LOCUS       c00068_gnlPro..        13557 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGNLHMDI_68.
ACCESSION   c00068_gnlPro..
VERSION     c00068_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:24:49
            Original ID  :: gnl|Prokka|CGNLHMDI_68
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 10110
            Orig. end    :: 23667
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13557
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[20110:23338]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13557
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13557
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             395..1144
                     /locus_tag="ctg68_11"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVHVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             1353..2687
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Btheta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_12"
                     /sec_met_domain="CT_Btheta (E-value: 1.6e-67, bitscore:
                     218.6, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLEDFKMSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFA
                     KSGEGFAEVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVG
                     FYDSVGGRLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIM
                     SKDAQLSLSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSF
                     EEAPAEDGCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGKELGCKS
                     ANKVAKFVRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSG
                     YVALAGTGANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLS
                     AYNAAQNGYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             2726..3091
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_13"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.8e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPAAAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             3122..4525
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_14"
                     /sec_met_domain="HMGL-like (E-value: 1.6e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4.1e-55, bitscore:
                     177.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPAFQKKIIGDKKI
                     IKGRPADQLKPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             4720..6057
                     /locus_tag="ctg68_15"
                     /transl_table=11
                     /translation="MKKFLTALIAFVMCFSVVTTAFAATPDEASDSDLISNIKQAMLDT
                     YYGDEKPEYLNVEILLDDEDEVYFSFSDSFATSANRVYTEAGNYIVSYLENCPVALYKN
                     NRVYMIPDAYNSGVIDDDTLEGLTYCGHMDIVPKSDDSALVIEIKNKVIEECFDGKSPE
                     TLRIDIVGRTSDGGVYYRHEYGFALGVIIEEKFGDCTYSYTHGNDVMLYKNNSVYSIKN
                     AYESGIIDDKIVNELVKMNIGIIPDKDVSTLKQLTLKMCQNAGYTDLAEDDIDIWRIIY
                     LSDDRIMFTFNVSGADIPESPVKEVIGNYTFIGERQLYIYADGQIYTLKEAFDAGIIDN
                     DDLAFFADDWKDDISFSIVLNPTQPDTTAPTTSTTTPDEPATSPAATSATKPVSTSDTA
                     TNDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNHFE"
     CDS             6251..7264
                     /locus_tag="ctg68_16"
                     /transl_table=11
                     /translation="MKKLLTALIAFVMCFSVVTTAFAATPDETSDPDLISDIKQAMLDT
                     YYGDEKPDFIEVRIYGTASDGGVYFDFMDSFTHWTDEVEFDIGDYTVSYPRDCPVLLYK
                     NNKVYTLSDAYETGVIDDDMLYELYVWGNLWGKIDVTPKGEDRALLSEIKRVIINKYYN
                     GKAPEYLNVEIVGSTSDKTVCFRNIPFMSLGVMIEQTIGDYTYYYNHGDDVMLYKNGNV
                     YSIKEAYESGVIDDSILEELSKMNFGLESNKPNTTVPTEPTTSVATVDEPVTVPDTTSA
                     TKPVSTSDTATNDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNYFK"
     CDS             7461..9602
                     /locus_tag="ctg68_17"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVVVSAVSANAVEPLNTPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGKSVKYIAAPEISKLENVNGGVKITWNKVNGASKYRI
                     YHKNSSDWFRVSDTTSNSIVDKSVGMGTYTYTVRCISDDGKSFESGFNPKGSSIRYIQA
                     PKILETNVVNGGIKVIWDSEENTNYRLYCKTEGKGWTKVCDSKTGVVTHKNLQPNKTYT
                     YTVRAISSDAKKYLSGYDPVGMSAKYVATPKISKTEVTYDGVKLTWNKVAGAEKYRVYY
                     KDGEGWNKLADTTGNSYLDMGLVSRELSIKDNSVNGQYIYTVRCISSNGKVFQSGYDTK
                     GSKANLGNECPEIVRVDSMHGGITVSWTDVCEDNSKYRIYVKEKGSWKKLADTTNNYYT
                     HKNVKAGQTYTYTVRCVSKDGKKFTSIYNPSGVTFKYKTTDKTRDAYIDYLLKHESEWL
                     PELKVGNVALAGVQFADLDFDGVPELIVQEAGDKEYYLNAKVYTFKDGKFSLVGFDDYR
                     TYIPNQLTYFYDKSAKKYIINAVELSTSNVDRYLERENYTLNYDGTVLVVRGYSSAHLA
                     LESRGLEYHYYNNTGRTTKQAYNATNVSVLGNCVNAHMYSQFVYCSVDGYPKLWNNYSE
                     TQKKQHLLDSYNAFSYDKY"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_18"
                     /sec_met_domain="IlvN (E-value: 1.3e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1e-60, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_19"
                     /sec_met_domain="ALS_ss_C (E-value: 7.1e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_20"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.6e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKIYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(13425..13556)
                     /locus_tag="ctg68_21"
                     /transl_table=11
                     /translation="TIGGISRIGKDNLMILMSPDNADKKSDLNSRIYFTKLSDLNFQ"
ORIGIN
        1 atttctcttt atgattacgc ttttgaaaag tacaggggag ttgactgcaa ggacgctgac
       61 ttttgtgccg atattccgtg cgtgggcggt gataaggaca gcgtaacggt tacaggtgag
      121 aagaacaaca caatcgtttt aaagcgtgag gactgcgata aaatcaagaa aaaaatcttc
      181 atagacagct ttttgtatgc tccgattgaa aagaacgaat cggtcggcag aattgaatac
      241 acactcggcg gaaagctgct ttataaatgc aacattgttg caggcgaaaa gattaaatcg
      301 gataaaaaga gtgtgtcaat attttcggca ataggaaatc tgttttcgtg acagcttaaa
      361 tatacagaaa attttaataa aaaggaattt acatatggct aaaattgaac ctataagact
      421 tcagaaattc atagcgcaat gcggtattgc gtcaaggcga aaggccgagg agcttattct
      481 cggcggtcat gtcaaggtga acggcaaaac cgcaattctc ggcgataagg ttcttcctac
      541 agacaaggtg tttgtaagag gcaagaggat tgttgtgccg aagggcggta attaccgata
      601 tattatgctc aacaagcccc gtggattcat taccacaatg aatgatgagc gtggcagaaa
      661 gtgtgttgca cagcttgttg agaatgtcgg cgagcgagtt tatccgatag gcagacttga
      721 caaagacagc gagggtatgc ttgtttttac aaatgacggt gactttgcaa acaaggttat
      781 gcacccgaaa aacaatgttt acaagattta cagagtaacc gttcgaccgt caattgacga
      841 ggatcagctt gtaaagcttg aaacaggcgt tgagcttgac ggcaggaaaa ccgctcctgc
      901 atatgtccat gtaattcaca aggagcaggg cagagtagtt cttgaaatga ttcttcacga
      961 gggtaagaac cgtgaaatca gaagaatgtg cgaggctgtc gggcttgagg ttgcaagact
     1021 caaacgcacc cagatcggcg gagttaaaat gggtatgctc aaacagggcg actggagaga
     1081 tttgaccgaa caagaggtta aaaaactgct tgcaaacccg tttttaaacg gcaaacagct
     1141 ttaattttct gtttttgaaa aatacttccg aaacggtcaa taaaactatt cgttaatttg
     1201 acaataaatt tacggttttc acggaataac tattaaatgt gttaaaaatt gaaatagtac
     1261 agcgtgtttt tcttgtactt ttgaagatta tagagtataa tgtatgtgta gaaaattagt
     1321 atgcacgctc agttttcgtg catattcaat acatggtatt ggaggatttt aagatgagta
     1381 ttgaaaagat caatcaggca aaggctgaaa ttgccgcaac ttccgcttat aagacaatta
     1441 cggcgttttt tgatgcagac agcttttgtg aaattgatgc ctttgcaaaa tccggtgaag
     1501 gttttgccga ggttgttgca ggctttggaa cagtagaagg tatgcctgtt tatgcgtttg
     1561 cacagaacag cgacatttgc ggcggtgcca tgagtaaggc acaggctgcc aagcttaaaa
     1621 agctgtatgg tcttgcactc aagacaggcg ctcctgttgt aggcttctat gacagcgttg
     1681 gcggcagact taatcagggt acagagcttc tcgcaggttg cggtgatgtt ctcaatgcgg
     1741 ctgcgtcact ttccggtgtt gtaccgcaga tctcggttgt tctcggcact tgcctcggaa
     1801 caaacgctct taacgccgca agcgcagaca tcgttatcat gagcaaagac gcacagcttt
     1861 cactttcggt aacaggcaag cattcagatg ccgcttacaa tgctgaaaac ggtattgcct
     1921 caatcgtttg tgacgatgca gacaaggcaa tcaaggctgc aaaggaactt atcctttatc
     1981 ttccgtcaaa taaccttaca atggctcctc agtcatttga agaagctccg gcagaggacg
     2041 gttgcggttg tgtagtcagc agaacagttg acggcaacag cattgtaaag ctcttcaatg
     2101 attacggcaa ggaagcaaat gttcgttttg caagactcgg cggtcaggtt gtaggtattg
     2161 ttgttacaaa gggcaaggag cttggttgca agtctgcaaa caaggtagca aagtttgttc
     2221 gtttctgcga cgctttctca ctccctgttg taacattcgt aaactgcccg ggctttgagt
     2281 caatcaagtc ggcaacaaag gcatcagccg cttatgctga ggcaacaaca gttaagattt
     2341 ctgttgttac aggcaaggca atcggttcag gctatgttgc tcttgcaggc acaggcgcta
     2401 atgcagatgt tgtttacgca cttcccgatg cagttatttc acctgttaat gttgaggctg
     2461 ccgcattcat tatggctccc gaagttatga atgttgccac agataagcag gctgaggttg
     2521 ctcagaagtt tgctgacgag aatctttctg cttacaatgc cgctcagaac ggctatgttg
     2581 acggtattgt tgaagaagct cagctccgtc agactcttat ttctgctctt gatatgctct
     2641 cgggcaagcg tgtttcaaca ctttcaaaga agcattcaac tatctgataa atgattactt
     2701 gttaaaataa aaggggatac taaaaatgaa gaatttaaga attacagtta acggcacagc
     2761 atatgatgtt caggttgaag aactcggtgg ttcttcagct cccgcagcag ccgctcctgc
     2821 tccggcagcc gctcccgctc ctgcagcaaa gccggcagct cccgcaggcg ctcagggttc
     2881 tgttgttgta aaggctccta tgcccggtac agttgttaat gttgttgttt cggcaggaca
     2941 ggctgttaag gccggagatg acctcgtatt catcgaggct atgaagatgg aaactcccgt
     3001 taaggctccg caggacggca cagttgcaac agttgatgtt gcaaagggtg agtcagttga
     3061 ctcaggtaag gttctcgtaa cacttaacta atcaataatt cggagaaagg gatgctgtaa
     3121 aatggcaaaa aaaatcagag ttaccgaaac tgctctgcgt gacgctcatc agtcactcat
     3181 tgcaacaaga atgacaacag aggaaatgct ccctgttctt gacaaactcg ataaaatcgg
     3241 ttattactca ctcgaatgct ggggcggtgc aacatatgac tcatgcctca gattcttaaa
     3301 cgaagatccg tgggacagac tccgcacaat tagagagcat tgccctaaca caaagctcca
     3361 gatgcttttc agaggacaga atatgctcgg ttatcgtcac tatgccgatg actgcgttga
     3421 gtaccttgtt cagcgttcaa tcgcaaacgg tattgacatt atccgtattt ttgatgctct
     3481 taacgacatc aagaatctta aaacagctat caaggccgct aacaaagaag gcggtcatgc
     3541 acaggttgct atcagctaca caacaggtcc tgtattcaca gatgaatact atgttgagta
     3601 tgctaagaga attgcagacg caggtgcaga ttcaatctgt atcaaggata tggctgctct
     3661 tcttactccg acaagaaccg aaagtcttgt aaaggctatc aaagccgctg ttccggagct
     3721 tccgcttcag ctccacaccc actacacatc aggtcttgca tcaatgtgtc ttttaaaggg
     3781 tgttgaggca ggtgccgacg gcattgacac agcaatcagc ccactcgctc tcggtacatc
     3841 acacgcacct acagagtcaa tggttgccgc tctttcaggc acagagttcg acacaggtct
     3901 tgaccttaaa cagttctctg acatccgtgc ttacttcatg actctccgtg agaagtacat
     3961 caagtcagga cttcttgatc ctaagatgct cgcaacagac gctaacgctc ttatctatca
     4021 ggttcccggc ggtatgcttt ccaaccttct ttcacagctc aagcaggcag gtaaggaaga
     4081 caagcttgac gaagttcttg cagaagtacc ccgtgttcgt aaggattcag gttatcctcc
     4141 gcttgttact ccgacatcac agattgtcgg cacacaggct gtattcaatg taatcacagg
     4201 caagcgctac tcaatgtgca caaacgagtt caagggactt gttgccggtg agtatggtac
     4261 aactccaatg ccgattgatc ctgcgtttca gaagaagatt atcggtgaca agaagattat
     4321 caaaggtcgt cctgcagatc agcttaagcc tgagcttgat aagctccgtg gcgagattga
     4381 gcagtggatt gaacagcctg aggatgttct ttcttatgca cagttcccga aggttgccct
     4441 cgacttcttt gaaaagagaa gaaatgccaa ggttggcatc aacggcgaca agcttgacaa
     4501 gaaaaatatg gttcacccag tttgatttga caactaaaat taacatttat gccactttcg
     4561 ctatgaaagt ggcattttca tttgggcaga attattcttg ctaaattttt agcaactata
     4621 ttgcattaca tatattttag cggtataatg atgtaaattg aatatctgtt gcatatacca
     4681 ttattacaga tagaataaat aaaagatgag gaaataaaaa tgaaaaaatt tttaacagca
     4741 ttgatagcat ttgtaatgtg cttttcggtt gtaacaacag cttttgcggc tacaccggat
     4801 gaagcttctg attcagactt gatttcaaat attaaacagg ctatgttaga tacatattat
     4861 ggtgatgaaa agcctgaata tctgaatgtc gaaattcttt tggacgatga agacgaggtt
     4921 tatttcagtt tttctgacag ctttgctact tctgcaaaca gagtttacac cgaggcaggc
     4981 aattacatag tttcttacct tgaaaattgt cctgtggcac tgtacaaaaa caacagggtt
     5041 tatatgatcc ccgatgctta taattcaggc gttattgatg acgatacact tgagggcttg
     5101 acctattgcg gacatatgga tatagttccg aaaagcgatg attcagcact tgttatcgaa
     5161 ataaaaaaca aagttattga agagtgtttt gacggcaaat cacctgaaac tttgagaatt
     5221 gatattgttg gcagaacaag tgacggcgga gtatattata gacatgaata cggctttgca
     5281 cttggtgtta taattgaaga aaaatttggt gattgtacat atagttatac acacggaaac
     5341 gatgttatgc tctataagaa taacagtgtt tattcaatta aaaatgcgta tgagagcgga
     5401 atcattgatg ataaaattgt caatgagtta gtaaaaatga atattggtat tattcctgat
     5461 aaagatgtaa gtacacttaa gcagttaacc ctgaaaatgt gtcaaaatgc aggttatact
     5521 gatttggcgg aagatgatat tgatatatgg agaattatct atttaagtga tgaccgaata
     5581 atgttcactt ttaatgtatc cggtgctgat attcccgaga gtcctgtaaa agaggttatc
     5641 ggaaactata catttatagg cgagcgacag ttgtatattt atgctgacgg tcaaatttac
     5701 acattaaaag aagcttttga tgcgggcata attgataatg atgacttggc attctttgct
     5761 gatgattgga aagatgatat ttctttcagt attgtcctta atccgacaca gcctgataca
     5821 acagctccga caacatcaac gacaacacct gatgaacctg ctacatcacc tgccgcaact
     5881 tcggcaacta agcctgtttc aacaagcgac acagctacaa atgacacacc gaacaattca
     5941 cagaacaaca gcggtgctgt acagacagga cagaacagcg ttgctgtaat tcttcttgtt
     6001 gcaatgcttg caggttgtgc agtaattttt gcaaaacgca gaaatcattt tgagtaattt
     6061 acaaattaaa taatccctat aaaagccgtt ctcgttattg agagcggttt ttattttgct
     6121 gattatttta tgtgaatttt tagcaactat attgcattac atatatttta gcggtataat
     6181 gatgtaaatt gaatatctgt tgcgtatacc attattacag atagaataaa taaaagatga
     6241 ggaaataaaa atgaaaaaac ttttaactgc attgatagca tttgtaatgt gcttttcggt
     6301 tgtaacaaca gcttttgctg ctacacctga tgaaacttct gatccagact tgatttcaga
     6361 tattaaacag gctatgttag atacatatta tggcgatgaa aagcctgatt ttattgaagt
     6421 aagaatatat ggtacagcca gtgacggtgg cgtgtatttc gattttatgg atagttttac
     6481 acactggaca gatgaagtgg aattcgatat aggtgattat actgtttctt atccgagaga
     6541 ttgtcccgtt ttgttataca agaataataa agtatatacc ttgtcagatg cctatgaaac
     6601 aggtgtaatt gatgatgata tgctctatga attatatgtt tggggaaatc tttggggtaa
     6661 gatagatgtt accccaaagg gtgaagatag agctctcctt tcagaaataa agcgtgtaat
     6721 tataaataaa tattacaatg gcaaagcacc tgaatatttg aatgtcgaaa ttgttggttc
     6781 tacaagtgat aaaacagtat gttttagaaa tatacccttt atgagtttag gcgttatgat
     6841 tgaacaaaca attggtgact atacttatta ttacaaccat ggcgatgatg ttatgcttta
     6901 taagaatggc aatgtttact caattaaaga ggcttatgaa agcggagtta ttgacgatag
     6961 tattcttgaa gaattgtcaa aaatgaattt tggtttggaa tctaataaac cgaatacaac
     7021 tgttcctact gagcctacaa cttcggttgc aacagttgac gaacctgtaa cagtacccga
     7081 tacaacttcg gcaactaagc ctgtttcaac aagcgacaca gctacaaatg acacaccgaa
     7141 caattcacag aataacagcg gtgctgtaca gacaggacag aacagcgttg ctgtaattct
     7201 tcttgttgca atgcttgcag gttgtgcagt aatttttgca aaacgcagaa attattttaa
     7261 ataattcaaa acatcaacag aatatataaa ataaaccgtt ctcgctttgg tgaacggttt
     7321 atttatttta gcttaaaaat ttgtgatagt ttatcaagat gtattgcttt ttatatcatt
     7381 taatgttaca attaacttgc ataaaaattt agcaaaagtt cttaataatg cgtagaatat
     7441 ttacaaagtg agggataact atgaaaaagt ttttacctat agccatggcg gcggtaatgt
     7501 cgatgtctgc ggttgtggtt tcggcagttt ctgcaaatgc ggttgaaccg cttaacacac
     7561 ccgtgcagta tgcacaggtt gcaagggcaa gcttggcaac tccgaaaatt tcaaaagccg
     7621 aaagcgttta cggtggtgta aagcttacat ggaacaaagt gaatggtgcg gctaaataca
     7681 gagtttacta caagggccgt aaaggttgga cacgaatggt cgatacaact tcaacctcat
     7741 atatcgacaa ggatgtttca tcgggcagga attacaccta tactgtaaga tgtatttctg
     7801 ctgacggaaa gagctttaca agcggttatg attcaaaggg caaaagtgta aaatatattg
     7861 ccgcccccga aatttcaaag cttgaaaatg taaacggcgg tgtgaaaatt acatggaaca
     7921 aagtaaacgg tgcatcaaag tatagaattt atcataaaaa ttcgtcagat tggttcagag
     7981 tatcagatac gacttctaat tctatagttg ataaatctgt tggtatggga acctatactt
     8041 ataccgtgag gtgtataagt gatgacggaa agagttttga gagtggattt aacccaaaag
     8101 gctcaagtat cagatatatt caagctccta aaatacttga aaccaatgtt gtaaacggcg
     8161 gtattaaggt gatttgggat tctgaagaaa atacaaatta cagattgtac tgcaaaacag
     8221 aaggtaaggg ctggacaaaa gtatgcgata gcaaaacagg tgttgtgaca cataaaaatt
     8281 tacagccgaa taaaacctat acatacactg taagagcaat cagttccgac gctaaaaagt
     8341 atttgagcgg ttatgaccct gtgggaatga gcgcaaaata tgttgccaca ccgaaaattt
     8401 caaaaactga ggtcacatat gacggcgtaa agctgacatg gaacaaggtt gcaggtgcag
     8461 agaagtaccg tgtgtactac aaagacggtg agggttggaa caaacttgcc gatacaacgg
     8521 gtaacagtta tcttgatatg ggacttgtat caagagaact aagcataaaa gataattccg
     8581 taaacggtca gtatatttat actgttcgtt gcatttcaag taacggcaag gtttttcaga
     8641 gcggttatga tacaaaaggt tctaaggcga atttaggcaa tgaatgtccg gagattgttc
     8701 gtgttgactc aatgcatggc ggaattacag tttcatggac agatgtttgc gaagataatt
     8761 caaagtatcg tatttatgta aaagaaaaag gttcgtggaa aaagcttgct gatacaacaa
     8821 ataattatta cactcataaa aatgtaaaag caggacagac ctacacttat accgtaagat
     8881 gtgtttctaa ggacggcaag aaatttacaa gtatctataa tccgtcaggt gtgacattta
     8941 agtataagac tacagataaa acaagagatg catacataga ttatctgctc aagcatgaat
     9001 cggaatggtt acctgaactc aaggtaggaa atgttgcttt ggctggtgtg cagtttgccg
     9061 atctcgattt tgacggtgtt cccgagctta tagtacagga ggcaggagat aaggaatact
     9121 atttgaatgc aaaggtgtat acctttaagg acggaaagtt ctcgttagtc ggatttgatg
     9181 attatagaac ttatatcccg aatcaactga cttatttcta tgacaaatct gctaagaaat
     9241 atataattaa tgccgttgaa ttgtcaacct caaatgttga ccgttatctt gaacgcgaaa
     9301 actatacatt gaattatgat ggcacagttt tggttgttcg tggatactct tctgctcatt
     9361 tggctcttga aagtcgggga ttggaatacc attattacaa taataccgga agaacaacaa
     9421 aacaggcata taatgccaca aatgtgagtg tactcggtaa ttgtgtaaat gcacatatgt
     9481 acagtcagtt tgtttactgt tctgttgacg gctatccaaa actttggaat aattatagtg
     9541 aaacacagaa gaaacagcac cttctcgatt catataacgc tttttcttac gacaaatatt
     9601 gattgtcaaa attgataagt tttaactgca aaagggttca gccgcaaaaa gctgaaccct
     9661 tttattgcac aacaaaaaac ggttcagcca aattgactga accgttaatt catactatgt
     9721 taagcttggg aaccagtagt tgtaaattat cacaaactac ctacacaaac tgcgagcgag
     9781 gtactcgcaa aaagggtagc ttgaaagtta taactatgtt aagctcggga ataagtagtt
     9841 gtaaattatc acaaactacc tacacgaact aagagcgagg cactcgcaaa aagggtagct
     9901 tgaaaatcaa gctaccctaa attcgtacta tgtaatgctc gggtgacaga agtttgaata
     9961 catcaaactg tcttcacgaa ctgtgtgcga gacactcgca ttagttgttg atgagcttat
    10021 cttcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cggcagcgag ctttctcata gccttgaagt gaacctgtga accggcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcat ttcttgggtc gtaaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcgcaaa caccgccgca aagaacagcc tgttcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacacctgct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagca tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgacccg
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagca aacataagca tgttgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttgta aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgccgat gtatatacct taaagccctg tgcctcagcc tttgcccagc
    10861 tcttgctgcc tttgtaaaga ccgatgatta catcgcaacc tgaatccttg aggttgagag
    10921 cgtgtgcatg accctggctg ccgtaaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttgca atctgactga tagtagattg gtgctgtcat gttttttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta aaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt cgatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gacgcggctt gcacattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat ttttgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcgcagtg aaccttgatt aaaacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacttt gatgacggga atgagcttgt
    11401 tgagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cgggtcctga gtaacaccta ctgcgagtga gtcgatgtta aaacctcggc
    11521 gagagaaaag tcccgaaatt tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttcc gaatcaacaa tacccttgat gatgttttcg gcttccttgt
    11701 ttgaatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgcg gagtgtctgc caccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tagtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacat
    11941 cacggtcggg tcttgcaaac tttgcaccga ttgcagcggg aattgagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacatcg gcaacgagaa ttgcctttga gcggaacatt gcactgagat
    12121 gaccgacaag tgttctcggc tcaacaaagc cgtcaaatac gggaggttca cggtaaaggt
    12181 cttttttcca gttctttacg gtttcgctcc acattgttgt aaccttgtaa tcgccgatgc
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tctgttttaa
    12301 cattcttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agccgcaaca gctctgtcac cgagtcttgc accgcatacg attacaaggt
    12421 cggcttcgtg aagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaactcagc acgccgccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttagtgttc ggcttgtaac cgataatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc tgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggttgca atgcctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgagtc gtaaatttta tcgtaaaatg
    13141 ggcaaatagc cgcaccggga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct ttttattgtg
    13261 agcaaaaggt gttttgtaac attaaatata cctttttact ttaccgctaa ttatacaata
    13321 aataccttaa aaagtaaaga gcagtattgc ccataaatta aattttttgc aggattttga
    13381 cagataattt gcaaaatgaa ttttaattga tttttaccgc ctgtttactg aaaatttaag
    13441 tcgcttaatt ttgtaaagta tattcttgaa ttaaggtcac tttttttgtc tgcattatca
    13501 ggggacatca atatcatcaa attatctttt cctatccgtg atataccgcc tatagtg
//
