LOCUS       c00099_gnlPro..        13872 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OKBNLKHF_99.
ACCESSION   c00099_gnlPro..
VERSION     c00099_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:15:10
            Original ID  :: gnl|Prokka|OKBNLKHF_99
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13872
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13872
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[311:3872](-)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(312..3872)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..13872
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13872
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             193..351
                     /locus_tag="ctg99_1"
                     /transl_table=11
                     /translation="MNAPTDKLSSKQNLPNTANAIFGRIFYLFTYSLCTSFRQNYSASG
                     RLASFSR"
     CDS             complement(312..3872)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_2"
                     /sec_met_domain="PFOR_II (E-value: 4.5e-19, bitscore: 59.5,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.3e-82, bitscore: 265.2,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.9e-33, bitscore: 104.7,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.3e-14, bitscore:
                     43.0, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 3.5e-11, bitscore: 34.7,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 2.2e-07, bitscore: 21.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 1.9e-09, bitscore: 28.2,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.0001, bitscore: 13.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 6.2e-21, bitscore: 64.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LARKMKTMDGNSAVAHVSYAFTDVAAIYPITPSSVMADLTDKFSA
                     QGAKNLFGRQVQVTEMQSEGGASGAVHGSLAAGALTTTYTASQGLLLMIPNMYKMAGEL
                     LPGVIHVSARALTSHALSIFGDHSDIYACRQTGYAMLCSNNPQECMDLAAVAHLAAIEG
                     RVPFLHFFDGFRTSHEIQKIEEWDYADLADMLNWDAVEAFRRRALNPEHPVTRGTAQND
                     DIFFQAREACNKYYDAVPEVVVKYMDKVNAKIGTDYKPFNYYGAEDAEHVIVAMGSVCD
                     CTEEVVDYLNAAGEKVGLLKVHLYRPFVADYMLRELPKTVKTISVLDRTKEPGSIGEPL
                     YLDVLAAINGSDFAGVKVYTGRYGLGSKDTTPGDIIAVYRNAESETPKRRFTIGIVDDV
                     TNLSLPIVENPDTTPKGTHSCKFWGLGADGTVGANKNSIKIIGDNTDMYAQGYFAYDSK
                     KSGGLTVSHLRFGKTPIKSTYYISKADFVACHNPSYVDKYDIVDDLKEGGSFLLNCPWD
                     TEELSERLPGKMKKILAERHINFYTIDGIKIGKEIGLGGRINTVLQSAFFKIADIIPAD
                     KAKELMKAAAKKSYMKKGQAIVDMNYAAIDRGMEDLKKVEIPADWANAVDNSVADKAEG
                     NGALVEYVNEILKPVNAYKGNKLPVSTFMDHVDGTAPNGSAAYEKRGIAVDVPEWNPEN
                     CIQCNRCAIVCPHAVIRPVAMTADELAKAPEGTKSLPMMGLKDLNFVMTVSTLDCTGCG
                     ACAQVCPGKKGAKALTMQPIDSQRPKQAVFDYALTLEDKPEVHEKFKFTTVKGSQFKQP
                     LLEFSGACAGCGETPYAKLVTQLFGDRMFIANATGCSSIWGASAPATPYTKNKKGYGPA
                     WQNSLFEDNAEFGLGMALGQKAIRNRLIEYVEGIQKDTDSADLKTACQNYLDTVTDSTS
                     SRPATDALIAELEKNTEDAKVGELVKKTLVDKDELAKKSMWIFGGDGWAYDIGFGGLDH
                     VIASGENVNILVFDTEVYSNTGGQASKATPVGSVAQFAAAGKAVKKKDLAAIAMSYGYV
                     YVAQCAMGADNNQVLKAMVEAESYNGPSLVICYAPCINHGIKGGMGIAQLEEKKAVEAG
                     YWNIFRYDPRLADEGKNPFMLDGKAPSASYRDFIMGEVRYNSLTRSFPERAEKLFEKAE
                     KVAADKYAHLEKLASLPDAE"
     CDS             complement(4522..4938)
                     /locus_tag="ctg99_3"
                     /transl_table=11
                     /translation="MRGLFNRFANFMQGRYGTDKFNNALWVLLLILWFVNIFVWNRVAR
                     YIIDGIMLLIIVLICFRMFSRNIVARSAENRKFLPIYNAVTGWFKLTFKKIRDRKDYRY
                     IKCPVCKAQLRVRNKKGNHTVRCPKCGSEFNKKI"
     CDS             complement(5048..7447)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) B12-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pterin_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_4"
                     /sec_met_domain="B12-binding (E-value: 1.2e-21, bitscore:
                     67.8, seeds: 91, tool: rule-based-clusters)"
                     /sec_met_domain="Pterin_bind (E-value: 5.3e-42, bitscore:
                     134.8, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VFKNFSNFSEYLNQKNFILLDGATGTLIQKSGVKYDHVPEVLNIT
                     HPELIESFHRRYIDAGSDIVYANTFGANAYKLQDSGYSVEEIIGAGVKIARKAVEGTDA
                     LVALDIGPIGQLLEPAGSMKFDEAYEYYKQQILAGKDADVIVFETMTDLYELKAAVLAA
                     KENCDKPILTTMTFERNGRTFTGVSPACAAVTLTGLGVDALGVNCSLGPDELEPVVSEM
                     SKYTNLPLVIKANAGLPDPNSNEYNIMPDKFAECVCSLLKYGVKVIGGCCGTNPDYIAK
                     IKSEVADREYQPQTKSVDTTVCSSTTVVEINGPRIIGERINPTGKKLFKQALVENNIDY
                     ILTQALSQVQGGAEILDVNVGHPEIDEKKMMVRVLKAIQSVCDVPLQIDSTKPEVIEAG
                     LRYYNGKPILNSVNGEEQSLATVLPLVKKYGASVVGLALDENGIPKTAEGRFEIAKRIV
                     ERAEAVGIDRKDVYIDCLTLTVSAEQAACRQTLEALHRVKTELGCKTCLGVSNISFGLP
                     NRELVNRTFLTMAMEQGLDLPIINPNVESMTGAVRAFRVLNGIDKNSLEFINAYNDAVP
                     AAPVKKADSNVDIFAAVYNGLKNEGAAATAKLLETTDAMQVVNEMLIPALDRVGEDFEK
                     NKIFLPQLIQSANTAQECFDVIKKHLTKTSGTPVSKGKIIVATVKGDIHDIGKNIVKVL
                     LDNYGYTVVDLGRDVDPQLIVDTAVEQNITMIGLSALMTTTLKSMEDTIRLVRECKELK
                     NPDGSSKCTIFVGGAVLTKDYAMKIGADYYCRDAKESVDTAKLVLG"
     CDS             complement(7440..8084)
                     /locus_tag="ctg99_5"
                     /transl_table=11
                     /translation="MITLDRLNRKEAIRYLGGAGISLNYRMDVLMDECEKEILKTAEPR
                     FLYVERKAPFDDILLGNDIKKHLEGCHTAVMMCATIGSEIDKLIRISQISDMARAVVLD
                     SFASVAVEQVCQKVDEILAEKYSGKYMTFRFSPGYGDYPIEMQKEYLRILDAPRKIGLT
                     TGDSCLLVPSKSVTAVLGISDNPIERRKRGCAICSMKGKCRFRRNGEHCGV"
     CDS             complement(8081..8941)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MTHFR"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_6"
                     /sec_met_domain="MTHFR (E-value: 1.1e-85, bitscore: 278.1,
                     seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISNLFNSGKTVFSFEVFPPKKTSPIESVYGKLEEISALKPDFI
                     SVTYSAGGSGSKSRTCEIATKIKRDFGVESVAHLTCINSTKADIDRNLALFKENGIENI
                     LALRGDRVEGVEPQKDFAYASDLCRYIASQGDFDIAGACYPEVHSEATDEVEDIHNLRK
                     KVESGASHLISQLFFDNSVYYRFLERAKIAGVNVPIEAGIMPVTSKSQIERMVSMCGAS
                     LPAKFAKIMQKYDTRPEALRDAGIAYAVDQIVDLIAHGVDGIHLYTMNNPYVARKITEA
                     VSSLL"
     CDS             complement(9298..10668)
                     /locus_tag="ctg99_7"
                     /transl_table=11
                     /translation="MMEQVNVTLTETIKVLLDDKKFSTLRDILITMKPFDIAAVFENLQ
                     DEKMPILFRILPKELAAETFVEMDDETQEFLIHGFSDSELKEVVDELFVDDAVDLIEEM
                     PANVVKRILRQADKDMRKQINELLKYPEDSAGSIMTTEFIVLRPDMTAEMAIKRIRRTG
                     VDKETIYTCYVTDANNKLIGITTVKDLLLAEDDELVRSIMEENVISVTTLADQEQVAQM
                     FSNYNFLALPVVDNENRLVGIVTIDDAIDVIQEEATEDIEKMAAVLPSDKPYMKTSVFG
                     LYKKRAPWLLILMLSATFTSAIISSFEAVLANVLILSSFIPMITGSGGNAGSQASVSVI
                     RALSLGEIHFRSIFLVLWKEFRVSILCGITLAAANFIKLLLFDLNGQENAFMIALVISL
                     TLVGTIIMAKLVGSSLPLLASKVGFDPAVMANPLISTVCDSLSLLIYFGVAKLILHL"
     CDS             11089..11730
                     /locus_tag="ctg99_8"
                     /transl_table=11
                     /translation="MTDMVKKYVPYAVIILLVYMLLPLVFIPGAMQKFSPVAYDCVFPI
                     TAIGCSAHYCSKHGLDFLFALIAPIIYLPSMLIYNGGFSSSTLSTNLILLVVYLVAGIF
                     GLFLGDLAFGDKRRQKEKAEQEEAEEMLLEAKRREKEELENMTSSSKKSERKAPYRQER
                     KPARKPSPAPQKTETADDDDFDYDKYLSGIDRKQDPNESEIDDILNEYRH"
     CDS             complement(12237..13145)
                     /locus_tag="ctg99_9"
                     /transl_table=11
                     /translation="MKSIIKKLTAIAMCGVLTVGSVLMTGAVSEYEDRKDFEVTGTTQK
                     ISNNQLFVTTTGYTENTAKNFGAMFISTDYQKYSVMFKDCIDAPKFVNLPKNQEFTRHM
                     ITADNRYFGDTGMKFNYDSTGGEYVKIRIKLSDYFPDGFNDDGTMTGKLSDGTYKNFDF
                     TYEDFGTDSSGKPCYATSGAYFVSGGAVTSFVPDKNGYAEFYISRQLGEDTGLMAYKYC
                     RLKNGAECKTTIGGKLNCLTCGDAYPDGNITVVDATSVQKYVVGIVKFGKTQLFNSDVN
                     HDGEISVVDATLIQKYIVGLI"
ORIGIN
        1 attttataat cgttgcgatt ggcgaacccg gttcgccgct actgaattgt aatatttata
       61 aaaagtgtat ataacaaaac tgtgctgcca ttacttactg gcggataata tccgccccta
      121 cagacgatac atagctttca ttacatcaaa aaatatttgt taaacataaa atttcatcaa
      181 ggcgggcgtc caatgaacgc ccctactgat aaactttcat ctaaacaaaa tctcccgaac
      241 acggcaaatg ccatattcgg gagaattttt tatttattca catattcact ttgtacaagc
      301 tttaggcaaa attattcggc atcgggaagg cttgcaagct tttcaaggtg agcatactta
      361 tcagcagcaa ccttttcagc cttttcaaag agtttttctg ctctttcggg gaatgaacga
      421 gtgagtgagt tataacgaac ttcgcccatg atgaagtcac gatatgatgc agaaggagcc
      481 ttgccgtcaa gcatgaacgg attctttcct tcgtctgcaa gacgaggatc gtaacggaag
      541 atgttccagt aaccagcctc aacagccttt ttctcttcaa gctgagcaat acccatgcca
      601 cccttgatac cgtggttgat acacggagcg tagcagatta cgagtgacgg accgttgtag
      661 ctttcagcct caaccatagc cttgagaacc tgattgttgt cagcacccat agcgcactgt
      721 gcaacataaa catagccgta gctcattgca atagcggcga ggtctttctt cttaacagcc
      781 ttacctgcgg cggcaaactg tgcaaccgaa cctacaggag tagcctttga agcctgaccg
      841 cctgtgttag aataaacctc agtatcgaat acgaggatat taacattttc gcctgatgcg
      901 attacatggt caagaccgcc gaaaccgata tcgtaagccc aaccgtcacc gccgaagatc
      961 cacattgact tcttagcaag ttcgtccttg tcaacgagtg ttttcttaac aagttcgcca
     1021 acctttgcat cctctgtgtt cttttcgagt tcagcgataa gagcgtctgt tgcaggacgg
     1081 cttgaagttg aatctgttac agtgtcaaga tagttttggc aagctgtctt gaggtcagcg
     1141 ctgtctgtat ctttctgaat accctcaaca tactcaataa gtctgttgcg gatagccttc
     1201 tgaccgagag ccataccaag accgaactct gcgttatctt caaagagtga gttctgccaa
     1261 gcaggaccat aacccttctt attctttgta taaggtgttg caggagcaga cgcaccccaa
     1321 attgatgaac agcctgttgc gttagcaatg aacattctgt caccgaaaag ctgtgtaaca
     1381 agctttgcat acggtgtttc accgcagcct gcgcaagcgc ctgagaattc aagcaacggc
     1441 tgtttgaact gactgccctt aactgtagtg aacttgaact tctcgtgaac ttcaggctta
     1501 tcttcaagtg tgagagcgta gtcaaatact gcctgcttag gacgctgtga gtcgattggc
     1561 tgcattgtga gagccttagc gcccttctta cccggacaaa cctgagcaca agcgccgcaa
     1621 ccagtacagt cgagtgttga aactgtcatt acaaagttga ggtccttaag tcccatcatc
     1681 gggaggctct ttgtaccctc gggagctttt gcaagctcat cggctgtcat ggcaacagga
     1741 cggattacag cgtgaggaca tacgattgca catctgttac actgaataca gttttcagga
     1801 ttccattcgg gaacatcaac tgcgatacct ctcttttcat aagcggcaga accgttagga
     1861 gcagtaccgt caacatgatc cataaatgtt gaaacaggga gcttgttacc cttatacgca
     1921 tttacaggct tgaggatttc gtttacatac tcaacgagag caccgttacc ctctgccttg
     1981 tcggcaactg aattatcaac agcgttagcc caatcagcag gaatttcaac cttcttgagg
     2041 tcttccatac cacggtcgat agcggcgtag ttcatatcta cgatagcctg acctttcttc
     2101 atgtatgact tcttagcggc agccttcata agctccttag ccttgtcggc aggaatgata
     2161 tctgcaatct tgaagaatgc tgactgaaga actgtgttga tacgaccgcc aagaccgatt
     2221 tccttaccga tcttgatacc gtcaattgtg tagaagttga tgtgtctttc agcgagaatc
     2281 ttcttcatct tacccgggag acgctcggaa agctcttctg tatcccatgg gcagttaaga
     2341 aggaatgaac cgccttcttt aaggtcatca acaatatcgt acttgtcaac ataagacgga
     2401 ttgtgacagg caacaaagtc tgcctttgaa atgtagtatg ttgacttaat gggagtttta
     2461 ccgaaacgaa ggtgagaaac tgtaagaccg cccgacttct ttgagtcata tgcaaagtag
     2521 ccctgagcgt acatatcggt gttatcgccg ataatcttga ttgagttctt gttagcaccg
     2581 acagtaccgt cagcaccaag accccagaac ttacagctgt gtgtaccctt cggagttgta
     2641 tcgggatttt caacaatcgg aagtgagagg tttgtaacat catcaacgat gccgattgta
     2701 aatcttctct taggtgtttc gctttcagcg tttctgtaaa cagcgatgat gtcgcccggt
     2761 gttgtatcct ttgagccaag accgtatctg cctgtgtaaa cctttacacc tgcaaagtcc
     2821 gaaccgttga tagcggcgag aacatcaaga taaagaggtt cgccgattga acccggttcc
     2881 tttgttctgt caagaacaga gattgtctta acagtcttag gaagctctct gagcatatag
     2941 tcggcaacga aaggtctgta aaggtgaact ttaagaagac cgaccttttc gcctgcggca
     3001 ttgaggtaat caacaacttc ttccgtacag tcgcagacag aacccatagc aacgataaca
     3061 tgctctgcat cctctgcacc gtagtagttg aacggcttgt agtcggtgcc gattttagca
     3121 ttaaccttgt ccatgtactt aacaacaact tcgggaactg cgtcataata cttgttacaa
     3181 gcttctcttg cctggaagaa gatatcgtcg ttctgagcag tacctcttgt tacaggatgc
     3241 tcagggttaa gagcacgacg acggaaagcc tcaactgcat cccagttaag catatcggcg
     3301 aggtctgcgt aatcccactc ctcaatcttc tgaatttcgt gagaagttct gaaaccgtca
     3361 aagaaatgaa ggaaaggaac tctgccctca atagctgcaa ggtgagcaac agcagcaagg
     3421 tccatacatt cctgaggatt gtttgaacaa agcattgcat aacctgtctg acggcaagcg
     3481 tagatatctg agtggtcacc aaaaatagaa agtgcgtggc ttgtgagcgc acgagctgat
     3541 acatgaataa cgcccggaag gagctcgcct gccatcttgt acatattcgg aatcataagg
     3601 agcaggccct gtgatgctgt gtaagttgtt gtcaaagcac ctgctgcgag tgagccgtga
     3661 acagcacctg atgcgccgcc ctccgactgc atttccgtta cctgaacctg tctgccgaaa
     3721 aggttctttg caccctgtgc cgagaacttg tcggtaaggt cagccattac ggaagaaggt
     3781 gtaataggat agatagccgc aacatcggta aacgcataag aaacatgagc tactgcgctg
     3841 ttaccatcca tagttttcat ttttcttgcc aatggaatcg tcctcctttt taatcaaagc
     3901 ggcaaaggaa atgatgccgc ataaattttc gatacccgtt aattacgcac cgtaaatcaa
     3961 caagcggtac ggatactttg tatcatctta aattttatca cttaaacacc gatttgtaaa
     4021 gtgttttaca caagaaattc aaagcaggat atatattttt gtttcgtttt ttacaaaaaa
     4081 gttttttata tttacttgtt cctgtcaaaa tactttgttg ttgatttttt aaaaatcaac
     4141 aacaaagctt ttggttattt gtacaaacgg ttgcaatact acgctcgggc ataatttgtt
     4201 ttttgacatt gcaatctatc tacacgaatt gggaacggcg gctcgccgta attttcaatt
     4261 tataaatgct ttatcgcttc gcttaaatcc gtacacaaaa aatctatcat atgacgagcc
     4321 gactgccgca agggcattgt cgcccacata ttttccgacc atccatgtat cggcaaggtt
     4381 gtaaaactgc tgaaacacat tgccgagcat aagcggtact gcaaaagacc acaggccgcc
     4441 tgttatactg cctgtggtca aatctctgct tttatttagt tttatcacaa aatcatttcg
     4501 ttacaaccgc agattctgcg gtcatatttt tttgttaaat tcacttccgc atttcggaca
     4561 gcgaacagta tgattgcctt ttttgttgcg aacacggagc tgcgccttgc acacgggaca
     4621 cttgatataa cggtagtcct tgcggtcacg aattttcttg aaggtcagct tgaaccaacc
     4681 tgttaccgca ttgtaaatcg gaagaaattt tctgttttcg gcacttcttg caacaatgtt
     4741 gcgtgagaac atacgaaaac agataagcac gataatcaag agcattattc cgtcaatgat
     4801 gtatcttgca acacggttcc acacaaaaat attcacgaac cacagtataa gcaacagcac
     4861 ccagagtgca ttgttgaact tatccgtgcc gtatctgccc tgcataaaat tggcgaatct
     4921 gttaaataat cctcgcataa agttcatcct ttccgcaaaa agcggtaatt acaaaaatca
     4981 tccttccacc attttatcac aggcagggca tacattcaat aaacatttga cgatatatgt
     5041 cactaaatca gccgagaacg agctttgccg tgtcaacgct ttcttttgcg tcacggcagt
     5101 agtagtcagc gccgattttc atagcatagt cctttgtaag aaccgcaccg ccgacaaata
     5161 ttgtacattt gcttgagcca tcgggattct taagttcctt acattctctt acaagcctta
     5221 ttgtgtcttc catactcttg agggttgttg tcataagagc cgaaagtcct atcattgtaa
     5281 tattctgttc aacggcagta tcaacaataa gctggggatc aacatctcga ccgaggtcaa
     5341 cgactgtgta gccgtagtta tcaagaagaa cctttacaat gttcttgccg atatcgtgaa
     5401 tgtcaccctt tacggttgcc acaataattt tgcccttgct tacgggagtt ccgcttgtct
     5461 ttgtaaggtg ctttttaatt acatcaaagc actcctgagc tgtgtttgcg ctttggataa
     5521 gctgtggaag gaagatttta ttcttttcaa aatcttcacc cactctgtca agtgcaggga
     5581 taagcatttc gtttacaacc tgcattgcat cagttgtttc aagaagcttt gcggttgcgg
     5641 ctgcaccttc gtttttaagt ccgttataaa cagccgcaaa aatatcaaca ttgctatctg
     5701 cctttttaac gggagcggca ggaacagcat cgttatatgc gttgataaat tcaagcgagt
     5761 tcttgtcaat gccgttaagc acacggaatg ctcttacagc gcctgtcatc gactcaacat
     5821 ttgggttgat aatcggcaaa tcaagtccct gttccatagc cattgtaagg aaagttctgt
     5881 tgacaagctc acggttcgga agtccgaacg aaatgtttga tacaccgaga caggttttac
     5941 agccaagttc cgtttttact ctgtgcaagg cctcaagagt ctgacggcaa gccgcctgtt
     6001 ctgcggaaac cgtaagagta agacagtcga tatatacatc ttttctgtca atgccgacag
     6061 cctcggctct ttcaacaatt cgttttgcaa tctcaaatct gccctcggcg gttttcggga
     6121 taccgttttc gtcaagtgca agtccgacaa cagacgcacc gtactttttg acaagaggaa
     6181 gaaccgttgc aaggctctgt tcctcaccgt ttacggagtt cagaatcggt ttgccgttgt
     6241 aatagcggag tcctgcctca ataacctcgg gctttgtgga gtcaatctgg agcggaacat
     6301 cacacacact ctgaatagcc ttgagaacac gcaccatcat ctttttttcg tcaatttcgg
     6361 gatgacctac attgacatca agaatttccg caccgccttg aacctgactg agagcctgag
     6421 tgaggatata gtcaatatta ttttcaacaa gcgcctgctt aaacagcttt ttgcctgtgg
     6481 ggttaattct ttcgccgata attctcggac cgttgatttc gacaaccgtc gttgaactgc
     6541 aaacggttgt gtcaacgctc tttgtctgag gctgatattc tctgtcggca acctccgact
     6601 taatttttgc aatataatcg ggattcgttc cgcagcatcc gccgataacc ttaacaccgt
     6661 atttgaggag tgaacaaacg cactcggcaa atttatcggg cataatgttg tactcgttgc
     6721 tgttaggatc gggcaaacct gcgttagcct tgattacaag gggaagattt gtgtatttcg
     6781 acatctcgga aacaacaggt tcaagctcgt ccggaccgag tgaacagttt acgccgagag
     6841 cgtcaacacc gagtcccgta agagtgacag ccgcacaggc aggcgataca cccgtaaatg
     6901 ttcgtccgtt tctctcaaag gtcattgttg tgaggatagg cttgtcacag ttttcttttg
     6961 cggcaaggac tgcggcttta agctcgtaga ggtcggtcat tgtttcaaaa actatgacat
     7021 cggcatcttt accggcaaga atctgctgtt tgtaatactc gtaagcctcg tcaaatttca
     7081 ttgaaccggc aggttcaagc agctgaccta tcggaccgat atcaagggca acgagggcgt
     7141 ctgtaccctc aacggctttt cttgcaatct taacaccggc gccgatgatt tcttcaacgc
     7201 tgtaaccgct gtcttgaagc ttgtaggcat ttgcaccgaa ggtgtttgcg tacacaatgt
     7261 cagaaccggc atcaatatac ctcctgtgaa agctctcgat aagctcgggg tgagtaatgt
     7321 tcagcacctc aggcacatgg tcgtacttta caccgctttt ctgaattaga gttcctgttg
     7381 caccgtcaag cagaataaaa ttcttttggt tgagatattc actaaagttt gaaaaattct
     7441 taaacaccac aatgttcccc atttcttctg aagcgacatt tgcctttcat actgcaaatt
     7501 gcacaccctc gttttcttcg ttcaatcgga ttgtctgaaa ttccgagaac cgccgtaacc
     7561 gactttgacg gcacaagcaa acagctgtcg cctgttgtaa gacctatttt tctcggagcg
     7621 tcaagtattc tcagatactc cttctgcatc tcaataggat agtccccata gccggggctg
     7681 aaacggaagg tcatatactt tccgctgtat ttttcagcaa ggatttcgtc aaccttttga
     7741 cacacctgtt caacggcaac gcttgcaaag ctgtcaagca caaccgccct tgccatatcg
     7801 gaaatctgac ttatacggat aagcttgtca atttccgaac cgattgtagc acacatcata
     7861 acggctgtgt ggcaaccctc aaggtgcttt tttatatcat tgccgagtaa aatatcgtca
     7921 aacggagctt tgcgttcaac atagagaaat ctcggctctg ctgttttcag tatttctttt
     7981 tcgcattcat ccatcagcac atccatgcgg taattaaggc tgattcctgc accgccgagg
     8041 tagcgtatag cctcttttcg gtttaatctg tcaagtgtta tcataaaaga cttgacaccg
     8101 cctccgtaat ttttcttgca acatacgggt tgttcattgt gtagaggtgg atgccgtcaa
     8161 caccgtgtgc gataaggtca acaatctggt caaccgcata tgcaatgcct gcgtcacgca
     8221 aagcctcggg tcttgtatca tacttctgca taatctttgc aaattttgca ggaaggcttg
     8281 caccgcacat tgaaaccatt ctttcaatct gacttttgct tgttacaggc ataatacctg
     8341 cctcaatcgg aacatttacg cctgcaatct tcgctctttc aagaaagcga tagtaaacgg
     8401 agttgtcaaa gaaaagctgt gaaataaggt ggcttgcacc cgactcaacc tttttgcgaa
     8461 ggttgtgaat gtcctcaacc tcatcggttg cctcgctgtg aacctcggga taacaagcgc
     8521 cggcaatgtc aaaatcaccc tgtgacgcaa tgtatctgca caaatcgctt gcataagcga
     8581 aatccttctg cggttcaaca ccttcaaccc tgtcaccacg gagtgcaaga atattctcaa
     8641 tgccgttctc cttaaagagt gcaagattgc ggtcaatatc agcctttgtg ctgttaatgc
     8701 aggtgaggtg tgccacggat tcaactccga aatctctctt gatttttgtt gcgatttcgc
     8761 aggtacggct ctttgaaccg ctgccgcctg cactgtatgt tacgctgata aagtcaggct
     8821 ttaaagccga aatttcttca agcttgccgt aaaccgattc aatcggagag gtctttttag
     8881 gcggaaatac ttcaaaagaa aaaactgttt ttccgctgtt aaataaattg cttattttca
     8941 tatataaaca cctcggtaat ggttttgtta aacttgatta attatagcat aaataatttt
     9001 tgcatacaat actgttttgg tgggttttgt cgtttaagac tatcattttt ttggaggtct
     9061 gggtataaac aaaaattata tccaagagtt ttataataat tataatttcg ttaacaaacc
     9121 aaattctcca ctacagagta tacatttact ttcataataa agcaaaaatt gcatcaatgc
     9181 cgtattcggg catctgatgc aattcctata tccgagtatt ttctcgaata gattgcggtg
     9241 gcacaccgcc gagcgcaatt ttcaattttc aattttcaac tttcaatttt aaaaaaatca
     9301 cagatgcaaa atcaactttg caacgccgaa atagataagc aatgaaagcg agtcgcagac
     9361 tgttgaaatg agcggattcg ccataacggc agggtcaaag ccgaccttgc ttgccaaaag
     9421 aggcagactg ctgccgacaa gctttgccat aataattgtg ccgacaagcg taagcgaaat
     9481 tacaagggca atcataaatg cgttttcctg accgttgaga tcaaacaaaa gcagttttat
     9541 aaagtttgcc gccgcaaggg taataccgca aagaattgac accctgaatt ctttccacag
     9601 cacaaggaaa atgctcctga aatgaatttc accgagcgac aacgcacgga ttacggaaac
     9661 cgacgcctga gaacctgcgt taccgcccga acccgtaatc atcgggataa acgatgagag
     9721 aatcaaaaca tttgcaagca cagcctcaaa tgatgagata atcgcacttg taaaggttgc
     9781 cgaaagcatg agtataagca gccacggcgc tctctttttg tacagaccga aaacgcttgt
     9841 tttcatatac ggtttgtcag acggcaatac ggcagccatc ttttcgatat cctcggtagc
     9901 ctcttcctga ataacatcaa tagcgtcgtc aattgttacg ataccgacaa gtcggttttc
     9961 gttatcaaca acaggaagag caaggaagtt atagtttgag aacatctggg caacctgctc
    10021 ctgatcggca agagtagtta ccgagataac attttcctcc ataatcgacc ttacaagctc
    10081 gtcatcttcg gcaagcaaaa ggtcttttac ggtggtaata ccgataagct tgttgttggc
    10141 atcggttaca tagcaggtgt agattgtttc cttgtcaaca cctgttcttc tgattctttt
    10201 aatagccatt tcagccgtca tatcgggacg aagcacaata aactcggttg tcataatcga
    10261 gcctgcgctg tcctcgggat atttcaaaag ctcgttaatc tgctttctca tatccttgtc
    10321 ggcctgtctt aaaatacgct ttacaacatt ggcaggcatt tcctcaataa ggtcaacggc
    10381 gtcatcgaca aataactcat cgacaacctc tttcagttcg ctgtcgctga agccgtggat
    10441 aaggaattcc tgagtttcgt catccatttc gacaaaggtt tccgccgcaa gctcctttgg
    10501 cagaatacga aacagaatcg gcattttttc atcctgtaga ttttcaaaaa ccgccgcaat
    10561 gtcaaacggt ttcatcgtaa tcaaaatgtc acgcaaagtg ctgaactttt tgtcatcaag
    10621 caacactttg atagtttcgg taagggttac gttaacctgt tccatcatct tttcctcctt
    10681 tttaattcaa ttggaagtaa agacggtgtc accctgagta ttaaattaaa tcaattcaaa
    10741 ttaaaataaa aatacaaagc aaaatcaata aaacaaaatg aacgcacaag cgcacattct
    10801 gttgcaactt cgcccgggta cagcgccttt attaccgtct gcgtccatta agttttcacc
    10861 tcattcgcat ttaaattcgg acaaaagccc gtacatattt attttattct tttttatgtc
    10921 cgatgtcaac ggatttatcc gctaaaaatc cactttgcaa acattttaca ttatcctctg
    10981 taacagcttg gtaactcggt ataatatttc ttgctttttt aaatgtatca atgtataata
    11041 aatatgcatg atttaaaata aaatttcaaa gattggagat taaccgttat gacagatatg
    11101 gttaaaaaat atgttcccta tgcggtaata attttgcttg tttatatgct gttgccgctt
    11161 gtgtttattc cgggcgcaat gcagaagttt tcacccgttg catatgactg tgtgttcccg
    11221 attacggcaa tcggctgttc ggcacactac tgctcaaaac acggacttga cttcctcttt
    11281 gcactcattg cgccgattat ttatcttccg agtatgctca tctacaacgg cggattttct
    11341 tcaagcacac tttcaacaaa ccttattctc ctcgtagttt atcttgttgc cggaattttc
    11401 ggacttttcc tcggcgacct tgctttcggt gacaagcgcc gtcagaaaga aaaggcagaa
    11461 caggaggaag cggaggaaat gctccttgag gcaaagcgcc gtgaaaagga agagcttgag
    11521 aacatgactt catcaagcaa aaagtccgaa agaaaagcac cttacagaca ggaacgcaag
    11581 cctgcacgca aaccgtcacc tgcaccgcag aaaaccgaaa cagcagatga cgatgatttt
    11641 gattatgaca agtacctttc cggtattgac agaaagcaag atccgaacga aagcgaaatt
    11701 gacgatatct taaacgaata cagacactaa cggcgagccg ccgttcccgg ttcgtgcaga
    11761 tagtatttat aagggcgaaa ataaaatgcc cgagcggaac tctataacta aaaatgtaaa
    11821 attaaagtcg ggaagacaat ttgcaaaatg caaagcattg tcttcccgac tgtttttgtt
    11881 taatcagcag gggtgttcat cggacaccag ttttgattaa attttatgtt taaatatgat
    11941 tatgtgatgt tatggaagtt gtgtatgatt ttgtagggaa gaaccgtgtt ctcccgcacg
    12001 gcgagccgcc gttcccgatt cgtgtagata gtttgtaata taaaaaaaca tatcatgccc
    12061 gagcgtagca ttgcaatttt tcgcacaatc ccgtaggggc gttcattgga cgcccgccaa
    12121 gtaatgacag aaaatttatg ataaaaataa actgtataaa tgagatacag aattgcagtt
    12181 actttgtaac atttatatca tttaatttac aatattattt gtaccattat ttttgtttaa
    12241 atcaacccaa cgatatactt ctgaatcaag gttgcgtcaa caacactgat ttcgccgtca
    12301 tggtttacat cgctgttaaa aagctgagtc ttgccgaatt ttacaatacc tacaacatat
    12361 ttctgaacag atgttgcatc tacaaccgta atgtttccgt ctggatatgc atcaccgcaa
    12421 gtcaggcagt tcaatttgcc accaatcgtt gttttacact ctgcgccgtt tttaagtctg
    12481 caatatttat aagccataag gcccgtatcc tcgccaagct gtcttgaaat ataaaactcc
    12541 gcatagccgt tcttatcggg gacaaaagat gttaccgcac ctccgctgac aaaatatgcg
    12601 cccgaggttg catagcaagg tttgccgctg ctgtctgtac cgaaatcctc atatgtaaag
    12661 tcaaaattct tgtatgtgcc atcgctgagt tttccggtca ttgtgccatc atcattaaag
    12721 ccatcaggaa aatagtcgga gagtttaatc cttatcttaa catattctcc gcctgttgaa
    12781 tcataattga atttcatacc cgtatcacca aaataacgat tatccgctgt tatcatatgg
    12841 cgagtaaatt cctgattttt cgggagattt acaaacttcg gtgcatcaat acagtcctta
    12901 aacatcacgc tgtacttttg ataatccgtt gatatgaaca ttgccccgaa attctttgcc
    12961 gtattttcgg tatatcccgt tgttgtaaca aaaagctgat tgtttgagat tttctgcgtt
    13021 gtacctgtaa cttcaaagtc cttgcgatct tcatactcgc ttaccgcacc tgtcataaga
    13081 accgaaccga cggtaagcac accgcacatt gcgattgcag ttaatttttt gattatactt
    13141 ttcattgttt acacctattt atattgttca gctgtccaaa ccgacaatat acttctgaat
    13201 caaggttgca tcaacaaaat tgatttcgcc gtcatggttt acatcgctgt taaaaagctg
    13261 aagcttggca aagacctcaa tacctacaac atatttctga acaagcgttg catcagtaac
    13321 agaaatgtat ccgcttaaat ccgtatcacc gcaagttaag ccgaccagag tatctccgat
    13381 tcttccgtaa tcgcaatgag ctccgtcttt aagtctgcaa tagcggtatg acattacttt
    13441 tgtatctaca ccaagctgtc ttgaaacata tatttcagca tagccgtcct tatcgggagc
    13501 aaaggaggtt accgtacctc cgcttgttgc atatacaccg gattccgcat agcaattaac
    13561 accgttgctg tcagttccga aatcttcgta tgtaaaatca aaatccttgt aagaaccgtc
    13621 tctaagctca gcagtcattg ttccgttttc attgaacaga cgggaaaaat cggaaagctt
    13681 aattttcacc ttgacatatt caccgcctgt tttgtcaaac tgatagaatg tctgaacatt
    13741 accgaaataa ccgtgcccct gcgtcatcat atattttacg aatttttcgc cctttggaag
    13801 atttaaaaat ctcggtgcgt tgatacaatc tttaaaccat atatcgtaat ccttttcgtt
    13861 ggttgttctg aa
//
