LOCUS       c00260_gnlPro..        12770 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJENKGDL_260.
ACCESSION   c00260_gnlPro..
VERSION     c00260_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:28:34
            Original ID  :: gnl|Prokka|CJENKGDL_260
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12770
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12770
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[914:6522]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      915..6522
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12770
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             915..2633
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg260_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-49, bitscore:
                     157.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIKLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             2651..3160
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg260_2"
                     /sec_met_domain="ALS_ss_C (E-value: 5.2e-23, bitscore:
                     70.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3229..4485)
                     /locus_tag="ctg260_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             5248..5961
                     /locus_tag="ctg260_4"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAMKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTKANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     FNNQLPRLKVFLQTR"
     CDS             6163..6522
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg260_5"
                     /sec_met_domain="ALS_ss_C (E-value: 6e-23, bitscore: 70.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIATVSDDKTFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIK
                     VFNCSREDKAELFQIAETFKAKVIDYGKDSLLLEFVQTAIKNDAVVKLIKEEFHRIEVV
                     RGGSVGIESISMMER"
     CDS             6871..7509
                     /locus_tag="ctg260_6"
                     /transl_table=11
                     /translation="MNTTTTTTTTAATKRSSTLYMVELAMMIAIILLMSFTPLGYLRTP
                     GLSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFI
                     VCIVARVLEGWITGLIFAALYKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYI
                     QGIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             7634..8599
                     /locus_tag="ctg260_7"
                     /transl_table=11
                     /translation="MSLLKEISITDLSNLRIGHASDYNAQTGVTVLYFPLGAKVGCDIS
                     GGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVP
                     LVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQS
                     MKSGLGIAAVSVGNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRF
                     MTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASI
                     GDVSVDINMAGTLAAEVMAQAIQNAIHTSRIQDEEFLKYV"
     CDS             complement(9012..10196)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 76.1; E-value: 7.9e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg260_8"
                     /sec_met_domain="MFS_1 (E-value: 1.5e-24, bitscore: 76.1,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLL
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRICG
                     IANWKYMALVWALIPIANGIFFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMIMGIKMIGSLQKYD"
     CDS             complement(10510..11274)
                     /locus_tag="ctg260_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKEAGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             complement(11268..11465)
                     /locus_tag="ctg260_10"
                     /transl_table=11
                     /translation="MQIMKRLLIKNKRKLWLWFLLLVFLFLACRAAYITGSKAEQTRNN
                     EVEERQADSRSIPNEMEILC"
     CDS             complement(11601..12287)
                     /locus_tag="ctg260_11"
                     /transl_table=11
                     /translation="MKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGSGISAISS
                     VPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSELLDVNEA
                     WINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIKVKYSKIK
                     VSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFRFVNFTQH
                     CSLHVQ"
     CDS             complement(12456..12770)
                     /locus_tag="ctg260_12"
                     /transl_table=11
                     /translation="LKASAILAVTKSGSTAHKMSKHRPGCMLGACTSSERVLRQLKLSW
                     GVYPMLIKEEYSSEILCLRAIEAAQKHKLGKVGATMVFAGGVPLGIPGRTNLIRVCTVE
                     "
ORIGIN
        1 attctactct aatatcttgt aaaactcaac atgtgcttat atgattttat aatttatatt
       61 taactgttaa taaccttcca aacagctgta ttatttattt tttatatcag caatatagaa
      121 atctgtcaat tacattactg ttcactccgt tctcagtaac gtagccaaaa ttcattcagg
      181 aacataaatt ttacagcaat tatccaaaac ccggttgaca atttcctctc tataaatgta
      241 taatgtaacc caagaaaaca tttgtccacc ctattcggac aatgaatatc cctatatcag
      301 ccaaatgcca tgacagggag gagtacacaa ccccgggaag cacagagaga aagcggtcgg
      361 tgcgagcttt cgtgaacgaa ttgtggaagt agcccccgag cagtgaacca aaccgcatat
      421 ccagtcagat gatccataga tccggacaga catgccaagt agacttcaac gtcagttcca
      481 cgttacagga acacagtata tcagtactga caaagtgcag agccagactc tgaatacagg
      541 tggtaccgcg gaaacatttt cgccctgggc aaacaagccc agggcgtttt ttactatatt
      601 cagaattgtg ggagctgctt tacagcgttc tcagcagaat cagcgcagcg ccattctgcc
      661 cctgtatcag ccaatacaca gctcagaaat ttatttgttt ggtgtgcatt tgcaggagtc
      721 gtgtagatct tagtgcctgg aaatctgcgt tgttcagaaa aatctcactg tctgagcgca
      781 gcgagtttga gatttttctg aacgctttta gcagattttc agacacttag atctactagg
      841 ctccgaaacc gcacaccaaa caaataaatt tctgagcgtc cccatccaca tacacaaagg
      901 aggtttaccc aaatatgaaa caaatatccg gcaacaaact cttagtcaaa gccttaaaag
      961 aagaaggcgt agaatacctc ttcggctacc ccggagcctg taccatcgac atcagtgatg
     1021 aactctacaa acaggacgat gtcaaaatca tcctcccccg tcacgaacag gcccttgtcc
     1081 acgaagcaga cgcctacgcc agaaccaccg gcaaagtcgg cgtatgtctg gtaaccagcg
     1141 gtcccggagc aaccaacctt gtaacaggac ttgcaaccgc caactatgac agcgtacctc
     1201 ttgtatgctt caccggccag gtagcccgcc acctcatcgg caacgatgca tttcaggaag
     1261 tagacatcgt aggaatcacc agaagcatca ccaaatacgg tgttactgtc cgcagacgtg
     1321 aagacctggg acgtatcatc aaagaagcct tctacattgc ccgcaccggc cgtccgggac
     1381 ctgtccttat cgaccttcca aaggacgtaa tggcagaact cggcagcgct gaatatccta
     1441 aaaatgtaaa tatccgcgga tacaagccca acacagatgt ccacatcggc cagctcaaac
     1501 gtgccatcaa acttttaaat aaagcaaaac gtcccttatt cctggcaggc ggcggtgtag
     1561 taatctcccg cgcccatgaa attttccggg aagtagtgga aaagacaaaa gtaccggttg
     1621 tcacaaccgt aatgggaaaa ggctctatcc ccacagacca tccgctctat atcggaaacc
     1681 ttggcatgca tggtgcctat gcagcaaata tggcagtcag caactgcgat gtgctgttct
     1741 ccatcggaac cagattcaat gacagaatca ccggaaaact tcatgaattt gcaccacatg
     1801 cccagattat ccacattgat attgatacag catccatttc ccgaaacatt caggtggata
     1861 tccccattgt tgctgatgca aaagaggcta tcaccaaaat gaacgaatac gtccaggaat
     1921 gttcaacgga caagtggctt aacctgatca aaaactggaa agaagagcat ccgcttaaaa
     1981 tgcgtccaaa tgatctttta agtccgatgg atatcctgaa agagatcaac gaacaatttg
     2041 agaacagtat tatcgtaaca gatgtaggac agcatcagat gcttgtctcc cagtatgcgg
     2101 aaatcacaga gggcaaacag atgatcatgt ccggtggtct gggaacaatg ggctatggtc
     2161 ttccaggcgg catcggagcc aaaatcggaa atcccgacag acctgtcatc gttatctccg
     2221 gtgacggcgg tgtgcagatg aacattcagg agcttgcaac tgcagttctg gaggagcttc
     2281 cggttatcct gtgtatcttt aacaatgagt atcttggaat ggtacgccag tggcagaagc
     2341 ttttctacgg caaacgctat gctatgacca atctgcgcgc aggagcactt tcccgccgca
     2401 cagaaggcat ggaatatcca cagtacacac cggatttcat taaacttgca gaaagctaca
     2461 gggcaaaagg aatccgtgtc acaaagaaag aggaaattgc agcagccttc gaggaagcaa
     2521 aaaagaacac aaaggcacct acagtaattg aattcatcat tgaccctgag gaaatggttt
     2581 atcctatgat caaaccaggc ggaactctag aagatatgat tatggactgt tgatcaggag
     2641 gaaaattatt atggataaag gaatgaaaaa aagatggatt tctctctatg ttgagaacca
     2701 ggtaggtgtt ctgtccaaaa tctccggact tttctccgga aaaagctaca atctggacag
     2761 tcttactgta ggaaccaccg aggaccccac agtatctcga atgacgatcg caactgtcag
     2821 tgatgatgaa acttttgagc agatcaaaaa acagttgaac cgtatgatcg aggttattaa
     2881 ggttattgat ttcacagacg tatttgtccg catgaaagag attctgtata ttaaggtttt
     2941 taactgttcc aaagaagata aggttgaact gtttcagatt gccgaaacct tcaaggcaaa
     3001 ggtcattgac tatggcaaag acagcctgct cctggaattt gtccagacag caaccaagaa
     3061 tgacgcagta gtgaaactga tcaaggaaga atttcacaga attgaagtgg tacgtggagg
     3121 aagtgtagga atcgaatcta tcagtatgat ggaacgataa aactttttct gaaattttta
     3181 taaagggagg attgtcgcat tgttcttaat gctcagtcct ctctttactt acggttcttc
     3241 cgtcttttcg tttttcatct gtgctttcgc ttttcgccca atccgtgcat tgctgttcat
     3301 aatactggca cgggtgatct tatcatttcc aaatttcatc cggatctcat ccatagctgc
     3361 atccagcttt ctgtggcgtt ctttattttc tgtatcttca aacagagaca tctgttcata
     3421 agtgccatct gtaaggcctg tcagtgccac accaatcaga cgtagcggct gtcctttcca
     3481 gaattcttta aaaagtcttg tagcatttat ataaatttca tctgtaagat ctgtagcatt
     3541 ttccagcttt gtctggtgtg aacggtttct gaaatccaaa gtacggaaag tcacggaaat
     3601 acagttgcat ttcttatctt ttctgcgcat tctggttgcc agaacatcac actgctccaa
     3661 aagtatggga aacacctgct ctatggaagt aatatcatcg ttaaaagtag tttccacgct
     3721 gaaacctttt gcctcatcag gcactgcttt tacaggggaa tcatcgatac ctctggcata
     3781 ttgccatagc tgatgtcccg ttttttcccc aagccagtac tgcacattgg atgctctttc
     3841 tcttgccaga tcaccgatgg tacggattcc ctgattcaga agcttctgct cggaagcttt
     3901 tcccagaaac agcagattac ggataggaag aggccacatt ttctccggga tttcatccgg
     3961 gaacagagtg tgtactctgt ccggcttttg aaaatctgat gccatctttg ccaaaagctt
     4021 attggtagaa attcctacat ttactgtaaa tcccagctct ctgtgaatct tgcctttcag
     4081 ctcatgagca gcagctacag ggtcaggata gatcagagaa gtacctgtca tatccagaaa
     4141 tacctcatca atggaaaaag attccatcac aggtgcaaag gaagcacaga ttgctttaaa
     4201 tgcccgggaa catttatcgt ataattcaaa atcactggga acgatcacca gattgggaca
     4261 tttccgaaga gccatggcta ctggctcgcc ggtctggatc ccgtattttt ttgcagggat
     4321 agatttggca accacgatac ctgtccgttt ctttggatct cctcctacac aggaaggaat
     4381 ttctctgaga tccggcagcc cctggctcac ccttctggct gattcccagg aaagaaatgc
     4441 actgttgaca tcaatatgaa aaattaatcg ttccgtactt ttcactgttc ttcctccaat
     4501 atatgaattg cgctcttcat atctgatgat ttcattttac cctgatctgc tctccagggt
     4561 aagaacctcg tttgtccaaa aaagtgtctt tatttacatc atcttgtctg agctgttact
     4621 gtatttatat ttgtttgatt tcactctgct atcagagttt tgaacaacaa cgccgcactt
     4681 gccatacggc agtgcggcgt ctgtatttcg ctaccggtca cattgttccc ggtaactttt
     4741 tttacttaat tctgaggatt catttcctct cgatatatac ttatcgatta gtcataaagg
     4801 ttaggagcaa tttcttcgct gtccatattt gtggaatcat accagtatcc agttcagcct
     4861 ccagccattc ataagagaat tccgggaatg tctgatgttt gaaatttttc catgttactc
     4921 ctttctcatg aagtaactgt ctacacataa gcaaacagtg ctatcgctgt cattgatcag
     4981 caataagccc ccgtgttttc atatagttcc attatacctt ctcattttcc cgaagtcaac
     5041 ataatttaac atgtatcagc cgtttatttg tgttgctttt tatttgattt ttgttgtatt
     5101 tcagttgttt ttattttgtt tcctcattga catttaaatc ctcatctgtc atacttgaat
     5161 ataacgaatg taccatcaaa cagcagcttt gcatcttccg taaggctctt atcatatata
     5221 gaaaccgctc tggaaaggag acaaacaatg tatctttctg acatccacac acattctatc
     5281 gccagcggtc acggaaccac ctgtaccatc tctgacatgg caaaagcagc cagcaaaaaa
     5341 ggactgaaac tccttgggat ttctgaccac ggcccgggaa ctctggcttc cggaacttct
     5401 tcttatttca gaagccttcc tttttatccc agaaaaagat tcggcataga tattctttac
     5461 ggagttgaac taaacatcct ggacagtgca ggacatacag atctgtcaga tgaactgctg
     5521 aacaacctgg attacgctat catcagtatg catcggcaga actaccgttc aggctctgta
     5581 tctcagaata cagaagctta catcaatgca atgaaacatc ctgctgtaaa aatactcggc
     5641 cactgcgacg atacacattt ccctgtagat tatgaaacgc tggcaagagc agctttacgg
     5701 gaaaatgtta tttttgaaat aaacgaagct tccctcgcac ccggaggata tcggggagac
     5761 acaaaagcca atgccgccag aatcctgtat ctctgtcaga aatatcagct tcctgttatt
     5821 ttgtccagcg acagccacgg aaaagaacat gttggagatt tcacctatgc cgaagaattc
     5881 gttcaccagc tcatgtttcc ggaaactctt atctttaaca accaacttcc cagattaaaa
     5941 gttttccttc agacacgtta aaagaatgtt cctcaaaggg acattctttt attttatgca
     6001 ttgttttttg cattgtgtta ttttgtttat tttctataat ttcttgtcaa aaaagacgac
     6061 attttagtac attttaatta acaaaactca cttaaccatt tacatatctc gtgatagatc
     6121 agtcttactg taggaaccac cgaggatcct acagtatccc gaatgactat cgcaacagtc
     6181 agcgatgata aaacctttga acagatcaaa aaacaattaa accgcatgat cgaggttatc
     6241 aaggtaatcg acttcacaga tgtatttgtc agaatgaaag aaattctcta catcaaggtt
     6301 ttcaactgct ccagggaaga taaagcagag ctgtttcaaa ttgcagaaac cttcaaggca
     6361 aaagtcattg actacggcaa agacagcctg cttctggaat ttgtccagac agccatcaag
     6421 aatgatgcag ttgtcaaact gatcaaggaa gaattccaca gaatcgaagt agtacgtggt
     6481 ggaagtgtgg gaattgaatc catcagcatg atggaacgct aaatctcata atcaatattt
     6541 tttgcagaat atagaaacgt ctctatatcc tgtatttatt ttcaaacata ctataaaata
     6601 ttgcagtttt taatcaaatg tgttattgtt tacgagagcg ttattcgaaa gaaaatgcat
     6661 ctgatttcca catctgacag tctggtggat aaagtcatcc acttcacagt ctggttaaat
     6721 ttgtgaggcg acctgtaagg cgtctacaca ccggaaattt ttcttttgtt ctgatgcata
     6781 tttttcataa cgcctgatcc ccatactcta aactgtctga aaagcagggg acgcattgcg
     6841 ccgttttatc agaccaaaag gagaattcat atgaacacaa caacaaccac tacaacaacg
     6901 gctgcaacaa aaagaagcag cactctttac atggtagagc tggctatgat gatcgccatt
     6961 attctgctca tgtcctttac cccgctgggc taccttcgta ctcccggctt atccatcact
     7021 cttctcacca tcccggtagc tgtaggagct atcatcctcg gaccgaaagg tggtgctgta
     7081 tgcggacttg ctttcggtgc aaccagcttc tatatggctg ttacaggaag ttcagctttc
     7141 gctgctgcac tttttaacat taatccattt ggcactttta ttgtatgtat cgtggcacgt
     7201 gtgctggaag gatggatcac aggacttatt ttcgcagcat tatataaatc accggcgaag
     7261 aaattttcct attacgttgc ttcactggca tgcccgttac tgaatacttt cttcttcatg
     7321 ggctttttat gtctcttctt ctacaacaca gattacattc agggtattgt ttccagtctt
     7381 ggagtaagca atcctgttgt cttcgttgct gcttttgtgg gcgttcaggg actgatcgaa
     7441 gcgggcttct gctttgtagt gggaagcatc gtttccaagg cactttctgt ggcactgaaa
     7501 cgtgcataat ctttaaaaga acagccgttt accaaacaac cctgactaca ttgtcactgt
     7561 agtcaggatt tttttatccg gcacatttaa agcaggaacc ctacctgatt cggttaatac
     7621 aaaggagatt tttatgtcat tattaaaaga gatttctatt acagatcttt caaatttacg
     7681 catcggtcat gcttccgatt ataatgccca gaccggggta accgttcttt acttcccact
     7741 gggtgcaaaa gttggctgtg atatcagcgg tggcggtcct gcttccaggg aaactcctct
     7801 cacctctcct gtcactgccg acaatcccat caatgctatt gtcttgtccg gaggttctgc
     7861 ctatggactg gctgctgctg acggtgtgat gaactatctg gaatcacaaa atatcggtta
     7921 taacaccggt gcagccctgg ttcctcttgt atgccagtcc tgtatctatg acctctctta
     7981 cggagatcct aaaatacgtc caactgcaaa aatgggcgaa gaagcctgcc gtcaggcatt
     8041 tgcaggaaca gataccagaa ccggaaatat cggtgcaggt accggtgcaa ctgtgggaaa
     8101 actttacggt atgaaacaat ccatgaagtc aggtcttggt attgccgctg tatcagtggg
     8161 aaatttccag atggccgcaa ttgtcgttgt caatgcactg ggagatatct ttagtccaca
     8221 aaatggtcag aaaatcgcag ggctgaaaac gcctgacaga agcgggtttc tggatagtgt
     8281 ccacgaatta taccgcttta tgacacctca tgaccagttt accggcaata ccaccatcgg
     8341 ggctgtgatc accaatgggg cattttcaaa ggctgaactg aataaaattg cctctatgac
     8401 ccgctgtgcc tatgccagat gcatcaatcc tgtagcaact atggctgacg gcgattccat
     8461 ctatgctgcc agcattggcg atgtttctgt agatatcaat atggcaggaa ctctcgccgc
     8521 agaagtcatg gctcaggcta tccaaaatgc catccatact tcccggatcc aggatgaaga
     8581 atttttgaaa tatgtataac agtccgctat aaaagcgcag agaaaaagta tcatctctgc
     8641 gcttttattc ttcctgtctg tcttcatttt tcatctgtgc tctggttttt ctccaagcca
     8701 gagctgtaca tttgcttccc gttcccttgc cagatcacca atagtacgga ttccctgatt
     8761 cagaagcttc tgctcggagg cttttcccag aaataacagg ttacggacag gaagtggcca
     8821 cattttctcc ggtatttcgt ccgggaacag cgtgtgtact ctgtccgttt ctttggatct
     8881 cctcccacac aggagggaat ctccctgaga tccggcagcc cctggcttac ccttctggct
     8941 gactcccagg aaagaaatgc gctgtttaca tcaatatgaa aaattaatcg ttccatactt
     9001 tttaatatat ctcaatcata tttttgcaga cttccaatca tcttaatccc cattatcatc
     9061 aacacaggga aaatcagtgc cgcaaagatt ccaagtttca gattatcatt cagtgctcct
     9121 gaaatcatcc ccacataggt tggtccggat gagcatccca catctccagc aagggcaagg
     9181 agggcaaaca gggctgttcc gccacgcttt actgaggcag ccgccatgct gaaggttccc
     9241 ggccacataa tacctacaga cagaccgcaa accgcacatc caaggattcc caacgcaggt
     9301 accgggataa atgcgatcat cagataggaa accatgcaca gaactgcact gtattgcata
     9361 aagcgttcca gattgatttt atctccaaat ttcccataaa atgcccttga gcttcccata
     9421 agaattgcaa acgccatggg acctgccaga tccccgatag ttttattgat tccaaagctt
     9481 ttctcagcca gagtagaagc ccactggctt accgcctgct cactggctcc tgcacagagc
     9541 atcattaaca tcagaaccca gaagattttt ttcttaaaaa gctctcccat agtcagcccc
     9601 ttttcaccct catccagcag tggagcaatg ggaactctgg taaaaaagat tccatttgca
     9661 atgggaatca atgcccacac cagcgccata tatttccagt ttgcaatccc gcaaatacga
     9721 aagaataatg tagaaagaag taccactccc acatgtcccc aacagtaaaa ggaatgaagg
     9781 agactcattg ctttttcctt attatctgta gggcaggctt ccaccacagg acttaccagc
     9841 acctccagca atccgcctcc gatggcatag atcataactg caatgagaag tcccacaaac
     9901 ggatctccca ggcactccgg caatactgtg agcaaaatca gacctgcagc cgccattgca
     9961 tgtgccagga tcatagatgc acgataacct attctgtcca caaatccaat cgatgccaga
    10021 tctaccagca actggattcc gaaattaaaa gtaaccagaa gtgtgatttt ctgcagcgaa
    10081 atcccgtaac tgccctgaaa tgtcagaaac agcagaggaa cgaaattgtt cacaatggcc
    10141 tgcactacat atccgataaa acaggcctgc actgttctgt tgtaatttgt tttcatccga
    10201 tgttatatcc tccaatctga aatttattaa gctgacatca ttcagacatt gatccaccaa
    10261 acttctatat ctccacagtt ctaatagatt tctatccgtc aataatgaca gtgtatcaca
    10321 gattctctcc tttttctttc attatctttt gaaaatccca taaattttta tattattttg
    10381 actttttccc tataacaatt ctataaaatc ccaaaagtaa tacccccatc cgattccaaa
    10441 tatttcccgc aaaaaaagat gtgcaccata ccatttctga caccatacac atctcaaaat
    10501 aaacacttct tatcttctgt actctgcagt caggtcttta ataacctctc ctgcaataat
    10561 cagcccggcg acagacggca caaacgccac actgcccgga atatctctgc gctccgtaca
    10621 cttatgcgca gcacccggag gacaaataca atgcgacctg cagctgatcg ccatatcttc
    10681 aattggtctg atcggctgtt cctctgaata aacaaccttc agtttcttca caccacgctt
    10741 cttcagctct ctacgcataa ccttcgccag cggacacacc ttcgtcttat agatatctgc
    10801 cacccgaaat gcactggcat ccagcttatt tcctgcaccc atactgctga taacaggagt
    10861 ccctgcctcc tttgcacgca tgatcagttc aatcttcgca gtcactgtgt ccacagcatc
    10921 taccacataa tcatactcac taaaatcgaa atcagcagca ttctccggaa gataaaaaca
    10981 gttatggatt ctcacatctg ctttcggatt aatgtccagg atcctgtccc gcatcacctc
    11041 tgttttatat tgaccaacag ttttcctggt ggcaataatc tgtctgttaa gattcgtcag
    11101 gcatactttg tcatcatcga tcagatcaaa ggtccccaca ccgcttctga ccaatgcttc
    11161 acatacatat cctccaaccc ctccgattcc aaacactgcc acgcgggagt tctccagttt
    11221 attcattgct tcttttccca gaagaagctc tgttcttgaa aattgattca acataatatc
    11281 tccatttcat tcggtattga ccgactatct gcctgccttt cttctacttc attatttctg
    11341 gtctgttctg ctttgctgcc tgtaatgtaa gcagctctgc atgccagaaa caaaaaaaca
    11401 aggagcagaa accaaagcca gagctttctt ttgtttttta tgagcaaccg tttcataatc
    11461 tgcatcacta ttccttaata tattattttc agataccaga gttgcaacat acttccatca
    11521 cagatttctt atgatatctt tacttctata atgcgtcaag tatatcatag aaagaaaaat
    11581 cctgcaatga agaaactctg ttactgtaca tgaagtgaac agtgctgagt gaaattcaca
    11641 aaccggaagt gcttatccat ctcatcacca atcaatccaa ttacttttcc catggtaaat
    11701 gccgccatca ctgttccgat tcccagtccg ttgatatgcc ccaggatcag ccctgtcata
    11761 caggcagtaa tcatcagaca gatcacatca aaagaaacct tgatcttaga atatttcacc
    11821 tttataatct ctgacagttc acgaggaaac agatctgtag gaataatcgg cagaccgcat
    11881 ctgttagaaa gtgcgatccc tatacagatc agcagataac tgatcacaaa atataacact
    11941 ctgagtggaa ttgtctttgg caggatattg atccatgcct cattaacatc caaaagctca
    12001 ctgaatgcaa atccaaccag aaaactgcac agataagcag gtacaaattt ttttctcagt
    12061 atcatcagac ttaagatcag aagtgcctga aaaatataag tccatgttcc cagtgtaatt
    12121 accggaaata ctttttcaaa tgcataagga acactggata tggcagatat tcctgaacca
    12181 gaatacagca tcagaataac agcaagactg ttgatcatga ctgctatcac caatgccagc
    12241 tctcctctga aaatatgtct cgaatcttct tcctcatttg ttttcataac aattctctcc
    12301 tctaacacaa gcaagggact gctgtcagaa aatattttct gtcatacttt tctgacggca
    12361 gacccctgtg tcttttacat cttatatttt ctgaaaatac tattttttat cgaatcaggc
    12421 aagtttccca cttcaactac tgatattttc ctgacttact caaccgtgca gacgcggatc
    12481 aggtttgttc ttcccggaat tccaagcggt acaccaccgg caaataccat agtggcacca
    12541 acttttccaa gtttatgctt ctgtgctgcc tcgattgctc tcaggcaaag gatctcagaa
    12601 ctgtattctt ctttgatcag catcgggtaa acaccccagg acagcttcag ctggcgaagg
    12661 actctctcag agcttgtaca tgcaccgagc atacatcctg gtctgtgttt ggacatctta
    12721 tgagctgtac ttccagattt tgtcactgca aggattgcac tggccttcag
//
