LOCUS       c00227_gnlPro..        15108 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PFBDDIFG_227.
ACCESSION   c00227_gnlPro..
VERSION     c00227_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:56:13
            Original ID  :: gnl|Prokka|PFBDDIFG_227
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15108
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15108
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[96:5108]"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      97..5108
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /neighbourhood="10000"
                     /product="Rnf_complex"
                     /protocluster_number="1"
     cand_cluster    1..15108
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Complex1_51K and minimum(5, [FMN_bind,
                     FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N,
                     SLBB]))"
                     /kind="single"
                     /product="Rnf_complex"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15108
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Rnf_complex"
                     /region_number="1"
                     /rules="(Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4,
                     Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))"
                     /tool="gutsmash"
     CDS             3..77
                     /locus_tag="ctg227_1"
                     /transl_table=11
                     /translation="YKQVDKNVQKSIWILSKIEHFGGA"
     CDS             97..1413
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Complex1_51K"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: RnfC_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: SLBB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg227_2"
                     /sec_met_domain="SLBB (E-value: 1.3e-17, bitscore: 54.0,
                     seeds: 67, tool: rule-based-clusters)"
                     /sec_met_domain="Complex1_51K (E-value: 6.8e-49, bitscore:
                     156.2, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="RnfC_N (E-value: 6.8e-42, bitscore: 132.2,
                     seeds: 53, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.2e-05, bitscore: 14.1,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGILTFKGGVHPYDGKELSKNSPVVKYLPKGDMVYPLSQHIGAPA
                     AAIVQKGDHVLAGQKIADAAGFVSSPIHSSVSGTVKGIEPRLTATGSMVSSIIIENDQQ
                     YESVEFTPARLEDLSKEEILARIKEGGVVGMGGAGFPTQVKLAPKEPEKIDHILVNGAE
                     CEPYLTSDYRRMLDDSEKLIEGLRVMLKLFDNAKGYICIEDNKPDCIAKLKEMVKDIPR
                     IEVAELMTKYPQGGERFLIKAVTDREINSAMLPADAGCVVDNVDTVIAVYEAVILGKPV
                     MDRIVTVTGQGIKNPQNFDVLSGTDMAELIEAAGGLTDNVSKVISGGPMMGFAMYDTHV
                     PCIKTSSACLCLEKDDVADAEQTACINCGRCVGVCPGHVIPARLATFAEHGDMKSFQKF
                     DGMECCECGCCSYICPAKRPLTQMIKSMRKMVLASRKKK"
     CDS             1429..2406
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: NQR2_RnfD_RnfE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg227_3"
                     /sec_met_domain="NQR2_RnfD_RnfE (E-value: 7.7e-121,
                     bitscore: 393.4, seeds: 472, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQMLHVSSNPHVRDKMTTSKIMQLVALALLPTTLFGIYNFGLRA
                     LLVVVITVASSVFFEWIYDKLMHKKNTITDFSAVVTGLLLALNMPASIPLWMPVLGSAF
                     AIIVVKQLFGGLGQNFMNPALAGRCFLMISFAGKMTDFAVSDSFRGVVDTVSGATPLAA
                     LKQNGFTDSSVSVLHMFIGDIQGTIGETSALAILIGAAILLVFKVIDLKIPLTYIGSFA
                     VFVILYMLGTGKGFDVNYLFSHIFGGGLMLGAWFMATDYVTTPITPRGQYVYGVCLGVL
                     TAVFRLFGGSAEGVSYAIIFCNLLVPMIERVTRHPAFGKGGKKA"
     CDS             2403..3011
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FMN_bind"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg227_4"
                     /sec_met_domain="FMN_bind (E-value: 1.6e-20, bitscore:
                     64.1, seeds: 891, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNRIIKDTIAITVITLVAGLALGVVQDITADPIAKQEAQAKQDA
                     YKAVFADADSFETVDVDADAMQSYLDENGYAAQSIDETMLAKDASGNELGYAFTVTTSE
                     GYGGDIQFAMGIQDDGTLNGISILSIGETAGLGMRANTDAFKDQFKDKNVDKFEYTKTG
                     ATADDQIDALSGATITTNAMTNGVNAGLCAFQYEKGGNQ"
     CDS             3011..3721
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg227_5"
                     /sec_met_domain="Rnf-Nqr (E-value: 2.8e-72, bitscore:
                     232.9, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPNTPAERLYNGIIKENPTFVLMLGMCPTLAITTSATNGIGMGL
                     TTTVILAASNLMISLLRNFIPDRVRMPAFIVVVASFVTVVQLLLQGFIPSLYDSLGIYI
                     PLIVVNCIILGRAEAYASKNKPIASLFDGIGMGLGFTLSITCIGAVRELIGAGSLFGHQ
                     ILPLADAAAGKAGYEPITIFILAPGAFFVLAALSALQNKFKIGAAKRGIDPSNPDCGGS
                     CAACGNTMCKGKRG"
     CDS             3728..4303
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Rnf-Nqr"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg227_6"
                     /sec_met_domain="Rnf-Nqr (E-value: 6.2e-63, bitscore:
                     202.5, seeds: 650, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKELLIILVSSAIVNNVVLSQFLGLCPFLGVSKSVETAAGMGGAI
                     IFVITLSSFVTGIIYNAILVPTNLTYLQTIVFILLIAALVQFVEMFLKKTMPSLYQALG
                     VYLPLITTNCAVLGVALTNVQKEYNVLQGTVNGFATAVGFTISIVLMAGIREKIAYNDI
                     PKSFQGFPTVLLTAGLMAIAFFGFSGLI"
     CDS             4317..5108
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: Fer4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Rnf_complex: FeS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1020:4Fe-4S binding domain (Score: 31.8; E-value:
                     2.7e-10)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg227_7"
                     /sec_met_domain="Fer4_7 (E-value: 1.4e-10, bitscore: 32.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 6.9e-08, bitscore: 22.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="FeS (E-value: 2.2e-16, bitscore: 49.9,
                     seeds: 364, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.7e-05, bitscore: 15.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIGAIIAATVLVAAVGLFIGVFLGVAGKKFAVEVDEKEVAVREA
                     LPGNNCGGCGYPGCDGLAAAIAKGEAPVNGCPVGGEPVGKVIAAIMGQEVVETARQVAY
                     VKCAGTCEKTKDNYEYTGVEDCEMMAFIPGGGAKSCTYGCLGFGSCVKACPFGAIDVVN
                     GVAVVDKEACKACGKCVAKCPKHLIELVPYEQTTFVQCSSHAKGKAVTSACEVGCIGCK
                     KCEKTCPNGAITVDNFCAHIDYSKCTNCGACKEVCPRHIIQ"
     CDS             5243..5851
                     /locus_tag="ctg227_8"
                     /transl_table=11
                     /translation="MIAFVHGMAVDMTESSVVVEAGGIGYEIYMTGADLSEIRMGEDVK
                     VHTYFSVREDAMKLYGFRDKDDLQMFKLLLGVNGVGPKAALGVLAGITADELRFAILSD
                     DVKTLSKAPGIGKKTAQKLILELKDKMKLEDAFELKLAHEQERAAVGAGEVSDGRQEAV
                     EALVALGYSSADALRAVRKVTDVPPDDVEGLLKAALKNF"
     CDS             5931..6935
                     /locus_tag="ctg227_9"
                     /transl_table=11
                     /translation="MEKRIITTDVTEEDFSLEGNLRPQTLDDYIGQEKTKSTLKVYIEA
                     AKQRHDALDHVLFYGPPGLGKTTLSGIIANEMGVHMKVTSGPAIEKPGEMAAILNNLQE
                     GDILFVDEIHRLNRQVEEVLYPAMEDYAIDIMIGKGASARSIRLDLPKFTLVGATTRAG
                     LLSAPLRDRFGVMHHLEFYTHEELKTIIIRSAQVLGVEIDEKGAAEIAKRSRGTPRLAN
                     RLLKRVRDFAQVKYDGRITYDVACFALNLLEVDQYGLDKIDRRILQTMIVNFQGGPVGL
                     ETLAAAIGEDSGTLEDVYEPYLLQNGFLNRTPRGRMASALAYEHLGYQMPEKN"
     CDS             7070..7477
                     /locus_tag="ctg227_10"
                     /transl_table=11
                     /translation="MAVKNTAKVIIGGKIITLGGYESEEYFQKVASYINKKMDELSAMP
                     GYSRQPMETKHTLISLNITDDYFKAKKQAEVFEQDLQQKDQEMYDLKHELISLRMQIEE
                     AQKHEQEALEQKSLLEGKNKELEKQIDELLK"
     CDS             7606..9801
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg227_11"
                     /sec_met_domain="Peptidase_U32 (E-value: 2.3e-82, bitscore:
                     266.2, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRREEIELLAPAGSYEGFEAAIGAGADAVYVGGAAFGARAYAKNF
                     GEEELLRAIDTAHIHGRKLYLTVNTLLKNRELSEQLYDYLLPYYKEGLDAVIVQDMGVF
                     KMIREMFPGMHLHASTQMTVTGPEGMKFLEEQGASRVVTARELSLEEIRRMHETSPIEI
                     ESFIHGALCYSYSGQCLMSSILGGRSGNRGRCAQPCRLPYQTALCCGENGRRSEKRKAQ
                     ELCPLSLKDISTIEILPQILEAGVTSLKIEGRMKQPGYTAGVTSVYRKYLDLLFEKGAE
                     NYRVAEEDKRYLLDLFNRGGSCTGYYQMQNGPSMMAFSNEKKTGDVSPVLRKKKEKIQG
                     TFILFPGSPAILDVSCRGIHGFASVGEVQYAQNQPLTEERIRSQMEKLGNTEYEWENLE
                     IQMDENIFIPMKMLNEARREALESLENELLKPYKREENNGKKRLSEDAGRKADSPKQKN
                     LPIYISCEEKSTALALYKREGIHGMYLNADAMEVCLDDCVSRGMEMYLSLPHIMRGEMP
                     RELLTRIREWMDRGMTGFLVRNLETFAVLRKAGLAEKCVLDHSMYTWNDEAADFWKDQK
                     VLRNTVPLELNEGEIRHRDNRDSEMLIYGYLPLMISAQCVHKNLYGCNHKEEGVTLKDR
                     YDKEFTAKCICNPWKTENTDFCIPCYNIIYNSIPYGLLKEKSQIDRLGVSSLRLAFTIE
                     KPQDAVKIYEEFRDVYRDGKNPPKREYTKGHFKRGAE"
     CDS             10176..11180
                     /locus_tag="ctg227_12"
                     /transl_table=11
                     /translation="VIVAGVNVVALIVPVLIRKMKFLKDLTWVYAGIGIVLLAAVFVLA
                     KTSYGAKLSLMGIQPSEAIKITFVFFMAALLRKGADFSKVVQATVVAGLHVGILVISRD
                     LGSAVIFFAAYLVMIYVASRNVGYLALGLAGGSAGAVVAYHLFGHVRQRVTAWKDPMAV
                     YQNEGYQIVQSLFAIGTGGWFGMGLCQGSPEKIPVVKNDFIFSAICEELGGIFAICLIL
                     VCMSFFLMIVNIALKIKKPFYKLIALGLGTEYAFQVFLTIGGATKFIPMTGVTLPLVSY
                     GGSSVACTVLMLAIIQGLYILREDEDEEIERYRRKGTAQRVEEAPEAQSPGDF"
     CDS             11140..12591
                     /locus_tag="ctg227_13"
                     /transl_table=11
                     /translation="LKKRQKRKAREISEKRRPRNREYTLVSCFFVLIFVSMIGYLIYFN
                     YAKSDDFINSPYNTRQDTFSDRVVRGKIISADGQVLAQTNVYEDGTEERTYPYANMFAH
                     VVGYDTNGKSGLESEANFQLLTSHEFFLNQMKNEFKNQKNTGDSVITTLNADLQSTAYN
                     ALGDRRGAVVAIEPSTGKILVEMSRPDFDPNTISQNWDTLVNDSNDSSLLNRATNGAYP
                     PGSTFKVVTALDYFRTKGSLEGFSYLCEGSITREDHTIRCYGGTVHGQEDFYSAFANSC
                     NSAFAEIGTMLGGSSLKKTAENLLFNKSLPLSSYKKSTFTLNGKSSVAEVMQTAIGQGN
                     TLVSPMHMALITSAIANGGELMKPYLIDSVVSSDGETVKTTEPESYKRLMTTNEANILG
                     KLMKGVVENGTASALNGRGYTVAGKTGSAEFDENGSSHSWFIGYSNVDDPDLVVAIIVE
                     NGGTGSEAAVPIAEQIFDAYYYDKQ"
     CDS             12768..13223
                     /locus_tag="ctg227_14"
                     /transl_table=11
                     /translation="MIEATSCGGVVIHRGKILTLYKSYRNRYEGWVLPKGTVEPGETHE
                     QTALREVMEEAGVRATIVKYIGKSQYNFTVPEDVVFKEVHWYLMTADNYHSKPQREEFF
                     VDSGYYKFHEIYHLLRFSNEKQIVERAYQEYLEMRSNGLWGKQHKYY"
     CDS             13328..13639
                     /locus_tag="ctg227_15"
                     /transl_table=11
                     /translation="MLKWQENFLAGESVKDPEKIKKKLNSGKPVLGIYLLTLSENPVNL
                     MDIIPAAMLIQKSFYGICPKIIGMAKGKEEALEMVRSLIDEMYRETGTFATAEYIENR"
     CDS             13644..14672
                     /locus_tag="ctg227_16"
                     /transl_table=11
                     /translation="MLHILWLILKFILIILGILLGLLLLAVLLVLFCPVRYKASAVKAE
                     GGWKQTEGEGIVSWLFHGISLRAEWKDQQMEISFHLFGIPVDKLLKKRQEKRAITKKSG
                     KNPEKSGAEKVSVSGIDGNREEEHKKSVVDHPKSENMETEDLKTDRNSASGTSADTERI
                     RNSQISGQQELNADDTDRNSLKKRQFFIKGIYDRIRNIFQSIRTKLQNIRRTFGKIKKN
                     VSWWKAFIEHPRVTAARKLVWKHGKFLLKHIFPTRIEGQVTFSFEDPALTGAALAVLGM
                     TIPFHKNCIQIDPRFDSENYLYGNIRAKGRIYGFVPVRAAVSIYFNKNIKYVIKRWKTR
                     RA"
     CDS             14675..15046
                     /locus_tag="ctg227_17"
                     /transl_table=11
                     /translation="MANENNFKETVNSLFKGMDSFISAKTVVGEAIHVGDTIILPLMDV
                     SFGVGAGAFSGEKKDNGGGGMAGKMTPCAVLVIQNGTTKLVNVKNQDGLTKILDMVPDF
                     VDRFTSGKGDEESVGESEK"
ORIGIN
        1 attataaaca ggttgataaa aatgtacaaa aaagtatatg gattttatca aaaatagagc
       61 actttggtgg tgcttaatat aaaaggaggg aacgaaatgg gaattttaac ctttaagggt
      121 ggtgttcatc cttatgacgg aaaagaatta tccaagaaca gtccggtagt gaaatatctg
      181 ccaaagggag atatggtata tcctctttcc cagcatatcg gtgctccggc tgcagcgata
      241 gttcagaagg gagaccatgt gctcgcagga cagaagatcg cagatgctgc ggggtttgtc
      301 tcatcaccga tccattcgtc tgtttccggt acggtaaaag gaatcgaacc gcgcctgaca
      361 gcaacaggtt ctatggtcag ttccattatc attgagaatg accagcagta tgaaagtgtg
      421 gaatttactc ctgcacgtct ggaagatctt tcgaaagagg agattttggc gagaattaaa
      481 gaaggcggag ttgtgggaat gggcggcgcc ggattcccca cacaggtaaa gcttgcgcca
      541 aaggaaccgg agaagatcga tcatatcctt gtaaacggtg ccgagtgtga accctatctt
      601 accagtgact acagaagaat gctggatgac tctgagaagc tgatcgaggg cttaagagtt
      661 atgctgaagc tctttgacaa tgcgaaggga tatatctgta ttgaggataa caagcctgac
      721 tgtattgcga aactgaaaga aatggtaaaa gatattccac gtattgaagt agcagagctg
      781 atgaccaagt acccacaggg tggtgagcgt ttcctgatca aggctgtcac agacagagag
      841 attaactctg ccatgcttcc ggcagatgca ggatgcgtag ttgacaacgt agataccgta
      901 attgctgttt atgaagccgt tatccttgga aaacctgtta tggaccgtat cgtgacagta
      961 acaggacagg ggattaagaa tccgcagaac tttgatgtcc tttccggaac agatatggca
     1021 gagcttatag aagctgccgg cggactgaca gacaatgtat ccaaagtaat ttcaggtggt
     1081 cctatgatgg gatttgccat gtatgacact catgtaccat gtattaagac aagctccgca
     1141 tgtctctgcc tggagaagga tgatgtggca gatgccgaac agactgcatg cattaactgc
     1201 ggcagatgtg taggagtctg tcccggccat gtcattcctg caagacttgc aacctttgca
     1261 gagcatggtg acatgaagag cttccagaaa tttgatggta tggagtgctg cgaatgtggc
     1321 tgctgcagtt atatctgccc tgccaagcgt ccgctgaccc agatgatcaa atctatgcgt
     1381 aagatggttc tggcaagccg taagaaaaag taaaaggggg acatcgtaat ggatcagatg
     1441 ttacatgtat catccaatcc ccatgtccgg gataagatga caacaagcaa aatcatgcag
     1501 cttgtggcac tggcgcttct gccgaccaca ctgtttggaa tttataattt tggccttcgt
     1561 gccttactgg tagtagtgat caccgtcgct tccagtgtat tctttgagtg gatttatgac
     1621 aagctgatgc ataagaagaa cacaattaca gacttcagtg cagttgttac aggtttatta
     1681 cttgcattaa atatgcctgc atcaattccg ctctggatgc ctgtacttgg cagtgcattt
     1741 gcgatcatcg ttgtaaaaca gctctttggt ggtctgggac agaacttcat gaacccggca
     1801 cttgcaggaa gatgtttcct gatgatctct ttcgcaggaa agatgacaga cttcgcagta
     1861 agcgacagct tcagaggtgt ggtagatact gtatccggtg caactcctct ggcagctctg
     1921 aaacagaatg gatttacaga cagttctgta tctgtattac atatgtttat cggtgatatc
     1981 cagggaacta tcggtgagac ttctgccctt gcgatcctga tcggagcagc aatccttctg
     2041 gttttcaagg tgatcgatct gaagattccg cttacctata ttggaagttt cgcagtattt
     2101 gtaatccttt acatgcttgg aacaggcaag ggatttgacg tgaactatct gttcagccac
     2161 atcttcggcg gtggtcttat gcttggtgca tggtttatgg ctacagacta tgtcacaaca
     2221 ccgatcacac caagaggaca gtatgtatac ggtgtctgcc ttggtgtact gactgcggtc
     2281 ttccgtctct ttggcggttc cgcagagggc gtatcttatg cgatcatttt ctgcaacctg
     2341 ttagttccga tgattgaacg tgtgactcgt cacccggcat ttgggaaagg gggcaaaaag
     2401 gcatgagtaa cagaattatc aaagatacca tagccattac agtgatcaca ctggtggcag
     2461 gacttgccct tggtgtagtc caggatatta cagcagatcc tattgcaaag caggaagcac
     2521 aggcgaaaca ggatgcgtat aaggcagtat ttgcagatgc ggacagcttt gagacagtgg
     2581 atgtggatgc ggatgccatg cagtcttatc tggatgagaa cggatatgcg gcacagtcca
     2641 tagatgagac tatgcttgcc aaagatgctt caggcaatga actgggatat gcatttacag
     2701 taaccacttc cgagggttac ggcggagata tccagtttgc aatgggtatc caggatgacg
     2761 gtaccttaaa tggaatttcc attctttcca tcggtgagac cgcaggtctt ggtatgagag
     2821 caaacacaga tgcatttaag gatcagttca aagataagaa cgtagacaaa tttgaatata
     2881 caaagaccgg tgccacagcg gatgatcaga tcgatgcgtt aagtggtgcc actattacaa
     2941 cgaatgccat gacaaacggt gtcaatgccg gattatgtgc attccagtat gagaaagggg
     3001 gaaatcagtg atgaaaccaa acacacctgc tgaacgttta tataacggaa tcatcaaaga
     3061 aaatcctacc tttgtactga tgcttggtat gtgtcctaca ctggctatca ccacatctgc
     3121 aaccaatggt atcggaatgg gacttactac aacagtgatc cttgcagcat ccaacttaat
     3181 gatctctctt ctgagaaact ttattccgga cagagtgcgt atgcctgcat ttatcgtagt
     3241 tgttgcttcc tttgtaacag ttgtacagct tcttttacag ggatttattc caagcctgta
     3301 tgactccctt ggaatctata ttcctctgat cgtagttaac tgtatcatcc ttggacgtgc
     3361 agaagcatat gcatccaaga ataaaccgat tgcctctctg tttgatggta ttggtatggg
     3421 tcttggattt accttaagta tcacctgtat cggtgcagta cgtgagctga tcggcgcagg
     3481 ttctctgttc ggacatcaga tccttcctct ggcagatgct gcagcaggta aggctggtta
     3541 tgaaccgatc acaatcttta tcctggcacc cggagcattc tttgttctgg cagcgctttc
     3601 tgcattacag aacaaattca aaatcggtgc agccaaacgt ggcattgatc caagtaatcc
     3661 tgattgcggc ggaagctgtg cagcctgtgg caataccatg tgtaagggaa aaagggggta
     3721 atggattatg aaagaacttt tgatcatact tgtaagctca gcgattgtaa ataacgtagt
     3781 cctcagccag ttccttggtc tctgtccttt ccttggtgtt tccaagagtg ttgagacagc
     3841 agccggcatg ggcggtgcga tcatcttcgt tattacactg tcatcttttg tgacaggtat
     3901 tatttataat gctatcctgg ttcctacgaa cctgacttat ctgcagacta tcgtattcat
     3961 cctgctgatc gcggcgctgg tacagtttgt agagatgttc cttaagaaga caatgccttc
     4021 cctgtatcag gcacttggtg tgtatcttcc actgatcaca acaaactgtg cagttcttgg
     4081 tgttgccctt acaaatgtgc agaaagagta taatgttctt cagggaacag tgaacggatt
     4141 tgcaacagca gtgggcttta ctatttccat cgtgctgatg gctggtatcc gtgagaaaat
     4201 cgcatacaat gacattccaa aatccttcca gggattccct acagttctgc tgacagccgg
     4261 actgatggca attgccttct tcggattttc aggactgatt taaggagggg actggtatga
     4321 atataggagc aattatcgcg gcaactgtac tggttgcggc agtaggtctt tttatcggtg
     4381 ttttccttgg tgttgccggt aagaagtttg ctgtggaagt ggatgagaag gaagttgctg
     4441 ttcgtgaggc gcttcccggt aataactgcg gtggctgtgg ttatcccggc tgtgatggtc
     4501 tggcagcagc gatcgccaaa ggtgaggcac ctgtaaatgg atgtccggta ggcggtgagc
     4561 ctgtcgggaa agtgatcgca gcgatcatgg gacaggaagt tgtggagact gcccgtcagg
     4621 tggcgtatgt gaagtgtgcg ggtacctgtg agaagacgaa ggataattat gagtatacag
     4681 gtgtggaaga ctgtgagatg atggctttca ttcccggtgg tggtgcgaag tcctgtactt
     4741 atggatgcct tggttttgga agctgcgtga aggcctgtcc gtttggggcg attgatgttg
     4801 tgaacggtgt ggcggttgtt gataaggagg cttgtaaggc ctgcggtaag tgtgttgcca
     4861 agtgtccgaa gcatctgatc gagcttgtgc cctatgagca gactacgttt gtgcagtgta
     4921 gttctcatgc gaaaggtaag gctgttactt ctgcgtgtga ggttggctgt atcggatgta
     4981 agaagtgtga gaagacttgc ccgaatgggg cgattacggt tgataatttc tgtgcgcata
     5041 ttgattatag taagtgtacg aattgtgggg cttgtaaaga ggtttgtccg agacatatta
     5101 ttcagtaatg ggaggaagaa ctgctgtgtg aaggcatggc ggttcttttt ttcgattaag
     5161 ggatgcgaat atatgtttgc gttatggggt gggatgtggt atgatgaatc ggaagtgatg
     5221 aatttgggac ggaggatgta tcatgattgc gtttgttcat ggaatggctg tggatatgac
     5281 tgagagctcg gtggttgttg aggccggggg gattggttat gagatatata tgacgggggc
     5341 agatttgtct gagattcgta tgggggagga tgtgaaggtc catacttatt ttagtgtgag
     5401 agaggatgcc atgaagctgt atgggttcag ggataaggat gatctgcaga tgtttaagct
     5461 gcttcttggc gtgaatggtg tggggccgaa ggctgcgctg ggagttctgg cggggattac
     5521 agcggatgaa ttgaggtttg caattctttc ggatgatgtg aagacgttgt cgaaggctcc
     5581 gggtatcggg aagaagacgg ctcagaagct gattcttgag ctgaaggata agatgaagct
     5641 ggaggatgcg tttgaattga agctggctca tgagcaggag agggcagcag tgggagccgg
     5701 tgaggtttcg gatggcaggc aggaggctgt tgaggctctg gttgcgctgg gatacagcag
     5761 tgcggatgcg cttcgggcgg tgcgtaaggt tacggatgtg ccgccggatg atgtggaagg
     5821 tcttttgaag gctgcgctga agaattttta actgaagcag gatttcacgc tctggtagat
     5881 tggattgcct gtattgttat agaattgtta taggttagga tgggtaacag atggagaaac
     5941 gtattataac tacggatgtg acggaggagg atttttctct ggaggggaat ctccggccgc
     6001 agacgttgga tgattatatt ggtcaggaga agaccaagag tactttgaag gtttatatag
     6061 aggctgcgaa gcagaggcat gatgcattgg atcatgtttt gttttatggt cctccggggc
     6121 ttggcaagac tactctttcg gggattattg ccaatgagat gggggttcat atgaaggtga
     6181 cttccgggcc ggctattgag aagccggggg agatggctgc gatccttaat aatctgcagg
     6241 agggagatat tctgtttgtg gatgagatcc accgcttgaa caggcaggtg gaggaggtcc
     6301 tttatcctgc tatggaggat tatgctattg atattatgat cgggaaggga gcttctgcca
     6361 ggtctatacg tctggatctg ccgaagttta cactggtggg ggcgactacc agggcaggac
     6421 ttctgtctgc acctcttcgt gaccgttttg gtgtgatgca tcatctggag ttttatactc
     6481 atgaggagct taagacgatc attatccgtt ctgctcaggt tcttggagtg gagattgatg
     6541 agaagggtgc ggctgagatt gccaagagat ccaggggaac tccgaggctt gccaaccgtc
     6601 tgctgaagag ggttcgtgat tttgcgcagg tgaagtatga tggacggatt acttatgatg
     6661 tggcgtgttt tgcgctgaat cttctggaag tggatcagta tggtctggat aagattgaca
     6721 gaaggattct tcagactatg atcgtgaatt ttcagggtgg tcctgtggga ctggagactt
     6781 tggctgcggc gataggggag gattccggta cgctggagga tgtgtatgag ccttatctgc
     6841 tgcagaatgg attcctgaac cgtacgccga gaggacgtat ggcatcggcg cttgcgtatg
     6901 agcatctggg ctatcagatg ccggagaaaa actgaagtta agggcgtaaa aatataaaaa
     6961 agtaaaagtt ttttaaaaat tcctatacat ttcgactgct ttcgagtata atgaagtaaa
     7021 tgtccggggt tccgggcaga ttgaaggaag atacaggagg ctcgtacgga tggcggtcaa
     7081 aaatacagca aaggtaatca taggtggtaa gattattacg ctgggaggct atgaatcgga
     7141 agaatatttt cagaaagtag catcctatat aaataaaaag atggatgagt taagtgctat
     7201 gccgggttac agcagacagc ccatggagac caagcataca cttatcagcc tgaatattac
     7261 agatgactat tttaaggcaa agaaacaggc ggaggttttt gaacaggatt tacagcagaa
     7321 ggatcaggag atgtatgatc tgaagcatga gctgatctcg cttcgtatgc agattgagga
     7381 agcgcagaag catgaacagg aagccctgga acagaagagc cttctggagg gaaagaataa
     7441 ggaactggaa aagcagattg atgagctgct gaaataacag aggggggatt acttcggtga
     7501 tttccccttt atgatttgtt tcatatgtat tcgatttgaa tattatagca atgctcataa
     7561 ataatgcatt taagatgact gttatagaaa acgtgaggta tagaattgag aagagaagag
     7621 attgaacttc tggcacctgc cggttcctat gagggatttg aggcagcgat cggtgcaggt
     7681 gcagatgcgg tttatgtagg gggagcagcc tttggcgcgc gggcctatgc gaagaatttc
     7741 ggagaggaag agcttttgcg tgccattgat actgctcata tccatggcag gaaactttat
     7801 ctgacagtga atacgctgtt gaagaacagg gaactgtctg aacagttgta tgattatctg
     7861 cttccatatt ataaggaagg tctggatgcg gtgatcgttc aggatatggg tgtgtttaag
     7921 atgatcaggg agatgtttcc gggtatgcat cttcatgcca gcacgcagat gactgtgaca
     7981 ggtccggagg ggatgaagtt tctggaagaa cagggtgctt ccagagtggt aactgccaga
     8041 gagctttccc ttgaggaaat ccggaggatg catgagacaa gtcctatcga gattgaatct
     8101 tttatccatg gagctttatg ttacagttat tcgggacagt gcctgatgag cagtatcctg
     8161 ggtggaagaa gcggtaacag aggaaggtgt gcacagcctt gccgtctgcc ttaccagacg
     8221 gcgctttgtt gcggggaaaa tggcagacgg tcagagaaaa ggaaagcgca agaactatgt
     8281 cctctgagtc tgaaggatat ttctacgata gagattcttc cgcagattct ggaggctggt
     8341 gttacttctc ttaagataga gggcaggatg aagcagccgg gatatacagc aggggtaact
     8401 tctgtatatc ggaagtacct ggatcttctt tttgagaagg gagctgagaa ttacagggta
     8461 gcagaggagg ataagagata tctgctggat ctgtttaaca ggggaggttc ctgtaccggt
     8521 tattatcaga tgcagaatgg tccgtccatg atggcattca gcaatgagaa gaaaacagga
     8581 gatgtcagtc ctgtattaag aaaaaagaaa gaaaaaattc agggaacatt cattcttttt
     8641 ccgggaagtc ctgctatact ggatgtgtca tgcaggggaa tccatggatt tgcgtctgtg
     8701 ggtgaggtac agtatgcgca gaaccagccg ctgacagagg agcgcatccg ttcacagatg
     8761 gagaagcttg gaaatacaga atatgagtgg gaaaatctgg aaatccagat ggatgagaat
     8821 atttttatcc cgatgaaaat gctgaatgag gcgagaagag aggcactgga atctctggaa
     8881 aatgaattgc tcaaaccata taagagagaa gaaaataatg ggaagaaacg cttatcagag
     8941 gatgccggaa gaaaagcaga ttcgccaaag cagaaaaatc ttccgattta tatttcctgt
     9001 gaagaaaaat ccactgcact ggcgttatat aaaagagagg ggatacatgg aatgtatctg
     9061 aacgctgatg ccatggaggt ctgcctggat gactgtgtaa gcagaggaat ggagatgtat
     9121 ctgtctcttc cgcatattat gagaggtgag atgccccggg agcttctcac caggatcaga
     9181 gagtggatgg acagaggaat gacaggattt ctggtaagaa atctggagac ttttgcagtt
     9241 ctgcgaaagg caggtctggc tgagaaatgt gttctggatc acagtatgta tacatggaat
     9301 gatgaagctg ctgatttctg gaaagatcag aaagtcctca gaaatacggt accgcttgag
     9361 ctgaacgaag gggaaatccg acacagagat aaccgggaca gcgagatgct gatctacgga
     9421 tatctgcctc ttatgatatc ggcccagtgt gtgcataaaa atctttacgg atgtaatcat
     9481 aaggaagaag gggtaacttt aaaagaccgt tacgataaag aatttacggc gaaatgtata
     9541 tgtaacccat ggaaaactga gaatacagat ttctgtatac cctgctataa tatcatttac
     9601 aacagtatcc cttacggcct gttgaaagag aaatcacaga tagacagact tggtgtctct
     9661 tccctgagac ttgcatttac cattgagaag cctcaggatg cggtgaagat atatgaagag
     9721 ttcagagatg tttatcgtga tgggaagaat cctccgaaac gggaatatac aaagggacat
     9781 tttaaaagag gagccgagta aggcatatga ttaatgtaat tgtagaatta tccaagtatg
     9841 tgatccttac cctgatggtg atttatacct ttcactgttt ctatctggtg aaacagcaga
     9901 gtgaggagga gagaaacgaa tcgctgcgcc agcagctgat gcttatcttt tttatggatt
     9961 tcactgcgtt tctggtcatc tacctgaaga caggtaagtt gcaggtcgtg ttgttttatg
    10021 tcgaaatgat ggcatttttt gcgggaatcc agattttgta caggattttt tataagaaag
    10081 catcgatttt actgctcaac aatatgtgca tgcttctcag cgtaggattt attatgctgt
    10141 gcaggctgga tgtttccaca gctaccagac agctggtgat cgtggcaggc gtaaatgtgg
    10201 tggcattgat cgtacctgtc ctgatcagga agatgaaatt tctcaaggac ctgacatggg
    10261 tttatgcggg aatcggaatc gttttgctgg cggcggtatt tgtgcttgca aagacaagct
    10321 atggagcaaa actttccctg atgggaatcc agccttcaga ggcgataaag attacatttg
    10381 tgttctttat ggcggcattg ctgagaaaag gtgctgattt ttcaaaagtg gtccaggcta
    10441 cggtagtggc gggactgcat gtggggattc ttgtaatttc cagagacctt ggaagtgcag
    10501 tgatcttctt tgcggcatat cttgtgatga tttatgtggc atccagaaat gtgggatatc
    10561 tggcacttgg tcttgcaggc ggatctgcag gggcagttgt cgcatatcat ctgtttggcc
    10621 atgtgcgtca gagagtgaca gcctggaagg atcccatggc ggtatatcag aatgaaggat
    10681 accagatcgt tcagtcactg tttgccattg gaaccggcgg atggtttgga atgggattgt
    10741 gtcagggttc gcctgagaag attcctgttg tcaagaatga ctttatattc agtgcaatct
    10801 gtgaggaact gggtgggatt tttgcaatct gcctgatcct ggtatgtatg agtttctttt
    10861 tgatgatcgt aaatattgcg cttaagatta agaaaccatt ctacaaactg atcgcacttg
    10921 gacttggtac ggaatatgca tttcaggtat ttctgacaat tggcggagca acgaaattta
    10981 tccctatgac aggtgtaact cttcctctgg tcagctatgg aggaagttct gtcgcgtgta
    11041 cagtactgat gctggcgatc attcagggat tgtatatttt gagagaagat gaggacgaag
    11101 aaattgagag atatcgaaga aaaggaacgg cgcagagagt tgaagaagcg ccagaagcgc
    11161 aaagcccggg agatttctga aaagagaagg ccccgtaaca gagagtatac actggtatcc
    11221 tgcttttttg tgctgatctt tgtcagtatg atcggatatc tgatctactt taattatgca
    11281 aagagcgatg attttatcaa tagtccctat aatacaaggc aggatacttt ttcagacagg
    11341 gttgtaagag gtaagatcat atctgcagat gggcaggtgc ttgcccagac caatgtttac
    11401 gaagacggaa cagaggaacg tacttatccc tatgcaaata tgttcgctca tgtagtcgga
    11461 tatgacacta atggaaaaag cggactggaa tcagaggcga acttccagct tctgacttct
    11521 catgaatttt tcctgaacca gatgaaaaat gagtttaaga atcagaaaaa tacgggtgat
    11581 tctgtgatca cgacgttaaa cgcagatctt cagtcaactg cctataatgc acttggtgac
    11641 aggagagggg cggttgttgc catagaaccc tctacaggta agattctggt ggaaatgagc
    11701 agaccggact ttgacccgaa tactatttcc cagaactggg acacactggt aaatgattcc
    11761 aatgacagca gtctgttgaa cagagctaca aacggagcct atcctccggg atctacattt
    11821 aaggtggtaa ctgccctgga ctatttcaga accaagggca gtctggaggg attttcctat
    11881 ctctgtgagg gaagtattac cagagaagat cacacgatca ggtgctatgg cggaactgtt
    11941 catggacagg aagattttta cagtgctttt gccaattcct gtaacagtgc atttgcagag
    12001 atcggaacca tgctcggagg cagttctctg aaaaaaacag ccgagaatct tctttttaat
    12061 aagagtcttc cgctttcttc ctataaaaag agtactttta cattaaatgg aaaatcttct
    12121 gttgcagagg ttatgcagac tgccatcgga cagggtaata cgttggtatc acctatgcat
    12181 atggcgctga ttaccagtgc gatcgccaat ggcggggagc tcatgaagcc ttatctcatt
    12241 gattctgttg taagttcaga cggagagaca gtgaagacaa cagagccgga gagctataaa
    12301 cgtctgatga caacaaatga ggcgaatatc cttggaaagc ttatgaaagg tgttgtggaa
    12361 aacggaaccg catcggctct gaacggaaga ggatatacag tggcaggcaa gaccggatca
    12421 gcggaatttg atgagaatgg ttccagtcat tcctggttta tcggttattc caacgtggat
    12481 gatccggatc tggtagttgc gatcattgtt gagaatggcg gtaccggaag tgaagcagca
    12541 gtgcccatcg cagagcagat atttgatgcg tattattatg ataagcaata ataaattcca
    12601 tgttgcaggc aatctggaat gaattttggc tacgtgactg cgaagggagt gaccagtaat
    12661 taataggtaa tatgttatga aatgataatt atagcttgcg ggtttggaaa aaaagagata
    12721 tactatactc agtttataat accacgcaaa acaggaggga ttgcattatg atagaagcaa
    12781 cgagctgtgg cggtgtggta attcatcggg gtaagattct tactttgtat aaatcttaca
    12841 ggaaccgtta tgagggctgg gtattgccga aaggaacagt ggaaccaggc gaaacgcatg
    12901 aacagacagc attgcgggaa gtgatggaag aggctggagt gcgtgcgacc attgtgaaat
    12961 acatcggaaa gagccaatat aactttaccg ttccggagga cgtggttttc aaagaggtac
    13021 actggtatct tatgactgcg gataattatc atagtaagcc ccagagagag gagttttttg
    13081 tagattccgg atattataaa tttcatgaga tctatcatct gctgaggttt tcaaacgaga
    13141 agcagatcgt agagcgtgct tatcaggaat atttggagat gagaagcaat ggactctggg
    13201 gaaaacagca taagtattat taacgagaga acagggctgt gtttttttgc aacgcagccc
    13261 ggtttaaatt ttggagaaaa tggaaatact gtaactgaag tgttatagaa acgggagagg
    13321 gtgtaagatg ctgaaatggc aggagaattt tcttgcaggg gaatctgtaa aggatcctga
    13381 gaagataaaa aagaaactga acagcggaaa accggttctg ggcatttatc tccttactct
    13441 gtcagagaat cctgtgaatc tgatggatat tattcctgca gcaatgctga tacagaagag
    13501 tttttatgga atctgtccga agatcatagg aatggcgaag ggcaaagagg aagccttgga
    13561 gatggtgcga agtctgatcg atgaaatgta cagggaaacg ggaaccttcg caacagctga
    13621 atatatagaa aacaggtgag aatatgttac atattttatg gctgatcctt aaatttatac
    13681 tgatcatcct gggaattctg ctgggccttc ttttactggc agttcttctt gtactgttct
    13741 gtcctgtaag atataaggca tcagctgtca aggcagaagg tggctggaaa cagacagagg
    13801 gagagggtat cgtaagctgg ctgtttcatg ggatttcgct gagagcggaa tggaaagatc
    13861 agcagatgga gatatccttt catctgtttg gaattcccgt agacaagttg ttgaaaaaac
    13921 ggcaggagaa gagggctata acaaagaaat ccgggaaaaa tccggagaaa tccggcgcag
    13981 aaaaggtatc tgtatccggc atagacggaa acagggaaga agagcataaa aaatcagtgg
    14041 ttgatcaccc gaaatcagag aatatggaga ctgaggatct gaaaacagac agaaattcag
    14101 cttcaggtac atctgctgat acagagagga tcagaaacag tcagatatcc ggacagcagg
    14161 aactgaatgc agatgataca gatcggaata gtctaaagaa gaggcagttt tttataaaag
    14221 ggatctatga ccggatccga aatatttttc agtcgattcg tacaaaactg caaaatatcc
    14281 gcaggacatt cgggaagatt aagaagaatg tgtcctggtg gaaggcgttt atagaacatc
    14341 ccagagtgac agctgccaga aaacttgtat ggaaacatgg aaaatttttg cttaagcata
    14401 tttttcctac aaggatagaa gggcaggtta ctttttcttt tgaagatccg gcgctgacag
    14461 gtgcggcact tgctgtactt gggatgacaa ttccatttca caaaaactgt atacagatcg
    14521 atccccgctt tgacagtgag aattatctgt atggaaacat cagggcaaaa ggcaggattt
    14581 acggatttgt tcctgtgcgg gcagcagtga gtatttattt caataaaaat ataaaatacg
    14641 ttataaaacg ttggaaaacc aggagggcat gaccatggca aatgaaaaca attttaaaga
    14701 aaccgtaaat tcattattca agggaatgga cagttttatt tctgcgaaaa cagtggtagg
    14761 agaggcaatc catgtaggcg atacgatcat tcttcctctg atggatgtat ctttcggtgt
    14821 aggtgccggt gctttttccg gagagaagaa ggataacggc ggcggcggaa tggcaggaaa
    14881 gatgactccc tgtgcagtgc ttgtgatcca gaatggaaca acaaagctgg tcaatgtgaa
    14941 aaatcaggat ggtctcacca agatccttga tatggttccg gattttgtag accgttttac
    15001 ctccggaaaa ggtgacgaag aatctgtcgg cgaatcagaa aaataatttt tgcatagact
    15061 atagcaaacc gatgaaaaag gtgcagaaga attggaaaag ctgttcgg
//
