LOCUS       c00173_gnlPro..        14832 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJENKGDL_173.
ACCESSION   c00173_gnlPro..
VERSION     c00173_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:28:34
            Original ID  :: gnl|Prokka|CJENKGDL_173
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14832
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14832
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1895:7218]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1896..7218
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14832
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14832
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(303..1784)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg173_1"
                     /sec_met_domain="HI0933_like (E-value: 3.7e-128, bitscore:
                     417.3, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPVVHIYIDCSEAETWNHDEIDNLQGKINTGEYSMSKVIIIGGG
                     AAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKF
                     LYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHL
                     HTAVQEIVKKPVTESVTDSVNTLESEAALTESGSDAGKSKKGKKSPDIPQEKITGVILT
                     DGTFMEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKL
                     QGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSA
                     YLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHD
                     ISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGE
                     VLDLDAVTGGYNLQIAWSTAYLAAQAIRYCSLCSQ"
     CDS             complement(1896..3308)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_2"
                     /sec_met_domain="HMGL-like (E-value: 4.3e-47, bitscore:
                     150.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 4.8e-59, bitscore:
                     189.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGY
                     HAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTD
                     IAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLK
                     AVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDE
                     ALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGD
                     EKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDE
                     KAADKKNGAYPV"
     CDS             complement(3451..4599)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_3"
                     /sec_met_domain="OAD_beta (E-value: 5e-157, bitscore:
                     511.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEP
                     LLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTD
                     FGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKL
                     GQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVI
                     TIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSA
                     EAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARV
                     SQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV"
     CDS             complement(4616..4984)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.1; E-value:
                     5.3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1e-20, bitscore:
                     63.1, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAA
                     APAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVIILESMKMEIPVVAPQDGTIASI
                     DVAEGASVENGDTLATMN"
     CDS             complement(5012..5734)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_5"
                     /sec_met_domain="OAD_gamma (E-value: 7.6e-28, bitscore:
                     86.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQL
                     KDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEK
                     AEANFVYVFDSQGKPTSMTVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFR
                     FIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGT
                     TTDGFVVRSIRKVKRNRR"
     CDS             complement(5782..7218)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg173_6"
                     /sec_met_domain="CT_Vparvula (E-value: 1.3e-136, bitscore:
                     445.7, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPS
                     DGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAG
                     IRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGK
                     MFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDT
                     DNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGAT
                     VGAVANRSEVYDAEGKKTETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMAT
                     LCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEI
                     GMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIG
                     AFEMLFTKREDRPSKKHGTV"
     CDS             7730..9679
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) baiH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg173_7"
                     /sec_met_domain="baiH (E-value: 1.2e-141, bitscore: 462.8,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIKNRIVMMPMGTNYGEQNGEMSFLHINYYKERAKGGTGLIIVE
                     NASVDSPQGSNGTTQLRIDHDNYLPRLYKFCEEIHKYGTCIAIQINHAGASAVSARTNM
                     QPVSASDIPSKEGGEIPRPLSVEEIHHIVKKYGEAAKRAQAAGFDAVEIHAGHSYLISQ
                     FLSPLTNKRTDEFGGSVENRTRFCRMVIEEVRKQVGPFFPIMLRLSADELMEGGNTLED
                     TLEYLEYIQDEVDIFDVSCGLNGSIQYQIDANYMKDGWRSYMPKAVREKFGKPCISMGN
                     IRNPKVAEQILADGDADLIGMGRGLIAEPAWVNKVATGRECDLRKCISCNIGCAGNRIG
                     FNRPIRCTVNPAVLEGDVYKNQKVNKNCNVVVIGGGTAGLEAACTAAEVGCNTFLLEKG
                     ETLGGLASVISKIPAKKRLADFPNYLIHRAEQLENLYIFTNTEGTPENIRKFHPNLIVS
                     STGSAPLLPPIKGLHDRIDKEGSKVASILGMINHINDYPEDMTSKKVVVVGGGAVGLDV
                     VEFFAARNAEISIVEMMDQIGRDLDPVTKNDMKDQMKKHHVAQLTKTALQEVKDSSFLV
                     KDAEGERELPFDYGFVCLGMRAQGQLFAELSDAFVSDDVEILNIGDSKRARRIIDGTLE
                     GRNILNTLTQMGYL"
     CDS             9719..10597
                     /locus_tag="ctg173_8"
                     /transl_table=11
                     /translation="MAERITGHTELIGLMAYPIRHSSSPAMQNEAFAKLGYDYAYLAFE
                     VGADEIEDAVKVIRTLKMRGSNVSMPNKTLVGKYLDELSPAAELCGAVNTIVNDNGHLT
                     GHITDGIGFMSALKDNDIDVIGKKMTIVGAGGAATAIEIQAALDGVAEITIFNRKDEFW
                     NRAVSTVEKINAKTSCHAVLYDLADLDKLKAEMDDSFIFVNATGVGMKPLESQSVVPDK
                     SYFRPELIVIDVPYSPLETKMRSMAKEVGCKTMNGLGMMLFQGSAAFELWTGEPMPIEH
                     MKEILHISYDD"
     CDS             10866..11627
                     /locus_tag="ctg173_9"
                     /transl_table=11
                     /translation="MNTVQVKNTVIGEGRPKICVPIVGKTKTDILEEAKKITTLPVDVV
                     EWRIDWFDDVFATEKVLETAKELQEVLKDIPVLLTFRTSKEGGEKEISVNDYAALNIAA
                     AQSGYVDLIDVEAFTGDEVVKTIINAAHEAGVKVIASNHDFFKTPEKEEIIRRLCMMQE
                     LGADIPKIAVMPTCKQDVITLLSATLEMSEKYADRPIITMSMAGTGVVSRLTGETFGSA
                     LTFGAASKASAPGQVGVHELKQVLDIIHSSL"
     CDS             complement(11808..13166)
                     /locus_tag="ctg173_10"
                     /transl_table=11
                     /translation="MAHTRTQRRENELPYIPFGPFQIRLPFIHYKIESVEFIQGLILGV
                     TALAAVPYLEQYLGLPYELAWSCVIIETFLYLLHSLLGDPVVPGWITPTLPLTIVFLEG
                     FPMGEERIQAMIALQMLVGLVFIFMGVTRLADKFVHAVPNSVKGGILLAAPVTVMAGQL
                     GENGNMHKYPLAIVAGVGLLILISFSDKYQEKRKTNKFLDLVARYGNLFPYLIAMVVGL
                     LVGELDAPGLEIGTFIKIPQFKDIIDQVSIFGVGIPSASMFIKALPLALVCYVIAFGDF
                     VTTETLVSEARHARDDEYIDFNSSRSNLVSGLRNLILSIIAPFPPLSGPLWVGMTVSVS
                     MRYKEGKKAMKSLLGGMASFRLATFLSVLIIPVVSFFRPIFGVGSSITLMFQAFVCARI
                     GMDYCKSDRDKMIAGVMAAVLAAQGTAWASAWALAVGFGLNIFLSNWNPFEKK"
     CDS             complement(13458..14657)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 49.7; E-value: 8.8e-16)"
                     /gene_kind="transport"
                     /locus_tag="ctg173_11"
                     /sec_met_domain="MFS_1 (E-value: 1.7e-16, bitscore: 49.7,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQKTNKMLIFTSLAAYFTYFIHGIGASILGQYKPEFAAAWGAKP
                     LADGTLDVSMVVSVIAALGLGRLISLPFSGPLSDKYGRKLSGIIGVLCYVAYFFGMANS
                     TSMAMGYAFAVIGGIANSFLDTCVSPTCMEIYVNNPSVANLFTKFSICLSQFLLPFLIG
                     IVASANMSYKTIFIVAGIAILIDGILILILPFPAREKAVQAKADKKKSGHKISPAAIAA
                     ILIGFTSSSTFMLWLNCNQELARSYGMADPSKIQSLYALGTATAILATAAFIKKGLKEI
                     SVLILYPLISTIMLALCYFIQAPFICLVGGFVIGYAGAGGVLQLAVSTTAEFFPENKGT
                     ATSLVMIASSIANYTILSLAGYITKVGGSSAPRMILLLNMAVTIVGILLALFVKKNRNQ
                     "
     CDS             complement(14678..14830)
                     /locus_tag="ctg173_12"
                     /transl_table=11
                     /translation="VKEAKEAGCKLAIGGKGMLLWQGAAAYKLYTGLEMPTAEYQKFQE
                     ENENK"
ORIGIN
        1 gtcgatggct atgttacatc ccattttcgt ggttcctcct gtttctatta ttcaaacaga
       61 ttttctctgt tttattatta attaatgttt atgaatcgtt aaataacgta tagcagaatc
      121 atatcataga tatcatccac ctacaaggta ctcatcatct gcttgtttca gcttactgta
      181 tagccgttac tgttcacaca tcactattcc gcgaggtgtt ttggcatgaa tatgccaaaa
      241 tcccgagaca tacgagccaa aattccattg ccgcaggcaa tctggaatga attttggcta
      301 cgttactgtg aacagagtga acagtaacgt atagcctgcg ctgccagata tgcggtagac
      361 caggcaatct gtaagttata tccacctgtc actgcatcca gatccagcac ttcgcctgcg
      421 aagtaaagac ctgagatttt ctttgattcc attgttccgg ggttgatctc tttgacagag
      481 acgccgcctc tggtgatgat ggcttctttg aactcaccca ttcctgtgat tgtgaagggg
      541 aaggctttga taaggtcaat gaagtgctgg cgttcttctc tggagatgtc gtggattttc
      601 ttctctgcgg ggattccacc cagttccagc attaccggag tcagagatga cgggaaaagt
      661 acgccaatca cgttcttgaa ctgtttgttt ggtcctgctt caaattcacg caggatcctg
      721 gcatccagct gttctctggt aagtgccggc ttcagatcca gatatgcaga cagttcgccg
      781 tttggtgctt tcgccagttt tgcaccaatg tgggcactgg cggacaggat catgggacct
      841 gtgactccga aatgggtgaa catcatctct ccgaaatcct catagagtac tttctttcca
      901 ttctttatgg taagtcctgt attcttaagg gaaagtccct gaagcttagg gatatagtct
      961 tcttttgtct ttaatgggac aagagaaggt gcaatgtctg tgaccttcaa tccaagttct
     1021 cttgcaaagc ggtatccatc gcctgttgag ccggtgctct gataagagaa tccgccggtt
     1081 gccacgatga ctgcatctcc ttccatgaag gttccgtctg taaggatgac tcctgtgatc
     1141 ttctcctgcg gtatgtcagg tgattttttt ccttttttgc tttttcctgc atcagatcct
     1201 gattctgtta atgcggcttc tgattcaagg gtatttacgg aatctgttac agattccgtt
     1261 acaggtttct ttacaatttc ctgtacagca gtgtgaagat gaatctttgc tcctgctttc
     1321 ttcagttcac gttccaatgc gcggatgatg tctgaggaat ggtcagactg tggaaatacg
     1381 cggtttccac gctctacctt cagagggaca cccgctttct caaagaactc cattacatcc
     1441 tgaggggtaa atgaatagaa actgctgtag aggaacttgg gattgctcat cattgcagga
     1501 aagagttctt ctgtgtcgca ggcatttgtc acattgcatc tgccttttcc tgtgatgaag
     1561 actttctttc ccagtttctc gttcttctct aatatatgaa cttcatgatg gttacgggct
     1621 gcaaaaaccc ctgccatcat tccggcggct ccgccgccga ttattataac tttgctcatg
     1681 gaatattctc ctgtatttat tttaccctgc agattgtcta tttcatcatg gttccacgtc
     1741 tccgcttcgc tacaatcaat atagatatgt accactggca gcatataccc attggcacat
     1801 tatattcccg ggtatcatat tctttcataa taacgcaaag gagcctgctt acgcaagctc
     1861 cttttttcgt ttggacatat ttaattactg atcaattata caggatatgc tccgttcttt
     1921 ttgtcagctg ctttctcgtc aacttttgtt ttctgagcct gacggtattt gaagaagtcc
     1981 atagctacct gtgggaacag tgcgtatgtt aatacgtctt catcctgttc cttgtactga
     2041 gccatttcgc tctcaagttt ctcaagctcg ttgtcaagaa ggtctgccgg acggcatgtg
     2101 atcggtttct catcgccaat gcacttcttc tgtacttccg gattaaacgg ttttacagtt
     2161 gcgccgtatt ttcctaacag gatatctttt gtttcttttg taaccatttt gtatctctcg
     2221 cccataagta cgttgaatac agcctgtgta ccaacgatct gtgaagacgg agtaacaagt
     2281 ggcggttcac caaggtcttt acgtacacgc ggaacttcct cgagaacatc gtagaatttg
     2341 tcttctgcgt gctgttcttt cagctgggaa gtcaggttgg agagcatacc gcccggtacc
     2401 tggtacagta aagttttgat gttaacacca aggttcttcg gattgagcag tccgctgtca
     2461 agagcttcgt cacggatcgg acggaagtag tcagcgatct cggagagaag cttctgatca
     2521 aatcctgtgt cgtatggtgt atctttgaat gtctcaacca taacctctgt tgcaggctgg
     2581 gatgttccca gtgcaaatgg agacattgct gtatcgataa tatccacacc tgcttctact
     2641 gcttttaagt aagtcatgga agctacacca gaggtgtaat gtgtatgaag gtcgatcggg
     2701 atcttaactg tttcttttaa tgctgtaaca agctctgtag ctttgtttgg aaggagaaga
     2761 cctgccatat ctttgataca gatggaatca gcgcccatat cttcgatacg ttttgcaatg
     2821 tctgtccagt attccagtgt gtaagcatct cctaatgtgt aggaaagagc tacctgtgca
     2881 tgagccttct ctttgtttgc agcgcttact gctgtctgca ggttacgaag gtcattgagg
     2941 cagtcaaaaa tacggatgat gtcgattccg tttgcagcag atttctgtac gaagtattct
     3001 acaacgtcat ctgcgtatgg acggtatcca aggatgttct gtccacggaa aagcatctga
     3061 agttttgtgt ttttgaagcc gtcacgtaat ttacgaagtc tttcccatgg atcttcgtgg
     3121 aggaaacgaa gggatgcatc gaatgttgca ccaccccagc actctactgc gtgatagccg
     3181 actttatcaa gtttatctac gatcggaagc atctgttctg tggtcatacg tgttgcgatc
     3241 tgggactgat gagcatcacg gagaatggtt tccacaattt taacaggttt tttctctaat
     3301 tctgccatta ttaaatctcc tttatagttc tgtttaatcg gatattcgca atccgcttcg
     3361 ctacttgctc ataaccaaat agctgctccg cagcttatca gaaggagttg cactcctcct
     3421 gatacaagca agatagcttg cttgatttgg ttatactccg aaaatagcca tgaatgttcc
     3481 ggctgctacg gctgtaccga taacaccggc aacgttcggg cccattgcgt gcatcagaag
     3541 gaagtttgta ggatctgcct ctgcacccac tttctgggat acacgggctg ccataggtac
     3601 tgcggataca cctgcggaac cgatcagcgg gttgatcttt ccatgagtca gtttgcagag
     3661 cagtttacca agcatacatc cgccgaatgt accgattgcg aatgcaacaa gacctaaaac
     3721 tacgatcttc agagtatctg cgtttaagaa tgcttctgca cttgtggaag cacctacgga
     3781 tgtacccaga aggataacta cgatatacat cagggcattg gatgctgttt ctgtcagctg
     3841 ttttacaaca ccgcactctc tgaacaggtt accaagcatg agcataccaa ccagcggagc
     3901 tgttgtaggc aggatcaggc agacaacgat tgtgataacg atcgggaaca ggatcttctc
     3961 cagtttggaa accgggcgaa gctgatccat tttgatctta cgttctttct ctgttgtgca
     4021 gagtttcatg ataggcggct ggatgatcgg aaccagtgac atataggaat atgctgccac
     4081 tgcgatcggt cccatcagtg cagactgtcc aagtttacct gcaaggaaaa tggaagtcgg
     4141 gccatcagca ccaccgatga tggagatagc tgctgctgct tttccgttga atccaagaaa
     4201 gattgcaagg aagtaagctg catagatacc aagctgtgct gcagcaccca tcaggaagct
     4261 gatcgggttt gcgatcagcg gaccgaagtc tgtcatggca cctacaccca tgaagatcag
     4321 ggatggtaag atactccact catcaaggat gtagaaataa tgaagaagtc cacctacacc
     4381 attagacata tcttccgggt ttgccataat gtccggatag atatttacaa gcagcatacc
     4441 gaatgcgata ggaacaagca gaagcggctc gaatcctttc ttgatagcaa gataaaggaa
     4501 tacgcaggct actgcgatca tcaggtaatt gccccatgtc agattgaaga atgctgtctg
     4561 gtgaatcagg ttggacaatg tttctgttac ataagacatt tgactacctc ccgtcttagt
     4621 tcattgttgc taaagtatct ccgttttcta cagaggcacc ttctgcaaca tcaatgcttg
     4681 cgatagtacc gtcctgagga gctactacag ggatttccat tttcatggat tcaagaataa
     4741 ttacgctgtc tccggctttt actgcctgtc caacgcttgc tgctactttg acaactttac
     4801 caggtacgga agcagttact tttactgcgc cggcgcctgc tgcaggagct gctgctttcg
     4861 gagctgctgc aggtgcagcc ttaggtgctg cttttggagc tgctgcagga gcggatacgc
     4921 ttcctgtttc ttcaacagtt acttcatatg ctgtaccatt tactgtaatt gtatagcttt
     4981 tcattttaaa atcctcctaa ataaatgaca attatcttct atttcttttt actttacgga
     5041 tggaacgaac tacgaagccg tctgttgtag ttccttctgc tgctgcgatg gctgctgcga
     5101 taacagctac cagctctccg tcatctgcaa ggttctcttc tgcctgtgca ggtgctgtct
     5161 gtgcgatggc tgctgcctct gcctcttttg cagctttggc tgcttttgct tctgctgctt
     5221 tctttgcttc cggattcgga ataaatctaa acagagaaat cagaaggctt aataaaatca
     5281 gcattacgaa tacagttcca atacccatca aagtattaag gcctgctctc tgaagagtct
     5341 tgcccatacc atactgtaca tctacagtca tggaagtcgg ttttccctgt gagtcaaaga
     5401 catatacaaa gtttgcttct gctttctcaa atttaagagg aacagtaact gtgtactgat
     5461 catctttgaa agttacagta gtttcaccat tgctgtcctt ctttgcgcca agttcatcct
     5521 tggatgtctg ccaggactgc atggcacttg ttgtaaagtc atctcctgaa ctcatgtaat
     5581 tctcgatttc ttcatcttta agctggacaa tggcatctgt cagtccttct gctgtagtta
     5641 ccagtgtgga cttaacagta tcatcaacct tatctgcggc aaataccaca gaggtgctgc
     5701 caatcaccag cgcagccatt acgagaaatg tcatgaatac agaagttatt tttttgatca
     5761 ttttcatatg cgtcaccccg cttagaccgt tccatgtttc ttagacggac gatcttctct
     5821 ctttgtgaac agcatctcaa atgcaccgat tacatatttt cttgtgtcag ccgggctgat
     5881 cacagtgtca acatagcctc ttgctgctgc ggaagcaaca ccattctgaa gctctctgta
     5941 ctgagcagct ttttcattca gttcagcagc atctgcatct gcatacatga tcttggctgc
     6001 cagggaagca tccatcatac cgatctctgc gttatcccat gcatatacaa ggtctgcacc
     6061 gatagatttg ctgttcattg ccacgtaagc tgtaccgtaa gctttgccga tgatcacatt
     6121 taccttcgga acagttgcat ctgcgaatgc agctaccagt tcacctacgg atttcgccat
     6181 catcttctcg ctgcataagg ttgccatgaa gcctgttgcg tttgtaagtg taagtaccgg
     6241 aatatcaaaa gcgtcgcaga atttcacaaa atctgctgct tttcttgcgc ctcttgcaga
     6301 gatgcttccg tcaaatgttt ctgttttctt gccttctgcg tcatatactt cgcttctgtt
     6361 tgcaacagca cctactgtag cgccgtttaa acggataaag cctgtaacca tgtcttttgc
     6421 atagtctgct tttgtctcga agaattcacc gttgtcagcg atctgggaaa gtgcgattgc
     6481 tgtgtcacct gcacagtttg caagatctgc gcatacgcgg ttaagatcat ctgtacactc
     6541 tgtgtaattg tctgtgtctt cattattaga aggaagaagt gatactaagg aacggatctg
     6601 gccaagaatc tcatcctctg taccaacgcc atcgatcaca cctgtctctt tgctctggaa
     6661 atcagctgct gctgtgtcgc atttgtctgt gttgtttcct tccagtgcgt ttggtgtgtt
     6721 gacgaacatt tttccttttt tggattccat gaatgtgaaa tctgtcaggg acgggataac
     6781 tgccatacca ccgccgcatg ttccgaagat tgctgtgatc tgcgggatca caccggatgc
     6841 cagtgtctgt ttcagataga tctgtccgaa agcttccagt gcgtctgttg cttcctgaag
     6901 acggatacct gcacagtcaa caagtccgat aaccggagcg cctgttttca tggcaagatc
     6961 ataaagtctt gtgatcttct ttgcatgcat ttcaccaaca gtaccgttta atacagatgc
     7021 atcctggctg tatacataaa ccagtttgtc atcgatcaca ccatatccgg tgataacacc
     7081 gtcagatggt gccttgtttg cagtcatgtt gaaatctgtg gatctggctg ttacaccctg
     7141 tccgatttcg acaaaactgt ttgcgtcaag caaagaagta attcttgtgc ctgctaagct
     7201 ttgtgttgca ttactcattc ttgtttgccc tccatcttta tgagaatatt taaaagttaa
     7261 cccaaaaatt tagccgattt taattttacc ttttccggca gaaaatttca acatttattt
     7321 gtcattttcg ttaaaaatat agcagaaaaa tttgtcaggt ttctccaaat tttgtttttt
     7381 tgagtatttc ttcctattta atagagggta ttacggttat tttgtattgt cccgtatttc
     7441 accctctccc gcaaaccaga gcgtgtttga agtaactata ccactcactt gtctgcaaat
     7501 ccgactacac aggtataaaa gtctcagcaa aaccatagat gttttttatt atatagcacg
     7561 aattatcaat tagatttatg gattatcccg ttatataatt aacacatcaa agaaattcag
     7621 gccacagcta aagcactgaa cagctataga tccaacagaa aatttcagga ggaaagacgt
     7681 aatgaaaagc aattaccagc atattttcac accactcaca gtaaaaaata tgactatcaa
     7741 aaaccgtatc gttatgatgc ctatgggaac caattacggg gaacagaacg gcgaaatgag
     7801 ttttcttcac attaattatt ataaagagcg tgccaaaggc ggcacaggtc tgatcatcgt
     7861 agagaatgca agcgtagatt ctccgcaggg ttccaacgga actactcagc ttcgtattga
     7921 ccacgacaac tatctgccgc gtctgtacaa attctgtgaa gagatccaca aatatggtac
     7981 ctgtattgcg atccagatca accacgcagg tgcttccgct gtttccgcac gtacaaatat
     8041 gcagccggtt tccgcatctg atattccgtc caaagaaggc ggagagatcc cgcgtccgtt
     8101 atcagtggaa gaaatccatc acattgtaaa gaaatacggc gaggctgcaa agagagccca
     8161 ggctgcaggt tttgacgcag tagaaatcca tgcgggacat tcctatctga tcagccagtt
     8221 cctctctcct cttacaaaca aacgtacaga tgagttcggc ggatctgtgg aaaacagaac
     8281 acgtttctgc cgtatggtca ttgaagaagt aagaaaacag gtcggacctt tcttcccgat
     8341 catgctccgt ctcagcgcag atgagctgat ggaaggcggt aacactctcg aggatactct
     8401 tgaatatctg gaatatattc aggatgaagt tgatatcttc gatgtttcct gcggtttaaa
     8461 cggttctatc cagtatcaga tcgatgccaa ctacatgaaa gacggatggc gttcctatat
     8521 gcctaaagct gtcagagaga aattcggcaa accatgtatc tccatgggaa atatccgtaa
     8581 cccgaaggtt gctgagcaga tcctcgctga cggcgatgca gacctgatcg gtatgggacg
     8641 tggtcttatc gcagaacctg catgggtaaa caaagtagct acaggcagag aatgtgacct
     8701 tcgcaaatgt atctcctgta acatcggatg tgcaggaaac agaatcggct ttaaccgtcc
     8761 gatccgctgt actgtaaacc cggctgttct ggaaggtgat gtttataaga atcagaaagt
     8821 gaacaagaac tgtaacgttg tagtaatcgg aggcggtact gccggactgg aagctgcctg
     8881 tacagccgca gaagtaggct gtaatacctt ccttctggaa aagggtgaga ctcttggcgg
     8941 tcttgcttct gtgatctcta agatccctgc aaagaagcgt ctggctgatt tcccgaacta
     9001 tctgattcac agagcagagc agcttgagaa tctttatatc tttacaaaca cagagggaac
     9061 accggaaaat atccgcaagt tccatccaaa cctgatcgta agctccacag gttccgcacc
     9121 actgcttcct ccgatcaagg gacttcacga ccgcattgac aaagaaggca gcaaggttgc
     9181 ttctatcctg ggaatgatta atcacatcaa tgactatccg gaagatatga caagcaagaa
     9241 agttgttgtt gtgggcggcg gtgctgttgg tcttgatgtt gtggaattct ttgcagcaag
     9301 aaatgctgaa atctctattg tggagatgat ggatcagatc ggacgtgacc tggatcctgt
     9361 tacaaagaat gacatgaagg accagatgaa gaaacatcat gtggcccagc ttacaaagac
     9421 agctcttcag gaagtaaaag acagctcttt ccttgtaaaa gatgcagaag gtgaacgtga
     9481 gcttccattt gactacggat tcgtatgtct tggtatgaga gctcagggac agcttttcgc
     9541 agagctttcc gatgcttttg tttctgatga tgttgagatc ctgaacatcg gagacagcaa
     9601 acgtgcaaga aggatcatcg acggaactct ggaaggaaga aatatcctta atacactgac
     9661 tcagatggga tacctttaat aaaaaccttt acaacaaaat acgaaagggg atattataat
     9721 ggctgaaaga attaccggac atactgaatt aatcggtctg atggcttacc cgatccgtca
     9781 ctccagctct cctgcaatgc agaatgaggc ttttgcaaaa ctcgggtatg actacgctta
     9841 ccttgctttc gaggttggcg cagatgagat tgaggatgca gtaaaagtaa tccgtactct
     9901 gaaaatgaga ggatccaatg tttccatgcc aaataaaact ctggttggaa aatacctgga
     9961 tgaactttct cctgcagcag aattatgcgg tgcagttaac acgatcgtaa atgacaacgg
    10021 tcatcttaca ggtcatatca ctgacggtat cggatttatg tctgccctga aagataatga
    10081 tattgatgtg atcggaaaga aaatgactat cgtcggtgca ggcggtgctg ccactgccat
    10141 cgagatccag gctgctttgg acggcgttgc cgagatcaca atctttaacc gcaaggatga
    10201 attctggaat cgtgcagtat ccacagtaga gaagatcaac gcaaagacat cctgccatgc
    10261 agttctttat gatctggcag atcttgataa actgaaagct gagatggatg acagttttat
    10321 ctttgtcaat gctacaggtg tgggaatgaa accactggaa agccagtccg ttgttccgga
    10381 caagtcttac ttccgtcctg agctgatcgt tattgatgtt ccttactctc ctctggaaac
    10441 aaagatgcgt tccatggcca aggaagttgg atgtaagaca atgaatggtc tgggaatgat
    10501 gttattccag ggttccgctg catttgagtt atggacaggt gaaccaatgc ctatcgaaca
    10561 tatgaaagag attcttcaca tctcctatga tgactgatac ctgatggtat cttcagtaaa
    10621 gatatctcat attgtgatgc agaacagatc atttcactga tctttctgca cataatattt
    10681 gatatatacc gcttttcggc gtactgcagg agatgtactg atatattact ccgcgcagaa
    10741 tgtacatatc ctgcagtttg cttcaaaaag ctgttgatca tgcggttatg ttacggttat
    10801 tcttataaca gttccataat aatccggaac tactataata caacagaaaa tatgaggata
    10861 aacagatgaa cacagttcag gtaaaaaaca ctgtgatcgg cgagggcaga cctaagatct
    10921 gcgttcccat cgtaggaaaa acaaaaacag acattctcga agaagccaaa aagatcacta
    10981 ctcttcctgt tgatgtagtt gagtggcgta tagactggtt tgatgatgtc tttgctactg
    11041 agaaagtatt agaaaccgct aaagagcttc aggaagtttt aaaagacatt cctgttctcc
    11101 ttacattccg tacttccaaa gaaggcggtg agaaagaaat ttctgtaaat gactatgctg
    11161 ctttaaatat tgcagctgct cagagcggtt atgtagattt aattgatgta gaagcattta
    11221 caggtgatga agttgttaag acaatcatca atgctgctca tgaggcaggt gtaaaggtaa
    11281 ttgcttccaa ccatgatttc tttaagactc cggagaagga ggagatcatc cgacgcctct
    11341 gcatgatgca ggagctgggt gctgatatcc ctaagattgc agtaatgcct acctgtaagc
    11401 aggatgttat cacactgctg tctgctactc tggaaatgtc tgagaaatat gcagaccgcc
    11461 cgatcattac catgtccatg gctggaacag gtgttgtcag ccgccttaca ggtgagacat
    11521 tcggctccgc tctcactttc ggtgctgctt ccaaagcttc tgctccggga caggtcggtg
    11581 tgcatgaatt aaaacaggtg ctggatatca ttcacagcag cctgtgatct gttgatgaat
    11641 gatgtgatat cggatgctat tcttgcctat agctgatatc actcatattc gtcaacagat
    11701 tgttacagaa tttgaattta ataattatga ctccttaaaa taataattga tgaaaaccaa
    11761 gaagaacagc cccgaatccc ggctgttctt cttggttttc gtttatatta ttttttctca
    11821 aagggattcc agttggacag gaagatattc agtccgaagc caactgccag tgcccatgca
    11881 gatgcccatg cggttccctg tgctgcgagg actgctgcca ttacgcctgc gatcatcttg
    11941 tctctgtcgc tcttgcagta atccatacca attctcgcac atacaaatgc ctggaacatc
    12001 agagtaatgg aagagcctac tccgaagatg ggacggaaga aacttactac aggaatgatc
    12061 agcacactta agaatgtggc cagtctgaaa gaagccatcc ctccgagaag ggacttcata
    12121 gctttctttc cttctttgta acgcatggat acggatacag tcattccaac ccataacggg
    12181 ccggaaagag gaggaaatgg tgcgatgatg gacaggatca ggtttctcag accgctgacc
    12241 agattggaac ggctggaatt gaaatcaata tactcatcat ctcttgcgtg acgtgcctct
    12301 gatacaagag tctctgtagt aacaaaatca ccaaatgcaa taacataaca caccagtgcc
    12361 agcggcaatg ctttgataaa catagatgca gaaggaatcc ctacgccgaa gatactcacc
    12421 tgatcaatga tatctttgaa ctgaggaatc ttgataaagg taccgatctc cagtcccggg
    12481 gcatccagtt cgccaaccag aagtcctact accattgcga taagataggg gaaaagattt
    12541 ccgtatctcg caacaagatc aagaaactta tttgtttttc tcttctcctg atatttgtca
    12601 gagaagctga tcaggatcag gagacctaca cctgcaacaa tagccagagg atatttgtgc
    12661 atatttccgt tctctcccag ctgtcctgcc ataactgtaa caggtgctgc aagaaggatt
    12721 ccgcctttga cagaattggg aactgcatga acaaatttat ccgccagtct ggtcacaccc
    12781 ataaagataa ataccagacc taccagcatc tgcagtgcga tcattgcctg gattctctcc
    12841 tctcccatag ggaagccttc cagaaatacg atggtcagag gcagtgtggg tgtgatccac
    12901 cccggtacta ccggatcgcc aagcagactg tggagcagat aaagaaatgt ctcaataatt
    12961 acacagctcc acgccagctc ataaggaagc cccagatatt gctccagata aggaacagct
    13021 gccagcgctg ttacacccag aatcaaaccc tgaatgaact caacagattc tatcttgtag
    13081 tgtataaaag gaagtcttat ctgaaatggt ccaaagggga tgtagggcag ttcattttct
    13141 cttctttgtg ttcttgtatg tgccatacaa tttctccttt tcagtgaatt gttagattac
    13201 ttctatattt cagcttgtat attctatctt tttgttaatt tttaaacaat ccagatttta
    13261 ataaaatcca atccgaccgg aaaaaatctg aaacttgtaa cgtccaaaca tatcttcagt
    13321 tggattggat tttaataatt ttttatttca aggcgtagaa aggaggcata gcggtagcta
    13381 cgacacccga caacaacgcg aaaataagaa atttagatgc gagattattc aggaaatcaa
    13441 cttgttggca cactgcctta ctgatttctg ttcttcttta caaagagggc gagcaggata
    13501 ccgacgatgg tcactgccat gttcagaaga agaatcattc tcggagcact gcttccgcca
    13561 actttggtaa tgtaccctgc aaggcttaag attgtgtagt tcgcgatgct ggatgcgatc
    13621 attaccagtg aggttgctgt tcccttattc tcagggaaga actctgctgt ggtggaaact
    13681 gccagctgga gaacaccgcc tgcacctgca tatccgatca caaaaccacc taccagacaa
    13741 ataaacggag cctggataaa gtagcagaga gccagcataa ttgtggagat tagcggatag
    13801 agaatcagga cgctaatctc tttcagacct tttttgataa aagctgctgt tgcaaggatg
    13861 gcagttgcag ttcccagggc atacagggac tggatctttg aaggatctgc cataccgtag
    13921 gaacgggcaa gttcctgatt acagttcagc cataacataa aggttgagga gctggtgaat
    13981 ccaatcagaa ttgcagcaat cgctgcaggg gaaatcttgt gtccggattt cttcttatca
    14041 gctttagcct gtactgcctt ctctctcgct ggaaagggga ggatcagaat tagaattccg
    14101 tcaatgagga ttgcaatacc tgctacgata aagattgtct tatatgacat atttgcagat
    14161 gctacgattc cgatcaggaa tggaagcagg aactggctca ggcagatgga aaattttgta
    14221 aacaggttag ctactgacgg gttgtttaca tagatttcca tacaggtggg gcttacgcag
    14281 gtatcgagga aagagtttgc aattccgccg atcactgcaa atgcatatcc cattgccatg
    14341 gatgtggaat tggccattcc aaagaagtat gctacataac agagcacacc gataattccg
    14401 ctcagttttc ttccatattt gtcagacaga ggaccggaga aaggaaggga aatcagacgt
    14461 cccagtccaa gggctgcaat tacagatacg accatactta catccagtgt gccatcagcc
    14521 aggggcttcg caccccaggc agctgcaaac tccggtttgt actgccccag gatagaagca
    14581 ccgattccat ggataaaata agtaaaatat gctgcaaggg aggtgaaaat gagcattttg
    14641 tttgttttct gtttcatttt ggtctcctag gttattatta cttgttttcg ttttcttcct
    14701 ggaatttctg atattcagct gttggcattt ccagtcctgt gtagagtttg taagctgcag
    14761 ctccctgcca taacagcatt ccttttccgc cgattgcaag cttgcagcct gcttctttgg
    14821 cttcttttac ca
//
