LOCUS       gnlProkkaGAGFMGDE_109  13781 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GAGFMGDE_109.
ACCESSION   gnlProkkaGAGFMGDE_109
VERSION     gnlProkkaGAGFMGDE_109
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:06:51
            Original ID  :: gnl|Prokka|GAGFMGDE_109
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13781
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..156
                     /locus_tag="ctg109_1"
                     /transl_table=11
                     /translation="MEDCRKSKICVIIHSIKMKKNITEYLQNDKSLIIYRYVILLYYVK
                     RELIFG"
     protocluster    1..13781
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2192:3781]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2193..3781
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13781
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13781
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             214..1719
                     /locus_tag="ctg109_2"
                     /transl_table=11
                     /translation="MSNNIRIRKKKLKGTGIFAAAALTAALIAGNNIPGVTRQVSAAES
                     QENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEG
                     QDLSHVDGWDPESGAVVGYINVIVNSITDGDNVDKTEGSGKTDPTENADPTETPETSSE
                     KPAADENADTDNKEDKESKSDQDNKTDTDNEESKIEEDKTDNKNNKDNNSNADKTDKDT
                     ETTGKLEPADDMTQDKEDTKKDDEDGADDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEE
                     RAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEY
                     EIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSR
                     QLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSMNDSSDSNNGSSSDQNDNSTE
                     NKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVVVFIKKRKK"
     CDS             1769..2119
                     /locus_tag="ctg109_3"
                     /transl_table=11
                     /translation="MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIII
                     YVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSIMAKGGWDMSAAHAVTTFFM
                     CTGGGTLGGMLS"
     CDS             2193..2333
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_4"
                     /sec_met_domain="TIGR03973 (E-value: 1.1e-27, bitscore:
                     87.3, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.4e-27, bitscore: 87.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQ
                     K"
     CDS             2414..3781
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_5"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 5.5e-29,
                     bitscore: 92.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.8e-16, bitscore: 51.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.3e-14, bitscore: 45.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.3e-20, bitscore:
                     62.7, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEA
                     IAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIA
                     HDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNW
                     QVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHD
                     YMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQI
                     SVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCV
                     YKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYT
                     KKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD"
     CDS             3893..6301
                     /locus_tag="ctg109_6"
                     /transl_table=11
                     /translation="MKKSKGIVVLLLTLILTVFFCFTAAVGIGPTGTGAAKHINTGLDL
                     AGGVSITYQAKESNPTSEEMSDTIYKLQKRVEQYSTEAQVYQEGSDRITVEIPGVTDAD
                     TILNDLGKPGSLYFITKEDADGNQNFTTGQDGYVLSRTMDEIKESGSVVLEGSDVADAQ
                     GGAIQNQNTSAKEYVVSLTLTSDGENSGKTKFAEATKNNVGKQIAIVYDNNIISAPNVN
                     EEISGGKAQISGMSDLEEAQNLASYIRIGSLGLELEELRSSVVAAQLGEEAISTSVLAG
                     AIGLIIVIIFMIIAYRVPGVVAGIALILYTSLMLITLNAFDITLTLPGIAGIILGIGMA
                     VDANVIIYARIREEIGAGVSVRNSIKSGFSKAFSAIFDGNITTLIAAFVLMWLGSGTVK
                     GFAYTLALGIVISMFTALVVSRLIVNALYAVGVRDPKFYGSAKERKAVDFLGKKKVFFA
                     ISIILILCGPAAMFANSHAGNKALNYSLEFSGGTSTTVTFNEDMDIKTIDSEVTPVVEE
                     VTGDKNVQPTKVVGTNQVVIKTRSLNQSEREALQSALVEKFGVDDSTISTESISSTVSS
                     EMRRDAIVAVIVATICMLLYIWFRFKDIRFASSAVLALLHDVLVVLAFYAIARVSVGNT
                     FIACMLTIVGYSINATIVIFDRIRENLHSGSREKLAEIVNTSITQTLTRSIYTSFTTFV
                     MVAVLYIMGVSSIREFAAPLMVGVLVGAYSSVCITGALWYVMKKKFAGKGQPAIAAASA
                     SAKSSSKPKKARDVSQKDPTQPKKKNRKRVAERLAAEEAAKKQQNDDAE"
     CDS             6383..8095
                     /locus_tag="ctg109_7"
                     /transl_table=11
                     /translation="MEKWVIAAKRADFNQIGQQFHIDPVIARLIRNRDVIGEDKIREYL
                     SGTVQELPSPWLMKDMEKAVDILEKKISQKAKVRIIGDYDIDGVTSTYILMKGLARIGA
                     DVDTYIPDRVADGYGIHAHLIERAETDRIDTIVTCDNGIAAAAEIQMAKDKGMTVIITD
                     HHEVPYREEKGERQMVLPPADAILNPKQYDCPYPNKNLCGAVVAFKYIAALYERFGVPA
                     EELEDYYELAAIATVGDVMDLQGENRILVKEGLCRLKNTKNQGLQELIRANSLEDAKIT
                     AYHIGFVLGPCINASGRLDTAARSLALLNAKTKEEAARLAGDLTALNQSRKALTEKGKE
                     EAIRIIETTELKNDRVLVVYLPDCHESLAGIIAGRIREKYHRPAFVLTGGETSAKGSGR
                     SIESYSMYEELVKCADLMIQFGGHPMAAGLSIEEKNIEEFRRRLNVNCTLTDEELRPKI
                     VIDVPMPVSYITKELVEQISLLEPFGKGNTKPVFAQKNLRVLDHSIIGKNKNVVKLKLL
                     DPQGISVEGIYFGEAEDFVNFIREKDIISVTYYPEINRFRGRESLQIIIQNYC"
     CDS             8243..8767
                     /locus_tag="ctg109_8"
                     /transl_table=11
                     /translation="MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCL
                     KDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEM
                     HKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGY
                     DVASVICYDGK"
     CDS             8805..11135
                     /locus_tag="ctg109_9"
                     /transl_table=11
                     /translation="MTEITKSTEAKKDEMQVEKEKLESVKRADAAVKTMHDFTSPEVLY
                     KELINSVLKYHPSTDISMIEKAYKVASEAHEGQKRKSGEPYIIHPLCVAIILADLELDK
                     ETIVAGLLHDAVEDTWMTYEEVEKEFGSEVALLVDGVTKLGQLSYSADKVEVQAENLRK
                     MFLAMAKDIRVILIKLADRLHNMRTLQYMRPEKQQEKARETMDIYAPIAMRLGISKIKV
                     ELDDLSLKYLKPDVYYDLVHKVALRKSEREQFVGAIVKEVKKHMDDANIKAQVDGRVKH
                     FFSIYKKMVNQDKTIDQIYDLFAVRILVDTVKDCYAALGVIHEMYKPIPGRFKDYIAMP
                     KPNMYQSLHTTLIGPNGQPFEIQIRTYEMHRTAEYGIAAHWKYKESSDGKAPVGKSEEE
                     KLNWLRQILEWQRDMSDNKEFMSLLKNDLDLFADSVYCFTPQGDVKTLPSGSTPVDFAY
                     SVHSAVGNKMVGARVNGKLVPIEYEIKNGDRIEIITSQNSQGPSRDWLKLVKSTQAKNK
                     INQWFKKELKEDNILKGKEMLAQYARAKGFKIANYTKTQYLEAVLRKYGFRDWDSVLAA
                     IGHGGLKEGQVFNKLVEAYDKENKKNLTDEQVLEAASETQEKLHIAKSKSGIVVKGIHD
                     VAVRFSKCCNPIPGDEIVGFVTRGRGITIHRTDCVNVLNMSETDRTRLIEAEWQQPDTK
                     EKEKYMAEIQVYANNRTGLLVDLSKIFTERKIDLRSINSRTSKQEKATISMSFEIGSKE
                     ELRSLIEKIRQVESVIDVERTTG"
     CDS             11200..11829
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     163.1; E-value: 9.6e-50)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_10"
                     /transl_table=11
                     /translation="MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCPEKIEMKI
                     SRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGC
                     SIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTD
                     FPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV"
     CDS             11822..13336
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_11"
                     /sec_met_domain="PF04055 (E-value: 1.9e-24, bitscore: 78.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCKIGILFKNRDFEHDVYELIKAFYPEAEIHTLYENGEAEYDLRF
                     SVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIK
                     YALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTAL
                     AITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALC
                     REVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRP
                     DSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNIN
                     MDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQ
                     EIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALG
                     AGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL"
ORIGIN
        1 aaagaggact gtcgaaaaag taagatttgt gttataattc actcgattaa aatgaaaaaa
       61 aacattacag aatatttaca aaatgataaa agtttgataa tatacagata tgtaatatta
      121 ttgtattacg taaaaagaga actgatattt ggctgaaagt aaaaaatgat tatcaggaaa
      181 cataagaatc gaatataaat atagaggtgc gatatgtcca ataatataag aataagaaaa
      241 aagaaattaa aaggaacggg tatttttgcg gcagcggctt taacagcggc tttgattgca
      301 ggaaataata taccgggtgt aacaagacag gtcagtgcgg ctgagtcaca ggagaatact
      361 gtgtcttctc tgattccgga caacatcacg cttgataagc cagtagaact tgcggatgta
      421 gaacttccgg caacggaata tggaactttt gaatgggcag atggaagttt cgttcctgca
      481 cagcgtgtac agagctgtga ggtacttctt ataccggcag aagggcagga tttaagccat
      541 gtggatggat gggatccgga gagcggcgcg gttgtcggtt acatcaatgt aatagtgaac
      601 agtattacgg atggtgataa tgttgataag acagaaggct caggtaaaac agatccaaca
      661 gaaaatgcag atccaacaga aacgcctgaa acttcgtcag aaaaacctgc cgcagatgaa
      721 aacgctgata cagacaataa agaagataag gaaagtaaat cagatcagga taataaaact
      781 gatacagaca atgaagagag taagattgaa gaagataaaa cagataataa aaacaacaaa
      841 gataataaca gcaatgcaga taagacggat aaagatacag aaactaccgg taagctggaa
      901 cctgcagatg atatgacaca ggataaagaa gatacgaaga aagatgatga agatggcgca
      961 gatgataata tctttgataa tcctgttctg ccggacgata aggatgaccg tcctacagat
     1021 gcagaggatt ctctttctga tgaagaaaaa gaagagaggg ccgcacttaa tcatacctgc
     1081 gacggtatta cagtaagcgg agttaatctt ccatggtatg tacagttcag agtttcaagc
     1141 ggtgacagct atcagtttac caatgaatca gatgcaatga ttttccagtc ttatgaattt
     1201 gaactctggg atcttaagaa taatacagaa tatgagatcc ctaatggaga ttatatcagt
     1261 gtcactgtgc cggtaaaatc cggatatcag tatactatcg aacatctcct ggacaacggg
     1321 gcaactgaga cgattattcc gagtgtagag aatggtatta tggtattcag cacacattct
     1381 ttcagtccat ttggaattgc aggaagcaga caattagtag gacctgatgc ggggaatgat
     1441 acggacgaca cagatgcggt aactcctgca ccggcttcct ccgacagtca gagctctgat
     1501 tccggaaaga acaatacagt atctatgaat gacagttctg acagcaataa tggttcttct
     1561 tctgatcaga atgataattc aacggaaaat aaagctgtga aaaataacaa tacagtaaat
     1621 accggagata caacatcaat tatgccgttt gtgatactgt ttgtggcagc tgcagtgatc
     1681 gccggtgtgg ttgtatttat aaaaaagaga aagaaataaa agaataacac tgattcctcc
     1741 cccatatagt ttaacaggag gggaagcaat gaaagtcaga gcaattttga aatcactatt
     1801 atttgcatat gcattaacag gagtggcatt actgcttttg gccctggtac tgtttgcttt
     1861 tgatctggga gaaacagctg tagatgcggg tattattata atttatgtac ttgcatgttt
     1921 catgggaggc tttatggccg gcaaaattgt gcgtaaagac aaatatctgt ggggtgttat
     1981 cacaggtctg gcttactatg tattactgtt gactgtctct attatggcaa aaggcggctg
     2041 ggatatgagt gcagcgcatg cagttacaac attttttatg tgcacaggcg gtggaacact
     2101 gggtggaatg ctgtcgtaaa aaaaagcttt taaaatgaaa agatatatga tatactatgc
     2161 caagaatata attacataag gaggatagag ttatggaaca tatcaaaacc ctgaatacaa
     2221 agaatttaca gaacactgta aaaaaaggtg gatgtggcga gtgccagact tcctgccagt
     2281 ccgcatgtaa aacttcctgt acagtaggaa accagagctg cgagcagaaa taagatcagc
     2341 tatggagaaa tgagataagc agcggaactt ttattccgct gcttatctta cgcttagaaa
     2401 ggattttagt aaaatgagtc tgattcaccg ttataaaagc aatggcttta atattgtact
     2461 ggatatcaac agtggatgca tccatctggt agatgaggtt acatatgagg ttcttccata
     2521 tctggaagag ggccttggca cagaagctat tgcagagaaa ctggaaaaca aatataacag
     2581 agaagatatt gagacatctg taagagaatg taataagctg aaagaagatg gaatgctttt
     2641 tacaaaagat gtttatgaga atgtaattga agaattttca aataaccggc agaccgttgt
     2701 aaaagcattg tgcctgcaca ttgctcatga ctgcaatctg gcctgccgtt attgttttgc
     2761 cgaagaaggc gaatatcatg gcagaagagc tcttatgtcc tatgaagtcg gcaaaaaagc
     2821 tcttgatttc ctgatcgcga actccggttc cagaaaaaac ctggaagtag atttctttgg
     2881 cggcgagccg ctgatgaact ggcaggttgt aaaagatctg gtaaaatatg gcagagagca
     2941 ggaaaagctt cacaataaga aattccgttt cactttaaca acaaacggag ttcttctgaa
     3001 tgatgaagta atggaattct gcaataaaga gatgggcaac gttgtactga gtgtggacgg
     3061 acgtaaggaa gtacatgatt acatgcgtcc attcagaaaa ggtgcaggaa gctatgacct
     3121 gatcatgccg aagttccaga agtttgcaga atccagaaat caggacaagt attatgtaag
     3181 aggtactttt acccaccata atcttgattt ctccaaggat gtgcttcatc tggcagatct
     3241 tggattcaaa cagatttctg tagagcctgt agttgcggct gatacggagg aatatgcgat
     3301 ccgcgaggag gatatccccc agatcatgga agagtatgat actcttgcaa aagaaatgat
     3361 taaaagagag aaagagggaa aaggatttaa cttcttccat tttatgatcg accttacagg
     3421 tggcccttgt gtatacaaga gactgtcagg ctgcggttca ggaacagagt acctggctgt
     3481 aacaccctgg ggtgattttt acccatgtca ccagtttgtt ggtgaagaac agtatctcat
     3541 gggaaatgta gacgaaggca tcacaaagcc ggaaatccag aaggaattcg gcggatgcaa
     3601 cgtttacaca aagaaagact gcaaagactg cttcgcacgt ttctactgta gtggcggatg
     3661 tgcggcaaat gcattccatt tccagggaga tatcaaaggc aattatgaaa tcggatgcga
     3721 actccagaga aaacgtgtgg agtgcgccat catgataaaa gccgcactgg catgtgatta
     3781 gtgggcagta atctgtctga ctgataccgc cgtcggctgt tatcataaca gaaaatggct
     3841 ggcaggcgga tgaacatgac cgcggacaaa aaatcaagaa gggaaaagaa ctatgaagaa
     3901 aagtaaagga atcgtagtgc tgcttctgac actgatcctg actgtgttct tttgctttac
     3961 tgcagccgta ggtatcggtc ctaccggaac cggtgcagca aaacatatca acacgggtct
     4021 tgatcttgcc ggtggtgtca gcattaccta ccaggctaag gagagcaatc cgacaagcga
     4081 agagatgtca gatacgatct acaagcttca gaagcgtgta gagcagtaca gtactgaggc
     4141 tcaggtatac caggaaggat cagaccgtat tacagttgaa attcctggtg ttacagatgc
     4201 agatactatt ttgaatgatc tgggtaaacc aggttccctg tatttcatca caaaagaaga
     4261 tgctgacgga aaccagaact ttactacagg acaggatgga tatgttctct ccagaactat
     4321 ggatgagatc aaggaatccg gaagtgttgt tctggaaggt tctgatgtag cagatgccca
     4381 gggtggtgcg atccagaatc agaacacaag tgcaaaggaa tatgtggtaa gtcttactct
     4441 tacttctgat ggagaaaaca gtggtaaaac aaaatttgca gaagctacaa agaataatgt
     4501 aggcaagcag atcgctatcg tctatgacaa taacattatc agtgctccga atgtaaatga
     4561 agagatttcc ggcggaaaag cacagatcag cggaatgtct gacctggaag aagcacagaa
     4621 ccttgcttct tatatccgta tcggttctct gggactggaa ctggaagaac ttcgttccag
     4681 tgttgtagct gcacagcttg gtgaagaagc aatctctaca agtgttcttg caggtgcgat
     4741 cggtctgatc atcgttatta tctttatgat cattgcatac cgcgtacctg gtgtagttgc
     4801 aggtatcgca ctgattcttt atacatcatt aatgctgatc acgctgaatg cctttgatat
     4861 tactcttact cttccgggta ttgcgggtat tattcttggt atcggtatgg cggtggatgc
     4921 caatgttatt atttatgccc gaatcagaga ggaaattggt gcaggagttt cagtaaggaa
     4981 ttctattaag tccggtttca gcaaagcttt ctctgcaatc tttgatggaa atattacaac
     5041 actgatcgca gcctttgtgc tgatgtggct tggttcaggt actgttaagg gatttgctta
     5101 tacacttgcc cttggtatcg tgatctccat gtttacagca ctggttgtat ccagactgat
     5161 tgtaaatgca ctttatgcag ttggtgtacg tgatccgaaa ttctacggat ctgcaaaaga
     5221 acgtaaggca gttgatttcc ttggaaagaa gaaagtattt tttgctattt ccattatcct
     5281 gatcctctgc ggtccggcag cgatgtttgc taattcgcat gcaggaaaca aagcgttaaa
     5341 ttacagcctt gagttctcag gcggtacttc tacgactgtt acatttaatg aagatatgga
     5401 tattaagacc attgattctg aagtaactcc tgttgtagaa gaggtgacag gagataaaaa
     5461 tgttcagcct acaaaggtag tcggaacaaa tcaggttgtg atcaagacac gttctctgaa
     5521 tcagagcgaa cgtgaagctc tgcagagtgc actggttgag aaatttggtg tagatgacag
     5581 cacgatttcc acagaaagta tttcttctac agtaagtagt gaaatgcgtc gtgatgcgat
     5641 cgtagccgtt atagtagcta caatctgtat gcttctttat atctggttca gatttaaaga
     5701 catccgtttt gcaagcagtg cggtattggc gcttctgcat gatgttctgg ttgtacttgc
     5761 attctatgct attgccagag tatctgtcgg taatacattt attgcctgca tgcttacaat
     5821 cgtaggttat tctatcaatg ctacaatcgt tatttttgac cgtatacgtg agaaccttca
     5881 cagtggttcc agagaaaaac tggcagaaat tgtaaacaca agtatcactc agactcttac
     5941 aagaagtatt tatacctctt ttacaacttt tgttatggta gctgttcttt atatcatggg
     6001 tgtttcttct atccgtgaat ttgcagcacc tctgatggtt ggtgttcttg tcggtgcata
     6061 ttcttctgta tgtattacag gtgcgttgtg gtatgtgatg aaaaagaaat ttgcaggaaa
     6121 aggacagccg gcaattgctg cagcttccgc atctgcaaag tcctcttcaa agccgaagaa
     6181 agcacgtgat gtatcacaga aagatccgac tcagccaaag aagaaaaaca gaaaaagagt
     6241 agctgaacgt ctggctgccg aagaagcagc taaaaaacag cagaatgatg atgctgaata
     6301 aaacaataat tgtctgaaaa acaggcagac agaaatatcc cggggtaaaa ctccgggata
     6361 tttttatgag gagagaaaat atatggagaa atgggtaata gcagcaaaaa gagcagattt
     6421 taaccagatc ggtcaacagt ttcatattga tccggtgatt gcgagactga tcaggaacag
     6481 agatgtgatc ggagaagata agataagaga gtatctgtca ggaacagtac aagagcttcc
     6541 ttctccctgg ctgatgaagg atatggaaaa agctgtagat atcctggaga aaaaaatatc
     6601 gcagaaagca aaagtccgta ttattggtga ttatgatatt gatggtgtga cctctacata
     6661 cattttaatg aaaggccttg cgaggatcgg agcagatgtg gatacttata ttccggacag
     6721 agttgcagac ggatatggga ttcatgcaca tcttatagaa agagcggaaa cggaccggat
     6781 cgatacgatc gtgacctgtg ataatggaat tgctgcggct gctgaaatcc agatggcaaa
     6841 ggataaggga atgacagtga ttattacaga tcatcatgag gttccttaca gggaggaaaa
     6901 gggagaacgc cagatggtgc ttccgccggc agatgcgatt ttgaatccga aacaatatga
     6961 ttgtccatac ccgaataaaa acctgtgtgg ggcagtggtg gcctttaaat atattgcagc
     7021 actttacgag agatttggtg ttccggcaga ggagctggaa gattattatg aactggcggc
     7081 tattgcaaca gtaggagatg ttatggatct tcagggagag aacaggattc tggtaaaaga
     7141 agggctgtgc cgtctgaaaa ataccaaaaa tcaaggattg caggaactga tccgagcaaa
     7201 ttctctggaa gatgctaaaa tcacagctta tcatatcgga tttgtgctgg gaccatgtat
     7261 caatgccagt ggcagactgg atacagctgc ccgttctctt gcacttctca atgcaaaaac
     7321 aaaggaagaa gcagcaaggc ttgccggaga tcttacagct cttaatcaga gccgaaaagc
     7381 tctcactgag aaaggaaaag aagaggcaat ccggattata gagactacag agctgaaaaa
     7441 tgacagagta ctggtagttt atcttccgga ttgtcatgaa agtcttgccg gtattatagc
     7501 aggcaggatc agggaaaaat atcacaggcc ggcctttgta ttgacgggcg gtgagacaag
     7561 tgcaaaagga agcggaagat caatagaaag ttactctatg tatgaagaac tggtaaaatg
     7621 tgcagacctg atgatacagt ttggaggtca tccgatggca gcaggtctgt ctatagaaga
     7681 aaaaaatata gaagaattcc ggagacgcct caatgtcaac tgtacgttga cggacgaaga
     7741 attgcgtcct aagatcgtga ttgatgtgcc gatgcctgtg tcttatatta caaaagaact
     7801 ggtagaacag atttcgcttc tggaaccctt tggaaaaggg aatacaaaac cggtctttgc
     7861 gcagaaaaat ctcagagtgc ttgatcacag tattatcggg aaaaataaaa atgtagtaaa
     7921 actaaaactt ctcgatccgc aggggatttc agtggaaggc atttatttcg gagaagcaga
     7981 ggattttgtg aactttatca gggaaaaaga cattatttct gttacttatt atccggagat
     8041 caacagattc aggggacgag agagtcttca gattattatt cagaattact gttaatatta
     8101 ccgcttggtt tgtaaccgcc ggtaagcctg gaaatacaaa tgtcagggct taacagtaac
     8161 ttgattctga aataaaaagg tgatatacta taaaatattt atgagcgaac agcaatataa
     8221 cacacactgg aggagaaata aaatgaagaa aattgaagat tatgtattaa gtataccgga
     8281 ttttcctgaa ccggggatta ttttcagaga tattacaagt gttctgcagg acgcggatgg
     8341 cctgcagttg gcaatcgact ccatgcagga ctgtcttaag gatatagatg tggacgtgat
     8401 tgcaggaaca gagtccagag gctttatctt tggtgtaccg atcgcatata atcttcataa
     8461 accatttgta ccgattcgta aaaaaggtaa acttccccgc gaaacagtat ctgtaagcta
     8521 tgatctggaa tatggcagtg cagagattga aatgcataaa gattccataa aaccaggtca
     8581 gaaagtggtt atcgttgatg atctgatcgc aacaggcggt acgatcgaag cagcgatcaa
     8641 gctggtggaa cagcttggcg gtgaggttgt caaggttgta tttctcatgg aacttgcagg
     8701 tttaaaggga cgcgaaagac tgaatgggta tgatgtagcg tctgtaattt gttatgatgg
     8761 taaataagca cagctgattg tgcaggacag gcaggtggga gcatatgaca gagataacaa
     8821 aaagtacaga agcaaaaaaa gatgaaatgc aggttgaaaa agagaagctg gaatctgtaa
     8881 agagagcaga tgcggcagta aagaccatgc atgattttac aagtccggag gtgctttata
     8941 aagaactgat aaacagtgtt ctgaagtatc atccatcaac agatatttcc atgatagaga
     9001 aggcatataa ggttgcaagt gaagctcatg aaggacagaa gagaaagtct ggagagccat
     9061 atatcattca tcctttgtgt gttgccatca ttctggcaga tctggaactt gacaaagaaa
     9121 cgatagttgc aggtcttctt catgatgcag ttgaagatac ctggatgacc tatgaggaag
     9181 ttgagaagga atttggttca gaggttgcac ttcttgtgga tggtgttacc aagctgggac
     9241 agttatctta ttctgcggat aaagtagaag ttcaggcaga gaacctcaga aagatgtttc
     9301 ttgccatggc taaggatatc agagttattc tgatcaagct tgcagaccgt cttcataata
     9361 tgcgtacctt acagtatatg cgtcctgaaa agcagcagga aaaggccaga gagaccatgg
     9421 atatttatgc tcctattgcc atgcgtctgg gtatttccaa gataaaggta gagctggatg
     9481 acctgtcgct gaaatacctt aagccggatg tatattatga cctggtgcat aaggttgccc
     9541 tgcgtaaaag cgagagagaa cagtttgtag gtgcgattgt aaaagaagtt aagaaacata
     9601 tggatgatgc caatattaag gcgcaggtgg acggacgtgt aaaacacttt ttcagcatct
     9661 acaagaagat ggtaaatcag gataagacta ttgatcagat ttatgattta tttgctgtcc
     9721 gtattcttgt agatacagtg aaggattgtt atgctgccct tggtgtgatc catgagatgt
     9781 ataagccaat tccgggacgg tttaaagatt atattgccat gccgaaaccc aatatgtatc
     9841 agtcattgca taccacattg atcggaccca acggacagcc ctttgaaatc cagatccgta
     9901 cttatgaaat gcacagaact gcagaatatg gtatcgctgc acactggaaa tataaggagt
     9961 cgtctgacgg aaaggctcct gtaggtaaga gtgaggaaga gaaactgaac tggctgcgtc
    10021 agattctgga atggcagaga gacatgtctg ataacaaaga attcatgagt cttctgaaga
    10081 atgacctgga tctttttgcg gacagtgttt actgtttcac tccacaggga gatgttaaaa
    10141 cacttccaag cggttctaca ccggtggatt ttgcgtacag tgttcacagt gcagtcggaa
    10201 ataagatggt aggtgccaga gttaacggta agctggttcc gattgaatat gagatcaaaa
    10261 acggcgaccg tattgaaatc attacttcac agaattctca gggaccaagc cgcgactggt
    10321 tgaaactggt taagagtact caggcaaaga acaagattaa ccagtggttc aagaaggaat
    10381 taaaagaaga taatatcctt aagggcaagg agatgcttgc gcagtatgcg cgtgcaaagg
    10441 gatttaagat cgcaaattat acaaaaaccc agtatctgga ggctgttttg cgtaaatatg
    10501 gtttcaggga ctgggattca gtacttgctg caattggtca tggcggattg aaagaaggtc
    10561 aggttttcaa taagctggta gaggcttatg ataaggaaaa taagaagaat ctgacagatg
    10621 agcaggttct tgaggctgct tctgagacac aggagaagct tcacattgcc aagagcaaga
    10681 gtggaattgt ggtaaaagga atccatgatg tggcagtccg tttttccaag tgctgtaatc
    10741 cgatcccggg tgacgagatt gtaggctttg ttacaagagg acgtggaatc acaatccatc
    10801 gtacagattg cgtcaatgtg ctgaatatgt ctgagacgga caggacacga ttgatcgagg
    10861 cggaatggca gcagcctgat accaaggaaa aagagaagta tatggctgag attcaggttt
    10921 atgcaaataa ccgtacaggg cttcttgtgg atctttctaa aatatttaca gaacgtaaga
    10981 tcgacctgcg aagtatcaac agccgtacaa gcaagcagga gaaggcaact atttccatga
    11041 gttttgagat tggaagcaaa gaggaactgc gttccctgat cgagaagatc cgtcaggtag
    11101 agagtgtcat tgacgtagag agaactacag gctgatcatg gaaaaatctg ctggaacatt
    11161 attttatgga actgctgcag attgacagaa aggaataaca tgaagaattt agaattacag
    11221 aaatgtatat taggacctgt atatacaaat tgctatctcc ttaagaataa agaaaccgga
    11281 gaactgatca ttgttgatcc cgcagattgt ccggagaaga ttgaaatgaa gatttcccgg
    11341 atgaatggaa aaccggtggc gattcttctt acccatggac attttgacca cattctggct
    11401 gcacaggcag taaaggagaa atataatatt ccgatttatg cctgtcgtca ggaagaggag
    11461 atgctccgcg aaccttcgat caatatgact gtacattatg gacagggatg ttctattgtg
    11521 ccggatgtat ttctggagga tctggatgtt atcagactgg cgggattttc cgttcagatg
    11581 atccatacac cgggacatac caaaggaagc tgctgttatt atctgaaaga tgaaggtgta
    11641 ttgttcagcg gtgatacagt gttctatggc tctgttggaa gaacggattt tccgggtgga
    11701 agtacagcag aaattgtgag aagtctccat aaactggtag attcgcttcc tgaagagacc
    11761 gaggttttcc ccggacatga tgcatctacc actattggtt atgaaaagag gtataatcca
    11821 tttgtgtaaa ataggcattc tgtttaagaa cagagatttt gaacatgatg tttatgaact
    11881 gatcaaagcg ttttatcccg aagcggagat acatactctt tatgaaaatg gtgaagcaga
    11941 gtatgacctc cgcttcagtg tggaacggga taatgacagt tatatcataa aatacgaaag
    12001 gacagagaat ctgtcgaaac aggaaacaga gcaaaaaggg gtaatttccg cagacatact
    12061 ttctaaagag aatgcaggct gtggaataca ggatgctcat gctctgagaa aagagaataa
    12121 agataatatc aaatatgctc tgtatcagtt gttggtaaaa ctgacgggca gaactcttcc
    12181 atggggaaat ctgacaggaa tacgtcctgc caaactggca atgggaatga tcgaatccgg
    12241 aatgaaaaat acggaagcag cccgggagat gcgtgagaga tatctggtga gtccgcagaa
    12301 aacagcgctt gccatcacta ttgcaaacag ggaaagagag attctgaagg atattgacta
    12361 tgaaaatgga tacagccttt atattggaat cccgttttgc ccaagtatct gtctgtattg
    12421 ttccttcagc tcctatccgc tgaaagtgtg ggagaagaga acagatgaat atgtggaagc
    12481 tctctgccgt gaggtaagag agactgctct tatgatgaag ggaagaaaac tggacaccat
    12541 ctatattggc ggcggtaccc cgactacact gcttccacat cagatccgta agctcctgga
    12601 tacagtggga gaagcttttg gctatgaagg actggcagag tttactgtgg aagccggcag
    12661 accggacagt attacacgtg aaaagctgat ggcgatcagg gagtatccgg taacaagaat
    12721 ttccgtaaat ccacagacta tgaatcagga aaccctggat attatcggcc gcagacatac
    12781 tgtggagcag acaaaagaag cgtttcatct ggcacgagag ctgggatacg ataacattaa
    12841 catggatctg atcgtaggac tcccgggtga ggatattcac atggtagagc ggactcttga
    12901 acaggttcgt gaactggcac cggacagtat taccgtacat tcactggcag tgaaacgtgc
    12961 agcaaggctg aatattttta aagagaaata tcaggaaatg tcttttgaga ataatcagga
    13021 gattatggat ctgaccatga aaactgcgta tgaaatggga atgggtcctt attatctgta
    13081 cagacagaag aatatgaagg gaaattttga aaatgttggc tatgcaaagg ttgacaaagc
    13141 gggaatttac aatatactga ttatggagga aaaacagcct atcatcgcac tgggggcagg
    13201 cggttcttcc aagctggtct ttgaccatgg acagagaatt gaacgtgtgg agaatgtaaa
    13261 agacgtttct aattatattt cccgcattga tgagatgatc gagagaaaac ggacagcaat
    13321 agctacctgg ctgtaggatg tggaggtaac attttggaca cagtacaaaa gacagcagca
    13381 ggttcacagc agaggatcct ggaatttgac cttgcttctg aactgcatca tggaatgctg
    13441 gtaagtaatc tggcttatgc ggttgcagag gagatgggac tgccgcatga acagtgttat
    13501 gagcttgcaa tagcaggaat gctccatgat ataggaaagc tgaagctgac aagttatatt
    13561 aacggacagg agcaggatcc tctggtgatc gaggaactga agtatgtccg gatgcattct
    13621 gcattgggat atgaggaact taaagggcag ggatattcgg attttgtatt ggagagtatc
    13681 ctgtaccatc atgagaatta tgatggtagt ggatatccgt ccaataaagc aggtgatgat
    13741 atacccatag gtgcccggat actcagagtc tgcgatgtat a
//
