LOCUS       gnlProkkaPFBDDIFG_285  13654 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PFBDDIFG_285.
ACCESSION   gnlProkkaPFBDDIFG_285
VERSION     gnlProkkaPFBDDIFG_285
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 02:53:41
            Original ID  :: gnl|Prokka|PFBDDIFG_285
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13654
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13654
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2065:3654]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2066..3654
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13654
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13654
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             87..1592
                     /locus_tag="ctg285_1"
                     /transl_table=11
                     /translation="MSNNIRIRKNKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDGDNVDKTEGSGKTDPTENADPTETPEISSE
                     KPAADENADTDNKEDKESKSDQDNKTDTGNEENKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGAGDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSVNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVAVFIKKRKK"
     CDS             1642..1992
                     /locus_tag="ctg285_2"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSVMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             2066..2206
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg285_3"
                     /sec_met_domain="TIGR03973 (E-value: 3.5e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 4.5e-28, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             2287..3654
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg285_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 1.7e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.2e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.6e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             3766..6174
                     /locus_tag="ctg285_5"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSERETLQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVFALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             6256..7968
                     /locus_tag="ctg285_6"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYITALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DSQGISVEGIYFGEAEDFVNFIREKDSISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             8116..8640
                     /locus_tag="ctg285_7"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             8678..11008
                     /locus_tag="ctg285_8"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPEVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLLEKIRQVESVIDVERTTG"
     CDS             11073..11702
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163; E-value: 1e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg285_9"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACHQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             11695..13209
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg285_10"
                     /sec_met_domain="PF04055 (E-value: 6.1e-25, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFENRDFEHDVYELIKAFYPEAEIHTLYENAEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 acgtaaaaag agaactgata tttggctgaa agtaaaaaat gattatcagg aaacataaga
       61 atcgaatata aatatagagg tgcgatatgt ccaataatat aagaataaga aaaaataaat
      121 taaaaggaac gggtattttt gcggcagcgg ctttaacagc ggctttgatt gcaggaaata
      181 atataccggg tgtaacaaga caggtcagtg cggctgagtc acaggagaat actgtgtctt
      241 ctctgatccc ggacaacatt acgcttgata agcctgtaga acttgcggat gtagaacttc
      301 cggcaacgga atatggaact tttgaatggg cagatggaag tttcgttcct gcacagcgtg
      361 tacagagctg tgaggtactt cttataccgg cagaagggca ggatttaagc catgtggatg
      421 gatgggatcc ggagagcggc gcggttgtcg gttacatcaa tgtaatagtg aacagtatta
      481 cggatggtga taatgttgat aagacagaag gctcaggtaa aacagatcca acagaaaatg
      541 cagatccaac agaaacgcct gaaatttcgt cagaaaaacc tgccgcagat gaaaacgctg
      601 atacagacaa taaagaagat aaggaaagta aatcagatca ggataataaa actgatacag
      661 gcaatgaaga gaataagatt gaagaagata aaacagataa taaaaacaac aaagataata
      721 acagcaatgc agataagacg gataaagata cagaaactac cggtaagctg gaacctgcag
      781 atgatatgac acaggataaa gaagatacga agaaagatga tgaagatggc gcaggtgata
      841 atatctttga taatcctgtt ctgccggacg ataaggatga ccgtcctaca gatgcagagg
      901 attctctttc tgatgaagaa aaagaagaga gggccgcact taatcatacc tgcgacggta
      961 ttacagtaag cggagttaat cttccatggt atgtacagtt cagagtttca agcggtgaca
     1021 gctatcagtt taccaatgaa tcagatgcaa tgattttcca gtcttatgaa tttgaactct
     1081 gggatcttaa gaataataca gaatacgaga tccctaatgg agattatatc agtgtcactg
     1141 tgccggtaaa atccggatat cagtatacta tcgaacatct cctggataac ggggcaactg
     1201 agacgattat tccgagtgta gagaatggta ttatggtatt cagcacacat tctttcagtc
     1261 catttggaat tgcaggaagc agacaattag taggacctga tgcagggaat gatacggacg
     1321 acacagatgc ggtaactcct gcaccggctt cctccgacag tcagagctct gattccggaa
     1381 agaacaatac agtatctgtg aatgacagtt ctgacagcaa taatggttct tcttctgatc
     1441 agaatgataa ttcaacggaa aataaagctg tgaaaaataa caatacagta aataccggag
     1501 atacaacatc aattatgccg tttgtgatac tgtttgtggc agctgcagtg atcgccggtg
     1561 tggctgtatt tataaaaaag agaaagaaat aaaagaataa cactgattcc tcccccatat
     1621 agtttaacag gaggggaagc aatgaaagtc agagcaattt tgaaatcact attatttgca
     1681 tatgcattaa caggagtggc attactgctt ttggccctgg tactgtttgc ttttgatctg
     1741 ggagaaacag ctgtagatgc gggtattatt ataatttatg tacttgcatg tttcatggga
     1801 ggctttatgg ccggcaaaat tgtgcgtaaa gacaaatatc tgtggggtgt tatcacaggt
     1861 ctggcttact atgtattact gttgactgtc tctgttatgg caaaaggcgg ctgggatatg
     1921 agtgcagctc atgcagttac aacatttttt atgtgcacag gcggcggaac actgggtgga
     1981 atgctgtcgt aaaaaaaagc ttttaaaatg aaaagatata tgatatacta tgccaagaat
     2041 ataattacat aaggaggata gagttatgga acatatcaaa accctgaata caaagaattt
     2101 acagaacact gtaaaaaaag gtggatgtgg cgagtgccag acttcctgcc agtccgcatg
     2161 taaaacttcc tgtacagtag gaaaccagag ctgcgagcag aaataagatc agctatggag
     2221 aaatgagata agcagcggaa cttttattcc gctgcttatc ttacgcttag aaaggatttt
     2281 agtaaaatga gtctgattca ccgttataaa agcaatggct ttaatattgt actggatatc
     2341 aacagtggat gcatccatct ggtagatgag gttacatatg aggttcttcc atatctggaa
     2401 gagggccttg gcacagaagc tattgcagag aaactggaaa acaaatataa cagagaagat
     2461 attgagacat ctgtaagaga atgtaataag ctgaaagaag atggaatgct ttttacaaaa
     2521 gatgtttatg agaatgtaat tgaagaattt tcaaataacc ggcagaccgt tgtaaaagca
     2581 ttgtgcctgc acattgctca tgactgcaat ctggcctgcc gttattgttt tgccgaagaa
     2641 ggcgaatatc atggcagaag agctcttatg tcctatgaag tcggcaaaaa agctcttgat
     2701 ttcctgatcg cgaactccgg ttccaggaaa aacctggaag tagatttctt tggcggcgag
     2761 ccgctgatga actggcaggt tgtaaaagat ctggtaaaat atggcagaga gcaggaaaag
     2821 cttcacaata agaaattccg tttcacttta acgacaaacg gagttcttct gaatgatgaa
     2881 gtaatggaat tctgcaataa agagatgggc aacgttgtac tgagtgtgga cggacgtaag
     2941 gaagtacatg attacatgcg tccattcaga aaaggtgcag gaagctatga cctgatcatg
     3001 ccgaagttcc agaagtttgc agaatccaga aatcaggaca agtattatgt aagaggtact
     3061 tttacccacc ataatcttga tttctccaag gatgtgcttc atctggcaga tcttggattc
     3121 aaacagattt ctgtagagcc tgtagttgcg gctgatacgg aggaatatgc aatccgcgag
     3181 gaggatatcc cccagatcat ggaagagtat gatactcttg caaaagaaat gattaaaaga
     3241 gagaaagagg gaaaaggatt taacttcttc cattttatga tcgaccttac aggtggccct
     3301 tgtgtataca agagactgtc aggctgcggt tcaggaacag agtacctggc tgtaacaccc
     3361 tggggtgatt tttacccatg tcaccagttt gttggtgaag aacagtatct catgggaaat
     3421 gtagacgaag gcatcacaaa gccggaaatc cagaaggaat tcggcggatg caacgtttac
     3481 acaaagaaag actgcaaaga ctgcttcgca cgtttctact gtagtggcgg atgtgcggca
     3541 aatgcattcc atttccaggg agatatcaaa ggcaattatg aaatcggatg cgaactccag
     3601 agaaaacgtg tggagtgcgc catcatgata aaagccgcac tggcatgtga ttagtgggca
     3661 gtaatctgtc tgactgatac cgccgtcggc tgttatcata acagaaaatg gctggcaggc
     3721 ggatgaacat gaccgcggac aaaaaatcaa gaagggaaaa gaactatgaa gaaaagtaaa
     3781 ggaatcgtag tgctgcttct gacactgatc ctgactgtgt tcttttgctt tactgcagcc
     3841 gtaggtatcg gtcctaccgg aaccggtgca gcaaaacata tcaacacggg tcttgatctt
     3901 gccggtggtg tcagcattac ctaccaggct aaggaaagca atccgacaag cgaagagatg
     3961 tcagatacga tctacaagct tcagaagcgt gtagagcagt acagtactga ggctcaggta
     4021 taccaggaag gatcagaccg tattacagtt gaaattcctg gtgttacaga tgcagatact
     4081 attctgaatg atctgggtaa accaggttcc ctgtatttca tcacaaaaga agatgctgac
     4141 ggaaaccaga actttactac aggacaggat ggatatgttc tttccagaac tatggatgag
     4201 atcaaggaat ccggaagtgt tgttctggaa ggttctgatg tagcagatgc ccagggtggt
     4261 gcgatccaga atcagaacac aagtgcaaag gaatatgtgg taagtcttac tcttacttct
     4321 gatggagaaa acagtggtaa aacaaaattt gcagaagcta caaagaataa tgtaggcaag
     4381 cagatcgcta tcgtctatga caataacatt atcagtgctc cgaatgtaaa tgaagagatt
     4441 tccggcggaa aagcacagat cagcggaatg tctgacctgg aagaagcaca gaaccttgct
     4501 tcttatatcc gtatcggttc tctgggactg gaactggaag aacttcgttc cagtgttgta
     4561 gctgcacagc ttggtgaaga agcaatctct acaagtgttc ttgcaggtgc aatcggtctg
     4621 atcatcgtta ttatctttat gatcattgca taccgcgtac ctggtgtagt tgcaggtatc
     4681 gcactgattc tttatacatc attaatgctg atcacgctga atgcctttga tattactctt
     4741 actcttccgg gtattgcggg tattattctt ggtatcggta tggcggtgga tgccaatgtt
     4801 attatttatg cccgaatcag agaggaaatt ggtgcaggag tttcagtaag gaattctatt
     4861 aagtccggtt tcagcaaagc tttctctgca atctttgatg gaaatattac aacactgatc
     4921 gcagcctttg tgctgatgtg gcttggttca ggtactgtta agggatttgc ttatacactt
     4981 gcccttggta tcgtgatctc catgtttaca gcactggttg tatccagact gattgtaaat
     5041 gcactttatg cagttggtgt acgtgatccg aaattctacg gatctgcaaa agaacgtaag
     5101 gcagttgatt tccttggaaa gaagaaagta ttttttgcta tttccattat cctgatcctc
     5161 tgcggtccgg cagcgatgtt tgctaattcg catgcaggaa acaaagcgtt aaattacagc
     5221 cttgagttct caggcggtac ttctacgact gttacattta atgaagatat ggatattaag
     5281 accattgatt ctgaagtaac tcctgttgta gaagaggtga caggagataa aaatgttcag
     5341 cctacaaagg tagtcggaac aaatcaggtt gtgatcaaga cacgttctct gaatcagagc
     5401 gaacgtgaaa ctctgcagag tgcactggtt gagaaatttg gtgtagatga cagcacgatt
     5461 tccacagaaa gtatttcttc tacagtaagt agtgaaatgc gtcgtgatgc gatcgtagcc
     5521 gttatagtag ctacaatctg tatgcttctt tatatctggt tcagatttaa agacatccgt
     5581 tttgcaagca gtgcggtatt tgcgcttctg catgatgttc tggttgtact tgcattctat
     5641 gctattgcca gagtatctgt cggtaataca tttattgcct gcatgcttac aatcgtaggt
     5701 tattctatca atgctacaat cgttattttt gaccgtatac gtgagaacct tcacagtggt
     5761 tccagagaaa aactggcaga aattgtaaac acaagtatca ctcagactct tacaagaagt
     5821 atttatacct cttttacaac ttttgttatg gtagctgttc tttatatcat gggtgtttct
     5881 tctatccgtg aatttgcagc acctctgatg gttggtgttc ttgtcggtgc atattcttct
     5941 gtatgtatta caggtgcgtt gtggtatgtg atgaaaaaga aatttgcagg aaaaggacag
     6001 ccggcaattg ctgcagcttc cgcatctgca aagtcctctt caaagccgaa gaaagcacgt
     6061 gatgtatcac agaaagatcc gactcagcca aagaagaaaa acagaaaaag agtagctgaa
     6121 cgtctggctg ccgaagaagc agctaaaaaa cagcagaatg atgatgctga ataaaacaat
     6181 aattgtctga aaaacaggca gacagaaata tcccggggta aaactccggg atatttctat
     6241 gaggagagaa aatatatgga gaaatgggta atagcagcaa aaagagcaga ttttaaccag
     6301 atcggtcaac agtttcatat tgatccggtg attgcgagac tgatcaggaa cagagatgtg
     6361 atcggagaag ataagataag agagtatctg tcaggaacag tacaagagct tccttctccc
     6421 tggctgatga aggatatgga aaaagctgta gatatcctgg agaaaaaaat atcgcagaaa
     6481 gcaaaagtcc gtattattgg tgattatgat attgatggtg tgacctctac atacatttta
     6541 atgaaaggcc ttgcgaggat cggagcagat gtggatactt atattccgga cagagttgca
     6601 gacggatatg ggattcatgc acatcttata gaaagagcgg aaacggaccg gatcgatacg
     6661 atcgtgacct gtgataatgg aattgctgcg gctgctgaaa tccagatggc aaaggataag
     6721 ggaatgacag tgattattac agatcatcat gaggttcctt acagggagga aaagggagaa
     6781 cgccagatgg tgcttcctcc ggcagatgcg attttgaatc cgaaacaata tgattgtcca
     6841 tacccgaata aaaacctgtg tggagcagtg gtggccttta aatatattac agcactttac
     6901 gagagatttg gtgttccggc agaggagctg gaagattatt atgaactggc ggctattgca
     6961 acagtaggag atgttatgga tcttcaggga gagaacagga ttctggtaaa agaagggctg
     7021 tgccgtctga aaaataccaa aaatcaagga ttgcaggaac tgatccgcgc aaattctctg
     7081 gaagatgcta aaatcacagc ttatcatatc ggatttgtgc tgggaccatg tatcaatgcc
     7141 agtggcagac tggatacagc tgcccgttct cttgcacttc tcaatgcaaa aacaaaggaa
     7201 gaagcagcaa ggcttgccgg agatcttaca gctcttaatc agagccgaaa agctctcact
     7261 gagaaaggaa aagaagaggc aatccggatc atagagacta cagagctgaa aaatgacaga
     7321 gtactggtag tttatcttcc ggattgtcat gaaagtcttg ccggtattat agcaggcagg
     7381 atcagggaaa aatatcacag gcctgccttt gtattgacgg gcggtgagac aagtgcaaaa
     7441 ggaagcggaa gatcaataga aagttactct atgtatgaag aactggtaaa atgtgcagac
     7501 ctgatgatac agtttggagg tcatccgatg gcagcaggtc tttctataga agaaaaaaat
     7561 atagaagaat tccggagacg tctcaatgta aattgtacgt tgacggacga agaattgcgt
     7621 cctaagatcg tgattgatgt gccgatgcct gtgtcttata ttacaaaaga actggtagaa
     7681 cagatttcgc ttttggagcc ctttgggaaa gggaatacaa aaccggtctt tgcgcagaaa
     7741 aatctcagag tgcttgatca cagtattatc gggaaaaata aaaatgtagt aaaattaaaa
     7801 cttctcgatt cgcaggggat ttcagtggaa ggcatttatt tcggagaagc agaggatttt
     7861 gtgaacttta tcagggaaaa agacagtatt tctgttactt attatccgga gatcaacaga
     7921 ttcaggggac gagagagtct tcagatcatt attcagaatt actgttaata ttaccgcctg
     7981 ttttgtaacc gccggtaagc ctggaaatac aaatgtcagg gcttaacagt aacttgattc
     8041 tgaaataaaa aggtgatata ctataaaata tttatgagcg aacagcaata taacacacac
     8101 tggaggagaa ataaaatgaa gaaaattgaa gattatgtat taagtatacc ggattttcct
     8161 gaaccgggga ttattttcag agatattaca agtgttctgc aggatgcgga tggcctgcag
     8221 ctggcaatcg actccatgca ggactgcctt aaggatatag atgtggacgt gattgcagga
     8281 acagagtcca gaggctttat ttttggtgta ccgatcgcat ataatcttca taaaccattt
     8341 gtaccgattc gtaaaaaagg caaacttccc cgcgaaacag tatctgtaag ctatgatttg
     8401 gaatatggca gtgcagagat tgaaatgcat aaagattcca taaaaccagg tcagaaagtg
     8461 gttatcgttg atgatctgat cgcaacaggc ggtacgatcg aagcagcgat caagctggtg
     8521 gaacagcttg gcggtgaggt tgtcaaggtt gtatttctca tggaacttgc aggtttaaag
     8581 ggacgcgaaa gactgaatgg gtatgatgta gcgtccgtaa tttgttatga tggtaaataa
     8641 gcacagctga ttgtgcagga caggcaggtg ggagcatatg acagagataa caaaaagtac
     8701 agaagcaaaa aaagatgaaa tgcaggttga aaaagagaag ctggaatctg taaagagagc
     8761 agatgcggca gtaaagacca tgcatgattt tacaagtccg gaggtgcttt ataaagaact
     8821 gataaacagt gttctgaagt atcatccatc aacagatatt tccatgatag agaaggcata
     8881 taaggttgca agtgaagctc atgaaggaca gaagagaaag tctggagagc catatatcat
     8941 tcatcctttg tgtgttgcca tcattctggc agatctggaa cttgacaaag aaacgatagt
     9001 tgcaggtctt cttcatgatg cagttgaaga tacctggatg acctatgagg aagtggagaa
     9061 ggaatttggt tcagaggttg cacttcttgt ggatggtgtt accaagctgg gacagttatc
     9121 ttattctgcg gataaagtag aagttcaggc agagaacctc agaaagatgt ttcttgccat
     9181 ggctaaggat atcagagtta ttctgatcaa gcttgcagac cgtcttcata atatgcgtac
     9241 cttacagtat atgcgtcctg aaaagcagca ggaaaaggcc agagagacca tggatattta
     9301 tgctcctatt gccatgcgtc tgggtatttc caagataaag gtagagctgg atgacctgtc
     9361 gctgaaatac cttaagccgg aggtatatta tgacctggtg cataaggttg ccctgcgtaa
     9421 aagcgagaga gaacagtttg taggtgcgat cgtaaaagaa gttaagaagc atatggatga
     9481 tgccaatatt aaggcacagg tggacggacg tgtaaaacac tttttcagca tctacaagaa
     9541 gatggtaaat caggataaga ctattgatca gatttatgat ttatttgctg tccgtattct
     9601 tgtagataca gtgaaggatt gttatgctgc ccttggtgta atccatgaga tgtataagcc
     9661 aattccggga cggtttaaag attatattgc catgccgaaa cccaatatgt atcagtcatt
     9721 gcataccaca ttgatcggac ccaacggaca gccctttgaa atccagatcc gtacttatga
     9781 aatgcacaga actgcagaat atggtatcgc tgcacactgg aaatataagg agtcgtctga
     9841 cggaaaagct cctgtaggta agagtgagga agagaaactg aactggctgc gtcagattct
     9901 ggaatggcag agagacatgt ctgataacaa agaattcatg agtcttctga agaatgacct
     9961 ggatcttttt gcggacagtg tttactgttt cactccacag ggagatgtta aaacacttcc
    10021 aagcggttct acaccggtgg attttgcgta cagtgttcac agtgcagtcg gaaataagat
    10081 ggtaggtgcc agagttaacg gtaagctggt tccgattgaa tatgagatca aaaacggcga
    10141 ccgtattgaa atcattactt cacagaattc tcagggacca agccgcgact ggctgaaact
    10201 ggttaagagt actcaggcaa agaacaagat taaccagtgg ttcaagaagg aattaaaaga
    10261 agataatatc cttaagggca aggagatgct tgcgcagtat gcgcgtgcaa agggatttaa
    10321 gatcgcaaat tatacaaaaa cccagtatct ggaggctgtt ttgcgtaaat atggtttcag
    10381 ggactgggat tcagtacttg ctgcaattgg tcatggcgga ttgaaagaag gtcaggtttt
    10441 caataagctg gtggaggcat atgataagga aaataagaag aatctgacag acgagcaggt
    10501 tcttgaggct gcttctgaga cacaggaaaa gcttcacatt gccaagagta agagcggcat
    10561 tgtggtaaaa ggaatccatg atgtggcagt ccgtttttcc aagtgctgta atccaatccc
    10621 gggtgatgag attgtaggtt ttgttacaag aggacgtgga atcacaattc atcgtacaga
    10681 ttgtgtcaat gtgctgaata tgtctgagac agacaggaca cgactgattg aggcagagtg
    10741 gcagcagcct gataccaagg aaaaagagaa gtatatggct gagattcagg tttatgcaaa
    10801 taaccgtaca gggcttcttg tggatctttc taaaatattt acagaacgta agatcgacct
    10861 gcgaagtatc aacagccgta caagcaagca ggagaaggca actatttcca tgagttttga
    10921 gattggaagc aaagaggaac tgcgttccct gctcgagaag atccgtcagg tagagagtgt
    10981 cattgacgta gagagaacta caggctgatc atggaaaaat ctgctggaac attattttat
    11041 ggaactgctg cagattgaca gaaaggaata acatgaagaa tttagaatta cagaaatgta
    11101 tattaggacc tgtatataca aattgctatc tccttaagaa taaagaaacc ggagaactga
    11161 tcattgttga tcccgcagat tgtccggaga agattgaaat gaagatttcc cggatgaatg
    11221 gaaaaccggt ggcgattctt cttacccatg gacattttga ccacattctg gctgcacagg
    11281 cagtaaagga gaaatataat attccgattt atgcctgtca tcaggaagag gagatgctcc
    11341 gcgaaccttc gatcaatatg actgtacatt atggacaggg atgttctatt gtgccggatg
    11401 tatttctgga ggatctggat gttatcagac tggcgggatt ttccgttcag atgatccata
    11461 caccgggaca taccaaagga agctgctgtt attatctgaa agatgaaggt gtattgttca
    11521 gcggtgatac agtgttctat ggctctgttg gaagaacgga ttttccgggt ggaagtacag
    11581 cagaaatcgt gagaagtctc cataaactgg tagattcgct tcctgaagag accgaggttt
    11641 tccccggaca tgatgcatct accactattg gttatgaaaa gaggtataat ccatttgtgt
    11701 aaaataggca ttctgtttga gaacagagat tttgaacatg atgtttatga actgatcaaa
    11761 gcgttttatc ccgaagcgga gatacatact ctttatgaaa atgctgaagc agagtatgac
    11821 ctccgcttca gtgtggaacg ggataatgac agttatatca taaaatacga aaggacagag
    11881 aatctgtcga aacaggaaac agagcaaaaa ggggtaattt ccgcagacat actttctaaa
    11941 gagaatgcag gctgtggaat acaggatgct catgctctga gaaaagagaa taaagataat
    12001 atcaaatatg ctctgtatca gttgttggta aaactgacgg gcagaactct tccatgggga
    12061 aatctgacag gaatacgtcc tgccaaactg gcaatgggaa tgatcgaatc cggaatgaaa
    12121 aatacggaag cagcccggga gatgcgtgag agatatctgg taagtccgca gaaaacagcg
    12181 cttgccatca ctattgcaaa cagggaaaga gagattctga aggatattga ctatgaaaat
    12241 ggatacagcc tttatattgg aatcccgttt tgcccaagta tctgtctgta ttgttccttc
    12301 agctcctatc cgctgaaagt gtgggagaag agaacagatg aatatgtgga agctctctgc
    12361 cgggaggtaa gagagactgc tcttatgatg aagggaagaa aactggacac catctatatt
    12421 ggcggcggta ccccgactac actgcttcca catcagatcc gtaagctcct ggatacagtg
    12481 ggagaagctt ttggctatga aggactggca gagtttactg tggaagccgg cagaccggac
    12541 agtattacac gtgaaaagct gatggcgatc agggagtatc cggtaacaag aatttccgta
    12601 aatccacaga ctatgaatca ggaaaccctg gatattatcg gccgcagaca tactgtggag
    12661 cagacaaaag aagcgtttca tctggcacga gagctgggat acgataacat taacatggat
    12721 ctgatcgtag gtcttccggg tgaggatatt cacatggtag agcggactct tgaacaggtt
    12781 cgtgaactgg caccggacag tattaccgta cattcactgg cagtgaaacg tgcagcaagg
    12841 ctgaatattt ttaaagagaa atatcaggaa atgtcttttg agaataatca ggagattatg
    12901 gatctgacca tgaaaaccgc atatgaaatg ggaatgggtc cttattatct gtacagacag
    12961 aagaatatga agggaaattt tgaaaatgtt ggctatgcaa aggttgacaa agcgggaatt
    13021 tacaatatac tgattatgga ggaaaaacag cctatcatcg cactgggggc aggcggttct
    13081 tccaagctgg tctttgacca tggacagaga attgaacgtg tggagaatgt aaaagacgtt
    13141 tctaattata tttcccgcat tgatgagatg atcgagagaa aacggacagc aatagctacc
    13201 tggctgtagg atgtggaggt aacattttgg acacagtaca aaagacagcg gcaggttcac
    13261 agcagaggat cctggaattt gaccttgctt ctgaactgca tcatggaatg ctggtaagta
    13321 atctggctta tgcggttgca gaggagatgg gactgccgca tgaacagtgc tatgagcttg
    13381 caatagcagg aatgctccat gatataggaa agctgaagct gacaagttat attaacggac
    13441 aggagcagga tcctctggtg atcgaggaac tgaagtatgt ccggatgcat tctacattgg
    13501 gatatgagga acttaaaggg cagggatatt cggattttgt attggagagt atcctgtacc
    13561 atcatgagaa ttatgatggc agtggatatc cgtccaataa agcaggtgat gacataccca
    13621 taggtgcccg gatactcaga gtctgcgatg tata
//
