LOCUS       c00234_gnlPro..        15499 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NJKIFNDI_234.
ACCESSION   c00234_gnlPro..
VERSION     c00234_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:28:17
            Original ID  :: gnl|Prokka|NJKIFNDI_234
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15499
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15499
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[176:5499]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      177..5499
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15499
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15499
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             177..1613
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg234_1"
                     /sec_met_domain="CT_Vparvula (E-value: 1.9e-136, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             1661..2383
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg234_2"
                     /sec_met_domain="OAD_gamma (E-value: 1.1e-27, bitscore:
                     86.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSAVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     ADANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             2411..2779
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63; E-value:
                     6e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg234_3"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.8e-20, bitscore:
                     63.0, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVVILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             2796..3944
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg234_4"
                     /sec_met_domain="OAD_beta (E-value: 7.5e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFSLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             4087..5499
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg234_5"
                     /sec_met_domain="HMGL-like (E-value: 6.4e-47, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 7.2e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             5611..7071
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg234_6"
                     /sec_met_domain="HI0933_like (E-value: 5.3e-128, bitscore:
                     417.3, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPVVHIYIDRSEAETWNYDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTESVTDSVNTLESEAALTESGSDAGKSKKGKKSPDIPQEKITGVILT
                     DGTFMEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKL
                     QGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSA
                     YLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHD
                     ISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGE
                     VLDLDAVTGGYNLQIAWSTAYLAAQAIQ"
     CDS             7257..7928
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg234_7"
                     /sec_met_domain="Cytidylate_kin (E-value: 3e-78, bitscore:
                     252.6, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLL
                     NHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANP
                     KVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKG
                     ESFDLDQIRKDIIERDERDMNREISPLKQAEDAVLVDSSEMGIDDVVNAILNVYKEKVQ
                     K"
     CDS             7947..8825
                     /locus_tag="ctg234_8"
                     /transl_table=11
                     /translation="MKVKVAETAGFCFGVKRAVNKVYELIDTEQKPIFTLGPIIHNEGV
                     VADLEARGVHVITEADLDFPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFV
                     LKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIKNQEEAEAFVPPKGKKI
                     SIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDT
                     MLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKII
                     EEVQEHVRIKF"
     CDS             8830..9882
                     /locus_tag="ctg234_9"
                     /transl_table=11
                     /translation="MLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADGIITKNEYS
                     NDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAFENQEVLKA
                     PVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNPRRRRIIGN
                     RKQLLLAEKAEKQKELMERIHVGDTVEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRV
                     ENPKKVFTVGDKVKVLIKEINGEKIALSLKFPEANPWLTAAEDFAVGNVVKGKVARMTD
                     FGAFVELAPGVDALLHVSQISREHVAKPADVLSIGQEIEAKVVDFNGEDKKISLSMKAL
                     EAPAEEAAEE"
     CDS             9910..10011
                     /locus_tag="ctg234_10"
                     /transl_table=11
                     /translation="MNIYQPALYEIDHTEPVDFSDYKYGQQLQENYK"
     CDS             10065..10703
                     /locus_tag="ctg234_11"
                     /transl_table=11
                     /translation="MSGKGIYDIHCHIVPGVDDGATDIEETGKLLRMEYEQGVRTIIAT
                     PHFRFRMFETSAEKVKEQFKLVEKAAAEVASDLHVYLGCEFHTNMEMISMLRENKVMTM
                     AGSRYVLTEFSHNSEENYIRERLSTLLSGGYKPIVAHIERYEATRTNMDFVEELVDMGV
                     CMQINADSITGKIAEPSSATFISSSQGYLVPKISLHCILPRRVPSFDQK"
     CDS             complement(11644..13020)
                     /locus_tag="ctg234_12"
                     /transl_table=11
                     /translation="MNTTANLGKAPVRTLVLQLAIPSMTAQFVNVLYSIIDRMYIGHIS
                     QNGALALAGAGVCGPIVTFLTSFGTLVGIGGSITMGIRMGEKNHKKAEQVLANSFLVLS
                     IFSVLLTISFLLLKDKLLMWFGASGATFPFANTYLTIYTTSTFFALMATGLNYFINCQG
                     FPLVGMFTVLIGAGCNILLDPIFIFGFHMGISGAAIATVISQILSCIFAMTFLLGKKVP
                     VKITFGQYNLKVIKKILSLGFSPFLILATDSLILIFMNTVLQKYGGASQGDILITCATI
                     AQSYLLLITSPMIGISGGTQAILSYNYGARCVNRVKDAERNILGVMLIFTTIMFLLSRF
                     IPRYFVLLFTTDPQYIRFSVWTIRTYTLMIIPLSFQYVFVDGLTALECPKTGLALSVTR
                     KSLFVISAAVLPSFFGAKAAFFAEPVADGISSVLSTVVFLLLINRHLDKRCQMDKEAIL
                     "
     CDS             13388..14446
                     /locus_tag="ctg234_13"
                     /transl_table=11
                     /translation="MAAGIGSRFGTGIKQLEPVDYAFQDINDIPGTLPEGRTKPWGTGQ
                     AVLAAKKVIKTPFIVINADDYYGKEGFKAVHEYLVNGGKSCMAGFVLKNTLSDNGGVTR
                     GICKMDEDYNLTEVVETKNIVKTAAVAEAEGMAVDVDSLVSMNMWGLTPDFLTTLEEGF
                     KEFFEKEVPGNPLKAEYLIPIFIGELLEHGKISVKVLKTNDTWYQKFKESVFFRKLFLL
                     FFVTSMILFRTLLNRNLWMNPLSKVMGGWGIWETVNGEQKLTTECIENVIIMVPFSSVV
                     MWTFKEKTGNGWKKILWYSGKIAFIFSVSIEMLQLLLRLGTFQLSDIFYNTVGGMLGGL
                     VYYVTMKARKHL"
     CDS             14579..15271
                     /locus_tag="ctg234_14"
                     /transl_table=11
                     /translation="MGKINENYVYKEPEEITIQRNKIHKNQRNIEDFIELIEENSQEMK
                     IQKLIKEDLSFMADYLAEPYEEYICFSNYPIGDKIADFVVLTSRSKMKVCIVEVKGADF
                     KTVKANHYQGLNVHMNDAITQLKNHMEYINRNYSSFRTQIHEDKDKAINEEYSGNYLVG
                     PRKNLLVDPQKDIDVKYIAIGGVEREDKSIEESHEIVKCKPADNLEIASWNSFVRKLDE
                     YHGHHPVQ"
ORIGIN
        1 ggaagaaata ctcaaaaaaa caaaatttgg agcaacctga caaatttttc tgctatattt
       61 ttaacgaaaa tgacaaataa atgttgaaat tttctgccga aaaaggtaaa attaaaatcg
      121 gctaaatttt tgggttaact tttaaatatt ctcataaaga tggagggcaa acaagaatga
      181 gtaatgcaac acaaagctta gcaggcacaa gaattacttc tttgcttgac gcaaacagtt
      241 ttgtcgaaat cggacagggt gtaacagcca gatccacaga tttcaacatg actgcaaaca
      301 aggcaccatc tgacggtgtt atcaccggat atggtgtgat cgatgacaaa ctggtttatg
      361 tatacagcca ggatgcatct gtattaaacg gtactgttgg tgaaatgcat gcaaagaaga
      421 tcacaagact ttatgatctt gccatgaaaa caggcgctcc ggttatcgga cttgttgact
      481 gtgcaggtat ccgtcttcag gaagcaacag acgcactgga agctttcgga cagatctatc
      541 tgaaacagac attggcatcc ggtgtgatcc cgcagatcac agcaatcttc ggaacatgcg
      601 gcggtggtat ggcagttatc ccgtccctga cagatttcac attcatggaa tccaaaaaag
      661 gaaaaatgtt cgtcaacaca ccaaacgcac tggaaggaaa caacacagac aaatgcgata
      721 cagcagcagc tgatttccag agcaaagaga caggtgtgat cgatggcgtt ggtacagagg
      781 atgagattct tggccagatc cgttccttag tatcacttct tccttctaat aatgaagaca
      841 cagacaatta cacagagtgt acagacgatc ttaaccgcgt atgcgcagat cttgcaaact
      901 gtgcaggtga cacagcaatc gcactttccc agatcgctga caacggtgaa ttcttcgaga
      961 caaaagcaga ctatgcaaaa gacatggtta caggctttat ccgtttaaac ggcgctacag
     1021 taggtgctgt tgcaaacaga agcgaagtat atgacgcaga aggcaagaaa acagaaacat
     1081 ttgacggaag catctctgca agaggcgcaa gaaaagcagc agatttcgtg aaattctgcg
     1141 acgcttttga tattccggta cttacactta caaacgcaac aggcttcatg gcaaccttat
     1201 gcagcgagaa gatgatggcg aaatccgtag gtgaactggt agctgcattc gcagatgcaa
     1261 ctgttccgaa ggtaaatgtg atcatcggca aagcttacgg tacagcttac gtggcaatga
     1321 acagcaaatc tatcggtgca gaccttgtat atgcatggga taacgcagag atcggtatga
     1381 tggatgcttc cctggcagcc aagatcatgt acgcagatgc agatgctgct gaactgaatg
     1441 aaaaagctgc tcagtacaga gagcttcaga atggtgttgc ttccgcagca gcaagaggct
     1501 atgttgacac tgtgatcagc ccggctgaca caagaaaata tgtaatcggt gcatttgaga
     1561 tgctgttcac aaagagagaa gatcgtccgt ctaagaaaca tggaacggtc taagcggggt
     1621 gacgcatatg aaaatgatca aaaaaataac ttctgtattc atgacatttc tcgtaatggc
     1681 tgcgctggtg atcggcagca cctctgcggt atttgccgca gataaggttg atgatactgt
     1741 taagtccaca ctggtaacta cagcagaagg actgacagat gccattgtcc agcttaaaga
     1801 tgaagaaatc gagaattaca tgagttcagg agatgacttt acaacaagtg ccatgcagtc
     1861 ctggcagaca tccaaggatg aacttggcgc aaagaaggac agcaatggtg aaaccactgt
     1921 aactttcaaa gatgatcagt acacagttac tgttcctctt aaatttgaga aagcagatgc
     1981 aaactttgta tatgtctttg actcacaggg aacaccgact tccatgtctg tagatgtaca
     2041 gtatggtatg ggcaagactc ttcagagagc aggccttaat actttgatgg gtattggaac
     2101 tgtattcgta atgctgattt tattaagcct tctgatttct ctgttcagat ttattccgaa
     2161 tccggaagca aagaaagcag cagaagcaaa agcagccaaa gctgcaaaag aggcagaggc
     2221 agcagccatc gcacagacag cacctgcaca ggcagaagag aaccttgcag atgacggaga
     2281 gctggtagct gttatcgcag cagccatcgc agcagcagaa ggaactacaa cagacggctt
     2341 cgtagttcgt tccatccgta aagtaaaaag aaatagaaga taattgtcat ttatttagga
     2401 ggattttaaa atgaaaagct atacaattac agtaaatggt acagcatatg aagtaactgt
     2461 tgaagaaaca ggaagcgtat ccgctcctgc agcagctcca aaagcagcac ctaaggctgc
     2521 acctgcagca gctccgaaag cagcagctcc tgcagcaggc gccggcgcag taaaagtaac
     2581 tgcttccgta cctggcaaag ttgtcaaagt agcagcaagc gttggacagg cagtaaaagc
     2641 cggagacagc gtagttattc ttgaatccat gaaaatggaa atccctgtag tagctcctca
     2701 ggatggtact atcgcaagca ttgatgttgc agaaggtgcc tctgtagaaa acggagatac
     2761 tttagcaaca atgaactaag acgggaggta gtcaaatgtc ttatgtaaca gaaacattgt
     2821 ccaacctgat tcatcagaca gcattcttca gtttgacatg gggcaattac ctgatgatcg
     2881 cagtagcctg cgtattcctt taccttgcta tcaagaaggg attcgagccg cttctgcttg
     2941 ttcctatcgc attcggtatg ctgcttgtaa atatctatcc ggacattatg gcaaacccgg
     3001 aagatatgtc taatggtgta ggtggacttc ttcattattt ctacatcctt gatgagtgga
     3061 gtatcttacc atccctgatc ttcatgggtg taggtgccat gacagacttc ggtccgctga
     3121 ttgcaaaccc gatcagcttc ctgatgggtg ctgcagcaca gcttggtatc tatgcagctt
     3181 acttccttgc aatcttcctt ggattcaacg gaaaagcagc ggcagctatc tccatcatcg
     3241 gtggtgctga tggcccgact tccattttcc ttgcaggtaa acttggacag tctgcactga
     3301 tgggaccgat cgcagtggca gcatattcct atatgtcact ggttccgatc atccagccgc
     3361 ctatcatgaa actctgcaca acagagaaag aacgtaagat caaaatggat cagcttcgcc
     3421 cggtttccaa actggagaag atcctgttcc cgatcgttat cacaatcgtt gtctgcctga
     3481 ttttgcctac aacagctccg ctggttggta tgctcatgct tggtaacctg ttcagagagt
     3541 gcggtgttgt aaaacagctg acagaaacag cttccaatgc cctgatgtat atcgtagtta
     3601 tccttctggg tacatccgta ggtgcttcca caagtgcaga agcattctta aacgcagata
     3661 ctctgaagat cgtagtttta ggtcttgttg cattcgcaat cggtacattc ggcggatgta
     3721 tgcttggtaa actgctctgc aaactgactc atggaaagat caacccgctg atcggttccg
     3781 caggtgtatc cgcagtacct atggcagccc gtgtatccca gaaagtgggt gcagaggcag
     3841 atcctacaaa cttccttctg atgcacgcaa tgggcccgaa cgttgccggt gttatcggta
     3901 cagccgtagc agccggaaca ttcatggcta ttttcggagt ataaccaaat caagcaagct
     3961 atcttgcttg tatcaggagg agtgcaactc cttctgataa gctgcggagc agctatttgg
     4021 ttatgagcaa gtagcgaagc ggattgcgaa tatccgatta aacagaacta taaaggagat
     4081 ttaataatgg cagaattaga gaaaaaacct gttaaaattg tggaaaccat tctccgtgat
     4141 gctcatcagt cccagatcgc aacacgtatg accacagaac agatgcttcc gatcgtagat
     4201 aaacttgata aagtcggcta tcacgcagta gagtgctggg gtggtgcaac attcgatgca
     4261 tcccttcgtt tccttcacga agatccatgg gaaagacttc gtaaattacg tgacggcttc
     4321 aaaaacacaa aacttcagat gcttttccgt ggacagaaca tccttggata ccgtccatat
     4381 gcagatgacg ttgtagaata cttcgtacag aaatctgctg caaacggaat cgacatcatc
     4441 cgtatttttg actgcctcaa tgaccttcgt aacctgcaga cagcagtaag cgctgcaaac
     4501 aaagagaagg ctcatgcaca ggtagctctt tcctatacat taggagatgc ttacacactg
     4561 gaatactgga cagacattgc aaaacgtatt gaagatatgg gcgctgattc catctgtatc
     4621 aaagatatgg caggtcttct ccttccaaac aaagctacag agcttgtaac agcattaaaa
     4681 gaaacagtta agatcccgat cgaccttcat acacattaca cctcaggtgt agcttccatg
     4741 acttacttaa aagcagtaga agcaggtgtg gatatcatcg atacagcaat gtctccattt
     4801 gcactgggaa catcccagcc tgcaacagag gttatggttg agacattcaa ggatacacca
     4861 tacgacacag gatttgatca gaagcttctc tccgagatcg ctgactactt ccgtccgatc
     4921 cgtgacgaag ctcttgacag cggactgctc aatcctaaga accttggtgt taacatcaag
     4981 actttactgt accaggtacc gggcggtatg ctctccaacc tgacttccca gctgaaagaa
     5041 cagcacgcag aagacaaatt ctacgatgtt ctcgaggaag ttccgcgtgt acgtaaagac
     5101 cttggtgaac cgccacttgt tactccgtct tcacagatcg ttggtacaca ggctgtattc
     5161 aacgtactta tgggcgagag atacaaaatg gttacaaaag aaacaaaaga tatcctgtta
     5221 ggaaaatacg gcgcaactgt aaaaccgttt aatccggaag tacagaagaa gtgcatcggc
     5281 gatgagaaac cgatcacatg ccgtcctgca gaccttcttg acaacgagct tgagaaactt
     5341 gagagcgaaa tggctcagta caaggaacag gatgaagacg tattaacata cgcactgttc
     5401 ccacaggtag ctatggactt cttcaaatac cgtcaggctc agaaaacaaa agttgacgag
     5461 aaagcagctg acaaaaagaa cggagcatat cctgtataat tgatcagtaa ttaaatatgt
     5521 ccaaacgaaa aaaggagctt gcgtaagcag gctcctttgc gttattatga aagaatatga
     5581 tacccgggaa tataatgtgc caatgggtat atgctgccag tggtacatat ctatattgat
     5641 cgtagcgaag cggagacgtg gaactatgat gaaatagaca atctgcaggg taaaataaat
     5701 acaggagaat attccatgag caaagttata ataatcggcg gcggagccgc cggaatgatg
     5761 gcaggggttt ttgcagcccg taaccatcat gaagttcata tattagagaa gaacgagaaa
     5821 ctgggaaaga aagtcttcat cacaggaaaa ggcagatgca atgtaacaaa tgcctgcgac
     5881 acagaagaac tctttcctgc aatgatgagc aatcccaagt tcctctacag cagtttctat
     5941 tcatttaccc ctcaggatgt aatggagttc tttgagaaag cgggtgtccc tctgaaggta
     6001 gagcgtggaa accgcgtatt tccacagtct gaccattcct cagacatcat ccgcgctctg
     6061 gagcgtgagc tgaagaaagc aggagcaaag attcatcttc acactgctgt acaggaaatt
     6121 gtaaagaaac ctgtaacgga atctgtaaca gattccgtaa atacccttga atcagaagcc
     6181 gcattaacag aatcaggatc tgatgcagga aaaagcaaaa aaggaaaaaa atcacctgac
     6241 ataccgcagg agaagatcac aggagtcatc cttacagacg gaaccttcat ggaaggagat
     6301 gcagtcatcg tggcaaccgg cggattctct tatcagagca ccggctcaac aggcgatgga
     6361 taccgctttg caagagaact tggattgaag gtcacagaca ttgcaccttc tcttgtccca
     6421 ttaaagacaa aagaagacta tatccctaag cttcagggac tttcccttaa gaatacagga
     6481 cttaccataa agaatggaaa gaaagtactc tatgaggatt tcggagagat gatgttcacc
     6541 catttcggag tcacaggtcc catgatcctg tccgccagtg cccacattgg tgcaaaactg
     6601 gcgaaagcac caaacggcga actgtctgca tatctggatc tgaagccggc acttaccaga
     6661 gaacagctgg atgccaggat cctgcgcgaa tttgaagcag gaccaaacaa acagttcaag
     6721 aacgtgattg gcgtactttt cccgtcatct ctgactccgg taatgctgga actgggtgga
     6781 atccccgcag agaagaaaat ccacgatatc tccagagaag aacgccagca cttcattgac
     6841 cttatcaaag ccttcccctt cacaatcaca ggaatgggtg agttcaaaga agccatcatt
     6901 accagaggcg gcgtctctgt caaagagatc aatcccggaa caatggaatc aaagaaaatc
     6961 tcaggtcttt acttcgcagg cgaggtactg gatctggatg cagtgacagg tggatataac
     7021 ttacagattg cctggtctac cgcatatctg gcagcacagg ccatacagta agttgcttac
     7081 tatagaaaca acagaaacaa gcagatgatg agtaccgtgt atgcgaatta tatctatgat
     7141 tcggttatga gcaagtagcg aagcggattg cgaatatccg cttgactgat taataaacat
     7201 taataataaa acagagaaaa tctgtttgaa taatagaaac aggaggaacc acgaaaatgg
     7261 gatgtaacat agccatcgac ggacctgcag gagcaggaaa gagcaccatc gcaaagaaag
     7321 tagcgaaaga attatcattt atctatgtag atacaggagc catgtacagg gcaatggctt
     7381 tatatcttct gaaccatggc gtaaacggag aaaatcagga agagatcgag gctgtatgtt
     7441 ccggcgctga catctccatc gaatacaaaa acggagaaca gattgtcatc ctcaacggag
     7501 agaacgtaaa tgctatgatc cgcaccgaac aggtaggaaa catggcatcc aaaagctccg
     7561 caaacccgaa agtcagagcc caccttctga aacttcagag aactctggca gagaaaaacg
     7621 acgtagtcat ggacggcaga gatatcggca caaccatcct tccaaacgca gaagtaaaaa
     7681 tctacctcac agcaagcgca gacaccagag caaaaagaag agcactggaa tatgaacaga
     7741 agggagaatc cttcgacctg gaccagatcc gaaaagacat catcgagcgc gacgaacgcg
     7801 acatgaaccg cgaaatctcc cctctgaaac aggcagagga cgcagtgctc gtagattcct
     7861 cggaaatggg aattgatgat gttgtaaatg cgattcttaa tgtatataag gaaaaagtgc
     7921 agaaataatt taagaaggat tattttatga aagtaaaagt agcagaaaca gcaggcttct
     7981 gcttcggcgt taaacgtgca gtgaacaaag tctacgaact catagacaca gaacagaaac
     8041 ctattttcac tctgggcccg atcatccaca acgaaggcgt agtagcggat ctggaagccc
     8101 gtggcgtcca tgttatcaca gaagcagact tggatttccc ggatgatacc ctgcagaacg
     8161 gaacagtagt catccgctct cacggtgtag gcaaagccat ctacgataag ctgaaagaaa
     8221 aaaacatctc ttatgtagat gtgacctgcc ccttcgttct gaaaatccac aggattgtgg
     8281 aaaaagaaag ccttgcagga aaccacatca tcatcatcgg cgacaaagac caccccgaag
     8341 tacagggcat ctgcggctgg tgtcagggac cgtacacagt gatcaaaaac caggaagaag
     8401 ccgaagcatt tgtaccccca aaaggcaaaa aaataagtat tgtgtcccag acgacattta
     8461 attacaacaa atttaaagat ttagttgaaa ttctttgcaa aaagaggtat gataataatg
     8521 ttttaaatat tctcaatatt ttaaacacta tttgtaatgc taccgaagaa cggcagagag
     8581 aagcaaaaaa catagccgga gaggtagaca ctatgttggt cgtaggtggc cggcatagtt
     8641 ccaatactca aaagctgttt gaaatatgta aaaaggaatg tggaaatact tactatatac
     8701 aaacacctgt agacttggat tctgaaatgt tccaatgcag tagttatgta ggtattacag
     8761 caggggcttc caccccaaac aaaattattg aggaggttca agaacatgtc agaattaagt
     8821 tttgaacaaa tgctggaaga ttccgtaaag actatcagaa atggagagat tgtacagggt
     8881 actgtcatcg atgtaaaaga agatgagatt attctgaata tcggttataa agcagacggt
     8941 attatcacaa agaacgaata ctctaacgat gcaagccttg tactcacaga tgctgttcac
     9001 gttggagaca caatggaagc aaaagttctc aaagtaaacg atggagaagg tcaggttact
     9061 cttacttaca agagactggc agcagagaaa ggcaacaaac gtcttgaaga agcatttgag
     9121 aatcaggaag tattaaaagc tcctgtaact caggtacttg acggcggact ttgtgtaaac
     9181 gtagacgaag caagagtatt cattcctgca agcctcgttt ccgacacata tgagaaagac
     9241 ctttccaaat atgcagatca ggagatcgaa ttcgttatca cagaattcaa tccgagaaga
     9301 cgccgcatca tcggtaaccg taagcagctt cttcttgctg agaaagcaga gaaacagaaa
     9361 gaattaatgg agagaatcca tgttggtgac acagttgaag gaacagttaa gaacgttaca
     9421 gatttcggtg cattcatcga tctgggcgga gcagacggac ttcttcacat ctccgaaatg
     9481 tcctggggca gagtagagaa cccgaagaaa gtattcactg ttggcgataa agttaaagtc
     9541 cttatcaaag agatcaacgg agagaagatc gcactttccc ttaaattccc ggaagcaaat
     9601 ccatggctca cagcagctga ggacttcgct gtaggaaacg tagttaaagg taaagttgca
     9661 cgtatgacag acttcggcgc attcgtagag cttgcacctg gtgtagatgc acttcttcac
     9721 gtatcccaga tttccagaga gcacgttgcc aaacctgcag atgtactgtc aatcggacag
     9781 gagatcgaag ctaaggttgt tgacttcaac ggagaagaca agaagatcag cctgagcatg
     9841 aaagctcttg aggcaccggc tgaggaagct gcagaagaat aataagagat tactcataaa
     9901 agaatactca tgaatattta tcaaccggct ttgtatgaga ttgatcatac ggagccggtt
     9961 gatttttcgg attataaata cggtcagcag ttacaggaaa attataaata acattgccga
    10021 cagaaaatat attcgtttac aggtgatcag gaaggagtaa tagaatgtcc ggaaaaggaa
    10081 tttatgatat acattgccat attgtacccg gggtagacga tggagccaca gacatagaag
    10141 aaacaggaaa attgctccga atggaatatg aacagggtgt aaggacaatt attgcaaccc
    10201 ctcattttcg ctttcgaatg tttgaaacat cagcagagaa ggtaaaagag cagtttaaac
    10261 tggtggagaa agcagcagca gaagtcgctt cggatcttca tgtatatctg gggtgtgaat
    10321 ttcacacaaa tatggagatg atctccatgc tcagagaaaa taaggtcatg acaatggcag
    10381 gctcccgata tgttctcaca gaattttctc ataattcaga agagaattat atacgcgaac
    10441 gtctcagcac actgctgtca gggggatata agccaatcgt ggcgcatata gaacgttatg
    10501 aggccacacg caccaatatg gattttgtgg aagaactggt agatatgggt gtctgtatgc
    10561 agatcaatgc agacagcatc acaggaaaaa ttgcagaacc atcgtctgcg acttttatat
    10621 cttcaagcca ggggtatctg gttccgaaaa tatcgctgca ttgtatttta ccgagaagag
    10681 ttccgtcttt tgaccagaag tagagtattc tggcatttcc atctgttgca atatatccgt
    10741 ttgctgtctc tgctactcca gtgatgtagc caaaagaagc agaatcatcg gatggatcac
    10801 gaccaagaag caactgctgg tttccatcct gatcatatac tgctatttta tatggggcat
    10861 catctccgac aagacatccg tataccataa tatgttcatt tccgatctca atcagactga
    10921 cttgtttaaa aataccggtt cgtacttcgt catcatccat tgaggttaag atccagggtt
    10981 ctttgagtat gttgccatcc tggaatgtta ttttctccgt atcattgcta taggaatagg
    11041 ccagtcccca cgctccggac ggatgcatgg tcaggttgcc gcttatgtca tgctttgctg
    11101 tggtttgttc atcttttatg acgattcctt tttttgctga gagagaaaca taaagttttc
    11161 cattagtatc tgcagataga tcatttcctt tctcatccat tatatcagag gacagaagat
    11221 tcaggaagtt tcctgtatat tcataagttt ccagagtgtt atatagctga tgatacatcc
    11281 ggtctccgga cagtgcaaat cggtgataca tgatctcaaa tccggcctgg gaaacattaa
    11341 atggaatata ctctgcttca attgcgaaaa gcaatcagca gtgggtgggg acttgcttgt
    11401 atcaggagga gtgcaagctc cttctgataa actgcggagc agttattcgg tgtagagccg
    11461 cgtagcgaag cggattgcga atatccgctt gacaatagga atgaggagaa aaaatggaag
    11521 cgttacaaga aaagaagtag aggatttgat tggcgtagga acaacgaaag catcaaatag
    11581 aatagatttc tgcacaatta tacttatttc tgtatctccc aaatgcggag atacaggagt
    11641 aatttacagg atcgcttcct tatccatctg gcagcgttta tccaggtggc ggttgatcag
    11701 aagcaagaat acaactgttg agaggacaga agagattccg tcagcaacag gttctgcgaa
    11761 aaaagccgct tttgcaccaa agaaagaggg caagacagct gcactgatca caaaaagaga
    11821 ttttctggta acggagagcg caagtcctgt ctttggacat tccagggcag tcagcccgtc
    11881 tacaaagaca tactggaagc ttagcggaat gatcatcagt gtataggtac ggatggtcca
    11941 gacagagaat ctgatatact gtggatcagt ggtaaacaga agaacaaagt accggggaat
    12001 gaaccgggag agaaggaaca tgatggtggt aaagataagc attactccta gaatgttcct
    12061 ttctgcgtct ttgaccctgt ttacgcatct ggcaccgtaa ttgtagctca agattgcctg
    12121 tgtacctccg ctgatcccga tcataggtga ggtgatcaga agcagatagc tttgagcaat
    12181 ggtggcacag gtgatcagta tatcgccctg ggaagcacca ccatatttct ggagcactgt
    12241 attcataaag atcagtatca ggctgtctgt ggccaggatc agaaaaggag aaaatcccag
    12301 ggaaaggatt ttttttatga cttttaagtt gtattgtccg aaggtaatct ttacaggaac
    12361 cttttttcct aacaggaagg tcattgcaaa gatgcaggag agtatctgcg aaataaccgt
    12421 tgcaatggca gcgccggaaa ttcccatatg aaaaccaaaa ataaaaatcg ggtctaacag
    12481 gatgttacat cctgcgccga tcagtacggt aaacattcct acaaggggga agccctgaca
    12541 gttgataaag taattaagcc ctgtagccat cagtgcgaaa aaggtacttg ttgtataaat
    12601 ggtcagatag gtattggcaa agggaaaagt agccccactt gcgccaaacc acataagcag
    12661 cttatctttt agaagaagaa agctgatagt cagcagaaca gaaaaaatac tgagcaccag
    12721 aaaagaattc gccagtacct gttctgcttt tttatgattt ttttctccca ttcggattcc
    12781 catggtaatg gaacctccga ttcctaccag agtgccaaaa gaagtgagaa atgtaacgat
    12841 aggaccgcat acccctgcac ctgcaagagc cagtgcacca ttttgggaaa tatgtccgat
    12901 atacatcctg tcaataatgc tgtaaagtac attgacaaat tgcgcggtca tagaagggat
    12961 ggcaagctgg agcaccagag tgcgtacggg tgccttgcca agatttgctg ttgtgttcat
    13021 tttaattttc ctcatccatt cgacagggac tgccgcatct gtatgtgcag cagcccctgt
    13081 tattaatcat tgtcaattct aacagatatg gacagaaaaa gctataatat ttgagataaa
    13141 aaagacataa aaacctgcta acaaaagtta tgcggtcttc tgtacagcca gagctttgat
    13201 ttcttctaaa tagcctctcg gggtcagacc ccatgaagaa gaaatgattt ttctctaaag
    13261 aaactataaa cgaaaacgag agcataggct actggcgctg ctctaataac tacataaaat
    13321 tttgtggaag gcacattggg cgctacaagg tatggaaagg agaattatga aaacaacatt
    13381 acttatcatg gcagctggta ttggcagccg cttcggaaca ggaatcaagc agttagagcc
    13441 ggtggattat gctttccagg acattaacga tattccgggg actctgccgg aaggccgtac
    13501 aaagccgtgg ggaactggtc aggccgtgct tgcagcgaag aaggtcatca agaccccgtt
    13561 catcgtcatc aatgcagatg attactatgg caaagaaggt ttcaaggctg ttcatgagta
    13621 tctggtgaat ggcggcaagt cctgtatggc aggttttgtg ctgaagaaca cgctgtctga
    13681 taacggtggc gtgactcgcg gtatctgcaa gatggatgag gattacaacc tgaccgaggt
    13741 cgtggaaacg aagaacattg taaagaccgc agctgtagca gaggcagaag gaatggctgt
    13801 tgatgttgat tctctggttt ccatgaatat gtggggctta actcctgatt tccttacaac
    13861 gctggaagag ggattcaaag aattcttcga gaaggaagtg ccgggtaatc cactaaaggc
    13921 agaatatctg attcctatct tcatcggtga actgctggag catgggaaga tatctgtgaa
    13981 ggttctgaaa acaaatgata catggtatca gaaattcaaa gagagcgtgt tctttcggaa
    14041 gttgtttctg ttgttttttg tgacttcgat gattttattc cgaacactat tgaaccgtaa
    14101 tttgtggatg aatccgttat ccaaggtcat gggtggctgg ggcatctggg agacagtgaa
    14161 cggcgagcag aaacttacaa ctgagtgcat agagaatgtg atcataatgg tgccgtttag
    14221 ttcggtagtg atgtggacat tcaaagaaaa gacaggaaac ggctggaaga agatactgtg
    14281 gtatagcggg aagatagcgt tcatcttttc ggtaagcatt gagatgttgc aattattgct
    14341 tagattgggt acgtttcagc tatcggatat cttctacaat acagtaggtg gaatgctcgg
    14401 tggtttggtg tactatgtga caatgaaggc aagaaagcat ctgtagtatg tggggtcaga
    14461 ccccatgaag ataagaagat taaaaattat tgtgtcctgc ctctataaac agtcgtttaa
    14521 atgaaataga tacgaataca gaaaggataa gtgtaatagt tattacatat ggtataagat
    14581 gggaaaaatt aatgaaaatt acgtatataa agaacctgaa gaaataacaa ttcagcgaaa
    14641 caaaatacat aaaaatcaaa gaaatataga agattttata gaattaattg aagaaaatag
    14701 ccaggagatg aaaattcaga agttgatcaa agaagattta tcatttatgg cagattatct
    14761 ggcggagccg tatgaggaat atatctgctt ttctaattat cctattggag ataaaattgc
    14821 agattttgta gtgctgacat caagatcaaa aatgaaagtc tgcattgtgg aagtcaaagg
    14881 tgcagatttt aaaactgtta aggccaatca ctatcagggt ttaaatgtac atatgaatga
    14941 tgcaattaca caactaaaaa atcatatgga atacataaac agaaattaca gttcattcag
    15001 aacccagata catgaagata aggataaagc aatcaatgag gaatatagtg gaaattattt
    15061 agtgggtcct cgaaaaaacc tattggttga cccacagaag gatatagatg ttaaatatat
    15121 agctataggt ggagttgaaa gagaagacaa gtcaattgaa gaaagccacg aaattgtaaa
    15181 atgtaaacca gcagataatt tagagatagc ttcgtggaat tcttttgtgc gtaagttgga
    15241 tgaatatcat ggacatcatc ctgttcaata aaaaacgctg gacagattac cggaaatcat
    15301 ctaaggaaaa aatctcattg taacaggcac gcatcaaatc cacaaatctg gattacctga
    15361 ataaactgac caagagaaag taaaatatgt gcggatacag tccttgtaat aggggtgtat
    15421 tgatgttaag atggtagtat agaagatgtg gataagctga gaaaagaagg tgttaccaat
    15481 gaatgaggaa gaaagattt
//
