LOCUS       c00040_gnlPro..        13776 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJENKGDL_40.
ACCESSION   c00040_gnlPro..
VERSION     c00040_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:28:34
            Original ID  :: gnl|Prokka|CJENKGDL_40
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13776
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13776
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5901:13776]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5902..13776
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13776
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13776
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             283..999
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BMC"
                     /gene_functions="encapsulation (smcogs) SMCOG1011:Bacterial
                     Microcompartment (BMC) domain (Score: 40.1; E-value:
                     9.2e-13)"
                     /gene_kind="encapsulation"
                     /locus_tag="ctg40_1"
                     /sec_met_domain="BMC (E-value: 5.7e-14, bitscore: 41.8,
                     seeds: 429, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDIKNISTHCTRSEFVGKAVLDTIGLVISGIDDTLLKEMNIGTK
                     YHCLGLFSSRTGAAGQLTALDDAVKATNTEVLSIELPRDTKGWGGHGNYIVLGGTDVSD
                     VRHAISMALELTNKNAGEVYISESGHLEFAYSASAGQVLNKAFGVPMGEAFGFMAGSPA
                     AIGLVMADTAMKSASLSIAKYMTPDKGTSHSNEVILAVAGDASAVKTAVLNARQIGLEL
                     LIAMGSYPETPGVPYL"
     CDS             1159..1647
                     /locus_tag="ctg40_2"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGIVDMRRDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
     CDS             2001..2999
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.9; E-value: 5.4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_3"
                     /sec_met_domain="SBP_bac_1 (E-value: 1.1e-18, bitscore:
                     57.9, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGFAVVLALMPVQAFGKTVSVTNVSYDPTREMFEQYNK
                     IFEDHWKEKTGEDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPKDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPNVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             3070..3906
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.4; E-value: 5.7e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_4"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.2e-26, bitscore:
                     83.4, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLVSFYTSFVCAFAAAVINGIMGTVLAWVLVKYDFPGRRLMDGMIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSELQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             3906..4730
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60.2; E-value: 7.1e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg40_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.5e-19, bitscore:
                     60.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVVISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGMKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             4732..5790
                     /locus_tag="ctg40_6"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSQ
                     GVVERVSFRGDNLELQVRVNNSVVTARRSLEKTDIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             5902..7647
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.4; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_7"
                     /sec_met_domain="FAD_binding_2 (E-value: 5.6e-23, bitscore:
                     71.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 2.1e-08,
                     bitscore: 24.1, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEALERGGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIA
                     HLAARKETRWHSFGENTDYPQQSKEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEK
                     GAGER"
     CDS             7644..7958
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_8"
                     /sec_met_domain="Fer4_9 (E-value: 1.7e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.5e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.5e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             7989..9107
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg40_9"
                     /sec_met_domain="PAPS_reduct (E-value: 3.9e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVIAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             9109..10749
                     /locus_tag="ctg40_10"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             11419..11673
                     /locus_tag="ctg40_11"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             11692..12543
                     /locus_tag="ctg40_12"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIVAVCMFSNVHGAEAAGPPAPKTLTVTP
                     TEKPKSTAKSKSASTSKSKSTPKSKSALTQKPEATPIPASTPTSEQEAETDKQNPADQG
                     TLSKPDHPDTISADKLVFIGDSRTEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQ
                     IEDNTAVIILMGVNDLYHVNDYVSYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEI
                     ESFNAAMQANLSGVTYIDVYSHLVSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQRSGI
                     WG"
     CDS             12766..13776
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg40_13"
                     /sec_met_domain="Fer4_7 (E-value: 6e-12, bitscore: 35.9,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 8.3e-12, bitscore: 34.5,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 1.2e-08, bitscore: 24.6,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.4e-06, bitscore: 17.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTVM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKI"
ORIGIN
        1 aagtagcaat cttcagcgac aggaagactg gtatgatcgt gaagtaatta aatgtataat
       61 ttcgattata taactggcgt attcgtgtat tatgttcata cctacataaa atccccggct
      121 cccgcagaat tggtctgcgg gagttgggga tttttgtcgt gtttgggttc tcgtcacctt
      181 gatcaccata gtaaatttct gttgcttatc ctgtcagggc atgataagct aaacatataa
      241 aatctggtat tatggggtaa tatatacagg agggcgtaat aaatgataga tataaaaaat
      301 atcagtacac actgtacgcg cagtgaattt gtaggtaaag cagtgctgga tacgatagga
      361 cttgtgattt ccggaattga tgatactttg ctcaaggaga tgaacatagg aacgaagtat
      421 cattgtctgg gattattcag ttcccgtaca ggggcagcag ggcagctgac tgctcttgat
      481 gatgcagtaa aagcaaccaa cacagaggtt ctttccatag aactgccaag ggatacaaag
      541 ggctggggcg gccacggtaa ttatattgtt cttggaggaa ctgatgtctc agatgtgcgc
      601 catgccatat ccatggcact ggagcttacc aataaaaatg caggagaggt atatatcagt
      661 gaaagcggtc atctggagtt tgcctattca gccagtgcag gacaggtact gaataaggct
      721 ttcggagtac caatgggaga agcattcgga tttatggctg gctctcctgc tgcaatcgga
      781 ctggtaatgg cagatacagc gatgaagtct gcctctcttt ctattgcaaa atatatgaca
      841 cctgataagg gaaccagtca ttccaatgaa gtgattctgg cagttgccgg tgatgccagt
      901 gctgtgaaaa cagcggtact gaatgcaaga cagatcggtc tggaacttct gatcgcaatg
      961 ggcagctatc cggagacccc gggggtacca tatttataaa aaaaatcttg acttttgcat
     1021 ccggaatcca tataataatc aacggtaaat taaagaaaca gatatttggt attattggaa
     1081 acggtacatc ctcctggatg gttatgaaca acacaaatct ctaattgatg ttattcatac
     1141 tatctaagga ggatttttat gcctaaaaac aagtttcagg aagttatttt tacgattatc
     1201 atggtgtttg taatggtcta tgccatgatc tgctacaaca ttgtactgaa tacagggaca
     1261 atgacaaatg agacatttct gttagctttt catgaattaa cattcatggg accgattgca
     1321 tttattcttg atttctttat catcggtggt cttgcaaaga agattgcatt tggtattgtg
     1381 gatatgagaa gagataatcc gttccacctt gtacttgcaa tctcagcagt atccgttgca
     1441 tttatgtgtc catgtatgag ctttgcggca actgtgctga ttaaacatgc accggcaagt
     1501 cagatcattc ccacatggct ccagacaaca gcaatgaact ttccgatggc attcttctgg
     1561 cagatctttt atgccggacc attcgtaaga tttattttcg gaaagctttt cccggagaaa
     1621 gaaaaggcag cagcttctgc cgaataaaaa atatgtaatt ttgactgcag cattctgtat
     1681 ttcaggatgc tgcttttttt gtgttcttat ctatacgtta ctgttcactc cgttctcagt
     1741 aacgtagcca aaattcattc cagattgcct gcggcaatgg aattttggct tgtatgtctc
     1801 gggattttgg catattcatg ccaaaacacc tcgcgggata gtgatgtgtg aacagtaaca
     1861 tctatacaac gtaaattgta cttattttaa tacactattg acaaattctg tcatttcttg
     1921 taatatcata taaaacatat cgaataacta tgaaaagtag agaatgcaaa aaactactgg
     1981 taccttaaag gagatgaaac atgatcagaa aattatttgc ctttggtttt gcagttgtac
     2041 tggcactgat gccggtacag gcttttggaa aaacggtgtc tgtcaccaat gtttcctatg
     2101 atcctaccag agagatgttt gaacagtata ataaaatatt tgaagaccac tggaaggaga
     2161 agaccgggga agatgtggaa gtgatacagt cccatggcgg ttcagggaaa caggcactgg
     2221 aggtagccaa tggtctggat gcagatgtgg taaccctggc actggaatat gatattgagt
     2281 ctattgaaaa cgcagggctg atcaaggcag gatggaaaga taaatttgac aatgacagtt
     2341 ctccttatac atccactatc gtatttctgg tgaagaaagg aaatcccaag gatatcaaag
     2401 actgggacga tctgacgaaa aaaggagtgg gagtagtaac accaaatccg aaaacctccg
     2461 gcggtgccag atggaactac atggcagcgt gggcttacgc agataaaaaa tatggtggcg
     2521 atgaagcgca gatgaaggaa tttatcaaga aactttaccg gaatgtggtg gttcttgact
     2581 caggcgcaag aggcgcaacg acctctttcg tggagaacgg acaaggagat gtgctggttg
     2641 cgtgggaaaa tgaagcttat ctatccatgc gggattatcc ggatgagtat gagattgtta
     2701 ctccaaacgt aagtattctg gcacagcctt ctgtggcagt ggtagatgaa gtggtggatt
     2761 acagagatac aagagatgtg gcaactgagt atttgaatta tctgtattcc gacgaagcac
     2821 aggagatcgc agcagagaat tatttccgcc ccactaatga gaaaatcctg aagaagcaca
     2881 gtgatacgtt tgatctgaat ataaatctgg caaatatcag tgattatggc ggatgggata
     2941 aagtgcagga gaaacatttc acagatggcg gaattttcga tcagatttat gagagataaa
     3001 ggaagacaag atgaagcaag agcataagca cagacagaat atatgagaca ggagaggtgg
     3061 taattgatta tgaaaaaaag aaataaaccg gtgattccag ggtttgggct ctccatggga
     3121 attaccattt ccatattgag tctggtagtt ctgatccccc tggcaagcct ggtggtctac
     3181 acagcgaagc tgagttttaa agattttatc gaaaccatca caagggccag agtgctggta
     3241 tccttttata ccagttttgt atgtgctttt gcagcagcag taataaatgg aattatggga
     3301 actgttcttg cgtgggtgct tgtgaaatat gattttccgg gcaggagact tatggatggg
     3361 atgatcgaac ttccctttgc tcttcccaca gcggtagcag gtattgcact gacatccctg
     3421 acctcagatt cgggaattgt cggcagcttt tttgcaggat tcggtatcaa gatcgcatac
     3481 acaagaatag gtattacagt ggctatgata tttgtaggaa taccgttcgt tgtgcgaagt
     3541 gtacagccgg ttctggaaaa gatggataat tcttacagcg aggcagcagg agtgctggga
     3601 gcaaagaaaa caactatctt ctggaaggtc atttttccgg aactgaagcc cgcgatcttt
     3661 gcgggaaccg gacttgcgtt cggaagatgt ctgggtgaat atggaagtgt tgtatttatc
     3721 gcaggaaata aaccctatta tacagaaatc acaccgctgg ttattatgtc agagcttcag
     3781 gaatttgatt attcaagtgc aacggcaatc gcacttgtga tgttggcagt ttcatttttt
     3841 attctgttcc ttaacagtat gatacagcag agaaatgcaa gaattttaag aggaggaaat
     3901 gcctgatgga caacaatgaa aagacttcgg agaaaattac aaaatggctg cttgtcgtga
     3961 tcagtgttct gtttctggca gtcatgctcc ttcttcctct gatcactgtg atcacagaag
     4021 cattgcggag cggatggaag gtctatgcag ctgcagtcac agatgagtac accatcaaag
     4081 cacttcttct tacagtgaag gcaacactct ttgcagttgt ttttaacact gtttttggtg
     4141 tttttgcagc ctgggcactg acgaagtttc agttcagggg taaaaagctt cttaccacac
     4201 tgatcgatct tccggttact atttcccctg ttattgcagg tttgatcttt cttctgattt
     4261 tcggacgaca gagtcctgtt tacttttttc tcatgaagtt agggatgaaa gttgtattct
     4321 ctgtaccggg aatcattatt gcaactgtat ttgtaacctt tccttttatt tccagagagc
     4381 tgattccggt tctggaagca gaaggaagcg atgaggagga agcagcagcc ctgatgggag
     4441 caggtggatg gaccattttc tggaagatca cattccctca tattaaatgg gcattactgt
     4501 acggagttgt gctctgtacg gcaagagcaa tgggagagtt tggagcggta tctgtacttt
     4561 ccggacattt aagaggaaag accaatacac ttcctcttca tgtagagatt ttgtttaatg
     4621 agtttcagta tgttccggcg tttgccgtat cttcgctgct tgtgatcatg gcggttatca
     4681 ttctggtagt cagaagcctg attgaatata aaggaaagaa ggaagcctga tatgtatgta
     4741 gagttaaaaa atatcaataa gacatatggt tcttaccagg catcaaggaa tgtgaatttc
     4801 ggaattgaga aaggtaaact gattgggctg ttgggaccaa gcggaagcgg aaaaacaact
     4861 attcttcgaa tgatcgcagg tctggaaacc ccggacagcg gagaggtcat tattgatgga
     4921 aaagtggtaa atgatgttcc ggccagtcag cgtgggattg gatttgtatt tcagaattat
     4981 gcgttgtttc gctatatgac agtttatgac aacgttgcat ttggtttgaa ggttcagaag
     5041 gctgataaga agaaaattga tgccagagtc agagaactga tcaaactggt ggggctggaa
     5101 ggactggaaa aaagatatcc aagccagtta tccggcggtc agaggcaaag ggtggcattt
     5161 gccagagccc ttgctccaaa tccccaggtg ctgcttctgg atgagccctt tgcagccatt
     5221 gatgcaaaaa tccgtcagga actgcgaagc tggttaaaag agatgatcgg gaagctggga
     5281 attaccagta ttttcgttac tcatgatcag gatgaggcca ttgaagtagc agatgagatt
     5341 attatcacta atgcaggacg gatcgaacag aaaggaactc ccataggggt ttacagaaat
     5401 cctgagacag cttttacagc gtccttcttc ggacagccat ctgtgttgaa aaatgcggat
     5461 gatttccata cctttgctca ggcagaagga gcagacaaga ttattgtccg cccggaattt
     5521 gtaaaaatct ccaaactgga tgaggtggag aagttcaaaa cttccgtatc ccagggagtg
     5581 gttgaacggg tttctttcag gggagataat ctggaacttc aggtgagagt caacaattcc
     5641 gtagtaactg ccagaagaag cctggagaaa acagatatcc gggaaggtga gactgtgaat
     5701 gtattccttt acaggatttt tgcactgaga ggtgacagtg tacagctgat cgaaaatgag
     5761 gctgtaaggg atgactttgt aattatctga caacggtggc tgcggcgact gacgacaatg
     5821 aagaaataag aaattcagag gcaagactga tcggaaaatc aacttgttgg cacactggta
     5881 tggaggaaag gataagagag aatgagaaca gagagaatca ggacagatgt gctgatcatc
     5941 ggcggcggta cggcaggatg ctttgcagcc tatgtgatcg gcaaaaaaag cggcagaaaa
     6001 gttctgatcg cagagaaagc gaatattaag cgaagcggat gtctggcggc gggcgtgaat
     6061 gcattgaacg catatattac agaaggcaga gtgccgcagg attatgtgga ttatgccaaa
     6121 aaggatgccc atggaatcgt aagagaagac cttcttctta ccatgtcaga gagactgaat
     6181 catgtgacaa aggtgatgga agatctgggg ctggtcatcc tgaaggacga aaacggaaaa
     6241 tatgttgcca gaggaaaccg aaacatcaag atcaatggcg aaaatatgaa gccaatcctt
     6301 gcaaaggcgg cagctgaaca ggagaatgtt acggttctca atcatgtaaa tattacagat
     6361 tataaaacag aaaacaaaaa agtcacaggc gcagttggat ttagcgttaa tgaggatatt
     6421 ttctatgaca ttgatgcgaa agcagttctt tgtgccacag gtggtgcagc gggactttac
     6481 agaccgaata atccgggatt ttccagacat aagatgtggt atcctccgtt taacacaggt
     6541 gcaggatatg caatgggact tctttccggt gcagagatga caacctttga gatgcgtttc
     6601 attgcattga gatgtaagga cacgattgct cctacaggaa ctattgctca gggtgttggg
     6661 gccagacagg tcaatgcaca tggtgatatt tatgaaacaa aatatggtct gacaacttcc
     6721 cagcgagttt acggtacagt catggagaac agagaaggaa acggtccatg ttatctcaga
     6781 acagaaggta tttccaaaga acaggagcag gacctttaca aagcttacct gaatatggca
     6841 ccgtcccaga ctctgaaatg gatggaagcc ggaaaaggac catccgaaga gaatgtagag
     6901 attgagggca cagagccata tattgtaggc ggacatacag ccagcggtta ctgggtagat
     6961 aataacagag ctacaactat tgaaggttta tatgcagccg gagacgtagc aggaggatgt
     7021 ccgcagaaat atgtaaccgg cgcactggca gaaggtgaga tcgcagcaga ggcgattttg
     7081 gaatatctga atggcaaaga tgatgaccgg atcgcagcgg aaaataagga agaggcttta
     7141 gagcgtggcg gagaacagga gctgtctcaa actgcaatag ctaagaaggc agaatacgaa
     7201 tcacatttga atgcttcccg ttctttgatg aatgcagagc agcttgagga agccatgcag
     7261 aagatcatgg atcagtacgc aggaggaatc ggtacagact acagatacag cgggatgagt
     7321 cttgcaaagg cagatgaaaa gatcgcagca ttgttgccag tagttgacac tctggcagca
     7381 acagatactt atgaactgat gcagatttat gaacttcgcg aacgactgat cgtgtgccag
     7441 gcagtgatcg cacatctggc agccagaaag gaaaccagat ggcatagttt cggagagaat
     7501 acagactacc cgcagcagag caaagagtgg atgaaatatg taaactcccg tatggaaaac
     7561 ggcgagatta agatcttata tcgtgacctg atcacaaagg aaaatacagg tttgaataca
     7621 gcagagaaag gagcaggtga gagatgagca ttcggattca gaaaagtaaa tgtgcaggat
     7681 gcggcagatg tatcgaagcc tgtcccggaa atctgatcaa aaaggataaa gagaacaaag
     7741 cctttatccg gcaggtaaga gactgctggg gatgtacttc ctgtattaag gaatgcaggc
     7801 atgatgccat ccgctttttc cttggagctg atgtgggagg cagaggtgca agtatggttg
     7861 tatcagagaa accggatatt tccacatgga cagtggagaa gccggatggc actaagatca
     7921 ctattcaggt taataagaaa gacgctaata aatattaaac ataagtatgt attctcggag
     7981 tctttagagt gtgtttgaaa aatgctttac gcaagatgtg cgtcacaatt tgtggaagat
     8041 tttgttcgga tgagggcgtc atagcgggct acgacaaccg aattcggaca aaatataccg
     8101 caaagtgggg cgtgcagatt gcgggaatga tttttcagac acgctctagt gtatttgctc
     8161 aagtacgaaa agattccgag tataaacaaa cagaggagga taatgcaatg agtaacttat
     8221 ctcatcttga tgcgcttgag gcagaggcga tttatattat gcgagaagta gcagccgagt
     8281 gtgaaaagcc ggttatgctc tattctatag gaaaggacag ctccgttatg ctccatctgg
     8341 cgatgaaggc attttacccg gagaaacctc cattcccgtt ccttcacatt gatactacat
     8401 ggaaattcca tgagatgatc gaattccgcg acagaatcgc aaaggaaaac ggaattgata
     8461 tgctggttta caccaatgaa gagggtgtaa aggcaggaat caacccattt gacaatggtt
     8521 ctgcatatac agatatcatg aaaacacagg ccttaaaaca ggctctgacc aaatatggat
     8581 ttacagcggc atttggaggc ggtcgtcgtg atgaggagaa atccagagca aaagaaagaa
     8641 tcttctcttt ccgtaattca gctcaggcat gggatccgaa aaaccagaga ccggagatgt
     8701 ggaagcttta taacactaag atccagaagg gcgagagtat gcgagtattt ccaatttcca
     8761 actggacaga aaaggatatc tggcagtaca ttcagcgtga aaatatcgaa attgtaccgt
     8821 tatattttgc gaaagaaaga ccggtcatct acagagacgg aaatatcatt atggtggatg
     8881 atgacagatt aaaactccgt ccgggtgaaa agattgaaaa caaaaaagtc agattccgta
     8941 ctcttggatg ctatccgctt actggaggta ttgaatctga agcagatact ctggatgaga
     9001 ttattgatga gacattaagt gctgtttctt ctgaacgtac cagcagggtg atcgaccacg
     9061 aggcagcagg cagcatggag agaagaaaga gagaggggta tttctagaat gaaaggatta
     9121 ttgaaattta ttacatgcgg aagtgtggat gatggaaaat ccactctgat cggacatatt
     9181 ctttatgatg caaagcttct ctatgcagat caggagaaag ccctggagct ggattccaaa
     9241 gtaggaagca gaggcggtgc cattgattat tctcttcttc tggacggtct gatggcagag
     9301 cgtgaacagg gaatcaccat tgatgttgca taccgttatt ttacaacaga taacagaagc
     9361 ttcattgttg cagatacacc cggacatgaa gaatatacaa gaaacatggc agtgggtgcg
     9421 tcctttgcag atctggcagt tatcctggtg gatgcttcac agggagtact ggtacagaca
     9481 agacgtcatg caagaatctg cgcattgatg ggaatccgtt actttgtatt tgcagtaaac
     9541 aaaatggatc ttattgaata tgatgaaaaa cgtttccgcg acattgagaa tcagatcgca
     9601 gcactgatag aagaactgaa acttgccaat gtaactatta ttccggtatc tgccacagaa
     9661 ggtgacaacg ttacaaccaa atctgacaac atgccgtggt ataaaggtga ggcgcttctt
     9721 tcccatctgg aaaccgtaga cattaaggaa gatacagaga agggcttcta tatgcctgta
     9781 cagagagtct gcagaccaaa ccatgagttt cgcggattcc agggacagat tgagaatggt
     9841 gccatcaggg caggcgacct tgtgactact cttcccagta aagaagaagc tcatgtaaag
     9901 agtattcttg ttggcgataa agaagttcag gaagctgtac agggacagcc tgttaccatc
     9961 cagcttgaca gagaagtaga tgtttcccgc ggatgtgtac ttaccattga ttccggcgca
    10021 gttcttacag actctgtgga agcagatatc ctctggatgg atgacaatgc tcttacggat
    10081 ggcaaaaact tctttgtaaa aatcggtaca aagatgatcc ccggcctggt tacaaaaatc
    10141 aattattctg tggatgttaa tacaggtgaa aagaaaagcg catatacctt aaagaaaaat
    10201 gagattgctt cctgtactct ggaattctcg gagaagatcg ttgtagacga atttgacagg
    10261 cacagaacac tgggtgagct gattctgata gatcgtgtca caaatatgac ttctgcctgc
    10321 ggtgttgtga gaaaaacctt tgtttctcag gatagatccc agatcggaaa agtggacgag
    10381 caggttcgtg caggactgaa aggtcagaca ccggtagtag tggaattccc gatcggtaaa
    10441 gaaggaatca ctcttgattt tgcagagcag gtagaaaagg gactgactgt acttggaaaa
    10501 catacctatc tgtatcatcc ggcagcgagt gaaaactatg cagaaactgt ccgccatctt
    10561 aaggcagcag gtctgatcgt acttcttgtt cttgatgaaa atacagcaaa agacgagaca
    10621 ttaaagactc tggatggttt ctatgcgaac tggcagattg acggaatcac tgtgaaagat
    10681 gcgattgatt tcgtgaaaaa gaaatctgca tttacagtgc agagtgtaca tgatggaaat
    10741 tatatctgat tataacaggg ctataaatcg ccgcagagac aaagaaagtc tctgcggtat
    10801 tttgttttct tgacaagtgt tgttacagcg gattatactt attttcaaat attcagaatc
    10861 cataataata cagacaggaa agataacaga aatatgcaaa cgaacaatga aagtaaacaa
    10921 aaccaaaaaa agagatgatg cttggaactt tgtttgtaat tgctacgatc atcatcctgg
    10981 cgataccaac gaagaaaaga cagaaataaa gatgagtgaa tatcgatcag aatgtagaat
    11041 gggcaattgg ttactgttca cacaccacta tcccgcgagg tgttttggca tgaatatgcc
    11101 aaaatcccga gacatacaag ccaaaattct attgccacag gcaatctgga atgaattttg
    11161 gctaagttac tatgaacgga gtgaacagta acggcaattg tgaagtggca ttcagattac
    11221 atattatgca gcagagtatg atataattcg ttttgtataa tggcgtcagg attaagagca
    11281 tatgtagagc tgtgtagcga agcggattgc gaatatctgt ttgacttttg atgggtgtac
    11341 acgagaacat ttttttacag tgaaagttat ctgtattata ttacagaggg tactgtacag
    11401 ataatcagga ggtattttat gcgtttggaa aaagtacagg aagcgttaaa aacaaagaaa
    11461 attcattatg aatatacaga ggaaaatgga tgcggaagca tcgactttat gtttcgcggt
    11521 ctgagattcc atatatggga atatgaagat cgtgtctggg gagcggagac aaacgtgttc
    11581 gaagcaggca gaagccagga tattgaagga gattacgagg aaattatttc cggagaaatc
    11641 ctctcatggc cggatatgct gcctgggatg taagtattac tgcagaaggg aatgatattt
    11701 acgaaaaaat atagaaccgg acaaattgta ttaactgcat gtattgtagc tgtctgtatg
    11761 ttttcaaatg tccatggggc agaagcggca ggtccgccgg caccgaaaac tctgacagtt
    11821 acaccgacag aaaaaccgaa atcaacagca aaatcaaagt ctgcgtcaac atcaaagtcc
    11881 aaatcaacac cgaaatctaa atcggcacta acacaaaaac ctgaagcaac accaatacct
    11941 gcatctactc caacatcaga gcaggaagct gagacagata aacagaatcc ggcagatcag
    12001 ggaactttaa gcaagccaga tcatccggat actatctccg cagataaact ggtatttatc
    12061 ggagattcca gaacagaggg attgagggat gcggtaaatg atgacagcat ttggtcctgt
    12121 ctttcttcta tgggatatga ctggatggta tctacaggag tgcctcaggt agaagatcag
    12181 attgaggaca atacagcggt tattattctg atgggtgtta atgacctgta tcatgttaat
    12241 gactacgtta gctatattaa ttccaaagct gccgaatggg gaaacagggg agcgcagact
    12301 tattttgtgt ctgtaggtcc ggtgcagaat gatccctatt gcagtaatgc ggagattgaa
    12361 agtttcaatg cggcaatgca ggcaaatctg agcggggtta cctacataga cgtatattcc
    12421 catctggtat ctgagggatt ttccaccgta gacggaaccc actatccgga cagtgtgtct
    12481 gtagatattt ataattatat tctggatcat ctggaggaac agaggagtgg aatctgggga
    12541 tgatttttta gtttatgaaa ttgtgatgct gtattgagtt cgatggagtt tggtgatatg
    12601 attgcagagg aaaaaacgaa atagagcgga aattcgtttt tatataaaag ctgaaaacct
    12661 ggtaggagga aataatgagt ggctgttttg cagcagagcc aaaaatgtaa atgataattg
    12721 cccgatgact ggacagttat caaaatccaa aatcaggagg aaagaatgag aggactgtat
    12781 tcatccaaaa cagaaatcag acacaaaatt tttacggaaa ttgcgaggat ggcatatgaa
    12841 ggccagtctc cggagatgct ggaagagctt ccctacaaga ttgtacccgg tgaaattgcg
    12901 acttatcgtg acagtatttt tctggaaaga gcggtagttg gtgagagact tcgcgttgca
    12961 atggggatgt cactgagaaa ggttacagag catgcgccaa tctccaaagg tgtggaggcc
    13021 agcgttattg aggaaaagta ttatgaaccg ccgcttatca atgtgatcaa gtttgcctgt
    13081 aattcctgcc ctgagaaaag ggtaatgatt acagagggct gtcagggctg tctggagcat
    13141 ccctgtgtgg aggtctgtcc aaagaaagca gtacatatgg aaggcggcag atcacatatt
    13201 gatgaagatg cctgcatcaa atgcggaaag tgtctggaag cctgtccgta taatgcaatc
    13261 atcaaacagg aacgtccctg ttcaaaggcc tgcggcatga atgccattgg ttctgacgaa
    13321 tacggaagag cagagattga ccaggacaaa tgtgtatcct gcggccagtg tctggtgagt
    13381 tgtccgttca gcgctattgt agacaaagga cagattttcc agactgttat ggcattaaaa
    13441 agtgaaacac cggtgtatgc aatcgtggcg cctgccattg caggtcagtt cccaggtatg
    13501 gagaataata agatacgggg tgcatttcag gcacttggct ttacagatgt aagagaggtt
    13561 gccgtcggtg cagatctgtg cacagtggag gaggcaaagg actttttgga ggaagttcct
    13621 gagaaacttc cgtttatggc tacatcctgt tgtccgtcct ggtctatgat ggctaagaaa
    13681 ttattcccgg aacaggcgaa atgtatctct atggcactga cacctatggt tctcactgca
    13741 aggctgatca agcagaagga accagattgt aagatc
//
