LOCUS       c00235_gnlPro..        13455 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PFBDDIFG_235.
ACCESSION   c00235_gnlPro..
VERSION     c00235_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:56:13
            Original ID  :: gnl|Prokka|PFBDDIFG_235
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13455
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13455
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[206:3455]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      207..3455
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13455
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13455
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(207..1295)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg235_1"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1.2e-14,
                     bitscore: 45.0, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIDEKKMRENLEILKKVQEDTGCKILLAQKAFSGFALYPMIGKYL
                     AGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNSTAQLKKFKEVC
                     TGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDGLHFHTLCEQNA
                     DDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQHMKETYDLDIYL
                     EPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRPPLKDSGEAGEK
                     AYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTFNGMPLPDIAVM
                     HEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(1318..2508)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg235_2"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 6.6e-44, bitscore:
                     141.4, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 7e-26, bitscore:
                     81.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASRTKEKCDALKEKIESTTKTKIETAKVDADNAAEVAELIRAY
                     KPDAVLNVALPYQDLTIMDACLEAGADYIDTANYEAEDTEDPTWRAIYEKRCKEKGFTA
                     YFDYSWQWAYDEKFKEAGLTALLGTGFDPGVTSVFSAYALKHYFDEIHTIDILDCNGGD
                     HGYPFATNFNPEINLREVSANGSYWEDGHWVETEPMEFKSVYDFPEVGKKDMYLLHHEE
                     IESLAKNIPGVQRIRFFMTFGQSYLTHMKCLENVGMLSTAPVEFNGQEIVPIQFLKALL
                     PDPASLGPRTVGKTNIGCIFTGVKDGKEKSIYIYNVCDHQECYKEVESQAISYTTGVPA
                     MIGSMMVVTGQWKKPGVFNVEEFDPDPYMEALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(2595..3455)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg235_3"
                     /sec_met_domain="Spermine_synth (E-value: 6.5e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 9.7e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(3458..4969)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_4"
                     /sec_met_domain="OKR_DC_1_C (E-value: 9.6e-14, bitscore:
                     42.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.3e-126,
                     bitscore: 412.8, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIELYLPVHDDRKRGTCQMDYERQQHAPIYEALERFRKKRVVPFD
                     VPGHKRGRGNPELAQLLGEKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAF
                     LMVGGTTSAVQSMILSVCKAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGIS
                     LGMEVSQVEKAMDENPDAVAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHL
                     YFGRNLPVSGMAAGADMAAVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSAS
                     YLLLSSLDISRRNLALRGEESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFD
                     VTKLSIYTLGNGLAGIEVYDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALA
                     DIERLYKKDSTGMLSGEYIAPAVVASPQQAFYAEKESLPMEQTAGRISGEFVMCYPPGI
                     PILAPGEMVTQEIVEYILYARDKGCSMQGMEDPKVENLQVLKGGI"
     CDS             5978..7663
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_5"
                     /sec_met_domain="FTHFS (E-value: 9.2e-276, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(7772..9196)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_6"
                     /sec_met_domain="Lyase_1 (E-value: 4.9e-95, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 1.8e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             9312..10247
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg235_7"
                     /sec_met_domain="LysR_substrate (E-value: 9.1e-34,
                     bitscore: 107.1, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 7.7e-19, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFEHYIYQKEQ
                     LLLAVPKNYSVNTRLQEYQIPIEEIRNEQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(10359..11816)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg235_8"
                     /sec_met_domain="FGGY_C (E-value: 1.4e-38, bitscore: 123.0,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 9e-81, bitscore: 261.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFAQSMEGMKELTKDIDRAQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARNLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
     CDS             complement(11961..13442)
                     /locus_tag="ctg235_9"
                     /transl_table=11
                     /translation="MNNIPVVKLGLIAVSRDCFPIQLSEKRRAAIKETYKGELYECPVT
                     VENEKDMEKALEDVNKAECNALVVFLGNFGPETPETLIAERFDGPCMYVAAAEGDGDMI
                     NGRGDAYCGMLNCSYNLKMRHLKAYIPEYPVGTADDIAKMIADFVPVARAVIGVSNLKI
                     ITFGPRPQDFFACNAPIKGLYELGVEIEENSELDLLVSFKEHENDPRIPEVCADMAKEM
                     GEGKYYADLNVKMAQFELTLLDWAEAHKGARKYVAFADKCWPAFPSQFGFEPCYVNSRL
                     ASRGIPVSCEVDIYGALSEYIGLCISNDAVTLLDINNSVPQYIYDEDIKGKYDYKLTDT
                     FMGFHCGNTPACKMCDSRAVKYQLIQHRLLEPAGSEPDFTRGTLEGDIAASDITFYRLQ
                     CNSEGELVSYVAEGEVLDVPTRSFGGIGIFAIKEMGRFYRHVLIEGNYPHHGAVMFGHY
                     GKAFYEVVKFLGLDVKKIGYNQPAGVRYPTENPWG"
ORIGIN
        1 ccttttcgct ctctccaata gcatctgcaa ctttctcaaa tgcgttctgt gcttacgttg
       61 ccccatattt cccggcaccg ggacgggccg gcaagatcct cacacatccc ggatgaggct
      121 caaattctcc gggcatacga tattttgttc tgttcttctc tgtaacttcc atgtctgtct
      181 ccttttcttt gatagcccgg cagatatcag gaaagccggc tcttaaagtc ttcgtatccg
      241 aaatgtctga taacctcaca ctctccgtcc tcatgcataa ccgcaatatc cggcagcggc
      301 ataccgttaa atgtattatt cttcaccata gaataaatcg ccatatccat aaaatatagc
      361 ttgtccccga tccggatctc tctgtcaaag gaataatctc cgattacatc tcctgccagg
      421 caggtgcaag aagataagcg gtaggtatat gccttctccc ctgcttcccc gctgtcctta
      481 agaggcggac gatagggcat ctccagcaca tccggcatat ggcaggctgc agaagcatcc
      541 aaaatcagcg ttctgatctc attttccaca atgtccataa cctctgtcac cagatatccg
      601 gcattcaggg caacagcctc cccgggctcc agataaatat ccagatcata ggtttccttc
      661 atatgctgaa tacatttttc caggagcttt acatcataat cctctctggt aatatgatgt
      721 ccgccgccca tattcagcca ggaaacctca gacagaaatt ctccaaactt ctcctctacc
      781 gcctgcaatg ttttctccag gtcatccgca ttctgttcgc agagcgtatg aaaatgcagt
      841 ccgtcgatcc atttcagaca ttccccgtca aagttctctc tggtaacccc cagccttgaa
      901 cccggcgcac agggatcata gatcgcatga tccccctgag tggagcattc cggattaata
      961 cggagtccca gactggctcc ggtacacact tctttaaatt tcttcagctg tgctgtggaa
     1021 ttaaagataa tatggtcaca gatccgatcc agttcctcta tatcttctgt acggtaagca
     1081 ggggaaaaaa catgattctc tttccccatc tcttcatatc caagccttgc ctcaaacaga
     1141 ccgctggcag tggtacctgc cagatatttt ccgatcatgg gatacagagc aaagccggaa
     1201 aacgctttct gcgccagaag gatcttacac ccggtatcct cctggacttt tttcaaaatc
     1261 tccagattct cccgcatctt cttctcatcg atcacatagc agggagtttg cagttgatca
     1321 atcttcattg gctttccaga cctttaccag ttcaggatct tcgcagactt tccatggaag
     1381 tccccatttg ttcagtgctt ccatatatgg atccggatca aattcttcca cattaaatac
     1441 acccggcttc ttccactgtc cggtcactac catcatggaa ccgatcatag ccggaacacc
     1501 tgttgtatag gagattgcct gggattccac ctctttatag cattcctgat gatcacatac
     1561 attataaata taaatacttt tctcttttcc gtccttaaca cctgtgaaaa tacagccgat
     1621 atttgtttta cccactgttc tcggacccag agatgcagga tccggcagaa gagctttcaa
     1681 aaactggatc ggcacgatct cctgtccatt aaattccaca ggtgcggtgg aaagcattcc
     1741 tacattttcc agacatttca tatgtgtcag atagctctgt ccgaatgtca taaagaaacg
     1801 gatcctctgt actcccggaa tattttttgc cagtgattca atctcttcat gatgaagaag
     1861 atacatatcc ttctttccta cctcagggaa atcgtagaca gatttaaatt ccataggctc
     1921 tgtttctacc caatgtccgt cttcccagta ggaaccattt gcggaaacct ctcgaagatt
     1981 gatctccgga ttaaagtttg tggcaaaagg atatccatga tcaccgccat tacagtccag
     2041 aatatcaatg gtatggattt catcaaaata atgcttcaag gcataggcac tgaatacact
     2101 ggtaacaccc ggatcaaaac cggttcccag aagagcagtc agtcctgctt ccttaaattt
     2161 ctcatcataa gcccactgcc aggaataatc gaaatatgca gtaaagcctt tttctttaca
     2221 tctcttttca tagattgcac gccatgtggg atcttctgta tcctctgctt cataattggc
     2281 agtatcaata taatccgcac cggcttccag acatgcatcc atgatggtaa gatcctgata
     2341 tggaagtgcc acattcagga cagcatccgg cttataggct ctgatcaatt ctgcgacctc
     2401 tgctgcatta tccgcatcta cctttgctgt ctcaattttt gtcttcgttg tactttcaat
     2461 cttctctttg agtgcatcgc atttttcctt tgtcctgctt gcgatcataa tctctgtaaa
     2521 aacatcgctg ttctgacagc atttgcgaat tgccactgaa gctaccccac cacatccgat
     2581 taccaataat ctgctcataa actgttttcc tcctcttcca gtaaatcttc tacatatttt
     2641 ggaagcataa atgctcctct gtgaaggttt gttgtataat accatgtttc tatattaaga
     2701 ttatcaaacc tctccggcct gaaatcttcc agtggatgat atttctttga tgcaaatcca
     2761 aaaagccagt atcccgaggg acaggtaggg atatgtgcct gataaaccct gctcaccgga
     2821 aatgaccgga aaacctttct gtgcatcttt ctgcattcca cctcatcctc atcataaaaa
     2881 ggacttccat gctgataaac catgattccg tcatctctga gagccttata acagcttccg
     2941 tagaattcct ttgtaaaaag tccctctgta tgtcccagcg gatctgtgga atcattgatg
     3001 atcaggtcat atctggcctt tttattccgc aggaaccgaa ggccgtcttc ataataaatg
     3061 ttgactctct catccttcag tccctgggca atatccggaa acatctccgc acatacatcc
     3121 acaaacattt tatcggattc caccacatca atgctctcaa tctgtggata atggatcagt
     3181 tctctggcaa ctccaccgtc accgccgccg atgatcagaa cattttttac attgggatgt
     3241 actgtcattg gcacatgcgt gaccatttca tcataaataa attcatcctt gtcagaaaat
     3301 acgatctcac cgtccagagc cacaaatctt ccaaattctt cagactcaaa cacatcgatt
     3361 ctctgaaatt cactttcccc tgaaaataac tgtcggttaa tccggacaga aagctttaca
     3421 tttcctgtat ggaactcgga ataccataat tccatgatca gataccccct ttcaggacct
     3481 gaagattttc taccttcgga tcctccattc cctgcatgga acagcctttg tctcttgcat
     3541 aaagaatgta ttctacaatt tcctgtgtca ccatttcccc aggagcaaga atcgggattc
     3601 ccggaggata acacataaca aattcaccgc tgatcctgcc tgccgtctgt tccatgggca
     3661 gagattcttt ctccgcataa aacgcctgct gtggagacgc caccactgca ggtgcgatat
     3721 attccccgga aagcatacct gtgctgtcct tcttatacag acgttcaata tcagccaatg
     3781 cccctaccag tctctcaata tcctgaagcc tgtctccgat ggaaatgtaa gccagaatat
     3841 tacagatatc tccaaactcg atctgaatat catattcatc tctgagaaga tcataaactt
     3901 caatacctgc cagcccattt cccaatgtat aaatggagag ttttgtaaca tcaaaatcaa
     3961 aaacactggt tccattgatc agatccatac catatgcata atagccgccg atctcattga
     4021 tctcctctct ggcatactgc gccatccctg caaccttttc aaaggattcc tctcccctga
     4081 gtgccagatt tcttctggag atatccagac tggacaacag aagataagaa gcgcttgtgg
     4141 tctgagtcaa attgatgatc tggcgcactt tctctgcatt catactctta ttcaaaagca
     4201 gcagcgaact ctgtgtcaga cttccgccgg atttgtgcat ggaaactgcc gccatgtcag
     4261 cacctgccgc cattccggat acaggaaggt ttctgccgaa ataaagatgg gttccatgag
     4321 cctcatctgc cagcaccttc attcctcttg catgagcctt ctttacgata gtccgcagat
     4381 ccgaacagat tccataatag gtagggttat ttacaagaac cgccaccgca tccggattct
     4441 catccatagc cttctccacc tgactgactt ccatgccaag ggaaatgccc agctgcgcat
     4501 tcacctccgg gtttacataa accggaattg caccgcacag taccagggca ttgatggcac
     4561 ttttatgtac atttcgcggc agaatgatct tatcccctgc cttgcagaca gacaggatca
     4621 tgctctgcac tgcagatgtg gttcctccta ccataaggaa tgcatgcgct gcgccaaaag
     4681 catctgctgc aagctcctcc gcttctctga tcaccgaaac cgggtggcag agattgtcca
     4741 gcggcttcat agaattaaca tccagcccca cacatttctc tcccagcaac tgtgcaagct
     4801 ccggatttcc tcttcctctt ttatgtcccg gcacatcaaa gggaacgact ctcttctttc
     4861 ggaaacgttc cagtgcttca tatatgggcg catgctgttg tctttcataa tccatttgac
     4921 atgttcctct tttcctgtcg tcatgtaccg gcaaatacag ttctatcatt cagcaattgt
     4981 atactgcctc aaaccggcac aatgattcaa ttatttctct atatatttgc tatatctgca
     5041 caaaaaaaga agcagataag ttcattcacc atctgcttct ctcatgatct atagaatttc
     5101 tcaggctctg tctctttata tactgaccgg atttcccgta taaatccgtc tgtatcctgt
     5161 gcctgttccc gtattctgaa atattcatga ctgctgtcgt cttcaatcgc tggcaaatat
     5221 atgctatgct cttattgacc gtttcacaag atgatgtgtg cttacgcact gattattata
     5281 aagtaatcaa cttataaaat ttgagcttct aactcaatca ataatgtggt gtctcccacc
     5341 cggcaactgc cccgcctgtc cgtatggctt aacattcaga aactgtctct gaatgtgagc
     5401 aaatatttgc atgaaaacga tagtgtcttt tcatactaaa gatgagaata acatatcttc
     5461 tgaactgttg tcaattccat tttccatatt ttgcacagtc tttacccgct ttttatattt
     5521 tcttcatttg tcagggaaaa ctgtgtttat tttttaacaa tttcttccct tgataaaacg
     5581 tattttcttt cattaccaag gattacgatt ctcttctctt atcaatttgc acaactttta
     5641 tccagtttac tcacattttt tgacgtttca acaaaaattt tcttgacatt tttttctcaa
     5701 aatgatatat tgtattcatc aattgaaaga accttcgagt actgacggaa agagtggagt
     5761 gcaaaccacg tggagtcgga ggtttgtggg agccgaccgt ctgggcagta tttgaaatat
     5821 tcagatactg gccttttttt ataactttca gggcagaaat caggaatacc aggcagaccg
     5881 gccaatactt ctttcaatta ataattgttg ctgatcgcgg agtgaacagc aacagaagtt
     5941 tttcatgtta tgcggaaacg aaaggagaaa aacaattatg ggatttaaat cagacattga
     6001 aattgcacag gaatgcgaga tgcttccaat tactcagatc gcagagaaag caggtattga
     6061 cgacaaatat ctggagcagt acggaaaata caaagcaaaa atcgactaca atcttctgaa
     6121 agaaagtgat aagaaggacg gaaaattaat cctcgttaca gctatcaacc caactccagc
     6181 aggagaaggt aaaactacta ctactgtagg tcttgcagat ggtatgcaga gacttggcaa
     6241 gagtgttatg gtagctcttc gtgagccatc cttaggaccg gtattcggtg taaaaggtgg
     6301 tgcagcaggc ggcggatatg cacaggttgt tcctatggaa gatattaacc ttcacttcac
     6361 aggtgacttc catgccattg gcgcagctaa caacttactg gcagctatga tcgataacca
     6421 tatcttccag ggcaatgcat taaacatcga cccacgtaag atcacatgga gaagatgtgt
     6481 agatatgaac gaccgtcagc ttcgtaacgt agtagatggt cttggcggaa agacaaacgg
     6541 tatgcctcgt gaagacggat acgacatcac agttgcatct gaaatcatgg cagttctctg
     6601 tcttgcaagc gacatcaaag acctgaaaga aagattatcc aagatcatca tcggatatac
     6661 atacggaaaa gtttccgagc agaaacctgt aacagcaggt gaccttcacg cagaaggcgc
     6721 tatgacagcc ctgttaaaag atgctctgaa accaaacctt gtacagactc tggaacacgt
     6781 tcctgcaatc gtacatggcg gaccattcgc aaacatcgct catggatgta actctgtaac
     6841 agctacaaag atggctatga agcttgctga ttatgcaatc acagaagctg gtttcggtgc
     6901 tgaccttggt gctgagaaat tccttgatat caaatgccgt atggctggtt taaaaccaag
     6961 cgcagttgta atcgtagcta cagtacgtgc cctgaaatac aacggcggcg ttgctaaagc
     7021 tgaccttaac aatgaaaacc tggaagctct tgaaaaaggt atcccgaacc tgttaaaaca
     7081 cgtttccaac atcaaaaacg tatacaaact tccatgtgtt gttgctatca acgcattccc
     7141 tacagataca aaagcagagc ttgactttgt agaagctaaa tgtaaagaac tgggtgttaa
     7201 cgttgctctt tctgaagtat gggcaaaagg cggcgaaggc ggaatcaaac ttgcagaaga
     7261 agttatccgt cttgttgaag aaccaaacga cttctcctat gcatatgaac tggaaggttc
     7321 tatcgaagac aaactgaacc agatcgttca gaaagtatat ggcggtaaga aagtagttct
     7381 gacagctaac gctcagaaac aggcgaaaca gttagaagct cttggattcg gcaactgccc
     7441 gatctgtgta gctaagactc agtacagctt aacagatgac cagaccaaac tgggtgctcc
     7501 tactgacttc gaagttacag tacgtaacct gaagatttcc gctggtgcag gattcatcgt
     7561 agctcttaca ggtgagatca tgacaatgcc aggtcttcct aaagttccgg ctgctgagag
     7621 aatcgacgta gacgagacag gtaagatcac aggtctgttc taatcaggtt gaaatcaatc
     7681 gaataagtca aaaatataaa aatcatattt atatatgata tgtgtccaga cgattttaca
     7741 ggcgggaaga ttttcccgcc tgtttttttc tttatttttt tataagataa tcttttccgg
     7801 aaataccagg ttccgtcata tggatcggat ccagaatgcg attaagttca tcctcgtcca
     7861 taagcttttc tttcaaaatc agacttctta cagattcgcc tgtcttaatt gccttttttg
     7921 caatatccgc agccttctga tatccaagat gggggctgat tgcagtgata atacctacac
     7981 tgttttctac cagataacgg catctttctt catttgccgt aattcctaca atacaattat
     8041 ccaccaatgt ctggactgca tagccaagag tatcgataga ctggaacatg caatagaaaa
     8101 taatcggctc aaacgcattt aattccagct gaccagcctc tgcagccatg gtaatggtaa
     8161 catcattacc aataatatta aaagcaacct gattcactac ttcaggaata accggattaa
     8221 ctttacctgg cataatagag gaaccattct gttttgccgg aagattaatc tccccaaaac
     8281 cagtacgtgg accggaggac atcagacgga gatcatttga cattttggaa agagttaccg
     8341 cacatgcttt cacagcaccg gaaacggcta caaatggatc cagattctga gtggaatcaa
     8401 tcagatcaaa agcctgtata aagtccattc ccgatatttc agtgagattt ggaacaattc
     8461 ttctcagata gccctcatct gcattaattc ctgttccaat agcagtacct cccatattaa
     8521 gagtccgcat ttcatccatt gctttatcca ttctgtggat atcacgcatg attgctaccg
     8581 aatatgcctt aaattcctgt cccagacgaa ttggtactgc atcctgcatc tgtgtacgcc
     8641 ccatttttat tatgtgatca aactctgtag ctttttcatt aagagcatca tagaggcgaa
     8701 gaagctgttt tttcagattc tgcaacaaac gaagagaagt cattttaccg gcagtaggaa
     8761 taacgtcatt ggtagactgt ccacaattca catcatcgtt aggatttata attgtataat
     8821 cgcccttttt tcctcccagt atctcaatcg cgcgatttgc aattacttca ttggcattca
     8881 tatttaaaga tgtgccagct cctccctgaa caggatccac aataaattca ttatggaatt
     8941 ttcctgaaac aatttcatca catgcctgga caatcgcctg tgcttttttc ttctcaagaa
     9001 gccccacctc acaattggtt atcgctgctg ctttttttat gtatgcaaga ctgttaataa
     9061 tttccggatg catattcagc cccgtaatgt ggaaattttc agccgcacgt aaggattgta
     9121 ctccataata tacatcttcc ggaatatcct ttacaccaat agaatccctt tctacacgat
     9181 agtctgtttt tttcatagtt attcgccctc ccatgtattt gccctcatta tatatctctg
     9241 ctataatata atcaaataca tatattttta taaaatatat agtgtttaag ttatatatcg
     9301 gaggagttta tatgtttcag ggaatggaat acatctatga ggtctacaag gaaaaaagct
     9361 tttccaaagc tgctgctgct cttttcattt cgcagccttc tttaagtgca aatgtaaaac
     9421 gtgtggaaaa ccgcattggt tatcctattt ttgatcgaag taccaaacct ttacagttaa
     9481 ctgaagtcgg aaaacattat atacaggctg ttgaaaaagt catggatatt gaaaataatc
     9541 tcgaaaacta cctactggat ctaggaaatc tcaaaacagg aactcttaat gtaggtggca
     9601 gtaacttttt ttcttcgtgg attctgcctc cccttattgc tgatttttcc caaaaattcc
     9661 cccatgttca aatttctctt gtagaagaaa gtacagcaaa gctatcccag tttctccagg
     9721 ccggaaagtt agatctggta attgataact gtattctgga taaccagatt tttgaacatt
     9781 atatctacca gaaagaacaa cttcttctag cggttcccaa aaattattca gtaaataccc
     9841 gactgcagga atatcagatt cctattgagg aaatccggaa cgaacagttc cgttcttctc
     9901 atattccttc tgttccatta aacaaattcg agaacgaacc atttattatt cttcgttcag
     9961 ataatgatac cggtaagcgt gcacttacca tttgtcagga aaatcacttt tcgccttctg
    10021 tagtatttcg cctggatcag cagatgactg cctataatat tgcatgtttg ggaatgggta
    10081 tcactttcat cggggatctt ctgctctcca gagttccaac aaattcagaa cttgtttttt
    10141 ataagctacc cggtcagagc agtaaacgca ctgtgttttt ttactggaag aaaggccgct
    10201 atatcagcag agccatggaa gaattcctga agctgccctt ttcctgatat gtcataatca
    10261 aataggttat ggtgattggt catcatcaga tgtacgtcaa aatggggttg ttgtgctaaa
    10321 taagcacaac aaccccagta tgtcaggcag atattcgatt agaacaatgg cttcatcgcc
    10381 ggatacagag ttctgaactt ctgatatctc tcttcatatt ttgcaaccag ttcaggatcc
    10441 ggttctactg tatcaacaac tttggcaaat ttcttaccga tggtttctac atccgggtaa
    10501 gcaccacagc ctactgctgc cagcatagct ccacccatgg acggtccttc ttcgttctcc
    10561 agaacatcaa ccttcaggtt cataacgttt gcaatgatct tcttccacag tgggctctta
    10621 gctccaccac cgcagatctt ggttctctca atcttgattc caaggtttct tgcaacttcc
    10681 agggaatcac gaagaccaaa ggcaacacct tccagaacag cctgtgtcat gtctgctctt
    10741 gtgctgtcca tggacattcc gaagaataca cctcttgcat caggattatt atgaggtgaa
    10801 cgttctccca tcaaatatgg aaggaagaat acatgattct ctcccagctt ctgaattgga
    10861 gcctgctctg ctgcgaaatc ctttgtctga agaatctcct ctgcccacca tttgttacag
    10921 gaagctgcgc tgagcatgca tcccatcaga tgatagcttc catctgcatg acagaaagaa
    10981 tgaagtgcgt tattttcgtc cacaccaaag tttttactgg aaataaacac agttccggat
    11041 gttccaagag aaatattaca ctgaccgtca ccaactgtac ctgttcctac agcagctgcc
    11101 gcattgtcac ctgcacctgc aacaactttt acattctcac tgaatccaag ttctttcgca
    11161 atctcaggtt tcagagttcc tactacttcc caactctcat acagtttcgg aagctgctct
    11221 tctgtgattc cacagatctc cagcatttct tttgaccagc agcggttctt cacatcaaga
    11281 agaagcatac cggaagcatc agaaacatct gtacaaaaag aaccggacag acgatatgcc
    11341 agataatcct taggaagcat aatctttact accttcttaa agttctcagg ctcatttttc
    11401 tgcatccaga ggatcttcgg tgctgtgaag cctgcgaaag caatatttgc tgtatactgt
    11461 gaaagtttgt cttttccgat cactgtattc agatattctg tctcttcgcc tgtacgtccg
    11521 tcattccaga ggattgcagg acggatcaca ttatcatcct tgtcaagtgt taccagacca
    11581 tgcatctggc cgccaaaacc aattcctgct acctgcgctc tgtcgatatc ctttgtcagc
    11641 tctttcatac cttccatact ctgtgcaaac cagtcttccg gtttctgctc agaccagccc
    11701 ggatgtggga agaataaagg atattctctg gatacgatgt tacagatttt tcctgattct
    11761 tccataagaa gaagttttac agcggaagta ccaaggtcaa taccaatata atacataagt
    11821 gctctccttt tctatttcta atctaataca tcccagagca aagccccggg atgcctttaa
    11881 tatagtgtca gtttatttat tctgtattca gattcattca cttcacatga acattaataa
    11941 tccgttttac tgatttctca ttaaccccat ggattttctg tcgggtatct tacacctgcc
    12001 ggctggttat atccaatctt cttaacatcc agtccaagga atttcactac ctcatagaat
    12061 gcttttccgt aatgtccaaa cataactgct ccatgatgcg gatagttgcc ctcgatcagt
    12121 acgtgacggt agaatcttcc catttctttg attgcgaaaa taccgatacc accgaatgat
    12181 cttgtaggta catccagtac ttcaccttct gcaacataag aaaccagctc gccctcggaa
    12241 ttgcactgta aacgatagaa tgtaatgtca gatgcagcga tatcaccttc aagagttcct
    12301 cttgtgaagt ctggttcaga tcctgccggc tcaagaagtc tgtgctggat cagctgatat
    12361 ttaacagctc tggaatcaca catcttgcat gcaggagtat ttccacaatg gaatcccata
    12421 aatgtatcag taagcttata atcgtatttt cctttaatat cttcatcata gatatactgt
    12481 ggaacagagt tgttgatatc aagcagtgta actgcatcat tggaaatgca aagtccgatg
    12541 tactcgctga gtgctccgta gatatcaacc tcacaggata ccgggattcc tctggaagcc
    12601 agacggctgt ttacatagca aggttcaaat ccaaactgtg acgggaatgc tggccagcat
    12661 ttgtcagcaa atgcaacgta ttttcttgct cccttatgag cctctgccca gtcaagaagt
    12721 gtaagctcaa actgtgccat tttcacatta aggtcagcat aatatttgcc ttcgcccatc
    12781 tctttggcca tatctgcaca aacttccggg atacgagggt cattttcatg ctctttgaaa
    12841 gaaacaagaa gatcaagctc tgagttctct tcaatctcaa cgcccagctc atagaggcct
    12901 ttaataggtg cgttgcatgc gaagaagtcc tgtggacgcg gtccaaaagt aatgatctta
    12961 agattgctga caccgatgac tgcacgtgca accggtacga aatcagcgat catctttgca
    13021 atatcatctg ctgttccaac aggatattcc ggaatatatg ctttcagatg acgcattttt
    13081 aagttgtagg agcagttaag cataccacag taagcatcac ctctgccgtt gatcatatcg
    13141 ccgtcacctt ctgctgctgc tacatacatg caaggtccgt caaatctctc tgcgatcaga
    13201 gtttcaggag tttcaggtcc gaagtttcca aggaaaacaa ccagcgcatt acactctgct
    13261 ttgtttacat cttcaagagc tttctccata tccttttcat tctcaacagt tacaggacat
    13321 tcataaagtt cacctttata agtttccttg attgctgcac gtctcttctc agaaagctga
    13381 atcggaaaac agtcacggct tactgcaatt aatccaagtt ttactactgg tatattgttc
    13441 ataatataaa ttcct
//
