LOCUS       gnlProkkaCJENKGDL_143  16538 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJENKGDL_143.
ACCESSION   gnlProkkaCJENKGDL_143
VERSION     gnlProkkaCJENKGDL_143
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:38:37
            Original ID  :: gnl|Prokka|CJENKGDL_143
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16538
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16538
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6518:7109]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6519..7109
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     cand_cluster    1..16538
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16538
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(194..406)
                     /locus_tag="ctg143_1"
                     /transl_table=11
                     /translation="MSNEQQRHDISDEVWSLLEPHLPGQRGQWGGIAQDNLRFINCVFC
                     ILRTGAPWRDLLQFYGKWGTVYQRF"
     CDS             486..1049
                     /locus_tag="ctg143_2"
                     /transl_table=11
                     /translation="MDEILLYGAHGIIASSPPLLQLRVCAAYASVLTHRTLRTLNLAKP
                     QRMRFCCSHLQRRHGIMDDVMVLTLLYIGVFCPVKENIEIQATSFERIRPYRMNEASEN
                     GEVSAAIESMGKHGSINSYFYVKLSAQLLAQLPAFNTMKFLLSDGGSWNLIFYTGTANT
                     RIFSQQKKWKSYAQLMASSSIIDI"
     CDS             complement(1063..1167)
                     /locus_tag="ctg143_3"
                     /transl_table=11
                     /translation="MWRAVIVVGIVFALLAYACIVVGARSEDNRAGGN"
     CDS             complement(1736..2218)
                     /locus_tag="ctg143_4"
                     /transl_table=11
                     /translation="MKYNHAMAEREYKREWKAAKLEMRKAGMQRKQIREAARAYRLEFN
                     GERRFYRRTDVVPACEREDRPPKGVDTLFQESHSMHSPDLEDDIGELIDQVERSDRLSR
                     LRSLTEQQYRVVELYTEGYATSDIAQILSLDNQTVLNHKNRAVQKYKSIIPKVSKG"
     CDS             2642..2935
                     /locus_tag="ctg143_5"
                     /transl_table=11
                     /translation="MNDKLYRDIGKRIKLARRACSITQERLAEMVGVTNQHISNIEVGN
                     KAPSYELLYAIAEKPNCSAYSLLPAESSNSGKYFSEEIMHLLQSTPFLLPFT"
     CDS             2995..3252
                     /locus_tag="ctg143_6"
                     /transl_table=11
                     /translation="MAAVNKDGLYSTVEILLMDEPQTVLLDNEYSDYYRISFGSNDALW
                     TCHESGNNILTWADQNVLYQVTTAASLNEAIYIAENIEMG"
     CDS             3386..3814
                     /locus_tag="ctg143_7"
                     /transl_table=11
                     /translation="MKKFICIVLTVVLALSCMSAFAAEPLSSQEGGTTAQESITPFWVN
                     TLSIIPSISGSAGTYSCSINGVSGTTKISATLVLYEKGWLGGYTEVARTSHTTYSASFF
                     KSDSYSFSSGKTYKLEVSGTVTRNGYAEPVSATIEQKI"
     CDS             4424..5140
                     /locus_tag="ctg143_8"
                     /transl_table=11
                     /translation="MYQIAICDDEKIFTDKLAHMIKQYSNAHHHVIDLHLFQQAADFIQ
                     SSLESYDIVFLDVRFGEISGIEVAKALRAKNENAILIFVSAFIEYAIMGYSVHASAYLL
                     KSDLDGTFESCMDEIFPQIGSKEISVRVPYEHVNVDIPCKSIIYMESYKRQIQIHTSLP
                     RYPSILYYAKLSDMIETLAPHGFLRIHKSYLINLSRCRRIQNRLAYMDNSTELPCSRQN
                     YTDIVQKFLQWKEREI"
     CDS             5140..6429
                     /locus_tag="ctg143_9"
                     /transl_table=11
                     /translation="MEHLMEIMTTGTETFCIVLLLNTFFERKYTSYRFFFPLSAAFLFY
                     LWLPLNTILATSFVTKLFISILIWLVFSQIFYTGALPFHLFLLCSFFIILSGLDYFTLL
                     GISYIFSFSFSDALSNSALYILGAFVSRTLLLLFSIIIYRLFKAKTSMILSSSTWIALL
                     LFPVFSILLFGVTIEIAMAQNKISFNLILSGIGLLLFNISLFLLLGKLEYSTNLQQKNI
                     ALQHEIDQNMKSTNALQAIFNEQRALTHDFNNHITTLYMLLKAEHYEKATEYVKVLSQN
                     LPENTRVVSTNHPILDTILNQKYTQAKLQNTSMRFTVNDLSSFPMKDEDVVTLLGNLLD
                     NALEACRKLPDSSYINVKILKKEGDFLLSVENSSLPVKISENNYVPTDKAEPRLHGFGL
                     QNIAHIMQKYGYEYTLFYHDARFHFVSILS"
     CDS             6519..7109
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg143_10"
                     /sec_met_domain="AgrB (E-value: 1.3e-27, bitscore: 86.7,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLLLSYCERLTDFFISQCGLPETRRSWYIYALQTRISMFLSTAG
                     MMLLGCLVATPYQVICFLVGILSLRRRLGGYHAKTPLRCLFLSIGVSILCLSIVNSLVQ
                     YSLSILIWILFISLSFAVFNSSPYSHPNCPLTPDELAVSWIKAKHILIWNLLLILLLQI
                     FFAHSNCSLYCEMGIIAAAISFFVSKFKEVKSS"
     CDS             7106..7258
                     /locus_tag="ctg143_11"
                     /transl_table=11
                     /translation="MNKIATFLSEKLAGKLDDLARRDMREWPPTSVPIYYQPQRPQRKV
                     DNTDK"
     CDS             7348..7908
                     /locus_tag="ctg143_12"
                     /transl_table=11
                     /translation="MKKKLIVIVTCLVLAVAMAVPVFARYETYDIVRNDIDHIGYQMCL
                     SLYSTRGAYNNCRLSTWNYEGSSDQLWEAKYNSNTGAYTMCVQTDPNYALNAYRVLKND
                     WDGNYYQADVYPYYQNPDAAVTFIRNLSYSYIKNITTGYNLTVSGRKTPAQPTDADSTS
                     YYIDWYEKSFPVASEWRAAPIGP"
     CDS             7987..9261
                     /locus_tag="ctg143_13"
                     /transl_table=11
                     /translation="MKKHIMLFVILGAFFLCSCSSESQSNLPDNSRNESVQLNSNSLKM
                     ITSSWGAQEWCGTKDGFYYLNRADQNTYNISYIDYVSCVMTPLCSSPNCLHKDDTCSAY
                     FHVPNCGAAVFTDGDYLYIMTFSDGTAERNNEFPRLYRIDKDGSNRKLLLELSQGETFS
                     RYVAADETALYVNIVGSELNQQGISDVCIVQKVDINDGTAETILNLSTNAQLCGAHGDS
                     LVFQSVDIPGELGDFDLKNIKNRLYEISLSTKQQKDILTWTNGESSCIIEGETIFSLDY
                     SDSTINKRTIHNGETKNFVCQIPDDVVYDKCIFNYLDSQVLIFDLIEYGNPQTRRFAIS
                     LPNSQLHEITLGFLNSEVSYPYVVFSSTIDGLLVQCGTQQFEEEGIFSNGEMDTFTYTE
                     PLFGIIKTSDYLNNENKIQEINRID"
     CDS             9358..10110
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 177; E-value:
                     8.2e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg143_14"
                     /transl_table=11
                     /translation="MENAICNLELQVLTKIYSAKKATKKALAGVSFTLGPGLYGLLGPN
                     GAGKSTMMNIITGNLDATSGKVLWNGKNVLRMGREFRRVLGYMPQQQNLYDSFTGRRFL
                     LYIAALKEIPRSDAALQVQRVAELVHLSSELEKRLAAYSGGMKQRLLAAAALLGEPQIL
                     IMDEPTAGLDPKERVRLRQVLAQLAHDCIIIVATHVVSDVEHVASEILLLKEGQLVDQA
                     SPAALIEKYAPGGTLEDVYLAIFGEDEA"
     CDS             10107..12461
                     /locus_tag="ctg143_15"
                     /transl_table=11
                     /translation="MIRLLSAELRKVWHSRFFLLAFSVLLGANLFLLWFGTGHTPGNVP
                     SSAYRKLEQQISGMSMEDMDDFLHEELARTEGLSHIYNILRTEAYNNGQKDERLRETYA
                     DDFEQYYDIYEAGGFLKYGETLTQEYRFLNTIVLEFEQVNGYEEFLTSIEQKARQLSSI
                     SIFAESKSGYDMENIRVTDEAFRDMRGTSIQYYPQKGIMTALDFELTDVVTVFAMLLIA
                     TVLVRAERDNGLLALVRSTPAGRLHTAGAKLLALGASLAVVLACLYGVNLLYCGGLYGL
                     GPLNRSIQSVPQLMRSTWKLTVGQYLFCFFLTKWLAAFICGIWVMLAMLFARRLFTGAL
                     GALALIVFNLFIRSVIPATSRLNVIKYANLISLLRTNELLGGYRNLYWFDHPIPLLLVE
                     CVAAVLFGILFALAFCFIFSRHYFTAAGRRTGKRLFRRKIPAFTTPMRQETYKLLVMQG
                     TALLLLLFAGFQVYTAVTTESYIDADEIYYQYYMKHVEGPLTQESVDWLSQQQEEFRPI
                     YQLNAALMSKKVTSQEYQAMMQGYSSLQQKMNVFQRVIYKAQMLKEKPRMEMVYESGWL
                     KLFDQYDTQDLPDTLWASILCAVCFSGLFAMERQTGMIKVIGTTPLGRRATVRYKLLLS
                     FTVCGLITVLSLLPRFWVSIRDYGLGTWMAPVYSISEYYNAPEIPLFLMAAIQTFFRLA
                     AVSCMACVTLALSQRIGNTFGAMFASLLIFSLPPLLSVSGLTNAKWLSTYPLFHICALF
                     GASTQAVGIMLLLIVLAVCYLCTEYLFTHFK"
     CDS             12475..13773
                     /locus_tag="ctg143_16"
                     /transl_table=11
                     /translation="MRFCKYWAIGAIVITLLSACSDFRQGNSPSSTSKDFTLHAVSGSE
                     HLTNRNIELITSVYGISSQASTETGLYEIVPSGTKGSNIIYTDFDSKTRTYLCNRPECL
                     HKDENCPSWIASDSCLIFTGGTGHNIFILQLETYNSPYTGIWKAEPNGNNRNLLFQFQP
                     NQNIVNGIAADEEYLYITVQEVDSITYQPKKLMYQIDIQTGEAAELFSFNANDWLFGAY
                     EDNLIILSYDSAEKEFAYYRYCVTNGETEEFFRYSATDDEKAPVTALNGNILYLVQPIG
                     NTKAEVSCINLKNNQKLVLCSEIPFFSSETTTILDFVDNKMILQVSDTRQQDSKLAKHY
                     QYGIDLKTGEVKENLLLIENGGQAEFINICGAYKNEYCVLSGYAPQTVTLFDDNGTAYE
                     SSIYFPVYAFITKEDYWNGSEKWIAPIDLTKGG"
     CDS             13831..14364
                     /locus_tag="ctg143_17"
                     /transl_table=11
                     /translation="MKKLITLVASLLAVALLTVPVFAAENQSLAVDITKISISNEANND
                     LLNAATESSPVNGTRITTWDNTGHATQRWDYSESVPGKPQHYWLKNSANRSYAVTCYGT
                     DGQQVTLQSFTRNMTTQPVKFINEGGSSFNIYGLANTTYILALTTTGSYNGAPVLWKGS
                     NNQNNQLWVLGAWG"
     CDS             complement(14395..14655)
                     /locus_tag="ctg143_18"
                     /transl_table=11
                     /translation="MSGWFDTIWADDLPSRAVTVYMYLRSRADREGKCFPSVRTISRDT
                     KLSMSTVRRALDDLVNTGYIQKQPRWRANGAKSSNQYVFRI"
     CDS             complement(14652..15851)
                     /locus_tag="ctg143_19"
                     /transl_table=11
                     /translation="MAHPDDLASRARAEKYAKIIAKTVVTSSSGTEHGQNSYFYDAAEG
                     LITSVILLVAEFCPPETRHIVSVFKLIQDLLSPSGQKGKNQLQMLLSLLPPEHKARWFA
                     GAALTAGEQAMASVLSTAMASLNAFLDSELEQMLCFSTKIDAEKFCREKSAVFVVLPEE
                     DSSKYFMVSLLVQQMYREILVVADGQGGALKNRVMFFLDELGSLPKIESLELMFSAARS
                     RRLSIVGIIQSYGQLERNYGKEGCSIILDNAQDTIAGGFSPAGDTAEQVSRQLGEQTVM
                     TGSVSRGKSDPSRSLQMMGRRLMTPDELKSMPKGQFIVMKTGRRPMLSKLRLFLDWGIT
                     FTEPYALEQHAQREVKYAGSKELRRKILKEYGIPPGQQIVPGQERFPERQKLGLMQENV
                     "
     CDS             16398..16538
                     /locus_tag="ctg143_20"
                     /transl_table=11
                     /translation="MSTKERKHPAPPRYDEAFKAGAVRMVTEQGRPSREVAAELGICID
                     TL"
ORIGIN
        1 atttgcatcc ccggcaaggt gaatcttggt attgagcccc cttttgtacg gctcatgtcc
       61 tgattaccgc ccgggctcct gccgcatgtg gatgcacctt acagtgactg gcatcaatca
      121 tcagccattc aaaatcaggc tcatcaacca gaagttcaag cagtttttac cagattccct
      181 tgtcaagaca tcttcagaac cgctgataca cggtacccca tttcccgtag aactgaagta
      241 aatcccgcca aggtgctcct gtgcgtaaaa tacaaaacac gcaatttata aatctcaggt
      301 tatcctgtgc tattccaccc cactgccctc gttgtcctgg cagatgcggc tccagaaggc
      361 tccatacctc atcgctgatg tcgtggcgtt gttgttcatt gctcatggga acacctcttt
      421 cggatctctt gctcccatta taccatatcg ctcgtgtaaa cactatttag ctatgcaagg
      481 atttagtgga tgaaattttg ttgtacggtg cccatggtat aatagcctca agtccgccgc
      541 tactccagct acgtgtatgt gctgcatacg cttctgtgct aacgcaccgg actttgagaa
      601 cattgaacct cgcaaaaccg cagcgaatgc ggttttgttg tagccacctg caacggcgtc
      661 atggtataat ggatgatgtc atggttctta cattattata tataggagta ttctgtcccg
      721 tgaaagagaa tattgagatc caggccacca gctttgagcg gattcgtcca taccgtatga
      781 acgaagcaag cgaaaatggc gaggtttccg ccgccatcga atctatgggt aagcacggct
      841 cgatcaacag ctatttttat gtaaagctgt ccgcgcagct tcttgcacaa ctcccggcat
      901 ttaacactat gaagtttttg ctttcggatg gcggctcctg gaatctcatt ttttacactg
      961 gcactgcaaa tacacgtatc ttttcccagc agaagaaatg gaaaagctat gcacagctca
     1021 tggcatcatc atccatcatt gacatttaac tgggcgggcg aattaattgc cgcccgcccg
     1081 gttatcttca ctgcgtgcgc ccacaacgat gcatgcgtat gccagcagtg caaaaacaat
     1141 tccaacaaca attactgctc tccacatatt cacccctccc tcttcaatag gtccatctcc
     1201 agaagcagaa cagatttgct tctgaagatg gcttttattt tacagccaca tttgacacta
     1261 ctcccctgac tgtccgggca tcctatactg taggtactgg ctggtaccat catgggaatc
     1321 tcacccccgg caggatctct gccggccgcc ccctttgctt gcggctaagg ctggacggaa
     1381 gtatcattgt cctctttcca tgtcattgcg ctgcaccccg ccacagggtg ctttcagcgg
     1441 actgtattcg ctcgatacca tattctgcgg tttcagtggt tatcaacggc caccgtggtt
     1501 gtcttcgcgc atcccattcg cgcttgccgg cctggtttta cccctggtta cggctggaag
     1561 agaatgttca gtataggatg gatattctgt tttcaaagtg ccgagagttt ccctctcact
     1621 ccctagccct tgagaaagcc gtttttaacc acattgtttt taaaattatt caaattcagc
     1681 aaaatgcaca aaacagctga gattttttat ctcagctgtt ttgtatgtat actttttatc
     1741 cttttgatac tttggggata atcgacttat atttttgcac cgctcgattt ttatgattca
     1801 aaactgtttg gttatctaaa gacagtattt gcgcaatatc acttgttgca tatccctcgg
     1861 tatatagctc cacaacccga tactgctgct cggtcagact ccttaacctg gaaaggcggt
     1921 cggagcgttc aacctgatcg ataagctcgc caatatcatc ttccaaatca ggtgaatgca
     1981 tcgaatgact ttcttgaaaa agcgtatcca cccctttggg tggcctgtcc tctctttcac
     2041 aggctggcac tacatcggtc cttctgtaaa aacgtcgctc accattgaat tccagccgat
     2101 atgctctcgc tgcttccctg atttgctttc tctgcatccc tgccttcctc atttcgagtt
     2161 tggctgcttt ccattctctt ttatattccc tctctgccat ggcatgatta tacttcattt
     2221 ttactcctcc atctgatgtg aacttgtttt gggacaaggt cacacggagg agctcgtatc
     2281 catgtagatg atcgcgttgt aaatgataca gcttgtctgc ttgatgtatc tgctacgaaa
     2341 agatactctc tctcatagca ccaaatactt caccgcactc ctacattttc tttgcggtga
     2401 atatgcttga acattagcca atgctatcta accttcatta ccgcataccg aagatacgga
     2461 taaaacactg tatagttacg accctgtgct ttaacgcgcc aataatacaa ccatttgaaa
     2521 tagttaaatt ctcataattt tataatttac agcaataata catcttatag gtatattcat
     2581 attcttaaag tttcttactc aatattttat catctgatag gctttacttg aggtgattcc
     2641 catgaacgat aagctttatc gagatattgg aaagcgaata aagttggccc gacgcgcttg
     2701 ttctataact caagaaagac ttgccgagat ggtcggtgtt acaaaccaac atatcagtaa
     2761 tattgaagtc ggtaacaaag ctccttccta tgaattgctt tacgcaattg ctgaaaagcc
     2821 aaactgttct gcttatagcc ttcttcctgc agaatcttct aatagcggaa aatacttttc
     2881 agaagaaata atgcatttgc tgcaatccac tcccttcctg ctaccattca cataaagtat
     2941 tggccgtcgg gctattatgt agagtctacc tatcaagata attcccgttt ccacatggca
     3001 gcagtcaata aggacggttt atacagtaca gtagaaattc tattaatgga tgaacctcaa
     3061 acggtattac ttgataacga atattccgat tattatcgaa tatcttttgg ctcgaatgat
     3121 gccttatgga cctgtcacga atccggaaat aacattctca cttgggctga ccaaaatgtt
     3181 ctttatcaag tgaccacggc agcatcgctt aatgaggcaa tatatattgc cgaaaatatc
     3241 gaaatgggat gaaatcttct aacggttgtt ctctgcaatg ccctaaactt cagaaaacaa
     3301 tataattttt tctgtgaagc tgtaaccttt ttattgtatt tacgtatcca atatgtcttc
     3361 ctttattttt cttggaggtt atacaatgaa aaagtttatt tgtattgtgc ttaccgtcgt
     3421 cctcgcacta tcttgcatga gcgcttttgc cgctgagccg ctttcttctc aggaaggtgg
     3481 aacaaccgct caagagagca ttactccatt ttgggtcaac accctttcta tcatcccttc
     3541 catttctggc agcgccggaa catattcctg ctcaatcaat ggtgtttccg ggacaaccaa
     3601 gatttctgct actttggtac tatacgagaa aggttggcta ggcggctata cagaggtagc
     3661 gcgcaccagc cacaccacat attccgcttc attcttcaag tctgactcct acagtttcag
     3721 ctccgggaaa acttataagt tagaagtcag cggaactgtc acgcgaaatg gctatgcaga
     3781 gcctgtttct gcaactattg aacagaaaat ataattattc ccgcatttaa atctttcgag
     3841 gaagacagca gcggcattgg taaatatacc aatgccgctg ttttttactt cacattgttc
     3901 ttcgtccatg ttacaatcat tagaaacata tctatatctt atagcttcat tttttgcttg
     3961 attgaatacg ccgtctgaaa cgattcactt cggccgcccg gatggtgcat gcagaccggc
     4021 aaaatggtgc atcgccaccg tgatcatggt gcaatgtcaa cgcagccgtt aaaatgaatt
     4081 tagcatcgca agatgcgaat tcattttagg aggtcatacc agggtcaatc acaaagagat
     4141 ccttgatgtg tgagtgaccg cgaaacgctt ctatgcgggg aacactttga aaagcgttcc
     4201 ccccgctccc cctcgaaacc cgctccattc ctgcagaatg gttgcaccgt cctggcggaa
     4261 acaatacaca attcctgcgg cagagatgca ccatcatctg cggtcaagct gcactttttg
     4321 gccggcatac gcacttgatg taactattct atttttatca cgtatacaaa gtattctatg
     4381 gtgaatcgca attttgctaa attgcgagag aggagacttc gtaatgtatc aaattgctat
     4441 ttgtgatgac gaaaaaattt ttactgataa gttggctcat atgataaaac agtattccaa
     4501 tgctcatcac catgtcattg atctacacct ttttcaacag gcggccgact tcatacaaag
     4561 ttctctggag tcttacgata tcgtttttct tgatgtccgc tttggtgaaa ttagcgggat
     4621 tgaggttgcc aaagccctga gagcaaaaaa cgagaatgca attttgattt ttgtatccgc
     4681 tttcatagaa tatgctatca tgggttattc tgtacatgca tcggcatatc ttctcaaaag
     4741 tgacttggat ggaacttttg aaagttgcat ggatgagatc ttcccacaaa ttggctctaa
     4801 ggagatttca gtccgtgtgc catatgaaca tgtaaatgtt gacatccctt gtaaatctat
     4861 catctacatg gaaagctata aacgtcaaat tcaaatacat acgtcccttc cacgctatcc
     4921 ttccattctt tactacgcga agttatccga catgatagag actcttgctc cccatggatt
     4981 tcttcgaata cacaaaagct atttaatcaa tctttctcgc tgtcgaagga tccaaaaccg
     5041 actggcctac atggacaaca gtactgaact gccatgcagc agacaaaact atactgatat
     5101 cgtacaaaaa tttcttcagt ggaaggagcg ggaaatataa tggaacatct aatggagata
     5161 atgactactg gcacagaaac attctgtatt gtacttttac tcaatacatt tttcgaacga
     5221 aagtatacat catacagatt tttctttccg ctctcagctg cctttctctt ctacctttgg
     5281 ctgcccttaa acacgatact cgccacctca ttcgtcacaa aactttttat atccatcctc
     5341 atctggcttg tcttttctca aatattttat actggagcac ttccttttca tctctttctc
     5401 ttatgttcct tttttatcat actttccgga cttgattact ttacgctcct ggggatttca
     5461 tatatctttt ctttctcgtt ttccgatgct ctttccaatt ccgcacttta catcctcggt
     5521 gctttcgtct ctcgtactct gctacttcta ttctccatta ttatctaccg acttttcaaa
     5581 gctaaaacat ctatgattct gagttcgagc acttggattg cgctcttact gtttcctgta
     5641 ttttcaatcc tcttatttgg cgtaaccatt gaaattgcaa tggcacaaaa taaaatcagt
     5701 ttcaacctaa tcctcagcgg cataggttta ctgcttttta atatctcact atttctttta
     5761 cttggcaagc tggaatacag taccaaccta cagcaaaaaa atattgctct ccaacatgaa
     5821 attgatcaga acatgaagtc cacaaatgcg ctccaagcca tctttaatga gcaacgtgca
     5881 ctgacacacg atttcaataa ccacattaca acactatata tgcttcttaa agcggagcat
     5941 tacgaaaaag ctacagaata tgtaaaagtg ttgtcccaga acctaccgga aaacactcgt
     6001 gttgtcagca caaaccaccc cattctcgat accattctca atcagaaata tacacaggcc
     6061 aaacttcaaa acacatcaat gcgcttcact gtaaacgatt tatcttcttt cccaatgaaa
     6121 gacgaagatg ttgtcacact cttagggaat cttcttgaca atgcactcga agcctgtcga
     6181 aaacttcccg attcatcata tatcaatgta aaaatactaa aaaaagaggg ggactttttg
     6241 ctctctgtcg agaactcatc tttgccagta aaaatttccg aaaataatta cgtaccaacc
     6301 gataaagctg agccacgttt acatggtttc ggtcttcaaa atattgccca tatcatgcaa
     6361 aagtatgggt atgaatatac acttttttac cacgacgcac gatttcattt tgtctcaatt
     6421 ctgtcataaa agtgcagttg ggaacatttt ttgacagttg ggaacaaatc cattgtgaaa
     6481 gaattgtgaa aatgctattt taagcttaaa ggaggaggat gttattgctc ctgtcctact
     6541 gcgagaggct cacagatttt ttcatcagcc aatgtggcct tccggaaaca agaaggtctt
     6601 ggtacattta cgcattacaa actcgcattt ctatgtttct ttccactgcc ggtatgatgt
     6661 tgcttggctg ccttgttgcc acgccatacc aagtgatctg ttttcttgta ggaattttat
     6721 ctttgcgcag acgtctcggt ggctatcacg cgaagacgcc gctgcgatgc ttattcttgt
     6781 cgattggtgt atccattctc tgtttgagca ttgtaaacag ccttgttcag tatagtcttt
     6841 caattcttat ttggatttta ttcatcagtc tctcttttgc tgttttcaat tcatctcctt
     6901 atagccatcc aaactgcccg cttactcctg atgaacttgc tgtttcctgg ataaaagcga
     6961 agcatattct tatatggaat ctgcttttga ttttgttgct tcaaatcttt tttgcacatt
     7021 caaactgttc gctttattgt gaaatgggaa tcatagcggc cgctatttcc ttttttgtat
     7081 cgaaattcaa ggaggtaaaa tcatcatgaa caaaatcgca acctttcttt ctgaaaaact
     7141 ggctggcaaa ctggatgacc ttgctcgtcg cgatatgcgc gagtggccac ctacgagcgt
     7201 ccccatctat taccagccgc agcgccctca gcggaaagtt gataatacgg acaaataaag
     7261 tctttcactc actcttattg gatacagtat cgacgcgcga gatactgttc cataaggaaa
     7321 aaatagaaca aaaaggagaa gtaactcatg aagaagaaac tgattgttat tgtaacttgt
     7381 cttgtcttag cagttgctat ggcggttccc gtatttgcaa gatacgaaac atacgatata
     7441 gtaaggaatg atattgatca cataggttac caaatgtgtc ttagtctata ttctacaaga
     7501 ggcgcgtata ataattgccg tctttctacg tggaattatg agggtagttc tgaccaactt
     7561 tgggaagcaa aatataattc aaatactggg gcatatacta tgtgtgtcca gaccgaccct
     7621 aattacgccc ttaatgcgta tcgcgtactt aaaaacgatt gggatggaaa ttattaccaa
     7681 gccgatgtgt atccatatta tcaaaatcca gatgctgcag tgactttcat tagaaatttg
     7741 tcttattctt atatcaaaaa tatcacaacc gggtataact tgacagttag cggtcgaaaa
     7801 acacctgctc agccaactga tgctgattcc acaagttatt atattgattg gtacgaaaaa
     7861 agttttccgg ttgcttcaga atggagagcg gcacctattg gtccttgaca aaaacaccaa
     7921 gtttcagctg cgtcactatg cgttagcata gtgacgcttt cgagtattca gaggtgaatt
     7981 atattaatga aaaaacatat aatgctattt gtaatattgg gtgcattttt tctgtgttca
     8041 tgtagctcag aatcacaatc gaatctgccc gataatagta gaaatgaatc tgtacaatta
     8101 aacagcaata gcctcaagat gattacatcg agttggggcg cgcaagagtg gtgtggaaca
     8161 aaagatgggt tttattattt gaacagagca gaccaaaaca catacaatat ttcatatata
     8221 gattatgtta gctgcgtaat gacaccactt tgttcttcac caaactgttt gcataaagat
     8281 gacacatgtt ccgcttattt tcatgttcct aactgtggtg cagctgtttt cacagatggg
     8341 gattatctct atattatgac attttccgat ggcactgctg agcgaaacaa cgaatttcca
     8401 cgtctatata ggatcgataa agatggtagc aatcgcaaac ttttactgga actatcacag
     8461 ggagaaacct tttcaagata tgtcgccgca gatgaaacag cgttatatgt taatattgtt
     8521 ggatcagaat taaatcaaca gggaatctct gatgtttgca ttgttcagaa agtggatatt
     8581 aatgatggca ctgctgaaac aattttaaat ttatcaacaa atgctcaact ctgcggcgca
     8641 catggtgatt ctcttgtgtt tcaaagtgtc gatattcctg gtgagcttgg ggattttgat
     8701 ttaaagaata ttaaaaatcg actttatgaa atttcacttt ctactaaaca acagaaagat
     8761 attttgactt ggacaaatgg agagtccagc tgtattattg agggagagac gatcttctca
     8821 ttggattatt cagattcaac catcaataag cgaaccatcc ataatggtga aacgaaaaat
     8881 tttgtatgtc aaataccgga tgatgttgtg tatgataaat gtatatttaa ttatttggat
     8941 tctcaagttc taatttttga tttgattgag tatggtaatc cacaaacaag aagatttgcg
     9001 atttcactac ccaatagtca acttcatgaa ataacgttag gctttttaaa cagtgaggtt
     9061 tcatatccat atgttgtttt ttcaagtaca atagatggat tgttggttca atgcggtact
     9121 caacaatttg aggaagaagg cattttttca aatggagaaa tggatacttt tacatataca
     9181 gagccgctat ttggaattat aaaaacatcc gattatctaa acaatgaaaa taagatacaa
     9241 gagataaata gaattgactg attgaggtgg tgcatgatat aagatgtatt gccgacgtta
     9301 ttttaataaa tacctttctg ctgtctaaat agggagagta caactggagg cgtacctatg
     9361 gagaatgcta tatgcaattt ggaattgcag gttctcacca aaatatacag cgctaaaaaa
     9421 gcaactaaaa aggccctggc cggagtgagt ttcactctcg gcccgggcct ttacggcctt
     9481 ttggggccca atggcgcagg caaaagcacc atgatgaata tcatcaccgg gaatctggac
     9541 gctaccagcg gaaaggtact gtggaacggt aaaaatgtcc tgcgcatggg gcgggaattt
     9601 cggcgcgtcc ttggatatat gccgcagcag cagaatctgt atgacagttt tacaggccgc
     9661 cgtttcctgc tgtacatagc agcactcaaa gaaattcccc ggagtgatgc agcgttacaa
     9721 gtacaacgtg tcgcagagct ggtacacctt tccagtgaat tggaaaaacg tctggcagca
     9781 tattccggcg gcatgaaaca gcgtctgctt gctgccgccg cattgttggg tgagccgcag
     9841 atcctcatca tggatgagcc taccgccgga ttggacccga aagaacgtgt acgcctgcgt
     9901 caggtattgg cccaactcgc ccatgactgc atcattattg ttgccacaca cgtagtcagc
     9961 gatgtggagc acgttgccag tgaaatcctg ctgctcaagg aaggacaact tgtggaccag
    10021 gcgtctcctg ccgcgcttat tgaaaaatac gcaccgggcg gcacactgga agatgtctac
    10081 ctcgccattt tcggggagga cgaagcatga tacgcctgct ttccgctgag ctgcgcaagg
    10141 tgtggcacag ccgttttttt cttctggcgt tttctgtgct gctcggtgcc aacctgtttt
    10201 tgctgtggtt cggcacgggc catactccgg gcaatgttcc ctcctctgct tatcgaaagt
    10261 tggaacagca gatttccggc atgagcatgg aggatatgga tgactttctg catgaagagc
    10321 tggcccgcac agagggatta agccatatct ataacatcct gcgcacagaa gcatacaaca
    10381 acggtcaaaa agacgaacgt ctccgcgaaa cctacgccga tgattttgaa cagtattatg
    10441 atatttatga agcaggcggg ttcctgaagt acggggaaac gctgacacag gaataccgtt
    10501 ttctgaatac aatcgttctg gaatttgagc aggtaaacgg atacgaagaa tttctgacat
    10561 ccatcgaaca gaaagcccgg cagctttcct cgatctctat tttcgcggag agcaaaagcg
    10621 gatacgacat ggaaaacatc cgtgtcacag atgaagcgtt cagggatatg cgcggtacgt
    10681 ccattcagta ttatccgcaa aaaggcatca tgaccgcact ggattttgaa cttacggatg
    10741 tcgtaaccgt atttgcgatg ctgctcattg ccacggtgct tgtccgggcc gagcgggaca
    10801 acggtctgct cgcgctggtg cgttctactc cggcgggcag gctgcatact gctggcgcaa
    10861 agctgctggc gttgggcgca agcctcgcag ttgttctggc ttgcctgtat ggcgtcaacc
    10921 ttctgtactg cggcgggctc tatggtctgg ggccattgaa ccgctccatt caaagtgtgc
    10981 cgcagctgat gcgcagcaca tggaaactga cggtcggcca atatctgttc tgtttttttc
    11041 tcacgaaatg gctggcggca ttcatctgcg gtatatgggt aatgctggcg atgctgtttg
    11101 ccagaaggct tttcacgggc gcattggggg ctttggctct tattgtattc aacctgttca
    11161 tccgatctgt tatccctgcc accagcagat tgaatgtgat taaatacgcc aatcttataa
    11221 gtttactgcg caccaatgag ctgctgggcg gataccgcaa tctgtattgg tttgatcacc
    11281 cgattcctct gcttttggtg gagtgcgttg ccgctgtttt gttcggtata ttgtttgcgc
    11341 tggcattctg ctttattttc agccgtcact attttactgc agcgggacgt cggacaggca
    11401 aaagactttt caggcgtaaa atccccgcat tcacgacgcc aatgcgtcag gaaacctaca
    11461 agctgttggt gatgcagggc acagcattat tgcttttgtt atttgcgggg tttcaagtct
    11521 ataccgcagt gacaacggaa agctacatcg acgcggacga gatctattac caatattaca
    11581 tgaagcatgt ggaaggtccg ttgacgcagg aaagtgttga ttggctctcg cagcagcaag
    11641 aagaatttcg ccccatctac cagctcaatg ctgcgttaat gtcgaaaaag gtcacttcac
    11701 aggaatacca ggcaatgatg cagggttact ccagtttgca gcagaaaatg aatgtattcc
    11761 agcgtgttat ttacaaggct cagatgctga aagaaaaacc tcgtatggaa atggtctatg
    11821 aatccggctg gctgaagctg ttcgatcaat atgacacgca ggatctgcct gatacgcttt
    11881 gggcatctat cctatgtgca gtatgttttt ccgggttgtt cgcaatggag cggcagacgg
    11941 gaatgatcaa agtcatcggc acaacaccgc ttggacggcg tgccaccgtg cggtacaagc
    12001 tgttgctttc ttttactgta tgtggcttaa taacggtgct cagccttttg ccgcgctttt
    12061 gggtctctat ccgtgactac ggacttggca catggatggc tccggtttac agcatcagcg
    12121 aatattacaa cgcgccggaa atacctttgt ttttaatggc agcaatccag actttttttc
    12181 gattggccgc ggtgagctgt atggcctgtg tgacgctggc tctttcgcag cggattggca
    12241 acacctttgg cgcaatgttt gcgtcgctgc tcattttttc tctgccgccg ctgctcagtg
    12301 tctccggctt aacgaatgcg aagtggctta gtacataccc gttgttccac atctgtgcgc
    12361 tctttggcgc aagtacgcag gcggtcggaa ttatgctttt gctgattgtt ctagccgttt
    12421 gctatctttg cacagaatac ttgttcactc atttcaaatg aagaggtact gaatatgcgc
    12481 ttttgcaaat attgggcaat tggagctatt gtcattactt tgttgtctgc ctgtagtgat
    12541 tttaggcaag gaaactcccc ctcttccact tcaaaggact ttacgttaca tgcggtatcg
    12601 ggtagcgaac atttgacaaa cagaaacata gagttgatca ctagtgtcta tggcatttcc
    12661 agccaagctt caacagaaac gggactttat gaaattgtac catcagggac aaaggggtca
    12721 aatattatat acacagattt tgattctaaa acaagaacat atctatgcaa ccgacctgaa
    12781 tgtctgcaca aagatgaaaa ctgcccctcg tggattgcct ctgactcctg tctgatattc
    12841 acaggtggca ctggacacaa catcttcatt ttgcagttag aaacctacaa ttctccctat
    12901 acgggcatat ggaaagccga accgaatggc aataacagaa atctgttatt ccagtttcaa
    12961 cccaaccaaa atatcgttaa tggaattgcc gctgacgaag aatatctcta cattacagtg
    13021 caggaagttg attctattac atatcagcct aaaaaactta tgtaccaaat cgatattcaa
    13081 acaggcgaag cagcagagct attttcgttc aacgcaaacg attggttgtt tggcgcatat
    13141 gaggataatt taattatcct gtcctatgat tcggcagaaa aagaatttgc atattaccgc
    13201 tattgtgtta caaacgggga gacagaagaa tttttcagat attctgctac tgacgatgaa
    13261 aaagcgcctg ttactgcgct caacggaaat atactatacc ttgttcaacc aatcggaaat
    13321 actaaagcag aagtaagttg tatcaatctt aagaacaatc aaaaactggt actatgctct
    13381 gaaattccgt ttttttcatc tgagacaacg actatccttg actttgtaga caataagatg
    13441 atccttcaag tgtctgatac ccgacaacaa gattccaaat tggctaagca ctaccagtat
    13501 ggcatcgatt taaaaaccgg agaggtaaaa gaaaatctat tacttattga aaatggagga
    13561 caggctgaat tcatcaatat atgcggtgca tataaaaatg aatactgtgt tttatcaggc
    13621 tatgcccctc aaacagtaac cttatttgat gataacggta ccgcttatga atcgtccata
    13681 tactttccag tatacgcatt tatcacaaag gaagattatt ggaacggttc agaaaaatgg
    13741 atcgctccaa ttgatttgac gaaaggaggg tagcgtttca attctagccc ataatagcaa
    13801 aaattcgtac aaaccaaagg agagattacg atgaaaaaac ttattacttt agttgccagt
    13861 cttttggccg tcgctttatt gacagttcca gtcttcgcag cggaaaatca atctttagct
    13921 gtagatataa ccaaaatatc tatctccaat gaagccaaca acgaccttct aaatgccgcg
    13981 actgaaagtt ctccggtgaa tggcacccgt atcaccactt gggataatac agggcacgca
    14041 acacaacggt gggactactc tgaaagtgtt cctggaaaac ctcaacatta ttggttaaaa
    14101 aattccgcca atagatctta cgctgttaca tgttacggta ccgatggaca acaagttacc
    14161 ctacagtcat tcacacgcaa catgacgaca cagcccgtta aattcattaa tgaaggcggt
    14221 tcttctttta atatttacgg tttggcaaat accacatata ttttagctct gacaactacc
    14281 ggttcctata atggtgcacc tgtcttatgg aaaggttcaa acaatcaaaa taatcaattg
    14341 tgggttttag gcgcatgggg ataaaccaat aaagctactg atcttgaacc cagattaaat
    14401 tctaaaaaca tattggttgc tgctcttggc cccgttggct ctccaacggg gctgcttttg
    14461 tatgtaaccg gtattgacca gatcatccag cgcccggcgt accgtgctca tggacagctt
    14521 tgtatccctg ctgatcgtgc ggacggaggg gaagcatttc ccctccctgt ccgcacggct
    14581 gcgcagatac atgtataccg tcacagcccg gctgggcagg tcatccgccc aaatggtatc
    14641 aaaccagccg ctcacacgtt ctcctgcatc agccccagct tctgccgctc cgggaaccgt
    14701 tcctgccccg gtacaatctg ctgccccggc gggataccgt actctttcag tatcttcctt
    14761 ctcaactctt tgctccccgc atatttcact tcccgctgcg catgctgctc caatgcatac
    14821 ggctctgtaa atgtgatgcc ccaatccagg aacagccgca gtttggacag cattggacgc
    14881 cgccctgtct tcatcacgat aaactgccct ttgggcattg atttcagttc atccggcgtc
    14941 atcagccgcc gccccatcat ctgcaggctg cgggacgggt cacttttccc cctgctcaca
    15001 ctccccgtca tcacagtctg ctctcccagc tggcgcgaca cctgttccgc cgtatcgccc
    15061 gcggggctga agcctcccgc gatggtatcc tgcgcattgt ccagaataat ggaacatccc
    15121 tctttcccgt agttccgctc cagctgtccg taggactgga tgatccccac gatgctcagc
    15181 cgcctcgaac gcgccgcgct gaacatcagc tccagcgact ctatcttcgg aagcgatccc
    15241 agctcatcca gaaaaaacat caccctgttt ttcaacgcgc ctccctgtcc gtccgccacc
    15301 acaaggatct cccggtacat ctgctgcacc agcaggctca ccatgaaata tttgctgctg
    15361 tcttcctccg gcaacaccac gaacacagcg gacttttcac ggcagaattt ctccgcgtca
    15421 atcttggttg aaaagcacag catctgctca agctctgaat ccagaaacgc gttcaaactc
    15481 gccattgccg tggaaagaac ggacgccatc gcctgctctc ccgcggtgag cgccgccccc
    15541 gcaaaccacc tcgccttgtg ttcgggcggc aggaggctca aaagcatctg cagctgattc
    15601 tttcctttct ggccggacgg agacaggaga tcctgtatca gcttgaacac tgaaacgatg
    15661 tgccttgtct ccggcggaca gaattccgcg accagcagga tcacggaggt gatgaggcct
    15721 tcggccgcgt catagaaata ggagttctgt ccatgctctg tcccgctgct ggatgtgacg
    15781 accgttttcg caatgatctt cgcatacttc tccgcccgcg ccctgcttgc cagatcgtcc
    15841 gggtgcgcca tatatgcgtc catgtacttg ttgacaagat ccaacaggtt gttgccgtca
    15901 ctgcacgccg gattgcgcaa gtctaaaacc gaaacatcat acccatatat gtctttggcg
    15961 atgcccgcgt aatttcgcgc gaggttttgc gataggtaat cctttgaact tatctccaga
    16021 ttttcccccg cttagcaccg tgcgcgacag tttcccatca cacggcgccc catcaatgtt
    16081 tacctattta caattttaca attgccagcc aattccctca gtttgttcag tcggaccatg
    16141 ttcagcttgc agaagttcag cttgttaaga tactttctta cggtttcatc atccgtggcg
    16201 tgaatcaact gatgtacatc cggcgagaca agaataagat tttcataatt atccccgccg
    16261 cctgaccgcc ttggcgtaat atggtgaacg acaatgttcc ccaatgtcag cggctccttg
    16321 ctgattgcgc actttgcccc catacccgat ttgccggaca gaaaaacaat ctgtataatg
    16381 gaaaggggta atgaaaaatg tcaactaaag aacgaaaaca cccagcgccg ccgcgttacg
    16441 atgaggcctt caaggcgggg gcagtgcgga tggtcaccga gcaggggcgg cccagccggg
    16501 aggtggccgc ggaactcggc atctgcatcg acacgctg
//
