LOCUS       c00048_gnlPro..        11154 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMDFOPOP_48.
ACCESSION   c00048_gnlPro..
VERSION     c00048_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:21:22
            Original ID  :: gnl|Prokka|OMDFOPOP_48
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11154
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11154
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2449:5677]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2450..5677
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11154
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11154
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             53..2149
                     /locus_tag="ctg48_1"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETDGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPEITKKKINHGTIFLAISIVLAV
                     VSEILHLTLDGVTAVHYVVLAACFVATLLSGYKVFIKGAKNILKLKIDETTLMAVAVIA
                     AFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIRPDTATIIVDGAEKIVPA
                     ESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPVDAGEGSEVLSGAINGSN
                     LITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASVYTPVVVLIAAAIAVIPP
                     LCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAASEVGVLIKGGKYIEALAK
                     ADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEKYSAHPIASAIREKANGL
                     ELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIANKDDSVFVIYDGQLIGSL
                     NVSDTVRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNELGLSECHAELLPAQKLE
                     LFKGLKSKSKGACFVGDGINDAPVLSASDCGIAMGFGSEAAIEASDAVLASGTLKQLPK
                     AIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVIADTGVSVVCVLIAARLL
                     KKKY"
     CDS             2450..4072
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKIYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             4085..4576
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_3"
                     /sec_met_domain="ALS_ss_C (E-value: 2.4e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             4637..5677
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_4"
                     /sec_met_domain="IlvN (E-value: 4.3e-84, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.4e-61, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(5978..7816)
                     /locus_tag="ctg48_5"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVAVSAVSANAVEPLNAPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGTTVKYIAAPEISKLENVNGGVKISWGKVSGATKYRV
                     YYKGSKGWTKMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVA
                     TPKISKLEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFD
                     LSVDDIYYTVRCISKDAKSFTSGYDSKGTPIGDHQDCPEIYSIGAVNNGVEMHWTGDAP
                     KFRVYIKENGSWKKIAETYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYR
                     YKTSDKTRDAYINYMMNHQSEWMPSLGSDHNLSGVMFLDFDFDGVPELVAQKADSNEYS
                     FHSVVYKFEDGKLKRVGNVNDGFSIYYNKTAKKYEVHDLDIYLNVDEGYYWSGNSIITY
                     DGENLFANMYSARGVGEESNDNIYYRYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTE
                     FIATGYGDASVWGEKTTAENKQSLLDAYNSFSYEKY"
     CDS             complement(7835..9481)
                     /locus_tag="ctg48_6"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVAVSAVSANAVEPLNTPVQYVQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGSKGWTRMVDTTSTSYIDKNVSSGRN
                     YTYTVRCISKDGKKFTSGYDSKGKSVKYVAAPKISKVESVYDGTKITWNKVTGAEKYRV
                     YYKDRTGWNRLVDTTGTSVVDEGLYPAEYNISQGVANTIYTVRCISKDGKSYKSGYDSK
                     GKALTGYKQSIPDVRNISTVSGGIKLEFNYALPENSKYRIYRKENGSWKKLAETYNQYY
                     TDKNVKAGKIYTYTVRGVSKNGKKFTSSYNPSGVTLKYKTTNKTRDEFVNYLMNNQNKW
                     LPHDYGVGMMAQSGFQFIDLDFDNVPELVVQETGGTMCNFDAKVYSFRNGKLVQAQYNE
                     NYIQNRLRMYYNKSSKKYEIFGTSILAAGTMNDHSYGQFQLKYNGSTITTDYFGMFYVA
                     YPMNTASGNYEYTYYNGIGGYYSGAGNYKKISKSTYNDIMRSKFTNLVNVHMYSQFIYQ
                     TATDTNWNNMSYSQRKQALLDSYDSFSYDKY"
     CDS             complement(9500..11152)
                     /locus_tag="ctg48_7"
                     /transl_table=11
                     /translation="GIDMKKFLPIAMAAVMSMSAVAVSAVSANAVEPLNTPVQYAQVAR
                     ASLATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSS
                     GRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVATPKISKLEVTYDGVKLTWNKVAGAEK
                     YRVYYKDRTGWNRLVDTTGTSVVDDGLLVSEGSTFENRRVSYTVRCISGDGKKFVSGYD
                     SKGKTAVDGQYHPNIQNISTVSNGIKLDFNNALTSNSKYRIYRKENGSWKKLAETYNQY
                     YTDKNVKAGKSYTYTVRCVSKDGKKFTSSFNPSGVTLKYKTTNKTRDDFVNYLMNHQNE
                     WLPSNYDSGLVVAHSGFEFTDLNFDGVPELIVQESGGTMRNYDARVYSFKNGKLVKAQY
                     DENVIQNRLRIYYNKSSKKYELFGTACSSSGLFHDLGQSQFQFKYDGIKVTTDYFAAYY
                     MEGKFGEHTSQMDYTYYKGLKGYYASSDNIKEISKSNYNDILRSRFANRVNAHKRSQFI
                     LRVNTDKCWNKMSYSQRKQALLDSYDSFSYDKY"
ORIGIN
        1 acgaatcata gaaatgggac ttgaccatgt tcttgaataa ggagggagac atatgaggta
       61 caaatatcag cttgacaatc tcaactgcgc tcattgtgca ggcaagattg aggctaaaat
      121 tgcagaaaca gacggttttg aagatgtgag cttcaatttt gcgacaaaac ttctcaactt
      181 caaaagcgaa aagcagaatc ctgtttccga aattcaggcg atctgcgaca gcattgagga
      241 cggtgtaact gttgttgaca aaactccgaa aaatgatatc acaacaaagg cagaacccga
      301 aatcacgaaa aagaaaatca accatggcac aatcttcctt gcaatttcaa ttgtacttgc
      361 tgtagtgtcc gaaattctcc accttacact tgacggtgtt acggctgttc attatgttgt
      421 actcgcagcg tgttttgttg caacacttct ttcgggttac aaggtattca tcaagggtgc
      481 aaaaaacatt ctaaagctga aaattgacga aacaacgctt atggctgttg cggtaattgc
      541 ggcattctgt cttggagatt ttgttgaggc tgcaatggta acaatcctct tttctatcgg
      601 tgaaattttt gaggatcgag cagttgacgc atctcgccgt gacattgaaa agcttgcaaa
      661 cattcgtccc gatacagcaa caattattgt tgacggtgcg gaaaagattg ttcctgccga
      721 aagcgttgaa atcggaagta tcattgaagt caagccatac gaaagagttc cgcttgacgg
      781 cattattatt aaaggtaaaa cgactctcga cacatcggct ctcacaggcg aaagccttcc
      841 tgttgatgca ggcgagggca gtgaggtact cagcggcgca atcaacggca gtaaccttat
      901 taccgtcaaa accacaaaac atttcggcga cagtaccgca acaagaattc ttcagcttgt
      961 tgaagatgcc gccgctcaaa agggcaacag cgaaaagctt atttcaagat ttgcctctgt
     1021 ttacacaccg gttgttgtac tcattgcagc tgcaatcgca gtaattcctc cgctttgcgg
     1081 actcggagct ttcagcgaat ggctataccg tgcgcttgtt tgtcttgtag cgtcatgtcc
     1141 gtgtgctatt gttatttccg tacctctctc ctactattcg ggtatcggtg cggcatccga
     1201 agtcggtgta ctcatcaagg gcggaaaata tattgaggct cttgcaaaag cagacacatt
     1261 cgtattcgat aaaacaggca cgctcacaag cggcaagctc agcgtaaaca aggttaatac
     1321 tgtcggttca tacagtgctg acgaagttct tgctcttgcc gctgcaagcg aaaaatattc
     1381 cgctcatccg attgcctccg caatcagaga gaaggcaaac ggtcttgaac ttcccgagct
     1441 ttccgactac agcgaaagtg ccggtcacgg aacaagcgca gtttacaacg gcaaaactat
     1501 tcagtgcggc ggttcaaaga ttctttcgga cgaacagaag aagattgcaa ataaagacga
     1561 ttctgttttc gtaatttatg acggtcagct tatcggttcg ctcaatgtca gcgatacggt
     1621 aagacctgag gcaaaagagg ttatctcaca gcttaaagcg ctcggtgtca agaacacggt
     1681 aatgctcaca ggcgacagac aacagcctgc cgaaaatgtt aaaaacgaac tcggactttc
     1741 cgaatgtcac gcagagcttc tccctgctca aaagcttgag cttttcaagg gcttgaaatc
     1801 aaaatccaag ggtgcttgct ttgtaggcga cggcatcaat gatgcccctg ttctttcggc
     1861 aagcgactgc ggtatcgcaa tgggattcgg cagtgaagcc gctattgaag cgtcagacgc
     1921 agttcttgca tcaggcacac tcaaacagct tccaaaggca attaaaattg caagaagtgt
     1981 tatcaacact gtcaaaggca acatcatctt cgccctctca atcaaggctc ttgtaatcat
     2041 cctcgccgca ttcggtcttg cacaaatctg gatgtccgtt atcgccgaca caggcgtcag
     2101 cgtagtctgc gtcctcatag ccgcaagact cctcaaaaag aaatattgat tttctcaaca
     2161 atcattactg ttcccgagca ggtaaaactg ttcgggaatt ttcttgttat tactcttata
     2221 cagatacttt tttggtcagc attttgcttt tgttgttaat catttattat atctttttca
     2281 ggcgatgaca gaataattta aaatcctgca aaaaatttaa tttatggtca atactgctct
     2341 ttacttttta aggtatttat tgtataatta gcggtaaagt aaaagggtat atttaatgtt
     2401 acaaaacacc ttttgctcac aataaaaagg ataggaggga caaaacataa tgatcagcgg
     2461 tgctgaaatt atggtaaaat gtttggaagc cgagggcgtt gacatagtct ttggttatcc
     2521 gggtgcggct atctgcccat tttacgataa aatttacgac tcgagcatta cccacattct
     2581 tgttcgtcag gaacagaacg ctgctcatgc ggcaagcggc tatgcaagat gcagtaatcg
     2641 tcccggtgtt tgcgtggcaa cttccggtcc cggtgcaacc aacctcatca caggcattgc
     2701 aaccgcctat acggactcta ttccgattgt tgccattaca ggtcaggttc gttccgacct
     2761 tctcggcaga gatgtctttc aggaagctga catcacagga gcttgtgaac cgtttgtaaa
     2821 gcacagttat ctcgtcagca aaacagaaga ccttccgaga gttttcaaag aggctttcca
     2881 tattgcctca accggcagac ccggtcctgt acttatcgac attcccgttg atattcagga
     2941 aaatgaaatt gaaagttttg aatatcccga aagcgtaaac attatcggtt acaagccgaa
     3001 cactaaggga cacgcaattc aggttaaaaa ggctgttgag gccatcaacg caagcaagcg
     3061 tcctgttatc gtatcaggcg gcggcgtgct gagttcgggt atcaagctta aacttcaaaa
     3121 atttgcagaa actacgggta tccccgttat ttcaactatg atgggcatcg gtgttatgcc
     3181 cagcgagcat gagctttatc tcggaatgct cggcactcac ggcaaggctg ttgccaaccg
     3241 tgctcttcac gaagccgacc ttgtaatcgt atgcggtgca agactcggtg acagagctgt
     3301 tgcggctccc gaccagatga gtgaaaacac aaaggtaatt cacattgaca ttgaccctgc
     3361 tgaaatcggt aagaatgtta aaacagaaat tccgattgta ggcgatatga aaaatgtcat
     3421 caatatgctg cttgacagca tcggcgatta caaggttaca acaatgtgga gcgaaaccgt
     3481 aaagaactgg aaaaaagacc tttaccgtga gcctcccgta tttgacggct ttgttgagcc
     3541 gagaacactt gtcggtcatc tcagcgcaat gttccgctca aaggcaattc ttgttgccga
     3601 tgtaggacaa aatcaaatct ggtgtgcaaa caacttccgt attcgtgagg gcagattcct
     3661 cacaacaggc ggtatgggta caatgggtta ctcaattccc gctgcaatcg gtgcaaagtt
     3721 tgcaagaccc gaccgtgatg ttattgtaat ctgcggtgac ggcagttttc agatggggct
     3781 taatgagctt gcgactattg caggcaatca gctcggaatt aaaatcatca ttatgaaaaa
     3841 cgcacgactc ggaatggttc gtgaacttca ggacaaacac tacggcggca gacactccgc
     3901 aacaattctc aacggtgatc ccgacttctt gaagattgcc gatgcttacg gcattgacca
     3961 tgcagaggct cattcaaaca aggaagccga aaacatcatc aagggtattg ttgattcgga
     4021 aaaaccgttc attcttgttt gcgatgttca ccccgacact ccgtcaattt aatgaggtga
     4081 taaaatgcag tatacattat caatacttgt tgaaaatcag gcgggcgttc tttcaaagat
     4141 ttcgggactt ttctctcgcc gaggttttaa catcgactca cttgcagtag gtgttactca
     4201 ggacccgtcg gtttcccgaa tcacaatcgt tgcaaacggt gacgagtaca ttgttgaaca
     4261 gcttgaaaaa cagctcaaca agctcattcc cgttattaag gtaaaaaggc ttaacgaggg
     4321 cgaattcatc agccgtgagc ttgtattaat caaggttcac tgcgccgcct caaaaagagc
     4381 cgaaattgtc aaaacggttg aaattatgca ggcgaaaatc gttgatgtat ccccttcgtc
     4441 agttaccgtt gagtactgcg aatgcgcaag ccgcgtcaac acgcttgttg acttactcaa
     4501 gccttatggt atccgtgaga ttgtaagaac aggtactgtt gccattgaca gaggcacagc
     4561 ttcggtttcc gtttaatctt acagttagca tatattttaa tttatatgcc gcgtttgcgg
     4621 taaggaggac tttaatatga aagactacac aaaaaacatg acagcaccaa tctactatca
     4681 gtcagattgc aaccttgacc ttctcaaggg taagaaaatt gctattatcg gttacggcag
     4741 ccagggtcat gcacacgctc tcaacctcaa ggattcaggt tgcgatgtaa tcatcggtct
     4801 ttacaaaggc agcaagagct gggcaaaggc tgaggcacag ggctttaagg tatatacatc
     4861 ggcagaggct gcaaagcagg ctgacatcat catgattctt atcaacgatg aaaagcaggc
     4921 agctctttac aagaacgaca tcgagccaaa cctcgaagca ggcaatatgc ttatgttcgc
     4981 tcacggcttt aacattcact tcggttgcat caagcctcca aaggatgttg atgttacaat
     5041 ggtagctcct aagggacctg gtcacacagt tcgttcagag tatcaagttg gtaagggtgt
     5101 accttgcctc gttgctgttg agcaggatgc tacaggtcag gctaaggatc tcgcacttgc
     5161 atatgcactc ggtatcggcg gtgcaagagc cggcgttctt gaaacaacat tcagaacaga
     5221 aacagaaaca gacctcttcg gtgagcaggc tgttctttgc ggcggtgttt gtgcacttat
     5281 gcaggcaggt tttgaaacac tttgcgatgc cggttacgac ccaagaaatg cttactttga
     5341 gtgtatccat gagatgaagc tcatcgttga ccttatctat cagtcaggtt ttgcaggcat
     5401 gagatattca atctctaaca cagctgagta cggtgactac atcacaggtc caaagatcat
     5461 cacagaggat actaagaagg ccatgagaaa ggttctttct gacattcagg acggtacatt
     5521 tgctaaggac ttcctccttg acatgagcga tgccggttca caggttcact tcaaggctat
     5581 gagaaagctc gctgccgaag ctcctgccga agtattcggt aaggaagtta gaaagctcta
     5641 cagctggtct gacgaagata agctcatcaa caactaatgc gagtgtctcg cacacagttc
     5701 gtgaagacag tttgatgtat tcaaacttct gtcacccgag cattacatag tacgaattta
     5761 gggtagcttg attttcaagc tacccttttt gcgagcacct cgcccgcagt tcgtgaagtt
     5821 agtttgatat attcaaattt ctgtcacccg aacattacat agtacgaatt aacggttcag
     5881 tcaatttggc tgaaccgttt ttttgttgtg caataaaagg gttcagcttt ttacggctga
     5941 gcccttttgc agttaaaact tattaatttt taaataatca atacttctca taggagaaag
     6001 aattatatgc gtcaagcaaa gactgcttat tctcagcggt agttttctca ccccatacgc
     6061 tggcatcacc ataacctgtc gcaataaatt cggtaaacat atgtgcattc acgcaattat
     6121 taaactgttt aaggttaatt tcgttatatt ttgcccgtga aatatttttg tcattaccgt
     6181 caaaatatct ataataaata ttatcatttg attcttcgcc tacgcctctt gccgaataca
     6241 tatttgcaaa aagattctct ccgtcgtatg tgattattga attacccgac caatagtaac
     6301 cttcatctac atttaaatat atatccaggt cgtgaacctc atactttttg gcagttttat
     6361 tatagtatat cgaaaaaccg tcgttaacat ttcccactct ttttaactta ccgtcttcaa
     6421 atttgtaaac aacggaatgg aaactatact cattggaatc agccttttgt gcaacaagtt
     6481 ccggaactcc gtcaaaatcg aaatccaaaa acataacacc tgacaaattg tgatcacttc
     6541 ccaagcttgg catccattca ctctgatgat tcatcatata attgatataa gcgtctcttg
     6601 ttttatcgga tgtcttatat ctgtatgtta caccggttgg gttaaacatc gtagtaaact
     6661 ttttaccgtc ttttgaaaca cctcttaccg tataagtgtt actgccggac tttgcaccct
     6721 tgtgaacata atagttgtca taagtttctg ctatcttctt ccaagaaccg ttttctttaa
     6781 tataaacacg gaactttggc gcatctcccg tccaatgcat ttcaacaccg ttgtttactg
     6841 caccaatact gtaaatttcg ggacaatcct gatgatcgcc aatgggcgta ccctttgaat
     6901 cgtagccgct tgtaaaactc ttagcatctt tgctgataca acgaaccgtg taataaatat
     6961 catcaacgct taaatcaaat tcctttgaaa caacattcat atcaagcata gtcgtgcctg
     7021 ttgtatcggc aagctttgtc caaccgtttc tgtccttgta gtacacacga tacttctctg
     7081 cacctgctac cttgttccat gtcagcttta cgccgtcata tgtaacctca agttttgaaa
     7141 ttttcggtgt ggcaacatac tttaccgact tgcctgtcgg gttataaccg cttgtgaatt
     7201 tctttgcgtc tgatgtaata catcttacag tataagtgta atttctgccg gatgaaacat
     7261 ccttgtcgat atatgaggtt gaagttgtat caaccatttt tgtccagcct ttactgcctt
     7321 tgtagtaaac tctgtattta gttgcaccgc ttactttgcc ccaagagatt ttcacaccgc
     7381 cgtttacatt ttcaagcttt gaaatttcgg gggcggcaat atattttaca gttgtcccct
     7441 ttgaatcata accgcttgta aagctctttc cgtcagcaga aatacatctt acggtatagg
     7501 tgtaattcct gcccgatgaa acatccttgt cgatatatga tgttgaagtt gtatcgacca
     7561 ttcgtgtcca acctttacgg cctttgtagt aaactctgta tttagccgca ccattcactt
     7621 tgttccatgt aagctttaca ccgccgtaaa cgctttcggc ttttgaaatt ttcggagttg
     7681 ccaagcttgc ccttgcaacc tgtgcatact gcacgggtgc gttaagcggt tcaaccgcat
     7741 ttgcagaaac tgccgaaacc gcaaccgcag acatcgacat taccgccgcc atggctatag
     7801 gtaaaaactt tttcatatct atccctcgct tcaattagta tttatcatat gagaatgaat
     7861 catatgaatc aagcaatgcc tgctttctct gagaatatga catattgttc caatttgtgt
     7921 ccgtagctgt ttgataaata aactggctgt acatatgaac atttacaaga tttgtaaatt
     7981 tacttctcat aatatcatta taagtagatt ttgagatttt tttataattt cctgctccac
     8041 tataatatcc acctatacca ttataataag tatattcata atttccactt gcagtattca
     8101 taggatacgc aacataaaac ataccaaaat aatcagttgt tatagtagaa ccattatatt
     8161 tgagttgaaa ctgaccgtat gaatgatcat tcatagtacc tgcggctaaa attgatgtgc
     8221 caaatatttc atatttttta ctacttttgt tataatacat tctcaatcta ttttgtatat
     8281 agttttcatt gtactgagcc tgaacaagtt taccgtttct aaatgaataa accttagcat
     8341 caaaattaca catagtacca cctgtttcct gaacaaccag ctcaggaaca ttgtcaaaat
     8401 caagatcaat aaattgaaac cctgactgtg ccatcatacc aacaccataa tcgtggggta
     8461 gccatttgtt ttgattattc ataagataat taacaaattc atctcttgtc ttattagtag
     8521 ttttatactt taatgtcaca cctgacggat tgtaggaaga tgtaaacttt ttaccgttct
     8581 ttgatacacc tcttaccgta tatgtataga tttttcctgc cttaacattt ttatctgtgt
     8641 aatattggtt ataagtttca gcaagtttct tccaagagcc gttttctttc ctgtaaatac
     8701 ggtattttga gttttcaggc aaagcataat taaactcaag ttttatacca ccactaacag
     8761 ttgatatatt ccttacatcc ggaattgatt gcttataacc tgtcaatgct tttccttttg
     8821 aatcatatcc acttttgtaa ctcttgccgt ctttacttat acaacgaact gtatatatcg
     8881 tattagcaac accttgagaa atattatatt ctgcaggata taatccctca tcaacaacac
     8941 ttgtaccagt tgtgtcaaca agtctattcc agcctgttct gtctttgtaa tacacacgat
     9001 atttttcagc acccgttact ttattccaag taatttttgt gccatcatac acactttcaa
     9061 ctttagaaat tttgggagca gcaacatatt ttacactttt gccttttgaa tcataaccgc
     9121 ttgtgaactt tttgccgtct ttgcttatac atcttacagt ataggtgtaa ttcctgcccg
     9181 atgaaacatt cttgtcgata tatgaggttg aagttgtatc aaccattcgt gtccaacctt
     9241 tactaccctt gtagtaaact ctgtacttag ccgcaccgtt cactttgttc catgtaagct
     9301 ttacaccgcc gtaaacgctt tcagcctttg aaattttcgg agttgccaag cttgcccttg
     9361 caacctgtac atactgcacg ggtgtgttta gcggttcaac cgcatttgca gaaactgccg
     9421 aaaccgcaac cgcagacatc gacattaccg ccgccatagc tataggtaaa aactttttca
     9481 tatctatccc tcgctttaat tagtatttat cgtacgagaa tgaatcgtat gaatcaagca
     9541 atgcttgctt tctctgagaa taagacatct tgttccaaca tttatctgta ttaacacgca
     9601 aaataaactg actgcgttta tgtgcattta cacggtttgc aaatctgctt ctcaatatat
     9661 cattgtaatt tgatttagaa atctctttaa tattatccga agaagcataa tagcctttca
     9721 atcctttata gtaagtataa tccatctgcg aagtatgttc tccaaatttg ccttccatat
     9781 aataagcagc aaagtaatct gtagttactt ttataccatc atatttaaat tggaattgac
     9841 tttgtcctaa atcatgaaaa agccctgaag atgaacaggc agtaccaaac aattcgtatt
     9901 ttttactgct cttattgtaa taaattctta atctattctg aataacattt tcatcatact
     9961 gtgcttttac aagcttgccg tttttaaaag aataaactct tgcgtcataa tttctcattg
    10021 ttccaccaga ttcctgaaca atgagttccg gaacgccgtc aaaattaaga tcagtaaatt
    10081 caaagccgga atgtgcaaca actaatcctg aatcataatt gctcggcaac cattcattct
    10141 gatgattcat aagataatta acaaaatcat ctcttgtttt attagttgtc ttatacttta
    10201 atgtcacacc tgacggatta aaagaacttg taaacttttt gccgtccttt gacacacatc
    10261 taactgtata tgtatagctt tttcctgcct taacattttt atctgtgtaa tattggttat
    10321 aagtttcagc aagtttcttc caagagccgt tttctttcct gtaaatacgg tattttgaat
    10381 ttgaagtcaa agcattatta aaatcaagtt ttataccgtt gctgacagtt gatatgtttt
    10441 gtatgttagg atgatattgc ccatcgactg cagttttacc ttttgaatca tatccgctta
    10501 caaatttttt cccatcacca cttatgcaac gaacagtata tgatacccta cggttttcaa
    10561 aagtactacc ttcactaact aataaaccat catcaaccac acttgtgcca gttgtatcta
    10621 caagtctatt ccagcctgtt ctgtctttat aatacacacg atatttttca gcacctgcga
    10681 ccttgttcca tgtcagcttt acgccgtcat atgtaacctc aagttttgaa attttcggtg
    10741 tggcaacata ctttaccgac ttgcctgtcg ggttataacc gcttgtaaat ttctttgcgt
    10801 ctgatgtaat acatcttaca gtatatgtgt aatttctgcc ggatgaaaca tccttgtcga
    10861 tatatgaggt tgaagttgta tcaaccattc gtgtccagcc tttacggccc ttgtagtaaa
    10921 ctctgtactt agccgcaccg ttcactttgt tccatgtaag ctttacaccg ccgtaaacgc
    10981 tttcggcttt tgaaattttc ggagttgcca agcttgccct tgcaacctgt gcatactgca
    11041 cgggtgtgtt tagcggttca accgcatttg cagaaactgc cgaaaccgca accgcagaca
    11101 tcgacattac cgccgccata gctataggta aaaacttttt catatctatc cctc
//
