LOCUS       gnlProkkaNJKIFNDI_152  13685 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NJKIFNDI_152.
ACCESSION   gnlProkkaNJKIFNDI_152
VERSION     gnlProkkaNJKIFNDI_152
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:02:42
            Original ID  :: gnl|Prokka|NJKIFNDI_152
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13685
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13685
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2096:3685]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2097..3685
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13685
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13685
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             3..89
                     /locus_tag="ctg152_1"
                     /transl_table=11
                     /translation="MIQICNIIVLRKKRTDIWLKVKNDYQET"
     CDS             118..1623
                     /locus_tag="ctg152_2"
                     /transl_table=11
                     /translation="MSNNIRIRKNKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDGDNVDKTEGSGKTDPTENADPTETPEISSE
                     KPAADENADTDNKEDKESKSDQDNKTDTGNEENKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGAGDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSVNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVAVFIKKRKK"
     CDS             1673..2023
                     /locus_tag="ctg152_3"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSVMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             2097..2237
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg152_4"
                     /sec_met_domain="TIGR03973 (E-value: 9.4e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.2e-27, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             2318..3685
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg152_5"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 4.6e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.1e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.7e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.9e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             3797..6205
                     /locus_tag="ctg152_6"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSERETLQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVFALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             6287..7999
                     /locus_tag="ctg152_7"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYITALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DSQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             8147..8671
                     /locus_tag="ctg152_8"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             8709..11039
                     /locus_tag="ctg152_9"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPEVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLLEKIRQVESVIDVERTTG"
     CDS             11104..11733
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163; E-value: 1e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg152_10"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACHQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             11726..13240
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg152_11"
                     /sec_met_domain="PF04055 (E-value: 1.6e-24, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFENRDFEHDVYELIKAFYPEAEIHTLYENAEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 ataatataca gatatgtaat attattgtat tacgtaaaaa gagaactgat atttggctga
       61 aagtaaaaaa tgattatcag gaaacataag aatcgaatat aaatatagag gtgcgatatg
      121 tccaataata taagaataag aaaaaataaa ttaaaaggaa cgggtatttt tgcggcagcg
      181 gctttaacag cggctttgat tgcaggaaat aatataccgg gtgtaacaag acaggtcagt
      241 gcggctgagt cacaggagaa tactgtgtct tctctgatcc cggacaacat tacgcttgat
      301 aagcctgtag aacttgcgga tgtagaactt ccggcaacgg aatatggaac ttttgaatgg
      361 gcagatggaa gtttcgttcc tgcacagcgt gtacagagct gtgaggtact tcttataccg
      421 gcagaagggc aggatttaag ccatgtggat ggatgggatc cggagagcgg cgcggttgtc
      481 ggttacatca atgtaatagt gaacagtatt acggatggtg ataatgttga taagacagaa
      541 ggctcaggta aaacagatcc aacagaaaat gcagatccaa cagaaacgcc tgaaatttcg
      601 tcagaaaaac ctgccgcaga tgaaaacgct gatacagaca ataaagaaga taaggaaagt
      661 aaatcagatc aggataataa aactgataca ggcaatgaag agaataagat tgaagaagat
      721 aaaacagata ataaaaacaa caaagataat aacagcaatg cagataagac ggataaagat
      781 acagaaacta ccggtaagct ggaacctgca gatgatatga cacaggataa agaagatacg
      841 aagaaagatg atgaagatgg cgcaggtgat aatatctttg ataatcctgt tctgccggac
      901 gataaggatg accgtcctac agatgcagag gattctcttt ctgatgaaga aaaagaagag
      961 agggccgcac ttaatcatac ctgcgacggt attacagtaa gcggagttaa tcttccatgg
     1021 tatgtacagt tcagagtttc aagcggtgac agctatcagt ttaccaatga atcagatgca
     1081 atgattttcc agtcttatga atttgaactc tgggatctta agaataatac agaatacgag
     1141 atccctaatg gagattatat cagtgtcact gtgccggtaa aatccggata tcagtatact
     1201 atcgaacatc tcctggataa cggggcaact gagacgatta ttccgagtgt agagaatggt
     1261 attatggtat tcagcacaca ttctttcagt ccatttggaa ttgcaggaag cagacaatta
     1321 gtaggacctg atgcagggaa tgatacggac gacacagatg cggtaactcc tgcaccggct
     1381 tcctccgaca gtcagagctc tgattccgga aagaacaata cagtatctgt gaatgacagt
     1441 tctgacagca ataatggttc ttcttctgat cagaatgata attcaacgga aaataaagct
     1501 gtgaaaaata acaatacagt aaataccgga gatacaacat caattatgcc gtttgtgata
     1561 ctgtttgtgg cagctgcagt gatcgccggt gtggctgtat ttataaaaaa gagaaagaaa
     1621 taaaagaata acactgattc ctcccccata tagtttaaca ggaggggaag caatgaaagt
     1681 cagagcaatt ttgaaatcac tattatttgc atatgcatta acaggagtgg cattactgct
     1741 tttggccctg gtactgtttg cttttgatct gggagaaaca gctgtagatg cgggtattat
     1801 tataatttat gtacttgcat gtttcatggg aggctttatg gccggcaaaa ttgtgcgtaa
     1861 agacaaatat ctgtggggtg ttatcacagg tctggcttac tatgtattac tgttgactgt
     1921 ctctgttatg gcaaaaggcg gctgggatat gagtgcagct catgcagtta caacattttt
     1981 tatgtgcaca ggcggcggaa cactgggtgg aatgctgtcg taaaaaaaag cttttaaaat
     2041 gaaaagatat atgatatact atgccaagaa tataattaca taaggaggat agagttatgg
     2101 aacatatcaa aaccctgaat acaaagaatt tacagaacac tgtaaaaaaa ggtggatgtg
     2161 gcgagtgcca gacttcctgc cagtccgcat gtaaaacttc ctgtacagta ggaaaccaga
     2221 gctgcgagca gaaataagat cagctatgga gaaatgagat aagcagcgga acttttattc
     2281 cgctgcttat cttacgctta gaaaggattt tagtaaaatg agtctgattc accgttataa
     2341 aagcaatggc tttaatattg tactggatat caacagtgga tgcatccatc tggtagatga
     2401 ggttacatat gaggttcttc catatctgga agagggcctt ggcacagaag ctattgcaga
     2461 gaaactggaa aacaaatata acagagaaga tattgagaca tctgtaagag aatgtaataa
     2521 gctgaaagaa gatggaatgc tttttacaaa agatgtttat gagaatgtaa ttgaagaatt
     2581 ttcaaataac cggcagaccg ttgtaaaagc attgtgcctg cacattgctc atgactgcaa
     2641 tctggcctgc cgttattgtt ttgccgaaga aggcgaatat catggcagaa gagctcttat
     2701 gtcctatgaa gtcggcaaaa aagctcttga tttcctgatc gcgaactccg gttccaggaa
     2761 aaacctggaa gtagatttct ttggcggcga gccgctgatg aactggcagg ttgtaaaaga
     2821 tctggtaaaa tatggcagag agcaggaaaa gcttcacaat aagaaattcc gtttcacttt
     2881 aacgacaaac ggagttcttc tgaatgatga agtaatggaa ttctgcaata aagagatggg
     2941 caacgttgta ctgagtgtgg acggacgtaa ggaagtacat gattacatgc gtccattcag
     3001 aaaaggtgca ggaagctatg acctgatcat gccgaagttc cagaagtttg cagaatccag
     3061 aaatcaggac aagtattatg taagaggtac ttttacccac cataatcttg atttctccaa
     3121 ggatgtgctt catctggcag atcttggatt caaacagatt tctgtagagc ctgtagttgc
     3181 ggctgatacg gaggaatatg caatccgcga ggaggatatc ccccagatca tggaagagta
     3241 tgatactctt gcaaaagaaa tgattaaaag agagaaagag ggaaaaggat ttaacttctt
     3301 ccattttatg atcgacctta caggtggccc ttgtgtatac aagagactgt caggctgcgg
     3361 ttcaggaaca gagtacctgg ctgtaacacc ctggggtgat ttttacccat gtcaccagtt
     3421 tgttggtgaa gaacagtatc tcatgggaaa tgtagacgaa ggcatcacaa agccggaaat
     3481 ccagaaggaa ttcggcggat gcaacgttta cacaaagaaa gactgcaaag actgcttcgc
     3541 acgtttctac tgtagtggcg gatgtgcggc aaatgcattc catttccagg gagatatcaa
     3601 aggcaattat gaaatcggat gcgaactcca gagaaaacgt gtggagtgcg ccatcatgat
     3661 aaaagccgca ctggcatgtg attagtgggc agtaatctgt ctgactgata ccgccgtcgg
     3721 ctgttatcat aacagaaaat ggctggcagg cggatgaaca tgaccgcgga caaaaaatca
     3781 agaagggaaa agaactatga agaaaagtaa aggaatcgta gtgctgcttc tgacactgat
     3841 cctgactgtg ttcttttgct ttactgcagc cgtaggtatc ggtcctaccg gaaccggtgc
     3901 agcaaaacat atcaacacgg gtcttgatct tgccggtggt gtcagcatta cctaccaggc
     3961 taaggaaagc aatccgacaa gcgaagagat gtcagatacg atctacaagc ttcagaagcg
     4021 tgtagagcag tacagtactg aggctcaggt ataccaggaa ggatcagacc gtattacagt
     4081 tgaaattcct ggtgttacag atgcagatac tattctgaat gatctgggta aaccaggttc
     4141 cctgtatttc atcacaaaag aagatgctga cggaaaccag aactttacta caggacagga
     4201 tggatatgtt ctttccagaa ctatggatga gatcaaggaa tccggaagtg ttgttctgga
     4261 aggttctgat gtagcagatg cccagggtgg tgcgatccag aatcagaaca caagtgcaaa
     4321 ggaatatgtg gtaagtctta ctcttacttc tgatggagaa aacagtggta aaacaaaatt
     4381 tgcagaagct acaaagaata atgtaggcaa gcagatcgct atcgtctatg acaataacat
     4441 tatcagtgct ccgaatgtaa atgaagagat ttccggcgga aaagcacaga tcagcggaat
     4501 gtctgacctg gaagaagcac agaaccttgc ttcttatatc cgtatcggtt ctctgggact
     4561 ggaactggaa gaacttcgtt ccagtgttgt agctgcacag cttggtgaag aagcaatctc
     4621 tacaagtgtt cttgcaggtg caatcggtct gatcatcgtt attatcttta tgatcattgc
     4681 ataccgcgta cctggtgtag ttgcaggtat cgcactgatt ctttatacat cattaatgct
     4741 gatcacgctg aatgcctttg atattactct tactcttccg ggtattgcgg gtattattct
     4801 tggtatcggt atggcggtgg atgccaatgt tattatttat gcccgaatca gagaggaaat
     4861 tggtgcagga gtttcagtaa ggaattctat taagtccggt ttcagcaaag ctttctctgc
     4921 aatctttgat ggaaatatta caacactgat cgcagccttt gtgctgatgt ggcttggttc
     4981 aggtactgtt aagggatttg cttatacact tgcccttggt atcgtgatct ccatgtttac
     5041 agcactggtt gtatccagac tgattgtaaa tgcactttat gcagttggtg tacgtgatcc
     5101 gaaattctac ggatctgcaa aagaacgtaa ggcagttgat ttccttggaa agaagaaagt
     5161 attttttgct atttccatta tcctgatcct ctgcggtccg gcagcgatgt ttgctaattc
     5221 gcatgcagga aacaaagcgt taaattacag ccttgagttc tcaggcggta cttctacgac
     5281 tgttacattt aatgaagata tggatattaa gaccattgat tctgaagtaa ctcctgttgt
     5341 agaagaggtg acaggagata aaaatgttca gcctacaaag gtagtcggaa caaatcaggt
     5401 tgtgatcaag acacgttctc tgaatcagag cgaacgtgaa actctgcaga gtgcactggt
     5461 tgagaaattt ggtgtagatg acagcacgat ttccacagaa agtatttctt ctacagtaag
     5521 tagtgaaatg cgtcgtgatg cgatcgtagc cgttatagta gctacaatct gtatgcttct
     5581 ttatatctgg ttcagattta aagacatccg ttttgcaagc agtgcggtat ttgcgcttct
     5641 gcatgatgtt ctggttgtac ttgcattcta tgctattgcc agagtatctg tcggtaatac
     5701 atttattgcc tgcatgctta caatcgtagg ttattctatc aatgctacaa tcgttatttt
     5761 tgaccgtata cgtgagaacc ttcacagtgg ttccagagaa aaactggcag aaattgtaaa
     5821 cacaagtatc actcagactc ttacaagaag tatttatacc tcttttacaa cttttgttat
     5881 ggtagctgtt ctttatatca tgggtgtttc ttctatccgt gaatttgcag cacctctgat
     5941 ggttggtgtt cttgtcggtg catattcttc tgtatgtatt acaggtgcgt tgtggtatgt
     6001 gatgaaaaag aaatttgcag gaaaaggaca gccggcaatt gctgcagctt ccgcatctgc
     6061 aaagtcctct tcaaagccga agaaagcacg tgatgtatca cagaaagatc cgactcagcc
     6121 aaagaagaaa aacagaaaaa gagtagctga acgtctggct gccgaagaag cagctaaaaa
     6181 acagcagaat gatgatgctg aataaaacaa taattgtctg aaaaacaggc agacagaaat
     6241 atcccggggt aaaactccgg gatatttcta tgaggagaga aaatatatgg agaaatgggt
     6301 aatagcagca aaaagagcag attttaacca gatcggtcaa cagtttcata ttgatccggt
     6361 gattgcgaga ctgatcagga acagagatgt gatcggagaa gataagataa gagagtatct
     6421 gtcaggaaca gtacaagagc ttccttctcc ctggctgatg aaggatatgg aaaaagctgt
     6481 agatatcctg gagaaaaaaa tatcgcagaa agcaaaagtc cgtattattg gtgattatga
     6541 tattgatggt gtgacctcta catacatttt aatgaaaggc cttgcgagga tcggagcaga
     6601 tgtggatact tatattccgg acagagttgc agacggatat gggattcatg cacatcttat
     6661 agaaagagcg gaaacggacc ggatcgatac gatcgtgacc tgtgataatg gaattgctgc
     6721 ggctgctgaa atccagatgg caaaggataa gggaatgaca gtgattatta cagatcatca
     6781 tgaggttcct tacagggagg aaaagggaga acgccagatg gtgcttcctc cggcagatgc
     6841 gattttgaat ccgaaacaat atgattgtcc atacccgaat aaaaacctgt gtggagcagt
     6901 ggtggccttt aaatatatta cagcacttta cgagagattt ggtgttccgg cagaggagct
     6961 ggaagattat tatgaactgg cggctattgc aacagtagga gatgttatgg atcttcaggg
     7021 agagaacagg attctggtaa aagaagggct gtgccgtctg aaaaatacca aaaatcaagg
     7081 attgcaggaa ctgatccgcg caaattctct ggaagatgct aaaatcacag cttatcatat
     7141 cggatttgtg ctgggaccat gtatcaatgc cagtggcaga ctggatacag ctgcccgttc
     7201 tcttgcactt ctcaatgcaa aaacaaagga agaagcagca aggcttgccg gagatcttac
     7261 agctcttaat cagagccgaa aagctctcac tgagaaagga aaagaagagg caatccggat
     7321 catagagact acagagctga aaaatgacag agtactggta gtttatcttc cggattgtca
     7381 tgaaagtctt gccggtatta tagcaggcag gatcagggaa aaatatcaca ggcctgcctt
     7441 tgtattgacg ggcggtgaga caagtgcaaa aggaagcgga agatcaatag aaagttactc
     7501 tatgtatgaa gaactggtaa aatgtgcaga cctgatgata cagtttggag gtcatccgat
     7561 ggcagcaggt ctttctatag aagaaaaaaa tatagaagaa ttccggagac gtctcaatgt
     7621 aaattgtacg ttgacggacg aagaattgcg tcctaagatc gtgattgatg tgccgatgcc
     7681 tgtgtcttat attacaaaag aactggtaga acagatttcg cttttggagc cctttgggaa
     7741 agggaataca aaaccggtct ttgcgcagaa aaatctcaga gtgcttgatc acagtattat
     7801 cgggaaaaat aaaaatgtag taaaattaaa acttctcgat tcgcagggga tttcagtgga
     7861 aggcatttat ttcggagaag cagaggattt tgtgaacttt atcagggaaa aagacagtat
     7921 ttctgttact tattatccgg agatcaacag attcagggga cgagagagtc ttcagatcat
     7981 tattcagaat tactgttaat attaccgcct gttttgtaac cgccggtaag cctggaaata
     8041 caaatgtcag ggcttaacag taacttgatt ctgaaataaa aaggtgatat actataaaat
     8101 atttatgagc gaacagcaat ataacacaca ctggaggaga aataaaatga agaaaattga
     8161 agattatgta ttaagtatac cggattttcc tgaaccgggg attattttca gagatattac
     8221 aagtgttctg caggatgcgg atggcctgca gctggcaatc gactccatgc aggactgcct
     8281 taaggatata gatgtggacg tgattgcagg aacagagtcc agaggcttta tttttggtgt
     8341 accgatcgca tataatcttc ataaaccatt tgtaccgatt cgtaaaaaag gcaaacttcc
     8401 ccgcgaaaca gtatctgtaa gctatgattt ggaatatggc agtgcagaga ttgaaatgca
     8461 taaagattcc ataaaaccag gtcagaaagt ggttatcgtt gatgatctga tcgcaacagg
     8521 cggtacgatc gaagcagcga tcaagctggt ggaacagctt ggcggtgagg ttgtcaaggt
     8581 tgtatttctc atggaacttg caggtttaaa gggacgcgaa agactgaatg ggtatgatgt
     8641 agcgtccgta atttgttatg atggtaaata agcacagctg attgtgcagg acaggcaggt
     8701 gggagcatat gacagagata acaaaaagta cagaagcaaa aaaagatgaa atgcaggttg
     8761 aaaaagagaa gctggaatct gtaaagagag cagatgcggc agtaaagacc atgcatgatt
     8821 ttacaagtcc ggaggtgctt tataaagaac tgataaacag tgttctgaag tatcatccat
     8881 caacagatat ttccatgata gagaaggcat ataaggttgc aagtgaagct catgaaggac
     8941 agaagagaaa gtctggagag ccatatatca ttcatccttt gtgtgttgcc atcattctgg
     9001 cagatctgga acttgacaaa gaaacgatag ttgcaggtct tcttcatgat gcagttgaag
     9061 atacctggat gacctatgag gaagtggaga aggaatttgg ttcagaggtt gcacttcttg
     9121 tggatggtgt taccaagctg ggacagttat cttattctgc ggataaagta gaagttcagg
     9181 cagagaacct cagaaagatg tttcttgcca tggctaagga tatcagagtt attctgatca
     9241 agcttgcaga ccgtcttcat aatatgcgta ccttacagta tatgcgtcct gaaaagcagc
     9301 aggaaaaggc cagagagacc atggatattt atgctcctat tgccatgcgt ctgggtattt
     9361 ccaagataaa ggtagagctg gatgacctgt cgctgaaata ccttaagccg gaggtatatt
     9421 atgacctggt gcataaggtt gccctgcgta aaagcgagag agaacagttt gtaggtgcga
     9481 tcgtaaaaga agttaagaag catatggatg atgccaatat taaggcacag gtggacggac
     9541 gtgtaaaaca ctttttcagc atctacaaga agatggtaaa tcaggataag actattgatc
     9601 agatttatga tttatttgct gtccgtattc ttgtagatac agtgaaggat tgttatgctg
     9661 cccttggtgt aatccatgag atgtataagc caattccggg acggtttaaa gattatattg
     9721 ccatgccgaa acccaatatg tatcagtcat tgcataccac attgatcgga cccaacggac
     9781 agccctttga aatccagatc cgtacttatg aaatgcacag aactgcagaa tatggtatcg
     9841 ctgcacactg gaaatataag gagtcgtctg acggaaaagc tcctgtaggt aagagtgagg
     9901 aagagaaact gaactggctg cgtcagattc tggaatggca gagagacatg tctgataaca
     9961 aagaattcat gagtcttctg aagaatgacc tggatctttt tgcggacagt gtttactgtt
    10021 tcactccaca gggagatgtt aaaacacttc caagcggttc tacaccggtg gattttgcgt
    10081 acagtgttca cagtgcagtc ggaaataaga tggtaggtgc cagagttaac ggtaagctgg
    10141 ttccgattga atatgagatc aaaaacggcg accgtattga aatcattact tcacagaatt
    10201 ctcagggacc aagccgcgac tggctgaaac tggttaagag tactcaggca aagaacaaga
    10261 ttaaccagtg gttcaagaag gaattaaaag aagataatat ccttaagggc aaggagatgc
    10321 ttgcgcagta tgcgcgtgca aagggattta agatcgcaaa ttatacaaaa acccagtatc
    10381 tggaggctgt tttgcgtaaa tatggtttca gggactggga ttcagtactt gctgcaattg
    10441 gtcatggcgg attgaaagaa ggtcaggttt tcaataagct ggtggaggca tatgataagg
    10501 aaaataagaa gaatctgaca gacgagcagg ttcttgaggc tgcttctgag acacaggaaa
    10561 agcttcacat tgccaagagt aagagcggca ttgtggtaaa aggaatccat gatgtggcag
    10621 tccgtttttc caagtgctgt aatccaatcc cgggtgatga gattgtaggt tttgttacaa
    10681 gaggacgtgg aatcacaatt catcgtacag attgtgtcaa tgtgctgaat atgtctgaga
    10741 cagacaggac acgactgatt gaggcagagt ggcagcagcc tgataccaag gaaaaagaga
    10801 agtatatggc tgagattcag gtttatgcaa ataaccgtac agggcttctt gtggatcttt
    10861 ctaaaatatt tacagaacgt aagatcgacc tgcgaagtat caacagccgt acaagcaagc
    10921 aggagaaggc aactatttcc atgagttttg agattggaag caaagaggaa ctgcgttccc
    10981 tgctcgagaa gatccgtcag gtagagagtg tcattgacgt agagagaact acaggctgat
    11041 catggaaaaa tctgctggaa cattatttta tggaactgct gcagattgac agaaaggaat
    11101 aacatgaaga atttagaatt acagaaatgt atattaggac ctgtatatac aaattgctat
    11161 ctccttaaga ataaagaaac cggagaactg atcattgttg atcccgcaga ttgtccggag
    11221 aagattgaaa tgaagatttc ccggatgaat ggaaaaccgg tggcgattct tcttacccat
    11281 ggacattttg accacattct ggctgcacag gcagtaaagg agaaatataa tattccgatt
    11341 tatgcctgtc atcaggaaga ggagatgctc cgcgaacctt cgatcaatat gactgtacat
    11401 tatggacagg gatgttctat tgtgccggat gtatttctgg aggatctgga tgttatcaga
    11461 ctggcgggat tttccgttca gatgatccat acaccgggac ataccaaagg aagctgctgt
    11521 tattatctga aagatgaagg tgtattgttc agcggtgata cagtgttcta tggctctgtt
    11581 ggaagaacgg attttccggg tggaagtaca gcagaaatcg tgagaagtct ccataaactg
    11641 gtagattcgc ttcctgaaga gaccgaggtt ttccccggac atgatgcatc taccactatt
    11701 ggttatgaaa agaggtataa tccatttgtg taaaataggc attctgtttg agaacagaga
    11761 ttttgaacat gatgtttatg aactgatcaa agcgttttat cccgaagcgg agatacatac
    11821 tctttatgaa aatgctgaag cagagtatga cctccgcttc agtgtggaac gggataatga
    11881 cagttatatc ataaaatacg aaaggacaga gaatctgtcg aaacaggaaa cagagcaaaa
    11941 aggggtaatt tccgcagaca tactttctaa agagaatgca ggctgtggaa tacaggatgc
    12001 tcatgctctg agaaaagaga ataaagataa tatcaaatat gctctgtatc agttgttggt
    12061 aaaactgacg ggcagaactc ttccatgggg aaatctgaca ggaatacgtc ctgccaaact
    12121 ggcaatggga atgatcgaat ccggaatgaa aaatacggaa gcagcccggg agatgcgtga
    12181 gagatatctg gtaagtccgc agaaaacagc gcttgccatc actattgcaa acagggaaag
    12241 agagattctg aaggatattg actatgaaaa tggatacagc ctttatattg gaatcccgtt
    12301 ttgcccaagt atctgtctgt attgttcctt cagctcctat ccgctgaaag tgtgggagaa
    12361 gagaacagat gaatatgtgg aagctctctg ccgggaggta agagagactg ctcttatgat
    12421 gaagggaaga aaactggaca ccatctatat tggcggcggt accccgacta cactgcttcc
    12481 acatcagatc cgtaagctcc tggatacagt gggagaagct tttggctatg aaggactggc
    12541 agagtttact gtggaagccg gcagaccgga cagtattaca cgtgaaaagc tgatggcgat
    12601 cagggagtat ccggtaacaa gaatttccgt aaatccacag actatgaatc aggaaaccct
    12661 ggatattatc ggccgcagac atactgtgga gcagacaaaa gaagcgtttc atctggcacg
    12721 agagctggga tacgataaca ttaacatgga tctgatcgta ggtcttccgg gtgaggatat
    12781 tcacatggta gagcggactc ttgaacaggt tcgtgaactg gcaccggaca gtattaccgt
    12841 acattcactg gcagtgaaac gtgcagcaag gctgaatatt tttaaagaga aatatcagga
    12901 aatgtctttt gagaataatc aggagattat ggatctgacc atgaaaaccg catatgaaat
    12961 gggaatgggt ccttattatc tgtacagaca gaagaatatg aagggaaatt ttgaaaatgt
    13021 tggctatgca aaggttgaca aagcgggaat ttacaatata ctgattatgg aggaaaaaca
    13081 gcctatcatc gcactggggg caggcggttc ttccaagctg gtctttgacc atggacagag
    13141 aattgaacgt gtggagaatg taaaagacgt ttctaattat atttcccgca ttgatgagat
    13201 gatcgagaga aaacggacag caatagctac ctggctgtag gatgtggagg taacattttg
    13261 gacacagtac aaaagacagc ggcaggttca cagcagagga tcctggaatt tgaccttgct
    13321 tctgaactgc atcatggaat gctggtaagt aatctggctt atgcggttgc agaggagatg
    13381 ggactgccgc atgaacagtg ctatgagctt gcaatagcag gaatgctcca tgatatagga
    13441 aagctgaagc tgacaagtta tattaacgga caggagcagg atcctctggt gatcgaggaa
    13501 ctgaagtatg tccggatgca ttctacattg ggatatgagg aacttaaagg gcagggatat
    13561 tcggattttg tattggagag tatcctgtac catcatgaga attatgatgg cagtggatat
    13621 ccgtccaata aagcaggtga tgacataccc ataggtgccc ggatactcag agtctgcgat
    13681 gtata
//
