg tatataaatt tagttgttgt
    13021 tatttatttg cttctctcca ttttattaat caactttcca cttcatgaac caacgttcat
    13081 tgaaagtaag tccaatattg attctcaaat aattttcttc cattaatcct ttaaatttag
    13141 gactgacttt aatgtattgc ccggaaatgt tcagcataga tttactttgg aacatgggaa
    13201 gtccaaaccc aatactgaca ccatattcgc gtgcaccgtc ttggaaactg gttgttcctg
    13261 tgtccggact agtatagctg accttattat aaggacttga ataataggcc cccatacggt
    13321 aacgaatacg tttcagatag ttgtggctga tataacttgg tacgaattcc gcaccaaaag
    13381 ctatttttgt acggctattc atttccacac tttctttatt gaacttactc caagctagat
    13441 cggctgtatt ccacttttgt aaagtatagt caacccctat agttaagcgg ttatcatata
    13501 catatgtaag ccctatacca aatgtatgtg gcattttaaa cggattcgga atagtatcgc
    13561 cagtttgtga ctgtacatag atagaaccat tactttccgc acctgtttga tgatacttat
    13621 atgcatctcc atgcaaggta cgtcccaagg tataaacagc acctatatta atagtgtttt
    13681 ttttatttaa cttataagta tactgtaaac caaaatctaa tttataatca ctgatagaaa
    13741 atttgtctaa tttaatacta cgtgtatctg tcgctccaat agttgt
//
