LOCUS       c00284_gnlPro..        13392 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GJDMADOB_284.
ACCESSION   c00284_gnlPro..
VERSION     c00284_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:22:13
            Original ID  :: gnl|Prokka|GJDMADOB_284
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13392
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13392
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3392](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3392
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13392
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13392
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             3..3392
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg284_1"
                     /sec_met_domain="HGD-D (E-value: 7e-64, bitscore: 206.4,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1.2e-37, bitscore:
                     119.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPLFASQEEYDTIAKRQSSYKVKTGDLATYKGNCYLGIDAGSTT
                     TKTALVGEDGTLLYSFYSSNNGNPLKTTIRSIKEIYELLPEDAKIAYSCSTGYGEALIK
                     AALILDEGEVETVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTVDSVQLNEACSSG
                     CGSFIETFAKSLNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQAQKEGAEVSDISA
                     GLAYSVIKNALYKVIKVSDASELGRHIVVQGGTFYNDAVLRSFEKIAGCEAIRPDIAGI
                     MGAFGAALIARERHQEGAETSMLSIDKINELKYTTSMANCRGCTNNCRLTINKFSGGRQ
                     YVSGNRCERGIGKEKNKDHIPNLYEYKYKRIFSYAPLTADKATRGKVGIPRVLNMFENY
                     PFWYTFFTELKYEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGHVTWLIRNGVKFI
                     FYPCIPYERNEFPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRNPFLAFTSEEILA
                     NRLIEEFKDIPAEEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDTGRHGIVLAGRPY
                     HIDPEIHHGIPDLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHSRLYAAANYVKTR
                     DDLDLIQLNSFGCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGAARIRIRSLIAAI
                     RAKKAQGQKRTVKPASIDKVSFTKEMRKDYTILCPQMSPFHFSLLQAAFNSCGYNLEVL
                     PNDNKHAVDVGLKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVVMSQTGGGCRASN
                     YIAFIRRALKKAGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGAVFGDILMKCVYR
                     MRPYELEEGIVNRKHKIWEQRVISFLSGSSISHSQFKKMCREMVHEFDTIPISDVKKPR
                     VGIVGEILVKFLPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQNFKVENLGFKKSK
                     ATMANWGIKAIEWVRKPASEALAQSRHFAPPADIRDLAKMASPIVSTGNQTGEGWFLTG
                     EMMELIHGDVPNIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAIDYDPGASEVNQL
                     NRIKLMLSTAQKNLKKAEKKDA"
     CDS             complement(3494..5122)
                     /locus_tag="ctg284_2"
                     /transl_table=11
                     /translation="MNQKNNLVKNASFLMIAAMISKVIGLLYKSPLSNIIGSLGMGYTS
                     LAQNAYMILLMIASFSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFC
                     LFGAGLIIPQNQKDAIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFN
                     AAVSLLAAWGFINAFSDGTENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILH
                     RVERDHRHQEESYKEIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQI
                     GILYAEYATYFMTIINIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVV
                     SAPCAMGLAVLAQPIVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRI
                     PVITAAIALVVDIVVVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPW
                     KEGYLYPVLASVPMGIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSE
                     SQLRRIPGGSYLIRIAEKLPFWQNN"
     CDS             complement(5168..5842)
                     /locus_tag="ctg284_3"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             complement(5875..6633)
                     /locus_tag="ctg284_4"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             complement(6635..7273)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg284_5"
                     /sec_met_domain="GATase (E-value: 5.2e-31, bitscore: 97.8,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYDAGNIKSVEKALHYLGEETTVTRDPQTLLNADKVILPG
                     VGSFGQAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTYVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK"
     CDS             complement(7493..9037)
                     /locus_tag="ctg284_6"
                     /transl_table=11
                     /translation="MTGTGKTDKKFHTLQHQISVVFICLLLLSIFTITLINGLFLEKYY
                     VSKKVEVLEEAKEVLSQMNLDDILQYDTDIEEDKKGATDEISDEIERSSSRNNLTWIIV
                     NEENSGYYYWGENNMAKMLRSKLFGYINNLDQDMQHSRVLKKTDTCTMWQVHDRFAGME
                     YVECWGQFDNGYYFLIRSPLESIKESASISNSFYFIVGIIIIVVSGIVILVMTNRITRP
                     ISELTKLSEKMSDLDFDARYQSRAGNEIDVLGDNFNKMSRKLESTISELKSANNKLQKD
                     IEDKIKIDEMRKEFLDNVSHELKTPIALIQGYAEGLNENISDDPESREFYCEVIMDEAS
                     KMNKLVKNLLTLNQLESGKDAPVMERFDIVSLIRGVLGSMHIMIEQKEATVIFEETEPV
                     YVWADEFKIEEVVTNYTSNALNHLDGERKVEIKVLQEEDCVKVTVFNTGTPIPEEDIPN
                     LWNKFYKVDKARTREYGGSGIGLSIVKAIIESMNQKYGVCNYDNGVEFWFTLDCRQ"
     CDS             complement(9034..9714)
                     /locus_tag="ctg284_7"
                     /transl_table=11
                     /translation="MDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGEEAMDIFYE
                     EKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDLGVDEYISK
                     PFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPMELSFKEFELLT
                     YFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKTVWGMGYKF
                     EVDE"
     CDS             complement(10231..10467)
                     /locus_tag="ctg284_8"
                     /transl_table=11
                     /translation="MDLAGIEPASESLFIEASPITVAVLTFPWMYAHRQAYNLSSFMIH
                     LPGQSLPGKVSHMVDVRFLKCECIRADEQQLGC"
     CDS             10920..11468
                     /locus_tag="ctg284_9"
                     /transl_table=11
                     /translation="MALLKEESYTIEDIYALPDGERAELIDGHIYYMAPPSYKHQKLVM
                     ELSAIIRNYIKQHKGTCEVLPAPFAVYLDEINNTYVEPDISVICDPNKLDDKGCKGAPD
                     WIIEIVSPASRKMDYLLKLFKYRSAGVREYWIVDIAKNRITVYNFNHDYSIEEYSFTDT
                     VKAGIYEDLSIDFSEINIL"
     CDS             complement(11709..12716)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg284_10"
                     /sec_met_domain="Fer4_17 (E-value: 6.3e-13, bitscore: 39.1,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00015, bitscore: 12.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVTLGKTGLRVSRMGLGGIPIQKIDAEGTKTLLHKLADRGVNY
                     IDTARGYTVSEEYLGYALEGIRDRFIIATKSMARTKEAMAEDIEKSLHNLRTDHIELYQ
                     VHNPSMEQLDQVQAAGGALEALQEARAAGKIGHIGLTAHSVEVFARALELDWVETIMFP
                     YNIVESQGEELISKCEEKNIGFIDMKPLAGGAIENGTLALRYVCSNKNVTIVIPGMAEE
                     KEIEENIKACLDDSPLSEKELEEVQTVRNQLGTNFCRRCNYCAPCSVGIDISGVFLFAG
                     YLNRYGLGDWARNRYSSLAVKASACIECGKCETRCPYHLPIREMLKECAQQFGE"
     CDS             complement(12833..13390)
                     /locus_tag="ctg284_11"
                     /transl_table=11
                     /translation="MISAGDFKNGITLEIDGNVCQIVEFQHVKPGKGAAFVRTKYKNII
                     TGSVLEKSFRPTEKFPAARIERVDMQYLYDDGDLYYFMNVETYDQVGLTKDQVGDSLKF
                     VKENEMVKICSHNGNVFAIEPPLFVELEVTETEPGFAGNTAQGATKPATVETGAQVQVP
                     LFVNQGDKLKIDTRTGEYLSRV"
ORIGIN
        1 gtatggaacc actttttgct tctcaggaag aatacgatac aattgcgaaa cgtcaaagtt
       61 cctacaaagt aaaaacagga gatctggcta catataaagg aaactgctat ctgggtattg
      121 atgcaggttc caccacaacc aaaactgcac tggtaggtga agacggaaca cttctctatt
      181 ccttttacag cagcaacaac ggaaacccgt taaaaactac cattcgttct attaaagaga
      241 tttacgaact gcttcccgag gatgcaaaga ttgcttattc ctgttctaca ggttacggcg
      301 aggctctgat taaggctgct ctgatcctgg atgagggcga ggttgaaacc gtatcccatt
      361 actatgcagc agcgtttttt gacccggagg tagactgtat cctggatatc ggcggacagg
      421 atatgaaatg tatcaagatc cgcaacaaaa ccgttgacag cgtacagttg aatgaagcat
      481 gttcctccgg atgcggttcc ttcattgaaa cctttgccaa atccctgaat tatacagtac
      541 aggatttcgc aaaagctgct gtttttgcac agcatcctat agatcttggt accagatgta
      601 ccgtatttat gaattccaag gtaaagcagg cgcagaaaga aggtgccgag gtttccgata
      661 tttccgcagg tctggcttac tctgttatca aaaatgctct gtataaggtt atcaaggttt
      721 ctgacgcttc cgaacttggc agacacattg ttgtgcaggg tggtaccttc tacaatgatg
      781 cagttctgcg aagcttcgaa aagattgcag gctgcgaagc catccgtccg gatatcgccg
      841 gaatcatggg tgcattcggt gctgcactga ttgcccgcga acgccatcag gaaggcgcag
      901 aaactagtat gctctccatt gataagatca acgagctgaa atatacaact tctatggcaa
      961 actgtcgtgg atgtaccaat aactgccgtc tgactatcaa caaattctcc ggcggccgcc
     1021 agtatgtaag cggtaaccgc tgcgagcgtg gtattggcaa ggaaaagaac aaagatcata
     1081 tcccgaatct ttatgaatat aaatataagc gtattttctc ctacgcaccg cttactgctg
     1141 ataaggcaac gcgaggtaaa gtaggtatcc cccgtgttct gaacatgttt gagaattatc
     1201 ctttctggta tactttcttt acagaactga agtatgaggt tgtgctctct cctacttcca
     1261 ccagaaagat ttacgagctg ggtattgagt ccattccaag tgaatctgaa tgctatcctg
     1321 ccaaacttgc ccatggccat gtaacctggc tgatccgcaa tggcgtgaaa tttattttct
     1381 acccatgtat cccatatgaa cgtaacgagt tcccggatgc agtcaaccac tataactgcc
     1441 cgatcgttac ctcatatgcc gaaaatatca agaataacgt agacgaatta aacgatccgt
     1501 ccattacctt ccgcaatccg ttccttgcat ttacttctga ggaaattctg gcaaatcgtc
     1561 tgatagagga atttaaggat atcccggcag aagaagtcaa agctgctgtg cataagggct
     1621 gggaggaaat ggctgctgca cgccgcgatg tacagaaaaa aggggaagaa accctgaaat
     1681 atctggaaga tacaggacgc catggtattg tccttgcagg acgcccatac catattgacc
     1741 cggaaatcca tcatggtatc ccggatctga tcaacagcta tggtattgcc gtacttactg
     1801 aggattccat ctctcatctg gcacctgtgg aacgcccgat ccgcgtcaat gaccagtgga
     1861 tgtaccactc cagactgtat gctgctgcaa actatgtaaa gacacgcgat gacctggatc
     1921 tgatccagct caactctttt ggatgtggtc tggatgcagt tactactgac gaggtttatg
     1981 aaattcttga cggaagtgac aaaatctata cctgcttaaa gattgacgag gtaaataacc
     2041 ttggtgctgc aagaatccgt atccgttccc tgatcgcagc gatccgtgcg aagaaagcac
     2101 agggacagaa acgtactgtc aaacctgctt ctattgataa agtatccttt acaaaggaaa
     2161 tgagaaagga ctataccatc ctctgcccgc agatgtcacc gttccatttc agcctcctgc
     2221 aggcagcatt caattcctgc ggatacaacc tggaggtgct tccgaatgac aataagcatg
     2281 cagtggatgt tggtctgaag tatgtaaaca atgacgcctg ctatccgtct ctgatcgttg
     2341 tgggacagat catggatgct ctgctttccg gtaaatatga cctgaacaaa acggccgttg
     2401 tcatgtcaca gacaggtggc ggatgtcgtg cttccaacta tattgcattt atacgacgcg
     2461 cattaaagaa agccggtatg gaacagattc cggttatctc tgttaactta agcggtctgg
     2521 aaagcaatcc cggattcaaa cttacgcttc cattagtgaa gaaagttgct tacggtgccg
     2581 tattcggaga tattctgatg aaatgcgtat atcgtatgcg tccttatgaa ctggaagagg
     2641 gaatcgtaaa caggaaacat aaaatctggg aacagcgtgt gatctctttc ttaagcggaa
     2701 gcagtatcag ccacagccag tttaagaaaa tgtgccgcga aatggttcac gaatttgata
     2761 ccattccgat cagtgatgtg aaaaagcctc gtgtcggcat cgtaggtgag atccttgtca
     2821 agttcctgcc tgctgcaaat aatcatctgg cagagcttct ggaatctgaa ggcgctgagg
     2881 cagttgtacc ggatctgatc gatttcatgt gctactgctt ctataaccag aactttaagg
     2941 tagaaaatct tggattcaag aagtccaagg caaccatggc aaactgggga atcaaagcaa
     3001 tcgaatgggt gagaaagcct gcaagcgaag ctcttgcaca gagccgccat tttgcaccgc
     3061 ctgctgatat cagagatctg gcaaaaatgg catctccgat cgtttccacc ggaaaccaga
     3121 caggtgaggg atggttcctg acaggtgaga tgatggaact gatccatgga gatgttccga
     3181 atattgtttg tatccagcct ttcggatgtc tgccgaacca cattgtaggt aagggtgtta
     3241 tcaaagagat ccgcagagaa tatccgacag ccaatattgt agccatcgac tatgacccgg
     3301 gtgcaagtga agttaaccag ctcaaccgaa tcaaactgat gctctccaca gctcagaaaa
     3361 acctgaaaaa agcagaaaag aaagacgcct aaaataaaag agttatattt cagaaatttt
     3421 aaatgtgttt ctatttcaga aatacattta aaccatgaaa tataactctt ttatttttta
     3481 taacttctgt tttttaatta ttctgccaga acggaagttt ctctgcaatc cttatcagat
     3541 agcttccacc cggaattctt ctaagctgtg attctgacgg cttgctgatg atcaggtaag
     3601 caaacagata aacaaccgca gcaacaggaa tggaaacgat cagacaaatg aaattggatt
     3661 ttacaaaaat gttcagtcca tagcagatac agcctgcaac aattcccatg ggaacagatg
     3721 caagaacagg atacagatat ccttctttcc atggattctt atactgcaga tatttcttca
     3781 tggctctgtc atttaacaca cacacaacca cagaatagat caccattgcg atcagcagtg
     3841 cataaactcc aaggtttgta gtaaacagca gcactaccac taccacaata tccacaacca
     3901 gtgcgattgc agccgtaatc accggaatcc tctgctgtcc gattgcctgc agaactccat
     3961 tggaaatatt tgacattcca ttgagcagga tcgaaaaaga accaaggatc agcaggttgg
     4021 ctgccagtcc tgtggaattt ccgtaaagca aaaatacaat cggctgtgca agcactgcca
     4081 gtcccatggc acatggggca gaaactacca tagaaagctg tacggtctgg tcaatgcact
     4141 ctctggtcgc ttcaatgtct ccggtggcat acagggcgga aacttccgga atcatggaag
     4201 taggtgccgt actggacagc gtcagaggaa tattaataat tgtcataaag taagtagcat
     4261 actctgcata taaaatacca atctgtgccg catctccacc tcttcttccc agaatatccg
     4321 agaaaagata cccattgata taagcattta cattataaac aaaggcgctg agaatgatcg
     4381 gcgaaacaac caggatgatc acacgaaaaa tctctttgta ggactcttcc tggtgtctgt
     4441 gatctctctc tacccggtgc aggatttttc tgcggtttac accatatacc agaagcatga
     4501 atgccaatgc agtcaccact ccggctccgg ttcctactgt ggaacctgct gccccccatt
     4561 ttgcaatgct gttctctgtt ccatctgaga atgcattgat gaatccccag gctgccagaa
     4621 gactgactgc cgcattaaat acctgctcaa tgatctggga gatagatgtt ggcatcatat
     4681 ttctgtatgc ctgaaaatat cctctgaata ccccaagaat accggacaaa aaaatcgtcg
     4741 gagccaggat ctgaagtgcc ggaattgcat ccttctgatt ctgagggatg atcagccctg
     4801 ctccaaagag acagaataaa ccgaccactc cgccaatcac catggcatag atcatggcac
     4861 ccttaaagaa cttatgtgca tttctgtaat ccttcagagc aatacgctcg gagatcagct
     4921 tggataccgc ctgtggaata ctaaaggatg cgatcatcag aaggatcata taggcattct
     4981 gtgcaagact tgtatagccc attccaaggc ttccgataat attggaaagg ggactcttgt
     5041 acagaagacc gatcaccttg gagatcatag ctgcaatcat cagaaaggat gcatttttta
     5101 ctaaattgtt tttctgattc atgttatcac tgtgtgtctt ttacctgact acacattacc
     5161 tcttttctta tatattttct atctgccagt cgattggttc cagaccattg gcaacaagaa
     5221 attcgtttgt tttactgaaa tgtttacatc cgaaaaatcc cctgtaagca gacagaggac
     5281 ttggatgagg cgcctccaga atcagatgct tcggattatt cagcatggat tttttcatct
     5341 gcgccggacg tccccagagc agaaatacaa taggacggtc ctgctcattc agaacctgga
     5401 tcgcagcatc cgtaaactgc tcccagccga tccccctgtg tgaatttgcc tgatgggcgc
     5461 gtacagtcag aactgtgttc agaagaagca ccccctgctt cgcccacttc tccagatagc
     5521 cgttattggg gatatagcat ccacagtcat catgaagctc ctgataaata ttcaccaggg
     5581 acggtggcgt ctccactcct ctctttacgg aaaaacaaag cccatgagcc tgcccgtcat
     5641 tatgataggg atcctgaccc agaatcacta ccttcacttc attcaacggt gtaaaatgaa
     5701 atgcattaaa cagatcatcc gcaggaggaa aaatcttcct ggtctgatat tctgtcatca
     5761 ccgttttata taatttcgca taatacggct ggtgaaactc ccccttcagg gcttccagcc
     5821 agtcacctga aattgctgac ataccttatc cttcacctct tatatttttc gtggtcatcg
     5881 tctgacagaa attcccctat cagacagata atccttcacc tgagaaatct ccagttcttt
     5941 ataatgaaac aaagacgcag ccagtgcagc atctgctccc ccttcggtca gtgcatcata
     6001 aaaatgctcc agtgtacctg caccgcctga tgcgatcaca ggaatggaga cagcatcagc
     6061 gattgctctg gtaagagcca gatcatatcc tgcttttgta ccgtcacagt ccatactggt
     6121 aagaaggatt tcccctgcgc ccaaagcttc cactttcttt gcccactcta tggcatcaat
     6181 ccctgtatcc agtcttccgc catgtttgta aatattccat ccgccgtctt ctctgcgctt
     6241 ggcatcaata gccacaacta cgcactggct tccaaacttg tcagccgcct cactgatcag
     6301 ttccggtctg tcaattgctg cagaatttac ggaaatctta tctgctcctt ctctcagcag
     6361 tttcttgaaa tcatctacag tacggatacc gccgcctact gtaaacggga taaatacatt
     6421 ggcagcaacc cgtcttacca tgtcaactac cgtatctctc tgttcgcagg atgctgtaat
     6481 atcgagaaac accagttcat ctgctcctgc tgcatcatag gctttggcaa tctccaccgg
     6541 atcacccgca tcgcgaagct gcacaaaatt tacgcccttt accacacgtc cgttatttac
     6601 atccaggcag ggaataattc tctttgtaaa catcttattt tccctccttc tcagtattgc
     6661 cgtcttttcc cacagcagca aaattttcaa gtatcttcag tccccatttg ctgctctttt
     6721 ccggatggaa ctggcaggca aatacattgt ccttttctac ggaagcatga atacaggtgc
     6781 tgtattctgt agtagccttt acaatctcag gctcctctgc ctgcagataa taagaatgca
     6841 caaaatatac ataggtctgt tccgggattc cctgaaacag tctgccatta ttctgaaaat
     6901 gcagggaatt ccatcccata tgtggaatct taagccccgg cgcaggcgga atcttaacaa
     6961 ttttcccttt caggattcca aggccttcca cccccggtgt ctcctcgctg ctttcaaaaa
     7021 ggagctgaag tcccaggcag attccaagaa atggcgtctt cttctctaca atctcatgga
     7081 tcacaggtac aagtccgtat gtatgaagat tctccatcgc ctgtccaaag cttcccacgc
     7141 ccggcaggat tactttatcc gcatttaaca aagtctgcgg atcgcgggtt actgttgttt
     7201 cttccccaag ataatgaagt gctttttcta cacttttaat atttccggca tcatagtcaa
     7261 ttattgcaat catgttatcc tcctgatgtc attatctgtt ttcctcatta tggtaatcca
     7321 aagattttcc ggatcacatg tcagaccgga ataaaatatc cgatcaaaac gctccaatac
     7381 agtataaccc aaaaacagac agttgcaaag tgctttcttt gcttctgtct gtttttattc
     7441 cggtcatact accggttact gttcactccg ttcacaatac ccggatatct tatcactgcc
     7501 tgcaatccag agtgaaccag aactccacgc cattatcata attgcatacc ccatatttct
     7561 ggttcatact ctcaatgatt gccttaacaa ttgaaagtcc gataccactt ccgccatatt
     7621 ctcttgtccg ggccttatct actttgtaga atttattcca gagatttggg atatcctctt
     7681 ccggaatcgg agtacctgta ttaaatacgg ttactttcac acagtcctct tcctgaagaa
     7741 ccttaatttc tacttttcgt tctccgtcca gatggttcag tgcattgctt gtataattgg
     7801 tcacaacctc ttcaatctta aactcatccg cccatacata tacaggttct gtttcttcaa
     7861 aaatcacagt tgcttctttc tgttcgatca taatatgcat ggaaccaagt acacccctga
     7921 tcagagatac aatgtcaaat ctttccatca ccggggcatc tttaccggac tccagctgat
     7981 tcagcgtcag caggtttttg accagcttgt tcatctttga agcttcatcc ataataactt
     8041 cacagtaaaa ttccctgctt tccggatcat cggaaatatt ttcattcagc ccctctgcat
     8101 atccctggat caatgcaata ggagttttca gctcatgaga aacattatca agaaattcct
     8161 tacgcatctc atcaatttta atcttatctt ctatgtcttt ctgaagcttg ttattagccg
     8221 atttcaactc tgagatcgtg ctctcaagtt ttctggacat tttgttaaag ttatcgccaa
     8281 gtacatcaat ctcattacct gccctgcttt gatatctggc atcaaaatcc agatcagaca
     8341 tcttctctga taatttggtc agttcactga tcgggcgggt aatacgattt gtcatcacaa
     8401 gaatcacaat accgctgacc acaattatga ttattcctac aatgaagtaa aaactgttgg
     8461 aaatagatgc actttcctta atactttcca gaggagaacg gatcaggaaa tagtaaccat
     8521 tatcaaactg tccccagcat tccacatatt ccatgcctgc aaagcgatca tgcacctgcc
     8581 acatggtaca ggtatctgtc tttttgagca cacgactgtg ctgcatatcc tgatccagat
     8641 tattaatata cccaaacagc ttactgcgga gcatttttgc catattattc tctccccagt
     8701 aataataacc gctgttttcc tcatttacta taatccaggt aaggttattt ctggaactgc
     8761 tcctctcaat ctcatccgaa atctcatctg ttgccccttt tttgtcctct tctatatctg
     8821 tatcatactg caggatgtca tccagattca tctgagacaa cacttctttt gcctcctcca
     8881 gcacttctac ttttttggat acataatatt tttcaagaaa aagaccattg atcagagtaa
     8941 tggtaaagat tgaaagcagt aacagacata taaacactac tgaaatctga tgttgcagag
     9001 tatgaaattt tttatctgtt tttccggttc ctgtcattcg tctacctcaa acttgtatcc
     9061 cataccccat acagtcttta tatattcacc tttatctccc attttacttc tgagcttctt
     9121 aacatgggta tcaatcgtac gggcatctcc aaagtagtca taattccata cagaattcag
     9181 gatcttttct ctggaaagtg cgattccctg attctccaga aaatatgtca gaagttcaaa
     9241 ttccttaaag ctcagttcca taggcttacc atccacagta gccagatgtg ctgctttatc
     9301 tataacaatg ccacctgctg aaatcacatc ttccggatta ttctgacctg tacgtctcag
     9361 aattgcctcc actcttgcaa caaggatttt cggactgaat ggtttagaga tgtattcatc
     9421 tacccccaga tcaaatccaa gaagctcatc tctctcatca cttcttgcag tcagcataat
     9481 aatcggaact tttgagttct tgcgaatctc acggcaaact tcccatccat ccatcttcgg
     9541 catcatgaca tccaaaatga tcagtgcgat gtccttctcc tcataaaaga tatccatggc
     9601 ttcttcacca ttaccggctt ccagtacctg gaaattcttc tttgtcagga aatcctttac
     9661 cagctttctc atgcggctct catcgtccac caccaggatt tttaatgtat ccatttgatc
     9721 ccctccgttt ttcttcatta ttttccgaaa cagtttttac tttttattta tactgttttc
     9781 cgagtattgt taaaatccac gactgttcag cgcctttaca gccacagcgc aaaatccggg
     9841 aaaatcgccc tcagcaacag attttatctt tcatatggtt actatagcag agatttatgt
     9901 aagatttgtg aacatatgac agaaaaatta taagtattgc tgttcacaac accaaatagc
     9961 ctcaaatata aaaatcttct tgacaaattc tgtttttatt tctatactgt taatcagtcg
    10021 atatatctta tataatgaat gatatatcaa tattaaaaag tgctttcgtc tcatcaccag
    10081 tgctgtttta tgaaaaaaca gcgttgcaga ctcattttca gggcttgtac tggtttcgac
    10141 gggggctttg aagttgggga agccatccgc agactcccag actgcgtacc aaccgggaaa
    10201 ctaaatataa acgcagacga acagtacgcg ttagcagcct aattgctgct cgtcagccct
    10261 gatgcactca cacttcagga atctgacgtc gaccatgtga gaaaccttgc cgggtaagct
    10321 ttgccccggt agatgtatca tgaagctact aaggttgtaa gcctgtcggt gggcgtacat
    10381 ccaagggaat gttaaaacag cgactgtgat gggagatgcc tcaatgaata ggctttcgga
    10441 cgcgggttca attcccgcca ggtccataaa attccttgat tttataaagg ttttatctct
    10501 tggttttttt aagtaagcag aaagtaagca agcaagtgta atcaaggcat gataaagagt
    10561 ttatccacaa agtgatactt tacggataag ctctttttta tagtctgatt cgcttacatc
    10621 atatgtgtag aaattttcat ttacttctgg tgtgtttcca atcagggcag cagttgttac
    10681 tgaatctgca ccatttacac gcatacgtga atttaaggtt ctgcgaatag cgtgtatact
    10741 tttgactggg atttttgcct gtgcacattt atatcgggca cattcagaaa tagattctgg
    10801 tgtacaatga cctgtgacag tagcaaatta caaatataaa aaagagctgc tgccagatgg
    10861 tcagtgttga atattttatg taaatccact ataatataat caaaaaggag cgtgatcgta
    10921 tggctttact caaagaagaa tcttatacca ttgaagatat ttatgctctg ccagatggcg
    10981 aaagagccga actgattgac ggacacatct attatatggc accaccatcg tacaaacatc
    11041 agaaactcgt catggagctt tccgctatca tccgtaatta tataaaacag cacaaaggaa
    11101 cttgcgaagt gcttcctgca ccattcgccg tatatcttga tgaaataaat aatacttatg
    11161 tcgaaccaga tatatctgtg atttgtgatc caaacaaact tgatgataaa ggatgtaaag
    11221 gcgcaccaga ctggattatt gaaattgtat cgcctgcaag cagaaaaatg gattatctcc
    11281 tgaaactttt caaatatcgt tccgcaggtg tccgggaata ctggatcgta gatatcgcaa
    11341 aaaacagaat tacagtatac aactttaatc atgattattc cattgaagaa tattcgttca
    11401 ctgatactgt aaaagctgga atttacgaag atttatctat tgatttctca gaaattaata
    11461 tcctgtaaaa tctaaaaaag ttggtaatac atcccttcta tatgggattt taccaacttt
    11521 ttattgtgct tgttccatgg catatccgac agtttgatta ccaaaacaca tctggtattc
    11581 tttatggtgc caaaggattt taatgatgat atcctcatct gctaccaatc gtcccacttt
    11641 cttttgagca aaaaagacac accatctcca tgaaaaacat ccacagggta attccctgtg
    11701 gatgtttttt attcaccaaa ctgttgtgca cattctttca gcatttcgcg gattggcaga
    11761 tggtacggac atctggtttc acatttgccg cattctatac aggcggaagc cttcaccgca
    11821 agagaactgt aacggtttct tgcccagtct cccagcccgt aacggttaag atagcctgcg
    11881 aacaggaaca cacccgaaat atcgattccc acactgcatg gagcacagta attacatctg
    11941 cggcagaaat ttgtgccaag ctgattccgt actgtctgaa cttcctccag ttctttctcg
    12001 cttaacgggg aatcatcaag acaggccttt atattctcct cgatttcctt ctcttccgcc
    12061 attcccggga tcacaatagt aacgttctta ttcgaacaga cataacgcaa tgccagcgtt
    12121 ccattttcaa ttgcaccacc ggccagaggt ttcatatcaa taaagccgat gtttttctcc
    12181 tcacattttg agatcagctc ttccccctga ctctctacaa tattatatgg aaacataata
    12241 gtttccaccc agtcaagctc cagagcccgg gcaaaaacct ccacagaatg agcggtcaga
    12301 ccaatatgtc cgatttttcc tgctgctctt gcctcctgca gtgcttcaag ggcaccaccg
    12361 gccgcctgca cctgatcaag ctgttccata ctcggattat gcacctggta taattcaata
    12421 tgatctgtac gaagattatg aagactcttc tcaatatctt cagccatagc ttcctttgta
    12481 cgtgccatgg actttgtggc aattataaat ctgtccctga taccttccag tgcatatccc
    12541 agatattctt cactgaccgt atatcctctg gctgtatcaa tataatttac tccccggtct
    12601 gccagcttat gcagcagtgt ctttgttcct tccgcatcaa ttttctggat cggtatcccg
    12661 ccaaggccca ttctggaaac cctgagaccg gtttttccaa gcgttacata ttccatattt
    12721 tttctcctat tttcaatcag agataaaaaa ctgccaccgg atcttaccga tggcagtttt
    12781 tatctcttta catctgtcga tcagacaaaa caaacaactg gtttcatcct gattatactc
    12841 gagaaagata ttctcctgtt cttgtatcga ttttcagttt gtcgccctgg ttaacgaaca
    12901 gcggaacctg aacctgtgca cctgtttcta cagtagccgg ttttgtagca ccctgtgctg
    12961 tatttccggc aaatcccggc tctgtctcag taacttcaag ttctacgaac agaggaggct
    13021 caatagcaaa tacatttccg ttgtgggaac agatcttaac catctcgttc tctttaacga
    13081 atttaagaga atctccaacc tgatcttttg taagaccaac ctgatcgtat gtctctacgt
    13141 tcatgaagta gtacagatca ccatcatcat acagatactg catatctaca cgctcaatac
    13201 gtgcagccgg gaatttctct gttggacgga aagacttctc aagaactgat cctgtaataa
    13261 tgtttttgta ttttgttctt acgaaagcag caccctttcc tggttttacg tgctggaatt
    13321 caacgatctg acatacgttt ccgtcaattt caagtgtgat accgtttttg aaatcacctg
    13381 ctgaaatcat ag
//
