LOCUS       gnlProkkaCJENKGDL_145   5912 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJENKGDL_145.
ACCESSION   gnlProkkaCJENKGDL_145
VERSION     gnlProkkaCJENKGDL_145
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:38:37
            Original ID  :: gnl|Prokka|CJENKGDL_145
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5912
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5912
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[3246:5910]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3247..5910
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..5912
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5912
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS             3..302
                     /NRPS_PKS="Domain: Thioesterase (2-91). E-value: 3.3e-11.
                     Score: 35.9. Matches aSDomain:
                     nrpspksdomains_ctg145_1_Thioesterase.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 91.9; E-value: 5.4e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_1"
                     /transl_table=11
                     /translation="MILENQELLDFFLPMLRADFTMDETYYDKAGVVLHTPISAFGGEK
                     DGEADESAICEWGKYTDNDFDYRIFPGGHFYLRDYEDEVISEVERRLQGMKNGG"
     aSDomain        9..275
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_1_Thioesterase.1"
                     /evalue="3.30E-11"
                     /label="ctg145_1_Thioesterase.1"
                     /locus_tag="ctg145_1"
                     /protein_end="91"
                     /protein_start="2"
                     /score="35.9"
                     /tool="antismash"
                     /translation="LENQELLDFFLPMLRADFTMDETYYDKAGVVLHTPISAFGGEKDG
                     EADESAICEWGKYTDNDFDYRIFPGGHFYLRDYEDEVISEVERR"
     CDS             292..990
                     /NRPS_PKS="Domain: ACPS (126-185). E-value: 6.4e-12. Score:
                     37.3. Matches aSDomain: nrpspksdomains_ctg145_2_ACPS.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 158.2;
                     E-value: 3.2e-48)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_2"
                     /transl_table=11
                     /translation="MEVKRCGEKEFLSSDKLRIRENEIHIWCICWPEMTDFWKNHEYIL
                     SEQESEQAGKFRFPEDRMRYIAGKLIVRILLKRYLDVETVDFSVNELGKPYHKEIAGKQ
                     TVNFNISHSGEFILEGFAVGMDIGVDVQEMVGCPDYREIAGNFYTAEEAEDVINEGPEL
                     FFQYWAAKEAYVKAIGIGLGRGMDFFSVRNGEITEKGRKGQGWHLYPVKIEGYAAYVAA
                     HKKGDKSNEL"
     aSDomain        670..846
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_2_ACPS.1"
                     /evalue="6.40E-12"
                     /label="ctg145_2_ACPS.1"
                     /locus_tag="ctg145_2"
                     /protein_end="185"
                     /protein_start="126"
                     /score="37.3"
                     /tool="antismash"
                     /translation="IGVDVQEMVGCPDYREIAGNFYTAEEAEDVINEGPELFFQYWAAK
                     EAYVKAIGIGLGRG"
     CDS             980..2569
                     /NRPS_PKS="Domain: AMP-binding (25-431). E-value: 4.7e-79.
                     Score: 257.7. Matches aSDomain:
                     nrpspksdomains_ctg145_3_AMP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     427.4; E-value: 1e-129)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_3"
                     /sec_met_domain="AMP-binding (E-value: 2e-87, bitscore:
                     281.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKKDMSKYEHLEGWERCGFGEQLDKWAEKYGERTAVTDSEDEI
                     SYMELKQKADCLAAAFLRKGILKGDKVLVQLPNRISFVIVFFALSKIGAVPIMMLPAHR
                     EAELEGIIELAKPAAYIVVEKYLGFSYVPMANAMKEKYSCIRHIFVDSESGDISEMIAE
                     TCGENGAFPAVDGYETAVLLLSGGTTGVPKLIPRTHTDYMYNARMSAKRCRLDSSDVYL
                     ASLPVAHNFPLCCPGLLGTLDVGGKVVLASATSPDDILDAITEEGITITALVPAMVTVC
                     MEMLEWDEDYDISSLRILQVGGAMLEDSLADKIIEEWPCKLMQVFGTAEGLLSFTSPED
                     EGSLIARCQGTPVSPADEVKIVDEEDKAVPEGVFGELLSRGPYTIDGYYMAEEANKKSF
                     TSDGFYRTGDKAMWTKDGRLRLGGRIKEQINRAGEKIMPSEIEAYLCRHSKIKEAAVVG
                     VTDETLGNRICAFLVTDDEAGIDLQEIHRFLREIGVAAYKMPDQIERVETWPLTSVGKI
                     DKKALERMAQEK"
     aSDomain        1055..2272
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_3_AMP-binding.1"
                     /evalue="4.70E-79"
                     /label="ctg145_3_AMP-binding.1"
                     /locus_tag="ctg145_3"
                     /protein_end="431"
                     /protein_start="25"
                     /score="257.7"
                     /specificity="substrate consensus: diOH-Bz"
                     /tool="antismash"
                     /translation="DKWAEKYGERTAVTDSEDEISYMELKQKADCLAAAFLRKGILKGD
                     KVLVQLPNRISFVIVFFALSKIGAVPIMMLPAHREAELEGIIELAKPAAYIVVEKYLGF
                     SYVPMANAMKEKYSCIRHIFVDSESGDISEMIAETCGENGAFPAVDGYETAVLLLSGGT
                     TGVPKLIPRTHTDYMYNARMSAKRCRLDSSDVYLASLPVAHNFPLCCPGLLGTLDVGGK
                     VVLASATSPDDILDAITEEGITITALVPAMVTVCMEMLEWDEDYDISSLRILQVGGAML
                     EDSLADKIIEEWPCKLMQVFGTAEGLLSFTSPEDEGSLIARCQGTPVSPADEVKIVDEE
                     DKAVPEGVFGELLSRGPYTIDGYYMAEEANKKSFTSDGFYRTGDKAMWTKDGRLRLGGR
                     IKEQINR"
     CDS             2584..3210
                     /NRPS_PKS="Domain: PP-binding (5-63). E-value: 3.9e-13.
                     Score: 41.7. Matches aSDomain:
                     nrpspksdomains_ctg145_4_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg145_4"
                     /sec_met_domain="PP-binding (E-value: 3.5e-14, bitscore:
                     41.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 4.8e-18, bitscore:
                     53.6, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYIEIKEQIKQKLPVARDLGDSENLLELGLSSLTIMRLVNQWRK
                     QGVKVSFGSLMENPTLEGWWALIQRSMKKKAGKKRAQESKITPEKDMKQPFPLTDVQYA
                     YWVGRDEEQALGGIDCHAYLEFDGGNIDPERLEKAWNVLQYHHPMLRACFLEDGTQKIL
                     DKPYCEKIKVHDFSRMSSEEAEAMAVSVRERLSHRKLKIEEGEVA"
     aSDomain        2599..2772
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_4_PP-binding.1"
                     /evalue="3.90E-13"
                     /label="ctg145_4_PP-binding.1"
                     /locus_tag="ctg145_4"
                     /protein_end="63"
                     /protein_start="5"
                     /score="41.7"
                     /tool="antismash"
                     /translation="IKEQIKQKLPVARDLGDSENLLELGLSSLTIMRLVNQWRKQGVKV
                     SFGSLMENPTLEG"
     CDS_motif       2881..2910
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_4_0001"
                     /evalue="7.30E-04"
                     /label="Cy1"
                     /locus_tag="ctg145_4"
                     /protein_end="109"
                     /protein_start="99"
                     /score="12.0"
                     /tool="antismash"
                     /translation="DVQYAYWVGR"
     CDS_motif       3019..3063
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_4_0002"
                     /evalue="8.20E-08"
                     /label="Cy2"
                     /locus_tag="ctg145_4"
                     /protein_end="160"
                     /protein_start="145"
                     /score="24.5"
                     /tool="antismash"
                     /translation="HHPMLRACFLEDGTQ"
     aSDomain        3247..3756
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_5_Heterocyclization.1"
                     /evalue="3.80E-53"
                     /label="ctg145_5_Heterocyclization.1"
                     /locus_tag="ctg145_5"
                     /protein_end="170"
                     /protein_start="0"
                     /score="172.6"
                     /tool="antismash"
                     /translation="MHVDMALLVADVQSLQILLRDLAAAYRGESLPAESKGWNFASYLE
                     RQKEEDKEERNNAEGYWKKRLEHLPKGPGLPLAKRPQEVTKTVFNRRIVRIGKEEWAHL
                     QVRAKEYQTTPAMVLLTAYATVLERWSRNHRFLINIPFFNRKTEQQGLEDVIADFTTLL
                     LLEIDCE"
     aSModule        3247..5427
                     /domains="nrpspksdomains_ctg145_5_Heterocyclization.1"
                     /domains="nrpspksdomains_ctg145_5_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg145_5"
                     /tool="antismash"
                     /type="nrps"
     CDS             3247..5910
                     /NRPS_PKS="Domain: Heterocyclization (0-170). E-value:
                     3.8e-53. Score: 172.6. Matches aSDomain:
                     nrpspksdomains_ctg145_5_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (332-727). E-value: 1.4e-83.
                     Score: 272.6. Matches aSDomain:
                     nrpspksdomains_ctg145_5_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     120.8; E-value: 1.4e-36)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg145_5"
                     /sec_met_domain="Condensation (E-value: 7.2e-33, bitscore:
                     102.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-97, bitscore:
                     315.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVDMALLVADVQSLQILLRDLAAAYRGESLPAESKGWNFASYLE
                     RQKEEDKEERNNAEGYWKKRLEHLPKGPGLPLAKRPQEVTKTVFNRRIVRIGKEEWAHL
                     QVRAKEYQTTPAMVLLTAYATVLERWSRNHRFLINIPFFNRKTEQQGLEDVIADFTTLL
                     LLEIDCEGNPTFAELLDRIQKQLHEDMKYTAYSGVQVQRDLAQMYGDASAVAPVVFACN
                     LGTPLVNDTFRKELGQFSYMISQTPQVWNDFQSYEDENGVQLTWDSVDKLFPENMIPDM
                     LECFENLLHELGKKDWNQRFDVLPEKRKREIEDTARTGVPERVECLHWAVMNHAEVCPE
                     DIALIDAGSGRSVSYGELKARATAVAAGISEKDIKGVPVALTLPRGIEQIESALGILLS
                     GNSYLPVSLSQPKDRRALIHEKTGVRYVVTNRELSEKLDWPEGTEILVMEGMEEGQENV
                     RLPEVSPKDSAYIIMTSGSTGVPKGVEIAHESAWNTVQDINEKYHVTSADRALAVSAMD
                     FDLSVYDVFGILGAGGTLVLLPEQERRNADYWLEQVLKYQITVWNSVPVLLDMLLIRAE
                     SMKQKLPIRAVMLSGDWIGMDLPQRVAAWTEDCQFVAMGGATEASIWSNYQNVTLPMPK
                     NWKSIPYGKPLRYQAYRVVDEYGRDCPYWAEGELWIGGFGVAKGYRGDSALTGQKFITD
                     QYGRWYRTGDLGRIWDDETIEFLGRKDHQVKIRGHRIELGEIEHAIQEFPGVAHAVVDT
                     VSDGHGNKTLAAYIGAPIQEDSKVTTYLYGTDIFGGGWKELKDDVSNWQMQQERKTAYK
                     NFLAYADQRCVQLMLETLIELGVFVSEKEVLSQKEIFEKGSITETQKNTVARWLEILKK
                     EGILREEDGRLSRTGKE"
     CDS_motif       3271..3324
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0001"
                     /evalue="7.40E-04"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg145_5"
                     /protein_end="26"
                     /protein_start="8"
                     /score="12.3"
                     /tool="antismash"
                     /translation="VADVQSLQILLRDLAAAY"
     CDS_motif       3583..3639
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0002"
                     /evalue="5.80E-09"
                     /label="Cy4"
                     /locus_tag="ctg145_5"
                     /protein_end="131"
                     /protein_start="112"
                     /score="28.6"
                     /tool="antismash"
                     /translation="TTPAMVLLTAYATVLERWS"
     CDS_motif       3700..3750
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0003"
                     /evalue="8.20E-06"
                     /label="Cy5"
                     /locus_tag="ctg145_5"
                     /protein_end="168"
                     /protein_start="151"
                     /score="18.2"
                     /tool="antismash"
                     /translation="LEDVIADFTTLLLLEID"
     CDS_motif       3973..4023
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0004"
                     /evalue="4.40E-06"
                     /label="Cy7"
                     /locus_tag="ctg145_5"
                     /protein_end="259"
                     /protein_start="242"
                     /score="19.6"
                     /tool="antismash"
                     /translation="ISQTPQVWNDFQSYEDE"
     aSDomain        4243..5427
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg145_5_AMP-binding.1"
                     /evalue="1.40E-83"
                     /label="ctg145_5_AMP-binding.1"
                     /locus_tag="ctg145_5"
                     /protein_end="727"
                     /protein_start="332"
                     /score="272.6"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="NHAEVCPEDIALIDAGSGRSVSYGELKARATAVAAGISEKDIKGV
                     PVALTLPRGIEQIESALGILLSGNSYLPVSLSQPKDRRALIHEKTGVRYVVTNRELSEK
                     LDWPEGTEILVMEGMEEGQENVRLPEVSPKDSAYIIMTSGSTGVPKGVEIAHESAWNTV
                     QDINEKYHVTSADRALAVSAMDFDLSVYDVFGILGAGGTLVLLPEQERRNADYWLEQVL
                     KYQITVWNSVPVLLDMLLIRAESMKQKLPIRAVMLSGDWIGMDLPQRVAAWTEDCQFVA
                     MGGATEASIWSNYQNVTLPMPKNWKSIPYGKPLRYQAYRVVDEYGRDCPYWAEGELWIG
                     GFGVAKGYRGDSALTGQKFITDQYGRWYRTGDLGRIWDDETIEFLGRKDHQVKIR"
     CDS_motif       4651..4710
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0005"
                     /evalue="2.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg145_5"
                     /protein_end="488"
                     /protein_start="468"
                     /score="26.1"
                     /tool="antismash"
                     /translation="AYIIMTSGSTGVPKGVEIAH"
     CDS_motif       5230..5319
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0006"
                     /evalue="1.20E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg145_5"
                     /protein_end="691"
                     /protein_start="661"
                     /score="33.7"
                     /tool="antismash"
                     /translation="PYWAEGELWIGGFGVAKGYRGDSALTGQKF"
     CDS_motif       5392..5457
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg145_5_0007"
                     /evalue="2.30E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg145_5"
                     /protein_end="737"
                     /protein_start="715"
                     /score="41.9"
                     /tool="antismash"
                     /translation="FLGRKDHQVKIRGHRIELGEIE"
ORIGIN
        1 aagagatact agagaatcag gaattgttgg atttctttct gcctatgctg cgggcggatt
       61 ttaccatgga tgaaacgtat tatgataaag cgggagtagt gctgcataca cctatctctg
      121 catttggcgg agaaaaggac ggtgaagcgg atgagagtgc aatctgtgaa tggggaaagt
      181 atacggataa tgattttgac taccgaatat ttccgggagg gcatttttat ctgcgggatt
      241 acgaagacga agtaataagt gaggttgaga gacggcttca gggaatgaaa aatggaggtt
      301 aaacgatgcg gggagaagga atttctgtca tcagacaaac ttcgtatccg tgaaaatgag
      361 atacatatat ggtgcatctg ttggccggaa atgacagatt tctggaagaa tcatgaatat
      421 atcctgagtg agcaggagtc ggagcaagcc ggaaagttcc gctttcctga agacaggatg
      481 cgttatattg ccgggaaact tatcgtgcga attctcttga aaagatactt agatgtggaa
      541 acagttgatt tttctgtcaa tgaactgggt aagccttatc ataaagaaat cgcaggaaag
      601 cagacagtca attttaatat ttcgcattcg ggggaattca tactggaggg attcgctgtc
      661 ggaatggata tcggagtgga tgtgcaggaa atggtaggat gcccggatta cagggagata
      721 gccgggaatt tctatacggc agaagaagct gaagatgtaa taaatgaggg accggaactg
      781 tttttccagt attgggcggc gaaagaagcg tatgtaaaag cgatcggtat tggattggga
      841 agaggaatgg atttcttctc tgtcagaaac ggggaaatta cagaaaaagg caggaaaggt
      901 cagggatggc atttgtatcc ggtaaagatt gagggatatg ctgcgtatgt ggcggcgcat
      961 aagaaaggag acaaatcaaa tgagttataa gaaggatatg agcaaatacg agcatctgga
     1021 aggatgggaa cgatgcggct ttggagagca gcttgataag tgggcggaaa aatatggaga
     1081 aagaactgcg gtcacggaca gcgaagacga gatcagttat atggaattaa agcaaaaagc
     1141 agattgtctt gcggcagctt ttctgcgtaa agggatttta aagggagaca aagtgcttgt
     1201 gcagcttccg aataggattt cttttgtgat cgtgtttttt gcgctttcca agattggggc
     1261 ggtgccaatc atgatgctgc cggcccacag ggaggcggaa ctggaaggaa ttattgaact
     1321 ggcaaagccg gccgcttata ttgtggtgga gaaatatctg ggattttcat atgtgccgat
     1381 ggcaaatgcg atgaaagaga aatattcatg tatccggcat atatttgtag atagcgaatc
     1441 cggggatatc agtgaaatga ttgcggaaac gtgtggagaa aatggagcat ttccggctgt
     1501 ggatgggtat gaaacggcgg tgcttttgct gtccggcggg acgacagggg ttccgaaact
     1561 gattccgcgc acccatacgg attatatgta taatgcccgc atgtccgcga agagatgccg
     1621 tctggatagc agtgacgttt atctggcgtc tcttccggta gctcataatt tcccgttatg
     1681 ctgcccgggg cttttaggca cgctggacgt gggaggaaaa gttgtgcttg cgtctgcgac
     1741 cagcccggat gatatccttg acgcaattac agaggaaggt atcacgataa cggcattggt
     1801 tcctgctatg gttactgtgt gcatggaaat gctggaatgg gatgaagatt atgatatatc
     1861 cagcctgcgg attttgcagg tgggcggcgc aatgctggaa gattcccttg cggataagat
     1921 cattgaagaa tggccgtgta aactgatgca ggtatttggt acggcggagg ggctactgtc
     1981 ctttactagc ccggaggatg aaggttccct gatcgcaaga tgccagggaa ctccggtgtc
     2041 tcctgcggat gaagtaaaga ttgtggatga agaagataag gccgtaccgg aaggagtttt
     2101 tggggaatta ttatccagag gcccgtatac gattgatggt tattatatgg cggaggaagc
     2161 gaataaaaag agctttacgt cggacggatt ttaccggacg ggcgataaag ctatgtggac
     2221 gaaagacgga aggttacgtt tgggcgggag gatcaaagag cagattaacc gcgccggaga
     2281 aaagatcatg ccttcagaga ttgaagctta tctttgcagg cattcgaaaa tcaaagaggc
     2341 agccgttgtc ggcgttacgg atgaaaccct tggaaaccgg atatgtgcat tccttgtgac
     2401 cgatgatgaa gccgggatcg atttgcagga aatccacagg ttcctgcggg aaataggcgt
     2461 tgcggcgtat aaaatgccgg atcagataga acgggtagag acatggccgc tgaccagcgt
     2521 aggaaaaata gataagaaag cattagaacg gatggcgcag gaaaaataga aggagacaga
     2581 atcatggaat atatagagat aaaggaacag atcaaacaaa agctgccggt agccagagat
     2641 ttgggggatt ccgaaaatct gctggagctt gggctttcat ccctgacgat catgcgtctg
     2701 gtaaaccagt ggagaaaaca gggggttaag gtttcattcg gttcattgat ggaaaatcct
     2761 acccttgaag gctggtgggc gctgatccag cgcagcatga agaaaaaagc gggcaaaaaa
     2821 cgggcgcaag aatctaagat aacgccggaa aaggatatga aacagccgtt tcctttaaca
     2881 gacgtacagt atgcatattg ggttggcagg gatgaagaac aggctcttgg aggaatagac
     2941 tgtcatgcgt atttagagtt tgatggggga aatatagatc cggagcgtct ggaaaaagca
     3001 tggaatgtgc tgcagtatca tcatcccatg ctgcgtgcct gctttttgga agatgggaca
     3061 cagaaaatcc tggataagcc gtattgtgaa aaaataaagg ttcatgattt ttcacggatg
     3121 tcatctgagg aagcagaggc aatggcagta tctgtcagag aacgtttatc ccatcggaag
     3181 ctaaagatcg aggaaggcga agtggcatga atagagctta cgctttttcc tgaaaatagg
     3241 gcacgcatgc atgtggatat ggcacttttg gttgccgatg tacagagtct gcagatctta
     3301 ttgagggatt tggcggctgc ctatcgcgga gaaagtcttc cggcagaatc aaaagggtgg
     3361 aattttgctt cttatctgga acggcagaaa gaggaagata aggaagagag aaacaatgca
     3421 gaaggatact ggaaaaaacg cttggagcat ttgccgaaag ggccaggcct gccactggca
     3481 aaacggccgc aggaagtgac aaagactgta ttcaaccgca ggattgtaag gattggcaag
     3541 gaagagtggg ctcatctgca agtacgggca aaggaatacc agacaactcc ggcaatggtt
     3601 cttcttactg catatgcgac ggttttggaa cggtggagca ggaatcatcg tttccttatt
     3661 aatattccat tttttaaccg gaaaacagag cagcagggat tggaagacgt gatagcagat
     3721 ttcactacac tgttattgct ggagattgac tgcgaaggga atccgacgtt tgcagaattg
     3781 ctagacagga tccagaagca gctccatgag gatatgaagt atacggcata ttccggcgtg
     3841 caagtccaga gagaccttgc acagatgtat ggagacgcat cggcagtggc gccggttgtt
     3901 tttgcctgca atctgggaac gccgttggta aatgatacgt tccggaaaga actggggcag
     3961 ttttcctata tgatttccca aacgccgcag gtgtggaatg acttccagag ttatgaagat
     4021 gaaaatggcg tacagcttac atgggacagc gtggataagt tattcccgga gaatatgatc
     4081 ccggatatgc tggagtgttt tgagaatctt ctgcatgaat tgggaaagaa ggactggaat
     4141 cagcgatttg atgtgcttcc tgaaaaaaga aaaagagaaa ttgaagatac agcgcgtaca
     4201 ggagtgccgg agcgtgtgga atgcctgcat tgggctgtta tgaaccatgc ggaagtttgc
     4261 ccggaagata ttgcgcttat tgatgcggga agcggaagat cggtatccta tggggaatta
     4321 aaagcacggg caacagcagt ggcggcagga atttcagaaa aggatattaa gggcgtcccg
     4381 gttgcactta ccctgccgcg cgggatagaa cagatcgagt cggcattagg aattttgctt
     4441 tccggaaatt cataccttcc ggtcagctta agccagccta aagatcggag agcgttaatc
     4501 catgagaaga cgggagtccg ctatgtggtc acgaatcggg aattatccga aaaactggac
     4561 tggccggaag gtacggagat ccttgtgatg gaaggtatgg aagagggaca ggaaaatgtg
     4621 agactgccag aggtgtcgcc gaaggacagc gcctatatca tcatgacgtc aggctctaca
     4681 ggtgttccga agggtgtaga gattgcgcat gaaagcgcat ggaatacggt tcaggatatt
     4741 aatgaaaagt accatgtgac aagtgcagat cgggcgctgg ctgtatcagc tatggatttt
     4801 gacctgtcgg tatatgatgt ttttggaatt ttaggcgcag gaggaacatt ggtattgctt
     4861 ccagagcagg agagaaggaa tgcggattac tggctggaac aagtgttgaa atatcagatt
     4921 accgtttgga attcagtgcc ggtgcttctg gatatgcttt tgatacgggc ggaatccatg
     4981 aaacagaaac tgccgatcag ggcggttatg ctttccggag attggattgg gatggatctc
     5041 ccgcagaggg ttgcggcatg gacagaggat tgccagtttg tcgctatggg aggagctaca
     5101 gaggcaagta tctggtccaa ttatcagaat gttaccctgc cgatgccgaa aaactggaaa
     5161 tctattccct atggaaagcc actcagatat caggcatatc gtgttgtgga tgagtatgga
     5221 agggattgcc cttactgggc agaaggcgaa ctctggattg gtggttttgg tgtggcaaaa
     5281 ggatacaggg gagattctgc gcttacgggg cagaaattta tcacagatca gtatggaaga
     5341 tggtatcgga ccggcgatct cggaagaatc tgggatgatg agacaattga atttttggga
     5401 agaaaagacc atcaggtaaa gatccgcgga cacaggattg aattgggaga aattgaacat
     5461 gcaattcagg agtttccggg tgtggctcat gcagttgttg atacagttag tgatggtcat
     5521 ggcaataaaa cgctggctgc ttatatcgga gcgccgatac aggaagattc taaagttaca
     5581 acgtatttgt acggcacaga tatctttggc gggggctgga aagaactgaa ggatgatgtc
     5641 agcaattggc agatgcagca ggaacggaag acagcataca aaaatttcct tgcctatgca
     5701 gaccagagat gtgtacagct tatgctggag acactcatag agttaggcgt ttttgtatca
     5761 gagaaggaag ttctttcgca gaaggaaatt tttgaaaaag ggagcattac ggaaacacag
     5821 aagaatactg tggcaagatg gttggaaatt ttaaagaagg aaggaatcct gagagaagag
     5881 gacggcagac tatcgcgtac cgggaaggaa gt
//
