LOCUS       c00035_gnlPro..        13827 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HFJIEPDP_35.
ACCESSION   c00035_gnlPro..
VERSION     c00035_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:43:44
            Original ID  :: gnl|Prokka|HFJIEPDP_35
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 5725
            Orig. end    :: 19552
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13827
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[15725:18953]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13827
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13827
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             52..672
                     /locus_tag="ctg35_8"
                     /transl_table=11
                     /translation="LLWLYILLGIVLFIALVMFIPITLRASYKEEFWCAVYIGFVKLQL
                     VPAKPKKEKKKKKAKKQTQKTEQPKKATEKKPSLIKKYGIEWLLNLIKKVAELAVSALQ
                     DFFSHILVKKLSLSISVAGDDAADTAIKYGKYCAVVYPAVGTIVRVVKCKGYGVDINPN
                     FSEKAETEINFDFAARIFAFRLIGLAVKHGIKGIKLLAEVKND"
     CDS             703..1122
                     /locus_tag="ctg35_9"
                     /transl_table=11
                     /translation="MEHPIGSLMDTTMEKIKEMIDVNTIIGEPITSPDGTLIIPVSKVS
                     YGFAAGGSDLPTKKENKDCFGGGSGAGVTIQPVAFLTVYQGDVRLVSVDREECTADKLV
                     NMIPDVLKKVKGVFKKDKSESADDFSEITQDDIDG"
     CDS             1174..2298
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_10"
                     /sec_met_domain="Peptidase_S11 (E-value: 1.4e-57, bitscore:
                     185.3, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKISLAVCFVMPFVLMGAKTAEDTPPTTFAQAFVLYCPDNNTV
                     ICSKNADEKMKPASTTKIMTSLITLEEAASCNSEVTFKQEMVAEGSSMYLKVGEKVRLS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMMNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENNDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLSLYPYCTGGK
                     TGYTTVAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKDSVTVTGEKNNTIVLKREDCDKIKKKIFIDSFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGEKIKSDKKSVSIFSAIGNLFS"
     CDS             2342..3091
                     /locus_tag="ctg35_11"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVRVIHKEQGRVILEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             3321..4634
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Vparvula"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_12"
                     /sec_met_domain="CT_Vparvula (E-value: 6.7e-77, bitscore:
                     249.5, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIEKINQAKAEIGATSAYKTITAFFDADSFCEIDAFAKSGEGFA
                     EVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVGFYDSVGG
                     RLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIMSKDAQLS
                     LSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSFEEAPAED
                     GCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGNELGCKSANKVAKF
                     VRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSGYVALAGT
                     GANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLSAYNAAQN
                     GYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             4673..5038
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_13"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.7e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSLAPAAAAPAPAAAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             5069..6472
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg35_14"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.1e-55, bitscore:
                     178.9, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPEFQKKIIGDKKI
                     IKGRPADQLEPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             6667..7674
                     /locus_tag="ctg35_15"
                     /transl_table=11
                     /translation="MKKLLTALIAFVMCFSVVTTAFAATPDEASDSDLISDIKQAMLDT
                     YYGDEKPEYLNVEILLDDEDEVYFSFSDSFATSANRVYTEAGNYIVSYLENCPVALYKN
                     NRVYMIPDAYNSGVIDDDTLEGLTYCGHMDIVPKSDDSALVIEIKNKVIEECFDGKSPE
                     TLRIDIVGRTSDGGVYFKHSVGGGIDVMVEETIGDYTYHYNHNDDVMLYKNGNVYSIKE
                     AYESGVIDDSILEELSKMNFGLESNKPNTTVPTEPTTTVATVDEPVTVPDTTSATSATK
                     PVSTSDTATKDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNYFK"
     CDS             7871..9709
                     /locus_tag="ctg35_16"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVAVSAVSANAAEPLNTPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGTTVKYIAAPEISKLESVNGGVKISWGKVSGATKYRV
                     YYKGSKGWTRMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVKYVA
                     TPKISKLEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSKEFD
                     LSIDDIYYTVRCISKDAKSFTSGYDSKGTPIGNHQDCPEIYSIGAVNNGVEMHWTGDAP
                     KFRVYIKENGSWKRIAETYDNYYVHKGAKSGSNTYTVRGVSKDGKKFTTMFNPTGVTYR
                     YKTSDKTRDAYINYMMNHQSEWMPSLGSNHNLSGVMFLDFDFDGVPELVAQKADSNEYS
                     FHSVVYKFEDGKLKRVGNVNDGFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSIITY
                     DGENLFANMYSARGVGEESNNNIYYNYFDGNDKNISRAKYNEINLKQFNNCVNAHMFTQ
                     FIATGYGDNSVWGENTTAENKQSLLDAYNSFSYEKY"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_17"
                     /sec_met_domain="IlvN (E-value: 1.2e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 8.6e-61, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_18"
                     /sec_met_domain="ALS_ss_C (E-value: 2.7e-30, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg35_19"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.3e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(13425..13826)
                     /locus_tag="ctg35_20"
                     /transl_table=11
                     /translation="FDFKNNYLCYQNFSITRCIGYIDSDKLKKSDISEDVDDTFSIVSA
                     SEDDSDTNLLYKRAESSSENNYIYLFDTTNKTMKETKFNIEEKWYTIGGISRIGKDNLM
                     IMMSPDNADKKSDLNPRIYFTKLSDLKFQ"
ORIGIN
        1 tgcttgccga tcagcctgtt gacaggcagt aaaatttagg gggaattccc tttgctttgg
       61 ctatatatcc tactcggaat tgtgctgttt attgcgcttg tgatgtttat tccgattact
      121 ttgcgtgcat catataaaga ggagttttgg tgcgccgtgt atatcggatt tgtaaagctt
      181 cagcttgtgc cggcaaaacc caaaaaggaa aagaagaaga aaaaagcaaa aaaacaaact
      241 cagaaaaccg aacaacctaa aaaagcgaca gaaaaaaagc cgagtcttat aaaaaaatac
      301 ggtattgagt ggcttttgaa cctgataaaa aaagttgcag agcttgcagt atctgcattg
      361 caggattttt tcagccacat actggttaaa aaattgtcgc tgagtatcag cgttgcaggt
      421 gacgatgcgg ctgacacggc tataaaatac ggcaaatact gtgccgttgt ttatccggca
      481 gtaggcacaa ttgtccgtgt tgtaaaatgc aaaggctacg gagttgacat aaatccgaat
      541 ttttcggaaa aagcagaaac agaaattaac tttgactttg ccgcaagaat tttcgcattc
      601 cgacttatcg gtcttgccgt taagcacgga atcaagggaa ttaaacttct tgcagaagtt
      661 aaaaatgatt gatataaata ttgttgaaaa aggagaatgg ctatggaaca tcctatcggc
      721 agtttaatgg ataccacaat ggaaaaaatc aaggaaatga ttgatgtcaa tactattatc
      781 ggcgagccta taacttcgcc tgacggcaca ctcatcattc ctgtttcaaa ggtaagctac
      841 ggctttgcgg caggcggttc ggatctgcct accaaaaagg aaaacaaaga ctgctttggc
      901 ggcggcagcg gtgcaggtgt gacaattcag cctgttgcat ttcttaccgt ttatcagggc
      961 gatgtaaggc ttgtttccgt tgacagggaa gaatgtacag ccgacaagct cgttaatatg
     1021 attcccgatg ttctcaaaaa agtaaaggga gttttcaaaa aggataagag cgaatccgca
     1081 gacgattttt ccgaaatcac acaggacgat attgacggct gattcgtaat attgcaacac
     1141 ccctcggcat agatttatgc agggggtgtc cttatgaaaa aaaaaatctc gcttgcggtg
     1201 tgctttgtta tgccgtttgt gcttatgggc gcaaaaactg cggaggatac tcctcccaca
     1261 acttttgcac aggcatttgt tctttattgt cccgataaca acacggttat ctgttccaag
     1321 aatgcagatg aaaagatgaa gcctgcgagc accacaaaga ttatgacatc tctcataacg
     1381 cttgaggagg cggcatcctg taacagcgaa gtaaccttca aacaggaaat ggttgccgag
     1441 ggcagttcga tgtatcttaa agtcggtgaa aaagtccgac tttcggatct tgcgtcagga
     1501 atgatgatgg cgtcgggtaa tgatgcggcg aatgcggcgg catatacgat ttcgggcagt
     1561 cccgaaaagt tttcacaacg aatgaatgaa aaggcaaagc aaatcggtat gatgaatacc
     1621 aattttgtga cgccgagcgg acttgacgat gacaaccatt actcaagtgc aaaggatatg
     1681 gctctgctta tgtcatatgc acttgaaaat aacgattttg caaatcttac ggctaagaag
     1741 agcgtgaccg ttgaatttct tgaaccgaaa tcaaagaaaa ccgcatatgc aaatcataac
     1801 aggcttttgt cgctttatcc atactgtaca ggcggaaaaa caggctatac aacggtggca
     1861 gggcggtgcc ttgtttcctc tgcaaaaaaa gacggtgtaa cgcttgtgtg cgtcactctg
     1921 aatgaccgca acgattggaa tgaccatatt tctctttatg attacgcttt tgaaaagtat
     1981 aggggagttg actgcaagga cgctgacttt tgtgccgata ttccgtgcgt gggcggtgat
     2041 aaggacagcg taacggttac aggtgagaag aacaacacaa tcgttttaaa gcgtgaggac
     2101 tgcgataaaa tcaagaaaaa aatcttcata gacagctttt tgtatgctcc gattgaaaag
     2161 aacgaatcgg tcggcagaat tgaatacaca ctcggcggaa agctgcttta taaatgcaac
     2221 attgttgcag gcgaaaagat taaatcggat aaaaagagtg tgtcaatatt ttcggcaata
     2281 ggaaatctgt tttcgtgaca gtttaaatat acagaaaatt ttaataaaaa ggaatttaca
     2341 tatggctaaa attgaaccta taagacttca gaaattcata gcgcaatgcg gtattgcgtc
     2401 aaggcgaaag gccgaggagc ttattctcgg cggtcatgtc aaggtgaacg gcaaaaccgc
     2461 aattctcggc gataaggttc ttcctacaga caaggtgttt gtaagaggca agaggattgt
     2521 tgtgccgaag ggcggtaatt accgatatat tatgctcaac aagccccgtg gattcattac
     2581 cacaatgaat gatgagcgtg gcagaaagtg tgttgcacag cttgttgaga atgtcggcga
     2641 gcgagtttat ccgatcggca gacttgacaa agacagcgag ggtatgcttg tttttacaaa
     2701 tgacggtgac tttgcaaaca aggttatgca tccgaaaaac aatgtttaca agatttacag
     2761 agtaaccgtt cgaccgtcaa ttgacgagga tcagcttgta aagcttgaaa caggcgttga
     2821 gcttgacggc aggaaaaccg ctcctgcata tgtccgtgta attcacaagg agcagggcag
     2881 agtaattctt gaaatgattc ttcacgaggg taagaaccgt gaaatcagaa gaatgtgcga
     2941 ggctgtcggg cttgaggttg caagactcaa acgcacccag atcggcggag taaaaatggg
     3001 tatgctcaaa cagggcgact ggagagattt gaccgaacaa gaggttaaaa aactgcttgc
     3061 aaacccgttt ttaaacggca aacagcttta attttccgtt tttgaaaaat acttccgaaa
     3121 cggtcaataa aactattcgt taattcgaca ataaatttac ggttttagtg taataactat
     3181 taaatgtgtt caaaattgaa atagtacagc gtgtttttct tgtacttttg aagattatag
     3241 agtataatgt atgtgtagaa aattagtatg cacgctcagt tttcgtgcat attcaataca
     3301 tggtattgga ggattttaag atgagtattg aaaagatcaa tcaggcaaag gctgaaattg
     3361 gcgcaacttc cgcttataag acaattacgg cgttttttga tgcagacagc ttttgtgaaa
     3421 ttgatgcctt tgcaaaatcc ggtgaaggtt ttgccgaggt tgttgcaggc tttggaacag
     3481 tagaaggtat gcctgtttat gcgtttgcac agaacagcga catttgcggc ggtgctatga
     3541 gtaaggcaca ggctgccaag cttaaaaagc tgtatggtct tgcactcaag acaggcgctc
     3601 ctgttgtagg cttctatgac agcgttggcg gcagacttaa tcagggtaca gagcttctcg
     3661 caggttgcgg tgatgttctc aatgcggctg cgtcactttc cggtgttgta ccgcagatct
     3721 cggttgttct cggcacttgc ctcggaacaa acgctcttaa cgccgcaagc gcagacatcg
     3781 ttatcatgag caaagacgca cagctttcac tttcggtaac aggcaagcat tccgatgccg
     3841 cttacaatgc tgaaaacggt attgcctcaa tcgtttgtga cgacgcagac aaggcaatca
     3901 aggctgcaaa ggaacttatc ctttatcttc cgtcaaataa cctcacaatg gctcctcagt
     3961 catttgaaga agctccggca gaggacggtt gcggttgtgt agtcagcaga acagttgacg
     4021 gcaacagcat tgtaaagctc ttcaatgatt acggcaagga agcaaatgtt cgttttgcaa
     4081 gactcggcgg tcaggttgta ggtattgttg ttacaaaggg caatgagctt ggttgcaagt
     4141 ctgcaaacaa ggtagcaaag tttgttcgtt tctgcgacgc tttctcactc cctgttgtaa
     4201 cattcgtaaa ctgcccgggc tttgagtcaa tcaagtcggc aacaaaggca tcagccgctt
     4261 atgctgaggc aacaacagtc aagatttctg ttgttacagg caaggcaatc ggttcaggct
     4321 atgttgctct tgcaggcaca ggcgctaatg cagatgttgt ttacgcactt cccgatgcgg
     4381 ttatttcacc tgttaatgtt gaggctgccg cattcattat ggctcccgaa gttatgaatg
     4441 ttgccacaga taagcaggct gaggttgctc agaagtttgc tgacgagaat ctttctgctt
     4501 acaatgccgc tcagaacggc tatgttgacg gtattgttga agaagctcag ctccgtcaga
     4561 ctcttatttc tgctcttgat atgctctcgg gcaagcgtgt ttcaacactt tcaaagaagc
     4621 attcaactat ctgataaatg attacttgtt aaaataaaag gggatactaa aaatgaagaa
     4681 tttaagaatt acagttaacg gcacagcata tgatgttcag gttgaagaac tcggtggctc
     4741 tttagctccc gcagcagccg ctcctgctcc ggcagccgct cccgctcctg cagcaaagcc
     4801 ggcagctccc gcaggcgctc agggttctgt tgttgtaaag gctcctatgc ccggtacagt
     4861 tgttaatgtt gttgtttcgg caggacaggc tgttaaggcc ggagatgacc tcgtattcat
     4921 cgaggctatg aagatggaaa ctcccgttaa ggctccgcag gatggcacag ttgcaacagt
     4981 tgatgttgca aagggtgagt ctgttgactc aggtaaggtt ctcgtaacac ttaactaatc
     5041 aataattcgg agaaagggat gctgtaaaat ggcaaaaaaa atcagagtta ccgaaactgc
     5101 tctgcgtgac gctcatcagt cactcattgc aacaagaatg acaacagagg aaatgctccc
     5161 tgttcttgac aaactcgata aaatcggtta ttactcactc gaatgctggg gcggtgcaac
     5221 atatgactca tgcctcagat tcttaaacga agatccgtgg gacagactcc gcacaatcag
     5281 agagcattgc cctaacacaa agctccagat gcttttcaga ggacagaata tgctcggtta
     5341 tcgtcactat gccgatgact gcgttgagta ccttgttcag cgttcaatcg caaacggtat
     5401 tgacattatc cgtatttttg atgctcttaa tgacatcaag aatcttaaaa cagctatcaa
     5461 ggccgctaac aaagaaggcg gtcatgcaca ggttgctatc agctacacaa caggtcctgt
     5521 attcacagat gaatactatg ttgagtatgc taagagaatt gcagacgcag gtgcagattc
     5581 aatctgtatc aaggatatgg ctgctcttct tactccgaca agaaccgaaa gccttgtaaa
     5641 ggctatcaaa gccgctgttc cggagcttcc gcttcagctc cacacccact acacatcagg
     5701 tcttgcatca atgtgtcttt taaagggtgt tgaggcaggt gccgacggca ttgacacagc
     5761 aatcagccca ctcgctctcg gtacatcaca cgcacctaca gagtcaatgg ttgccgctct
     5821 ttcaggcaca gagttcgaca caggtcttga ccttaaacag ttctctgaca tccgtgctta
     5881 cttcatgact cttcgtgaga agtacatcaa gtcaggactt cttgatccta agatgctcgc
     5941 aacagacgct aacgctctta tctatcaggt tcccggcggt atgctttcca accttctttc
     6001 acagctcaag caggccggta aagaagacaa gcttgacgaa gttcttgcag aagtaccccg
     6061 tgttcgtaag gattcaggtt atcctccgct tgttactccg acatcacaga ttgtcggcac
     6121 acaggctgta ttcaatgtaa tcacaggcaa gcgctactca atgtgcacaa acgagttcaa
     6181 gggacttgtt gccggtgagt acggtacaac tccaatgccg attgatcctg agtttcagaa
     6241 gaagattatc ggtgacaaga agattatcaa aggccgtcct gcagatcagc ttgagcctga
     6301 gcttgataag ctccgtggcg agattgagca gtggattgaa cagcctgagg atgttctttc
     6361 ttatgcacag ttcccgaagg ttgccctcga cttctttgaa aagagaagaa atgccaaggt
     6421 tggcatcaac ggcgacaagc ttgacaagaa aaatatggtt cacccagttt gatttgacaa
     6481 ctaaaattaa catttatgcc actttcgcta tgaaagtggc attttcattt gagcagaatt
     6541 atttttgcta aatttttagc aactatattg cattacatat attttagcgg tataatgaag
     6601 taaattgaat atctgttgcg tataccatta ttacagatag aataaataaa agatgaggaa
     6661 ataaaaatga aaaaactttt aactgcattg atagcatttg taatgtgctt ttcggttgta
     6721 acaacagctt ttgcggctac accggatgaa gcttctgatt cagacttgat ttcagatatt
     6781 aaacaggcta tgttagatac atattatggc gatgaaaagc ctgaatattt gaatgtcgaa
     6841 attcttttgg acgatgaaga cgaggtttat ttcagttttt ctgacagctt tgctacttct
     6901 gcaaacagag tttacaccga ggcaggcaat tacatagttt cttacctcga aaattgtcct
     6961 gtggcactgt acaaaaacaa cagggtttat atgatccccg atgcttataa ttcaggcgtt
     7021 attgatgacg atacacttga gggtttgacc tattgcggac atatggatat agttccgaaa
     7081 agcgatgatt cagcacttgt tatcgaaata aaaaacaaag ttattgaaga gtgttttgac
     7141 ggcaaatcac ctgaaacttt gagaattgat attgttggca gaacaagtga cggcggagta
     7201 tattttaaac acagcgtagg cggcggtatt gatgtaatgg ttgaagaaac aattggtgac
     7261 tatacttatc attacaacca taacgatgat gttatgcttt ataagaatgg caatgtttac
     7321 tcaattaaag aggcttatga aagcggagtt attgatgata gtattcttga agaattgtca
     7381 aaaatgaatt ttggtttgga atctaataaa ccgaatacaa ctgttcctac tgagcctaca
     7441 actacggttg caacagttga cgaacctgta acagtacccg atacaacttc tgcaacttcg
     7501 gcaactaagc ctgtttcaac aagcgacaca gcaacaaagg acacaccgaa caattcacag
     7561 aataacagcg gtgctgtaca gacaggacag aacagcgttg ctgtaattct tcttgttgca
     7621 atgcttgcag gttgtgcagt aatttttgca aaacgcagaa attattttaa ataattcaaa
     7681 acatcaacag aatatataaa ataaaccgtt ctcgcttttg tgaacggttt atttatttta
     7741 gcttaaaaat ttgtgatagt ttatcaagat gtattgcttt ttatatcatt taatgttaca
     7801 attaacttgc ataaaaattt agcaaaagtt tttaataatg cgtagaatat ttacaaagcg
     7861 agggatagat atgaaaaagt ttttacctat agctatggcg gcggtaatgt cgatgtctgc
     7921 ggttgcggtt tcggcagttt ctgcaaatgc ggctgaaccg cttaacacac ccgtgcagta
     7981 tgcacaggtt gcaagggcaa gcttggcaac tccgaaaatt tcaaaagccg aaagcgttta
     8041 cggcggtgta aagcttacat ggaacaaagt gaacggtgcg gctaaataca gagtttacta
     8101 caagggccgt aaaggttgga cacgaatggt cgatacaact tcaacatcat atatcgacaa
     8161 ggacgtttca tcgggcagga attacaccta tactgtaaga tgtatttctg ctgacggaaa
     8221 gagctttaca agcggttatg attcaaaggg gacaactgta aaatatattg ccgcccccga
     8281 aatttcaaag cttgaaagcg taaacggcgg tgtaaaaatc tcttggggca aagtaagcgg
     8341 tgcaactaaa tacagagttt actacaaggg cagtaaaggc tggacacgaa tggtcgatac
     8401 aacttcaacc tcatatatcg acaaggatgt ttcatcgggc agaaattaca catatactgt
     8461 aagatgtatt acatcagacg caaagaaatt tacaagcggt tataacccga caggcaagtc
     8521 ggtaaagtat gttgccacac cgaaaatttc aaaacttgag gttacatatg acggtgtaaa
     8581 gctgacatgg aacaaggtcg caggtgctga aaaatatcgt gtgtactaca aggacagaaa
     8641 tggttggaca aagcttgccg atacaacagg cacgactatg cttgatatga atgttgtttc
     8701 aaaggaattt gatttaagca ttgatgatat ttattacacg gttcgttgta tcagcaagga
     8761 tgctaagagt tttacaagcg gctacgattc aaagggtacg cccattggca atcaccagga
     8821 ttgtcccgaa atttacagca ttggtgcagt aaacaacggt gttgaaatgc attggacggg
     8881 agatgcgcca aagttccgtg tttatattaa agaaaacggt tcttggaaga ggatagcaga
     8941 aacttatgac aactattatg ttcacaaggg tgcaaagtcc ggcagtaaca cttatacggt
     9001 aagaggtgtt tcaaaagacg gtaaaaagtt tactacgatg tttaacccaa ccggtgtaac
     9061 atacagatat aagacatccg ataaaacaag ggacgcttat atcaattata tgatgaatca
     9121 tcagagtgaa tggatgccaa gcttgggaag taatcacaat ttgtcaggtg ttatgttttt
     9181 ggatttcgac tttgacggag ttccggaact tgttgcacaa aaggctgatt ccaatgagta
     9241 tagtttccat tccgttgttt acaaatttga agacggtaag ttaaaaagag tgggaaatgt
     9301 taacgacggt tttgcgatat actataataa aactgccaaa aagtatgagg ttcacgacct
     9361 aaagatatct ttaaatgtag atgacggtta ctattggtcg ggtaattcaa taatcacata
     9421 cgacggagag aatctttttg caaatatgta ttcggcaaga ggtgtaggcg aagaatcaaa
     9481 taataatatt tattataatt attttgacgg taatgacaaa aatatttcac gggcaaaata
     9541 taacgaaatt aaccttaaac agtttaataa ttgcgtgaat gcacatatgt ttacccaatt
     9601 tattgcgaca ggttatggtg ataacagcgt atggggtgag aacactaccg ctgagaataa
     9661 gcagtctttg cttgacgcat ataattcttt ctcctatgag aagtattgat tatttaaaaa
     9721 ttaataagtt ttaactgcaa aagggttcag ccgtaaaaag ctgacccctt ttattgcata
     9781 acaaaaaacg gttcagccaa attgactgaa ccgttaatct gtactatgtt aagcttggaa
     9841 acaagtagtt gtaaattatc acaaactacc tacacgaact gcgggcgagg tactcgcaaa
     9901 aagggtagct tgaaaatcaa gctaccctaa attcgtacta tgtaatgctc gggtgacaga
     9961 agtttgaata tatcaaacta acttcacgaa ctaaaaaaca ttagttgttg atgagcttat
    10021 cttcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cggcagcgat ctttctcata gccttgaagt gaacctgtga accggcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcgt ttcttgggtc gtaaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcgcaaa caccgccgca aagaacagcc tgttcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacgccggct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagca tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgacccg
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagcg aacataagca tattgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttgta aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgccgat gtatatacct taaagccctg tgcctcagcc tttgcccagc
    10861 tcttgctgcc tttgtaaaga ccgatgatta catcgcaacc tgaatccttg aggttgagag
    10921 cgtgtgcatg accctggctg ccgtaaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttaca atctgactga tagtagattg gtgctgtcat gttttttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta aaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt caatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gatgcggctt gcacattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat ttttgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcacagtg aaccttgatt aaaacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacctt aataacggga atgagcttgt
    11401 tgagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cgggtcctga gtaacaccta ctgcgagtga gtcgatgtta aaacctcggc
    11521 gagagaaaag tcccgaaatt tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttcc gaatcaacaa tacccttgat gatgttttcg gcttccttgt
    11701 ttgaatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgca gagtgtctgc cgccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tagtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacat
    11941 cacggtctgg tcttgcaaac tttgcaccga ttgcagcggg aattgagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacgtcg gcaacaagaa ttgcctttga gcggaacatt gcactgagat
    12121 gaccgacaag tgttctcggc tcaacaaagc cgtcaaaaac gggaggctca cggtaaaggt
    12181 cttttttcca gttctttacg gtttcgctcc acattgttgt aaccttgtaa tcgccgatgc
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tctgttttaa
    12301 cattcttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agccgcaaca gctctgtcac cgagtcttgc accgcatacg attacaaggt
    12421 cggcttcgtg aagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaacttagt acgccgccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttagtgttc ggcttgtaac cgatgatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc cgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggtcgca atacctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgaatc gtaaacttta tcgtaaaatg
    13141 ggcaaatagc cgcaccggga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct ttttactgtg
    13261 agcaaaaggt gttttgtaac attaaatata cctttttact ttaccgctaa ttatacaata
    13321 aataccttaa aaagtaaaga gcagtattgc ccataaatta aattttttgc aggattttga
    13381 cagataattt gcaaaatgaa ttttaattgt tttttactcc ctgcttactg aaattttaag
    13441 tcgcttagtt ttgtaaagta tattcttgga ttaaggtcac tttttttgtc tgcattatca
    13501 ggggacatca ttatcatcaa attatctttt cctatccgtg atataccgcc tatagtgtac
    13561 catttttctt caatattaaa ttttgtttct ttcattgttt tgttggtcgt atcaaaaaga
    13621 tatatgtagt tattttctga acttgattcc gccctcttat acaataaatt tgtatcactg
    13681 tcatcttcag atgcggatac tattgaaaaa gtatcatcta catcttctga tatgtcggat
    13741 tttttcagct tatcgctgtc tatatatcct atacatcttg ttatgctgaa attttgatag
    13801 catagataat tgtttttaaa atcaaaa
//
