LOCUS       c00322_gnlPro..        12074 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GJDMADOB_322.
ACCESSION   c00322_gnlPro..
VERSION     c00322_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:22:13
            Original ID  :: gnl|Prokka|GJDMADOB_322
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12074
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12074
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1904:12072]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1905..12072
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /neighbourhood="10000"
                     /product="GR_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12074
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /kind="single"
                     /product="GR_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12074
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="GR_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [Gly_430_pcre, Gly_8-9_TMA,
                     Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol,
                     PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline,
                     PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..356
                     /locus_tag="ctg322_1"
                     /transl_table=11
                     /translation="PEDGISSSVKIGLNASLDAEAVLFTVYDPPWLTSETICELIHVFL
                     NTSKGIAFVSCQGKMGNPCIFDGKYYNELLSLEGDKGGKKVIMKHLDDTQIYEIEAGRE
                     LEDIDYYESIAVH"
     CDS             complement(759..1703)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_kinase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg322_2"
                     /sec_met_domain="AA_kinase (E-value: 2.7e-37, bitscore:
                     117.9, seeds: 128, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTRKRIVIALGGNALGNTLPEQMVAVKTTAKALCDLIEEGHQVV
                     VVHGNGPQVGMINNAMSALSREDENQPNTPLSVCVAMSQAYIGYDLQNALREELRIRGF
                     VRTPVVTVVTQVRVDPNDPAFENPSKPIGKFLTKEEADHQAKAYGHIMKEDAGRGYRRV
                     VASPKPVEIVEQDAINSLVDANKIVICCGGGGIPVVLNGHHLKGASAVIDKDYASCLLA
                     KELDADMLIILTAVEKVAVNFGKENEEWLDDITVDDAKKYISEGQFAPGSMLPKVQAAV
                     DFASSKEGRTAMITLLQKAKDGIQGKTGTKIHL"
     CDS             complement(1905..3098)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: OTCace"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OTCace_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg322_3"
                     /sec_met_domain="OTCace (E-value: 1.1e-49, bitscore: 157.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /sec_met_domain="OTCace_N (E-value: 3e-31, bitscore: 97.7,
                     seeds: 1463, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLQDYIDKLNSLNFKEMYNNDFFWTWDKTDDELEAVFTVADAL
                     RFMRENNISTKVFESGLGISIFRDNSTRTRFSFASACNLLGLEVQDLDEKKSQIAHGET
                     VRETANMVSFMADVIGIRDDMYIGKGHAYQKEFMEAVTEGNKDGILEQRPTLVNLQCDV
                     DHPTQCMADMLHIIHEFGGVENLKGKKIAMTWAYSPSYGKPLSVPQGVIGLMTRFGMDV
                     VLAHPEGYDVMPEVEEIAKKNAEKNGGSFTKTNDMAEAFKDADIVYPKSWAPFAAMEKR
                     TDLYAEGDFDGIDKLEKELLAQNAQHKDWACTEELMKTTKDGKALYLHCLPADITGVSC
                     ETGEVDASVFDRYRIPLYKEASFKPYIIAAMIMLSKFENPQDILKKLEVKAAPRILK"
     CDS             complement(3304..4614)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg322_4"
                     /sec_met_domain="Peptidase_M20 (E-value: 2.6e-25, bitscore:
                     78.6, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYAKINEAAMGYKDDMTKFLRDLVRIPGESCGEKGHIMRIKEEM
                     EKVGFDKVQIDPMGNILGYMGTGKTLIGFDAHIDTVGIGNIKNWEFDPYEGFESDEEIG
                     GRGTSDQMGGIVSAVYGAKIMKDLGLLNDKYQVLVTGTVQEEDCDGLCWQYIIHEDGVR
                     PEFVVSTEPTDGGIYRGQRGRMEIRVDVKGVSCHGSAPERGDNAIYKMADILQDIRALN
                     ENDAADTTEIKGLVKMLDEKYNPEWEEARFLGRGTVTTSEIFFTSPSRCAVADSCSVSL
                     DRRMTAGETWESCLDEIRALPAVQKYGDDVTVSMYEYNRPSYTDLVYPIECYFPTWVIP
                     KDHKVTQALEEAYKGLYGEERLGNAETEGMRKARPLTDKWTFSTNGVTIMGRNSIPCIG
                     FGPGAEAQAHAPNEKTWKIDLVRCAAVYAALPTAYCK"
     CDS             complement(4760..5989)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg322_5"
                     /sec_met_domain="PALP (E-value: 1.4e-52, bitscore: 168.1,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEGLKWTVNEVPKSDDKHLELMSEENVKKANEFHRSFPQYSVTP
                     LQNLSSLAKYLGVKNIFCKDESYRFGLNAFKVLGGSYAMGRYIAKELGRDISELPYNVL
                     SSDKLREEFGQATFFTATDGNHGRGVAWAAKRLGQKAVVRMPKGTTKTRFDNIAKEGAT
                     VTIEEVNYDDCVRMAAAEAAKTEHGIIVQDTAWDGYEEIPSWIMQGYGTLVLEADQQLK
                     EMGVERPTHVFVQAGVGSLAGAVVGYFAHKYKDNPPVMAVCEASAADCLYRSAVAKTGN
                     LVNVTGDLQTIMAGLACGEGNTIGWDILKNHVDVFASCPDWMSAKATRIYANPLGDDPH
                     VVSGESGSVPLGFCFTALHDEDAKDLKEALKLDENSVVLVISTEGDTDPVRYREIVWDG
                     LYGTNESLSK"
     CDS             6248..7489
                     /locus_tag="ctg322_6"
                     /transl_table=11
                     /translation="MAVFHAFRALRPTPEKAADVAALPYDVVNREEAKSIGDENPLSFL
                     HIDRPEMDLEPETDLYDDRVYEKAKENLDNMEEKGILVQDQKACYYIYELVRKGKTQTG
                     IVGCSSIDDYMNGVVKKHELTREDKEQDRIHHVDSCNANTGPIFLACRYPDFLLTLMNN
                     WKDHHEAAYDFTEEDQITHRVWVIDEDEVISEINKEFAGIDFLYIADGHHRAASAVKVG
                     LKRREQNPGYTGEEEFNYFLSVVFPYDQLCILPYNRIVKDLNGLTVKAFLGALKFNFEL
                     MLMPGFPCKPVEKHCMGMYVDGQWYHLKAWPDIYEKKDVVGQLDVSILQEKVLRPVLGI
                     EDPRTDQRISFVGGSHKAAELAEIADRTGGVAFVMYPTSMEDLMKIADENKLMPPKSTW
                     FEPKLRSGLFIHKL"
     CDS             7765..8133
                     /locus_tag="ctg322_7"
                     /transl_table=11
                     /translation="VEDAELRNILFSIQGSIAGFQNDMSDVKNDIADMKTDIANMKTDI
                     TNMKADITNMKSDIVQLKGSVKTIELKLENEIDRKISALFDARMDELRYRKENKETREK
                     VFELDMRVDNLEKAIMPA"
     CDS             8817..10472
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg322_8"
                     /sec_met_domain="HMGL-like (E-value: 3.2e-76, bitscore:
                     245.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMNPSKYQRQYFMPPVKCMKWAEKEYVDKAPVWCSVDLRDGNQAL
                     VIPMSLEQKIEFFKLLVKIGFKEIEVGFPAASETEYEFLRTLIEQNLIPQDVTIQVLTQ
                     AREHIIRKTFEAVKGAPKAIVHVYNSTSVAQREQVFKKSKEEILKIAVDGAALLKKLAD
                     ETEGNFQFEYSPESFTGTEPEYALEVCNAVLDVWQPTADNKCIINLPVTVQHSMPHVYA
                     SQVEYMCENLKYRENVIVSLHPHNDRGCGVADSEMGLLAGADRIEGTLFGNGERTGNVD
                     IVTLGMNMYSQGVNPKLDFSDMPHICEIYEECTGMKVGERSPYSGALVFAAFSGSHQDA
                     IAKGMHWRDDKDPDHWNVPYLPIDPTDVGRNYDADVIRINSQSGKGGVGYILETKFGLN
                     LPPKMREAMGYATKAVSDHKHKELHPDEIFNLFKQTFENITEPYSINEVHFQQKDGGIV
                     TKVTSTFRGKTITTEASGNGRLDAVSNALKKAYELKYSLETYQEHALERSSSSKAIAYV
                     GIKKPDGTLAWGAGVDADIIRASIDALVTAINNR"
     CDS             10879..12072
                     /gene_functions="biosynthetic (rule-based-clusters)
                     GR_AA_metabolism: PFL_acetate2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg322_9"
                     /sec_met_domain="PFL_acetate2 (E-value: 4.7e-167, bitscore:
                     546.2, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFEQWNGFKGNRWKEKIDVRNFIGMNYTPYDGDASFLEGPTEA
                     TNKLWGKLQALQKEERAKGGVLDMETEVVTSLTAYGPGYIDEETKDLEKVVGLQTDKPL
                     KRAFMPYGGIKMAEQACETYGYKVSDKIKDVFHNYEFKTHNQGVFDIYTPEMKVARHNK
                     ILTGLPDTYGRGRIVGDYRRVALYGIDALIEGKQKDFAACDRQGMRRYDFQLREEIADQ
                     IRALKGMKVMAESYGYDISKPAKDAREAFQWLYFGYLAAIKTQNGAAMSVGRISTFLDI
                     YIERDLQNGTLTEKEAQELVDHMVMKFRMVKFARIPSYNQLFSGDPVWATLEVAGMGQD
                     GRSMVTKNDYRFLHTLEDMGPAPEPNLTVLYSSRLPENFKKYAANISVTTSSVQYEND"
ORIGIN
        1 atccggaaga tggaatttct tcctctgtaa aaatcggtct gaatgccagc ctggatgcag
       61 aggcagtgct ttttactgtg tatgatccgc cctggcttac cagtgagaca atctgtgaac
      121 tgatccatgt gtttttaaac acttccaaag gaatcgcctt tgtttcctgt caggggaaaa
      181 tgggaaatcc atgtattttt gacgggaaat attacaatga gctgctttct ctggaagggg
      241 ataaaggcgg taaaaaagta atcatgaaac atctggatga tacgcagatt tatgagatag
      301 aagcaggcag ggaactggaa gatattgatt attatgaatc tatagcagtc cactagtaca
      361 tcgtttcgta aataactata ccaatcgcta ggatgcggat tcgagtgtgc tggtataaaa
      421 acgcaggcgt agcgggctac gctgaggctt ttagacctgt gcaatcggat tcgcagacaa
      481 gtgagtggta tagttatttc gaaaacgatg tactagagcg tgtctgaaaa tgctttccgc
      541 aagatgtatg tcaaaatata ccgaaaagtg gggcgtgcag attgcaggaa tgattttcca
      601 gacactctgg tccattcatc acaaaaaaag ttccgggcga ggtcaccgga actttttttg
      661 cgcaattatt tcgctatata gcagatatcc tgaatatgtg gcagttatat atatcagtat
      721 taaacagctg atatataata agatatctgc tgaacagatt aaagatggat tttggttccg
      781 gtttttccct ggataccgtc tttggctttc tgaagtaaag tgatcatggc agttcttcct
      841 tctttggagc ttgcaaaatc aacggcagcc tgaactttcg ggagcatgga acctggggca
      901 aactgtccct cactaatata tttcttagcg tcatctacag tgatgtcatc cagccattct
      961 tcgttttcct tgccgaagtt tacagcaacc ttctccactg ctgtaagaat aataagcata
     1021 tctgcatcca gctctttggc caggagacag cttgcataat ccttatcaat aactgctgat
     1081 gcacctttga gatgatgtcc gttaagaaca acgggaattc cgccgccacc gcagcagata
     1141 acgattttat ttgcatccac aagactgttg atcgcatcct gttcaacgat ttcaacaggc
     1201 tttggagatg caactacacg acgataacca cgccctgcgt cttctttcat gatatgtcca
     1261 tatgccttgg cctgatggtc tgcttcctct tttgtcagga atttgccgat cggcttggat
     1321 ggattttcaa aagcaggatc attgggatct acacgaacct gagtgacaac agtgacgaca
     1381 ggtgtgcgga caaatcctct gattcgaagt tcctctctca aagcattctg cagatcatat
     1441 ccgatgtaag cctgactcat ggcaacacag acagagagag gagtgtttgg ctgattctca
     1501 tcttctctgg agagagcaga catggcattg ttgatcatgc caacctgtgg cccgtttcca
     1561 tgtacaacaa caacctgatg accttcttcg atcagatcgc ataatgcttt tgcagtagtt
     1621 tttacagcta ccatctgttc cgggagagta tttcccagag cgttcccacc gagcgcaata
     1681 acgattcttt ttcttgtaaa catttgtaaa aacctcctga ttttaaaggc aaagagggcc
     1741 gccgcaataa agattgtgtg ctttctgcga cagccccgcc tgctatacaa tatgatgagt
     1801 gttatttttc aatatattta aattctgaaa ctgatttcaa aattaaatat ctgtttgaaa
     1861 gcagctggaa tattactgca atccaactgt taatctgcgc ctgattattt caggattctt
     1921 ggagctgctt tgacttcaag tttcttcagg atatcctgtg gattttcaaa tttggaaagc
     1981 atgatcatag cagcgatgat gtatggtttg aagcttgctt ctttgtataa cgggattctg
     2041 taacgatcga atacagaagc gtcaacctca cctgtttcgc agcttacacc tgtaatatca
     2101 gccggcaggc agtgcaggta aagagctttt ccgtcttttg ttgttttcat aagttcttct
     2161 gtgcaggccc agtctttgtg ctgtgcattc tgtgcaagaa gttctttctc taatttatcg
     2221 attccgtcga agtcgccttc tgcataaagg tctgtacgtt tttccatagc tgcaaatgga
     2281 gcccagctct ttggatatac gatatcagca tctttgaaag cttcagccat atcgtttgtt
     2341 tttgtgaagg atccgccgtt tttctcagca ttctttttgg caatctcttc aacttccggc
     2401 attacatcat atccttccgg atgagcaaga acaacatcca tgccgaaacg tgtcatcaga
     2461 ccgataacgc cctgcggaac ggagagtggt ttaccatagg atggagagta agcccatgtc
     2521 atagcgatct ttttgccttt cagattctca acaccgccga attcatggat gatgtggagc
     2581 atatctgcca tacactgtgt cggatggtca acgtcgcact gaaggtttac aagagtaggt
     2641 ctctgctcaa ggataccgtc tttgtttcct tctgtaacag cttccatgaa ttctttctgg
     2701 taagcatgtc cttttccgat gtacatatca tcacggatac cgatcacatc agccatgaaa
     2761 gacaccatgt ttgctgtttc acgaacagtt tcaccatgag cgatctgaga tttcttttca
     2821 tcaagatcct gtacttccag accaagaagg ttacatgcgg aagcaaaaga gaaacgtgta
     2881 cgtgtggagt tatcgcggaa gatagagatt ccaagaccac tctcgaatac ttttgtggag
     2941 atattgttct ctctcatgaa acggagagca tcagcaactg tgaaaacggc ttccagttca
     3001 tcatctgttt tgtcccatgt ccagaagaaa tcgttgttgt acatttcttt gaagtttaag
     3061 ctgtttaatt tatcaatgta atcctgtaat gttttcataa aatcaatacc tgctatgctt
     3121 tgatagctta tcctttcctg atatgaaata attgaatttc tgcgtttggc agaacaccgg
     3181 ttatccggct gtatctgttt atcttgtgtc cctgcctgtt acagcaggga ttctgtccgg
     3241 acacatatta agcctttagg atgataggaa atccgtcgcc taaaaaaatt gaaaatttat
     3301 ttattatttg cagtatgcag ttggaagagc agcgtataca gcagcgcatc ttacaaggtc
     3361 gatcttccat gttttttcgt tcggagcatg agcctgtgct tctgcaccag gtccgaatcc
     3421 gatacaagga atgctgttac gtcccatgat tgttacaccg ttagtagaga atgtccattt
     3481 gtctgtaagc ggacgagctt ttctcatgcc ttctgtctca gcatttccga gacgctcttc
     3541 gccgtacagt cctttatatg cttcttccag agcctgtgtt actttgtgat ctttcgggat
     3601 tacccatgtc gggaagtagc actcgatcgg atatacaagg tctgtatagg acggacggtt
     3661 gtattcatac atggatactg ttacgtcgtc gccatatttc tgtacagccg gaagagcacg
     3721 gatctcatcc aggcagcttt cccatgtttc gcctgctgtc atacgacggt caagagatac
     3781 agagcaggag tcagctactg cacagcggct tggggatgtg aagaagattt cggaagtagt
     3841 aacagtacca cgtccaagga aacgtgcttc ttcccattca gggttgtatt tctcatcaag
     3901 catttttaca agacctttga tctctgtggt atcagcagca tcgttttcgt ttaatgcgcg
     3961 gatatcctgg agaatatcag ccattttgta gattgcattg tcaccacgtt ccggagcgga
     4021 accatggcag gaaacaccct ttacatctac gcggatttcc atacgtccac gctgtcccct
     4081 gtagataccg ccgtctgttg gttctgtgga aacaacgaat tcaggacgaa caccatcttc
     4141 atggatgatg tactgccagc agagaccgtc acagtcttct tcctgtacag tacctgtcac
     4201 aagtacctga tatttatcgt ttaaaagacc aaggtctttc atgatcttag caccgtatac
     4261 tgcagaaaca ataccgccca tctggtcaga tgttccacgt ccgccgattt cttcatcaga
     4321 ttcgaaacct tcgtatggat caaattccca gttcttgata ttaccgatac cgactgtatc
     4381 aatatgagcg tcaaaaccaa tgagagtttt acctgttccc atgtagccga ggatattgcc
     4441 catcggatca atctgaactt tgtcgaatcc gactttttcc atttcctctt tgattctcat
     4501 gatatgtcct ttttctccgc agctttcgcc aggaatgcga accagatcgc gaaggaactt
     4561 agtcatatca tccttataac ccattgcagc ttcgttaatt tttgcgtaat ccattttttt
     4621 accctcccaa tatgtataaa atattatgat gttagggtca aaaggtattt tgcccctaat
     4681 ctgatatcat attattagtt actggtatat cattttcgag ataaccatac tacttacctg
     4741 tctgtgttca ccaaaaacat catttgctta aagattcgtt tgttccgtat aatccgtccc
     4801 atacgatctc gcggtagcga acaggatcag tgtcaccttc tgtggaaata acaagtacta
     4861 cggaattctc atccagtttc agcgcttctt ttaagtcttt tgcatcttca tcgtgaagag
     4921 cagtgaagca gaaaccaagc ggaacggaac cggattcacc ggagacaacg tgtggatcat
     4981 ctcccagtgg attagcgtag atacgtgttg cctttgcgct catccagtca ggacaggatg
     5041 caaatacatc tacgtgattt ttcaggatat cccatccgat cgtatttccc tcaccgcatg
     5101 caagaccggc cataattgtc tgaagatcac ctgtaacatt taccagattt cctgtctttg
     5161 caacagcgga gcggtacagg cagtcagcag cacttgcttc acagacagcc ataaccggcg
     5221 ggttatcttt atatttatga gcgaaataac cgactacggc acctgctaaa gaaccaacac
     5281 cggcctgaac aaatacatgt gtcggacgtt caacacccat ttcttttaac tgctggtcag
     5341 cctcaagaac cagtgttccg tatccctgca tgatccagga tggaatttct tcatatccgt
     5401 cccatgcggt atcctgaacg atgataccat gttctgtttt ggcagcttct gctgcagcca
     5461 ttcttacgca gtcatcatag tttacttctt cgatcgtaac agtagcacct tctttggcaa
     5521 tgttatcgaa acgagtcttt gttgttccct taggcattct tacaactgct ttctgtccaa
     5581 ggcgcttagc tgcccatgca actccacgtc catgattacc gtctgttgca gtaaagaatg
     5641 tagcctgtcc gaattcttct cttaatttat cagaagagag aacattgtat ggcagctcgc
     5701 tgatatcacg tccaagttct tttgcgatat agcggcccat tgcataagaa cctccaagta
     5761 ctttgaaagc atttaagcca aagcgatagg attcatcctt acagaaaata ttttttactc
     5821 ctaaatattt cgcaagggat gaaaggttct gaagaggcgt cacactgtac tgtgggaaac
     5881 ttctgtggaa ctcatttgct ttctttacat tttcttcgga catcagttcc aggtgtttat
     5941 catctgattt cggaacctcg tttacagtcc attttaatcc ttctgtcata aaatgacctc
     6001 ccttaaaaat tatcatttgg tttccttaac ttgtgattct atcataccat atattttaaa
     6061 aattgcaata gaaaaataca aaaattttta ggtttttcaa aaaaaaatta ggtttcataa
     6121 tttgtacatt gatataagga tttggatatg ataaaataat gagtaatgtt cgttttattt
     6181 ttacaggata gacagtaaag tgggtataaa agagcaataa aaaagataca gaagaggaga
     6241 aaatattatg gcagtatttc atgcattccg ggcacttcga cctacaccgg aaaaggctgc
     6301 tgatgtggca gcacttccat atgatgtggt aaaccgggaa gaagcaaaat caatcggaga
     6361 tgagaatccc ctgtcctttc ttcatattga cagaccggaa atggatctgg aacctgagac
     6421 agatctgtat gatgatcggg tttatgaaaa agcaaaagaa aatcttgaca atatggaaga
     6481 aaagggaatt cttgttcagg atcagaaggc ctgttactat atatatgaac ttgtaagaaa
     6541 aggaaagaca cagaccggta tcgtaggatg cagttccatt gatgattata tgaatggtgt
     6601 agtgaagaaa catgagctta ccagagaaga taaggaacag gacaggatcc accatgtaga
     6661 ttcctgtaat gcaaataccg gtcctatttt tctggcatgc agatatccgg attttctgct
     6721 tacactgatg aataactgga aagatcatca tgaagcagca tatgatttta cagaagagga
     6781 tcagatcaca cacagagtat gggtgattga tgaagatgag gtcatttctg aaataaataa
     6841 ggaatttgca gggattgatt ttctgtacat cgcagatgga catcaccgcg cagcttccgc
     6901 tgtaaaagta ggtttaaaga gaagagaaca gaatccggga tatacagggg aggaagagtt
     6961 taattatttc ctgtctgttg tatttcccta tgaccagctc tgcattcttc cttataacag
     7021 gattgtaaaa gatttgaacg gcctgactgt aaaggcattt ctgggcgccc tgaagttcaa
     7081 ctttgaactg atgctgatgc cgggatttcc atgcaagcct gtagagaagc attgtatggg
     7141 aatgtatgtg gacggacagt ggtatcacct gaaagcatgg ccggatatct atgagaagaa
     7201 ggacgtggtc ggacagctgg atgtatccat tcttcaggaa aaagtcctca gaccagtcct
     7261 gggaatcgaa gatccgcgca cagaccagag aatctccttt gtgggcggaa gccataaggc
     7321 agcagagctg gcagagattg cggacagaac cggcggtgta gcctttgtca tgtacccgac
     7381 atctatggaa gacctgatga agattgcaga cgagaacaaa ttaatgcctc caaaatccac
     7441 ctggtttgag ccaaagcttc ggagtgggct gtttatacat aagttataat ttgccgaaga
     7501 tgttactgtt cactccgttc acagtaacgt agccaaaatt cattccagat tgcctgtggc
     7561 aatggaattt tggctcgtat gtctcgggat tttggcatat tcatgccaaa acacctcgcg
     7621 gaatagtggt gtgtgaacag taacccgaag atgtcttata aaaatattat aataatttcg
     7681 ctgtagactt tttcttcctt caatggtaca attggttcta tacaaaagag aacgagacgt
     7741 actataacga aaggagggaa gaatgtggaa gatgcggaat tgagaaatat ccttttttct
     7801 atacagggaa gcattgccgg ttttcaaaat gatatgtccg atgtaaagaa cgatatcgca
     7861 gatatgaaga cagatattgc aaacatgaag acggatatca cgaacatgaa ggcagatatc
     7921 acgaacatga aatcagatat tgtgcaactc aagggaagcg taaaaactat agaacttaaa
     7981 ctggaaaatg aaattgacag aaaaatatct gccctatttg atgcacgtat ggatgagctt
     8041 cgctatagaa aggagaataa ggaaactcga gagaaagttt ttgaactgga tatgcgtgta
     8101 gacaatttgg aaaaagccat catgccagcg taactgtaac agatgattgt aaggcttgta
     8161 cataggataa acaggaagaa attttataac ataaaaagta catgaaattt cttcctgcta
     8221 aatttgtata atttttgtaa atttttcaaa aaacagttga aatcacagaa ataatttgtt
     8281 atactaactt gcgttacggg gtatggcgta gcttggtagc gcgcacggct gggggccgtg
     8341 aggtcgcagg ttcaaatcct gttgccccga ctgacatatg gttaaatcgt ttgcagtata
     8401 tttgcaaaga atgattcaga cgtatgttca tttcaaaaaa gccaaataaa gttataagta
     8461 aaatgcaatg ataaggaata gtacacccgg accggagcac agagaactgc tggttgctga
     8521 gaagcagtgg aaggaaattg tggaactcgc ctttgagcag ctgcctgaaa tcatacaaga
     8581 gtaggtgcag acggtttcca ccgttatatg gagaggatat aagaataccg gatatccgga
     8641 gattccgtat cccatgagtg tatgacattg ttcataaata agagtggtac cgcgtaagat
     8701 gataatatct ttcgtctctt gcagataagt ctgtggagat ggaagatttt tttatgtctt
     8761 tttacagtca atccccacag tccaaacata atatttacat aacggaggaa gaaaaaatga
     8821 tgaatccaag caaatatcag agacagtatt ttatgccgcc tgttaaatgc atgaaatggg
     8881 cagaaaaaga atatgtggac aaagcacctg tctggtgttc tgtagacctt cgtgacggta
     8941 atcaggcact ggtgattccg atgagtctgg aacagaaaat tgaattcttt aaacttcttg
     9001 taaaaatcgg ttttaaagaa attgaagtag gtttcccggc tgcttctgaa acagaatatg
     9061 aatttctgcg taccctgatc gagcagaatc tgatcccaca ggatgtaact attcaggttc
     9121 tgactcaggc cagagagcat atcatccgca aaacttttga agctgtcaaa ggcgcaccga
     9181 aggcaattgt acatgtgtac aattccacct ctgtagctca gagagaacag gtatttaaga
     9241 aatccaaaga agaaatctta aagattgcag tggatggtgc cgcattatta aagaaactgg
     9301 ctgatgaaac agaaggaaat ttccagtttg agtacagccc tgaaagcttt acaggcacag
     9361 aaccggaata cgctctggaa gtatgcaatg cagttcttga tgtatggcag cctacagcag
     9421 ataacaaatg catcatcaat ctgcctgtaa ctgtacagca ttccatgccg catgtatatg
     9481 caagccaggt agaatatatg tgtgaaaatc tgaaataccg cgagaatgta atcgtatctc
     9541 tccatccgca caatgacaga ggatgcggtg ttgcagattc tgaaatggga ttacttgcag
     9601 gtgcagacag aatcgagggt actctgttcg gaaacggtga gcgtaccgga aatgtagata
     9661 ttgttacact tggcatgaat atgtattccc agggtgtaaa tccaaaactt gacttctctg
     9721 atatgccgca tatctgtgaa atatatgaag aatgtaccgg aatgaaagta ggcgaaagaa
     9781 gtccgtacag tggtgcactt gtatttgccg cattttccgg ctctcatcag gatgcaattg
     9841 ccaagggtat gcactggaga gatgacaagg acccggatca ctggaatgtt ccgtatcttc
     9901 cgatcgatcc gacagatgtg ggaagaaatt atgacgcaga tgttatccgc atcaacagcc
     9961 agtctggtaa aggtggcgtg ggatatatcc ttgagaccaa attcggtctt aaccttcctc
    10021 cgaaaatgcg tgaggcaatg ggatatgcca caaaagctgt ttcagaccac aaacataaag
    10081 aacttcatcc tgacgaaatt ttcaatctgt ttaaacagac ctttgagaat atcacagaac
    10141 cgtacagtat caatgaagta catttccagc agaaagatgg tggtattgta acaaaagtta
    10201 cctctacttt ccgcggaaag acaatcacta cagaggcatc cggtaacgga cgtcttgatg
    10261 cagtcagcaa tgcattgaag aaggcatatg agctgaaata ttccctggaa acatatcagg
    10321 agcatgcgct ggagcgcagt tcaagttcca aagctattgc ttatgtcggt atcaaaaagc
    10381 cggatggaac ccttgcctgg ggtgcaggcg tagacgcgga tatcattcgc gcatctattg
    10441 atgcacttgt aacagcgatc aataaccgtt agattgttcc gacacgcccg attttttcct
    10501 gctgtttttt gacttctgca ggtcagacta atatccgctt ggcagggaat aatatagttt
    10561 acataaaata tcaaaaatca gataccggtc agattgtcca gaggacttcc tgaccggtat
    10621 tttttttgta tttataaaaa tacaagaaag tcttaatgta cgcgataaag tacaataaag
    10681 aagcaaactc cgatgaaaag ctatcagaat tgtatttaat taaaatcata aaggaaatta
    10741 attgacataa cactcatgtt tacgtatact gactgcatgg gcagaaaagt gtcctaaata
    10801 agtacaattt acattttatt atctcactcc agactagtga gagatgcgcg gaaatatttt
    10861 agagaaagag gtaaaagaat gaaaaatttc gaacagtgga atggctttaa gggcaaccgt
    10921 tggaaagaaa aaatcgatgt acgtaacttt attggaatga actatacacc atatgacggt
    10981 gatgcttctt tcctggaagg acctacagaa gctacaaaca aactgtgggg caagctccag
    11041 gcacttcaga aagaagaacg tgccaaaggc ggagttcttg atatggagac agaggtagtt
    11101 acatctctga cagcatatgg tcccggatat attgatgaag aaacaaaaga ccttgaaaaa
    11161 gttgttggtc ttcagacaga taaacctctg aaacgtgctt tcatgccata cggcggtatc
    11221 aaaatggcag agcaggcttg tgaaacttac ggatataaag taagtgacaa gatcaaagat
    11281 gttttccaca actatgaatt taaaactcac aaccagggtg tatttgatat ctacacacct
    11341 gagatgaaag tagcacgtca caacaagatc cttacaggtc ttccggatac ttacggacgt
    11401 ggacgtatcg ttggcgacta cagacgtgtg gctctgtacg gaattgacgc tctgatcgaa
    11461 ggaaaacaga aagacttcgc agcatgcgac cgtcagggta tgagacgtta tgacttccag
    11521 cttcgtgaag agatcgctga tcagatccgt gctctgaaag gcatgaaagt tatggctgaa
    11581 tcttatggat atgatatctc caaaccggcc aaagatgcaa gagaagcttt ccagtggctg
    11641 tacttcggat atcttgcagc catcaaaact cagaacggtg ctgcaatgag tgtcggacgt
    11701 atttccacat tccttgatat ttatattgaa agagatcttc agaacggaac tcttacagag
    11761 aaagaagctc aggagcttgt tgaccacatg gtaatgaaat tccgtatggt taaatttgca
    11821 cgtatccctt cttacaacca gttattctcc ggtgacccgg tatgggcaac tctggaagta
    11881 gcaggtatgg gacaggacgg acgttccatg gtaacaaaga acgactatcg tttcctgcac
    11941 acactggaag atatgggacc ggctccggaa ccaaacctta cagtacttta ttcttcaaga
    12001 ctgcctgaga acttcaagaa atatgctgca aatatttctg ttacaacaag ttctgttcag
    12061 tatgagaatg atga
//
