LOCUS       c00126_gnlPro..        13417 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NJKIFNDI_126.
ACCESSION   c00126_gnlPro..
VERSION     c00126_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:28:17
            Original ID  :: gnl|Prokka|NJKIFNDI_126
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13417
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13417
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[168:3417]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      169..3417
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13417
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13417
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(3..134)
                     /locus_tag="ctg126_1"
                     /transl_table=11
                     /translation="MEVTEKNRTKYRLPGEFEPHEGCVLILPERPGSWNYGAREAQKA"
     CDS             complement(169..1290)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg126_2"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 5.1e-15,
                     bitscore: 46.4, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(1280..2518)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg126_3"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 9.1e-44, bitscore:
                     141.2, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.1e-29,
                     bitscore: 94.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VAIRKCCQNSDVFTEIMIASRTKEKCDALKEKIESTTKTKIETAK
                     VDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYIDTANYEAEDTEDPT
                     WRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDPGVTSVFSAYALKHY
                     FDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGHWVETEPMEFKSVYD
                     FPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMKCLENVGMLSTAPVE
                     FNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEKSIYIYNVCDHQECY
                     KEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYMEALNKWGLPWKVCE
                     DPELVKVWKANED"
     CDS             complement(2557..3417)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg126_4"
                     /sec_met_domain="Spermine_synth (E-value: 8.1e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.2e-15,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(3420..4931)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg126_5"
                     /sec_met_domain="OKR_DC_1_C (E-value: 6.9e-14, bitscore:
                     43.1, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.6e-126,
                     bitscore: 412.8, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIELYLPVHDDRKRGTCQMDYERQQHAPIYEALERFRKKRVVPFD
                     VPGHKRGRGNPELAQLLGEKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAF
                     LMVGGTTSAVQSMILSVCKAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGIS
                     LGMEVSQVEKAMDENPDAVAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHL
                     YFGRNLPVSGMAAGADMAAVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSAS
                     YLLLSSLDISRRNLALRGEESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFD
                     VTKLSIYTLGNGLAGIEVYDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALA
                     DIERLYKKDSTGMLSGEYIAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGI
                     PILAPGEMVTQEIVEYILYARDKGCSMQGMEDPKVEHLQVLKGGI"
     CDS             5940..7625
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg126_6"
                     /sec_met_domain="FTHFS (E-value: 1.1e-275, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(7734..9158)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg126_7"
                     /sec_met_domain="Lyase_1 (E-value: 6.1e-95, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 9.4e-23, bitscore:
                     71.3, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPL
                     HMTEPGISGKDYLIKK"
     CDS             9274..10209
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg126_8"
                     /sec_met_domain="LysR_substrate (E-value: 1.1e-33,
                     bitscore: 107.1, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 9.6e-19, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFEHYIYQKEQ
                     LLLAVPKNYSVNTRLQEYQIPIEEIRNEQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(10321..11778)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg126_9"
                     /sec_met_domain="FGGY_C (E-value: 1.8e-38, bitscore: 123.0,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 1.1e-80, bitscore: 261.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFAQSMEGMKELTKDIDRAQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARNLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
     CDS             complement(11923..13404)
                     /locus_tag="ctg126_10"
                     /transl_table=11
                     /translation="MNNIPVVKLGLIAVSRDCFPIQLSEKRRAAIKETYKGELYECPVT
                     VENEKDMEKALEDVNKAECNALVVFLGNFGPETPETLIAERFDGPCMYVAAAEGDGDMI
                     NGRGDAYCGMLNCSYNLKMRHLKAYIPEYPVGTADDIAKMIADFVPVARAVIGVSNLKI
                     ITFGPRPQDFFACNAPIKGLYELGVEIEENSELDLLVSFKEHENDPRIPEVCADMAKEM
                     GEGKYYADLNVKMAQFELTLLDWAEAHKGARKYVAFADKCWPAFPSQFGFEPCYVNSRL
                     ASRGIPVSCEVDIYGALSEYIGLCISNDAVTLLDINNSVPQYIYDEDIKGKYDYKLTDT
                     FMGFHCGNTPACKMCDSRAVKYQLIQHRLLEPAGSEPDFTRGTLEGDIAASDITFYRLQ
                     CNSEGELVSYVAEGEVLDVPTRSFGGIGIFAIKEMGRFYRHVLIEGNYPHHGAVMFGHY
                     GKAFYEVVKFLGLDVKKIGYNQPAGVRYPTENPWG"
ORIGIN
        1 aatgctttct gtgcttccct tgccccataa ttccatgaac cgggacgttc cggcaagatc
       61 aacacacatc cctcatgagg ctcaaattct ccgggcagac gatattttgt tctgttcttc
      121 tctgtaactt ccatgtctgt ctccttttct ttgatagccc ggcagatatc aggaaagccg
      181 gctcttaaag tcttcgtatc cgaaatgtct gataacctca cactctccgt cctcatgcat
      241 aaccgcaata tccggcagcg gcataccgtt aaatgtatta ttcttcacca tagaataaat
      301 cgccatatcc ataaaatata gcttgtcccc gatccggatc tctctgtcaa aggaataatc
      361 tccgattaca tctcctgcca ggcaggtgca agaagataag cggtaggtat atgccttctc
      421 ccctgcttcc ccgctgtcct taagaggcgg acgatagggc atctccagca catccggcat
      481 atggcaggct gcagaagcat ccaaaatcag cgttctgatc tcattttcca caatgtccat
      541 aacctctgtc accagatatc cggcattcag ggcaacagcc tccccgggct ccagataaat
      601 atccagatca taggtttcct tcatatgctg aatacatttt tccaggagct ttacatcata
      661 atcctctctg gtaatatgat gtccgccgcc catattcagc caggaaacct cagacagaaa
      721 ttctccaaac ttctcctcta ccgcctgcaa tgttttctcc aggtcatccg cattctgttc
      781 gcagagcgta tgaaaatgca gtccgtcgat ccatttcaga cattccccgt caaagttctc
      841 tctggtaacc cccagccttg aacccggcgc acagggatca tagatcgcat gatccccctg
      901 agtggagcat tccggattaa tacggagtcc cagactggct ccggtacaca cttctttaaa
      961 tttcttcagc tgtgctgtgg aattaaagat aatatggtca cagatccgat ccagttcctc
     1021 tatatcttct gtacggtaag caggggaaaa aacatgattc tctttcccca tctcttcata
     1081 tccaagcctt gcctcaaaca gaccgctggc agtggtacct gccagatatt ttccgatcat
     1141 gggatacaga gcaaagccgg aaaacgcttt ctgcgccaga aggatcttac acccggtatc
     1201 ctcctggact tttttcaaaa tctccagatt ctcccgcatc ttcttctcat cgatcacata
     1261 gcagggagtt tgcagttgat caatcttcat tggctttcca gacctttacc agttcaggat
     1321 cttcgcagac tttccatgga agtccccatt tgttcagtgc ttccatatat ggatccggat
     1381 caaattcttc cacattaaat acacccggct tcttccactg tccggtcact accatcatgg
     1441 aaccaatcat agccggaaca cctgttgtat aggagattgc ctgggattcc acctctttat
     1501 aacattcctg atgatcacat acattataaa tataaatact tttctctttt ccgtccttaa
     1561 cacctgtgaa aatacagccg atatttgttt tacccactgt tctcggaccc agagatgcag
     1621 gatccggcag aagagctttc aaaaactgga tcggcacgat ctcctgtcca ttaaattcca
     1681 caggtgcggt ggaaagcatt cctacatttt ccagacattt catatgtgtc agatagctct
     1741 gtccgaatgt cataaagaaa cggatcctct gtactcccgg aatatttttt gccagtgatt
     1801 caatctcttc atgatgaaga agatacatat ccttctttcc tacctcaggg aaatcgtaga
     1861 cagatttaaa ttccataggc tctgtttcta cccaatgtcc gtcttcccag taggaaccat
     1921 ttgcggaaac ctctcgaaga ttgatctccg ggttaaagtt tgtggcaaaa ggatatccat
     1981 gatcaccgcc gttacagtcc agaatatcaa tggtatggat ttcatcaaaa taatgcttca
     2041 aggcataggc actgaataca ctggtaacac ccggatcaaa accggttccc agaagagcag
     2101 tcagtcctgc ttccttaaat ttctcatcat aagcccactg ccaggaataa tcgaaatatg
     2161 cagtaaagcc tttttcttta catctctttt catagattgc acgccatgtg ggatcttctg
     2221 tatcctctgc ttcataattg gcagtatcaa tataatccgc accggcttcc agacatgcat
     2281 ccatgatggt aagatcctga tatggaagtg ccacattcag gacagcatcc ggcttatagg
     2341 ctctgatcaa ttctgcgacc tctgctgcat tatccgcatc tacctttgct gtctcaattt
     2401 ttgtcttcgt tgtactttca atcttctctt tgagtgcatc gcatttttcc tttgtcctgc
     2461 ttgcgatcat aatctctgta aaaacatcgc tgttctgaca gcatttgcga attgccactg
     2521 aagctacccc accacatccg attaccaata atctgctcat aaactgtttt cctcctcttc
     2581 cagtaaatct tctacatatt ttggaagcat aaatgctcct ctgtgaaggt ttgttgtata
     2641 ataccatgtt tctatattaa gattatcaaa cctctccggc ctgaaatctt ccagtggatg
     2701 atatttcttt gatgcaaatc caaaaagcca gtatcccgag ggacaggtag ggatatgtgc
     2761 ctgataaacc ctgctcaccg gaaatgaccg gaaaaccttt ctgtgcatct ttctgcattc
     2821 cacctcatcc tcatcataaa aaggacttcc atgctgataa accatgattc cgtcatctct
     2881 gagagcctta taacagcttc cgtagaattc ctttgtaaaa agtccctctg tatgtcccag
     2941 cggatctgtg gaatcattga tgatcaggtc atatctggcc tttttattcc gcaggaaccg
     3001 aaggccgtct tcataataaa tgttgactct ctcatccttc agtccctggg caatatccgg
     3061 aaacatctcc gcacatacat ccacaaacat tttatcggat tccaccacat caatgctctc
     3121 aatctgtgga taatggatca gttctctggc aactccaccg tcaccgccgc cgatgatcag
     3181 aacatttttt acattgggat gtactgtcat tggcacatgc gtgaccattt catcataaat
     3241 aaattcatcc ttgtcagaaa atacgatctc accgtccaga gccacaaatc ttccaaattc
     3301 ttcagactca aacacatcga ttctctgaaa ttcactttcc cctgaaaata actgtcggtt
     3361 aatccggaca gaaagcttta catttcctgt atggaactcg gaataccata attccatgat
     3421 cagatacccc ctttcaggac ctgaagatgt tctaccttcg gatcctccat tccctgcatg
     3481 gaacagcctt tgtctcttgc ataaagaatg tattctacaa tttcctgtgt caccatttcc
     3541 ccaggagcaa gaatcgggat tcccggagga taacacataa caaattcacc gctgatcctg
     3601 cctgccgcct gttccatggg cagagattct ttctccgcat aaaacgcctg ctgtggagac
     3661 gccaccactg caggtgcgat atattccccg gaaagcatac ctgtgctgtc cttcttatac
     3721 agacgttcaa tatcagccaa tgcccctacc agtctctcaa tatcctgaag cctgtctccg
     3781 atggaaatgt aagccagaat attacagata tctccaaact cgatctgaat atcatattca
     3841 tctctgagaa gatcataaac ttcaatacct gccagcccat ttcccaatgt ataaatggag
     3901 agttttgtaa catcaaaatc aaaaacactg gttccattga tcagatccat accatatgca
     3961 taatagccgc cgatctcatt gatctcctct ctggcatact gcgccatccc tgcaaccttt
     4021 tcaaaggatt cctctcccct gagtgccaga tttcttctgg agatatccag actggacaac
     4081 agaagataag aagcacttgt ggtctgagtc agattgatga tctggcgcac tttctctgca
     4141 ttcatactct tattcaaaag cagcagcgaa ctctgtgtca gacttccgcc ggatttgtgc
     4201 atggaaactg ccgccatgtc agcacctgcc gccattccgg atacaggaag gtttctgccg
     4261 aaataaagat gggttccatg agcctcatct gccagcacct tcattcctct tgcatgagcc
     4321 ttctttacga tagtccgcag atccgaacag attccataat aggtagggtt atttacaaga
     4381 accgccaccg catccggatt ctcatccata gccttctcca cctgactgac ttccatgcca
     4441 agggaaatgc ccagctgcgc attcacctcc gggtttacat aaaccggaat tgcaccgcac
     4501 agtaccaggg cattgatggc acttttatgt acatttcgcg gcagaatgat cttatcccct
     4561 gccttgcaga cagacaggat catgctctgc actgcagatg tggttcctcc taccataagg
     4621 aatgcatgcg ctgcgccaaa agcatctgct gcaagctcct ccgcttctct gatcaccgaa
     4681 accgggtggc agagattgtc cagcggcttc atagaattaa catccagccc cacacatttc
     4741 tctcccagca actgtgcaag ctccggattt cctcttcctc ttttatgtcc cggcacatca
     4801 aagggaacga ctctcttctt tcggaaacgt tccagtgctt catatatggg cgcatgctgt
     4861 tgtctttcat aatccatttg acatgttcct cttttcctgt cgtcatgtac cggcaaatac
     4921 agttctatca ttcagcaatt gtatactgcc tcaaaccggc acaatgattc aattatttct
     4981 ctatatattt gctatatctg cacaaaaaaa gaagcagata agttcattca ccatctgctt
     5041 ctctcatgat ctatagaatt tctcaggctc tgtctcttta tatactgacc ggatttcccg
     5101 tataaatccg tctgtatcct gtgcctgttc ccgtattctg aaatattcat gactgctgtc
     5161 gtcttcaatc gctggcaaat atatgctatg ctcttattga ccgtttcaca agatgatgtg
     5221 tgcttacgca ctgattatta taaagtaatc aacttataaa atttgagctt ctaactcaat
     5281 caataatgtg gtgtctccca cccggcaact gccccgcctg tccgtatggc ttaacattca
     5341 gaaactgtct ctgaatgtga gcaaatattt gcatgaaaac gatagtgtct tttcatacta
     5401 aagatgagaa taacatatct tctgaactgt tgtcaattcc attttccata ttttgcacag
     5461 tctttacccg ctttttatat tttcttcatt tgtcagggaa aactgtgttt attttttaac
     5521 aatttcttcc cttgagaaaa cgtattttct ttcattacca aggattacga ttctcttctc
     5581 ttatcaattt gcacaacttt tatccagttt actcacattt tttgacgttt caacaaaaat
     5641 tttcttgaca tttttttctc aaaatgatat attgtattca tcaattgaaa gaaccttcga
     5701 gtactgacgg aaagagtgga gtgcaaacca cgtggagtcg gaggtttgtg ggagccgacc
     5761 gtctgggcag tatttgaaat attcagatac tggccttttt ttataacttt cagggcagaa
     5821 atcaggaata ccaggcagac cggccaatac ttctttcaat taataattgt tgctgatcgc
     5881 agagtgaaca gcaacagaag tttttcatgt tatgcggaaa cgaaaggaga aaaacaatta
     5941 tgggatttaa atcagacatt gaaattgcac aggaatgcga gatgcttcca attactcaga
     6001 tcgcagagaa agcaggtatt gacgacaaat atctggagca gtacggaaaa tacaaagcaa
     6061 aaatcgacta caatcttctg aaagaaagtg ataagaagga cggaaaatta atcctcgtta
     6121 cagctatcaa cccaactcca gcaggagaag gtaaaactac tactactgta ggtcttgcag
     6181 atggtatgca gagacttggc aagagtgtta tggtagctct tcgtgagcca tccttaggac
     6241 cggtattcgg tgtaaaaggt ggtgcagcag gcggcggata tgcacaggtt gttcctatgg
     6301 aagatattaa ccttcacttc acaggtgact tccatgccat tggcgcagct aacaacttac
     6361 tggcagctat gatcgataac catatcttcc agggcaatgc attaaacatc gacccacgta
     6421 agatcacatg gagaagatgt gtagatatga acgaccgtca gcttcgtaac gtagtagatg
     6481 gtcttggcgg aaagacaaac ggtatgcctc gtgaagacgg atacgacatc acagttgcat
     6541 ctgaaatcat ggcagttctc tgtcttgcaa gcgacatcaa agacctgaaa gaaagattat
     6601 ccaagatcat catcggatat acatacggaa aagtttccga gcagaaacct gtaacagcag
     6661 gtgaccttca cgcagaaggc gctatgacag ccctgttaaa agatgctctg aaaccaaacc
     6721 ttgtacagac tctggaacac gttcctgcaa tcgtacatgg cggaccattc gcaaacatcg
     6781 ctcatggatg taactctgta acagctacaa agatggctat gaagcttgct gattatgcaa
     6841 tcacagaagc tggtttcggt gctgaccttg gtgctgagaa attccttgat atcaaatgcc
     6901 gtatggctgg tttaaaacca agcgcagttg taatcgtagc tacagtacgt gccctgaaat
     6961 acaacggcgg cgttgctaaa gctgacctta acaatgaaaa cctggaagct cttgaaaaag
     7021 gtatcccgaa cctgttaaaa cacgtttcca acatcaaaaa cgtatacaaa cttccatgtg
     7081 ttgttgctat caacgcattc cctacagata caaaagcaga gcttgacttt gtagaagcta
     7141 aatgtaaaga actgggcgtt aacgttgctc tttctgaagt atgggcaaaa ggcggcgaag
     7201 gcggaatcaa acttgcagaa gaagttatcc gtcttgttga agaaccaaac gacttctcct
     7261 atgcatatga actggaaggt tctatcgaag acaaactgaa ccagatcgtt cagaaagtat
     7321 atggcggtaa gaaagtagtt ctgacagcta acgctcagaa acaggcgaaa cagttagaag
     7381 ctcttggatt cggcaactgc ccgatctgtg tagctaagac tcagtacagc ttaacagatg
     7441 accagaccaa actgggtgct cctactgact tcgaagttac agtacgtaac ctgaagattt
     7501 ccgctggtgc aggattcatc gtagctctta caggtgagat catgacaatg ccaggtcttc
     7561 ctaaagttcc ggctgctgag agaatcgacg tagacgagac aggtaagatc acaggtctgt
     7621 tctaatccgg ttgaaatcaa tcgaataatt caaaaatata aaaatcatat ttatatatga
     7681 tatgtgtcca gacgatttta caggcgggaa gattttccag cctgtttttt tctttatttt
     7741 tttataagat aatcttttcc ggaaatacca ggttccgtca tatggagcgg atccagaatg
     7801 cgattaagtt catcctcgtc cataagcttt tctttcagaa tcagacttct tacagattcg
     7861 cctgtcttaa ttgccttttt tgcaatatcc gcagccttct gatatccaag atgggggctg
     7921 attgcagtga taatacctac actgttttct accagataac ggcatctttc ttcatttgcc
     7981 gtaattccta caatacaatt atctaccaat gtctggactg catagccaag agtatcgata
     8041 gactggaaca tgcaatagaa aataatcggc tcaaacgcat ttaattccag ctgaccagcc
     8101 tctgcagcca tggtaatggt aacatcatta ccaataatat taaaagcaac ctgattcact
     8161 acttcaggaa taaccggatt aactttacct ggcataatag aggaaccatt ctgttttgcc
     8221 ggaagattaa tctccccaaa accagtacgt ggaccggagg acatcagacg gagatcattt
     8281 gacattttgg aaagagttac cgcacatgct ttcacagcac cggaaacggc tacaaatgga
     8341 tccagattct gagtggaatc aatcagatca aaagcctgta taaagtccat tcccgatatt
     8401 tcagtgagat ttggaacaat tcttctcaga tagccctcat ctgcattaat tcctgttcca
     8461 atagcagtac ctcccatatt aagagtccgc atttcatcca ttgctttatc cattctgtgg
     8521 atatcacgca tgattgctac cgaatatgcc ttaaattcct gtcccagacg aattggtact
     8581 gcatcctgca tctgtgtacg ccccattttt attatgtgat caaactctgt agctttttca
     8641 ttaagagcat catagaggcg aagaagctgt tttttcagat tctgcaacaa acgaagagaa
     8701 gtcattttac cggcagtagg aataacgtca ttggtagact gtccacaatt cacatcatcg
     8761 ttaggattta taattgtata atcgcccttt tttcctccca gtatctcaat cgcgcgattt
     8821 gcaattactt cattggcatt catatttaaa gatgtgccag ctcctccctg aacaggatcc
     8881 acaataaatt cattatggaa ttttcctgaa acaatttcat cacatgcctg gacaatcgcc
     8941 tgtgcttttt tcttctcaag aagccccacc tcacaattgg ttatcgctgc tgcttttttt
     9001 atgtatgcaa gactgttaat aatttccgga tgcatattca gccccgtaat gtggaaattt
     9061 tcagccgcac gtaaggattg tactccataa tatacatctt ccggaatatc ctttacacca
     9121 atagaatccc tttctacacg atagtctgtt tttttcatag ttattcgccc tcccatgtat
     9181 ttgccctcat tatatatctc tgctataata taatcaaata catatatttt tataaaatat
     9241 atagtgttta agttatatat cggaggagtt tatatgtttc agggaatgga atacatctat
     9301 gaggtctaca aggaaaaaag cttttccaaa gctgctgctg ctcttttcat ttcgcagcct
     9361 tctttaagtg caaatgtaaa acgtgtggaa aaccgcattg gttatcctat ttttgatcga
     9421 agtaccaaac ctttacagtt aactgaagtc ggaaaacatt atatacaggc tgttgaaaaa
     9481 gtcatggata ttgaaaataa tctcgaaaac tacctactgg atctaggaaa tctcaaaaca
     9541 ggaactctta atgtaggtgg cagtaacttt ttttcttcgt ggattctgcc tccccttatt
     9601 gctgattttt cccaaaaatt cccccatgtt caaatttctc ttgtagaaga aagtacagca
     9661 aagctatccc agtttctcca ggccggaaag ttagatctgg taattgataa ctgtattctg
     9721 gataaccaga tttttgaaca ttatatctac cagaaagaac aacttcttct agcggttccc
     9781 aaaaattatt cagtaaatac ccgactgcag gaatatcaga ttcctattga ggaaatccgg
     9841 aacgaacagt tccgttcttc tcatattcct tctgttccat taaacaaatt cgagaacgaa
     9901 ccatttatta ttcttcgttc agataatgat accggtaagc gtgcacttac catttgtcag
     9961 gaaaatcact tttcgccttc tgtagtattt cgcctggatc agcagatgac tgcctataat
    10021 attgcatgtt tgggaatggg tatcactttc atcggggatc ttctgctctc cagagttcca
    10081 acaaattcag aacttgtttt ttataagcta cccggtcaga gcagtaaacg cactgtgttt
    10141 ttttactgga agaaaggccg ctatatcagc agagccatgg aagaattcct gaagctgccc
    10201 ttttcctgat atgtcataat caaataggtt atggtgattg gtcatcatca gatgtacgtc
    10261 aaaatggggt tgttgtgcta aataagcaca acaaccccag tatgtcaggc agatattcga
    10321 ttagaacaat ggcttcatcg ccggatacag agttctgaac ttctgatatc tctcttcata
    10381 ttttgcaacc agttcaggat ccggttctac tgtatcaaca actttggcaa atttcttacc
    10441 gatggtttct acatccgggt aagcaccaca gcctactgct gccagcatag ctccacccat
    10501 ggacggtcct tcttcgttct ccagaacatc aaccttcagg ttcataacgt ttgcaatgat
    10561 cttcttccac agtgggctct tagctccacc accgcagatc ttggttctct caatcttgat
    10621 tccaaggttt cttgcaactt ccagggaatc acgaagacca aaggcaacac cttccagaac
    10681 agcctgtgtc atgtctgctc ttgtgctgtc catggacatt ccgaagaata cacctcttgc
    10741 atcaggatta ttatgaggtg aacgttctcc catcaaatat ggaaggaaga atacatgatt
    10801 ctctcccagc ttctgaattg gagcctgctc tgctgcgaaa tcctttgtct gaagaatctc
    10861 ctctgcccac catttgttac aggaagctgc gctgagcatg catcccatca gatgatagct
    10921 tccatctgca tgacagaaag aatgaagtgc gttattttcg tccacaccaa agtttttact
    10981 ggaaataaac acagttccgg atgttccaag agaaatatta cactgaccgt caccaactgt
    11041 acctgttcct acagcagctg ccgcattgtc acctgcacct gcaacaactt ttacattctc
    11101 actgaatcca agttctttcg caatctcagg tttcagagtt cctactactt cccaactctc
    11161 atacagtttc ggaagctgct cttctgtgat tccacagatc tccagcattt cttttgacca
    11221 gcagcggttc ttcacatcaa gaagaagcat accggaagca tcagaaacat ctgtacaaaa
    11281 agaaccggac agacgatatg ccagataatc cttaggaagc ataatcttta ctaccttctt
    11341 aaagttctca ggctcatttt tctgcatcca gaggatcttc ggtgctgtga agcctgcgaa
    11401 agcaatattt gctgtatact gtgaaagttt gtcttttccg atcactgtat tcagatattc
    11461 tgtctcttcg cctgtacgtc cgtcattcca gaggattgca ggacggatca cattatcatc
    11521 cttgtcaagt gttaccagac catgcatctg gccgccaaaa ccaattcctg ctacctgcgc
    11581 tctgtcgata tcctttgtca gctctttcat accttccata ctctgtgcaa accagtcttc
    11641 cggtttctgc tcagaccagc ccggatgtgg gaagaataaa ggatattctc tggatacgat
    11701 gttacagatt tttcctgatt cttccataag aagaagtttt acagcggaag taccaaggtc
    11761 aataccaata taatacataa gtgctctcct tttctatttc taatctaata catcccagag
    11821 caaagccccg ggatgccttt aatatagtgt cagtttattt attctgtatt cagattcatt
    11881 cacttcacat gaacattaat aatccgtttt actgatttct cattaacccc atggattttc
    11941 tgtcgggtat cttacacctg ccggctggtt atatccaatc ttcttaacat ccagtccaag
    12001 gaatttcact acctcataga atgcttttcc gtaatgtcca aacataactg ctccatgatg
    12061 cggatagttg ccctcgatca gtacgtgacg gtagaatctt cccatttctt tgattgcgaa
    12121 aataccgata ccaccgaatg atcttgtagg tacatccagt acttcacctt ctgcaacata
    12181 agaaaccagc tcgccctcgg aattgcactg taaacgatag aatgtaatgt cagatgcagc
    12241 gatatcacct tcaagagttc ctcttgtgaa gtctggttca gatcctgccg gctcaagaag
    12301 tctgtgctgg atcagctgat atttaacagc tctggaatca cacatcttgc atgcaggagt
    12361 atttccacaa tggaatccca taaatgtatc agtaagctta taatcgtatt ttcctttaat
    12421 atcttcatca tagatatact gtggaacaga gttgttgata tcaagcagtg taactgcatc
    12481 attggaaatg caaagtccga tgtactcgct gagtgctccg tagatatcaa cctcacagga
    12541 taccgggatt cctctggaag ccagacggct gtttacatag caaggttcaa atccaaactg
    12601 tgacgggaat gctggccagc atttgtcagc aaatgcaacg tattttcttg ctcccttatg
    12661 agcctctgcc cagtcaagaa gtgtaagctc aaactgtgcc attttcacat taaggtcagc
    12721 ataatatttg ccttcgccca tctctttggc catatctgca caaacttccg ggatacgagg
    12781 gtcattttca tgctctttga aagaaacaag aagatcaagc tctgagttct cttcaatctc
    12841 aacgcccagc tcatagaggc ctttaatagg tgcgttgcat gcgaagaagt cctgtggacg
    12901 cggtccaaaa gtaatgatct taagattgct gacaccgatg actgcacgtg caaccggtac
    12961 gaaatcagcg atcatctttg caatatcatc tgctgttcca acaggatatt ccggaatata
    13021 tgctttcaga tgacgcattt ttaagttgta ggagcagtta agcataccac agtaagcatc
    13081 acctctgccg ttgatcatat cgccgtcacc ttctgctgct gctacataca tgcaaggtcc
    13141 gtcaaatctc tctgcgatca gagtttcagg agtttcaggt ccgaagtttc caaggaaaac
    13201 aaccagcgca ttacactctg ctttgtttac atcttcaaga gctttctcca tatccttttc
    13261 attctcaaca gttacaggac attcataaag ttcaccttta taagtttcct tgattgctgc
    13321 acgtctcttc tcagaaagct gaatcggaaa acagtcacgg cttactgcaa ttaatccaag
    13381 ttttactact ggtatattgt tcataatata aattcct
//
