LOCUS       c00120_gnlPro..        14690 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OKBNLKHF_120.
ACCESSION   c00120_gnlPro..
VERSION     c00120_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:15:10
            Original ID  :: gnl|Prokka|OKBNLKHF_120
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2089
            Orig. end    :: 16779
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14690
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[12089:15317]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14690
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14690
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             117..737
                     /locus_tag="ctg120_4"
                     /transl_table=11
                     /translation="LLWLYILLGIVLFIALVMFIPITLRASYKEKFWCAVYIGFVKLQL
                     VPAKPKKEKKKKKAKKQTQKTEQPKKATEKKLSLIKKYGIEWLLNLIKKVAELAVSALQ
                     DFFSHISVKKFSLSISVAGDDAADTAIKYGKYCAVVYPAVGTIVRVVKCKGYGVDINPN
                     FSEKAETEINFDFAAKIFAFRLIGLAVKHGIKGIKLLAEVKND"
     CDS             768..1187
                     /locus_tag="ctg120_5"
                     /transl_table=11
                     /translation="MEHPIGSLMDTTMEKIKEMIDVNTIIGEPITSPDGTLIIPVSKVS
                     YGFAAGGSDLPTKKENKDCFGGGSGAGVTIQPVAFLTVYQGDVRLVSVDREEGTADKLV
                     SMIPDVLKKVKGVFKKDKSESADDFSEITQDDIDG"
     CDS             1239..2363
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_6"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.5e-58, bitscore:
                     188.1, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIISLAVCFVMPFVLMGAKTAEDTPPTTSAQAFVLYCPDNNTV
                     ICSKNADEKMKPASTTKIMTSLITLEEAASCNSEVTFKQEMVAEGSSMYLKVGEKVRLS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMTNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENDDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLLLYPYCTGGK
                     TGYTTVAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKDSVTVTGEKNSTIVLKREDCDKIKKKIFIDRFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGEKIKSDKKSVSIFSAIGNLFS"
     CDS             2407..3156
                     /locus_tag="ctg120_7"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVRVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             3387..4700
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Btheta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_8"
                     /sec_met_domain="CT_Btheta (E-value: 1.3e-67, bitscore:
                     218.4, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFAKSGEGFA
                     EVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVGFYDSVGG
                     RLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIMSKDAQLS
                     LSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSFEEAPAED
                     GCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGKELGCKSANKVAKF
                     VRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSGYVALAGT
                     GANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLSAYNAAQN
                     GYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             4739..5104
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_9"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.1e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPATAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             5135..6538
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg120_10"
                     /sec_met_domain="HMGL-like (E-value: 1.2e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 2.3e-55, bitscore:
                     177.5, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPAFQKKIIGDKKI
                     IKGRPADQLEPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             6734..7411
                     /locus_tag="ctg120_11"
                     /transl_table=11
                     /translation="MKKFLTALIAFVMCFSVVTTAFAATPDEISESDVASEIRQVMIDT
                     YYGGKEPEYLSIEIVGSTSDGGVYFMHNEGFSLDYSIEEIIGDYTYHYNHNDDVMLYKN
                     GNVYSIKEAYESGVIDDSILEELSKMNFGLESNKPNTTVPTEPTTSVATVDEPVTVPDT
                     TSATSATKPVSTSNTATKDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRN
                     YFK"
     CDS             7608..9446
                     /locus_tag="ctg120_12"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVAVSAVSANAVEPLNTPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYVDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGTAVKYIAAPEISKLENVNGGVKISWGKVSGATKYRV
                     YYKGSKGWTRMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVA
                     TPKISKLEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFD
                     LSIDDIYYTVRCISKDAKSFTSGYDSKGTPIGDHQDCPEIYSIGAVNNGVEMHWTGDAP
                     KFRVYIKENGSWKKIAETYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYR
                     YKTSDKTRDAYINYMMNHQSEWMPSLGSEHNLSGVMFLDFDFDGVPELVAQKADSNEYS
                     FHSVVYKFEDGKLKRVGNVNDGFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITY
                     DGENLFANMYSARGVGEESNNNIYYRYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTE
                     FIATGYGDASVWGEKTTAENKQSLLDAYNSFSYEKY"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg120_13"
                     /sec_met_domain="IlvN (E-value: 1e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 7.7e-61, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYEGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg120_14"
                     /sec_met_domain="ALS_ss_C (E-value: 5.4e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg120_15"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3e-43, bitscore:
                     137.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHTNEEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(13425..14666)
                     /locus_tag="ctg120_16"
                     /transl_table=11
                     /translation="LKKIFLLLVTALFLLSLYGCNTSSSSNNPTEQTTVTNTDDLSLDS
                     DIETTELNHDFEIYNNGKKVDTLNLYGLFKQIDNGFIYSKINKDSPNEMEYYRYYFDKK
                     SSVKLGSIKDWSMQIHDKAYVNNHLCFTSSTGDITDEENRTLEFIDIDLNKNKMTTVFS
                     DKGGFPYDTVTGADNLVIITKVLDNGTSLELYDTETQKFKQLKYLEFDDKNSIGETIRK
                     VSIDKSTKTISLLVLDCISQNEASLKIETYDYDINFLKSYDISNISDESTELIQGGQDF
                     VFINNYLFYQNFSITRCIGYIDSDKLKKSDISEDVDDTFSIVSASEDDSDTNLLYKRAE
                     SSSENNYIYLFDTTNKTMKETKFNIEEKGYTIGGISRIGKDNLMILMSPDNADKKSDLN
                     SRIYFTKLSDLKFQ"
ORIGIN
        1 caaggagtcc gaagaaaacg gtgaagaaca ggaaaagact gaaaacggca acgagcagat
       61 tgatttgctt gccgaccagc ctgttgacag gcagtaaaat ttagggggaa ttccctttgc
      121 tttggctata tatcctactc ggaattgtgc tgtttattgc gcttgtgatg tttattccga
      181 ttactttgcg tgcatcatat aaagagaagt tttggtgtgc cgtgtatatc ggatttgtaa
      241 agcttcagct tgtgccggca aaacccaaaa aggaaaagaa gaagaaaaaa gcaaaaaaac
      301 aaactcagaa aaccgaacaa cctaaaaaag cgacagaaaa aaagctgagc cttataaaaa
      361 aatacggtat tgagtggctt ttgaacctga taaaaaaagt tgcagagctt gcagtatctg
      421 cattgcagga ttttttcagc cacatatcgg ttaaaaaatt ctcactgagt atcagcgttg
      481 caggtgacga tgcggctgac acggctataa aatacggcaa atactgtgcc gttgtttatc
      541 cggcagtagg cacaattgtc cgtgttgtaa aatgcaaagg ctacggagtt gacataaatc
      601 cgaatttttc ggaaaaagca gaaacagaaa ttaactttga ctttgccgca aaaattttcg
      661 cattccgact tatcggtctt gccgttaagc acggaatcaa ggggattaaa cttcttgcag
      721 aagttaaaaa tgattgatat aaatattgtt gaaaaaggag aatggctatg gaacatccta
      781 tcggcagttt aatggatacc acaatggaaa aaatcaagga aatgattgat gtcaatacta
      841 ttatcggcga gcctataact tcgcctgacg gcacactcat cattcctgtt tcaaaggtaa
      901 gctacggctt tgcggcaggc ggttcggatc tgcctaccaa aaaggaaaac aaagactgct
      961 ttggcggcgg cagcggtgca ggtgtgacaa ttcagcctgt tgcatttctt accgtttatc
     1021 agggcgatgt aaggcttgtt tccgttgaca gggaagaagg tacagccgac aagctcgtta
     1081 gtatgattcc cgatgttctt aaaaaagtaa agggagtttt caaaaaggat aagagcgaat
     1141 ccgcagacga tttttccgaa atcacacagg acgatattga cggctgattc gtaatattgc
     1201 aacacccctc ggcatagatt tatgcagggg gtgtccttat gaaaaaaata atctcgcttg
     1261 cggtgtgctt tgttatgccg tttgtgctta tgggcgcaaa aactgcggag gatactcctc
     1321 ccacaacttc tgcacaggca tttgttcttt attgtcccga caacaacacg gttatctgtt
     1381 caaaaaatgc agatgaaaaa atgaaacctg cgagcaccac aaagattatg acatctctca
     1441 taacgcttga ggaggcggca tcctgtaaca gcgaagtaac cttcaaacag gaaatggttg
     1501 ccgagggcag ttcgatgtat cttaaagtcg gtgaaaaagt ccgactttcg gaccttgcgt
     1561 caggaatgat gatggcgtcg ggtaatgatg cggcgaatgc ggcggcatat acgatttcgg
     1621 gcagtcccga aaagttttca caacgaatga atgaaaaggc aaagcaaatc ggtatgacga
     1681 ataccaattt tgtaacgccg agcggacttg acgatgacaa ccattactca agtgcaaagg
     1741 atatggctct gcttatgtca tatgcacttg aaaatgacga ttttgcaaat cttacggcta
     1801 agaagagcgt gaccgttgaa ttccttgaac cgaaatcaaa gaaaaccgca tatgcaaatc
     1861 ataacaggct tttgttgctt tatccctact gtacaggcgg aaaaacaggc tatacaacgg
     1921 tggcagggcg gtgtcttgtt tcctctgcaa aaaaagacgg tgtaacgctt gtgtgcgtca
     1981 ctctgaatga ccgcaacgac tggaatgacc atatttctct ttatgattac gcttttgaaa
     2041 agtacagggg agttgactgc aaggacgctg acttttgtgc cgatattccg tgcgtgggcg
     2101 gtgataagga cagcgtaacg gttacaggcg agaagaacag cacaatcgtt ttaaagcgtg
     2161 aggactgcga taaaatcaag aaaaaaatct tcatagacag atttttgtat gctccgattg
     2221 aaaagaacga atcggtcggc agaattgaat acacgctcgg cggaaagctg ctttataaat
     2281 gcaacattgt tgcaggcgaa aagattaaat cggataaaaa gagcgtgtca atattttcgg
     2341 caataggaaa tctgttttcg taacagctta aatataaaga aaattttaat aaaaaggaat
     2401 ttacatatgg ctaaaattga acctataaga cttcagaaat tcatagcgca atgcggtatt
     2461 gcgtcaagga gaaaggccga ggagcttatt ctcggcggtc atgtcaaggt gaacggcaaa
     2521 accgcaattc tcggcgataa ggttcttcct acagacaagg tgtttgtaag aggcaagagg
     2581 attgttgtgc cgaagggcgg taattaccga tatattatgc tcaacaagcc ccgtggattc
     2641 attaccacaa tgaatgatga gcgtggcaga aagtgtgttg cacagcttgt tgagaatgtc
     2701 ggcgagcgag tttatccgat aggcagactt gacaaagaca gcgaaggtat gcttgttttt
     2761 acaaatgacg gtgactttgc aaacaaggtt atgcacccga aaaacaatgt ttacaagatt
     2821 tacagagtaa ccgttcgacc gtcaattgac gaggatcagc ttgtaaagct tgaaacaggc
     2881 gttgagcttg atggcagaaa aaccgctcct gcatatgtcc gtgtgattca caaggagcag
     2941 ggcagagtag ttcttgaaat gattcttcac gagggtaaga accgtgaaat cagaagaatg
     3001 tgcgaggctg tcgggcttga ggttgcaaga ctcaaacgca cccagatcgg cggagtaaaa
     3061 atgggtatgc tcaaacaggg cgactggaga gatttgaccg aacaagaggt taaaaaactg
     3121 cttgcaaacc cgtttttaaa cggcaaacag ctttaatttt ccgtttttga aaaatacttc
     3181 cgaaacggtc aatcaaacta tttgttaatt cgacaataaa ttaaaggttt tcacggaata
     3241 actattaaat gtgttcaaaa ttgaaatagt acagcgtgtt tttcttgtac ttttgaagat
     3301 tatagagtat aatgtattgt gtagaaaatt agtatgcacg ctcagttttc gtgcatattc
     3361 aatacatggt attggaggat tttaagatga gtattgaaaa gatcaatcag gcaaaggctg
     3421 aaattgccgc aacttccgct tataagacaa ttacggcgtt ttttgatgca gacagctttt
     3481 gtgaaattga tgcctttgca aaatccggtg agggttttgc cgaggttgtt gcaggctttg
     3541 gaacagtaga aggtatgcct gtttatgcgt ttgcacagaa cagcgacatt tgcggcggtg
     3601 ccatgagtaa ggcacaggct gccaagctta aaaagctgta tggtcttgca ctcaagacag
     3661 gcgctcctgt tgtaggcttc tatgacagcg ttggcggcag acttaatcag ggtacagagc
     3721 ttctcgcagg ttgcggtgat gttctcaatg cggctgcgtc actttccggt gttgtaccgc
     3781 agatctcggt tgttctcggc acttgcctcg gaacaaacgc tcttaacgcc gcaagcgcag
     3841 acatcgttat catgagcaaa gacgcacagc tttcactttc tgtaacaggc aagcattccg
     3901 atgccgctta caatgctgaa aacggtattg cctcaatcgt ttgtgacgat gcagacaagg
     3961 caatcaaggc tgcaaaggaa cttatccttt atcttccgtc aaataacctc acaatggctc
     4021 ctcagtcatt tgaagaagct ccggcagagg acggttgcgg ttgtgtagtc agcagaacag
     4081 ttgacggcaa tagcattgta aagctcttca atgattacgg caaggaagca aatgttcgtt
     4141 ttgcaagact cggcggtcag gttgtaggta ttgttgttac aaagggcaag gagcttggtt
     4201 gcaagtctgc aaacaaggta gcaaagtttg ttcgtttctg cgacgctttc tcactccctg
     4261 ttgtaacatt cgtaaactgc ccgggctttg agtcaatcaa gtcggcaaca aaggcatcag
     4321 ccgcttatgc tgaggcaaca acagtcaaga tttctgttgt tacaggcaag gcaatcggtt
     4381 caggctatgt tgctcttgca ggcacaggcg ctaatgcaga tgttgtttac gcacttcccg
     4441 atgcggttat ttcacctgtt aatgttgagg ctgccgcatt cattatggct cccgaagtta
     4501 tgaatgttgc cacagataag caggctgagg ttgctcagaa gtttgctgac gagaatcttt
     4561 ctgcttacaa tgccgctcag aacggctatg ttgacggtat tgttgaagaa gctcagctcc
     4621 gtcagactct tatttctgct cttgatatgc tctcgggcaa gcgtgtttca acactttcaa
     4681 agaagcattc aactatctga taaatgatta cttgttaaaa taaaagggga tactaaaaat
     4741 gaagaattta agaattacag ttaacggcac agcatatgat gttcaggttg aagaactcgg
     4801 tggttcttca gctcccgcag cagcagctcc tgctccggca accgctcccg ctcctgccgc
     4861 aaagccggca gctcccgcag gcgctcaggg ttccgttgtt gtaaaggctc ctatgccggg
     4921 tacagttgtt aatgttgttg tttcggcagg acaggctgtt aaggctggag atgacctcgt
     4981 atttatcgag gctatgaaga tggaaactcc cgttaaggct ccgcaggacg gcacagttgc
     5041 aacagttgat gttgcaaagg gtgagtctgt tgactccggt aaggttctcg taacacttaa
     5101 ctaatcaata attcggagaa agggatgctg taaaatggca aaaaaaatca gagttaccga
     5161 aactgctctg cgtgacgctc atcagtcact cattgcaaca agaatgacaa cagaggaaat
     5221 gctccctgtt cttgacaaac tcgataaaat cggttattac tcactcgaat gctggggcgg
     5281 tgcaacatat gactcatgcc tcagattctt aaacgaagat ccgtgggaca gactccgcac
     5341 aatcagagag cattgcccta acacaaagct ccagatgctt ttcagaggac agaatatgct
     5401 cggttatcgt cactatgccg atgactgcgt tgagtacctt gttcagcgtt caatcgcaaa
     5461 cggtattgac attatccgta tttttgatgc tcttaacgac atcaagaatc ttaaaacagc
     5521 tatcaaggcc gctaacaaag aaggcggtca tgcacaggtt gctatcagct acacaacagg
     5581 tcctgtattc acagatgaat actatgttga gtatgctaag agaattgcag acgcaggtgc
     5641 agattcaatc tgtatcaagg atatggctgc acttcttact ccgacaagaa ccgaaagcct
     5701 tgtaaaggct atcaaagccg ctgttccgga gcttccgctt cagctccaca cccactacac
     5761 atcaggtctt gcatcaatgt gtcttttaaa gggtgttgag gcaggtgccg acggcattga
     5821 cacagcaatc agtccactcg ctctcggtac atcacacgca cctacagagt caatggttgc
     5881 cgctctttca ggcacagagt tcgacacagg tcttgacctt aaacagttct ctgacatccg
     5941 tgcttacttc atgactcttc gtgagaagta catcaagtca ggacttcttg atcctaagat
     6001 gctcgcaaca gacgctaacg ctcttatcta tcaggttccc ggcggtatgc tttccaacct
     6061 tctttcacag ctcaagcagg ccggtaaaga agacaagctt gacgaagttc ttgcagaagt
     6121 accccgtgtt cgtaaggatt caggttatcc tccgcttgtt actccgacat cacagattgt
     6181 cggcacacag gctgtattca atgtaatcac aggcaagcgc tactcaatgt gcacaaacga
     6241 gttcaaggga cttgttgccg gtgagtacgg tacaactcca atgccgattg atcctgcgtt
     6301 tcagaagaag attatcggtg acaagaagat tatcaaaggc cgtcctgcag atcagcttga
     6361 gcctgagctt gataagctcc gtggcgagat tgagcagtgg attgaacagc ctgaggatgt
     6421 tctttcttat gcacagttcc cgaaggttgc tctcgacttc tttgaaaaga gaagaaatgc
     6481 caaggttggc atcaacggcg acaagcttga caagaaaaat atggttcacc ctgtttgatt
     6541 tgacaactaa aattaacatt tatgccactt tcaactatgg aagtggcatt tttatttgaa
     6601 cagaattttt tttgctgaat tttcatcaac tatattgcat tacatatatt ttagtggtat
     6661 aataaagtaa attaaatatc tgttgcgtat accattatta cagatagaat aaataaaagg
     6721 tgaggaaata aaaatgaaaa aatttttaac agcattgata gcatttgtaa tgtgcttttc
     6781 ggttgtaaca acagcttttg cggctacacc tgacgaaata tcagaatcgg atgttgcatc
     6841 agaaatcaga caggtgatga tagatacata ttacggtggt aaagagcctg aatatctcag
     6901 cattgaaatt gttggttcaa caagtgacgg cggagtatat tttatgcaca atgaaggctt
     6961 tagccttgat tattcaattg aagaaataat tggtgactat acttatcatt acaaccataa
     7021 cgatgatgtt atgctttata agaatggcaa tgtttactca attaaagagg cttatgaaag
     7081 cggagttatt gatgatagta ttcttgaaga attgtcaaaa atgaattttg gtttggaatc
     7141 taataaaccg aatacaactg ttcctactga gcctacaact tcggttgcaa cagttgacga
     7201 acctgtaaca gtacccgata caacttctgc aacttcggca actaagcctg tttcaacaag
     7261 caacacagct acaaaggaca caccgaacaa ttcacagaat aacagcggtg ctgtacagac
     7321 aggacagaac agcgttgctg taattcttct tgttgcaatg cttgcaggtt gtgcagtaat
     7381 ttttgcaaaa cgcagaaatt attttaaata attcaaaaca tcaacagaat atataaaata
     7441 aaccgttctc gcttttgtga acggtttatt tattttagct taaaaatttg tgatagttta
     7501 tcaagatgta ttgcttttta tatcatttaa tgttacaatt aacttgcata aaaatttagc
     7561 aaaagttctt aataatgcgt agaatattta caaagcgagg gatagatatg aaaaagtttt
     7621 tacctatagc catggcggcg gtaatgtcga tgtctgcggt tgcggtttcg gcagtttctg
     7681 caaatgcggt tgaaccgcta aacacacctg tgcagtatgc acaggttgca agggcaagct
     7741 tggcaacacc gaaaatttca aaagccgaaa gtgtttacgg tggtgtaaag cttacatgga
     7801 acaaagtgaa cggtgcggct aaatacagag tttactacaa gggccgtaaa ggttggacac
     7861 gaatggttga tacaacttca acctcatatg tcgacaagga tgtttcatcg ggcaggaatt
     7921 acacctatac tgtaagatgt atttctgctg acggaaagag ctttacaagc ggttatgatt
     7981 caaagggaac agccgtaaaa tatattgccg cccccgaaat ttcaaagctt gaaaatgtaa
     8041 acggcggtgt aaaaatctct tggggcaaag taagcggtgc aactaaatac agagtttact
     8101 acaaaggcag taaaggctgg acacgaatgg tcgatacaac ttcaacctca tatatcgaca
     8161 aggatgtttc atcgggcaga aattacactt atactgtaag atgtattaca tcagacgcaa
     8221 agaaattcac aagcggttat aacccgacag gcaagtcggt aaagtatgtt gccacaccga
     8281 aaatttcaaa acttgaggtt acatatgacg gtgtaaagct gacatggaac aaggtcgcag
     8341 gtgctgaaaa atatcgtgtg tactacaagg acagaaacgg ttggacaaag cttgccgata
     8401 caacaggcac gactatgctt gatatgaatg ttgtttcaaa ggaatttgat ttaagcattg
     8461 atgatattta ttacacggtt cgttgtatca gcaaggatgc caagagtttt acaagcggct
     8521 acgattcaaa gggtacgccc attggcgatc atcaggattg tcccgaaatt tacagcattg
     8581 gtgcagtaaa caacggtgtt gaaatgcatt ggacgggaga tgcgccaaag ttccgtgttt
     8641 atattaaaga aaacggttct tggaagaaga tagcagaaac ttatgacaac tattatgttc
     8701 acaagggtgc aaagtccggc agtaacactt atacggtaag aggtgtttca aaagacggta
     8761 aaaagtttac tacgatgttt aacccaaccg gtgtaacata cagatataag acatccgata
     8821 aaacaaggga tgcttatatc aattatatga tgaatcatca gagtgaatgg atgccaagct
     8881 tgggaagtga acacaatttg tcaggtgtta tgtttttgga tttcgacttt gacggagttc
     8941 cggagcttgt tgcacaaaag gctgattcca atgagtatag tttccattcc gttgtttaca
     9001 aatttgaaga cggtaagtta aaaagagtgg gaaatgttaa cgacggtttt gcgatatact
     9061 ataataaaac tgccaaaaag tatgaggttc acgacctaaa gatatcttta aatgtagatg
     9121 acggttacta ttggtcgggt aattcaataa tcacatacga cggagagaat ctttttgcaa
     9181 atatgtattc ggcaagaggc gtaggcgaag aatcaaataa taatatttat tatagatatt
     9241 ttgacggtaa tgacaaaaat atttcacggg caaaatataa cgaaattaac cttaaacagt
     9301 ttaataattg cgtaaatgca catatgttta ccgaatttat tgcgacaggt tatggtgatg
     9361 ccagcgtatg gggtgagaaa actaccgctg agaataagca gtctttgctt gacgcatata
     9421 attctttctc ctatgagaag tattgattat ttaaaaattg ataagtttta actgcaaaag
     9481 ggttcagccg taaaaagctg aaccctgatt ttttaaatgg aaaatgaaaa gcagaaagtg
     9541 gaaaattata aatttcagac gggagattat tacccgcccg caagtaatgg cacaaaacaa
     9601 tttacaaatg taattttata aatgtcgcaa tgtgattgtt ctactgtagc ggcgaaccgt
     9661 gttcgccaat cggtttgttt gcaaaaacaa accgaacata tacacagctt ttgttatatg
     9721 aaaatgatat attaataaac gaatagtttg tgttgagtcg aaccgatttt acaatcggtt
     9781 cgattggcga acgaggttcg ccgctacgga ttatcagtaa atttgtgatt tttatataat
     9841 tggatttggt atcgaattta tgcctttact tgccgacgaa tacagtgcgc ccctacaaaa
     9901 aacggttcag ccaaattgac tgaaccgtta atttatacta tgtaatgttc gggtgaccga
     9961 agtttgaata tatcaaactg tcttcacgaa ctaaaaaaca ttagttgttg atgagcttat
    10021 cctcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cagcagcgag ctttctcata gccttgaagt gaacctgtga acctgcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcat ttcttgggtc gtaaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcacaaa caccgccgca aagaacagcc tgttcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacgccggct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagcg tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgaccag
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagcg aacataagca tattgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttgta aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgccgat gtatatacct taaagccctg agcttcagcc tttgcccagc
    10861 tcttgctacc ttcgtaaaga ccgatgatta catcgcaacc tgaatccttg aggttgagag
    10921 cgtgtgcatg accctggctg ccgtaaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttgca atctgactga tagtagattg gtgctgtcat gttctttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta gaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt caatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gacgcggctt gcgcattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat tttcgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcgcagtg aaccttgatt aaaacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacctt aataacggga atgagcttgt
    11401 tgagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cgggtcctga gtaacaccta ctgcaagcga gtcgatgtta aagcctcggc
    11521 gagagaaaag tcccgaaatc tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttcc gaatcaacaa tacccttgat gatgttttcg gcttcctcgt
    11701 ttgtatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgcg gagtgtctgc caccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tagtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacgt
    11941 cacggtcggg tcttgcaaac tttgcaccga ttgcagcggg aattgagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacatcg gcaacaagaa ttgccttcga gcggaacatt gcgctgagat
    12121 gaccgacaag tgttctcggc tcaacaaagc cgtcaaatac gggaggctca cggtaaaggt
    12181 cttttttcca gttctttacg gtttcgctcc acattgttgt aaccttgtaa tcgccgatac
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tctgttttaa
    12301 cattcttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agccgcaaca gctctgtcac cgagtcttgc accgcatacg attacaaggt
    12421 cggcttcgtg aagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaactcagc acgccgccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttagtgttc ggcttgtaac cgataatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc tgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggttgca atgcctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgaatc gtaaacttta tcgtaaaatg
    13141 ggcaaatagc cgcaccggga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct ttttattgtg
    13261 agcaaaaggt gttttgtaac attaaatata cctttttact ttaccgctaa ttatacaata
    13321 aataccttaa aaagtaaaga gcagtattgc ccataaatta aattttttgc aggattttga
    13381 cagataattt gcaaaatgga ttttaattga tttttaccgc ctgtttactg aaattttaag
    13441 tcgcttagtt ttgtaaagta tattcttgaa ttaaggtcac tttttttgtc tgcattatca
    13501 ggggacatca atatcatcaa attatctttt cctatccgtg atataccgcc tatagtgtac
    13561 cctttttctt caatattaaa ttttgtttct ttcattgttt tgttggttgt atcaaaaaga
    13621 tatatgtagt tattttctga acttgattcc gccctcttat acaataaatt tgtatcactg
    13681 tcatcttcag atgcggatac tattgaaaaa gtatcatcta catcttctga tatgtcggat
    13741 tttttcagct tatcgctgtc tatatatcct atacatcttg ttatgctgaa attttgatag
    13801 aatagataat tgtttataaa aacaaaatcc tgtccgccct gaattaattc ggtggactca
    13861 tctgaaatgt tggaaatatc atagcttttg agaaaattaa tatcatagtc ataagtttct
    13921 atttttaaag aagcttcgtt ctgtgaaatg caatccaaaa ccaaaagaga gattgttttt
    13981 gtacttttgt caattgaaac ttttcttata gtttccccga tactgttttt atcatcaaac
    14041 tctaaatatt ttaattgctt gaatttttga gtttcggtat catacagttc caaagaagta
    14101 ccgttgtcta gcacttttgt gattatgaca agattgtctg ctcctgtaac agtgtcatat
    14161 ggaaatccgc ctttgtcaga aaatacagtc gtcattttgt ttttattaag gtcgatatca
    14221 ataaattcaa gagttctgtt ttcttcgtct gtaatgtcgc ccgtgcttga cgtaaagcaa
    14281 aggtgattat ttacataagc tttatcgtga atttgcatag accagtcttt tattgagccg
    14341 agttttacac tgcttttttt atcaaaataa tatctgtaat attccatttc atttggagag
    14401 tctttattga tttttgaata tatgaagccg ttatcaattt gtttaaataa gccgtaaaga
    14461 tttaaagtat ccaccttttt gccgttattg taaatttcaa aatcatgatt taattctgtt
    14521 gtttcaatat ctgaatcaag agataaatca tctgtattcg ttacggttgt ttgttcagtg
    14581 gggttattgc ttgatgaaga agtgttacac ccgtataatg aaagtaaaaa taaagcggtt
    14641 actaataata aaaatatctt tttcaaatta atctctccga agtttattta
//
