LOCUS       c00047_gnlPro..        14532 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FPNDBBIJ_47.
ACCESSION   c00047_gnlPro..
VERSION     c00047_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:20:15
            Original ID  :: gnl|Prokka|FPNDBBIJ_47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14532
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14532
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4919:13335]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4920..13335
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14532
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14532
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             329..817
                     /locus_tag="ctg47_1"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGVVDMRRDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
     CDS             1019..2017
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.1; E-value: 9.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_2"
                     /sec_met_domain="SBP_bac_1 (E-value: 2.3e-18, bitscore:
                     57.1, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSITNVSYDPTREMFEQYNK
                     IFEDHWKEKTGDDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSNTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             2088..2924
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.5; E-value: 5.1e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg47_3"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.2e-26, bitscore:
                     83.5, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVLVKYDFPGKRLMDGMIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSELQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             2924..3748
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 59.2; E-value: 1.5e-18)"
                     /gene_kind="transport"
                     /locus_tag="ctg47_4"
                     /sec_met_domain="BPD_transp_1 (E-value: 3.6e-19, bitscore:
                     59.2, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVGISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRNLIEYKGKKEA"
     CDS             3750..4808
                     /locus_tag="ctg47_5"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLEIPDSGEVIIDGKVVNDVPASQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVEQVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             4920..6665
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.4; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_6"
                     /sec_met_domain="FAD_binding_2 (E-value: 6.4e-23, bitscore:
                     71.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-08,
                     bitscore: 25.0, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEALERGGEQELSQTAIAKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLILCQAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEK
                     GAGER"
     CDS             6662..6976
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_7"
                     /sec_met_domain="Fer4_9 (E-value: 2e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.9e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.9e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             7007..8125
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_8"
                     /sec_met_domain="PAPS_reduct (E-value: 4.5e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTICGRFCSDEGVVAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNVSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             8127..9767
                     /locus_tag="ctg47_9"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYADQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIENQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             10437..10691
                     /locus_tag="ctg47_10"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             10664..10792
                     /locus_tag="ctg47_11"
                     /transl_table=11
                     /translation="MAGYAAWDVSMLLFTATHSRELGYVKSNVSITAEGNDIYEKI"
     CDS             10770..11552
                     /locus_tag="ctg47_12"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLTACIAAVCMFSDVHGAEVAGPPAPKSKSALT
                     QKPEATPMPEATPIPASTPTPEQETETDKQNPADQGTLSKPDHPDTISADKLVFIGDSR
                     TEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIEDNTAVIILMGVNDLYHVNDYI
                     SYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEIESFNAAMQASLSGVTYIDVYSHL
                     VSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQMSGIWG"
     CDS             11818..13335
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_13"
                     /sec_met_domain="Fer4_7 (E-value: 1.3e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.6e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.4e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTIM
                     ALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFHASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             13274..13399
                     /locus_tag="ctg47_14"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKAWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(13507..14412)
                     /locus_tag="ctg47_15"
                     /transl_table=11
                     /translation="MHERDTDRVRLSLPKTLKKYMEETYQLHENFLYLENKIFRGMDQI
                     KQLRIYPPEKGSCKIIVVYEVPDQEELPQNGHELSIDLGLHNLMTCYDSENGNTFILGR
                     KYLGLERYFHKEIARVQAQWYGQQSGKGVKHPTTSKHIRKLYKRKHDSVTDYLHKVTRY
                     LAEYCREQGITCVIAGDIRNIRREKDLGHRTNQKFHSLPYNRIYIMLEYKLKRYGIRFI
                     KQEESYTSQCSPLSPKVEKRYAEPSKRKERGLYRDGNRTYNADAVGAYNILRKYHSVSG
                     VKRELSVTGLKTPEIIKVAV"
ORIGIN
        1 actgttcaca caccactatc ccgcgaggtg ttttggcatg aatatgccaa aatcccgaga
       61 catacaagcc aaaattccat tgccgcaggc aatctggaat gaattttggc tacgttactg
      121 tgaacggagt gaacagtaac gttccctgat tcacactgca ggtactgaaa aaatccttga
      181 ctttttttat aacagtccgt ataataatca acggtaaatt tgtgaaacag atatttggta
      241 ttattggaaa cggtacatcc tcctggatgg ttatgaacaa cacaaatctc taattgatgt
      301 tattcatact atctaaggag gattttttat gcctaaaaac aagtttcagg aagttatttt
      361 tacgattatc atggtgtttg taatggttta tgccatgatc tgctacaaca ttgtactgaa
      421 cacagggaca atgacaaatg agacatttct gttagctttt catgaattaa cattcatggg
      481 accgattgca tttattcttg atttctttat catcggtggt cttgcaaaga agattgcatt
      541 tggtgttgtg gatatgagaa gagataatcc gttccacctt gtacttgcaa tctcagcagt
      601 atccgttgca tttatgtgtc catgtatgag ctttgcggca actgtgctga tcaaacatgc
      661 accggcaagt cagatcattc ccacatggct ccagacaaca gcaatgaact ttccgatggc
      721 attcttctgg cagatttttt atgccggacc attcgtaaga tttattttcg gaaagctttt
      781 tccggagaaa gaaaaggcag cagcttctgc cgaataaaaa atatgtaatt ttgactgcag
      841 cattctgtat ttcaggatgc tgcttttttg tgttcttatc tacacaacat aaattgtact
      901 tattttaata cactattgac aaattctgtc atttcttgta atatcatata aaacatatcg
      961 aataactatg aaaagtagag aatgcaaaaa actactggta ccttaaagga gatgaaacat
     1021 gatcagaaaa ttatttgcct ttggtcttgc agttgtactg gcactgatgc cggtacaggc
     1081 ttttggaaaa acggtgtcta tcactaatgt ttcctatgat cctaccagag agatgtttga
     1141 acagtataat aaaatatttg aagaccactg gaaggagaag accggggatg atgtggaagt
     1201 gatacagtcc catggtggtt cagggaaaca ggcacttgag gtagccaatg gtctggatgc
     1261 agatgtggta accctggcac tggaatatga tatagagtct attgaaaatg cagggctgat
     1321 caaggcagga tggaaagata aatttgacaa tgacagttct ccttatacat ccactatcgt
     1381 atttctggtg aagaaaggaa atcccaggga tatcaaagac tgggacgatc tgacgaaaaa
     1441 aggagtggga gtagtaacac caaatccgaa aacctccggc ggtgccagat ggaactacat
     1501 ggcagcgtgg gcttacgcag ataaaaagta tggtggcgat gaagcgcaga tgaaggaatt
     1561 tattaagaaa ctttaccgga atgtggtggt tcttgactca ggcgcaagag gtgcaacgac
     1621 ctctttcgtg gagaacggac aaggagatgt gctggttgcg tgggaaaatg aagcttatct
     1681 atccatgcgg gattatccgg atgagtatga gattgttact ccaagcgtaa gtattctggc
     1741 acagccttct gtggcggtgg tagatgaagt ggtggattac agagatacaa gagatgtggc
     1801 aacagagtat ttgaattatc tgtattccga cgaagcacag gagatcgcag cagagaatta
     1861 tttccgcccc accaatgaga aaatcctgaa gaagcacagt aatacgtttg atctgaatat
     1921 aaatctggca aatatcagtg attatggcgg atgggataaa gtgcaggaga aacatttcac
     1981 agatggcgga attttcgatc agatttatga gagataaagg aagacaagat gaagcaagag
     2041 cataagcaca gacagaatat atgagacagg agaggtggta attgattatg aaaaaaagaa
     2101 ataaaccggt gattccaggg tttgggctct ccatgggaat taccatttcc atattgagtc
     2161 tggtagttct gattcccctg gcaagcctgg tggtctacac agcgaagctg agttttaaag
     2221 attttatcga aaccatcaca agggccagag tgctggcatc cttttatacc agttttgtat
     2281 gtgcttttgc agcagcagta ataaatggaa taatgggaac tattcttgcg tgggtgcttg
     2341 tgaaatatga ttttccgggc aagagactta tggatgggat gatcgaactt ccctttgctc
     2401 ttcccacagc ggtagcgggt attgcactga catccctgac ctcagattcg ggaattgtcg
     2461 gcagcttttt tgcaggattc ggtatcaaga tcgcatacac aagaataggt attacagtgg
     2521 ctatgatatt tgtaggaata ccgttcgttg tgcgaagtgt acagccggtt ctggaaaaga
     2581 tggataattc ttacagcgag gcagcaggag tgctgggagc aaagaaaaca actatcttct
     2641 ggaaggtcat ttttccggaa ctgaagcccg cgatctttgc gggaaccgga cttgcgttcg
     2701 gaagatgtct gggtgaatat ggaagtgttg tatttatcgc aggaaataaa ccctattata
     2761 cagaaatcac accgctggtt attatgtcag agcttcagga atttgattat tcaagtgcaa
     2821 cggcaatcgc acttgtgatg ttggcagttt catttttcat tctgtttctt aacagtatga
     2881 tacagcagag aaatgcaaga attttaagag gaggaaatgc ctgatggaca acaatgaaaa
     2941 gacttcggag aaaattacaa aatggctgct tgtcgggatc agtgttctgt ttctggcagt
     3001 catgctcctt cttcctctga tcactgtgat cacagaagca ttgcggagcg gatggaaggt
     3061 ctatgcagct gcagtgacag atgagtacac catcaaagca cttcttctta cagtgaaggc
     3121 aacactcttt gcagttgttt ttaacactgt ttttggtgtt tttgcagcct gggcactgac
     3181 gaagtttcag ttcaggggta aaaagcttct cactaccctg atcgaccttc cggttactat
     3241 ttcccctgtt attgcaggtt tgatctttct tctgattttc ggacgacaga gtcctgttta
     3301 cttttttctc atgaagttag ggattaaagt tgtattctct gtaccgggaa tcattattgc
     3361 aactgtattt gtaacctttc cttttatttc cagagaactg attccggttc tggaagcaga
     3421 aggaagcgat gaggaggaag cggcagccct gatgggagca ggtggatgga ccattttctg
     3481 gaagatcaca ttccctcata tcaaatgggc attactgtat ggagttgtgc tctgtacggc
     3541 aagagcaatg ggagagtttg gagcggtatc tgtactttcc ggacatttaa gaggaaagac
     3601 caatacactt cctcttcatg tagagatttt gtttaatgag tttcagtatg ttccggcgtt
     3661 tgccgtatct tcgctgcttg tgatcatggc agttatcatt ctggtagtca gaaacctgat
     3721 tgaatataaa ggaaagaagg aagcctgata tgtatgtaga gttaaaaaat atcaataaga
     3781 catatggttc ttaccaggca tcaaggaatg tgaatttcgg aattgagaaa ggtaaactga
     3841 ttggtctgtt gggaccaagc ggaagcggaa aaacaactat tcttcgaatg atcgcaggtc
     3901 tggaaatccc ggacagcgga gaggtcatta ttgatggaaa agtggtaaat gatgttccgg
     3961 ccagtcagcg tgggattgga tttgtatttc agaattatgc gttgtttcgc tatatgacag
     4021 tttatgataa cgttgcattt ggtttgaagg ttcagaaggc tgataagaag aaaattgatg
     4081 ccagagtcag agagctgatc aaactggtgg ggctggaagg actggaaaaa agatatccaa
     4141 gccagttatc tggcggccag aggcaaaggg tggcatttgc cagagccctt gctccaaatc
     4201 cccaggtgct gcttctggat gagccctttg cagccattga tgcaaaaatc cgtcaggaac
     4261 tgcgaagctg gttaaaagag atgatcggaa agctgggaat taccagtatt ttcgttactc
     4321 atgatcagga tgaggccatt gaagtagcag atgagattat tatcactaat gcaggacgga
     4381 tcgaacagaa aggaactccc ataggggttt acagaaatcc tgagacagct tttacagcgt
     4441 ccttcttcgg acagccatct gtgttgaaaa atgcggatga tttccatacc tttgctcagg
     4501 cagaaggagc agacaagatt attgtccgcc cggaatttgt aaaaatctcc aaactggatg
     4561 aggtggagaa gttcaaaact tccgtatccc ggggagtggt tgaacaggtt tctttcaggg
     4621 gagataatct ggaacttcag gtgagagtca acaattccgt agtaactgcc agaagaagcc
     4681 tggagaaagc agatatccgg gaaggtgaga ctgtgaatgt attcctttac aggatttttg
     4741 cactgagagg tgacagtgta cagctgatcg aaaatgaggc tgtaagggat gactttgtaa
     4801 ttatctgaca gcggtggctg cggcgactga cgataatgaa gaaataagaa attcagacgc
     4861 aagactgatc gggaaatcaa cttgttggca cactggtatg gaggaaaggg taagagagaa
     4921 tgagaacaga gagaatcagg acagatgtgc tgatcatcgg cggcggtacg gcaggatgct
     4981 ttgcagccta tgtgatcggc aaaaaaagcg gcagaaaagt tctgatcgca gagaaagcga
     5041 atattaagcg aagcggatgt ctggcggcgg gcgtgaatgc attgaacgca tatattacag
     5101 aaggcagagt gccgcaggat tatgtggatt atgccaaaaa ggatgcccat ggaatcgtaa
     5161 gagaagacct tcttcttacc atgtcagaga gactgaatca tgtgacaaag gtgatggaag
     5221 atctggggct ggtcatcctg aaggacgaaa acggaaaata tgttgccaga ggaaaccgaa
     5281 acatcaagat caatggcgaa aatatgaagc caatccttgc aaaggcggca gctgaacagg
     5341 agaatgttac ggttctcaat catgtaaata ttacagatta taaaacagaa aacaaaaaag
     5401 ttacaggcgc agttggattt agcgttaatg aggatatttt ctatgacatt gatgcgaaag
     5461 cagttctttg tgccacaggt ggtgcagcgg gactttacag accgaataat ccgggatttt
     5521 ccagacataa gatgtggtat cctccgttta acacaggtgc aggatatgca atgggacttc
     5581 tttccggtgc ggagatgaca acctttgaga tgcgtttcat tgcattgaga tgtaaggaca
     5641 cgattgctcc tacaggaact attgctcagg gtgttggggc cagacaggtc aatgcacatg
     5701 gtgatattta tgaaacaaaa tatggtctga caacttccca gcgagtttac ggtacagtca
     5761 tggagaacag agaaggaaac ggtccatgtt atctcagaac ggaaggtatt tccaaagaac
     5821 aggagcagga cctttacaaa gcttacctga atatggcacc gtcccagact ctgaaatgga
     5881 tggaagccgg aaaaggacca tccgaagaga atgtagagat tgagggcaca gagccatata
     5941 ttgtaggcgg acatacagcc agcggttact gggtagataa taacagagct acaactattg
     6001 aaggtttata tgcagccgga gacgtagcag gaggatgtcc gcagaaatat gtaaccggcg
     6061 cactggcaga aggtgagatc gcagcagagg cgattttgga atatctgaat ggcaaagatg
     6121 atgaccggat cgcagcagaa aataaggaag aggctttaga gcgtggcgga gaacaggagc
     6181 tgtctcaaac tgcaatagct aagaaggcag aatacgaatc acatttgaat gcttcccgtt
     6241 ctttgatgaa tgcagagcag cttgaggaag ccatgcagaa gatcatggat cagtacgcag
     6301 gaggaatcgg tacagactac agatacagcg ggatgagtct tgcaaaggca gatgaaaaga
     6361 tcgcagcatt gttgccagta gttgacactc tggcagcaac agatacttat gaactgatgc
     6421 agatttatga acttcgcgaa cgactgatct tgtgccaggc agtgatcgca catctggcag
     6481 ccagaaagga aaccagatgg catagtttcg gagagaatac agactacccg cagcagagcg
     6541 aagagtggat gaaatatgta aactcccgta tggaaaacgg cgagattaag atcttatatc
     6601 gtgacctgat cacaaaggaa aatacaggtt tgaatacagc agagaaagga gcaggtgaga
     6661 gatgagcatt cggattcaga aaagtaaatg tgcaggatgc ggcagatgta tcgaagcctg
     6721 tcccggaaat ctgatcaaaa aggataaaga gaacaaagcc tttatccgtc aggtaagaga
     6781 ctgctggggg tgtacttcct gtattaagga atgcaggcat gatgccatcc gctttttcct
     6841 tggcgctgat gtgggaggca gaggtgcaag tatggttgta tcagagaaac cggatatttc
     6901 cacatggaca gtggagaagc cggatggcac taagatcact attcaggtta ataagaaaga
     6961 cgctaataaa tattaaacat aagtatgtac tctcagagtc tttagagtgt gtttgaaaaa
     7021 tgctttacgc aagatgtgcg tcacaatttg tgggagattt tgttcggatg agggcgtcgt
     7081 agcgggctac gacaaccgaa ttcggacaaa atataccgca aagtggggcg tgcagattgc
     7141 gggaatgatt tttcagacac gctctagtgt atttgctcaa gtacgaaaag attccgagta
     7201 taaacaaaca gaggaggata atgcaatgag taacgtatct catcttgatg cgcttgaggc
     7261 agaggcgatt tatattatgc gagaagtagc agccgagtgt gaaaagccgg ttatgctcta
     7321 ttctatagga aaggacagct ccgttatgct ccatctggcg atgaaggcat tttacccgga
     7381 gaaacctcca ttcccgttcc ttcacattga tactacatgg aaattccatg agatgatcga
     7441 attccgcgac agaatcgcaa aggaaaacgg aattgatatg ctggtttaca ccaatgaaga
     7501 gggtgtaaag gcaggaatca atccatttga caatggttct gcatatacag atatcatgaa
     7561 aacacaggcg ttaaaacagg ctctgaccaa atatggattt acagcggcat ttggaggcgg
     7621 ccgccgtgat gaggagaaat ccagagcaaa agagagaatc ttttctttcc gtaattcagc
     7681 tcaggcatgg gatccgaaaa accagagacc ggagatgtgg aagctttata acactaagat
     7741 ccagaaggga gagagtatgc gagtattccc aatttccaac tggacagaaa aggatatctg
     7801 gcagtacatt cagcgtgaaa atatcgaaat tgtaccgtta tattttgcga aagaaagacc
     7861 ggtcatctac agagacggaa atatcattat ggtggatgat gacagattaa aactccgtcc
     7921 gggtgaaaag attgaaaaca aaaaagtcag attccgtact cttggatgct atccgcttac
     7981 tggaggtatt gaatctgaag cagatactct ggatgagatt attgatgaga cgttaagtgc
     8041 tgtttcttct gaacgtacca gcagggtgat cgaccacgag gcagcaggca gcatggagag
     8101 aagaaagaga gaggggtatt tctagaatga aaggattatt gaaatttatt acatgcggaa
     8161 gtgtggatga tggaaaatcc actctgatcg gacatattct ttatgatgca aagcttctct
     8221 atgcagatca ggagaaagct ctggagttgg attccaaagt aggaagcaga ggcggtgcca
     8281 ttgattattc tcttcttctg gacggtctga tggcagagcg tgaacaggga atcaccattg
     8341 atgttgcata ccgttatttt acaacagata acagaagctt cattgttgca gatacacccg
     8401 gacatgaaga atatacaaga aacatggcag tgggtgcgtc ctttgcagat ctggcagtta
     8461 tcctggtgga tgcttcacag ggagtactgg tacagacaag acgtcatgca agaatctgcg
     8521 cattgatggg aatccgttac tttgtatttg cagtaaacaa aatggatctt attgaatatg
     8581 atgaaaaacg tttccgcgac attgagaatc agatcgcagc actgatagaa gaactgaaac
     8641 ttgccaatgt aactattatt ccggtatctg ccacagaagg tgacaacgtt acaaccaaat
     8701 ctgacaacat gccatggtat aaaggtgagg cgcttctttc ccatctggaa accgtagaca
     8761 ttaaggaaga tacagagaag ggcttctata tgcctgtaca gagagtctgc agaccaaacc
     8821 atgagtttcg cggattccag ggacagattg agaatggtgc catcagggca ggcgaccttg
     8881 tgactactct tcccagtaaa gaagaagctc atgtaaagag tattcttgtt ggcgataaag
     8941 aagttcagga agcggtacag ggacagcctg ttaccatcca gcttgacaga gaagtagatg
     9001 tttcccgcgg atgtgtactt accattgatt ccggcgcagt tcttacagac tctgtggaag
     9061 cagatatcct ctggatggat gacaatgctc ttacggatgg caagaacttc tttgtaaaaa
     9121 tcggtacaaa gatgatcccc ggcctggtta caaagatcaa ttattctgtg gatgttaata
     9181 caggtgaaaa gaaaagcgca tataccttaa agaagaatga gattgcttcc tgtactctgg
     9241 aattctcaga gaagatcgtt gtagacgaat ttgacaggca cagaacactg ggtgagctga
     9301 tcctgataga tcgtgtcaca aatatgactt ctgcctgcgg tgttgtgaga aaaacctttg
     9361 tttctcagga tagatctcag atcggaaaag tggatgagca ggttcgtgca ggactgaaag
     9421 gtcagacacc ggtagtagtg gaattcccga tcggtaaaga aggaatcact cttgattttg
     9481 cagagcaggt agaaaaggga ctgactgtac ttggaaaaca tacctatctg tatcatccgg
     9541 cagcgagtga aaactatgca gaaactgtcc gccatcttaa ggcagcaggt ctgatcgtac
     9601 ttcttgttct tgatgaaaat acagcaaaag acgagacatt aaagactctg gatggtttct
     9661 atgcgaactg gcagattgac ggaattactg tgaaagatgc gattgatttc gtgaaaaaga
     9721 aatctgcatt tacagtgcag agtgtacatg atggaaatta tatctgatta taacagggct
     9781 ataaatcgcc gcagagacaa agaaagtctc tgcggtattt tgttttcttg acaagtgtcg
     9841 ttacagcgga ttatacttat tttcaaatat ccagaatcca taataataca gacaggaaag
     9901 ataacagaaa tatgcaaacg aacaatgaaa gtaaacaaaa ccaaaaaaag agatgatgct
     9961 tggaactttg tttgtaattg ctacgatcat catcctggcg ataccaacga agaaaagaca
    10021 gaaataaaga tgagtgaata tcgatcagaa tgtagaatgg gcaattggtt actgttcaca
    10081 caccactatc ccgcgaggtg ttttggcatg aatatgccaa aatcccgaga catacaagcc
    10141 aaaattccat tgacacaggc aatctgaaat gaattttggc taagttactg tgaacggagt
    10201 gaacagtaac ggcaattgtg aagtggcatt cagattacat attatgcagc agagtatgat
    10261 ataattcgtt ttgtataatg gcgtcaggat taagagcata tgtagagctg tgtagcgaag
    10321 cggattgcga atatctgttt gacttttgat gggtgtacac gagaacattt ttttacagtg
    10381 aaagttatct gtattatatt acagaaggta ctgtacagat aatcaggagg tattttatgc
    10441 gtttggaaaa agtacaggaa gcgttaaaaa caaagaaaat tcattatgaa tatacagagg
    10501 aaaacggatg cggaagcatc gactttatgt ttcgcggtct gagattccat atatgggaat
    10561 atgaagatcg tgtctgggga gcggagacaa acgtgttcga agcaggcaga agccaggata
    10621 ttgagggaga ttacgaggaa attatttccg gagaaatcct ctcatggccg gatatgctgc
    10681 ctgggatgta agtatgttac tgttcacagc aacacactcc agggagttgg gatatgtgaa
    10741 aagtaacgta agtattactg cagaagggaa tgatatttac gaaaaaatat agaaccggac
    10801 aaatcgtatt aaccgcatgt attgcagctg tctgtatgtt ttcagatgtc catggggcag
    10861 aagtggcagg tccgccggca ccgaaatcca aatcggcact gacacaaaaa cctgaagcaa
    10921 caccaatgcc tgaagcaaca ccaatacctg catctactcc aacaccggag caggaaactg
    10981 agacagataa acagaatccg gcagaccagg gaactttaag caagccagac catccggaca
    11041 ctatctccgc agataaactg gtatttatcg gagattccag aacagaggga ttgagggatg
    11101 cggtaaacga tgacagcatt tggtcctgtc tttcttctat gggatatgac tggatggtat
    11161 ctacaggagt gccgcaggta gaagatcaga ttgaggacaa tacagcggtt attatcctga
    11221 tgggtgttaa tgatctttat catgtcaatg actacatcag ttatattaat tccaaagctg
    11281 ctgaatgggg gaacagagga gcgcagactt atttcgtgtc tgtaggtccg gtgcagaatg
    11341 atccctattg cagtaatgcg gagattgaaa gttttaacgc ggcaatgcag gcaagcctga
    11401 gtggagttac ctacatagac gtatattccc atctggtatc tgagggattt tccaccgtag
    11461 acggaaccca ctatccggac agtgtgtccg tagatattta taattatatc ttggaccatc
    11521 tggaggaaca gatgagtgga atctggggat aacaacatat gaacagcaac ttcgggggcg
    11581 acaattcagc gaaaattctg atgttgtgtt gagcctggaa gcatttggtg atatgatatg
    11641 cagataagga aacggaaatg agcggaattt cgtttctctg tgaagtggct gaaagttcag
    11701 caggaggaaa aatgagtgtg ctgattgcag cagtgatgaa attataaatg gaaattgttc
    11761 ggtgtccctg cattggattg ccgtacagtt atccgaatcg aaaatcagga ggaaaaaatg
    11821 agaggactgt attcatccaa aacagaaatc agacacaaaa tttttacaga aattgcgagg
    11881 atggcatatg aaggccagtc tccggagatg ctggaagagc ttccctacaa gatcgtaccc
    11941 ggtgaaattg cgacttatcg tgacagtatt tttctggaaa gagcggtagt tggtgagaga
    12001 cttcgcgttg caatggggat gtcactgaga aaggttacag agcatgcgcc aatttccaaa
    12061 ggtgtggagg ccagcgttat tgaggaaaag tattatgaac cgccgcttat caatgtgatc
    12121 aagtttgcct gtaattcctg ccctgaaaaa agggtaatga tcacagaggg ctgtcagggg
    12181 tgcctggagc atccctgtgt ggaagtctgt ccaaagaaag cagtgcatat ggaaggcggc
    12241 agatcccata ttgatgaaga tgcctgtatc aaatgcggaa agtgtctgga agcctgtccg
    12301 tataatgcaa tcatcaaaca ggaacgtcca tgttcaaagg catgtggtat gaatgctatt
    12361 ggctctgatg aatatggaag agcagagatt gatcaggata aatgtgtatc ctgcggacaa
    12421 tgtctggtaa gttgtccgtt cagtgctatt gtagacaaag gacagatttt ccagactatt
    12481 atggcattaa aaagtgaaac accggtgtat gcaatcgtgg cgcctgccat tgcaggccag
    12541 tttccgggta tggagaataa taagatacgg ggagcatttc aggcacttgg ctttacagat
    12601 gtaagagagg ttgccgtcgg tgcagatctg tgcacagtgg aggaggcaaa ggactttttg
    12661 gaagaagttc ctgagaaact tcctttcatg gctacatcct gttgtccgtc ctggtctatg
    12721 atggctaaga aattattccc ggaacaggcg aaatgtatct ctatggcact gacacctatg
    12781 gttctcactg caaggctgat caagcagaag gaaccagatt gtaagatcgt tttcgtaggt
    12841 ccctgtgcag ccaagaagct ggaagccagc cgtaagagta tccgcagcta tgtggatttt
    12901 gtgctgacct tcgaggaagt agcaggaatg tttgatgcca aaggcgtgga ctggaaagat
    12961 attccggaag gagaaccact gtttcatgcc agtgctgacg gaagaggttt cgcagtcagc
    13021 ggtggtgtgg cagaagcggt tgtccatgcg gtgaagcgta ttgatcctga tcgggaagta
    13081 aaggtaatga atgcagaagg tctgcagaac tgtaagaaga tgctccagat ggccaagatt
    13141 ggtaaatata atggatatct tttggaagga atggcatgtc cgggcggctg tgtagcaggt
    13201 gccggtacta tccagacagt taaaaaagca gcagcagctc tcgaaaaaat gaagaaagag
    13261 gcttcgttta cagatgccta tgactccaaa tacagagcaa gactggaaag cctggagaaa
    13321 tttgatgtgg agtgagattc tgactgaatc agtgaaatcc tatatggatt gcaagtgttt
    13381 gaatgcaatc agtatatagc agagtgaatt actcggcaac tgagttacca gagcatctga
    13441 attaaggcgg gataccgcct tttttcaggg tgcatccatg acaccactac tgtttgctct
    13501 ttagagttat acagctactt ttattatttc cggtgttttc agtccggtta cggacagttc
    13561 tctttttact ccggatacgg agtgatattt tctcaggata ttatatgcgc ctacggcatc
    13621 tgcattatag gttctgtttc catctctgta caaccctctc tctttccgtt tggacggctc
    13681 tgcatatctt ttctccactt tcggtgacag cggactgcac tggctggtat aactttcttc
    13741 ctgttttata aaacggatcc catatctttt cagcttatat tccagcatga tgtagatcct
    13801 gttatacggc aggctgtgaa acttctggtt tgtcctgtgt cccaggtctt tttctctccg
    13861 gatattccgg atatcccctg caatgacaca ggtgatcccc tgttcccggc agtattctgc
    13921 aagatacctt gtgaccttgt gcagataatc cgttactgaa tcatgttttc tcttatataa
    13981 cttcctgata tgttttgatg tggtcggatg tttgactccc tttccggact gctgtccata
    14041 ccactgggcc tgcacccttg cgatctcctt atggaaatat ctttccaatc caagatactt
    14101 cctgcccaga ataaacgtat tcccattttc agaatcataa cacgtcataa ggttgtgaag
    14161 tcccagatca atagacagtt catgtccgtt ctgtggaagt tcttcctggt caggaacctc
    14221 ataaacaaca ataattttac agcttccctt ctccggcgga tagatccgca gctgtttgat
    14281 ctggtccatg cccctgaaaa tcttattttc aaggtaaaga aagttttcat ggagctgata
    14341 tgtttcttcc atatattttt ttaatgtctt tggaagggac aggcggactc tgtccgtatc
    14401 ccgctcatgc atgatcccca tctgcatcta ggtaatgtgg atactttcct gattaaaccg
    14461 cggcggtctg ggatcctcga tccccccgga tcgtttcagg gcataaaaag acttccatgc
    14521 ctggtccagc ag
//
