LOCUS       c00275_gnlPro..        14482 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KEDLBAPG_275.
ACCESSION   c00275_gnlPro..
VERSION     c00275_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:03:44
            Original ID  :: gnl|Prokka|KEDLBAPG_275
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14482
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14482
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2981:11363]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2982..11363
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14482
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14482
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             2..79
                     /locus_tag="ctg275_1"
                     /transl_table=11
                     /translation="DYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             150..986
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.9; E-value: 4e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg275_2"
                     /sec_met_domain="BPD_transp_1 (E-value: 9.7e-27, bitscore:
                     83.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVLVKYDFPGKRLMDGVIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSKLQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             986..1810
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60.2; E-value: 7.1e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg275_3"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.7e-19, bitscore:
                     60.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVGISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGMKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             1812..2870
                     /locus_tag="ctg275_4"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVEQVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             2982..4727
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.2; E-value: 3e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg275_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 7.2e-23, bitscore:
                     71.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.4e-08,
                     bitscore: 24.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGQKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEALERGGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEK
                     GAGER"
     CDS             4724..5038
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg275_6"
                     /sec_met_domain="Fer4_9 (E-value: 2e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.9e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.9e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             5069..6187
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg275_7"
                     /sec_met_domain="PAPS_reduct (E-value: 4.5e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             6189..7829
                     /locus_tag="ctg275_8"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYTDQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             8499..8753
                     /locus_tag="ctg275_9"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             8772..9623
                     /locus_tag="ctg275_10"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIVAVCMFSNVHGAEAAGPPAPKTLTVTP
                     TEKPKSTAKSKSASTSKSKSTPKSKSALTQKPEATPIPASTPTSEQEAETDKQNPADQG
                     TLSKPDHPDTISADKLVFIGDSRTEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQ
                     IEDNTAVIILMGVNDLYHVNDYVSYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEI
                     ESFNAAMQANLSGVTYIDVYSHLVSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQRSGI
                     WG"
     CDS             9846..11363
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg275_11"
                     /sec_met_domain="Fer4_7 (E-value: 1.3e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.6e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.4e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTVM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPNCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFRASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             11302..11427
                     /locus_tag="ctg275_12"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKVWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(11813..12913)
                     /locus_tag="ctg275_13"
                     /transl_table=11
                     /translation="MILYHISAKKLITRCTFSMLAASLILCPAVFSGCSAKTENVKNTD
                     AGSQDPISATAIKLNTAVTVTIYDSQDRELLTECMNLCDKYEKIFSRTADDSELYQLNH
                     RELTPVKGTEDTYQVSASLAELVSKGLDYSVLSEGAFDIAIEPLTSLWDFTAENPKVPK
                     DSLIQAALPKCNYHNISVDTDKNEITLKTDDTAIELGAIAKGYIADRLKDYLVSQDVKS
                     AIINLGGNVLCIGEKTDNSAFKIGIQKPFADRSETIAVMDIRDKSVVSSGIYERCFEQD
                     GTLYHHLLNPKTGYPYDNGLIAVTIISDQSVDGDALSTTCFALGLEGGMKLAESLDDVQ
                     AFFVTSDYEIHYTRDFQKKIKVTETE"
     CDS             13104..13286
                     /locus_tag="ctg275_14"
                     /transl_table=11
                     /translation="MSDAVNCEYCVNYSYDDDYECYTCEINLDEDEMVKFITGNFNQCP
                     YFKMGDEYRIVRKQM"
     CDS             13334..13963
                     /locus_tag="ctg275_15"
                     /transl_table=11
                     /translation="MENVYIMNHPLIQHKISMLRNKNTGTNEFRKLVEEIGILMGYEAL
                     RDLPVENVEVETPIETCMTPMISGKKLAVIPVLRAGLGMVNSILTLVPSAKVGHVGLYR
                     DPVTHEPHEYYCKLPEAIDERISVIVDPMLATGGSAEAAVDFVKKQGGKNIKFMCIIAA
                     PEGLKRLHEAHPDVQIYCGHLDRELNDHAYICPGLGDAGDRIFGTI"
ORIGIN
        1 tgattatggc ggatgggata aagtgcagga gaaacatttc acagatggcg gaattttcga
       61 tcagatttat gagagataaa ggaagacaag atgaagcaag agcataagca cagacagaat
      121 atatgagaca ggagaggtgg taattgatta tgaaaaaaag aaataaaccg gtgattccag
      181 ggtttgggct ctccatggga attaccattt ccatattgag tctggtagtt ctgattcccc
      241 tggcaagcct ggtggtctac acagcgaagc tgagttttaa agattttatc gaaaccatca
      301 caagggccag agtgctggca tccttttata ccagttttgt atgtgctttt gcagcagcag
      361 taataaatgg aattatggga actattcttg cgtgggtgct tgtgaaatat gattttccgg
      421 gcaagagact tatggatggg gtgatcgaac ttccctttgc tcttcccaca gcggtagcag
      481 gtattgcact gacatccctg acctcagatt cgggaattgt cggcagcttt tttgcaggat
      541 tcggtatcaa gatcgcatac acaagaatag gtattacagt ggctatgata tttgtaggaa
      601 taccgttcgt tgtgcgaagt gtacagccgg ttctggaaaa gatggataat tcttacagcg
      661 aggcagcagg agtgctggga gcaaagaaaa caactatctt ctggaaggtc atttttccgg
      721 aactgaagcc cgcgatcttt gcgggaaccg gacttgcgtt cggaagatgt ctgggtgaat
      781 atggaagtgt tgtatttatc gcaggaaata aaccctatta tacagaaatc acaccgctgg
      841 ttattatgtc aaagcttcag gaatttgatt attcaagtgc aacggcaatc gcacttgtga
      901 tgttggcagt ttcatttttt attctgttcc ttaacagtat gatacagcag agaaatgcaa
      961 gaattttaag aggaggaaat gcctgatgga caacaatgaa aagacttcgg agaaaattac
     1021 aaaatggctg cttgtcggga tcagtgttct gtttctggca gtcatgctcc ttcttcctct
     1081 gatcactgtg atcacagaag cattgcggag cggatggaag gtctatgcag ctgcagtgac
     1141 agatgagtac accatcaaag cacttcttct tacagtgaag gcaacactct ttgcagttgt
     1201 ttttaacact gtttttggtg tttttgcagc ctgggcactg acgaagtttc agttcagggg
     1261 taaaaagctt ctcactaccc tgatcgacct tccggttact atttcccctg ttattgcagg
     1321 tttgatcttt cttctgattt tcggacgaca gagtcctgtt tacttttttc tcatgaagtt
     1381 agggatgaaa gttgtattct ctgtaccggg aatcattatt gcaactgtat ttgtaacctt
     1441 tccttttatt tccagagaac tgattccggt tctggaagca gaaggaagcg atgaggagga
     1501 agcggcagcc ctgatgggag caggtggatg gaccattttc tggaagatca cattccctca
     1561 tatcaaatgg gcattactgt acggagttgt gctctgtacg gcaagagcaa tgggagagtt
     1621 tggagcggta tctgtacttt ccggacattt aagaggaaag accaatacac ttcctcttca
     1681 tgtagagatt ttgtttaatg agtttcagta tgttccggcg tttgccgtat cttcgctgct
     1741 tgtgatcatg gcagttatca ttctggtagt cagaagcctg attgaatata aaggaaagaa
     1801 ggaagcctga tatgtatgta gagttaaaaa atatcaataa gacatatggt tcttaccagg
     1861 catcaaggaa tgtgaatttc ggaattgaga aaggtaaact gattggtctg ttgggaccaa
     1921 gcggaagcgg aaaaacaact attcttcgaa tgatcgcagg tctggaaacc ccggacagcg
     1981 gagaggtcat tattgatgga aaagtggtaa atgatgttcc ggccagtcag cgtgggattg
     2041 gatttgtatt tcagaattat gcgttgtttc gctatatgac agtttatgac aacgttgcat
     2101 ttggtttgaa ggttcagaag gctgataaga agaaaattga tgccagagtc agagagttga
     2161 tcaaactggt ggggctggaa ggactggaaa aaagatatcc aagccagtta tccggcggtc
     2221 agaggcaaag ggtggcattt gccagagccc ttgctccaaa tccccaggtg ctgcttctgg
     2281 atgagccctt tgcagccatt gatgcaaaaa tccgtcagga actgcgaagc tggttaaaag
     2341 agatgatcgg gaagctggga attaccagta ttttcgttac tcatgatcag gatgaggcca
     2401 ttgaagtagc agatgagatt attatcacta atgcaggacg gatcgaacag aaaggaactc
     2461 ccataggggt ttacagaaat cctgagacag cttttacagc ttccttcttc ggacagccat
     2521 ctgtgttgaa aaatgcggat gattttcata cctttgctca ggcagaagga gcagacaaga
     2581 tcattgtccg cccggaattt gtaaaaatct ccaaactgga tgaggtggag aagttcaaaa
     2641 cttccgtatc ccggggagtg gttgaacagg tttctttcag gggagataat ctggaacttc
     2701 aggtgagagt caacaattcc gtagtaactg ccagaagaag cctggagaaa gcagatatcc
     2761 gggaaggtga gactgtgaat gtattccttt acaggatttt tgcactgaga ggtgacagtg
     2821 tacagctgat cgaaaatgag gctgtaaggg atgactttgt aattatctga cagcggtggc
     2881 tgcggcgact gacgacaaag aagaaataag aaattcagac gcaagactga tcgggaaatc
     2941 aacttgttgg cacactggta tggaggaaag ggtaagagag aatgagaaca gagagaatca
     3001 ggacagatgt gctgatcatc ggcggcggta cggcaggatg ctttgcagcc tatgtgattg
     3061 gccaaaaaag cggcagaaaa gttctgatcg cagagaaagc gaatattaag cgaagcggat
     3121 gtctggcggc gggcgtgaat gcattgaacg catatattac agaaggcaga gtgccgcagg
     3181 attatgtgga ttatgccaaa aaggatgccc atggaatcgt aagagaagac cttcttctta
     3241 ccatgtcaga gagactgaat catgtgacaa aggtgatgga agatctgggg ctggtcatcc
     3301 tgaaggacga aaacggaaaa tatgttgcca gaggaaaccg aaacatcaag atcaatggcg
     3361 aaaatatgaa gccaatcctt gcaaaggcgg cagctgaaca ggagaatgtt acggttctca
     3421 atcatgtaaa tattacagat tataaaacag aaaacaaaaa agtcacaggc gcagttggat
     3481 ttagcgttaa tgaggatatt ttctatgaca ttgatgcgaa agcagttctt tgtgccacag
     3541 gtggtgcagc gggactttac agaccgaata atccgggatt ttccagacat aagatgtggt
     3601 atcctccgtt taacacaggt gcaggatatg caatgggact tctttccggt gcagagatga
     3661 caacctttga gatgcgtttc attgcattga gatgtaagga cacgattgct cctacaggaa
     3721 ctattgctca gggtgttggg gccagacagg tcaatgcaca tggtgatatt tatgaaacaa
     3781 aatatggtct gacaacttcc cagcgagttt acggtacagt catggagaac agagaaggaa
     3841 acggtccatg ttatctcaga acggaaggta tttccaaaga acaggagcag gacctttaca
     3901 aagcttacct gaatatggca ccgtcccaga ctctgaaatg gatggaagcc ggaaaaggac
     3961 catccgaaga gaatgtagag attgagggca cagagccata tattgtaggc ggacatacag
     4021 ccagcggtta ctgggtagat aataacagag ctacaactat tgaaggttta tatgcagccg
     4081 gagacgtagc aggaggatgt ccgcagaaat atgtaaccgg cgcactggca gaaggtgaga
     4141 tcgcagcaga ggcgattttg gaatatctga atggcaaaga tgatgaccgg atcgcagcag
     4201 aaaataagga agaggcttta gagcgtggcg gagaacagga gctgtctcaa actgcaatag
     4261 ctaagaaggc agaatacgaa tcacatttga atgcttcccg ttctttgatg aatgcagagc
     4321 agcttgagga agccatgcag aagatcatgg atcagtatgc aggaggaatc ggtacagact
     4381 acagatacag cgggatgagt cttgcaaagg cagatgaaaa gattgcagca ttgttgccag
     4441 tagttgacac tctggcagca acagatactt atgaactgat gcagatttat gaacttcgcg
     4501 aacgactgat cgtgtgccag gcagtgatcg cacatctggc agccagaaag gaaaccagat
     4561 ggcatagttt cggagagaat acagactacc cgcagcagag cgaagagtgg atgaaatatg
     4621 taaactcccg tatggaaaac ggcgagatta agatcttata tcgtgacctg atcacaaagg
     4681 aaaatacagg tttgaataca gcagagaaag gagcaggtga gagatgagca ttcggattca
     4741 aaaaagtaaa tgtgcaggat gtggcagatg tatcgaagcc tgtcccggaa atctgatcaa
     4801 aaaggataaa gagaacaaag cctttatccg tcaggtaaga gactgctggg gatgtacttc
     4861 ctgtattaag gaatgcaggc atgatgccat ccgcttcttc cttggagctg atgtgggagg
     4921 cagaggtgca agtatggttg tatcagagaa accggatatt tccacatgga cagtggagaa
     4981 gccggatggc actaagatca ctattcaggt taataagaaa gacgctaata aatattaaac
     5041 ataagtatgt actctcagag tctttagagt gtgtttgaaa aatgctttac gcaagatgtg
     5101 cgtcacaatt tgtgggagat tttgttcgga tgagggcgtc gtagcgggct acgacaaccg
     5161 aattcggaca aaatataccg caaagtgggg cgtgcagatt gcgggaatga tttttcagac
     5221 acgctctagt gtatttgctc aagtacgaaa agattccgag tataaacaaa cagaggagga
     5281 taatgcaatg agtaacttat ctcatcttga tgcgcttgag gcagaggcga tttatattat
     5341 gcgagaagta gcagccgagt gtgaaaagcc ggttatgctc tattctatag gaaaggacag
     5401 ctccgttatg ctccatctgg cgatgaaggc attttacccg gagaaaccgc cattcccgtt
     5461 ccttcacatt gatactacat ggaaattcca tgagatgatt gaattccgcg acagaatcgc
     5521 aaaggaaaac ggaattgata tgctggttta caccaatgaa gagggtgtaa aggcaggaat
     5581 caatccattt gacaatggtt ctgcatatac agatatcatg aaaacacagg cgttaaaaca
     5641 ggctctgacc aaatatggat ttacagcggc atttggaggc ggccgtcgtg atgaggagaa
     5701 atccagagca aaagaaagaa tcttctcttt ccgtaattca gctcaggcat gggatccgaa
     5761 aaaccagaga ccggagatgt ggaagcttta taacactaag atccagaagg gagagagtat
     5821 gcgagtattc ccaatttcca actggacaga aaaggatatc tggcagtaca ttcagcgtga
     5881 aaatatcgaa attgtaccgt tatattttgc gaaagaaaga ccggtcatct acagagacgg
     5941 aaatatcatt atggtggatg atgacagatt aaaactccgt ccgggtgaaa agattgaaaa
     6001 caaaaaagtc agattccgta ctcttggatg ctatccgctt actggaggta ttgaatctga
     6061 agcagatact ctggatgaga ttattgatga gacgttaagt gctgtttctt ctgaacgtac
     6121 cagcagggtg atcgaccacg aggcagcagg cagcatggag agaagaaaga gagaggggta
     6181 tttctagaat gaaaggatta ttgaaattta ttacatgcgg aagtgtggat gatggaaaat
     6241 ccactctgat cggacatatt ctttatgatg caaagcttct ctatacagat caggagaaag
     6301 ctctggagct ggattccaaa gtaggaagca gaggcggtgc cattgattat tctcttcttc
     6361 tggacggtct gatggcagag cgtgaacagg gaatcaccat tgatgttgca taccgttatt
     6421 ttacaacaga taacagaagc ttcattgttg cagatacacc cggacatgaa gaatatacaa
     6481 gaaacatggc agtgggtgcg tcctttgcag atctggcagt tatcctggtg gatgcttcac
     6541 agggagtact ggtacagaca agacgtcatg caagaatctg cgcattgatg ggaatccgtt
     6601 actttgtatt tgcagtaaac aaaatggatc ttattgaata tgatgaaaaa cgtttccgcg
     6661 acattgagaa tcagatcgca gcactgatag aagaactgaa acttgccaat gtaactatta
     6721 ttccggtatc tgccacagaa ggtgacaacg ttacaaccaa atctgacaac atgccatggt
     6781 ataaaggtga ggcgcttctt tcccatctgg aaaccgtaga cattaaggaa gatacagaga
     6841 agggcttcta tatgcctgta cagagagtct gcagaccaaa ccatgagttt cgcggattcc
     6901 agggacagat tgagaatggt gccatcaggg caggcgacct tgtgactact cttcccagta
     6961 aagaagaagc tcatgtaaag agtattcttg ttggcgataa agaagttcag gaagctgtac
     7021 agggacagcc tgttaccatc cagcttgaca gagaagtaga tgtttcccgc ggatgtgtac
     7081 ttaccattga ttccggcgca gttcttacag actctgtgga agcagatatc ctctggatgg
     7141 atgacaatgc tcttacggat ggcaagaact tctttgtaaa aatcggtaca aagatgatcc
     7201 ccggcctggt tacaaagatc aattattctg tggatgttaa tacaggtgaa aagaaaagcg
     7261 cttatacctt aaagaaaaat gagattgctt cctgtactct ggaattctca gagaaaatcg
     7321 ttgtggacga atttgacagg cacagaacac tgggtgagct gatcctgata gatcgtgtca
     7381 caaatatgac ttctgcctgc ggtgttgtga gaaaaacctt tgtttctcag gatagatccc
     7441 agatcggaaa agtggacgag caggttcgtg caggactgaa aggtcagaca ccggtagtag
     7501 tggaattccc gatcggtaaa gaaggaatca ctcttgattt tgcagagcag gtagaaaagg
     7561 gactgactgt acttggaaaa catacctatc tgtatcatcc ggcagcgagt gaaaactatg
     7621 cagaaactgt ccgccatctt aaggcagcag gtctgatcgt acttcttgtt cttgatgaaa
     7681 atacagcaaa agacgagaca ttaaagactc tggatggttt ctatgcgaac tggcagattg
     7741 acggaatcac tgtgaaagat gcgattgatt tcgtgaaaaa gaaatctgca tttacagtgc
     7801 agagtgtaca tgatggaaat tatatctgat tataacaggg ctataaatcg ccgcagagac
     7861 aaagaaagtc tctgcggtat tttgttttct tgacaagtgt cgttacagcg gattatactt
     7921 attctcaaat attcagaatc cataataata cagacaggaa agataacaga aatatgcaaa
     7981 cgaacaatga aagtaaacaa aaccaaaaaa agagatgatg cttggaactt tgtttgtaat
     8041 tgctacgatc atcatcctgg cgataccaac gaagaaaaga cagaaataaa gatgagtgaa
     8101 tatcgatcag aatgtagaat gggcaattgg ttactgttca cacaccacta tcccgcgagg
     8161 tgttttggca tgaatatgcc aaaatcccga gacatacaag ccaaaattct attgccacag
     8221 gcaatctgga atgaattttg gctaagttac tatgaacgga gtgaacagta acggcaattg
     8281 tgaagtggca ttcagattac atattatgca gcagagtatg atataatcca ttttgtataa
     8341 tggcgtcagg attaagagca tatgtagagc tgtgtagcga agcggattgc gaatatctgt
     8401 ttgacttttg atgggtgtac acgaggacat ttttttacag tgaaagttat ctgtattata
     8461 ttacagaggg tactgtacag ataatcagga ggtattttat gcgtttggaa aaagtacagg
     8521 aagcgttaaa aacaaagaaa attcattatg aatatacaga ggaaaatgga tgcggaagca
     8581 tcgactttat gtttcgcggt ctgagattcc atatatggga atatgaagat cgtgtctggg
     8641 gagcggagac aaacgtgttc gaagcaggca gaagccagga tattgaagga gattacgagg
     8701 aaattatttc cggagaaatc ctctcatggc cggatatgct gcctgggatg taagtattac
     8761 tgcagaaggg aatgatattt acgaaaaaat atagaaccgg acaaattgta ttaactgcat
     8821 gtattgtagc tgtctgtatg ttttcaaatg tccatggggc agaagcggca ggtccgccgg
     8881 caccgaaaac tctgacagtt acaccgacag aaaaaccgaa atcaacagca aaatcaaagt
     8941 ctgcgtcaac atcaaagtcc aaatcaacac cgaaatctaa atcggcacta acacaaaaac
     9001 ctgaagcaac accaatacct gcatctactc caacatcaga gcaggaagct gagacagata
     9061 aacagaatcc ggcagatcag ggaactttaa gcaagccaga tcatccggat actatctccg
     9121 cagataaact ggtatttatc ggagattcca gaacagaggg attgagggat gcggtaaatg
     9181 atgacagcat ttggtcctgt ctttcttcta tgggatatga ctggatggta tctacaggag
     9241 tgcctcaggt agaagatcag attgaggaca atacagcggt tattattctg atgggtgtta
     9301 atgacctgta tcatgttaat gactacgtta gctatattaa ttccaaagct gccgaatggg
     9361 gaaacagggg agcgcagact tattttgtgt ctgtaggtcc ggtgcagaat gatccctatt
     9421 gcagtaatgc ggagattgaa agtttcaatg cggcaatgca ggcaaatctg agcggggtta
     9481 cctacataga cgtatattcc catctggtat ctgagggatt ttccaccgta gacggaaccc
     9541 actatccgga cagtgtgtct gtagatattt ataattatat tctggatcat ctggaggaac
     9601 agaggagtgg aatctgggga tgatttttta gtttatgaaa ttgtgatgct gtattgagtt
     9661 cgatggagtt tggtgatatg attgcagagg aaaaaacgaa atagagcgga aattcgtttt
     9721 tatataaaag ctgaaaacct ggtaggagga aataatgagt ggctgttttg cagcagagcc
     9781 aaaaatgtaa atgataattg cccgatgact ggacagttat caaaatccaa aatcaggagg
     9841 aaagaatgag aggactgtat tcatccaaaa cagaaatcag acacaaaatt tttacggaaa
     9901 ttgcgaggat ggcatatgaa ggccagtctc cggagatgct ggaagagctt ccctacaaga
     9961 ttgtacccgg tgaaattgcg acttatcgtg acagtatttt tctggaaaga gcggtagttg
    10021 gtgagagact tcgcgttgca atggggatgt cactgagaaa ggttacagag catgcgccaa
    10081 tctcaaaagg tgtggaagcc agcgttattg aggaaaagta ttatgaaccg ccgcttatca
    10141 atgtaatcaa gtttgcctgt aattcctgcc ctgagaaaag ggtaatgatc acagagggct
    10201 gtcagggctg tctggagcat ccctgtgtgg aggtctgtcc aaagaaagca gtacatatgg
    10261 aaggcggcag atcacatatt gatgaagatg cctgcatcaa atgcggaaag tgtctggaag
    10321 cctgtccgta taatgcaatc atcaaacagg aacgtccctg ttcaaaggcc tgcggcatga
    10381 atgccattgg ttctgacgaa tacggaagag cggagattga tcaggacaaa tgtgtatcct
    10441 gcggacagtg tctggtgagc tgtccgttca gcgctattgt agacaaagga cagattttcc
    10501 agactgttat ggcattaaaa agtgaaacac cagtgtatgc aatcgtggcg cctgccattg
    10561 caggtcagtt cccaggtatg gagaataata agatacgggg tgcatttcag gcacttggct
    10621 ttacagatgt aagagaggtt gcagtcggtg cagatttgtg cacagtggag gaggcaaagg
    10681 actttttgga ggaagttcct gagaaacttc cgtttatggc tacatcctgt tgtccgtcct
    10741 ggtctatgat ggctaagaaa ttattcccgg aacaggcgaa atgtatctcc atggcactga
    10801 cacctatggt tcttactgcc agactgatca agcagaagga accgaattgt aagatagttt
    10861 tcgtaggtcc ctgtgcagcc aagaagctgg aagccagccg taagagtatc cgcagctatg
    10921 tggattttgt gctgaccttc gaggaagtag caggaatgtt tgatgccaaa ggcgtggact
    10981 ggaaagatat tccggaagga gaaccactgt ttcgtgccag tgctgacgga agaggtttcg
    11041 cagtcagcgg tggtgtggca gaagcggttg tccatgcggt gaagcgtatt gatcctgatc
    11101 gggaagtaaa ggtaatgaat gcagaaggtc tgcagaactg taagaagatg ctccagatgg
    11161 ccaagattgg taaatataat ggatatctgc tggaaggaat ggcatgtccg ggcggctgtg
    11221 tagcaggtgc cggtactatc cagacagtta aaaaagcagc agcggctctc gaaaaaatga
    11281 agaaagaggc ttcgtttaca gatgcctatg actccaaata cagagcaaga ctggaaagtc
    11341 tggagaaatt tgatgtggag tgagattctg actgaatcag tgaaatctta tatggattgc
    11401 aagtgtttga atgcaatcag tatatagcag actaaaaatg aataatcgtc agaagaactg
    11461 tcaggctgag tgataagttt aactgaatcg gataagtccc ctgcggaggt tgcgaaaagc
    11521 aataagcagg ggatttttgt catctgtgca atactgactt aaatcaaaaa aagtttcata
    11581 caagtcatga aataattagc agtatgttga ctgagatttt atagaataac aaattaagtc
    11641 aagcgaacaa gcaaaaatat ttgactggaa atttacaaat tgcaaattag gtcaagaaat
    11701 tagtgtggat tgtatgactt gaaaatcaaa atctattgat taagtcaaaa cgccagttaa
    11761 taattgttga tttatatttc tgttttttca atttaagtca tcagagacag atttattctg
    11821 tttccgtaac tttgattttt ttctggaaat ctctggtata gtgaatctca taatcagaag
    11881 ttacgaaaaa tgcctgtaca tcgtccagag actcggccag tttcatgcca ccctccagac
    11941 caagagcaaa gcaggtcgtg ctcagcgcat ccccatccac agactgatcg gaaataatgg
    12001 taactgcaat cagcccgtta tcataaggat agccggtttt aggattgagc aggtgatgat
    12061 acaaagtgcc atcctgttca aagcatctct cataaattcc tgaggaaacc actgacttat
    12121 ccctgatgtc cataacagca atagtttcgc ttcggtctgc aaatggtttc tggatcccga
    12181 tcttaaaagc agaattgtct gttttttcgc caatacagag aacatttccg ccaagattga
    12241 tgatcgcact ttttacatcc tgagaaacca gataatcctt caggcggtct gcgatataac
    12301 ccttggcaat ggcaccgagt tcgattgcag tatcgtctgt ctttaatgta atctcatttt
    12361 tatctgtatc aacagagata ttgtgataat tacatttggg cagtgctgcc tggatcagac
    12421 tgtccttggg cacttttgga ttttcagcag taaaatccca cagagaagtc agcggttcaa
    12481 tagcaatatc aaatgcaccc tcagataata cagaataatc aagtccctta gaaaccagct
    12541 ccgccagaga agccgacacc tgataagtat cctctgttcc cttcacaggt gtaagttccc
    12601 gatggtttaa ctgatataat tcactgtcat ctgcggtgcg gctgaatatt ttctcatact
    12661 tgtcacaaag attcatgcat tctgtaagca gctctctgtc ctgagaatca tagatagtga
    12721 ccgtaactgc agtattcagt ttgatcgcag tggcagagat gggatcctgg gaaccggcat
    12781 ccgtattttt gacattttcc gtttttgccg aacatccgga aaaaacagcc ggacataata
    12841 taagagatgc tgcgagcatt gaaaaagtac agcgtgttat taattttttt gcagatatat
    12901 gatataatat cataaatgta acctcatagt tattttatgg aattgctata agcaatagtt
    12961 cagggaagaa atatcttttg atcccaacac catagtatat cagaaacagc aaactttgca
    13021 caggtacaaa ggcaacagaa aaaatccaaa aggagatacc ggatagaaat gaaatatgcc
    13081 ggaaacaaag agaggagtaa ataatgtccg atgcagtaaa ctgcgaatat tgtgtaaact
    13141 acagttatga tgacgactat gaatgctaca cctgtgaaat aaatcttgac gaagatgaaa
    13201 tggtgaagtt cattaccgga aacttcaatc agtgtccata cttcaagatg ggtgacgaat
    13261 accgcattgt acgtaagcag atgtagaatt tataaaaagt aacaaatatt caactaagcg
    13321 aggaattaag ataatggaaa acgtttatat tatgaatcat ccgctgatcc agcataaaat
    13381 atccatgctg agaaacaaaa acacaggaac aaatgaattt cgtaaattag tagaagagat
    13441 tggaatcctc atgggatacg aagctctccg ggatcttcct gtagaaaatg tagaagtaga
    13501 aacccctatt gaaacctgca tgacaccaat gatctcagga aagaagctgg cggttatccc
    13561 tgtgctccgc gcaggccttg gaatggtaaa cagtattctc acacttgtgc catctgcaaa
    13621 agtaggccat gtaggactct atcgtgatcc tgtaacccat gaaccacacg aatactactg
    13681 caaactcccg gaagcaattg atgaacgaat ttcagtgatc gtagatccaa tgctcgcaac
    13741 cggtggctcc gcagaagcag ccgttgactt tgtcaaaaaa cagggcggaa aaaacattaa
    13801 attcatgtgc atcatcgcag cccctgaagg gctcaaacgt ctccacgaag cacatccgga
    13861 tgttcagatt tactgtggac accttgatcg tgagttaaat gaccacgcct acatctgccc
    13921 aggccttgga gatgccggag accgtatctt tggcacaata taagaataac gtgattcgtt
    13981 acatcttata cctatactgt actatactat actgcgcata tgaagaactc accctgcatc
    14041 aatatagcag aaatttgttt tatgatatac tgacaatttg ttactgttca ctccgttcac
    14101 agtaacgtag cccaaatcca ttccagattg cctgcggcaa tggaattttg gcttgtatgt
    14161 ctcgggattt tggcatattc atgccaaaac acctcgcagg acagtggtgt gtgaacagta
    14221 acgacaattt tccaactacc agcgtaagca ggattctctt ttggggtgaa tcttgtaggg
    14281 agtgtagcaa ctcttaggcc tgcggaatct gcgttatgaa aaaagaaggc aactgtctga
    14341 tccgcaggcg agttttgcct tcttttttca tgcacttagc agattttgca ggccttagag
    14401 ttcctgctcc cgaaactgaa ccccaaaaga gaatcctgct tacgcgtccc ttaatgaaaa
    14461 aatcaacaaa aaaccgaaaa aa
//
