LOCUS       c00249_gnlPro..         9954 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJENKGDL_249.
ACCESSION   c00249_gnlPro..
VERSION     c00249_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:28:34
            Original ID  :: gnl|Prokka|CJENKGDL_249
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9954
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..9954
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6972:9916]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6973..9916
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..9954
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..9954
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             431..1279
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP_bind_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg249_1"
                     /sec_met_domain="ATP_bind_3 (E-value: 5.1e-08, bitscore:
                     21.6, seeds: 28, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENKLEHLKEYLKGLGSVAVAFSSGVDSTFLLKVAHDVLGDKAIA
                     ITAQSCSFPKRELNEAKAFCEKEGIQHVICQSEELEIEGFSKNPPNRCYLCKKELFEKI
                     GDIAKKNGIEYIAEGSNMDDNGDYRPGLIAVKELGVKSPLREAKLTKAEIREYSKELGL
                     PTWDKQSFACLSSRFVYGETISEEKLGMVEKAEQLLLDYGFHQVRVRIHGSLARIEIMP
                     EEFPKLLEKNVREDIAKKFKEYGFTYVTMDILGYRMGSMNETLGENDKTTADSSLKGKN
                     E"
     CDS             1276..3063
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M24"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg249_2"
                     /sec_met_domain="Peptidase_M24 (E-value: 6e-43, bitscore:
                     135.6, seeds: 437, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKERIAALRARMKETGIDAYLIPTDDFHGSEYVGEYFKCRKYI
                     TGFTGSAGTAVIMQDMAGLWTDGRYFIQAADQLEGTGITLFKMGEPEVPTVHEFLKKNL
                     TQGRCLGFDGRTVSAKEAAELEKMLDENGVSLSVDHDLAGDIWENRPVLSCEPVTELDI
                     KWAGESRADKCARIRKAMEKKGADLFVLTSLDDIAWLLNIRGGDIHCCPVVLSYLVMTK
                     TEIRLFANEKAFQTDVLEALEKDGVTLFPYDSIYEYVKTFKKDKKVLLCKKKVNSRLVS
                     NIPADTRILDEENLTLLPKATKNPVEVENERIAHIRDGVAVTKFIYWLKKNVGRIPITE
                     LSAAEKLYEFRSEQEDFIDNSFDPIIAYGKHAAIVHYFATPETDIPLEPSGFLLADTGG
                     HYKEGTTDITRTIVLGPTSEEEKKYFTAVLRGTLNLGAARFLHGCTGVNLDILARQPLW
                     EMGEDFKHGTGHGVGYLLNVHEGPNSFRWKIVPGGNAVLEEGMITSDEPGYYREDGFGI
                     RHENLMVCKKAEKTEYGQFMCFEFLTMVPFDLDGVVPELMSVRERNLLNDYHAQVYEKI
                     SPYLNEEEKEWLKDATRAI"
     CDS             complement(3151..4917)
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     286.4; E-value: 2.8e-87)"
                     /gene_kind="resistance"
                     /locus_tag="ctg249_3"
                     /transl_table=11
                     /translation="MSRSTIKDPAKSKSSETFFKVLRFIGRYRFLLILSIILAAVSVIL
                     QLYVPILFGNAIDQVIAQHQVNFEMMWHYLSRILVMVILSSAATWLMNVINNRMTYQTV
                     KDIRAKAIRHIQVLPLSYLDGHSTGDIISRIIADTDILSDGMLLGFTQLFSGIVTIIGT
                     LIFMFSKNFWITLMVIVLTPVSFLVAKFISSHTFQMFRKQSDARGRQTALIEEMIGNQK
                     VVQAFGYEEKSSERFAKVNEELQECSLKAVFYSSLTNPSTRFVNNIIYACVALVGAFII
                     PGGRLTVGGLSVLLSYANQYMKPFNDISSVVTELQNALACAGRIFDLLEEEPEVAEASE
                     TLKDVKGEVDIKNVCFHYDESKKLIEDFNLHVKPGMRVAIVGPTGCGKSTFINLLMRFY
                     DVNSGSISVDGKPIRDITRHSLRSSYGMVLQETWIKNGTVRDNISIGKPEATDTEIIEA
                     AKLTHSWEFIRRLPKGLDTMLNEDSLSQGQKQLLCITRVMLCLPPMLILDEATSSIDTR
                     TELQIQEAFERMMEGRTSFIVAHRLSTIRNADLILVMKDGSIIEQGTHDELIAKGGFYH
                     TLYNSQFAKVSE"
     CDS             complement(4914..6728)
                     /locus_tag="ctg249_4"
                     /transl_table=11
                     /translation="MRSLAVYLKNYKKESILAPFFKFLEVVFDLIVPIVIAQIIDVGIA
                     NHDNGYIVQRFSILILMAALGLASTITAQFFAAKASVGFATELRQAVYDHVQHLSYTEL
                     DTLGTDTLITRLTDDINQVQNGLNMGLRLLLRSPFIVLGSMVMAFTIDFKCALVFAVAI
                     PFLFLVVFVIMFLSIPLFKKVQGKLDTVTGLTRENLTGVRVIRAFCREKEAVAEFDTRN
                     QELTKLNLFVGKLSALLNPVTYVLINIATVILIQKAGVEVNLGGMQQGQVVALYNYMAQ
                     MIVELIKLASLIITLNKSAACAGRVADILKVKSTMDYPSSSTYSAQISKDLATATADAS
                     LSENAIVFDDVTFAYSKAGAPSLSHISFSVKKGQTVGIIGGTGSGKTTLVNLISRFYDA
                     SKGTVLLDGQNIENYTRSDLRSRIGVVPQKAALFKGSIRDNLKWGREDASDEDLWQALT
                     TAQGKEVVEGKPGQLDFMLEQNGKNLSGGQKQRLTIARALVKKPEILILDDSASALDFA
                     TDAALRKSLNRLDWKVTTFLVSQRSSSIQQADLILVLDNGTLAGKGTHAELLRTCDTYR
                     EIYFSQFPEERARYSSVSAGNIMKEVTV"
     CDS             6973..8244
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg249_5"
                     /sec_met_domain="HGD-D (E-value: 1.5e-56, bitscore: 181.1,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIIETFGHYVENLTDKKPQSACRLLKTGWEAQNLKFRYMQDKRL
                     MPADRHLANLMMDTMLWPLQKPEDSVIVSIFTPCEMMQEVGLHPYNVEGFSCYLSASKA
                     ERAFLQQAENQGIAETLCSYHKTFLGAAQKGLLPKPKCIVYTNLTCDANLLTFRTLADF
                     YQVPVFAIDVPWNQTTENVQYVADQLKDLKIFLEKNTGKTISEDRLKERLACSKRTLEN
                     YKKYQQMRADRYVPSDLVTPLYAGMTNNILLGTAEEEKYTQMLLEDIKKAQAAKGKHIY
                     WMHTIPFWSDAVRQELCFSEKAQIVGCELAETCEPDFDPENPFEAMAERMVYHSLNGSA
                     LRRIEAGIRHAKQAGADGAVWFGHWGCKHTLGAAQLAKKKFEEAGLPLLILDGDGCDRS
                     HGGEGQTSTRLGAFLEMLGGAENE"
     CDS             8237..9916
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg249_6"
                     /sec_met_domain="HGD-D (E-value: 8.1e-18, bitscore: 53.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 2.7e-66, bitscore:
                     212.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKIYYVCKYTPIELLESLGGECENFNHMPEGFDLADQVSHPNIC
                     GFGKTLLEGVMEGKIKELVLVSCCDTIRSAYDILLESGKLDFLYILDVLHCDSACSRER
                     MAVQLKGLAKAYAQYKGTEFDAGKFRAAFHAQEKITKSHIAVLGARMGQELFEMTSKAM
                     PLPVENDTCVHNRSVGNILPPEGASFDELMDWYAGEILGQIPCMRMMDPTGRKKLYNDP
                     SVAGIIYHTVKFCDFYSFEYAEIKNHTDVPLLKIESDYTIQSSGQLLTRLEAFAESIQP
                     ETLEQTIDGDTKGERKMGKGYFAGIDSGSTSTDVVILNKDHEIVTSIILPTGAGAAIGA
                     DRALAEALKEAGLQREDIDALVTTGYGRTAIKNGDKSITEITCHARGAHFLNPEVRTVI
                     DIGGQDSKVIRLDENGAVANFVMNDKCAAGTGRFLEMMARTMEMNLDQMSECGLEFKED
                     ITISSMCTVFAESEVVSLIAQNKATDDIVHGLNKAVAVKTAALTRRVGGEEKYMMTGGV
                     SKNKGLVKTLEEKLGTKLVITDKAQLSGALGAALFAADMADV"
ORIGIN
        1 tctgaaataa gtatctctgg gtgttattta taatatgggg tagtggttaa ttattatgtc
       61 atgtatgaat ggagaagaaa caaacggaga actgcttcag aaaaagaagt agacaaactg
      121 taaataaaga agttaagaga ggctgttact ttagaaacta tttaaagaag taatagaagt
      181 cggggaagcg ttagaaaaga tacaagaaac ataaatcaat attgttcgtt ctattttcag
      241 taacacattt cgcaatgcga aaaataagtt gctgaacagt cattgcctat attataatga
      301 agctatagca ccctgttaaa taatacattt gagaaagttc aactttcacg ctttgttgag
      361 ccagatcaat atacattatt tacgaggagt gctacaggta caataaaaaa cggacaagag
      421 gcagactgat atggaaaata aactggaaca tttaaaagaa tatctgaagg gacttggcag
      481 tgtagcagtt gctttctcaa gtggagtgga ttctacattc ttattaaaag tagctcatga
      541 tgtgctgggt gataaggcga ttgcgattac agctcaatcc tgttctttcc cgaaaagaga
      601 gctgaatgaa gcgaaggcat tctgcgagaa agaggggatt cagcatgtga tctgccagtc
      661 tgaggaattg gagattgaag gattttcaaa gaatcctccg aacagatgtt atttatgtaa
      721 aaaagaactg tttgagaaga ttggcgatat tgcaaaaaag aatgggattg aatatattgc
      781 agagggatca aatatggatg ataacggcga ttacagacca ggtctgatcg ccgtaaaaga
      841 acttggagtt aagagcccgc tgcgtgaggc gaagctgacg aaagcggaga tcagagaata
      901 ctcaaaggaa ctggggcttc cgacttggga caaacagtca tttgcctgtc tgtcctccag
      961 gtttgtctat ggagagacca tcagtgagga aaagcttgga atggttgaga aagcagagca
     1021 gcttttactt gactatggat tccatcaggt acgtgtccgt attcacggtt cacttgcaag
     1081 aattgagatc atgccggagg aatttccgaa acttctggaa aaaaatgtcc gagaggatat
     1141 tgcaaagaaa tttaaggagt atggattcac ttatgtgacc atggatattc tgggatatcg
     1201 tatgggaagt atgaacgaaa cacttggcga aaatgataaa acgactgcag atagcagcct
     1261 taagggtaaa aacgaatgac agtaaaagag agaatagcag cacttcgtgc acgcatgaaa
     1321 gaaacaggaa ttgatgcata tctgattcct acagatgatt ttcatggttc agaatatgta
     1381 ggtgaatatt tcaaatgcag aaaatatatc acaggattta ccggttctgc aggcactgcg
     1441 gtgatcatgc aggatatggc aggattatgg acggatggac gttattttat ccaggctgca
     1501 gatcagctgg agggaacagg aattacttta tttaaaatgg gtgaaccgga agttcccaca
     1561 gttcatgaat ttctgaaaaa aaatctgaca cagggaaggt gtctgggatt tgacggacgt
     1621 actgtcagtg caaaagaggc agcagaattg gagaaaatgc tggatgaaaa cggtgtgtct
     1681 ctcagtgttg atcacgatct ggcaggcgat atatgggaaa accgtccggt actttcctgt
     1741 gaaccggtta cagagctgga tataaaatgg gcgggagaat ccagagctga taaatgcgca
     1801 agaatccgca aagcaatgga gaagaagggt gcagatttat ttgtactgac ttctctggat
     1861 gatattgcct ggctgttaaa tatacgtggg ggagatatcc actgttgtcc ggtggttctt
     1921 tcttatcttg taatgacaaa aacagagatc agactttttg caaatgagaa agcctttcag
     1981 acagacgtac tggaagcgct ggaaaaagat ggtgtgaccc tttttcccta tgacagtatc
     2041 tatgagtatg tgaaaacatt taaaaaggac aaaaaagttc ttctctgcaa aaagaaagtc
     2101 aacagtcgtc tggttagcaa tattccggca gacacccgga ttctggatga agaaaatctt
     2161 acacttcttc ccaaggcaac gaagaatcct gttgaggtgg aaaatgaacg cattgcgcat
     2221 atcagagacg gagttgcagt tacaaagttc atatactggt taaagaagaa tgttggaagg
     2281 attccgatca cagaattaag tgcagcagaa aagctgtatg aattccgttc ggaacaggag
     2341 gatttcatag ataacagttt tgatccgatt attgcctatg gaaagcatgc tgctattgta
     2401 cattattttg caacacccga aacggatatt cctctggaac catccggctt tcttctggca
     2461 gatacaggag gacattataa agagggcact actgatatta cccggactat tgtcctggga
     2521 cccacttctg aggaagagaa aaagtacttc acagcagttt tgcggggaac tctgaatctg
     2581 ggagctgcca gatttcttca tggttgtacc ggtgtaaatc tggatattct ggcgagacag
     2641 ccactgtggg aaatgggaga ggattttaaa catggaaccg gtcatggagt aggatatctt
     2701 ctgaatgtcc atgaaggacc caatagcttc cgatggaaaa ttgttccggg tggaaatgca
     2761 gtgctggagg agggaatgat cacctctgat gaaccgggat attacagaga ggatggattt
     2821 ggaatccgtc atgaaaatct gatggtctgc aaaaaagctg aaaaaacaga gtatggtcag
     2881 tttatgtgct ttgaatttct gactatggta ccttttgatc tggatggagt ggtgccggaa
     2941 ctgatgagtg tccgggaacg taaccttctc aatgattacc atgcacaggt atatgagaag
     3001 atttctccgt atttgaacga agaagaaaaa gaatggctga aagatgctac ccgggcaatc
     3061 tgataaaaat aaaaaaacat tttacaaaat caaaaagagg aacagtcgtg atggacagct
     3121 gttccttttt gatttattat ctggtttgtt ttattcagaa acttttgcaa actggctgtt
     3181 atataaagta tggtaaaatc caccttttgc aatcagctca tcatgagtac cctgctcaat
     3241 gatacttccg tctttcataa caagaatcag atctgcattt cggatggttg aaagcctgtg
     3301 agctacgata aagcttgttc ttccctccat cattcgttca aacgcttcct gaatttgtaa
     3361 ttctgttcgt gtatcaatac tggaagtagc ttcatccagg atcagcatcg gaggcagaca
     3421 gagcataact cgtgtgatac acagcagctg tttctgtccc tggcttaagc tgtcttcgtt
     3481 gagcatggtg tccagtcctt taggaagcct ccggataaat tcccagctgt gggtaagctt
     3541 ggctgcttcg atgatttcag tatctgtagc ttccggtttt ccaatcgaga tattgtcgcg
     3601 gacagttccg tttttgatcc atgtttcctg aagcaccata ccatagctgc ttctgagaga
     3661 atggcgggta atgtctctga tcggtttgcc gtcaacggaa atagatccgg aatttacatc
     3721 atagaatctc atcagaaggt tgataaaggt tgacttaccg catccggtag gtcctacaat
     3781 ggcaacgcgc atacctggtt ttacatggag attaaagtcc tcaatcagtt tctttgattc
     3841 atcataatgg aagcacacat tcttaatatc tacttcaccc tttacatctt tcagtgtctc
     3901 agaagcctct gcaacttccg gttcctcctc cagcagatcg aagattctgc ctgcacaggc
     3961 aagagcattc tgaagttctg taacaacgga actgatatca ttgaatggtt tcatatactg
     4021 gttggcatag gagagaagta cggaaagtcc tccgactgtc agtctgcctc cagggataat
     4081 gaatgcaccc accagtgcaa cacaggcata aataatatta ttgacaaaac gggtggaagg
     4141 gtttgtcagg ctgctgtaaa aaacagcctt cagactgcat tcctgtaatt cttcgttaac
     4201 ctttgcaaag cgttcagaag atttttcctc atatccaaaa gcctgaacaa ccttctggtt
     4261 tccaatcatc tcttcgatga gagcagtctg acgtcctctg gcatcgcttt gcttccggaa
     4321 catctggaag gtatgggaag aaataaattt ggccaccaaa aagcttacgg gggtcaggac
     4381 aatgaccatc aatgtaatcc agaagttttt ggagaacatg aagatcagtg ttccgatgat
     4441 cgttacgatt ccggaaaaaa gctgggtaaa tccaagcagc ataccatcgg atagaatatc
     4501 tgtatctgcg ataatacggc tgataatatc tccggtactg tgtccgtcaa ggtaagagag
     4561 gggaagtacc tgaatgtgtc ggatggcttt ggcacggata tcctttactg tctggtaggt
     4621 catgcggtta ttgatcacat tcataagcca cgtggcagca gaagagagga tgaccattac
     4681 aaggatacgt gacaggtaat gccacatcat ttcgaagttt acttgatgtt gggcaatgac
     4741 ctgatcaatg gcatttccga ataggatcgg gacatacagc tgaaggataa cggaaactgc
     4801 tgccagtatg atactgagga tcagcagaaa acggtatctt ccgatgaaac gcagtacttt
     4861 aaaaaaagtt tcgctgcttt tgcttttagc aggatctttt attgttgatc tgctcataca
     4921 gtcacctcct tcattatatt acctgcagat acagaggagt atctggctct ttcttccgga
     4981 aactgagaga agtagatttc ccggtaagta tcacaggtac gcagcagttc agcatgagta
     5041 cccttacctg ccagagtacc gttatcaagg acaaggatca ggtctgcctg ctgaatgctg
     5101 gaggaacgct gggataccag aaatgtagtt actttccagt caagtctgtt gagagactta
     5161 cgcagtgctg catcagtggc aaagtccagg gcactggcac tgtcatccag gatcaggatt
     5221 tcaggttttt ttaccagggc acgggcaatg gtaagtcttt gtttctggcc gccggaaagg
     5281 tttttaccgt tctgttccag cataaaatca agctgtcccg gtttaccctc tactacctct
     5341 tttccctgtg ctgtggtaag tgcctgccac agatcctcgt cagaggcatc ttcccggccc
     5401 catttcagat tgtcccggat agagcctttg aaaagagctg ccttctgtgg aacaacgccg
     5461 attctggagc ggagatcact tctggtgtaa ttttcaatat tctgaccatc cagcagaaca
     5521 gttcctttgc tggcatcata gaatctggaa atcagattta ccagagtggt ctttccgctt
     5581 cctgtaccac cgataatacc tacggtctgt ccctttttta cagaaaaact gatatgggaa
     5641 agactggggg caccggcttt gctgtacgca aaggttacat catcgaatac gatggcattt
     5701 tcagaaagtg aagcatcagc agttgctgtt gcaaggtcct tcgatatctg agcagaatat
     5761 gtggaggaag aggggtaatc catagtagat ttcactttca ggatatctgc cacacgtcct
     5821 gcgcaggctg cagatttgtt cagggtgatg atcagggagg caagcttgat cagttccacg
     5881 atcatctgag ccatatagtt ataaagggca acaacctgtc cctgctgcat accgccaaga
     5941 tttacttcta ctcctgcttt ctggatcaga ataacagtag caatattgat cagtacgtaa
     6001 gtgaccggat ttaacaaagc ggaaagcttt cctacaaaga gatttaactt tgtcagctcc
     6061 tgattgcggg tatcaaattc tgcaactgcc tctttttcgc ggcagaatgc acggataacg
     6121 cggacgcctg taaggttttc tctggtcagt ccggttactg tgtccagttt tccctgtact
     6181 tttttaaaca gaggaatact gagaaacata atgacaaaga caaccagaaa cagaaacggg
     6241 atcgcaacag caaaaaccag ggcacattta aagtcaatgg taaatgccat gaccatggac
     6301 ccaagtacga taaacggact tcgaagaaga agacgaagcc ccatgttcag tccgttctgg
     6361 acctgattga tatcgtcggt aagtcttgtg atcagggtgt ctgttcccag tgtatccaac
     6421 tctgtatagg acagatgctg tacatggtca taaactgcct gtcttaattc tgtggcaaag
     6481 cccacgctgg ctttagcggc aaagaactga gctgtgatgg tactggcaag accaagagcc
     6541 gccattagta taagaataga aaatctctgg acaatgtatc cgttgtcgtg gtttgcaata
     6601 cctacatcaa tgatctgtgc aatgacgata ggcacgatca ggtcaaatac aacctccaga
     6661 aatttaaaaa atggcgccag gatgctttct tttttgtagt tttttaaata aactgccaat
     6721 gaacgcattt taaaaattcc ttcctttcgt aaaaaatctt tcctatatta tttcttcctt
     6781 tttttgaaaa ataatacatt caaaagtgta tcatttgaga cttttttgtc aagaagaatg
     6841 tgcaaaaaca gatgaacttt ggagaaaatt cagcttgact tcaaaaaaag atattactaa
     6901 aatattccgt agcgctattt gtacgctggc aactgataaa ttattattac cataatgagg
     6961 aagagacaga ctatggagat tattgagaca tttggtcatt atgtggaaaa tctgacggat
     7021 aaaaagcctc agtcagcctg ccggctgtta aaaaccggct gggaggcgca gaatctgaag
     7081 ttccgttaca tgcaggacaa gagactgatg cctgcagaca ggcatcttgc aaacctgatg
     7141 atggatacca tgctgtggcc ccttcagaaa ccggaagatt ctgttattgt aagtattttt
     7201 acaccctgcg aaatgatgca ggaggtggga ttacatccct ataatgtaga aggattttcc
     7261 tgctatcttt ctgcaagcaa agcagagagg gcgtttctgc agcaggcaga gaatcaggga
     7321 attgcagaga cactgtgcag ttatcacaag acatttcttg gtgcagcgca gaaaggactt
     7381 ctgccaaagc ctaaatgtat tgtttatacc aacctgacct gcgatgctaa cctgctcacc
     7441 ttccgtaccc tggcagattt ttaccaggta cctgtatttg ccattgatgt accatggaat
     7501 cagaccacag agaatgtaca gtatgtggca gatcagttaa aggatttaaa aatatttctg
     7561 gaaaaaaata caggaaaaac aatctctgag gacagattaa aggaacgtct tgcctgcagt
     7621 aagcggactc tggagaatta caaaaaatat cagcagatgc gtgcagacag atatgtgccc
     7681 tctgatctgg tcacaccctt gtatgcagga atgacaaaca atatccttct gggaacagca
     7741 gaagaagaga agtatacaca gatgcttctt gaagatatta agaaagcaca ggcagcgaaa
     7801 gggaagcaca tttactggat gcataccatt ccattctggt cggatgcagt gcgccaggag
     7861 ctttgcttca gtgagaaagc ccagatcgta ggatgtgaac ttgcagaaac ctgtgagccg
     7921 gattttgatc ctgagaaccc ctttgaagca atggcagaaa gaatggtata tcattcactg
     7981 aacggaagtg cccttagaag gattgaagcc ggtatccgcc atgcgaaaca ggcaggagca
     8041 gacggtgctg tgtggtttgg acattgggga tgtaaacata cgcttggtgc ggcacagctt
     8101 gcaaagaaga agttcgagga agccggtctg ccccttttga tcctggacgg tgacgggtgt
     8161 gatcgaagcc atggaggaga aggacagact tccaccaggc tgggagcttt tctggaaatg
     8221 ctgggaggtg ctgagaatga ataaaattta ctatgtctgt aaatataccc caattgaact
     8281 tctggaatct cttggcgggg aatgtgagaa ctttaatcat atgccggagg gatttgacct
     8341 ggccgatcaa gtttcacatc ccaatatctg cggttttgga aaaacacttc tggaaggagt
     8401 catggaggga aaaatcaagg aacttgtcct ggtgagctgc tgtgatacta tcaggagtgc
     8461 ctatgacatt ctgctggaaa gcggcaagct ggattttctc tatattttgg atgtgcttca
     8521 ctgtgacagt gcctgcagca gagagcgtat ggctgtacag ttaaaagggc tggcgaaggc
     8581 ttatgcacag tacaaaggca cagagtttga tgccggaaaa ttccgggctg ctttccatgc
     8641 acaggagaaa atcacaaagt cccatattgc agtgcttggc gccagaatgg ggcaggaatt
     8701 atttgaaatg accagcaagg ctatgcctct tcctgtagag aatgatacct gcgtgcataa
     8761 ccgttctgtg ggaaatatac ttccaccgga gggtgcttct tttgatgagc tgatggactg
     8821 gtatgcaggt gagattctgg ggcagattcc atgtatgcgt atgatggacc cgacaggtcg
     8881 taagaagctt tataatgatc cgtctgttgc ggggattatt tatcatacag tgaagttttg
     8941 tgatttttac agcttcgaat atgctgagat caagaaccat acagatgtac ctcttttaaa
     9001 aattgaatca gattatacta ttcagagcag cggtcagctt cttaccagac tggaagcttt
     9061 tgcagagagc attcagcctg aaacactgga gcagaccata gatggagaca caaaaggaga
     9121 gagaaaaatg ggaaaaggtt atttcgcagg gattgacagt ggttctacca gtacagatgt
     9181 ggtgatttta aataaagatc atgagattgt gaccagcatt atcctgccta caggagcagg
     9241 agctgctatc ggagcagacc gtgcccttgc agaggcattg aaggaggccg gattgcagag
     9301 agaagatatt gatgcgctgg ttactaccgg atacggacgt acagctatta aaaatggtga
     9361 taagagtatc acagagatca cctgtcatgc aagaggtgcg catttcctga atccggaagt
     9421 ccgtactgtt attgatattg gcggacagga cagcaaggtg atccgactgg atgagaacgg
     9481 tgcagttgca aactttgtta tgaatgacaa atgtgcggca ggaaccggac gatttctgga
     9541 aatgatggca cgtaccatgg aaatgaatct ggatcagatg agcgaatgtg ggctggaatt
     9601 caaagaagat attacaattt ccagtatgtg tacagtattt gcagaatcag aagttgtatc
     9661 cctgatcgcc cagaataagg caacagatga tattgttcat ggcctgaata aggcggttgc
     9721 cgtaaaaacc gcagctctta ccagacgtgt gggcggtgag gagaaatata tgatgaccgg
     9781 tggtgtttct aagaataagg gcctggtaaa gacactggaa gagaagcttg gaacaaagct
     9841 ggtaatcact gacaaagctc agctttccgg tgcacttggc gcagcactgt ttgcagctga
     9901 tatggctgat gtataaaaat tatttaaata tccagggatt ttacaaggtg gaaa
//
