LOCUS       c00437_gnlPro..        15262 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CDCLAIEN_437.
ACCESSION   c00437_gnlPro..
VERSION     c00437_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:44:41
            Original ID  :: gnl|Prokka|CDCLAIEN_437
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15262
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..873
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1016:4Fe-4S dicluster domain (Score: 40.5; E-value:
                     1.1e-12)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_1"
                     /sec_met_domain="Fer4_7 (E-value: 2.5e-13, bitscore: 40.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 2.1e-10, bitscore: 30.1,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 5.1e-09, bitscore: 25.9,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.3e-09, bitscore: 26.6,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_17 (E-value: 2.6e-08, bitscore: 24.3,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 1.1e-10, bitscore: 31.0,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.1e-05, bitscore: 15.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SKKFAVYEDPRIAKVSEVLPQANCGGCGYPGCSGFAGACVKAADA
                     GSLEGKLCPVGGAPVMEKVAALLGLEAVAAEPKVAVVRCNGSCENRPRTALYDGAKSCA
                     IAHATSGGETGCTFGCLGCGDCVEVCQFDAIHMNPETGLPEVDEEKCTACGACSKACPR
                     KIIEIRPKGKNNRRVVVMCVNKDKGAVANKACKASCIGCGKCVKVCPFEAITLENNLAY
                     IDPAKCKSCRKCESECPKGAIQAINFPPRKPKVEVPAGEAAAKPAAKVEASKVETPEAV
                     KADAPKAEA"
     protocluster    1..15262
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:5262]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..5262
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15262
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15262
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             913..2250
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_2"
                     /sec_met_domain="Fer4_7 (E-value: 1.5e-09, bitscore: 28.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="SLBB (E-value: 2.5e-17, bitscore: 52.5,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 1.5e-53, bitscore:
                     170.7, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 1.2e-31, bitscore: 98.7,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.4e-05, bitscore: 15.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKTFRIGGVHPAENKLSAGKAIETLALPKQAVFPLSQHIGAPATA
                     IVKKGDVVKVGTKIAEAGGFVSAAIFSSVSGKVNKVDAVIDASGYRKPAIFIDVDGDEW
                     EESIDRSSTLVKECALTPEEIVAKVKNAGVVGMGGACFPTHVKLSPPPGCKAECVIINA
                     VECEPYLTADHRLMLEKADEVLVGVSILMKAAKVTKGYIGIENNKPDAIKLMTEKAAQY
                     PGIEVVPLQVKYPQGGEKQLIDAVIGRQVPAPPAIPINVGAVVQNVGTAFAVYEAVQKN
                     KPLFERIVTVTGKSVRNPSNFLTRMGTPMSQLIDAAGGLPEDTGKVIGGGPMMGKALVN
                     TEVPICKGSSGVLIMNDKEAARAEAQPCIRCAKCVNVCPMGLEPFLLATLSAHKDWERV
                     EKEDVMSCIECGSCQFTCPSHRYLLDYIRLGKGTVGGIIRARNAKK"
     CDS             2265..3254
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_3"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 1.6e-120,
                     bitscore: 391.8, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANKLIVSLSPHVHSGDSIQKNMYGVLIALIPALLVSFYMFGLGA
                     VVVTLTSVAACVFFEWAITKFILKRERSTICDGSAIITGVLLAFNLPSNLPLWIIIIGA
                     LVAIGVGKMTFGGLGCNPFNPALVGRIFLLISFPVQMTSWPLVQQWGSYTDAETGATPL
                     ALMKMAVKGDVNALGQLPDTLSLFLGNNPGSLGEVSALALLLGLGYMLWKKIISWHIPV
                     SILVTVFVFAGLMHLVDPVAYASPLAHLFTGGLMLGAIFMATDYVTSPMTHKGMIIYGV
                     AIGFLTVVIRLFGAYPEGMSFAIFIMNAFTPLINTYCKPKRFGEVVKK"
     CDS             3251..4042
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_4"
                     /sec_met_domain="FMN_bind (E-value: 2.5e-22, bitscore:
                     69.3, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLESSLKNMVIVLTAITVIATGLLAYVNQLTAGPIAEANAKAL
                     SDAIAVVVPGFDNNPAEAPETIELDGATYKIYKATKGGEFIGAAVESSANGFGGALSVL
                     VGFDKEGNIIDYSLLSHAETPGLGSKAADWFKKGAKGDITGMNPGQGALVVNKDGGQID
                     AITASTITTRAFLKAVNNAYAAYSGQNVDGASGATQQVSETVAENATACDAQCEGNEAC
                     KQVCDSTACKTVCSDKCDPANCDKADCKKVECPKQDCKNKK"
     CDS             4057..4641
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_5"
                     /sec_met_domain="Rnf-Nqr (E-value: 4.1e-71, bitscore:
                     228.5, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNFKVLMNGIVKENPTFVLLLGMCPTLGTTSSAINGMGMGLATA
                     FVLICSNVVISAIKNLIPDMVRIPAFVVVIASFVTLLQMIMQAYVPALYATLGLFIPLI
                     VVNCILLGRAEAFAAKNGPVPSFFDGLGMGLGFTLALTILGGVREFLGTGKLFDITIMP
                     EQYGMLIFVLAPGAFIALGYLIAIVNKLKKA"
     CDS             4660..5262
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg437_6"
                     /sec_met_domain="Rnf-Nqr (E-value: 3.7e-64, bitscore:
                     205.8, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYILIFITAIFVNNIVLSQFLGICPFLGVSKKVETATGMGAAVA
                     FVLTIATIVTYLIQKFVLDAFGLEYLQTIAFILVIAALVQMVEIILKKVSPALYQALGV
                     FLPLITTNCCILGVAILVIQKDFDLLTGVVYAFSTALGFALAMVLFAGIREQLSLVNIP
                     KGMQGMAIALVTAGLLAMAFMGFSGVDKGLGVLFGIE"
     CDS             5403..6299
                     /locus_tag="ctg437_7"
                     /transl_table=11
                     /translation="MAMTLIVLAATMGNKYGGLKQLEGIGPNGETILDFSIYDAVRVGF
                     DKIVFVISRHFEQEFKKLVSGKYEHVVEVEYVYQDVETIPEEKRNPKRKALYGSVRAVL
                     MGEELIDSPFGVINAVNFYQRESFELLYDNLVMLGEADYHSFNICYRLRNVLAESGGVT
                     RGICEVDEKGYLLSVTDRVGVERISGNPMYPNELHKWVALDDNSLVSMNMWGFTPQVFG
                     EMKKAFDKFIDENGMDMKAHYSIPAFMNERIADGVRVKVIETPARWMGLVSHDDKIQVL
                     LRINDMIRKGIYPSKLF"
     CDS             6332..7366
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg437_8"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 3.6e-53, bitscore:
                     170.9, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKERILVTGGTGYIGSHTVVELQNSGYDVVIVDNLSNSSADVVDN
                     IEKVSGIRPAFEKLDCLDFEGMDKLFTKYPGIKGIIHFAASKAVGESVQKPLLYYRNNL
                     VSLINLLELMPKHGVEGIIFSSSCTVYGQPDVLPVTEEAPIKKAESPYGNTKQINEEII
                     RDTVASGSPINAIMLRYFNPIGAHPTALIGELPNGVPQNLLPYVTQTAMGIREKLSVFG
                     DDYDTPDGSCIRDYIYVVDLAKAHVIAMDRILNNKQKEKVEVFNIGTGKGVSVLELINT
                     FEKATGVKLNYQIVGRRAGDIEKVWANPDFANKELGWKAEANLEDTLRSAWNWQLKLRE
                     RGIQ"
     CDS             7658..9535
                     /locus_tag="ctg437_9"
                     /transl_table=11
                     /translation="MKTKFWIICLSVFFVSCLRNMHDIYTGGGEEEEEKINKDDFFDFT
                     TVRNSQLIIDYGMKVQTAFYLYDEYPMELVENTWEFKDINPIYAASTDMNGRFFSKVSL
                     PAYLKKVWLVTDNVLVVSPVELELLSDGLTFNYVDYKAQLSADGRSRAVMGGVSYPDGY
                     DVLGNWNENGVPDYLLPEKLDIPGAFLERCSNLSRSIVVDNRNLLERFPELRTSGSNDM
                     VITKSTGLVATYFNFSSTTWEDMVAYYTYKEGESVDMATIKKTILIPRSSRNAPKSLVG
                     EQIKLKYWNKEQSKYEDEFPQGTHIGWILLGMGFGKEKGVFPRYSNPAYNDNKEQRSVL
                     LSDPELDNCFFMAMEDNVDMRFNDVQFAIMASASSSVEPTPNIPDEVNKGEISYVVKGS
                     LAYEDNWPDKNDYDMNDVVIYYSSTVVKDKSSNALVRTTTTFTPMNDGATYTNGFGFQL
                     DYVGKEHIDLVQVSQEGNVIGKNFEPGIEKPVLILFSDIKPVLKKPVTVVIGFKKYDKV
                     SDMDAYPPYNSFIFVNKRSHEVHLSGYKPTSVADESLRGTGSDLSQDSNGTPMYYIAED
                     NMPFAINISNSEFRWPSEKVSITTYYPEFKQWRDSFGADYKDWYLHPKE"
     CDS             9676..10566
                     /locus_tag="ctg437_10"
                     /transl_table=11
                     /translation="MDSVFITTRKQRVIRELRDYMLIALGMLMYAIGWTVFLLPNDLPS
                     GAVPGIASIVYWATGLPVQYTYLGINGVLLILSLVILGWKFSVKTIYAVFVLTSILPII
                     QDLTGGESLIHDQPFMACVLGAFFCGGGIGVAFSANGSTGGTDIIAAIVNKYRDITLGR
                     VILMCDLVIISSSYFVLHDWEKVVYGYVVLFISSFVLDQVVNSARQSVQFFIISKKHEE
                     IGHRINKDLHRGVTFIDGVGCYTGAGVKMMFVLAKKRESTTIFRLIKDIDPNAFVSQSA
                     VIGVFGEGFDRIKVK"
     CDS             10830..12263
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg437_11"
                     /sec_met_domain="Lyase_1 (E-value: 1.3e-91, bitscore:
                     297.1, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 9.4e-26, bitscore:
                     80.0, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKLTEETRVESDLIGAREIPASALYGVQTLRGIENFPISKFHL
                     NEYPLFINGLAITKMAAAMANYELGLLTKEQKDAIVLACQEILNGEHHEQFPVDMIQGG
                     AGTSTNMNANEVIANRALEIMGHKRGEYQYCSPNDHVNCSQSTNDAYPTAIHIGMYYSH
                     LRFLPYLESLIGAFHKKGEEFAHIIKMGRTQLEDAVPMTLGQTFNGFASILRDEIRHLN
                     EAAADFLTVNMGATAIGTGICAEPGYAEKCVEALCEITGFDFKLSSDLVGATSDTSCLV
                     GYASALKRVAVKVNKICNDLRLLASGPRCGLGEFNLPAMQPGSSIMPGKVNPVIPEVMN
                     QICYKVIGNELCVTMAGEAAQMELNAMEPVMAQCCFESVDLMVNGFETLRTRCVEGITA
                     NAERCKIEVHNSIGVVTALNPIIGYKNSTKIAKEALETGRSVYELVLEHGILNKEELDT
                     ILSPENMLKPVKLDIKPRR"
     CDS             complement(12483..12893)
                     /locus_tag="ctg437_12"
                     /transl_table=11
                     /translation="MKQILLFILFMLGISSCDKAPINGKLDGRWQLMTIEYTNGKIEEC
                     NRIYYSIQLHLVEISAKGGNGGTHIGRFSYKGDEVTMSEFRHRGDEEKLTTLNELKPFG
                     LNQAINHLKVEKATGKKLILKSDYARLTFRKF"
     CDS             complement(12922..14409)
                     /locus_tag="ctg437_13"
                     /transl_table=11
                     /translation="MKKIQLFLLLFLLISITQHINAQFPVKTEYTVEMGGTSGKGTYAP
                     MWLTANRQGLSSVNTENGYLRAGIAHTMPLNQHFGFSAGLDLATAYNFTSSFIIQQAYA
                     DLSYRWLNLSIGSKERLPELKNSKLSSGGMVESNNARPIPQVRLEVPYYVAIPGTHKWL
                     YLKGHIAYGRFTDDKWQEHFTSIGNKYAIDVLYHSKSLFAKVGNKEHFPVEFEGGIQMS
                     AQFGGDQYIAGQKEPVIDMPTRFVDFMCVLVPMAGDDTTPEGEQVNIYGNHVGSWNFAA
                     TAYLNQWKVKIYYEHYFDDHSQMFFQYGRWKDGHIGLEITFPKNRFIDTFVYEGLGTKD
                     QTGPMLYDSFWGEFEEQISAKDNYYNHYLYQGWQHWGMGIGNPLLPGPIYNKNGQITFI
                     SNRVLAHHIGFCGSPCQSLSYRMLLSYSRHWGTYDNPLNEIKKQFNSLFEVTYAPQQLK
                     GWSFTVSGAMDRGSMLGNNYGGMLVIRKQGIIKSGNK"
ORIGIN
        1 tctaagaagt ttgctgtgta tgaagatccg cggattgcca aggtgagcga agtgcttcct
       61 caggcgaatt gcggtggatg tggttatccc ggttgctctg gttttgctgg tgcctgcgtg
      121 aaggctgccg atgctggttc gctggagggt aagttatgtc cggttggtgg tgctccggta
      181 atggagaaag tagctgccct tttgggattg gaagccgttg ctgccgaacc gaaagttgcg
      241 gtggtaagat gtaacggtag ttgtgaaaat cgccctcgta ctgctctgta tgacggagct
      301 aaatcgtgtg ccatcgctca tgccacttca ggtggtgaga cgggttgtac attcggttgt
      361 ctgggttgtg gtgattgtgt ggaagtgtgt cagtttgatg ctattcacat gaatcctgaa
      421 accggccttc cggaagtgga cgaagaaaaa tgtacagctt gtggggcttg tagcaaagct
      481 tgtccgcgca agattattga aatccgtccg aaaggaaaga acaaccgccg cgtagtggtg
      541 atgtgtgtga acaaggataa gggagctgtt gccaacaagg cttgcaaggc tagttgtatt
      601 ggttgtggaa agtgtgtgaa agtgtgtcca ttcgaagcca ttacgttaga gaataatttg
      661 gcatacattg atccggctaa gtgtaaatct tgccgtaaat gtgaatcgga atgtccgaaa
      721 ggggctatcc aagctattaa tttcccgcca cgtaaaccga aggtagaagt gccggctggt
      781 gaggctgctg caaaacctgc tgcaaaagta gaggcttcaa aggtggaaac tccggaagcg
      841 gtgaaagctg acgctccgaa agcggaagca taatcaaaat tcaaagtaag taaaaattaa
      901 aaagatataa cagtgaagac atttagaatt ggtggagtac atccagcaga aaataaattg
      961 tcagcaggca aagccattga aacccttgca cttcctaagc aagcggtatt tcctttgtca
     1021 cagcatatcg gtgctcctgc tactgccatc gtgaaaaaag gcgatgtggt gaaggtaggt
     1081 acgaagattg ctgaggcggg tggctttgtt tcagcagcca tcttctcgtc tgtatccggt
     1141 aaagtgaaca aggtagacgc cgtaatcgat gcaagcggtt accgcaagcc ggctatcttt
     1201 atcgatgtgg atggtgacga atgggaagaa tcaatagacc gcagttcgac attggtgaaa
     1261 gagtgtgctc tcacacccga agaaatcgtt gctaaagtga aaaatgcagg tgtagtaggt
     1321 atgggcggtg cttgttttcc tactcatgtg aaactttctc ctcctccggg ctgcaaggcg
     1381 gaatgtgtaa ttatcaatgc tgtagagtgt gagccttacc tcactgccga ccatcgtttg
     1441 atgttggaaa aggcagacga agtactggtg ggtgtaagca tcctgatgaa agctgcaaaa
     1501 gtgaccaagg gatatatcgg tattgaaaat aataaaccgg atgctattaa gttgatgact
     1561 gaaaaagctg ctcaatatcc cggtatagag gtggttccct tgcaggtgaa atatccgcaa
     1621 ggtggtgaga aacaattgat agatgctgtg atcggtcgcc aggttcctgc tcctcccgct
     1681 attcctatca atgtgggtgc ggtagttcag aatgtaggta ctgcatttgc cgtttatgag
     1741 gccgttcaga aaaacaaacc tttgtttgaa cgcattgtaa ccgttacagg taagtctgtc
     1801 agaaatccat ctaattttct cacccgtatg gggactccga tgagccagct gattgatgcg
     1861 gctggcggtt tgcccgaaga tacgggaaaa gtgattggtg gtggtccgat gatgggtaaa
     1921 gcactggtta atacagaagt tcctatttgt aaaggtagtt cgggtgtgct gattatgaat
     1981 gataaggaag ctgcccgtgc ggaagctcag ccctgtatcc gctgtgccaa gtgtgttaac
     2041 gtgtgtccca tgggactgga gcctttctta ttggcaacac tttcagctca taaggattgg
     2101 gagagagtag agaaagaaga tgtaatgtcg tgcatcgagt gcggttcgtg tcagtttaca
     2161 tgtccgtctc atcgttattt gctggactat atccgtttgg gtaagggcac agtaggcggt
     2221 attatccgtg cacgtaatgc taaaaaataa ttcgacaaaa tagtatggct aataaattaa
     2281 tagtatcatt atcgcctcac gttcatagcg gtgacagcat acagaagaat atgtatggtg
     2341 tactcattgc gttgatacct gcgttgctgg tgtcatttta tatgttcgga ctgggcgccg
     2401 tggtggtgac cttgacctcg gttgctgctt gtgtattctt cgaatgggcg attaccaagt
     2461 ttattttgaa gagagaacgc tctaccatct gtgatggttc ggctattata accggtgtgt
     2521 tgctggcatt caatctgcct tccaacttgc cgctttggat tattatcatc ggtgcgttgg
     2581 tggcaatcgg tgtgggcaag atgactttcg gcggattggg ttgtaatcct tttaatcctg
     2641 cgttggtagg tcgtatcttc ttgctgattt cttttcctgt gcagatgact tcatggccgt
     2701 tggttcaaca atggggaagt tataccgatg ctgaaaccgg tgctactccg ctggcattga
     2761 tgaaaatggc tgtaaagggt gatgtaaatg ctttaggtca gttgcccgat acattaagtc
     2821 tgtttctggg taataacccg ggttcgctag gtgaggtgag tgcattggct ttattgcttg
     2881 gcctgggata tatgctatgg aaaaagatta tttcctggca tattcctgta tctattctgg
     2941 tgactgtatt tgtatttgcc ggtctgatgc atttggttga tccggtggct tacgcatctc
     3001 cgttggctca cttgtttaca ggtggtttga tgttgggtgc tattttcatg gcaaccgact
     3061 atgttacttc gcctatgact cataaaggta tgattatata cggtgtggct atcggtttcc
     3121 tgaccgtggt tatccgtttg ttcggtgcat atcccgaagg tatgtctttc gctatattca
     3181 ttatgaacgc attcactccg ttaatcaata cttattgtaa acctaaaaga ttcggggagg
     3241 tcgtgaagaa atgaaaaaac tagaatcatc tttgaaaaac atggttatcg tactgacggc
     3301 gattactgtg attgcaaccg gacttttggc ttatgtcaac caactgactg ccggtcctat
     3361 tgctgaggct aatgcaaaag ctttgagtga cgctattgca gttgtagttc cggggtttga
     3421 taacaatcct gcggaagctc ctgaaactat agaattggat ggtgctactt ataaaatata
     3481 taaggcaacc aagggtggcg aatttattgg tgctgccgta gaatcttctg ccaatggttt
     3541 tggtggcgct ttgagtgtgc tggtaggttt tgacaaagag ggaaatatca tagactattc
     3601 tttgttgagc catgctgaga ctccgggctt ggggtcaaag gcggctgatt ggtttaagaa
     3661 aggtgcaaaa ggcgacatta ccggtatgaa tccgggacag ggagcattgg tggtaaataa
     3721 ggatggtggt cagatagatg ctatcacagc ttctaccatc actacacgtg cttttctaaa
     3781 agctgtgaac aatgcttatg cagcatatag tggtcagaat gtggatggcg ctagtggtgc
     3841 aactcagcaa gtgtctgaaa ctgttgccga aaatgctact gcctgcgatg ctcaatgtga
     3901 aggaaacgag gcatgtaagc aggtttgtga ctctacagcc tgcaagactg tttgtagcga
     3961 taaatgtgat cctgctaact gcgataaggc agactgcaaa aaagtagaat gtcccaagca
     4021 agattgtaaa aataaaaaat aaggaaggag cagactatga ataattttaa agtattgatg
     4081 aacgggattg taaaagagaa tcccacgttt gtactccttt tgggtatgtg tcctacatta
     4141 ggaacaacat cttctgccat caatggtatg gggatgggat tggctacggc ttttgtatta
     4201 atctgttcta atgttgtaat ttcggccatt aagaatttga tacctgatat ggtgcgcatt
     4261 ccggcctttg ttgtggttat tgcatcattc gtaaccttgt tgcagatgat tatgcaggca
     4321 tatgtgccgg cactttatgc tactttgggc ttgttcatcc cattgatcgt agtaaactgt
     4381 attctgctgg gacgtgccga agcttttgca gcaaagaacg gtcccgtgcc ttcattcttc
     4441 gatggactgg gtatggggct cggatttact cttgcattga ctatccttgg tggggtacgt
     4501 gagttcctag gcacaggcaa gttgtttgat atcactatca tgcctgagca atacggaatg
     4561 ttgattttcg ttctcgcacc gggagccttc attgcattgg gataccttat tgcgattgtg
     4621 aataaactga agaaagcata acccgtaaaa agtaagaata tggaatatat attgatattt
     4681 atcaccgcta tatttgtgaa caacattgtg ttgtcacaat tcttgggtat ctgcccgttc
     4741 ctcggtgtat ccaaaaaagt tgagacagct acgggtatgg gtgcggctgt tgcattcgtg
     4801 cttaccatcg ctaccattgt tacctatctt atccagaaat ttgtactcga tgctttcggg
     4861 ttggaatatt tgcagaccat tgcgtttatc cttgtcattg cagcattggt acagatggtg
     4921 gaaatcatat tgaagaaagt gtctcctgcc ctttatcagg cattaggagt attccttccg
     4981 ttgataacca ctaactgctg tattttgggt gtagctatct tggtcattca gaaagatttt
     5041 gatttgttga ctggcgtggt ttacgccttc tctacagctc ttggttttgc tttggctatg
     5101 gtattgtttg caggtatccg tgaacaatta agtttggtga atatacctaa aggaatgcag
     5161 ggaatggcta tcgcattggt tactgccggt ctgctggcaa tggcattcat gggattttca
     5221 ggtgtagaca aaggtttggg ggttctgttt ggaatagaat agttcacttc atcgttaaaa
     5281 taaaccgatt cagaagtccg gagcacagct tcggactttt ttattagaaa gaaatccatt
     5341 gttcttgtcc gtaaattcaa tttttatgct tatttttgca ttagaattaa tagagagatt
     5401 aaatggctat gaccttgatt gtactcgcgg ccactatggg gaataaatat ggtggattga
     5461 aacagctgga gggaataggt cctaatggcg aaacaatatt agatttttcc atatatgatg
     5521 ccgtaagagt cggatttgat aagatcgtat ttgtcataag cagacatttt gaacaagaat
     5581 tcaagaaact ggtatcaggc aaatatgaac atgtggtaga agtggagtat gtttatcagg
     5641 atgtggaaac gattcctgaa gaaaagcgta atccgaaacg caaagcactg tacggctcgg
     5701 taagagctgt tttgatggga gaagagttga ttgactctcc attcggtgtg ataaatgccg
     5761 tgaactttta ccaaagagaa agttttgaat tgttatatga taatctggtg atgttgggag
     5821 aagctgacta ccatagtttc aatatttgct acaggctgag aaatgtattg gcggaaagcg
     5881 gaggggttac ccgtggtatt tgtgaagtgg atgaaaaggg atatctgttg tccgttacag
     5941 accgtgtagg agtagaacgg ataagtggaa atccgatgta tcctaatgaa ttacataaat
     6001 gggtagcttt ggatgacaac agcttggttt caatgaatat gtggggattt actccgcagg
     6061 tatttggtga gatgaagaag gcgttcgata agtttataga tgagaatgga atggatatga
     6121 aagctcatta ttctattccg gcttttatga atgagcgtat tgctgacgga gtcagggtga
     6181 aagtgattga gacacctgcc agatggatgg ggttggtatc gcatgatgac aagatacaag
     6241 tcctgcttcg tatcaatgat atgatacgaa aagggattta cccgtcgaag ttgttttgaa
     6301 cctattagaa aacgacagaa tattaagtat tatgaaagaa agaattttag taacaggagg
     6361 aaccggctac atcggttctc atacggtagt agagctgcaa aatagcggtt acgacgtagt
     6421 gattgtggac aatttgtcca attcaagcgc cgatgtggta gataatatag aaaaggtttc
     6481 aggaatccgt cctgcatttg aaaagttgga ttgcttggat tttgagggaa tggacaagct
     6541 gtttactaaa tatccgggca taaaaggtat tattcatttt gcggctagca aggctgtggg
     6601 tgaatcggta caaaaaccgt tgttgtatta tcgcaataac ttggtttcat tgattaacct
     6661 gttggagtta atgccgaaac atggagtaga aggtattatt ttttcatcat catgtacggt
     6721 gtatggtcag cccgatgttc ttcctgtaac ggaagaggct ccgattaaga aggctgagtc
     6781 tccgtatggt aatacaaaac agatcaatga agaaattatt cgtgatacag ttgcttcggg
     6841 atcgcctatt aatgctatta tgttgcgtta ctttaatcct attggcgcac atcccactgc
     6901 attaataggt gaattaccta atggtgttcc acaaaacttg ttaccctacg ttactcagac
     6961 agcaatgggt attcgtgaaa aactgagtgt gtttggggat gattatgata caccggacgg
     7021 ttcttgcatc cgtgactata tatatgtagt ggatttggcg aaggctcacg ttatcgcaat
     7081 ggatcgcatt ttgaataaca agcagaagga gaaggtggaa gtctttaata ttggaacggg
     7141 taaaggcgtt tctgtattgg aactgatcaa tacatttgaa aaagctaccg gtgtgaaact
     7201 taattatcag atcgtgggtc gtcgtgccgg agatattgag aaggtatggg ctaatcctga
     7261 cttcgctaat aaggagttgg gatggaaggc agaagccaat ttggaggaca cgctacgttc
     7321 ggcttggaac tggcagttga agctaagaga aagaggaatt caataagaat taagatattt
     7381 ttagaaagac cgatgaacaa aggacgctag tgtggcgttt tatagatgca aataacctga
     7441 aacccctctt ggatatgtga atacctgatt ggcggtagtt atgttactca aaacatagag
     7501 caggctaaaa aattgcatag tagttttgtc gtgttttatt ttgtgtttgt gttgtggctg
     7561 ttctccgacg tgagtcgggg gacagttttt tttgactatt tagttgtttt ttagttattt
     7621 atggctatat ttgtcgaaaa taatcacgca ctactttatg aaaacaaaat tttggatcat
     7681 ctgcttatca gttttctttg tgtcttgctt gcgtaatatg catgatatat acacgggggg
     7741 aggggaagaa gaggaggaaa aaatcaataa agacgatttt tttgatttta ctactgtccg
     7801 taatagtcaa cttattattg attatggtat gaaagtacag actgcttttt atctgtatga
     7861 tgaatatcct atggaattag ttgaaaatac ttgggagttt aaagatataa atcccattta
     7921 tgctgcttcg actgatatga atggtagatt tttttcaaaa gtatctttgc cggcttattt
     7981 gaaaaaggta tggctggtaa ctgataatgt gttggtcgta tcacctgttg aattggaatt
     8041 actatctgac ggactaacct ttaattatgt tgattataag gcacaactgt ctgccgatgg
     8101 gcgttctaga gcagtaatgg gaggagtgag ttatcctgac ggatatgatg tattgggtaa
     8161 ttggaatgaa aatggggttc ctgattattt gttgcctgaa aagttggata tacctggtgc
     8221 ttttttagag agatgcagta atttaagccg ttctatagta gtagataatc gtaatttgtt
     8281 ggaaagattt ccggaactgc gtacttcagg gagtaatgat atggtaataa ctaaatctac
     8341 aggtttggta gcgacttatt ttaatttctc gtctactacg tgggaggata tggttgctta
     8401 ttatacttat aaagaaggag agtccgtgga catggctacc ataaaaaaga ccatcctgat
     8461 tcctcgttcc agtaggaatg ctcctaaatc tttagtcggt gagcaaataa aactaaaata
     8521 ttggaataag gaacaaagca agtatgaaga tgaattcccc caaggcactc atattggatg
     8581 gattttattg ggaatgggat ttggaaaaga aaagggtgtt tttcctcgtt attctaatcc
     8641 tgcatataac gataataaag agcaacgttc agttttgtta agtgatccgg aactggacaa
     8701 ttgtttcttt atggctatgg aagataatgt ggacatgcgt tttaatgatg tacagtttgc
     8761 tattatggca tctgcttctt cttctgtaga acctactcct aatataccgg atgaagtaaa
     8821 taagggtgaa atttcgtatg tagtcaaagg gtctttggct tatgaggaca attggcctga
     8881 taagaatgat tatgatatga atgatgttgt gatatattat tccagtacag ttgtaaaaga
     8941 taaatcttct aacgcattgg tgcgcaccac tactactttt actccgatga atgatggtgc
     9001 tacttataca aatgggtttg gtttccagtt ggattacgta gggaaggagc atattgattt
     9061 ggtgcaggtg agtcaagaag gtaatgtgat cggaaaaaac tttgagccgg gaatagaaaa
     9121 gcctgtatta atactttttt ctgatataaa gcctgttctc aaaaagcctg tgactgtagt
     9181 gatcggattt aaaaaatatg ataaagtaag cgatatggat gcttatccgc cttacaattc
     9241 tttcattttt gtgaataaac gttctcatga agtacatttg tcaggctata agccgacaag
     9301 cgtagctgat gagagtttac gtggtacggg tagtgatttg agtcaagatt ccaatggtac
     9361 cccaatgtat tatatagcag aagataatat gcctttcgct ataaatatca gtaacagtga
     9421 atttagatgg ccttcagaga aggtgtctat taccacctat tatcccgagt ttaaacagtg
     9481 gagagattct tttggtgcgg attataaaga ttggtattta caccccaaag aataataaag
     9541 ggtgaaaagt actgttgttt ttgataaatc agattaacag gactttttac ttgaaaaaat
     9601 gtcacctttt gaagccaagt gattcaatct ttttgtactt ttgcggacaa tatgatttta
     9661 taaaggaaaa ctcacatgga ttcagtcttt attacgacgc gtaagcaacg ggttatcaga
     9721 gaactaaggg attatatgtt gattgctctt ggtatgctga tgtatgctat cggatggacc
     9781 gtctttttgt tacctaatga ccttccttca ggtgcggtgc caggtattgc ttctattgtt
     9841 tattgggcta ccggtttgcc ggtccagtac acctatttgg gaataaacgg agtattgttg
     9901 atactttctt tggttatttt gggatggaag tttagtgtga aaaccatcta tgctgtattt
     9961 gtgctgactt ctattctgcc tatcatacag gatttgacag ggggagagtc tttaatacat
    10021 gatcaacctt tcatggcttg tgtcttggga gcctttttct gcggaggtgg tattggtgtc
    10081 gctttttctg ccaatggtag cacaggaggt acggatatta tagctgctat tgtcaataag
    10141 tatcgtgata ttactttggg ccgggttatt ttgatgtgtg atttggttat tatctcttcc
    10201 agttattttg tattgcatga ttgggagaag gtggtatatg gatatgttgt cttgtttata
    10261 tccagctttg tcttggatca ggtggtaaat agtgctcgtc agtcagtgca attctttatc
    10321 atttcgaaga agcatgaaga aatagggcat cgcataaata aagatcttca tcgaggggtg
    10381 acgttcattg acggagtagg ttgttatacc ggtgcgggtg tgaaaatgat gtttgtgctg
    10441 gcaaaaaaac gtgagtctac tactatattc cgtttgataa aagatatcga tccgaacgca
    10501 tttgtatcac aaagtgctgt cattggtgta tttggagaag gctttgatag aataaaggtg
    10561 aaataagagt tccgaagtta aaaaatagaa taagggcgtt ctgaatggac gccttttttt
    10621 atgtctgttt tttgaatgaa cttcaaagga tataagactt tgttaactga gtaaactttc
    10681 ataatgtaag tttgttgtct gttttgcagc aataaacatg tataaaataa tattttaaaa
    10741 ttatatcaga ttatattttg atatcaaaat gttagtttat acctttgcta tataaaataa
    10801 gaaatgataa actaataaat aacctgatca tggaaacaaa acttacagaa gaaacccgag
    10861 tagaaagtga tttaattggt gcccgcgaaa ttccggccag tgcattgtat ggtgtgcaaa
    10921 ctctaagagg catagaaaat ttcccaatta gtaaatttca tctaaatgaa tatccgttgt
    10981 ttattaacgg tcttgccatt acgaaaatgg cagctgcaat ggctaactat gagttaggtt
    11041 tattaactaa agaacaaaaa gatgccatag tattggcgtg tcaggaaatc ttaaatggtg
    11101 agcatcatga gcaattcccg gtggatatga ttcagggagg tgccggtact tctaccaata
    11161 tgaatgctaa tgaagtcatt gctaaccgtg ctttggagat tatgggacac aaacgtggcg
    11221 agtatcaata ttgctctcct aatgaccatg tgaactgctc acaatcaacg aatgatgctt
    11281 atcccactgc aatccatatt ggtatgtatt attctcatct tcgttttctt ccttatttgg
    11341 aatcgctgat tggtgcattc cataagaaag gagaggagtt tgcacatatc atcaaaatgg
    11401 ggcgtactca gttggaagat gccgtaccta tgactttagg tcagacattc aatggttttg
    11461 ccagtatatt gagagacgaa attcgtcatt tgaatgaagc ggcggcagac ttcctgacag
    11521 taaatatggg tgctaccgct attggtacag gcatttgtgc ggaaccggga tatgcagaaa
    11581 aatgtgtgga agcattgtgt gaaattacag gttttgattt caaattgtcg tcagatttgg
    11641 taggagctac ttcagatact tcctgcttgg taggttatgc ttcagcttta aaaagggtag
    11701 ccgtaaaagt aaataaaata tgtaatgatt tacgtttgct ggccagtgga ccgcgttgtg
    11761 gtttaggaga attcaacctt ccggctatgc aaccgggatc ttctataatg ccaggtaagg
    11821 tgaatccggt gattcctgaa gtgatgaatc agatttgtta taaagtaata ggtaacgaac
    11881 tatgcgtgac tatggctggc gaagctgctc aaatggaact gaatgctatg gaaccggtga
    11941 tggcacagtg ttgttttgaa tctgtagatt taatggtcaa tggttttgaa accctgcgta
    12001 cacgttgtgt agaaggtatt actgctaatg cggaacgctg caagattgaa gtgcataaca
    12061 gtattggtgt agtaaccgca ttgaatccga ttattggtta taaaaattct acaaagattg
    12121 caaaagaagc gttggaaaca ggtagaagtg tctatgaact ggtcttggaa catggtattt
    12181 taaataagga agagttggat acaattctaa gtccggagaa catgttgaaa ccggtaaaat
    12241 tggatattaa gcctagaaga taaatttatt tcaccacaga ctacaggaaa gtaaagaact
    12301 tgttttatga agccggcttc aatatttgta aagccggctc catgagtggt ggcactagtt
    12361 ttattcctgc cgataaatta atttctagaa atccggcata gtgttttgtc accgctatag
    12421 cgtataaatt gttttttcat attttatcag cagatagttt gcgtagtctg tggtatactt
    12481 ttttagaact ttctgaatgt gaggcgtgca taatcagatt tcagaattag tttcttgcct
    12541 gttgcttttt ccactttaag atgattaata gcttgattaa gtccgaaagg tttcaattca
    12601 ttcagtgtcg ttagtttttc ttcatctccc cggtggcgga attcactcat ggttacctca
    12661 tctcctttat aagagaaacg tccgatatga gtgcctccat ttccaccttt ggcactgatt
    12721 tccaccaaat gtaactggat actataataa atgcggttac attcttctat ttttccatta
    12781 gtatattcta tagtcattaa ttgccatctg ccatctaatt tgccattgat gggagctttg
    12841 tcacaactgc tgattcccag cataaagagt atgaataata atatttgttt catatgttga
    12901 ttgggttgac agttaaaact tttatttatt gcctgatttg ataattcctt gtttgcggat
    12961 aaccagcatt ccaccataat tatttccaag catgctgccg cgatccatag ctccggatac
    13021 agtgaaactc catcctttca gttgttgtgg agcataagtt acttcaaaca aagagttgaa
    13081 ttgtttcttt atttcattca gaggattatc ataagtaccc caatgacggg agtaggagag
    13141 tagcatacga taactcagcg attggcaggg ggaaccgcag aatcctatgt gatgtgccag
    13201 tacacggttg ctgataaaag taatctgtcc attcttgttg taaataggtc cgggaagtag
    13261 aggattgcct attcccattc cccaatgctg ccatccttga tagaggtaat gattgtaata
    13321 attatcttta gcactgattt gctcttcaaa ctccccccaa aaggaatcat acagcatagg
    13381 tccggtttga tcctttgttc ctaatccttc gtatacaaaa gtatcaatga agcggttttt
    13441 tggaaaagtt atttccagtc cgatgtgtcc gtctttccag cgtccgtatt ggaaaaacat
    13501 ttgggagtga tcgtcgaaat aatgttcata atagattttt accttccact ggttaagata
    13561 agctgttgcg gcaaaattcc aactaccgac atggtttccg tagatgttta cttgttcgcc
    13621 ttcgggtgtg gtatcatctc cagccatagg aaccaatacg cacataaagt caacaaaccg
    13681 ggtaggcata tctattacag gctctttttg tcctgcaata tattggtctc cgccgaattg
    13741 agcggacatt tgtattcctc cttcaaattc taccggaaaa tgttctttgt ttcctacttt
    13801 ggcgaaaagc gatttactgt ggtaaagtac atcaatggca tatttgttac ctatggaagt
    13861 gaaatgttcc tgccatttgt catcagtaaa acgtccatag gctatgtgtc ctttcaaata
    13921 aagccattta tgggtacctg gtatggctac ataataggga acttccaagc gtacttgggg
    13981 aatggggcgg gcattatttg attctaccat gcctccactg cttaacttgg aattctttaa
    14041 ttcgggcaag cgttctttac tgccgatgct caggttcaac catcggtagc taaggtctgc
    14101 ataggcctgt tggatgatga atgaggaggt gaaattgtag gcggttgcca aatccagtcc
    14161 tgcactgaag ccgaaatgtt ggtttaatgg cattgtgtgt gcaattcctg cccgtaaata
    14221 accattttca gtattgacag aagataaacc ttgcctattg gcagtaagcc acataggtgc
    14281 gtaagttcct ttacccgatg ttcctcccat ctcaacggta tattctgttt tgacagggaa
    14341 ttgggcattg atgtgctgcg taatggatat taacagaaat agtaataaga atagttgtat
    14401 tttcttcatt tagtttatgt gttttggttt agtgtaaagt ttgctaaaac gaagcagatt
    14461 tatcagtctg ccatcctgaa cttttgtgaa agatttggtt tctaatcact ttatgtatat
    14521 gaaaagcttc actaatgccc agaatggcaa actatataat catatcagca aaagttttgg
    14581 catatttatt ttcctccggc aggcaggttt ttcaaccagt aatcagccat tgtctttcgc
    14641 agatgcaagc tggttccctc gccttcataa attccatggg aacgcatagg gtaagaaatc
    14701 tgtgagaaga tctttccgtg ccgtaccagt tcattgacca acatttcaca attctggtaa
    14761 tggacattat catctcctgt accgtgaatt aacagcaagt tgcctttcaa tcctgctgca
    14821 tacgagatgg gagacccttt gcggtaaccc tccggattat tttgaggggt gttcatgtaa
    14881 cgttcttgat aaatcgtgtc atacagacgc tggtctgcta caaaagcaat ggcaatgcct
    14941 gtgtggaaaa catcgggata acggaacata ctattcagag tctggctgcc tccaccactc
    15001 cagccggtga taccgatacg tgtggtgtca atgaaagagt attgacgtgc caagtcttgg
    15061 atgcctcttg cctgatcttc actggcaaag gttccgactt ctccataaat acatttgcgc
    15121 cattcgcgtc cacggggtgc attggcacca cggttctcga tgctgactat gatatacccc
    15181 aggtttgcca agtattggtg ccataaactt tctccgctcc atacatcctg tacagtggcg
    15241 ttggcaggtt ctccatagac at
//
