LOCUS       c00023_gnlPro..         9826 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AKDGHAFL_23.
ACCESSION   c00023_gnlPro..
VERSION     c00023_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:15:03
            Original ID  :: gnl|Prokka|AKDGHAFL_23
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9826
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9826
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5387:8615]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5388..8615
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..9826
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..9826
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             107..1444
                     /locus_tag="ctg23_1"
                     /transl_table=11
                     /translation="MKKFLTALIAFVMCFSVVTTAFAATPDEASDSDLISNIKQAMLDT
                     YYGDEKPEYLNVEILLDDEDEVYFSFSDSFATSANRVYTEAGNYIVSYLENCPVALYKN
                     NRVYMIPDAYNSGVIDDDTLEGLTYCGHMDIVPKSDDSALVIEIKNKVIEECFDGKSPE
                     TLRIDIVGRTSDGGVYYRHEYGFALGVIIEEKFGDCTYSYTHGNDVMLYKNNSVYSIKN
                     AYESGIIDDKIVNELVKMNIGIIPDKDVSTLKQLTLKMCQNAGYTDLAEDDIDIWRIIY
                     LSDDRIMFTFNVSGADIPESPVKEVIGNYTFIGERQLYIYADGQIYTLKEAFDAGIIDN
                     DDLAFFADDWKDDISFSIVLNPTQPDTTAPTTSTTTPDEPATSPAATSATKPVSTSDTA
                     TNDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNHFE"
     CDS             1638..2651
                     /locus_tag="ctg23_2"
                     /transl_table=11
                     /translation="MKKLLTALIAFVMCFSVVTTAFAATPDETSDPDLISDIKQAMLDT
                     YYGDEKPDFIEVRIYGTASDGGVYFDFMDSFTHWTDEVEFDIGDYTVSYPRDCPVLLYK
                     NNKVYTLSDAYETGVIDDDMLYELYVWGNLWGKIDVTPKGEDRALLSEIKRVIINKYYN
                     GKAPEYLNVEIVGSTSDKTVCFRNIPFMSLGVMIEQTIGDYTYYYNHGDDVMLYKNGNV
                     YSIKEAYESGVIDDSILEELSKMNFGLESNKPNTTVPTEPTTSVATVDEPVTVPDTTSA
                     TKPVSTSDTATNDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNYFK"
     CDS             2848..4989
                     /locus_tag="ctg23_3"
                     /transl_table=11
                     /translation="MKKFLPIAMAAVMSMSAVVVSAVSANAVEPLNTPVQYAQVARASL
                     ATPKISKAESVYGGVKLTWNKVNGAAKYRVYYKGRKGWTRMVDTTSTSYIDKDVSSGRN
                     YTYTVRCISADGKSFTSGYDSKGKSVKYIAAPEISKLENVNGGVKITWNKVNGASKYRI
                     YHKNSSDWFRVSDTTSNSIVDKSVGMGTYTYTVRCISDDGKSFESGFNPKGSSIRYIQA
                     PKILETNVVNGGIKVIWDSEENTNYRLYCKTEGKGWTKVCDSKTGVVTHKNLQPNKTYT
                     YTVRAISSDAKKYLSGYDPVGMSAKYVATPKISKTEVTYDGVKLTWNKVAGAEKYRVYY
                     KDGEGWNKLADTTGNSYLDMGLVSRELSIKDNSVNGQYIYTVRCISSNGKVFQSGYDTK
                     GSKANLGNECPEIVRVDSMHGGITVSWTDVCEDNSKYRIYVKEKGSWKKLADTTNNYYT
                     HKNVKAGQTYTYTVRCVSKDGKKFTSIYNPSGVTFKYKTTDKTRDAYIDYLLKHESEWL
                     PELKVGNVALAGVQFADLDFDGVPELIVQEAGDKEYYLNAKVYTFKDGKFSLVGFDDYR
                     TYIPNQLTYFYDKSAKKYIINAVELSTSNVDRYLERENYTLNYDGTVLVVRGYSSAHLA
                     LESRGLEYHYYNNTGRTTKQAYNATNVSVLGNCVNAHMYSQFVYCSVDGYPKLWNNYSE
                     TQKKQHLLDSYNAFSYDKY"
     CDS             complement(5388..6428)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_4"
                     /sec_met_domain="IlvN (E-value: 4.3e-84, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.4e-61, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(6489..6980)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_5"
                     /sec_met_domain="ALS_ss_C (E-value: 2.4e-30, bitscore:
                     93.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRVNTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(6993..8615)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg23_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKIYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(8812..9825)
                     /locus_tag="ctg23_7"
                     /transl_table=11
                     /translation="IDNGFIYSKINKDSPNEMEYYRYYLDKKNSVKLGSIKNWSMQIHD
                     KAYVNNHLCFTTSTGDITDEENRTLEFIDIDLNKNKMTTVFSDKGGFPYDTVTGADNLV
                     IITKVLDNGTSLELYDTETQKFKQLKYLEFDDKNSIGETIRKVSIDKSTKTISLLVLDC
                     ISQNEASLKIETYDYDMNFLKSYDISNISDDSNELIQGVQVFDFKNNYLFYQNFSITRC
                     IGYIDSDKLKKSDISEDVDDTFSIVSASEDDSDTNLLYKRAESSSENNYIYLFDTTNKT
                     MKETKFNIEEKGYTIGGISRIGKDNLMILMSPDNADKKSDLNSRIYFTKLSDLNFQ"
ORIGIN
        1 aactatattg cattacatat attttagcgg tataatgatg taaattgaat atctgttgca
       61 tataccatta ttacagatag aataaataaa agatgaggaa ataaaaatga aaaaattttt
      121 aacagcattg atagcatttg taatgtgctt ttcggttgta acaacagctt ttgcggctac
      181 accggatgaa gcttctgatt cagacttgat ttcaaatatt aaacaggcta tgttagatac
      241 atattatggt gatgaaaagc ctgaatatct gaatgtcgaa attcttttgg acgatgaaga
      301 cgaggtttat ttcagttttt ctgacagctt tgctacttct gcaaacagag tttacaccga
      361 ggcaggcaat tacatagttt cttaccttga aaattgtcct gtggcactgt acaaaaacaa
      421 cagggtttat atgatccccg atgcttataa ttcaggcgtt attgatgacg atacacttga
      481 gggcttgacc tattgcggac atatggatat agttccgaaa agcgatgatt cagcacttgt
      541 tatcgaaata aaaaacaaag ttattgaaga gtgttttgac ggcaaatcac ctgaaacttt
      601 gagaattgat attgttggca gaacaagtga cggcggagta tattatagac atgaatacgg
      661 ctttgcactt ggtgttataa ttgaagaaaa atttggtgat tgtacatata gttatacaca
      721 cggaaacgat gttatgctct ataagaataa cagtgtttat tcaattaaaa atgcgtatga
      781 gagcggaatc attgatgata aaattgtcaa tgagttagta aaaatgaata ttggtattat
      841 tcctgataaa gatgtaagta cacttaagca gttaaccctg aaaatgtgtc aaaatgcagg
      901 ttatactgat ttggcggaag atgatattga tatatggaga attatctatt taagtgatga
      961 ccgaataatg ttcactttta atgtatccgg tgctgatatt cccgagagtc ctgtaaaaga
     1021 ggttatcgga aactatacat ttataggcga gcgacagttg tatatttatg ctgacggtca
     1081 aatttacaca ttaaaagaag cttttgatgc gggcataatt gataatgatg acttggcatt
     1141 ctttgctgat gattggaaag atgatatttc tttcagtatt gtccttaatc cgacacagcc
     1201 tgatacaaca gctccgacaa catcaacgac aacacctgat gaacctgcta catcacctgc
     1261 cgcaacttcg gcaactaagc ctgtttcaac aagcgacaca gctacaaatg acacaccgaa
     1321 caattcacag aacaacagcg gtgctgtaca gacaggacag aacagcgttg ctgtaattct
     1381 tcttgttgca atgcttgcag gttgtgcagt aatttttgca aaacgcagaa atcattttga
     1441 gtaatttaca aattaaataa tccctataaa agccgttctc gttattgaga gcggttttta
     1501 ttttgctgat tattttatgt gaatttttag caactatatt gcattacata tattttagcg
     1561 gtataatgat gtaaattgaa tatctgttgc gtataccatt attacagata gaataaataa
     1621 aagatgagga aataaaaatg aaaaaacttt taactgcatt gatagcattt gtaatgtgct
     1681 tttcggttgt aacaacagct tttgctgcta cacctgatga aacttctgat ccagacttga
     1741 tttcagatat taaacaggct atgttagata catattatgg cgatgaaaag cctgatttta
     1801 ttgaagtaag aatatatggt acagccagtg acggtggcgt gtatttcgat tttatggata
     1861 gttttacaca ctggacagat gaagtggaat tcgatatagg tgattatact gtttcttatc
     1921 cgagagattg tcccgttttg ttatacaaga ataataaagt atataccttg tcagatgcct
     1981 atgaaacagg tgtaattgat gatgatatgc tctatgaatt atatgtttgg ggaaatcttt
     2041 ggggtaagat agatgttacc ccaaagggtg aagatagagc tctcctttca gaaataaagc
     2101 gtgtaattat aaataaatat tacaatggca aagcacctga atatttgaat gtcgaaattg
     2161 ttggttctac aagtgataaa acagtatgtt ttagaaatat accctttatg agtttaggcg
     2221 ttatgattga acaaacaatt ggtgactata cttattatta caaccatggc gatgatgtta
     2281 tgctttataa gaatggcaat gtttactcaa ttaaagaggc ttatgaaagc ggagttattg
     2341 acgatagtat tcttgaagaa ttgtcaaaaa tgaattttgg tttggaatct aataaaccga
     2401 atacaactgt tcctactgag cctacaactt cggttgcaac agttgacgaa cctgtaacag
     2461 tacccgatac aacttcggca actaagcctg tttcaacaag cgacacagct acaaatgaca
     2521 caccgaacaa ttcacagaat aacagcggtg ctgtacagac aggacagaac agcgttgctg
     2581 taattcttct tgttgcaatg cttgcaggtt gtgcagtaat ttttgcaaaa cgcagaaatt
     2641 attttaaata attcaaaaca tcaacagaat atataaaata aaccgttctc gcttttgtga
     2701 acggtttatt tattttagct taaaaatttg tgatagttta tcaagatgta ttgcttttta
     2761 tatcatttaa tgttacaatt aacttgcata aaaatttagc aaaagttctt aataatgcgt
     2821 agaatattta caaagtgagg gataactatg aaaaagtttt tacctatagc catggcggcg
     2881 gtaatgtcga tgtctgcggt tgtggtttcg gcagtttctg caaatgcggt tgaaccgctt
     2941 aacacacccg tgcagtatgc acaggttgca agggcaagct tggcaactcc gaaaatttca
     3001 aaagccgaaa gcgtttacgg tggtgtaaag cttacatgga acaaagtgaa tggtgcggct
     3061 aaatacagag tttactacaa gggccgtaaa ggttggacac gaatggtcga tacaacttca
     3121 acctcatata tcgacaagga tgtttcatcg ggcaggaatt acacctatac tgtaagatgt
     3181 atttctgctg acggaaagag ctttacaagc ggttatgatt caaagggcaa aagtgtaaaa
     3241 tatattgccg cccccgaaat ttcaaagctt gaaaatgtaa acggcggtgt gaaaattaca
     3301 tggaacaaag taaacggtgc atcaaagtat agaatttatc ataaaaattc gtcagattgg
     3361 ttcagagtat cagatacgac ttctaattct atagttgata aatctgttgg tatgggaacc
     3421 tatacttata ccgtgaggtg tataagtgat gacggaaaga gttttgagag tggatttaac
     3481 ccaaaaggct caagtatcag atatattcaa gctcctaaaa tacttgaaac caatgttgta
     3541 aacggcggta ttaaggtgat ttgggattct gaagaaaata caaattacag attgtactgc
     3601 aaaacagaag gtaagggctg gacaaaagta tgcgatagca aaacaggtgt tgtgacacat
     3661 aaaaatttac agccgaataa aacctataca tacactgtaa gagcaatcag ttccgacgct
     3721 aaaaagtatt tgagcggtta tgaccctgtg ggaatgagcg caaaatatgt tgccacaccg
     3781 aaaatttcaa aaactgaggt cacatatgac ggcgtaaagc tgacatggaa caaggttgca
     3841 ggtgcagaga agtaccgtgt gtactacaaa gacggtgagg gttggaacaa acttgccgat
     3901 acaacgggta acagttatct tgatatggga cttgtatcaa gagaactaag cataaaagat
     3961 aattccgtaa acggtcagta tatttatact gttcgttgca tttcaagtaa cggcaaggtt
     4021 tttcagagcg gttatgatac aaaaggttct aaggcgaatt taggcaatga atgtccggag
     4081 attgttcgtg ttgactcaat gcatggcgga attacagttt catggacaga tgtttgcgaa
     4141 gataattcaa agtatcgtat ttatgtaaaa gaaaaaggtt cgtggaaaaa gcttgctgat
     4201 acaacaaata attattacac tcataaaaat gtaaaagcag gacagaccta cacttatacc
     4261 gtaagatgtg tttctaagga cggcaagaaa tttacaagta tctataatcc gtcaggtgtg
     4321 acatttaagt ataagactac agataaaaca agagatgcat acatagatta tctgctcaag
     4381 catgaatcgg aatggttacc tgaactcaag gtaggaaatg ttgctttggc tggtgtgcag
     4441 tttgccgatc tcgattttga cggtgttccc gagcttatag tacaggaggc aggagataag
     4501 gaatactatt tgaatgcaaa ggtgtatacc tttaaggacg gaaagttctc gttagtcgga
     4561 tttgatgatt atagaactta tatcccgaat caactgactt atttctatga caaatctgct
     4621 aagaaatata taattaatgc cgttgaattg tcaacctcaa atgttgaccg ttatcttgaa
     4681 cgcgaaaact atacattgaa ttatgatggc acagttttgg ttgttcgtgg atactcttct
     4741 gctcatttgg ctcttgaaag tcggggattg gaataccatt attacaataa taccggaaga
     4801 acaacaaaac aggcatataa tgccacaaat gtgagtgtac tcggtaattg tgtaaatgca
     4861 catatgtaca gtcagtttgt ttactgttct gttgacggct atccaaaact ttggaataat
     4921 tatagtgaaa cacagaagaa acagcacctt ctcgattcat ataacgcttt ttcttacgac
     4981 aaatattgat tgtcaaaatt gataagtttt aactgcaaaa gggttcagcc gcaaaaagct
     5041 gaaccctttt attgcacaac aaaaaacggt tcagccaaat tgactgaacc gttaattcat
     5101 actatgttaa gcttgggaac cagtagttgt aaattatcac aaactaccta cacaaactgc
     5161 gagcgaggta ctcgcaaaaa gggtagcttg aaagttataa ctatgttaag ctcgggaata
     5221 agtagttgta aattatcaca aactacctac acgaactaag agcgaggcac tcgcaaaaag
     5281 ggtagcttga aaatcaagct accctaaatt cgtactatgt aatgctcggg tgacagaagt
     5341 ttgaatacat caaactgtct tcacgaactg tgtgcgagac actcgcatta gttgttgatg
     5401 agcttatctt cgtcagacca gctgtagagc tttctaactt ccttaccgaa tacttcggca
     5461 ggagcttcgg cagcgagctt tctcatagcc ttgaagtgaa cctgtgaacc ggcatcgctc
     5521 atgtcaagga ggaagtcctt agcaaatgta ccgtcctgaa tgtcagaaag aacctttctc
     5581 atagccttct tagtatcctc tgtgatgatc tttggacctg tgatgtagtc accgtactca
     5641 gctgtgttag agattgaata tctcatgcct gcaaaacctg actgatagat aaggtcaacg
     5701 atgagcttca tctcatggat acactcaaag taagcatttc ttgggtcgta accggcatcg
     5761 caaagtgttt caaaacctgc ctgcataagt gcgcaaacac cgccgcaaag aacagcctgt
     5821 tcaccgaaga ggtctgtttc tgtttctgtt ctgaatgttg tttcaagaac acctgctctt
     5881 gcaccgccga taccgagtgc atatgcaagt gcgagatcct tagcctgacc tgtagcatcc
     5941 tgctcaacag caacgaggca aggtacaccc ttaccaacct gatactctga acgaactgtg
     6001 tgacccggtc ccttaggagc taccattgta acatcaacat cctttggagg cttgatgcaa
     6061 ccgaagtgaa tgttaaagcc gtgagcaaac ataagcatgt tgcctgcttc gaggtttggc
     6121 tcgatgtcgt tcttgtaaag agctgcctgc ttttcatcgt tgataagaat catgatgatg
     6181 tcagcctgct ttgcagcctc tgccgatgta tataccttaa agccctgtgc ctcagccttt
     6241 gcccagctct tgctgccttt gtaaagaccg atgattacat cgcaacctga atccttgagg
     6301 ttgagagcgt gtgcatgacc ctggctgccg taaccgataa tagcaatttt cttacccttg
     6361 agaaggtcaa ggttgcaatc tgactgatag tagattggtg ctgtcatgtt ttttgtgtag
     6421 tctttcatat taaagtcctc cttaccgcaa acgcggcata taaattaaaa tatatgctaa
     6481 ctgtaagatt aaacggaaac cgaagctgtg cctctgtcga tggcaacagt acctgttctt
     6541 acaatctcac ggataccata aggcttgagt aagtcaacaa gcgtgttgac gcggcttgca
     6601 cattcgcagt actcaacggt aactgacgaa ggggatacat caacgatttt tgcctgcata
     6661 atttcaaccg ttttgacaat ttcggctctt tttgaggcgg cgcagtgaac cttgattaaa
     6721 acaagctcac ggctgataaa ttcgccctcg ttaagccttt ttactttgat gacgggaatg
     6781 agcttgttga gctgtttttc aagctgttca acaatgtact cgtcaccgtt tgcaacgatt
     6841 gtgattcggg aaaccgacgg gtcctgagta acacctactg cgagtgagtc gatgttaaaa
     6901 cctcggcgag agaaaagtcc cgaaattttt gaaagaacgc ccgcctgatt ttcaacaagt
     6961 attgataatg tatactgcat tttatcacct cattaaattg acggagtgtc ggggtgaaca
     7021 tcgcaaacaa gaatgaacgg tttttccgaa tcaacaatac ccttgatgat gttttcggct
     7081 tccttgtttg aatgagcctc tgcatggtca atgccgtaag catcggcaat cttcaagaag
     7141 tcgggatcac cgttgagaat tgttgcggag tgtctgccac cgtagtgttt gtcctgaagt
     7201 tcacgaacca ttccgagtcg tgcgtttttc ataatgatga ttttaattcc gagctgattg
     7261 cctgcaatag tcgcaagctc attaagcccc atctgaaaac tgccgtcacc gcagattaca
     7321 ataacatcac ggtcgggtct tgcaaacttt gcaccgattg cagcgggaat tgagtaaccc
     7381 attgtaccca taccgcctgt tgtgaggaat ctgccctcac gaatacggaa gttgtttgca
     7441 caccagattt gattttgtcc tacatcggca acgagaattg cctttgagcg gaacattgca
     7501 ctgagatgac cgacaagtgt tctcggctca acaaagccgt caaatacggg aggttcacgg
     7561 taaaggtctt ttttccagtt ctttacggtt tcgctccaca ttgttgtaac cttgtaatcg
     7621 ccgatgctgt caagcagcat attgatgaca tttttcatat cgcctacaat cggaatttct
     7681 gttttaacat tcttaccgat ttcagcaggg tcaatgtcaa tgtgaattac ctttgtgttt
     7741 tcactcatct ggtcgggagc cgcaacagct ctgtcaccga gtcttgcacc gcatacgatt
     7801 acaaggtcgg cttcgtgaag agcacggttg gcaacagcct tgccgtgagt gccgagcatt
     7861 ccgagataaa gctcatgctc gctgggcata acaccgatgc ccatcatagt tgaaataacg
     7921 gggatacccg tagtttctgc aaatttttga agtttaagct tgatacccga actcagcacg
     7981 ccgccgcctg atacgataac aggacgcttg cttgcgttga tggcctcaac agccttttta
     8041 acctgaattg cgtgtccctt agtgttcggc ttgtaaccga taatgtttac gctttcggga
     8101 tattcaaaac tttcaatttc attttcctga atatcaacgg gaatgtcgat aagtacagga
     8161 ccgggtctgc cggttgaggc aatatggaaa gcctctttga aaactctcgg aaggtcttct
     8221 gttttgctga cgagataact gtgctttaca aacggttcac aagctcctgt gatgtcagct
     8281 tcctgaaaga catctctgcc gagaaggtcg gaacgaacct gacctgtaat ggcaacaatc
     8341 ggaatagagt ccgtataggc ggttgcaatg cctgtgatga ggttggttgc accgggaccg
     8401 gaagttgcca cgcaaacacc gggacgatta ctgcatcttg catagccgct tgccgcatga
     8461 gcagcgttct gttcctgacg aacaagaatg tgggtaatgc tcgagtcgta aattttatcg
     8521 taaaatgggc aaatagccgc accgggataa ccaaagacta tgtcaacgcc ctcggcttcc
     8581 aaacatttta ccataatttc agcaccgctg atcattatgt tttgtccctc ctatcctttt
     8641 tattgtgagc aaaaggtgtt ttgtaacatt aaatatacct ttttacttta ccgctaatta
     8701 tacaataaat accttaaaaa gtaaagagca gtattgccca taaattaaat tttttgcagg
     8761 attttgacag ataatttgca aaatgaattt taattgattt ttaccgcctg tttactgaaa
     8821 atttaagtcg cttaattttg taaagtatat tcttgaatta aggtcacttt ttttgtctgc
     8881 attatcaggg gacatcaata tcatcaaatt atcttttcct atccgtgata taccgcctat
     8941 agtgtaccct ttttcttcaa tattaaattt tgtttctttc attgttttgt tggttgtatc
     9001 aaaaagatat atgtagttat tttctgaact tgattccgcc ctcttataca ataaatttgt
     9061 atcactgtca tcttcagatg cggatactat tgaaaaagta tcatctacat cttctgatat
     9121 gtcggatttt ttcagcttat cgctgtctat atatcctata catcttgtta tgctgaaatt
     9181 ttgatagaat agataattgt ttttaaaatc aaaaacctgt acgccctgaa ttaattcgtt
     9241 tgaatcatct gaaatgttgg atatatcata gcttttgaga aaattcatat catagtcata
     9301 agtttctatt tttaaagaag cttcgttctg tgaaatgcaa tccaaaacca aaagagagat
     9361 tgtttttgta cttttgtcaa ttgaaacttt tcttatagtt tccccgatac tgtttttatc
     9421 atcaaactct aaatatttta attgcttgaa tttttgagtt tcggtatcat acagttccaa
     9481 agaagtaccg ttgtctagca cttttgtgat tatgacaaga ttgtctgctc ctgtaacagt
     9541 gtcatatgga aatccgcctt tgtcagaaaa tacagtcgtc attttgtttt tattaaggtc
     9601 gatatcaata aattcaagag ttctgttttc ttcgtctgta atgtcgcccg tgcttgtcgt
     9661 aaagcaaagg tgattattta cataagcttt atcgtgaatt tgcatagacc agttttttat
     9721 tgaaccaagt tttacactgt tttttttatc taaataatat ctgtagtatt ccatttcatt
     9781 tggagagtct ttattgattt ttgaatatat gaagccgtta tcaatt
//
