LOCUS       gnlProkkaFPNDBBIJ_46   13583 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FPNDBBIJ_46.
ACCESSION   gnlProkkaFPNDBBIJ_46
VERSION     gnlProkkaFPNDBBIJ_46
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:34:09
            Original ID  :: gnl|Prokka|FPNDBBIJ_46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13583
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13583
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1994:3583]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1995..3583
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13583
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13583
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             16..1521
                     /locus_tag="ctg46_1"
                     /transl_table=11
                     /translation="MSNNIRIRKKKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDGDNVDKTEGSGKTDPTENADPTETPETSSE
                     KPAADENADTDNKEDKESKSDQDNKTDTDNEESKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGADDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSMNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVVVFIKKRKK"
     CDS             1571..1921
                     /locus_tag="ctg46_2"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSIMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             1995..2135
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_3"
                     /sec_met_domain="TIGR03973 (E-value: 6.4e-28, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 8.1e-28, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             2216..3583
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.1e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.1e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.8e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 4.7e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             3695..6103
                     /locus_tag="ctg46_5"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             6185..7897
                     /locus_tag="ctg46_6"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDIISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             8045..8569
                     /locus_tag="ctg46_7"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             8607..10937
                     /locus_tag="ctg46_8"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             11002..11631
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163.1; E-value: 9.6e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_9"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             11624..13138
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_10"
                     /sec_met_domain="PF04055 (E-value: 1.1e-24, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFKNRDFEHDVYELIKAFYPEAEIHTLYENGEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 atatagaggt gcgatatgtc caataatata agaataagaa aaaagaaatt aaaaggaacg
       61 ggtatttttg cggcagcggc tttaacagcg gctttgattg caggaaataa tataccgggt
      121 gtaacaagac aggtcagtgc ggctgagtca caggagaata ctgtgtcttc tctgattccg
      181 gacaacatca cgcttgataa gccagtagaa cttgcggatg tagaacttcc ggcaacggaa
      241 tatggaactt ttgaatgggc agatggaagt ttcgttcctg cacagcgtgt acagagctgt
      301 gaggtacttc ttataccggc agaagggcag gatttaagcc atgtggatgg atgggatccg
      361 gagagcggcg cggttgtcgg ttacatcaat gtaatagtga acagtattac ggatggtgat
      421 aatgttgata agacagaagg ctcaggtaaa acagatccaa cagaaaatgc agatccaaca
      481 gaaacgcctg aaacttcgtc agaaaaacct gccgcagatg aaaacgctga tacagacaat
      541 aaagaagata aggaaagtaa atcagatcag gataataaaa ctgatacaga caatgaagag
      601 agtaagattg aagaagataa aacagataat aaaaacaaca aagataataa cagcaatgca
      661 gataagacgg ataaagatac agaaactacc ggtaagctgg aacctgcaga tgatatgaca
      721 caggataaag aagatacgaa gaaagatgat gaagatggcg cagatgataa tatctttgat
      781 aatcctgttc tgccggacga taaggatgac cgtcctacag atgcagagga ttctctttct
      841 gatgaagaaa aagaagagag ggccgcactt aatcatacct gcgacggtat tacagtaagc
      901 ggagttaatc ttccatggta tgtacagttc agagtttcaa gcggtgacag ctatcagttt
      961 accaatgaat cagatgcaat gattttccag tcttatgaat ttgaactctg ggatcttaag
     1021 aataatacag aatatgagat ccctaatgga gattatatca gtgtcactgt gccggtaaaa
     1081 tccggatatc agtatactat cgaacatctc ctggacaacg gggcaactga gacgattatt
     1141 ccgagtgtag agaatggtat tatggtattc agcacacatt ctttcagtcc atttggaatt
     1201 gcaggaagca gacaattagt aggacctgat gcggggaatg atacggacga cacagatgcg
     1261 gtaactcctg caccggcttc ctccgacagt cagagctctg attccggaaa gaacaataca
     1321 gtatctatga atgacagttc tgacagcaat aatggttctt cttctgatca gaatgataat
     1381 tcaacggaaa ataaagctgt gaaaaataac aatacagtaa ataccggaga tacaacatca
     1441 attatgccgt ttgtgatact gtttgtggca gctgcagtga tcgccggtgt ggttgtattt
     1501 ataaaaaaga gaaagaaata aaagaataac actgattcct cccccatata gtttaacagg
     1561 aggggaagca atgaaagtca gagcaatttt gaaatcacta ttatttgcat atgcattaac
     1621 aggagtggca ttactgcttt tggccctggt actgtttgct tttgatctgg gagaaacagc
     1681 tgtagatgcg ggtattatta taatttatgt acttgcatgt ttcatgggag gctttatggc
     1741 cggcaaaatt gtgcgtaaag acaaatatct gtggggtgtt atcacaggtc tggcttacta
     1801 tgtattactg ttgactgtct ctattatggc aaaaggcggc tgggatatga gtgcagcgca
     1861 tgcagttaca acatttttta tgtgcacagg cggtggaaca ctgggtggaa tgctgtcgta
     1921 aaaaaaagct tttaaaatga aaagatatat gatatactat gccaagaata taattacata
     1981 aggaggatag agttatggaa catatcaaaa ccctgaatac aaagaattta cagaacactg
     2041 taaaaaaagg tggatgtggc gagtgccaga cttcctgcca gtccgcatgt aaaacttcct
     2101 gtacagtagg aaaccagagc tgcgagcaga aataagatca gctatggaga aatgagataa
     2161 gcagcggaac ttttattccg ctgcttatct tacgcttaga aaggatttta gtaaaatgag
     2221 tctgattcac cgttataaaa gcaatggctt taatattgta ctggatatca acagtggatg
     2281 catccatctg gtagatgagg ttacatatga ggttcttcca tatctggaag agggccttgg
     2341 cacagaagct attgcagaga aactggaaaa caaatataac agagaagata ttgagacatc
     2401 tgtaagagaa tgtaataagc tgaaagaaga tggaatgctt tttacaaaag atgtttatga
     2461 gaatgtaatt gaagaatttt caaataaccg gcagaccgtt gtaaaagcat tgtgcctgca
     2521 cattgctcat gactgcaatc tggcctgccg ttattgtttt gccgaagaag gcgaatatca
     2581 tggcagaaga gctcttatgt cctatgaagt cggcaaaaaa gctcttgatt tcctgatcgc
     2641 gaactccggt tccagaaaaa acctggaagt agatttcttt ggcggcgagc cgctgatgaa
     2701 ctggcaggtt gtaaaagatc tggtaaaata tggcagagag caggaaaagc ttcacaataa
     2761 gaaattccgt ttcactttaa caacaaacgg agttcttctg aatgatgaag taatggaatt
     2821 ctgcaataaa gagatgggca acgttgtact gagtgtggac ggacgtaagg aagtacatga
     2881 ttacatgcgt ccattcagaa aaggtgcagg aagctatgac ctgatcatgc cgaagttcca
     2941 gaagtttgca gaatccagaa atcaggacaa gtattatgta agaggtactt ttacccacca
     3001 taatcttgat ttctccaagg atgtgcttca tctggcagat cttggattca aacagatttc
     3061 tgtagagcct gtagttgcgg ctgatacgga ggaatatgcg atccgcgagg aggatatccc
     3121 ccagatcatg gaagagtatg atactcttgc aaaagaaatg attaaaagag agaaagaggg
     3181 aaaaggattt aacttcttcc attttatgat cgaccttaca ggtggccctt gtgtatacaa
     3241 gagactgtca ggctgcggtt caggaacaga gtacctggct gtaacaccct ggggtgattt
     3301 ttacccatgt caccagtttg ttggtgaaga acagtatctc atgggaaatg tagacgaagg
     3361 catcacaaag ccggaaatcc agaaggaatt cggcggatgc aacgtttaca caaagaaaga
     3421 ctgcaaagac tgcttcgcac gtttctactg tagtggcgga tgtgcggcaa atgcattcca
     3481 tttccaggga gatatcaaag gcaattatga aatcggatgc gaactccaga gaaaacgtgt
     3541 ggagtgcgcc atcatgataa aagccgcact ggcatgtgat tagtgggcag taatctgtct
     3601 gactgatacc gccgtcggct gttatcataa cagaaaatgg ctggcaggcg gatgaacatg
     3661 accgcggaca aaaaatcaag aagggaaaag aactatgaag aaaagtaaag gaatcgtagt
     3721 gctgcttctg acactgatcc tgactgtgtt cttttgcttt actgcagccg taggtatcgg
     3781 tcctaccgga accggtgcag caaaacatat caacacgggt cttgatcttg ccggtggtgt
     3841 cagcattacc taccaggcta aggagagcaa tccgacaagc gaagagatgt cagatacgat
     3901 ctacaagctt cagaagcgtg tagagcagta cagtactgag gctcaggtat accaggaagg
     3961 atcagaccgt attacagttg aaattcctgg tgttacagat gcagatacta ttttgaatga
     4021 tctgggtaaa ccaggttccc tgtatttcat cacaaaagaa gatgctgacg gaaaccagaa
     4081 ctttactaca ggacaggatg gatatgttct ctccagaact atggatgaga tcaaggaatc
     4141 cggaagtgtt gttctggaag gttctgatgt agcagatgcc cagggtggtg cgatccagaa
     4201 tcagaacaca agtgcaaagg aatatgtggt aagtcttact cttacttctg atggagaaaa
     4261 cagtggtaaa acaaaatttg cagaagctac aaagaataat gtaggcaagc agatcgctat
     4321 cgtctatgac aataacatta tcagtgctcc gaatgtaaat gaagagattt ccggcggaaa
     4381 agcacagatc agcggaatgt ctgacctgga agaagcacag aaccttgctt cttatatccg
     4441 tatcggttct ctgggactgg aactggaaga acttcgttcc agtgttgtag ctgcacagct
     4501 tggtgaagaa gcaatctcta caagtgttct tgcaggtgcg atcggtctga tcatcgttat
     4561 tatctttatg atcattgcat accgcgtacc tggtgtagtt gcaggtatcg cactgattct
     4621 ttatacatca ttaatgctga tcacgctgaa tgcctttgat attactctta ctcttccggg
     4681 tattgcgggt attattcttg gtatcggtat ggcggtggat gccaatgtta ttatttatgc
     4741 ccgaatcaga gaggaaattg gtgcaggagt ttcagtaagg aattctatta agtccggttt
     4801 cagcaaagct ttctctgcaa tctttgatgg aaatattaca acactgatcg cagcctttgt
     4861 gctgatgtgg cttggttcag gtactgttaa gggatttgct tatacacttg cccttggtat
     4921 cgtgatctcc atgtttacag cactggttgt atccagactg attgtaaatg cactttatgc
     4981 agttggtgta cgtgatccga aattctacgg atctgcaaaa gaacgtaagg cagttgattt
     5041 ccttggaaag aagaaagtat tttttgctat ttccattatc ctgatcctct gcggtccggc
     5101 agcgatgttt gctaattcgc atgcaggaaa caaagcgtta aattacagcc ttgagttctc
     5161 aggcggtact tctacgactg ttacatttaa tgaagatatg gatattaaga ccattgattc
     5221 tgaagtaact cctgttgtag aagaggtgac aggagataaa aatgttcagc ctacaaaggt
     5281 agtcggaaca aatcaggttg tgatcaagac acgttctctg aatcagagcg aacgtgaagc
     5341 tctgcagagt gcactggttg agaaatttgg tgtagatgac agcacgattt ccacagaaag
     5401 tatttcttct acagtaagta gtgaaatgcg tcgtgatgcg atcgtagccg ttatagtagc
     5461 tacaatctgt atgcttcttt atatctggtt cagatttaaa gacatccgtt ttgcaagcag
     5521 tgcggtattg gcgcttctgc atgatgttct ggttgtactt gcattctatg ctattgccag
     5581 agtatctgtc ggtaatacat ttattgcctg catgcttaca atcgtaggtt attctatcaa
     5641 tgctacaatc gttatttttg accgtatacg tgagaacctt cacagtggtt ccagagaaaa
     5701 actggcagaa attgtaaaca caagtatcac tcagactctt acaagaagta tttatacctc
     5761 ttttacaact tttgttatgg tagctgttct ttatatcatg ggtgtttctt ctatccgtga
     5821 atttgcagca cctctgatgg ttggtgttct tgtcggtgca tattcttctg tatgtattac
     5881 aggtgcgttg tggtatgtga tgaaaaagaa atttgcagga aaaggacagc cggcaattgc
     5941 tgcagcttcc gcatctgcaa agtcctcttc aaagccgaag aaagcacgtg atgtatcaca
     6001 gaaagatccg actcagccaa agaagaaaaa cagaaaaaga gtagctgaac gtctggctgc
     6061 cgaagaagca gctaaaaaac agcagaatga tgatgctgaa taaaacaata attgtctgaa
     6121 aaacaggcag acagaaatat cccggggtaa aactccggga tatttttatg aggagagaaa
     6181 atatatggag aaatgggtaa tagcagcaaa aagagcagat tttaaccaga tcggtcaaca
     6241 gtttcatatt gatccggtga ttgcgagact gatcaggaac agagatgtga tcggagaaga
     6301 taagataaga gagtatctgt caggaacagt acaagagctt ccttctccct ggctgatgaa
     6361 ggatatggaa aaagctgtag atatcctgga gaaaaaaata tcgcagaaag caaaagtccg
     6421 tattattggt gattatgata ttgatggtgt gacctctaca tacattttaa tgaaaggcct
     6481 tgcgaggatc ggagcagatg tggatactta tattccggac agagttgcag acggatatgg
     6541 gattcatgca catcttatag aaagagcgga aacggaccgg atcgatacga tcgtgacctg
     6601 tgataatgga attgctgcgg ctgctgaaat ccagatggca aaggataagg gaatgacagt
     6661 gattattaca gatcatcatg aggttcctta cagggaggaa aagggagaac gccagatggt
     6721 gcttccgccg gcagatgcga ttttgaatcc gaaacaatat gattgtccat acccgaataa
     6781 aaacctgtgt ggggcagtgg tggcctttaa atatattgca gcactttacg agagatttgg
     6841 tgttccggca gaggagctgg aagattatta tgaactggcg gctattgcaa cagtaggaga
     6901 tgttatggat cttcagggag agaacaggat tctggtaaaa gaagggctgt gccgtctgaa
     6961 aaataccaaa aatcaaggat tgcaggaact gatccgagca aattctctgg aagatgctaa
     7021 aatcacagct tatcatatcg gatttgtgct gggaccatgt atcaatgcca gtggcagact
     7081 ggatacagct gcccgttctc ttgcacttct caatgcaaaa acaaaggaag aagcagcaag
     7141 gcttgccgga gatcttacag ctcttaatca gagccgaaaa gctctcactg agaaaggaaa
     7201 agaagaggca atccggatta tagagactac agagctgaaa aatgacagag tactggtagt
     7261 ttatcttccg gattgtcatg aaagtcttgc cggtattata gcaggcagga tcagggaaaa
     7321 atatcacagg ccggcctttg tattgacggg cggtgagaca agtgcaaaag gaagcggaag
     7381 atcaatagaa agttactcta tgtatgaaga actggtaaaa tgtgcagacc tgatgataca
     7441 gtttggaggt catccgatgg cagcaggtct gtctatagaa gaaaaaaata tagaagaatt
     7501 ccggagacgc ctcaatgtca actgtacgtt gacggacgaa gaattgcgtc ctaagatcgt
     7561 gattgatgtg ccgatgcctg tgtcttatat tacaaaagaa ctggtagaac agatttcgct
     7621 tctggaaccc tttggaaaag ggaatacaaa accggtcttt gcgcagaaaa atctcagagt
     7681 gcttgatcac agtattatcg ggaaaaataa aaatgtagta aaactaaaac ttctcgatcc
     7741 gcaggggatt tcagtggaag gcatttattt cggagaagca gaggattttg tgaactttat
     7801 cagggaaaaa gacattattt ctgttactta ttatccggag atcaacagat tcaggggacg
     7861 agagagtctt cagattatta ttcagaatta ctgttaatat taccgcttgg tttgtaaccg
     7921 ccggtaagcc tggaaataca aatgtcaggg cttaacagta acttgattct gaaataaaaa
     7981 ggtgatatac tataaaatat ttatgagcga acagcaatat aacacacact ggaggagaaa
     8041 taaaatgaag aaaattgaag attatgtatt aagtataccg gattttcctg aaccggggat
     8101 tattttcaga gatattacaa gtgttctgca ggacgcggat ggcctgcagt tggcaatcga
     8161 ctccatgcag gactgtctta aggatataga tgtggacgtg attgcaggaa cagagtccag
     8221 aggctttatc tttggtgtac cgatcgcata taatcttcat aaaccatttg taccgattcg
     8281 taaaaaaggt aaacttcccc gcgaaacagt atctgtaagc tatgatctgg aatatggcag
     8341 tgcagagatt gaaatgcata aagattccat aaaaccaggt cagaaagtgg ttatcgttga
     8401 tgatctgatc gcaacaggcg gtacgatcga agcagcgatc aagctggtgg aacagcttgg
     8461 cggtgaggtt gtcaaggttg tatttctcat ggaacttgca ggtttaaagg gacgcgaaag
     8521 actgaatggg tatgatgtag cgtctgtaat ttgttatgat ggtaaataag cacagctgat
     8581 tgtgcaggac aggcaggtgg gagcatatga cagagataac aaaaagtaca gaagcaaaaa
     8641 aagatgaaat gcaggttgaa aaagagaagc tggaatctgt aaagagagca gatgcggcag
     8701 taaagaccat gcatgatttt acaagtccgg aggtgcttta taaagaactg ataaacagtg
     8761 ttctgaagta tcatccatca acagatattt ccatgataga gaaggcatat aaggttgcaa
     8821 gtgaagctca tgaaggacag aagagaaagt ctggagagcc atatatcatt catcctttgt
     8881 gtgttgccat cattctggca gatctggaac ttgacaaaga aacgatagtt gcaggtcttc
     8941 ttcatgatgc agttgaagat acctggatga cctatgagga agttgagaag gaatttggtt
     9001 cagaggttgc acttcttgtg gatggtgtta ccaagctggg acagttatct tattctgcgg
     9061 ataaagtaga agttcaggca gagaacctca gaaagatgtt tcttgccatg gctaaggata
     9121 tcagagttat tctgatcaag cttgcagacc gtcttcataa tatgcgtacc ttacagtata
     9181 tgcgtcctga aaagcagcag gaaaaggcca gagagaccat ggatatttat gctcctattg
     9241 ccatgcgtct gggtatttcc aagataaagg tagagctgga tgacctgtcg ctgaaatacc
     9301 ttaagccgga tgtatattat gacctggtgc ataaggttgc cctgcgtaaa agcgagagag
     9361 aacagtttgt aggtgcgatt gtaaaagaag ttaagaaaca tatggatgat gccaatatta
     9421 aggcgcaggt ggacggacgt gtaaaacact ttttcagcat ctacaagaag atggtaaatc
     9481 aggataagac tattgatcag atttatgatt tatttgctgt ccgtattctt gtagatacag
     9541 tgaaggattg ttatgctgcc cttggtgtga tccatgagat gtataagcca attccgggac
     9601 ggtttaaaga ttatattgcc atgccgaaac ccaatatgta tcagtcattg cataccacat
     9661 tgatcggacc caacggacag ccctttgaaa tccagatccg tacttatgaa atgcacagaa
     9721 ctgcagaata tggtatcgct gcacactgga aatataagga gtcgtctgac ggaaaggctc
     9781 ctgtaggtaa gagtgaggaa gagaaactga actggctgcg tcagattctg gaatggcaga
     9841 gagacatgtc tgataacaaa gaattcatga gtcttctgaa gaatgacctg gatctttttg
     9901 cggacagtgt ttactgtttc actccacagg gagatgttaa aacacttcca agcggttcta
     9961 caccggtgga ttttgcgtac agtgttcaca gtgcagtcgg aaataagatg gtaggtgcca
    10021 gagttaacgg taagctggtt ccgattgaat atgagatcaa aaacggcgac cgtattgaaa
    10081 tcattacttc acagaattct cagggaccaa gccgcgactg gttgaaactg gttaagagta
    10141 ctcaggcaaa gaacaagatt aaccagtggt tcaagaagga attaaaagaa gataatatcc
    10201 ttaagggcaa ggagatgctt gcgcagtatg cgcgtgcaaa gggatttaag atcgcaaatt
    10261 atacaaaaac ccagtatctg gaggctgttt tgcgtaaata tggtttcagg gactgggatt
    10321 cagtacttgc tgcaattggt catggcggat tgaaagaagg tcaggttttc aataagctgg
    10381 tagaggctta tgataaggaa aataagaaga atctgacaga tgagcaggtt cttgaggctg
    10441 cttctgagac acaggagaag cttcacattg ccaagagcaa gagtggaatt gtggtaaaag
    10501 gaatccatga tgtggcagtc cgtttttcca agtgctgtaa tccgatcccg ggtgacgaga
    10561 ttgtaggctt tgttacaaga ggacgtggaa tcacaatcca tcgtacagat tgcgtcaatg
    10621 tgctgaatat gtctgagacg gacaggacac gattgatcga ggcggaatgg cagcagcctg
    10681 ataccaagga aaaagagaag tatatggctg agattcaggt ttatgcaaat aaccgtacag
    10741 ggcttcttgt ggatctttct aaaatattta cagaacgtaa gatcgacctg cgaagtatca
    10801 acagccgtac aagcaagcag gagaaggcaa ctatttccat gagttttgag attggaagca
    10861 aagaggaact gcgttccctg atcgagaaga tccgtcaggt agagagtgtc attgacgtag
    10921 agagaactac aggctgatca tggaaaaatc tgctggaaca ttattttatg gaactgctgc
    10981 agattgacag aaaggaataa catgaagaat ttagaattac agaaatgtat attaggacct
    11041 gtatatacaa attgctatct ccttaagaat aaagaaaccg gagaactgat cattgttgat
    11101 cccgcagatt gtccggagaa gattgaaatg aagatttccc ggatgaatgg aaaaccggtg
    11161 gcgattcttc ttacccatgg acattttgac cacattctgg ctgcacaggc agtaaaggag
    11221 aaatataata ttccgattta tgcctgtcgt caggaagagg agatgctccg cgaaccttcg
    11281 atcaatatga ctgtacatta tggacaggga tgttctattg tgccggatgt atttctggag
    11341 gatctggatg ttatcagact ggcgggattt tccgttcaga tgatccatac accgggacat
    11401 accaaaggaa gctgctgtta ttatctgaaa gatgaaggtg tattgttcag cggtgataca
    11461 gtgttctatg gctctgttgg aagaacggat tttccgggtg gaagtacagc agaaattgtg
    11521 agaagtctcc ataaactggt agattcgctt cctgaagaga ccgaggtttt ccccggacat
    11581 gatgcatcta ccactattgg ttatgaaaag aggtataatc catttgtgta aaataggcat
    11641 tctgtttaag aacagagatt ttgaacatga tgtttatgaa ctgatcaaag cgttttatcc
    11701 cgaagcggag atacatactc tttatgaaaa tggtgaagca gagtatgacc tccgcttcag
    11761 tgtggaacgg gataatgaca gttatatcat aaaatacgaa aggacagaga atctgtcgaa
    11821 acaggaaaca gagcaaaaag gggtaatttc cgcagacata ctttctaaag agaatgcagg
    11881 ctgtggaata caggatgctc atgctctgag aaaagagaat aaagataata tcaaatatgc
    11941 tctgtatcag ttgttggtaa aactgacggg cagaactctt ccatggggaa atctgacagg
    12001 aatacgtcct gccaaactgg caatgggaat gatcgaatcc ggaatgaaaa atacggaagc
    12061 agcccgggag atgcgtgaga gatatctggt gagtccgcag aaaacagcgc ttgccatcac
    12121 tattgcaaac agggaaagag agattctgaa ggatattgac tatgaaaatg gatacagcct
    12181 ttatattgga atcccgtttt gcccaagtat ctgtctgtat tgttccttca gctcctatcc
    12241 gctgaaagtg tgggagaaga gaacagatga atatgtggaa gctctctgcc gtgaggtaag
    12301 agagactgct cttatgatga agggaagaaa actggacacc atctatattg gcggcggtac
    12361 cccgactaca ctgcttccac atcagatccg taagctcctg gatacagtgg gagaagcttt
    12421 tggctatgaa ggactggcag agtttactgt ggaagccggc agaccggaca gtattacacg
    12481 tgaaaagctg atggcgatca gggagtatcc ggtaacaaga atttccgtaa atccacagac
    12541 tatgaatcag gaaaccctgg atattatcgg ccgcagacat actgtggagc agacaaaaga
    12601 agcgtttcat ctggcacgag agctgggata cgataacatt aacatggatc tgatcgtagg
    12661 actcccgggt gaggatattc acatggtaga gcggactctt gaacaggttc gtgaactggc
    12721 accggacagt attaccgtac attcactggc agtgaaacgt gcagcaaggc tgaatatttt
    12781 taaagagaaa tatcaggaaa tgtcttttga gaataatcag gagattatgg atctgaccat
    12841 gaaaactgcg tatgaaatgg gaatgggtcc ttattatctg tacagacaga agaatatgaa
    12901 gggaaatttt gaaaatgttg gctatgcaaa ggttgacaaa gcgggaattt acaatatact
    12961 gattatggag gaaaaacagc ctatcatcgc actgggggca ggcggttctt ccaagctggt
    13021 ctttgaccat ggacagagaa ttgaacgtgt ggagaatgta aaagacgttt ctaattatat
    13081 ttcccgcatt gatgagatga tcgagagaaa acggacagca atagctacct ggctgtagga
    13141 tgtggaggta acattttgga cacagtacaa aagacagcag caggttcaca gcagaggatc
    13201 ctggaatttg accttgcttc tgaactgcat catggaatgc tggtaagtaa tctggcttat
    13261 gcggttgcag aggagatggg actgccgcat gaacagtgtt atgagcttgc aatagcagga
    13321 atgctccatg atataggaaa gctgaagctg acaagttata ttaacggaca ggagcaggat
    13381 cctctggtga tcgaggaact gaagtatgtc cggatgcatt ctgcattggg atatgaggaa
    13441 cttaaagggc agggatattc ggattttgta ttggagagta tcctgtacca tcatgagaat
    13501 tatgatggta gtggatatcc gtccaataaa gcaggtgatg atatacccat aggtgcccgg
    13561 atactcagag tctgcgatgt ata
//
