LOCUS       c00292_gnlPro..        12976 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JBBMAOED_292.
ACCESSION   c00292_gnlPro..
VERSION     c00292_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:12:57
            Original ID  :: gnl|Prokka|JBBMAOED_292
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12976
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12976
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4279:12663]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4280..12663
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..12976
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12976
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             380..1378
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.1; E-value: 9.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg292_1"
                     /sec_met_domain="SBP_bac_1 (E-value: 2e-18, bitscore: 57.1,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSVTNVSYDPTREMFEQYNK
                     IFEDHWKEKTGDDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             1449..2285
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 82.5; E-value: 1.1e-25)"
                     /gene_kind="transport"
                     /locus_tag="ctg292_2"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.2e-26, bitscore:
                     82.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLVSFYTSFVCAFAAAVINGIMGTVLAWVLVKYDFPGKRLMDGMIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSKLQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             2285..3109
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60.2; E-value: 7.1e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg292_3"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.5e-19, bitscore:
                     60.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVVISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGMKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             3111..4169
                     /locus_tag="ctg292_4"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAKGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVEQVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRDDSVQLI
                     ENEAVRDDFVII"
     CDS             4280..6025
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.4; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg292_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 5.6e-23, bitscore:
                     71.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-08,
                     bitscore: 24.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEALERGGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEK
                     GAGER"
     CDS             6022..6336
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg292_6"
                     /sec_met_domain="Fer4_9 (E-value: 1.7e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.5e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             6367..7485
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg292_7"
                     /sec_met_domain="PAPS_reduct (E-value: 3.9e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             7487..9127
                     /locus_tag="ctg292_8"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMLWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDKHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             9797..10051
                     /locus_tag="ctg292_9"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             10070..10921
                     /locus_tag="ctg292_10"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIVAVCMFSNVHGTEAAGPPAPKTLTVTP
                     TEKSKSTEKLKSTSTSKSKSTPKSKSALTQKPEATPIPASTPTPEQEAETDKQNPADQG
                     TLSKPDHPDTISADKLVFIGDSRTEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQ
                     IEDNTAVIILMGVNDLYHVNDYISYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEI
                     ESFNAAMQANLSGVTYIDVYSHLVSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQRSGI
                     WG"
     CDS             11146..12663
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg292_11"
                     /sec_met_domain="Fer4_7 (E-value: 1.2e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.4e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.5e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTVM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPNCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFRASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             12602..12727
                     /locus_tag="ctg292_12"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKVWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(12835..12975)
                     /locus_tag="ctg292_13"
                     /transl_table=11
                     /translation="RDGNRTYNADAVGAYNILRKYHSVSGVKRELSVTGLKTPEIIKVA
                     V"
ORIGIN
        1 aactgtgctg atcaaacatg caccggcaag tcagatcatt cccacatggc tccagacaac
       61 agcaatgaac tttccgatgg cattcttctg gcagattttt tatgccggac cattcgtaag
      121 atttattttc ggaaagcttt tgccggagaa agaaaaggca gcagcttctg ccgaataaaa
      181 aatatgtaat tttgactgca gcattctgta tttcaggatg ctgctttttt gtgttcttat
      241 ttacacaaca taaattgtac ttattttaat acactattga caaattctgt catttcttgt
      301 aatatcatat aaaacatatc gaataactat gaaaagtaga gaatgcaaaa aactactggt
      361 accttaaagg agatgaaaca tgatcagaaa attatttgcc tttggtcttg cagttgtact
      421 ggcactgatg ccggtacagg cttttggaaa aacggtgtct gtcaccaatg tttcctatga
      481 tcctaccaga gagatgtttg aacagtataa taaaatattt gaagaccact ggaaggagaa
      541 gaccggggat gatgtggaag tgatacagtc ccatggtggt tcagggaaac aggcacttga
      601 ggtagccaat ggtctggatg cagatgtggt aaccctggca ctggaatatg atattgagtc
      661 tattgaaaac gcagggctga tcaaggcagg atggaaagat aaatttgaca atgacagttc
      721 tccttataca tccactatcg tatttctggt gaagaaagga aatcccaggg atatcaaaga
      781 ctgggacgat ctgacgaaaa aaggagtggg agtagtaaca ccaaatccga aaacctccgg
      841 cggtgccaga tggaactaca tggcagcgtg ggcttacgca gataaaaagt atggtggcga
      901 tgaagcgcag atgaaggaat ttattaagaa actttaccgg aatgtggtgg ttcttgactc
      961 aggcgcaaga ggcgcaacga cctctttcgt ggagaacgga caaggagatg tgctggttgc
     1021 gtgggaaaat gaagcttatc tatccatgcg ggattatccg gatgagtatg agattgttac
     1081 tccaagcgta agtattctgg cacagccttc tgtggcggtg gtagatgaag tggtggatta
     1141 cagagataca agagatgtgg caactgagta tttgaattat ctgtattccg acgaagcaca
     1201 ggagatcgca gcagagaatt atttccgccc caccaatgag aaaatcctga agaagcacag
     1261 tgatacgttt gatctgaata taaatctggc aaatatcagt gattatggcg gatgggataa
     1321 agtgcaggag aaacatttca cagatggcgg aattttcgat cagatttatg agagataaag
     1381 gaagacaaga tgaagcaaga gcataagcac agacagaata tatgagacag gagaggtggt
     1441 aattgattat gaaaaaaaga aataaaccgg tgattccagg gtttgggctc tccatgggaa
     1501 ttaccatttc catattgagt ctggtagttc tgatccccct ggcaagcctg gtggtctaca
     1561 cagcgaagct gagttttaaa gattttatcg aaaccatcac aagggccaga gtgttggtat
     1621 ccttttatac cagttttgta tgtgcttttg cagcagcagt aataaatgga attatgggaa
     1681 ctgttcttgc gtgggtgctt gtgaaatatg attttccggg caagagactt atggatggga
     1741 tgatcgaact tccctttgct cttcccacag cggtagcggg tattgcactg acatccctga
     1801 cctcagattc gggaattgtc ggcagctttt ttgcaggatt cggtatcaag atcgcataca
     1861 caagaatagg tattacagtg gctatgatat ttgtaggaat accgttcgtt gtgcgaagtg
     1921 tacagccggt tctggaaaag atggataatt cttacagcga ggcagcagga gtgctgggag
     1981 caaagaaaac aactatcttc tggaaggtca tttttccgga actgaagccc gcgatctttg
     2041 cagggaccgg acttgcgttc ggaagatgtc tgggtgaata tggaagtgtt gtatttatcg
     2101 caggaaataa accctattat acagaaatca caccgctggt tattatgtca aagcttcagg
     2161 aatttgatta ttcaagtgca acggcaatcg cacttgtgat gttggcagtt tcatttttta
     2221 ttctgttcct taacagtatg atacagcaga gaaatgcaag aattttaaga ggaggaaatg
     2281 cctgatggac aacaatgaaa agacttcgga gaaaattaca aaatggctgc ttgtcgtgat
     2341 cagtgttctg tttctggcag tcatgctcct tcttcctctg atcactgtga tcacagaagc
     2401 attgcggagc ggatggaagg tctatgcagc tgcagtgaca gatgagtaca ccatcaaagc
     2461 acttcttctt acagtgaagg caacactctt tgcagttgtt tttaacactg tttttggtgt
     2521 ttttgcagcc tgggcactga cgaagtttca gttcaggggt aaaaagcttc tcactaccct
     2581 gatcgatctt ccggttacta tttcccctgt tattgcaggt ttgatctttc ttctgatttt
     2641 cggacgacag agtcctgttt acttttttct catgaagtta gggatgaaag ttgtattctc
     2701 tgtaccggga atcattattg caactgtatt tgtaaccttt ccttttattt ccagagaact
     2761 gattccggtt ctggaagcag aaggaagcga tgaggaggaa gcggcagccc tgatgggagc
     2821 aggtggatgg accattttct ggaagatcac attccctcat atcaaatggg cattactgta
     2881 tggagttgtg ctctgtacgg caagagcaat gggagagttt ggagcggtat ctgtactttc
     2941 cggacattta agaggaaaga ccaatacact tcctcttcat gtagagattt tgtttaatga
     3001 gtttcagtat gttccggcgt ttgccgtatc ttcgctgctt gtgatcatgg cagttatcat
     3061 tctggtagtc agaagcctga ttgaatataa aggaaagaag gaagcctgat atgtatgtag
     3121 agttaaaaaa tatcaataag acatatggtt cttaccaggc atcaaggaat gtgaatttcg
     3181 gaattgagaa aggtaaactg attggtctgc tgggaccaag cggaagcgga aaaacaacta
     3241 ttcttcgaat gatcgcaggc ctggaaaccc cggacagcgg agaggtcatt attgatggaa
     3301 aagtggtaaa tgatgttccg gccagtcagc gtgggattgg atttgtattt cagaattatg
     3361 cgttgtttcg ctatatgaca gtttatgaca acgttgcatt tggtttgaag gttcagaagg
     3421 ctgataagaa gaaaattgat gccagagtaa gagagctgat caaactggtg gggctggaag
     3481 gactggaaaa aagatatcca agccagttat ccggcggtca gaggcaaagg gtggcatttg
     3541 ccagagccct tgctccaaat ccccaggtgc tgcttctgga tgagcccttt gcagccattg
     3601 atgcaaaaat ccgtcaggaa ctgcgaagct ggttaaaaga gatgatcggg aagctgggaa
     3661 ttaccagtat tttcgttact catgatcaag atgaggccat tgaagtagca gatgagatta
     3721 ttatcactaa tgcaggacgg atcgaacaga aaggaactcc cataggggtt tacagaaatc
     3781 ctgagacagc ttttacagcg tccttcttcg gacagccatc tgtgttgaaa aatgcggatg
     3841 atttccatac ctttgctcag gcaaaaggag cagacaagat cattgtccgc ccggaatttg
     3901 taaaaatctc caaactggat gaagtggaga agttcaaaac ttccgtatcc cggggagtgg
     3961 ttgaacaggt ttctttcagg ggagataatc tggaacttca ggtgagagtc aacaattccg
     4021 tagtaactgc cagaagaagt ctggagaaag cagatatccg ggaaggtgag actgtgaatg
     4081 tattccttta caggattttt gcactgagag atgacagtgt acagctgatc gaaaatgagg
     4141 ctgtaaggga tgactttgta attatctgac aacggtggct gcggcgactg acacaatgaa
     4201 aaaataagaa attcagaggc aagactgatc ggaaaatcaa cttgctggca cactggtatg
     4261 gaggaaaggg taagagagaa tgagaacaga gagaatcagg acagatgtgc tgatcatcgg
     4321 cggcggtacg gcaggatgct ttgcagccta tgtgatcggc aaaaaaagcg gcagaaaagt
     4381 tctgatcgca gagaaagcga atattaagcg aagcggatgt ctggcggcgg gcgtgaatgc
     4441 attgaacgca tatattacag aaggcagagt gccgcaggat tatgtggatt atgccaaaaa
     4501 ggatgcccat ggaatcgtaa gagaagacct tcttcttacc atgtcagaga gactgaatca
     4561 tgtgacaaag gtgatggaag atctggggct ggtcatcctg aaggacgaaa acggaaaata
     4621 tgttgccaga ggaaaccgaa acatcaagat caatggcgaa aatatgaagc caatccttgc
     4681 aaaggcggca gctgaacagg agaatgttac ggttctcaat catgtaaata ttacagatta
     4741 taaaacagaa aacaaaaaag tcacaggcgc agttggattt agcgttaatg aggatatttt
     4801 ctatgacatt gatgcgaaag cagttctttg tgccacaggt ggtgcagcgg gactttacag
     4861 accgaataat ccgggatttt ccagacataa gatgtggtat cctccgttta acacaggtgc
     4921 aggatatgca atgggacttc tttccggtgc agagatgaca acctttgaga tgcgtttcat
     4981 tgcattgaga tgtaaggaca cgattgctcc tacaggaact attgctcagg gcgttggggc
     5041 cagacaggtc aatgcacatg gtgatattta tgaaacaaaa tatggtctga caacttccca
     5101 gcgagtttac ggtacagtca tggagaacag agaaggaaac ggtccatgtt atctcagaac
     5161 ggaaggtatt tccaaagaac aggagcagga cctttacaaa gcttacctga atatggcacc
     5221 gtcccagact ctgaaatgga tggaagccgg aaaaggacca tccgaagaga atgtagagat
     5281 cgagggcaca gagccatata ttgtaggtgg acatacagcc agcggttact gggtagataa
     5341 taacagagct acaactattg aaggtttata tgcagccgga gacgtagcag gaggatgtcc
     5401 gcagaaatat gtaaccggcg cactggcaga aggtgagatc gcagcagagg cgattttgga
     5461 atatctgaat ggcaaagatg atgaccggat cgcagcagaa aataaggaag aggctttaga
     5521 gcgtggcgga gaacaggagc tgtctcaaac tgcaatagct aagaaggcag aatacgaatc
     5581 acatttgaat gcttcccgtt ctttgatgaa tgcagagcag cttgaggaag ccatgcagaa
     5641 gatcatggat cagtacgcag gaggaatcgg tacagactac agatacagcg ggatgagtct
     5701 tgcaaaggca gatgaaaaga tcgcagcatt gttgccagta gttgacactc tggcagcaac
     5761 agatacttat gaactgatgc agatttatga acttcgcgaa cgactgatcg tgtgccaggc
     5821 agtgatcgca catctggcag ccagaaagga aaccagatgg catagtttcg gagagaatac
     5881 agactacccg cagcagagcg aagagtggat gaaatatgta aactcccgta tggaaaacgg
     5941 cgagattaag atcttatatc gtgacctgat cacaaaggaa aatacaggtt tgaatacagc
     6001 agagaaagga gcaggtgaga gatgagcatt cggattcaga aaagtaaatg tgcaggatgc
     6061 ggcagatgta tcgaagcctg tcccggaaat ctgatcaaaa aggataaaga gaacaaagcc
     6121 tttatccgtc aggtaagaga ctgttgggga tgtacttcct gtattaagga atgcaggcat
     6181 gatgccatcc gcttcttcct tggagctgat gtgggaggca gaggtgcaag tatggttgta
     6241 tcagagaaac cggatatttc cacatggaca gtggagaaac cggatggcac taaaatcact
     6301 attcaggtta ataagaaaga cgctaataaa tattaaacat aagtatgtac tctcagagtc
     6361 tttagagtgt gtttgaaaaa tgctttacgc aagatgtgcg tcacaatttg tgggagattt
     6421 tgttcggatg agggcgtcgt agcgggctac gacaaccgaa ttcggacaaa atataccgca
     6481 aagtggggcg tgcagattgc gggaatgatt tttcagacac gctctagtgt atttgctcaa
     6541 gtacgaaaag attccgagta taaacaaaca gaggaggata atgcaatgag taacttatct
     6601 catcttgatg cgcttgaggc agaggcgatt tatattatgc gggaagtagc agccgagtgt
     6661 gaaaagccgg ttatgctcta ttctatagga aaggacagct ccgttatgct ccatctggcg
     6721 atgaaggcat tttacccgga gaaaccgcct tttccctttc ttcacattga tactacatgg
     6781 aaatttcatg agatgatcga attccgcgac agaatcgcaa aggaaaacgg aattgatatg
     6841 ctggtttaca ccaatgaaga gggtgtaaag gcaggaatca acccatttga caatggttct
     6901 gcatatacag atatcatgaa aacacaggcc ttaaaacagg ctctgactaa atatggattt
     6961 acagcggcat ttggaggcgg ccgtcgtgat gaggagaaat ccagagcaaa agaaagaatc
     7021 ttctctttcc gtaattcagc tcaggcatgg gatccgaaaa accagagacc ggagatgtgg
     7081 aagctttata acactaagat ccagaaggga gagagtatgc gagtattccc aatttccaac
     7141 tggacagaaa aggatatctg gcagtacatt cagcgtgaaa atatcgaaat tgtaccgtta
     7201 tattttgcga aagaaagacc ggtcatctac agagacggaa atatcattat ggtggatgat
     7261 gacagattaa aactccgtcc gggtgaaaag attgaaaaca aaaaagtcag attccgtact
     7321 cttggatgct atccgcttac tggaggtatt gaatctgaag cagatactct ggatgagatt
     7381 attgatgaga cgttaagtgc tgtttcttct gaacgtacca gcagggtgat cgaccacgag
     7441 gcagcaggca gcatggagag aagaaagaga gaggggtatt tctaggatga aaggattatt
     7501 gaaatttatt acatgcggaa gtgtggatga tggaaaatcc actctgatcg gacatattct
     7561 ttatgatgca aagcttctct atgcagatca ggagaaagct ctggagctgg attccaaagt
     7621 aggaagcaga ggcggtgcca ttgattattc tcttcttctg gacggtctga tggcagagcg
     7681 tgaacaggga atcaccattg atgttgcata ccgttatttt acaacagata acagaagctt
     7741 cattgttgca gatacacccg gacatgaaga atatacaaga aacatggcag tgggtgcgtc
     7801 ctttgcagat ctggcagtta tcctggtgga tgcttcacag ggagtactgg tacagacaag
     7861 acgtcatgca agaatctgcg cattgatggg aatccgttac tttgtatttg cagtaaacaa
     7921 aatggatctt attgaatatg atgaaaaacg tttccgcgac attgagaatc agatcgcagc
     7981 actgatagaa gaactgaaac ttgccaatgt aactattatt ccggtatctg ccacagaagg
     8041 tgataacgtt acaaccaaat ctgacaatat gctatggtat aaaggtgagg cgcttctttc
     8101 ccatctggaa accgtagaca ttaaggaaga tacagagaag ggcttctata tgcctgtaca
     8161 gagagtctgc agaccaaatc atgagtttcg cggattccag ggacagattg aaaatggtgc
     8221 catcagggca ggcgaccttg tgactactct tcccagtaaa gaagaagctc atgtaaagag
     8281 tattcttgtt ggcgataaag aagttcagga agctgtacag ggacagcctg ttaccatcca
     8341 gcttgacaga gaagtagatg tttcccgcgg atgtgtactt accattgatt ccggcgcagt
     8401 tcttacagac tctgtggaag cagatatcct ctggatggat gacaatgctc ttacggatgg
     8461 caagaacttc tttgtaaaaa tcggtacaaa gatgatcccc ggcctggtta caaagatcaa
     8521 ttattctgtg gatgttaata caggtgaaaa gaaaagcgca tataccttaa agaaaaatga
     8581 gattgcttcc tgtactctgg aattctcaga gaagatcgtt gtagacgaat ttgacaagca
     8641 cagaacactg ggtgagctga ttctgataga tcgtgtcaca aatatgactt ctgcctgcgg
     8701 tgttgtgaga aaaacctttg tttctcagga tagatcccag atcggaaaag tggacgagca
     8761 ggttcgtgca ggactgaaag gtcagacacc ggtagtagtg gaattcccga tcggtaaaga
     8821 aggaatcact cttgattttg cagagcaggt agaaaaggga ctgactgtac ttggaaaaca
     8881 tacctatctg tatcatccgg cagcgagtga aaactatgca gaaactgtcc gccatcttaa
     8941 ggcagcaggt ctgatcgtac ttcttgttct tgatgaaaat acagcaaaag acgagacatt
     9001 aaagactctg gatggtttct atgcgaactg gcagattgac ggaatcactg tgaaagatgc
     9061 gattgatttc gtgaaaaaga aatctgcatt tacagtgcag agtgtacatg atggaaatta
     9121 tatctgatta taacagggct ataaatcgcc gcagagacaa agaaagtctc tgcggtattt
     9181 tgttttcttg acaagtgtcg ttacagcgga ttatacttat tttcaaatat tcagaatcca
     9241 taataataca gacaggaaag ataacagaaa tatgcaaacg aacaatgaaa gtaaacaaaa
     9301 ccaaaaaaag agatgatgct tggaactttg tttgtaattg ctacgatcat catcctggcg
     9361 ataccaacga agaaaagaca gaaataaaga tgagtgaata tcgatcagaa tgtagaatgg
     9421 gcaattggtt actgttcaca caccactatc ccgcgaggtg ttttggcatg aatatgctaa
     9481 aatcccgaga cctacaagcc aaaattctat tgccacaggc aatctgaaat gaattttggc
     9541 taagttactg taaacggagt gaacagtaac ggcaattgtg aagtggcatt cagattacat
     9601 attatgcagc agagtatgat ataattcgtt ttgtataatg gcgtcaggat taagagcata
     9661 tgtagagctg tgtagcgaag cggattgcga atatctgttt gacttttgat gggtgtacac
     9721 gagaacattt ttttacagtg aaagttatct gtattatatt acagaaggta ctgtacagat
     9781 aatcaggagg tattttatgc gtttggaaaa agtacaggaa gcgttaaaaa caaagaaaat
     9841 tcattatgaa tatacagagg aaaatggatg cggaagcatc gactttatgt ttcgcggtct
     9901 gagattccat atatgggaat atgaagatcg tgtctgggga gcggagacaa acgtgttcga
     9961 agcaggcaga agccaggata ttgagggaga ttacgaggaa attatttccg gagaaatcct
    10021 ctcatggccg gatatgctgc ctgggatgta agtattactg cagaagggaa tgatatttac
    10081 gaaaaaatat agaaccggac aaattgtatt aactgcatgt attgtagctg tctgtatgtt
    10141 ttcaaatgtc catgggacag aagcggcagg tccgcctgca ccgaaaactc tgacagttac
    10201 accgacagaa aaatcgaaat caacagaaaa gttaaagtcc acgtcaacat caaagtccaa
    10261 atcaacaccg aaatccaaat cggcactaac acaaaaacct gaagcaacac caatacctgc
    10321 atctactcca acaccagagc aggaagctga gacagataaa cagaatccgg cagatcaggg
    10381 aactttaagc aagccagatc atccggatac tatctccgca gataaactgg tatttatcgg
    10441 agattccaga acagagggat tgagggatgc ggtaaatgat gacagcattt ggtcctgtct
    10501 ttcttctatg ggatatgact ggatggtatc tacaggagtg ccgcaggtag aagatcagat
    10561 tgaggacaat acagcggtta ttattctgat gggtgttaat gacctgtatc atgttaatga
    10621 ctatatcagc tatattaatt ccaaagctgc cgaatgggga aacaggggag cgcagactta
    10681 ttttgtgtct gtaggtccgg tgcagaatga tccctattgc agtaatgcgg agattgaaag
    10741 cttcaatgcg gcaatgcagg caaatctgag cggggttacc tacatagatg tatattccca
    10801 tctggtatct gagggatttt ccaccgtaga cggaacccac tatccggaca gtgtgtctgt
    10861 agatatttat aattatattc tggatcatct ggaggaacag aggagtggaa tctggggatg
    10921 atttttcagt ttatgaaatt gtgatgctgt attgagttcg atggagtttg gtgatatgat
    10981 tgcagaggaa aaaacgaaat agagcggaaa ttcgtttttt tatataaaag ctgaaaacct
    11041 ggtaggagga aataatgggt ggctgttttg cagcagagcc aaaaatgtaa atgataattg
    11101 cccaatgact ggacagttat caaaatccaa aatcaggagg aaagaatgag aggactgtat
    11161 tcatccaaaa cagaaatcag acacaaaatt tttacggaaa ttgcgaggat ggcatatgaa
    11221 ggccagtctc cggagatgct ggaagagctt ccctacaaga tcgtacccgg tgaaattgcg
    11281 acttatcgtg acagtatttt tctggaaaga gcggtagttg gtgagagact tcgtgttgca
    11341 atggggatgt cactgagaaa ggttacagag catgcgccaa tctccaaagg tgtggaagcc
    11401 agcgttattg aggaaaagta ttatgaaccg ccgcttatca atgtaatcaa gtttgcctgt
    11461 aattcctgcc ctgagaaaag ggtaatgatc acagagggct gtcagggctg tctggagcat
    11521 ccctgtgtgg aggtctgtcc aaagaaagca gtacatatgg aaggcggcag atcacatatt
    11581 gatgaagatg cctgcatcaa atgcggaaag tgtctggaag cctgtccgta taatgcaatc
    11641 atcaaacagg aacgtccctg ttcaaaggcc tgcggcatga atgccattgg atctgacgaa
    11701 tatggaagag cggagattga ccaggacaaa tgtgtatcct gcggacagtg tctggtgagc
    11761 tgtccgttca gcgctattgt agacaaagga cagattttcc agactgttat ggcattaaaa
    11821 agtgaaacac cggtgtatgc aatcgtggcg cctgccattg caggtcagtt cccgggtatg
    11881 gagaataata agatacgggg tgcatttcag gcacttggct ttacagatgt aagagaggtt
    11941 gcagtcggtg cagatctgtg cacagtggag gaggcaaagg actttttgga ggaagttcct
    12001 gagaaacttc cgtttatggc tacatcctgt tgtccgtcct ggtctatgat ggctaagaaa
    12061 ttattcccgg aacaggcgaa atgtatctcc atggcactga cacctatggt tcttactgcc
    12121 agactgatca agcagaagga accgaattgt aagatagttt tcgtaggtcc ctgtgcagcc
    12181 aagaagctgg aagccagccg taagagtatc cgcagctatg tggattttgt gctgaccttc
    12241 gaggaagtag caggaatgtt tgatgccaaa ggcgtggact ggaaagatat tccggaagga
    12301 gaaccactgt ttcgtgccag tgctgacgga agaggtttcg cagtcagcgg tggtgtggca
    12361 gaagcggttg tccatgcggt gaagcgtatt gatcctgatc gggaagtaaa ggtaatgaat
    12421 gcagaaggtc tgcagaactg taagaagatg ctccagatgg ccaagattgg taaatataat
    12481 ggatatctgc tggaaggaat ggcatgtccg ggcggctgtg tagcaggtgc cggtactatc
    12541 cagacagtta aaaaagcagc agcggctctc gaaaaaatga agaaagaggc ttcgtttaca
    12601 gatgcctatg actccaaata cagagcaaga ctggaaagtc tggagaaatt tgatgtggag
    12661 tgagatcctg actgaatcag tgaaatccta tatggattgc aagtgtttga atgcaatcag
    12721 tatatagcag agtgaattac tcggcaactg agttaccaga gcatctgaat taaggcggga
    12781 taccgccttt tttcagggtg catccatgac accactactg tttgctcttt agagttatac
    12841 agctactttt attatttccg gtgttttcag tccggttacg gacagttctc tttttactcc
    12901 ggatacggag tgatattttc tcaggatatt atatgcgcct acggcatctg cgttataggt
    12961 tctgtttcca tctctg
//
