LOCUS       c00021_gnlPro..        15109 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NODIPJOO_21.
ACCESSION   c00021_gnlPro..
VERSION     c00021_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:32:02
            Original ID  :: gnl|Prokka|NODIPJOO_21
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15109
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15109
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6180:14916]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6181..14916
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15109
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15109
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             295..1386
                     /locus_tag="ctg21_1"
                     /transl_table=11
                     /translation="MEKFKAFLRRKDIEISIKRYGIDALGAMAQGLFCSLLIGTIINTL
                     GTQFHISFLTTAVATVNDTQYTVGSLASAMSGPAMAVAIGYALHCPPLVLFSLITVGFA
                     SNALGGAGGPLAVLFVAIFASEIGKAVSKETKIDILVTPLVTIGVGVALSAWWAPALGS
                     AAMKVGNIIMWATNLQPFLMGILVSVFVGIALTLPISSAAICAALGLTGLAGGAAVAGC
                     CAQMVGFAVMSFRENKWGGLVSQGIGTSMLQMGNIVKNPRIWIAPILTSAITGPLATCL
                     FKLQMNGTPVSSGMGTCGFVGQIGVYTGWMNDIAAGTKTAVTGWDWAGLLLISFILPAI
                     LCPLINMFIRKLGWVKDGDMTLS"
     CDS             complement(1576..2232)
                     /locus_tag="ctg21_2"
                     /transl_table=11
                     /translation="MAKKKIYAVRKGHKTGLFVTWAECQKAVSGYSGAEFRGFTEKEEA
                     LAFLNMETTGNVSGDKAKEAAGIVEVPENMVIAYVDGSFEKSIGRYAFGCVILTPDGQE
                     IRKSGSGSDPAGVAIRNVAGEMLGSMTAVNWAIENKYPAVEIRYDYEGVEKWVTGMWRA
                     KTPLTSKYAAHMQEAGKKVKISFCKIAAHTGNHYNEEADQLAKSALLKMDEEVRI"
     CDS             complement(2513..3697)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     374.1; E-value: 2e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_3"
                     /sec_met_domain="Fe-ADH (E-value: 3.8e-115, bitscore:
                     374.1, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPFEFFIPQNITVGAGTLAKLPECAKKLGGSHAMLISGPTLRKM
                     GVVDKAADYLKDAGMAVDIFTDVEANPSVTTVEKATEAYKDSGADFIVALGGGSPMDVA
                     KAVGVTAKYGGSITEYEGAHKVPGKIVPLIAIPTTAGTGSEVTAFSVITDHSRDYKLTV
                     FSYELLPAYAILDPELLTSAPASVAAACGIDAFIHAEEAYVSTAASPFSDAMAEKAMEL
                     IGGNIRRFVARRTDLEAAEAMLTGSLFAGIAFSFARLGNVHAMSHPVSAFFNVAHGVAN
                     AVLLPVIAEYNALADHGRYLKIYNYISPIPAYEDEFEPLMLVDAIRELNEDIGIPEDLT
                     TAIRQAKKGEEISDEEIESKIDAMADDAMKSGNIAVNPRSSRKQDIVELYHKAL"
     CDS             complement(3809..5329)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_4"
                     /sec_met_domain="AA_permease_2 (E-value: 5.1e-47, bitscore:
                     150.2, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKTSEFDKVLGAWDILVIAFGAMIGWGWVVSSGNWIESGGVLG
                     AAIAFAIGGIMIFFVGLTYAELTAAMPQCGGEHVFSYRAMGSTGSFICTWAIILGYVSV
                     ACFEACAFPTIITYLWPGFLKGYLYTAAGFDVYASWLIVAIVIAFLIMIININGAKTAA
                     VLQTVLTCIIGGAGIILIVASVVTGSVDNLQGQMFVGNGTGEAMKSIIKVAVITPFFFI
                     GFDVIPQAAEEINVPLKKIGKMMILSVVLAVVFYSLVILAVGYILNPAEIIESQQGTGL
                     VTADAMAKAFGTKVMAKVIIVGGMCGIITSWNSFLLGGSRAMYSMAESYMIPPFFAKLH
                     PKHKTPVNSLYLIGALTMLAPFAGRTMMVWICDAGNFGCCLAYCMVSVSFLILRKKEPD
                     MARPYKVGHYKFVGFMAVVMSGLMLLVYCIPGSGGSLVFQEWLMVGSWSLLGVVFYAIC
                     KRKYKEDFGKLIELISDEDAASLMPEADDEELDVVIDAAIDRVLSSMA"
     CDS             complement(5333..5953)
                     /locus_tag="ctg21_5"
                     /transl_table=11
                     /translation="MKHLVITIGCEYGAKGNAIGKKIAQDLGIKFYDRDLVDEIIKEVG
                     IPTDIMDRVEEGGTIAGKGAQGDVRGSFSKYADLTDRAIHVQKQIIRKLAQKEACVIIG
                     RSADYILKDTEGIQLVRAFIYAPNDVRVHNIMESHNLSEKDAKLLLDEKDKRYHKRHLA
                     LTGSNRGDRHNRDILINSDFLGIQGTAEYLEDLIAKKYGKKEA"
     CDS             complement(6181..7398)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: Beta_elim_lyase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_6"
                     /sec_met_domain="Beta_elim_lyase (E-value: 1.5e-08,
                     bitscore: 23.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_3 (E-value: 1.9e-110, bitscore:
                     358.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDTGLTFQDIKDKVNKYMIETYERFDFLAETAEGMYIYDENK
                     TPYLDFYAGIAVNSAGNCNPKVVAAAKDQLDDIMHTFNYPYTIPQALLAEKVCETIGMD
                     KIFYQNSGTEANEAMIKMARKYGIEKYGPNRYHIVTAKMGFHGRTFGAMSATGQPGNGC
                     QVGFGPMTYGFSYAPYNDLQAFKDACTENTIAIMVEPVQGEGGVHPATMEFMQGLRKFC
                     DENDMLLLIDEVQTGWCRTGAVMSYMNYGIKPDIVSMAKALGGGMPIGAICATAEVAKA
                     FTAGSHGTTFGGHPVSCAAALAEVNELLDRDLAGNAKKVGDYFAAKLEKLPHVKEVRHQ
                     GLLVGVEFDDTIGGVDVKHGCLDRHLLITAIGAHIIRMIPPLIVTEEECDKAVAIIEDT
                     IKSLEK"
     CDS             complement(7909..8463)
                     /locus_tag="ctg21_7"
                     /transl_table=11
                     /translation="MDYLSNNVAVNLKRIRKSKSMSLDQVSEQTGVSKSMLAQIERGTA
                     NPSLGVLGKITSGLRIEFQELIQPPRVDCCLVTPAELVPTKEIAGQYRVWTCLPYEDTR
                     LVEVYRIEVEPGGVYISGSHGEKTREYLAVMEGVLTLECHGEKYEIHRDQVFKFETDQE
                     HVYRNTGKEKACCTCFFLDYH"
     CDS             9309..11027
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_8"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.6e-49, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             11045..11554
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_9"
                     /sec_met_domain="ALS_ss_C (E-value: 1e-22, bitscore: 70.0,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYDKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(11623..12879)
                     /locus_tag="ctg21_10"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERRRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             13642..14355
                     /locus_tag="ctg21_11"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             14620..14916
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_12"
                     /sec_met_domain="ALS_ss_C (E-value: 1.4e-22, bitscore:
                     69.5, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVHGGSVGIESISMMER"
ORIGIN
        1 ctgctgatat tttcatcaat gcagtattgg caaattgatt aagttaatga cattgcttca
       61 ctccgttcac agtaacgtac caaaaattca ttacagattg cctgcggcaa tggaattttg
      121 gctggtatgt cttgtgattt tttcataatc atgccaaaac acctcgcggg atagtggtat
      181 gtgaacagtt acaaaactac ttgatttact ccgtgaatgt gactataatg agaaaagcgt
      241 atataggtgt atatacaccc ttctatacat aataaaaaca ggagaaagta atctatggaa
      301 aagtttaaag catttctcag acgcaaagac atcgaaatct ccataaaacg ttatggaatc
      361 gatgcccttg gtgccatggc gcagggtctt ttctgctcct tgctgatcgg cacgatcatc
      421 aacacacttg gaacacagtt tcatatttca tttctgacca ctgctgtggc aactgtaaac
      481 gacacacagt ataccgtagg ctctctggca tctgccatga gcggtcctgc catggctgtc
      541 gccatcggct atgcgctgca ttgtccgccg ttggtgttgt tctcactgat cactgttggc
      601 tttgcatcta acgcattagg cggtgcaggc ggaccattgg ctgtattatt tgttgccatc
      661 ttcgcttccg aaatcggaaa agcagtatct aaggaaacca aaattgatat tctggtcact
      721 ccacttgtca cgatcggtgt aggtgttgcc ctgtccgcat ggtgggctcc ggcacttgga
      781 agtgcagcaa tgaaagtggg aaatattatt atgtgggcaa ccaacctgca gccgttcctg
      841 atgggaatcc ttgtttctgt atttgtgggt attgcactga cacttcctat ctcatctgcc
      901 gcaatctgtg ctgcgcttgg ccttaccgga cttgccggag gagctgctgt agcaggctgc
      961 tgcgcacaga tggtaggttt cgcagtaatg tccttccgcg aaaataaatg gggtggtctt
     1021 gtttctcagg gaatcggaac atccatgctc cagatgggaa atatcgtaaa aaatccacgc
     1081 atctggattg caccgatcct tacttctgcc atcaccggac ctcttgcaac ctgtctgttc
     1141 aaacttcaga tgaacggtac tccggtttct tccggtatgg gtacctgtgg tttcgtagga
     1201 cagattggtg tctacaccgg atggatgaat gatattgccg caggaacaaa aacagctgtc
     1261 acaggctggg actgggccgg acttttgctg atttccttta tcctgcctgc aatcctgtgt
     1321 ccgctcatca acatgtttat ccgtaagctt ggatgggtga aagacgggga tatgacactt
     1381 tcataagcga aaacagctgc gttacctgtc aattgaaact gttacttgat aaaaatttca
     1441 gctaacagtt tcaatggtaa cacagctgct ttttattttt ccacttccat atattgattt
     1501 ccctgaggat cactcaaatt gtcatccaca taaacttttc atccctttgg aaatcgcctt
     1561 tcagtgataa gatttttata ttcgtacttc ttcatccatt ttaagcaatg cactcttagc
     1621 cagctgatct gcctcttcat tgtaatgatt gcccgtatga gctgctattt tacaaaaaga
     1681 aatctttact ttctttcctg cttcctgcat atgagcagca tatttgctgg tcagaggtgt
     1741 tttggctctc cacatacctg ttacccactt ctctacacct tcgtaatcat agcggatttc
     1801 cacagctgga tatttgtttt ctatggccca gtttactgca gtcatggaac caagcatctc
     1861 gcctgccaca ttccgaatgg caactcctgc agggtcactg ccacttccgg atttgcggat
     1921 ttcctgtccg tccggtgtaa ggatcacaca gccaaaagca tatctgccaa tgcttttctc
     1981 gaaacttcca tctacataag caatgaccat attttcaggt acttccacga ttcctgccgc
     2041 ctcttttgct ttatcaccag atacatttcc tgttgtctcc atgttcagaa aagccaatgc
     2101 ttcctctttc tctgtaaatc cccgaaactc agctcctgaa tatccgctta ctgccttctg
     2161 gcactccgcc catgtaacaa aaagtcctgt tttatgtccc ttgcgtactg catatatttt
     2221 cttctttgcc ataaaatcct cctgaacaat caatattttg actcacatta ctttactata
     2281 ttttgattaa tactatataa tctttctttc tatcaggcaa gttatacaat ggaaatttct
     2341 ccaaaaaaca acgtgcagat acattttaaa atcgggataa atcttcaaac ctgaagttat
     2401 ctgtcgactt caatgtttct gcacgttttt tataatagca gatattttta atcaatacct
     2461 tctgttaacc tgtagcaatt acataaaata ctgcattcct ctttatctga atttataaag
     2521 ccttatgata caattccaca atatcctgct ttctggagga tcttggattt actgcaatat
     2581 ttccgctctt catagcatca tctgccatgg catcaatctt gctttcaatc tcctcatcag
     2641 aaatctcttc tcccttcttt gcctggcgga tggctgtggt caggtcttcc gggattccga
     2701 tatcttcgtt taattccctg atggcatcca ccagcatcag cggttcgaat tcatcctcat
     2761 atgcagggat cggactgata taattataaa tcttcagata tctgccatga tctgccagcg
     2821 cattatattc tgcaatcaca gggagaagaa ctgcatttgc cactccatgt gctacattaa
     2881 agaaagcact taccggatga ctcatggcat ggacatttcc aagtcttgca aaggaaaagg
     2941 cgattcctgc aaaaagagag cctgtaagca ttgcttctgc tgcctccaga tctgtacgtc
     3001 ttgccacaaa acggcggata tttccaccga tcagctccat tgctttctct gccattgcgt
     3061 cagaaaaagg agatgctgct gtggaaacat aagcctcctc cgcatgaata aatgcatcga
     3121 ttccgcaggc tgctgccaca gatgccggag cagatgtgag aagttcagga tccaggatcg
     3181 catatgcagg aagaagttca taactgaata ccgtcagctt ataatctctg ctgtggtcag
     3241 tgataacaga aaatgccgta acctctgagc cggttcccgc agtagtcggg attgcgatca
     3301 gcggaacaat ttttccggga accttatgtg ccccctcata ttctgtaata ctgccgccat
     3361 atttagccgt aactcccact gcttttgcca catccatagg agaaccaccg cccagcgcaa
     3421 cgataaaatc tgcgccggaa tccttatacg cttctgtcgc tttttccact gtggtgacag
     3481 acggattggc ttctacatct gtaaaaatat ccactgccat tccggcgtct ttcagataat
     3541 ccgccgcctt atccacaact cccattttcc ggagagttgg tcctgagatc agcattgcat
     3601 gagatcctcc aagctttttg gcacattccg gaagcttcgc cagagtccct gcaccgactg
     3661 taatattctg aggaataaaa aattcaaatg gattcattaa tttctgcctc ttttcctgta
     3721 ttttttcaat attgcaatgt gcagggcatc taccctgcac aaattcaaaa ctctgttacc
     3781 caaaataatt gtcatgtcat ttatagcgtt atgccataga ggaaagcacc ctgtcaatag
     3841 ccgcatcgat taccacatca agctcttcat catcagcctc cggcataaga cttgctgcat
     3901 cctcatcaga gatcagttca ataagtttac caaaatcttc tttatattta cgtttacaga
     3961 tcgcataaaa tacaactcca agtaaactcc agctacctac cataagccat tcctgaaata
     4021 ccagacttcc accggaaccc ggaatacagt aaaccagaag catcagccct gacatgacta
     4081 ctgccataaa acctacaaat ttgtagtggc ctactttgta aggtcttgcc atatccggtt
     4141 cctttttacg aaggatcagg aaagagacag agaccataca gtatgcaagg cagcatccga
     4201 agttacctgc atcacagatc cagaccatca ttgttcttcc tgcaaaagga gccagcatag
     4261 tcagggcacc gatcagatac agagaattaa ccggagtttt gtgcttcgga tgaagctttg
     4321 caaaaaacgg aggaatcatg taggattctg ccatagagta catggcacgg gaaccgccaa
     4381 ggaggaagga gttccatgat gtaataatac cacacattcc acctacaatg ataaccttgg
     4441 ccataacctt tgtcccgaaa gccttggcca tggcatctgc cgttacaagt cctgttccct
     4501 gctgagactc aataatctct gccggattca ggatataacc tactgcaaga atcaccagtg
     4561 agtaaaatac aacagccagc acaacagaga ggatcatcat tttaccgatt tttttcagcg
     4621 gaacattaat ctcctctgct gcctgtggga taacatcaaa accaataaag aaaaacggag
     4681 tgataactgc aaccttaata atacttttca ttgcttcacc ggtaccgttt ccaacaaaca
     4741 tctgtccctg aaggttatcc acacttcctg taaccacaga agccacgatc agaataattc
     4801 cggcaccgcc gataatacag gtaagaacag tctgcaaaac tgctgcagtt tttgctccat
     4861 taatgttgat tatcataata agaaaagcga tcacaattgc cacgatcagc caggatgcat
     4921 aaacatcaaa gcctgcagct gtatagagat atcctttcaa gaaccccggc cacagataag
     4981 tgatgattgt gggaaatgca catgcctcaa agcaggcaac acttacatat ccaagaataa
     5041 tcgcccaggt acagataaaa gaacctgtag aacccattgc cctgtagctg aatacgtgct
     5101 caccaccaca ctgaggcata gctgctgtaa gctctgcgta agtcagacct acaaagaaaa
     5161 tcatgattcc accgattgca aatgcaatag ctgcaccaag cacaccaccg gattcaatcc
     5221 agttaccgga agaaactacc cagccccagc cgatcatggc gccaaatgca attacaagta
     5281 tgtcccatgc accaagtact ttgtcaaatt ctgatgtttt ttgttccata ggtcaggcct
     5341 ccttttttcc gtattttttt gcgatcaggt cttccagata ttctgctgtt ccctgaattc
     5401 ccagaaaatc actgttaata agaatatccc tgttatgtct gtcaccacgg ttacttcctg
     5461 tcagtgccag atgtctctta tgataacgtt tatccttctc atccagcaga agctttgcat
     5521 ccttttccga gagattatgg ctttccataa tgttgtggac gcgaacatca ttaggtgcat
     5581 aaataaatgc tctcaccagc tggattcctt ctgtatcttt cagaatataa tctgcagacc
     5641 ttccgatgat cacgcaggct tctttctgcg ccagcttccg gataatctgc ttctgtacat
     5701 gaatggcgcg gtctgtcaga tccgcatatt tggaaaagga acctctcaca tctccctgtg
     5761 cacctttacc tgcgatggtt ccgccttcct ctactctgtc cataatgtct gtagggatgc
     5821 ctacctcttt gataatctca tccacaagat cacgatcata aaacttaatc cccagatcct
     5881 gtgcaatctt cttaccgatg gcattgccct tggctccata ttcgcagcca atcgtaatta
     5941 ccagatgttt catgctcttc cctctcacac tcaaattttt atcagattct caaacattcg
     6001 aaatccgctg atttgctatg taaatcacta ctttctcatg tttggcaggt cccaagttca
     6061 aaagtcttat cgtgcaggca cgaacgactt tttgaccttt gggccctgat atcataaaag
     6121 ggcgcacgaa tataattcgt gacgcccttg tccttactgt atcactccgt tgccggattt
     6181 ttatttttcc agagatttaa ttgtatcttc gatgattgct acagctttgt cgcactcttc
     6241 ttctgtaaca ataagcggtg ggatcatacg gatgatatgc gctccgatag ctgtgatcag
     6301 aagatgtctg tcaagacaac catgttttac atccactccg ccgatagtat catcaaattc
     6361 cacacctacc agaagtccct gatgtcttac ttcttttaca tgaggaagct tctcaagctt
     6421 agctgcaaag taatcgccaa ccttctttgc atttccagcc aaatctctgt ccagaagctc
     6481 attcacctca gccagtgcag ctgcacaact taccggatgt ccgccgaatg tagttccatg
     6541 ggaacctgct gtgaaagctt ttgcaacctc tgctgttgca cagatggcac cgattggcat
     6601 tccaccgccc agagcctttg ccatagatac gatatccggt ttgataccat aattcatata
     6661 ggacataaca gcacctgttc tgcaccatcc tgtctgtact tcatcgatca gaagaagcat
     6721 atcgttctca tcacagaatt tacgaagtcc ctgcatgaat tccattgttg caggatgtac
     6781 gccaccctcg ccctgtacag gctcaaccat aatggcaatt gtgttctctg tacatgcatc
     6841 cttgaaagcc tgaaggtcat tgtacggtgc ataggagaaa ccataagtca taggtccgaa
     6901 tccaacctgg catccattac ccggctgacc tgttgcagac atggcaccaa aggttcttcc
     6961 atggaatccc atctttgcag ttacgatatg ataacggttt ggaccatatt tttcaatacc
     7021 atatttacgg gccattttga tcattgcctc gttagcctct gtaccggagt tctgatagaa
     7081 aatcttgtcc attccgattg tttcacagac tttctcagca agcagcgcct gcgggattgt
     7141 gtatggatag ttgaatgtat gcataatatc atctaactga tcctttgcag cagctacaac
     7201 cttagggtta cagtttcctg cgctgtttac tgcaatacca gcataaaaat caagatatgg
     7261 agttttattc tcatcataaa tgtacatgcc ctctgctgtc tctgcaagga aatcaaatct
     7321 ctcataagtc tcgatcatgt acttgtttac tttgtcctta atgtcctgaa aagttaatcc
     7381 tgtgtctttt aatttcatag ctgtgccctc ctgcatcctt aagataataa aaaaagcaaa
     7441 gacaaactga cccgtatggg taagcgcctt tgcttaactt tttctgtgta ttattttgta
     7501 catccttaca atatcactgc ccttatgatt tgtcaacatg tttttttgaa catttacatt
     7561 ttttacagaa agatcgttac tgaaaacgga gtgaacagta acgaaagctc tgtgttctcc
     7621 ttattgtata tccaatattt cctgcatatt cgtgcgataa taaaggtttc tcaacaattc
     7681 ataacaacac agcctcttca tgaaatggca gactgacaaa ccattacata catcctttct
     7741 tttcagatat tcattttctg gtgtatcttt ttcattattt tgtgcattat attgtacatt
     7801 ttacactcat acttcggata aaatcacctg cttcactact cagttctaca ctatggtaat
     7861 ccacctgcgg cagaccgctt cagcaacaaa actcctgata caactgcatc aatgataatc
     7921 cagaaaaaaa caggtacagc aggctttctc cttccctgtg ttccgataga catgttcctg
     7981 atccgtttca aacttaaaca cctgatctct gtggatttca tacttctcac catgacattc
     8041 cagagtaagc acaccctcca taacagccag atattctctt gtcttctccc catggctgcc
     8101 actgatataa acaccacccg gttccacctc gatccggtac acctccacca gacgggtatc
     8161 ctcataaggc agacaggtcc ataccctgta ctgtcctgct atctccttgg taggaaccag
     8221 ttctgccggt gtcaccagac aacagtccac tctcggcggc tgtatcagct cctgaaactc
     8281 tatcctcaga ccacttgtaa tcttccccag cacacccaga gaaggattgg cagtccctct
     8341 ctcaatctga gccagcatac tcttactcac ccccgtctgc tcagacacct gatccagact
     8401 catactcttg gatttccgaa tcctcttcag attcaccgcc acattattcg ataaataatc
     8461 catatgtccc ctccttccaa acaactgtat tatttatttt ttatatcagc aatatagaaa
     8521 tctgtcaatt acattactgt tcactccgtt ctcagtaacg tagccaaaat tcattcagga
     8581 acataaattt tatagcaatt atccaaaacc cggttgacaa tttcctctct ataaatgtat
     8641 aatgtaaccc aagaaaacat ttgtccaccc tattcggaca atgaatacct catatcagcc
     8701 aaatgccatg acagggagga gtacacaact ccgggaagca cagagagaaa gcggtcggtg
     8761 cgagctttcg tgaacgaatt gtggaagtag cccccgagca gtgaaccaaa ccgtatatcc
     8821 cgtctgatcc acaagacctg aacggacatg ccaagtaggc ttcaacgtca gttccacgtt
     8881 acaggaacac agtatatcag tactgacaaa gtgcagagcc agactctgaa tacaggtggt
     8941 accgcggaaa tattttcgcc ctgggcaata agcccagggc gttttttact atattcagaa
     9001 ttgtgggagc tgctttacag cgttctcagc agaatcagcg cagcgccatt ctgcccctgt
     9061 atcagccaat acacagctca gaaatttatt tgtttggtgt gcatttgcag gagtcgtgta
     9121 gatcttagtg cctggaaatc tgcgttgttc agaaaaatct cactgtctga gcgcagcgag
     9181 tttgagattt ttctgaacgc ttttagcaga ttttcagaca cttagatcta ctaggctccg
     9241 aaaccgcaca ccaaacaaat aaatttctga gcgtcctata cacatacaca aaggaggttt
     9301 acccaaatat gaaacaaata tccggcaaca aactcttagt caaagcctta aaagaagaag
     9361 gcgtagaata cctcttcggc taccccggag cctgtaccat cgacatcagt gatgaactct
     9421 acaaacagga cgatgtcaaa atcatcctcc cccgtcacga acaggccctt gtccacgaag
     9481 ccgacgccta cgccagaacc accggcaaag tcggcgtatg tctggtaacc agcggtcccg
     9541 gagcaaccaa ccttgtaaca ggacttgcaa ccgccaacta tgacagcgta cctcttgtat
     9601 gcttcaccgg ccaggtagcc cgccacctca tcggcaacga tgcattccag gaggtagaca
     9661 tcgtaggaat caccagaagc atcaccaaat acggcgttac tgtccgcaga cgtgaagacc
     9721 ttggcagaat tatcaaagaa gccttctaca ttgcccgcac cggccgtccg ggacctgtcc
     9781 ttatcgacct tccaaaggac gtaatggcag aactcggcag cgctgaatat cctaaaaatg
     9841 taaatatccg cggatacaag cccaacacag atgtccacat cggccagctc aaacgtgcca
     9901 tcaaactttt aaataaagca aaacgtccct tattcctggc aggcggcggt gtagtaatct
     9961 cccgcgccca tgaaattttc cgggaagtag tggaaaagac aaaagtaccg gttgtcacaa
    10021 ccgtaatggg aaaaggctct atccccacag accatccact ctatatcgga aaccttggca
    10081 tgcatggtgc ctatgcagca aatatggcag tcagcaactg cgatgtgctg ttctccatcg
    10141 gaaccagatt caatgacaga atcaccggaa aacttcatga atttgcacca catgcccaga
    10201 ttatccacat tgatattgat acagcatcca tttcccgaaa cattcaggta gatatcccca
    10261 ttgttgctga tgcaaaagag gctatcacca aaatgaacga atacgtccag gaatgttcaa
    10321 cggacaagtg gcttaacctg atcaaaaact ggaaagaaga gcatccgctt aaaatgcgtc
    10381 caaatgatct tttaagtccg atggatatcc tgaaagagat caacgaacaa tttgagaaca
    10441 gtattatcgt aacagatgta ggacagcatc agatgcttgt ctcccagtat gcggaaatca
    10501 cagagggcaa acagatgatc atgtccggtg gtctgggaac aatgggctat ggtcttccag
    10561 gcggcatcgg agccaaaatc ggaaatcccg acagacctgt catcgttatc tccggtgacg
    10621 gcggtgtgca gatgaacatt caggagcttg caactgcagt tctggaggag cttccggtta
    10681 tcctgtgtat ctttaacaat gagtatcttg gaatggtacg ccagtggcag aagcttttct
    10741 acggcaaacg ctatgctatg accaatctgc gcgcaggagc actttcccgc cgcactgaag
    10801 gcatggaata tccacagtac acaccggatt tcatcagact tgcagagagc tacagggcaa
    10861 aaggaatccg tgtcacaaaa aaagaggaaa ttgcagcagc cttcgaggaa gcaaaaaaga
    10921 acacaaaggc acctacagta attgaattca tcattgaccc tgaggaaatg gtttatccta
    10981 tgatcaaacc aggcggaact ctagaagata tgattatgga ctgttgatca ggaggaaaat
    11041 tattatggat aaaggaatga aaaaaagatg gatttctctc tatgttgaga accaggtagg
    11101 tgttctgtcc aaaatctccg gacttttctc cggaaaaagc tacaatctgg acagtcttac
    11161 tgtaggaacc accgaggacc ccacagtatc tcgaatgacg atcgcaactg tcagtgatga
    11221 tgaaactttt gaacagatca aaaaacagtt gaaccgtatg atcgaggtta ttaaggttat
    11281 tgatttcaca gacgtatttg tccgcatgaa agagattctg tatattaagg tttttaactg
    11341 ttccaaagaa gataaggttg aactgtttca gattgccgaa accttcaagg caaaggttat
    11401 tgactacgac aaagacagtc tgctcctgga atttgtccag acagcaacca agaatgacgc
    11461 agtagtgaaa ctgatcaagg aagaatttca cagaattgaa gtggtacgtg gaggaagtgt
    11521 aggaatcgaa tctatcagta tgatggaacg ataaaacttt ttctgaaatt tttataaagg
    11581 gaggattgtc gcattgttct taatgctcag tcctcccttt acttacggtt cttctgtctt
    11641 ttcgtttttc atctgtgctt tcgcttttcg cccaatccgt gcattgctgt tcataatact
    11701 ggcacgggtg atcttatcat ttccaaattt catccggatc tcatccatag ctgcatccag
    11761 ctttctgcgg cgttctttat tttctgtatc ttcaaacaga gacatctgtt cataagtgcc
    11821 gtctgtaagg cctgtcagcg ccacaccaat cagacgtagc ggctgtcctt tccagaattc
    11881 tttaaaaagt cttgtagcat ttatataaat ttcatctgta agatctgtag cattttccag
    11941 ctttgtctgg tgtgaacggt ttctgaaatc caaagtacgg aaagtcacgg aaatacagtt
    12001 gcatttctta tcttttctgc gcattctggt tgccagaaca tcacactgct ccaaaagtat
    12061 gggaaacacc tgctctatgg aagtaatatc atcgttaaaa gtagtttcca cactgaaacc
    12121 ttttgcctca tcaggcactg cttttacagg ggaatcatca atacctctgg catattgcca
    12181 tagctgatgt cccgtttttt ccccaagcca gtactgcaca ttggatgctc tttctcttgc
    12241 cagatcaccg atggtacgga tcccctgatt cagaagcttc tgctcggaag cttttcccag
    12301 aaacagcaga ttacggatag gaagaggcca cattttctcc gggatttcat ccgggaacag
    12361 agtgtgtact ctgtccggct tttgaaaatc tgatgccatc tttgccaaaa gcttattggt
    12421 agaaattcct acatttactg tgaatcccag ctctctgtga atcttgtctt tcagctcatg
    12481 agcagcagct acagggtcag gatagatcag agaagtacct gtcatatcca gaaatacctc
    12541 atcaatggaa aaagattcca tcacaggtgc aaaggaagca cagattgctt taaatgcccg
    12601 ggaacattta tcgtataatt caaaatcact gggaacgatc accaaattgg gacatttccg
    12661 aagagccata gctactggct cgccggtctg gatcccgtat ttttttgcag ggatagattt
    12721 ggcaaccacg atacctgtcc gtttctttgg atctcctcct acacaggaag gaatttctct
    12781 gagatccggt agcccctggc tcacccttct ggctgattcc caggaaagaa atgcactgtt
    12841 gacatcaata tgaaaaatta atcgttccgt acttttcact gttcttcctc caatatatga
    12901 attgcgctct tcatatctga tgatttcatt ttaccctgat ctgctctcca gggtaagaac
    12961 ctcgtttgtc caaaaaagtg tctttattta catcatcttg tctgagctgt tactgtattt
    13021 atatttgttt gatttcactc tgctatcaga gttttgaaca acaacgccgc acttgccata
    13081 cggcagtgcg gcgtctgtat ttcgctaccg gtcacattgt tcccggtaac tttttttact
    13141 taatgctgag gattcatttc ctctcgatat atacttatcg attagtcata aaggttagga
    13201 gcaatttctt cgctgtccat atttgtggaa tcataccagt atccagttca gcctccagcc
    13261 attcataaga gaattccggg aatgtctgat gtttgaaatt tttccatgtt actcctttct
    13321 catgaagtaa ctgtctacac ataagcaaac agtgctatcg ctgtcattga tcagcaataa
    13381 gcccccgtgt tttcatatag ttccattata ccttctcatt ttcccgaagt caacataatt
    13441 taacatgtat cagccgttta tttgtgttgc tttttatttg atttttgttg tatttcagtt
    13501 gtttttattt tgtttcctca ttgacattta aatcctcatc tgtcatactt gaatataacg
    13561 aatgtaccat caaacagcag ctttgcatct tccgtaaggc tcttatcata tatagaaacc
    13621 gctctggaaa ggagacaaac aatgtatctt tctgacatcc acacacattc tatcgccagc
    13681 ggtcacggaa ccacctgtac catctctgac atggcaaaag cagccagcaa aaaaggactg
    13741 aaactccttg ggatttctga ccacggcccg ggaactctgg cttccggaac ttcttcttat
    13801 ttcagaagcc ttccttttta tcccagaaaa agattcggca tagatattct ttacggagtt
    13861 gaactaaaca tcctggacag tgcaggacat acagatctgt cagatgaact gctgaacaac
    13921 ctggattacg ctatcatcag tatgcatcgg cagaactacc gttcaggctc tgtatctcag
    13981 aatacagaag cttacatcaa tgcaataaaa catcctgctg taaaaatact cggccactgc
    14041 gacgatacac atttccctgt agattatgaa acgctggcaa gagcagcttt acgggaaaat
    14101 gttatttttg aaataaacga agcttccctc gcacccggag gatatcgggg agacacaaga
    14161 gccaatgcag ccagaatcct gtatctctgt cagaaatatc agcttcctgt tattttgtcc
    14221 agcgacagcc acggaaaaga acatgttgga gatttcacct atgccgaaga attcgttcac
    14281 cagctcatgt ttccggaaac tcttatcctt aacaaccagc ttcccaaatt aaaagttttc
    14341 cttcagacac gttaaaagaa tgttcctcaa agggacattc ttttatttta tgcattgttt
    14401 tttgcattgt gttattttgt ttattttcta taatttcttg tcaaaaaaga cgacatttta
    14461 gtacatttta attaacaaaa ctcacttaac catttacata tctcgtgata gatcagtctt
    14521 actgtaggaa ccaccgagga tcctacagta tcccgaatga ctatcgcaac agtcagcgat
    14581 gatgaaacct ttgaacagat caaaaaatag ttaaaccgca tgatcgaggt tatcaaggta
    14641 atcgacttca cagatgtatt tgtcagaatg aaagaaattc tctacatcaa ggttttcaac
    14701 tgctccaggg aagataaagc agaactgttt cagattgcag aaaccttcca ggcaaaagtc
    14761 attgactacg gcaaagacag cctgcttctg gaatttgtcc agacagccac caagaatgat
    14821 gcagttgtca aactgatcaa ggaagaattc cacagaattg aagtggtaca tggtggaagt
    14881 gtgggaattg aatccatcag catgatggaa cgctaaatct cataatcaat atttttttac
    14941 aggatataga aacacctcta tatcgttact gttcactccg ttcacagtaa cgtagccaaa
    15001 attcattcca gattgcctgc ggcaatggaa ttttggcttg tatgtctcgg gattttggca
    15061 tattcatgcc aaaacacctc gcggaatagt ggtgtgtgaa cagtaactc
//
