LOCUS       c00053_gnlPro..        13417 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FGBJACCP_53.
ACCESSION   c00053_gnlPro..
VERSION     c00053_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:40:58
            Original ID  :: gnl|Prokka|FGBJACCP_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13417
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13417
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[189:3417]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      190..3417
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13417
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13417
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             190..1812
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-43, bitscore:
                     137.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHTNEEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             1825..2316
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_2"
                     /sec_met_domain="ALS_ss_C (E-value: 6.7e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             2377..3417
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="IlvN (E-value: 1.3e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.6e-61, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYEGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(3972..5810)
                     /locus_tag="ctg53_4"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVAVSAVSANAVEPLNTPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYVDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGTAVKYIAAPEISKLENVNGGVKISWGKVSGATKYRV
                     YYKGSKGWTRMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVA
                     TPKISKLEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFD
                     LSIDDIYYTVRCISKDAKSFTSGYDSKGTPIGDHQDCPEIYSIGAVNNGVEMHWTGDAP
                     KFRVYIKENGSWKKIAETYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYR
                     YKTSDKTRDAYINYMMNHQSEWMPSLGSEHNLSGVMFLDFDFDGVPELVAQKADSNEYS
                     FHSVVYKFEDGKLKRVGNVNDGFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITY
                     DGENLFANMYSARGVGEESNNNIYYRYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTE
                     FIATGYGDASVWGEKTTAENKQSLLDAYNSFSYEKY"
     CDS             complement(6007..6684)
                     /locus_tag="ctg53_5"
                     /transl_table=11
                     /translation="MKKFLTALIAFVMCFSVVTTAFAATPDEISESDVASEIRQVMIDT
                     YYGGKEPEYLSIEIVGSTSDGGVYFMHNEGFSLDYSIEEIIGDYTYHYNHNDDVMLYKN
                     GNVYSIKEAYESGVIDDSILEELSKMNFGLESNKPNTTVPTEPTTSVATVDEPVTVPDT
                     TSATSATKPVSTSNTATKDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRN
                     YFK"
     CDS             complement(6880..8283)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_6"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 2.9e-55, bitscore:
                     177.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPAFQKKIIGDKKI
                     IKGRPADQLEPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             complement(8314..8679)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.7e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPATAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             complement(8718..10052)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Btheta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_8"
                     /sec_met_domain="CT_Btheta (E-value: 1.5e-67, bitscore:
                     218.6, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLEDFKMSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFA
                     KSGEGFAEVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVG
                     FYDSVGGRLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIM
                     SKDAQLSLSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSF
                     EEAPAEDGCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGKELGCKS
                     ANKVAKFVRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSG
                     YVALAGTGANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLS
                     AYNAAQNGYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             complement(10262..11011)
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVRVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             complement(11055..12179)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_10"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.9e-58, bitscore:
                     188.1, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIISLAVCFVMPFVLMGAKTAEDTPPTTSAQAFVLYCPDNNTV
                     ICSKNADEKMKPASTTKIMTSLITLEEAASCNSEVTFKQEMVAEGSSMYLKVGEKVRLS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMTNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENDDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLLLYPYCTGGK
                     TGYTTVAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKDSVTVTGEKNSTIVLKREDCDKIKKKIFIDRFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGEKIKSDKKSVSIFSAIGNLFS"
     CDS             complement(12231..12614)
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MEKIKEMIDVNTIIGEPITSPDGTLIIPVSKVSYGFAAGGSDLPT
                     KKENKDCFGGGSGAGVTIQPVAFLTVYQGDVRLVSVDREEGTADKLVSMIPDVLKKVKG
                     VFKKDKSESADDFSEITQDDIDG"
     CDS             complement(12681..13301)
                     /locus_tag="ctg53_12"
                     /transl_table=11
                     /translation="LLWLYILLGIVLFIALVMFIPITLRASYKEKFWCAVYIGFVKLQL
                     VPAKPKKEKKKKKAKKQTQKTEQPKKATEKKLSLIKKYGIEWLLNLIKKVAELAVSALQ
                     DFFSHISVKKFSLSISVAGDDAADTAIKYGKYCAVVYPAVGTIVRVVKCKGYGVDINPN
                     FSEKAETEINFDFAAKIFAFRLIGLAVKHGIKGIKLLAEVKND"
ORIGIN
        1 gtaaaaatca attaaaatca attttgcaaa ttatctgtca aaatcctgca aaaaatttaa
       61 tttatgggca atactgctct ttacttttta aggtatttat tgtataatta gcggtaaagt
      121 aaaaaggtat atttaatgtt acaaaacacc ttttgctcac aataaaaagg ataggaggga
      181 caaaacataa tgatcagcgg tgctgaaatt atggtaaaat gtttggaagc cgagggcgtt
      241 gacatagtct ttggttatcc cggtgcggct atttgcccat tttacgataa agtttacgat
      301 tcgagcatta cccacattct tgttcgtcag gaacagaacg ctgctcatgc ggcaagcggc
      361 tatgcaagat gcagtaatcg tcccggtgtt tgcgtggcaa cttccggtcc cggtgcaacc
      421 aacctcatca caggcattgc aaccgcctat acggactcta ttccgattgt tgccattaca
      481 ggtcaggttc gttccgacct tctcggcaga gatgtctttc aggaagctga catcacagga
      541 gcttgtgaac cgtttgtaaa gcacagttat ctcgtcagca aaacagaaga ccttccgaga
      601 gttttcaaag aggctttcca tattgcctca accggcagac ccggtcctgt acttatcgac
      661 attcccgttg atattcagga aaatgaaatt gaaagttttg aatatcccga aagcgtaaac
      721 attatcggtt acaagccgaa cactaaggga cacgcaattc aggttaaaaa ggctgttgag
      781 gccatcaacg caagcaagcg tcctgttatc gtatcaggcg gcggcgtgct gagttcgggt
      841 atcaagctta aacttcaaaa atttgcagaa actacgggta tccccgttat ttcaactatg
      901 atgggcatcg gtgttatgcc cagcgagcat gagctttatc tcggaatgct cggcactcac
      961 ggcaaggctg ttgccaaccg tgctcttcac gaagccgacc ttgtaatcgt atgcggtgca
     1021 agactcggtg acagagctgt tgcggctccc gaccagatga gtgaaaacac aaaggtaatt
     1081 cacattgaca ttgaccctgc tgaaatcggt aagaatgtta aaacagaaat tccgattgta
     1141 ggcgatatga aaaatgtcat caatatgctg cttgacagta tcggcgatta caaggttaca
     1201 acaatgtgga gcgaaaccgt aaagaactgg aaaaaagacc tttaccgtga gcctcccgta
     1261 tttgacggct ttgttgagcc gagaacactt gtcggtcatc tcagcgcaat gttccgctcg
     1321 aaggcaattc ttgttgccga tgtaggacaa aatcaaatct ggtgtgcaaa caacttccgt
     1381 attcgtgagg gcagattcct cacaacaggc ggtatgggta caatgggtta ctcaattccc
     1441 gctgcaatcg gtgcaaagtt tgcaagaccc gaccgtgacg ttattgtaat ctgcggtgac
     1501 ggcagttttc agatggggct taatgagctt gcgactattg caggcaatca gctcggaatt
     1561 aaaatcatca ttatgaaaaa cgcacgactc ggaatggttc gtgaacttca ggacaaacac
     1621 tacggtggca gacactccgc aacaattctc aacggtgatc ccgacttctt gaagattgcc
     1681 gatgcttacg gcattgacca tgcagaggct catacaaacg aggaagccga aaacatcatc
     1741 aagggtattg ttgattcgga aaaaccgttc attcttgttt gcgatgttca ccccgacact
     1801 ccgtcaattt aatgaggtga taaaatgcag tatacattat caatacttgt tgaaaatcag
     1861 gcgggcgttc tttcaaagat ttcgggactt ttctctcgcc gaggctttaa catcgactcg
     1921 cttgcagtag gtgttactca ggacccgtcg gtttcccgaa tcacaatcgt tgcaaacggt
     1981 gacgagtaca ttgttgaaca gcttgaaaaa cagctcaaca agctcattcc cgttattaag
     2041 gtaaaaaggc ttaacgaggg cgaatttatc agccgtgagc ttgttttaat caaggttcac
     2101 tgcgccgcct caaaaagagc cgaaattgtc aaaacggttg aaattatgca ggcgaaaatc
     2161 gttgatgtat ccccttcgtc agttaccgtt gagtactgcg aatgcgcaag ccgcgtcaac
     2221 acgcttgttg acttactcaa gccttatggt atccgtgaga ttgtaagaac aggtactgtt
     2281 gccattgaca gaggcacagc ttcggtttcc gtttaatctt acagttagca tatattctaa
     2341 tttatatgcc gcgtttgcgg taaggaggac tttaatatga aagactacac aaagaacatg
     2401 acagcaccaa tctactatca gtcagattgc aaccttgacc ttctcaaggg taagaaaatt
     2461 gctattatcg gttacggcag ccagggtcat gcacacgctc tcaacctcaa ggattcaggt
     2521 tgcgatgtaa tcatcggtct ttacgaaggt agcaagagct gggcaaaggc tgaagctcag
     2581 ggctttaagg tatatacatc ggcagaggct gcaaagcagg ctgacatcat catgattctt
     2641 atcaacgatg aaaagcaggc agctctttac aagaacgaca tcgagccaaa cctcgaagca
     2701 ggcaatatgc ttatgttcgc tcacggcttt aacattcact tcggttgcat caagcctcca
     2761 aaggatgttg atgttacaat ggtagctcct aagggacctg gtcacacagt tcgttcagag
     2821 tatcaggttg gtaagggtgt accttgcctc gttgctgttg agcaggacgc tacaggtcag
     2881 gctaaggatc tcgcacttgc atatgcactc ggtatcggcg gtgcaagagc cggcgttctt
     2941 gaaacaacat tcagaacaga aacagaaaca gacctcttcg gtgaacaggc tgttctttgc
     3001 ggcggtgttt gtgcacttat gcaggcaggt tttgaaacac tttgcgatgc cggttacgac
     3061 ccaagaaatg cttactttga gtgtatccat gagatgaagc tcatcgttga ccttatctat
     3121 cagtcaggtt ttgcaggcat gagatattca atctctaaca cagctgagta cggtgactac
     3181 atcacaggtc caaagatcat cacagaggat actaagaagg ctatgagaaa ggttctttct
     3241 gacattcagg acggtacatt tgctaaggac ttcctccttg acatgagcga tgcaggttca
     3301 caggttcact tcaaggctat gagaaagctc gctgctgaag ctcctgccga agtattcggt
     3361 aaggaagtta gaaagctcta cagctggtct gacgaggata agctcatcaa caactaatgt
     3421 tttttagttc gtgaagacag tttgatatat tcaaacttcg gtcacccgaa cattacatag
     3481 tataaattaa cggttcagtc aatttggctg aaccgttttt tgtaggggcg cactgtattc
     3541 gtcggcaagt aaaggcataa attcgatacc aaatccaatt atataaaaat cacaaattta
     3601 ctgataatcc gtagcggcga acctcgttcg ccaatcgaac cgattgtaaa atcggttcga
     3661 ctcaacacaa actattcgtt tattaatata tcattttcat ataacaaaag ctgtgtatat
     3721 gttcggtttg tttttgcaaa caaaccgatt ggcgaacacg gttcgccgct acagtagaac
     3781 aatcacattg cgacatttat aaaattacat ttgtaaattg ttttgtgcca ttacttgcgg
     3841 gcgggtaata atctcccgtc tgaaatttat aattttccac tttctgcttt tcattttcca
     3901 tttaaaaaat cagggttcag ctttttacgg ctgaaccctt ttgcagttaa aacttatcaa
     3961 tttttaaata atcaatactt ctcataggag aaagaattat atgcgtcaag caaagactgc
     4021 ttattctcag cggtagtttt ctcaccccat acgctggcat caccataacc tgtcgcaata
     4081 aattcggtaa acatatgtgc atttacgcaa ttattaaact gtttaaggtt aatttcgtta
     4141 tattttgccc gtgaaatatt tttgtcatta ccgtcaaaat atctataata aatattatta
     4201 tttgattctt cgcctacgcc tcttgccgaa tacatatttg caaaaagatt ctctccgtcg
     4261 tatgtgatta ttgaattacc cgaccaatag taaccgtcat ctacatttaa agatatcttt
     4321 aggtcgtgaa cctcatactt tttggcagtt ttattatagt atatcgcaaa accgtcgtta
     4381 acatttccca ctctttttaa cttaccgtct tcaaatttgt aaacaacgga atggaaacta
     4441 tactcattgg aatcagcctt ttgtgcaaca agctccggaa ctccgtcaaa gtcgaaatcc
     4501 aaaaacataa cacctgacaa attgtgttca cttcccaagc ttggcatcca ttcactctga
     4561 tgattcatca tataattgat ataagcatcc cttgttttat cggatgtctt atatctgtat
     4621 gttacaccgg ttgggttaaa catcgtagta aactttttac cgtcttttga aacacctctt
     4681 accgtataag tgttactgcc ggactttgca cccttgtgaa cataatagtt gtcataagtt
     4741 tctgctatct tcttccaaga accgttttct ttaatataaa cacggaactt tggcgcatct
     4801 cccgtccaat gcatttcaac accgttgttt actgcaccaa tgctgtaaat ttcgggacaa
     4861 tcctgatgat cgccaatggg cgtacccttt gaatcgtagc cgcttgtaaa actcttggca
     4921 tccttgctga tacaacgaac cgtgtaataa atatcatcaa tgcttaaatc aaattccttt
     4981 gaaacaacat tcatatcaag catagtcgtg cctgttgtat cggcaagctt tgtccaaccg
     5041 tttctgtcct tgtagtacac acgatatttt tcagcacctg cgaccttgtt ccatgtcagc
     5101 tttacaccgt catatgtaac ctcaagtttt gaaattttcg gtgtggcaac atactttacc
     5161 gacttgcctg tcgggttata accgcttgtg aatttctttg cgtctgatgt aatacatctt
     5221 acagtataag tgtaatttct gcccgatgaa acatccttgt cgatatatga ggttgaagtt
     5281 gtatcgacca ttcgtgtcca gcctttactg cctttgtagt aaactctgta tttagttgca
     5341 ccgcttactt tgccccaaga gatttttaca ccgccgttta cattttcaag ctttgaaatt
     5401 tcgggggcgg caatatattt tacggctgtt ccctttgaat cataaccgct tgtaaagctc
     5461 tttccgtcag cagaaataca tcttacagta taggtgtaat tcctgcccga tgaaacatcc
     5521 ttgtcgacat atgaggttga agttgtatca accattcgtg tccaaccttt acggcccttg
     5581 tagtaaactc tgtatttagc cgcaccgttc actttgttcc atgtaagctt tacaccaccg
     5641 taaacacttt cggcttttga aattttcggt gttgccaagc ttgcccttgc aacctgtgca
     5701 tactgcacag gtgtgtttag cggttcaacc gcatttgcag aaactgccga aaccgcaacc
     5761 gcagacatcg acattaccgc cgccatggct ataggtaaaa actttttcat atctatccct
     5821 cgctttgtaa atattctacg cattattaag aacttttgct aaatttttat gcaagttaat
     5881 tgtaacatta aatgatataa aaagcaatac atcttgataa actatcacaa atttttaagc
     5941 taaaataaat aaaccgttca caaaagcgag aacggtttat tttatatatt ctgttgatgt
     6001 tttgaattat ttaaaataat ttctgcgttt tgcaaaaatt actgcacaac ctgcaagcat
     6061 tgcaacaaga agaattacag caacgctgtt ctgtcctgtc tgtacagcac cgctgttatt
     6121 ctgtgaattg ttcggtgtgt cctttgtagc tgtgttgctt gttgaaacag gcttagttgc
     6181 cgaagttgca gaagttgtat cgggtactgt tacaggttcg tcaactgttg caaccgaagt
     6241 tgtaggctca gtaggaacag ttgtattcgg tttattagat tccaaaccaa aattcatttt
     6301 tgacaattct tcaagaatac tatcatcaat aactccgctt tcataagcct ctttaattga
     6361 gtaaacattg ccattcttat aaagcataac atcatcgtta tggttgtaat gataagtata
     6421 gtcaccaatt atttcttcaa ttgaataatc aaggctaaag ccttcattgt gcataaaata
     6481 tactccgccg tcacttgttg aaccaacaat ttcaatgctg agatattcag gctctttacc
     6541 accgtaatat gtatctatca tcacctgtct gatttctgat gcaacatccg attctgatat
     6601 ttcgtcaggt gtagccgcaa aagctgttgt tacaaccgaa aagcacatta caaatgctat
     6661 caatgctgtt aaaaattttt tcatttttat ttcctcacct tttatttatt ctatctgtaa
     6721 taatggtata cgcaacagat atttaattta ctttattata ccactaaaat atatgtaatg
     6781 caatatagtt gatgaaaatt cagcaaaaaa aattctgttc aaataaaaat gccacttcca
     6841 tagttgaaag tggcataaat gttaatttta gttgtcaaat caaacagggt gaaccatatt
     6901 tttcttgtca agcttgtcgc cgttgatgcc aaccttggca tttcttctct tttcaaagaa
     6961 gtcgagagca accttcggga actgtgcata agaaagaaca tcctcaggct gttcaatcca
     7021 ctgctcaatc tcgccacgga gcttatcaag ctcaggctca agctgatctg caggacggcc
     7081 tttgataatc ttcttgtcac cgataatctt cttctgaaac gcaggatcaa tcggcattgg
     7141 agttgtaccg tactcaccgg caacaagtcc cttgaactcg tttgtgcaca ttgagtagcg
     7201 cttgcctgtg attacattga atacagcctg tgtgccgaca atctgtgatg tcggagtaac
     7261 aagcggagga taacctgaat ccttacgaac acggggtact tctgcaagaa cttcgtcaag
     7321 cttgtcttct ttaccggcct gcttgagctg tgaaagaagg ttggaaagca taccgccggg
     7381 aacctgatag ataagagcgt tagcgtctgt tgcgagcatc ttaggatcaa gaagtcctga
     7441 cttgatgtac ttctcacgaa gagtcatgaa gtaagcacgg atgtcagaga actgtttaag
     7501 gtcaagacct gtgtcgaact ctgtgcctga aagagcggca accattgact ctgtaggtgc
     7561 gtgtgatgta ccgagagcga gtggactgat tgctgtgtca atgccgtcgg cacctgcctc
     7621 aacacccttt aaaagacaca ttgatgcaag acctgatgtg tagtgggtgt ggagctgaag
     7681 cggaagctcc ggaacagcgg ctttgatagc ctttacaagg ctttcggttc ttgtcggagt
     7741 aagaagtgca gccatatcct tgatacagat tgaatctgca cctgcgtctg caattctctt
     7801 agcatactca acatagtatt catctgtgaa tacaggacct gttgtgtagc tgatagcaac
     7861 ctgtgcatga ccgccttctt tgttagcggc cttgatagct gttttaagat tcttgatgtc
     7921 gttaagagca tcaaaaatac ggataatgtc aataccgttt gcgattgaac gctgaacaag
     7981 gtactcaacg cagtcatcgg catagtgacg ataaccgagc atattctgtc ctctgaaaag
     8041 catctggagc tttgtgttag ggcaatgctc tctgattgtg cggagtctgt cccacggatc
     8101 ttcgtttaag aatctgaggc atgagtcata tgttgcaccg ccccagcatt cgagtgagta
     8161 ataaccgatt ttatcgagtt tgtcaagaac agggagcatt tcctctgttg tcattcttgt
     8221 tgcaatgagt gactgatgag cgtcacgcag agcagtttcg gtaactctga ttttttttgc
     8281 cattttacag catccctttc tccgaattat tgattagtta agtgttacga gaaccttacc
     8341 ggagtcaaca gactcaccct ttgcaacatc aactgttgca actgtgccgt cctgcggagc
     8401 cttaacggga gtttccatct tcatagcctc gataaatacg aggtcatctc cagccttaac
     8461 agcctgtcct gccgaaacaa caacattaac aactgtaccc ggcataggag cctttacaac
     8521 aacggaaccc tgagcgcctg cgggagctgc cggctttgcg gcaggagcgg gagcggttgc
     8581 cggagcagga gctgctgctg cgggagctga agaaccaccg agttcttcaa cctgaacatc
     8641 atatgctgtg ccgttaactg taattcttaa attcttcatt tttagtatcc ccttttattt
     8701 taacaagtaa tcatttatca gatagttgaa tgcttctttg aaagtgttga aacacgcttg
     8761 cccgagagca tatcaagagc agaaataaga gtctgacgga gctgagcttc ttcaacaata
     8821 ccgtcaacat agccgttctg agcggcattg taagcagaaa gattctcgtc agcaaacttc
     8881 tgagcaacct cagcctgctt atctgtggca acattcataa cttcgggagc cataatgaat
     8941 gcggcagcct caacattaac aggtgaaata accgcatcgg gaagtgcgta aacaacatct
     9001 gcattagcgc ctgtgcctgc aagagcaaca tagcctgaac cgattgcctt gcctgtaaca
     9061 acagaaatct tgactgttgt tgcctcagca taagcggctg atgcctttgt tgccgacttg
     9121 attgactcaa agcccgggca gtttacgaat gttacaacag ggagtgagaa agcgtcgcag
     9181 aaacgaacaa actttgctac cttgtttgca gacttgcaac caagctcctt gccctttgta
     9241 acaacaatac ctacaacctg accgccgagt cttgcaaaac gaacatttgc ttccttgccg
     9301 taatcattga agagctttac aatgctattg ccgtcaactg ttctgctgac tacacaaccg
     9361 caaccgtcct ctgccggagc ttcttcaaat gactgaggag ccattgtgag gttatttgac
     9421 ggaagataaa ggataagttc ctttgcagcc ttgattgcct tgtctgcatc gtcacaaacg
     9481 attgaggcaa taccgttttc agcattgtaa gcggcatcgg aatgcttgcc tgttacagaa
     9541 agtgaaagct gtgcgtcttt gctcatgata acgatgtctg cgcttgcggc gttaagagcg
     9601 tttgttccga ggcaagtgcc gagaacaacc gagatctgcg gtacaacacc ggaaagtgac
     9661 gcagccgcat tgagaacatc accgcaacct gcgagaagct ctgtaccctg attaagtctg
     9721 ccgccaacgc tgtcatagaa gcctacaaca ggagcgcctg tcttgagtgc aagaccatac
     9781 agctttttaa gcttggcagc ctgtgcctta ctcatggcac cgccgcaaat gtcgctgttc
     9841 tgtgcaaacg cataaacagg cataccttct actgttccaa agcctgcaac aacctcggca
     9901 aaaccctcac cggattttgc aaaggcatca atttcacaaa agctgtctgc atcaaaaaac
     9961 gccgtaattg tcttataagc ggaagttgcg gcaatttcag cctttgcctg attgatcttt
    10021 tcaatactca tcttaaaatc ctccaatacc atgtattgaa tatgcacgaa aactgagcgt
    10081 gcatactaat tttctacaca atacattata ctctataatc ttcaaaagta caagaaaaac
    10141 acgctgtact atttcaattt tgaacacatt taatagttat tccgtgaaaa cctttaattt
    10201 attgtcgaat taacaaatag tttgattgac cgtttcggaa gtatttttca aaaacggaaa
    10261 attaaagctg tttgccgttt aaaaacgggt ttgcaagcag ttttttaacc tcttgttcgg
    10321 tcaaatctct ccagtcgccc tgtttgagca tacccatttt tactccgccg atctgggtgc
    10381 gtttgagtct tgcaacctca agcccgacag cctcgcacat tcttctgatt tcacggttct
    10441 taccctcgtg aagaatcatt tcaagaacta ctctgccctg ctccttgtga atcacacgga
    10501 catatgcagg agcggttttt ctgccatcaa gctcaacgcc tgtttcaagc tttacaagct
    10561 gatcctcgtc aattgacggt cgaacggtta ctctgtaaat cttgtaaaca ttgtttttcg
    10621 ggtgcataac cttgtttgca aagtcaccgt catttgtaaa aacaagcata ccttcgctgt
    10681 ctttgtcaag tctgcctatc ggataaactc gctcgccgac attctcaaca agctgtgcaa
    10741 cacactttct gccacgctca tcattcattg tggtaatgaa tccacggggc ttgttgagca
    10801 taatatatcg gtaattaccg cccttcggca caacaatcct cttgcctctt acaaacacct
    10861 tgtctgtagg aagaacctta tcgccgagaa ttgcggtttt gccgttcacc ttgacatgac
    10921 cgccgagaat aagctcctcg gcctttctcc ttgacgcaat accgcattgc gctatgaatt
    10981 tctgaagtct tataggttca attttagcca tatgtaaatt cctttttatt aaaattttct
    11041 ttatatttaa gctgttacga aaacagattt cctattgccg aaaatattga cacgctcttt
    11101 ttatccgatt taatcttttc gcctgcaaca atgttgcatt tataaagcag ctttccgccg
    11161 agcgtgtatt caattctgcc gaccgattcg ttcttttcaa tcggagcata caaaaatctg
    11221 tctatgaaga tttttttctt gattttatcg cagtcctcac gctttaaaac gattgtgctg
    11281 ttcttctcgc ctgtaaccgt tacgctgtcc ttatcaccgc ccacgcacgg aatatcggca
    11341 caaaagtcag cgtccttgca gtcaactccc ctgtactttt caaaagcgta atcataaaga
    11401 gaaatatggt cattccagtc gttgcggtca ttcagagtga cgcacacaag cgttacaccg
    11461 tctttttttg cagaggaaac aagacaccgc cctgccaccg ttgtatagcc tgtttttccg
    11521 cctgtacagt agggataaag caacaaaagc ctgttatgat ttgcatatgc ggttttcttt
    11581 gatttcggtt caaggaattc aacggtcacg ctcttcttag ccgtaagatt tgcaaaatcg
    11641 tcattttcaa gtgcatatga cataagcaga gccatatcct ttgcacttga gtaatggttg
    11701 tcatcgtcaa gtccgctcgg cgttacaaaa ttggtattcg tcataccgat ttgctttgcc
    11761 ttttcattca ttcgttgtga aaacttttcg ggactgcccg aaatcgtata tgccgccgca
    11821 ttcgccgcat cattacccga cgccatcatc attcctgacg caaggtccga aagtcggact
    11881 ttttcaccga ctttaagata catcgaactg ccctcggcaa ccatttcctg tttgaaggtt
    11941 acttcgctgt tacaggatgc cgcctcctca agcgttatga gagatgtcat aatctttgtg
    12001 gtgctcgcag gtttcatttt ttcatctgca ttttttgaac agataaccgt gttgttgtcg
    12061 ggacaataaa gaacaaatgc ctgtgcagaa gttgtgggag gagtatcctc cgcagttttt
    12121 gcgcccataa gcacaaacgg cataacaaag cacaccgcaa gcgagattat ttttttcata
    12181 aggacacccc ctgcataaat ctatgccgag gggtgttgca atattacgaa tcagccgtca
    12241 atatcgtcct gtgtgatttc ggaaaaatcg tctgcggatt cgctcttatc ctttttgaaa
    12301 actcccttta cttttttaag aacatcggga atcatactaa cgagcttgtc ggctgtacct
    12361 tcttccctgt caacggaaac aagccttaca tcgccctgat aaacggtaag aaatgcaaca
    12421 ggctgaattg tcacacctgc accgctgccg ccgccaaagc agtctttgtt ttcctttttg
    12481 gtaggcagat ccgaaccgcc tgccgcaaag ccgtagctta cctttgaaac aggaatgatg
    12541 agtgtgccgt caggcgaagt tataggctcg ccgataatag tattgacatc aatcatttcc
    12601 ttgatttttt ccattgtggt atccattaaa ctgccgatag gatgttccat agccattctc
    12661 ctttttcaac aatatttata tcaatcattt ttaacttctg caagaagttt aatccccttg
    12721 attccgtgct taacggcaag accgataagt cggaatgcga aaatttttgc ggcaaagtca
    12781 aagttaattt ctgtttctgc tttttccgaa aaattcggat ttatgtcaac tccgtagcct
    12841 ttgcatttta caacacggac aattgtgcct actgccggat aaacaacggc acagtatttg
    12901 ccgtatttta tagccgtgtc agccgcatcg tcacctgcaa cgctgatact cagtgagaat
    12961 tttttaaccg atatgtggct gaaaaaatcc tgcaatgcag atactgcaag ctctgcaact
    13021 ttttttatca ggttcaaaag ccactcaata ccgtattttt ttataaggct cagctttttt
    13081 tctgtcgctt ttttaggttg ttcggttttc tgagtttgtt tttttgcttt tttcttcttc
    13141 ttttcctttt tgggttttgc cggcacaagc tgaagcttta caaatccgat atacacggca
    13201 caccaaaact tctctttata tgatgcacgc aaagtaatcg gaataaacat cacaagcgca
    13261 ataaacagca caattccgag taggatatat agccaaagca aagggaattc cccctaaatt
    13321 ttactgcctg tcaacaggct ggtcggcaag caaatcaatc tgctcgttgc cgttttcagt
    13381 cttttcctgt tcttcaccgt tttcttcgga ctccttg
//
