LOCUS       c00157_gnlPro..        15190 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GAGFMGDE_157.
ACCESSION   c00157_gnlPro..
VERSION     c00157_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:36:58
            Original ID  :: gnl|Prokka|GAGFMGDE_157
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15190
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15190
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[189:8925]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      190..8925
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15190
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15190
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(190..486)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg157_1"
                     /sec_met_domain="ALS_ss_C (E-value: 1.4e-22, bitscore:
                     69.5, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVHGGSVGIESISMMER"
     CDS             complement(751..1464)
                     /locus_tag="ctg157_2"
                     /transl_table=11
                     /translation="MYLSDIHTHSIASGHGTTCTISDMAKAASKKGLKLLGISDHGPGT
                     LASGTSSYFRSLPFYPRKRFGIDILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQ
                     NYRSGSVSQNTEAYINAIKHPAVKILGHCDDTHFPVDYETLARAALRENVIFEINEASL
                     APGGYRGDTRANAARILYLCQKYQLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLI
                     LNNQLPKLKVFLQTR"
     CDS             2227..3483
                     /locus_tag="ctg157_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKDKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERRRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             complement(3552..4061)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg157_4"
                     /sec_met_domain="ALS_ss_C (E-value: 1e-22, bitscore: 70.0,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDK
                     VELFQIAETFKAKVIDYDKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(4079..5797)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg157_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.6e-49, bitscore:
                     155.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIRLAESYRA
                     KGIRVTKKEEIAAAFEEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             6643..7197
                     /locus_tag="ctg157_6"
                     /transl_table=11
                     /translation="MDYLSNNVAVNLKRIRKSKSMSLDQVSEQTGVSKSMLAQIERGTA
                     NPSLGVLGKITSGLRIEFQELIQPPRVDCCLVTPAELVPTKEIAGQYRVWTCLPYEDTR
                     LVEVYRIEVEPGGVYISGSHGEKTREYLAVMEGVLTLECHGEKYEIHRDQVFKFETDQE
                     HVYRNTGKEKACCTCFFLDYH"
     CDS             7708..8925
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: Beta_elim_lyase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg157_7"
                     /sec_met_domain="Beta_elim_lyase (E-value: 1.5e-08,
                     bitscore: 23.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_3 (E-value: 1.9e-110, bitscore:
                     358.9, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLKDTGLTFQDIKDKVNKYMIETYERFDFLAETAEGMYIYDENK
                     TPYLDFYAGIAVNSAGNCNPKVVAAAKDQLDDIMHTFNYPYTIPQALLAEKVCETIGMD
                     KIFYQNSGTEANEAMIKMARKYGIEKYGPNRYHIVTAKMGFHGRTFGAMSATGQPGNGC
                     QVGFGPMTYGFSYAPYNDLQAFKDACTENTIAIMVEPVQGEGGVHPATMEFMQGLRKFC
                     DENDMLLLIDEVQTGWCRTGAVMSYMNYGIKPDIVSMAKALGGGMPIGAICATAEVAKA
                     FTAGSHGTTFGGHPVSCAAALAEVNELLDRDLAGNAKKVGDYFAAKLEKLPHVKEVRHQ
                     GLLVGVEFDDTIGGVDVKHGCLDRHLLITAIGAHIIRMIPPLIVTEEECDKAVAIIEDT
                     IKSLEK"
     CDS             9153..9773
                     /locus_tag="ctg157_8"
                     /transl_table=11
                     /translation="MKHLVITIGCEYGAKGNAIGKKIAQDLGIKFYDRDLVDEIIKEVG
                     IPTDIMDRVEEGGTIAGKGAQGDVRGSFSKYADLTDRAIHVQKQIIRKLAQKEACVIIG
                     RSADYILKDTEGIQLVRAFIYAPNDVRVHNIMESHNLSEKDAKLLLDEKDKRYHKRHLA
                     LTGSNRGDRHNRDILINSDFLGIQGTAEYLEDLIAKKYGKKEA"
     CDS             9777..11297
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AA_permease_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg157_9"
                     /sec_met_domain="AA_permease_2 (E-value: 5.1e-47, bitscore:
                     150.2, seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKTSEFDKVLGAWDILVIAFGAMIGWGWVVSSGNWIESGGVLG
                     AAIAFAIGGIMIFFVGLTYAELTAAMPQCGGEHVFSYRAMGSTGSFICTWAIILGYVSV
                     ACFEACAFPTIITYLWPGFLKGYLYTAAGFDVYASWLIVAIVIAFLIMIININGAKTAA
                     VLQTVLTCIIGGAGIILIVASVVTGSVDNLQGQMFVGNGTGEAMKSIIKVAVITPFFFI
                     GFDVIPQAAEEINVPLKKIGKMMILSVVLAVVFYSLVILAVGYILNPAEIIESQQGTGL
                     VTADAMAKAFGTKVMAKVIIVGGMCGIITSWNSFLLGGSRAMYSMAESYMIPPFFAKLH
                     PKHKTPVNSLYLIGALTMLAPFAGRTMMVWICDAGNFGCCLAYCMVSVSFLILRKKEPD
                     MARPYKVGHYKFVGFMAVVMSGLMLLVYCIPGSGGSLVFQEWLMVGSWSLLGVVFYAIC
                     KRKYKEDFGKLIELISDEDAASLMPEADDEELDVVIDAAIDRVLSSMA"
     CDS             11409..12593
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     374.1; E-value: 2e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg157_10"
                     /sec_met_domain="Fe-ADH (E-value: 3.8e-115, bitscore:
                     374.1, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPFEFFIPQNITVGAGTLAKLPECAKKLGGSHAMLISGPTLRKM
                     GVVDKAADYLKDAGMAVDIFTDVEANPSVTTVEKATEAYKDSGADFIVALGGGSPMDVA
                     KAVGVTAKYGGSITEYEGAHKVPGKIVPLIAIPTTAGTGSEVTAFSVITDHSRDYKLTV
                     FSYELLPAYAILDPELLTSAPASVAAACGIDAFIHAEEAYVSTAASPFSDAMAEKAMEL
                     IGGNIRRFVARRTDLEAAEAMLTGSLFAGIAFSFARLGNVHAMSHPVSAFFNVAHGVAN
                     AVLLPVIAEYNALADHGRYLKIYNYISPIPAYEDEFEPLMLVDAIRELNEDIGIPEDLT
                     TAIRQAKKGEEISDEEIESKIDAMADDAMKSGNIAVNPRSSRKQDIVELYHKAL"
     CDS             12874..13530
                     /locus_tag="ctg157_11"
                     /transl_table=11
                     /translation="MAKKKIYAVRKGHKTGLFVTWAECQKAVSGYSGAEFRGFTEKEEA
                     LAFLNMETTGNVSGDKAKEAAGIVEVPENMVIAYVDGSFEKSIGRYAFGCVILTPDGQE
                     IRKSGSGSDPAGVAIRNVAGEMLGSMTAVNWAIENKYPAVEIRYDYEGVEKWVTGMWRA
                     KTPLTSKYAAHMQEAGKKVKISFCKIAAHTGNHYNEEADQLAKSALLKMDEEVRI"
     CDS             complement(13720..14811)
                     /locus_tag="ctg157_12"
                     /transl_table=11
                     /translation="MEKFKAFLRRKDIEISIKRYGIDALGAMAQGLFCSLLIGTIINTL
                     GTQFHISFLTTAVATVNDTQYTVGSLASAMSGPAMAVAIGYALHCPPLVLFSLITVGFA
                     SNALGGAGGPLAVLFVAIFASEIGKAVSKETKIDILVTPLVTIGVGVALSAWWAPALGS
                     AAMKVGNIIMWATNLQPFLMGILVSVFVGIALTLPISSAAICAALGLTGLAGGAAVAGC
                     CAQMVGFAVMSFRENKWGGLVSQGIGTSMLQMGNIVKNPRIWIAPILTSAITGPLATCL
                     FKLQMNGTPVSSGMGTCGFVGQIGVYTGWMNDIAAGTKTAVTGWDWAGLLLISFILPAI
                     LCPLINMFIRKLGWVKDGDMTLS"
ORIGIN
        1 tactgttcac acaccactat tccgcgaggt gttttggcat gaatatgcca aaatcccgag
       61 acatacaagc caaaattcca ttgccgcagg caatctggaa tgaattttgg ctacgttact
      121 gtgaacggag tgaacagtaa cgatatagag gtgtttctat atcctgtaaa aaaatattga
      181 ttatgagatt tagcgttcca tcatgctgat ggattcaatt cccacacttc caccatgtac
      241 cacttcaatt ctgtggaatt cttccttgat cagtttgaca actgcatcat tcttggtggc
      301 tgtctggaca aattccagaa gcaggctgtc tttgccgtag tcaatgactt ttgcctggaa
      361 ggtttctgca atctgaaaca gttctgcttt atcttccctg gagcagttga aaaccttgat
      421 gtagagaatt tctttcattc tgacaaatac atctgtgaag tcgattacct tgataacctc
      481 gatcatgcgg tttaactatt ttttgatctg ttcaaaggtt tcatcatcgc tgactgttgc
      541 gatagtcatt cgggatactg taggatcctc ggtggttcct acagtaagac tgatctatca
      601 cgagatatgt aaatggttaa gtgagttttg ttaattaaaa tgtactaaaa tgtcgtcttt
      661 tttgacaaga aattatagaa aataaacaaa ataacacaat gcaaaaaaca atgcataaaa
      721 taaaagaatg tccctttgag gaacattctt ttaacgtgtc tgaaggaaaa cttttaattt
      781 gggaagctgg ttgttaagga taagagtttc cggaaacatg agctggtgaa cgaattcttc
      841 ggcataggtg aaatctccaa catgttcttt tccgtggctg tcgctggaca aaataacagg
      901 aagctgatat ttctgacaga gatacaggat tctggctgca ttggctcttg tgtctccccg
      961 atatcctccg ggtgcgaggg aagcttcgtt tatttcaaaa ataacatttt cccgtaaagc
     1021 tgctcttgcc agcgtttcat aatctacagg gaaatgtgta tcgtcgcagt ggccgagtat
     1081 ttttacagca ggatgtttta ttgcattgat gtaagcttct gtattctgag atacagagcc
     1141 tgaacggtag ttctgccgat gcatactgat gatagcgtaa tccaggttgt tcagcagttc
     1201 atctgacaga tctgtatgtc ctgcactgtc caggatgttt agttcaactc cgtaaagaat
     1261 atctatgccg aatctttttc tgggataaaa aggaaggctt ctgaaataag aagaagttcc
     1321 ggaagccaga gttcccgggc cgtggtcaga aatcccaagg agtttcagtc cttttttgct
     1381 ggctgctttt gccatgtcag agatggtaca ggtggttccg tgaccgctgg cgatagaatg
     1441 tgtgtggatg tcagaaagat acattgtttg tctcctttcc agagcggttt ctatatatga
     1501 taagagcctt acggaagatg caaagctgct gtttgatggt acattcgtta tattcaagta
     1561 tgacagatga ggatttaaat gtcaatgagg aaacaaaata aaaacaactg aaatacaaca
     1621 aaaatcaaat aaaaagcaac acaaataaac ggctgataca tgttaaatta tgttgacttc
     1681 gggaaaatga gaaggtataa tggaactata tgaaaacacg ggggcttatt gctgatcaat
     1741 gacagcgata gcactgtttg cttatgtgta gacagttact tcatgagaaa ggagtaacat
     1801 ggaaaaattt caaacatcag acattcccgg aattctctta tgaatggctg gaggctgaac
     1861 tggatactgg tatgattcca caaatatgga cagcgaagaa attgctccta acctttatga
     1921 ctaatcgata agtatatatc gagaggaaat gaatcctcag aattaagtaa aaaaagttac
     1981 cgggaacaat gtgaccggta gcgaaataca gacgccgcac tgccgtatgg caagtgcggc
     2041 gttgttgttc aaaactctga tagcagagtg aaatcaaaca aatataaata cagtaacagc
     2101 tcagacaaga tgatgtaaat aaagacactt ttttggacaa acgaggttct taccctggag
     2161 agcagatcag ggtaaaatga aatcatcaga tatgaagagc gcaattcata tattggagga
     2221 agaacagtga aaagtacgga acgattaatt tttcatattg atgtcaacag tgcatttctt
     2281 tcctgggaat cagccagaag ggtgagccag gggctaccgg atctcagaga aattccttcc
     2341 tgtgtaggag gagatccaaa gaaacggaca ggtatcgtgg ttgccaaatc tatccctgca
     2401 aaaaaatacg ggatccagac cggcgagcca gtagctatgg ctcttcggaa atgtcccaat
     2461 ttggtgatcg ttcccagtga ttttgaatta tacgataaat gttcccgggc atttaaagca
     2521 atctgtgctt cctttgcacc tgtgatggaa tctttttcca ttgatgaggt atttctggat
     2581 atgacaggta cttctctgat ctatcctgac cctgtagctg ctgctcatga gctgaaagac
     2641 aagattcaca gagagctggg attcacagta aatgtaggaa tttctaccaa taagcttttg
     2701 gcaaagatgg catcagattt tcaaaagccg gacagagtac acactctgtt cccggatgaa
     2761 atcccggaga aaatgtggcc tcttcctatc cgtaatctgc tgtttctggg aaaagcttcc
     2821 gagcagaagc ttctgaatca ggggatccgt accatcggtg atctggcaag agaaagagca
     2881 tccaatgtgc agtactggct tggggaaaaa acgggacatc agctatggca atatgccaga
     2941 ggtattgatg attcccctgt aaaagcagtg cctgatgagg caaaaggttt cagtgtggaa
     3001 actactttta acgatgatat tacttccata gagcaggtgt ttcccatact tttggagcag
     3061 tgtgatgttc tggcaaccag aatgcgcaga aaagataaga aatgcaactg tatttccgtg
     3121 actttccgta ctttggattt cagaaaccgt tcacaccaga caaagctgga aaatgctaca
     3181 gatcttacag atgaaattta tataaatgct acaagacttt ttaaagaatt ctggaaagga
     3241 cagccgctac gtctgattgg tgtggcgctg acaggcctta cagacggcac ttatgaacag
     3301 atgtctctgt ttgaagatac agaaaataaa gaacgccgca gaaagctgga tgcagctatg
     3361 gatgagatcc ggatgaaatt tggaaatgat aagatcaccc gtgccagtat tatgaacagc
     3421 aatgcacgga ttgggcgaaa agcgaaagca cagatgaaaa acgaaaagac agaagaaccg
     3481 taagtaaagg gaggactgag cattaagaac aatgcgacaa tcctcccttt ataaaaattt
     3541 cagaaaaagt tttatcgttc catcatactg atagattcga ttcctacact tcctccacgt
     3601 accacttcaa ttctgtgaaa ttcttccttg atcagtttca ctactgcgtc attcttggtt
     3661 gctgtctgga caaattccag gagcagactg tctttgtcgt agtcaataac ctttgccttg
     3721 aaggtttcgg caatctgaaa cagttcaacc ttatcttctt tggaacagtt aaaaacctta
     3781 atatacagaa tctctttcat gcggacaaat acgtctgtga aatcaataac cttaataacc
     3841 tcgatcatac ggttcaactg ttttttgatc tgttcaaaag tttcatcatc actgacagtt
     3901 gcgatcgtca ttcgagatac tgtggggtcc tcggtggttc ctacagtaag actgtccaga
     3961 ttgtagcttt ttccggagaa aagtccggag attttggaca gaacacctac ctggttctca
     4021 acatagagag aaatccatct ttttttcatt cctttatcca taataatttt cctcctgatc
     4081 aacagtccat aatcatatct tctagagttc cgcctggttt gatcatagga taaaccattt
     4141 cctcagggtc aatgatgaat tcaattactg taggtgcctt tgtgttcttt tttgcttcct
     4201 cgaaggctgc tgcaatttcc tctttttttg tgacacggat tccttttgcc ctgtagctct
     4261 ctgcaagtct gatgaaatcc ggtgtgtact gtggatattc catgccttca gtgcggcggg
     4321 aaagtgctcc tgcgcgcaga ttggtcatag catagcgttt gccgtagaaa agcttctgcc
     4381 actggcgtac cattccaaga tactcattgt taaagataca caggataacc ggaagctcct
     4441 ccagaactgc agttgcaagc tcctgaatgt tcatctgcac accgccgtca ccggagataa
     4501 cgatgacagg tctgtcggga tttccgattt tggctccgat gccgcctgga agaccatagc
     4561 ccattgttcc cagaccaccg gacatgatca tctgtttgcc ctctgtgatt tccgcatact
     4621 gggagacaag catctgatgc tgtcctacat ctgttacgat aatactgttc tcaaattgtt
     4681 cgttgatctc tttcaggata tccatcggac ttaaaagatc atttggacgc attttaagcg
     4741 gatgctcttc tttccagttt ttgatcaggt taagccactt gtccgttgaa cattcctgga
     4801 cgtattcgtt cattttggtg atagcctctt ttgcatcagc aacaatgggg atatctacct
     4861 gaatgtttcg ggaaatggat gctgtatcaa tatcaatgtg gataatctgg gcatgtggtg
     4921 caaattcatg aagttttccg gtgattctgt cattgaatct ggttccgatg gagaacagca
     4981 catcgcagtt gctgactgcc atatttgctg cataggcacc atgcatgcca aggtttccga
     5041 tatagagtgg atggtctgtg gggatagagc cttttcccat tacggttgtg acaaccggta
     5101 cttttgtctt ttccactact tcccggaaaa tttcatgggc gcgggagatt actacaccgc
     5161 cgcctgccag gaataaggga cgttttgctt tatttaaaag tttgatggca cgtttgagct
     5221 ggccgatgtg gacatctgtg ttgggcttgt atccgcggat atttacattt ttaggatatt
     5281 cagcgctgcc gagttctgcc attacgtcct ttggaaggtc gataaggaca ggtcccggac
     5341 ggccggtgcg ggcaatgtag aaggcttctt tgataattct gccaaggtct tcacgtctgc
     5401 ggacagtaac gccgtatttg gtgatgcttc tggtgattcc tacgatgtct acctcctgga
     5461 atgcatcgtt gccgatgagg tggcgggcta cctggccggt gaagcataca agaggtacgc
     5521 tgtcatagtt ggcggttgca agtcctgtta caaggttggt tgctccggga ccgctggtta
     5581 ccagacatac gccgactttg ccggtggttc tggcgtaggc gtcggcttcg tggacaaggg
     5641 cctgttcgtg acgggggagg atgattttga catcgtcctg tttgtagagt tcatcactga
     5701 tgtcgatggt acaggctccg gggtagccga agaggtattc tacgccttct tcttttaagg
     5761 ctttgactaa gagtttgttg ccggatattt gtttcatatt tgggtaaacc tcctttgtgt
     5821 atgtgtatag gacgctcaga aatttatttg tttggtgtgc ggtttcggag cctagtagat
     5881 ctaagtgtct gaaaatctgc taaaagcgtt cagaaaaatc tcaaactcgc tgcgctcaga
     5941 cagtgagatt tttctgaaca acgcagattt ccaggcacta agatctacac gactcctgca
     6001 aatgcacacc aaacaaataa atttctgagc tgtgtattgg ctgatacagg ggcagaatgg
     6061 cgctgcgctg attctgctga gaacgctgta aagcagctcc cacaattctg aatatagtaa
     6121 aaaacgccct gggcttattg cccagggcga aaatatttcc gcggtaccac ctgtattcag
     6181 agtctggctc tgcactttgt cagtactgat atactgtgtt cctgtaacgt ggaactgacg
     6241 ttgaagccta cttggcatgt ccgttcaggt cttgtggatc agacgggata tacggtttgg
     6301 ttcactgctc gggggctact tccacaattc gttcacgaaa gctcgcaccg accgctttct
     6361 ctctgtgctt cccggagttg tgtactcctc cctgtcatgg catttggctg atatgaggta
     6421 ttcattgtcc gaatagggtg gacaaatgtt ttcttgggtt acattataca tttatagaga
     6481 ggaaattgtc aaccgggttt tggataattg ctataaaatt tatgttcctg aatgaatttt
     6541 ggctacgtta ctgagaacgg agtgaacagt aatgtaattg acagatttct atattgctga
     6601 tataaaaaat aaataataca gttgtttgga aggaggggac atatggatta tttatcgaat
     6661 aatgtggcgg tgaatctgaa gaggattcgg aaatccaaga gtatgagtct ggatcaggtg
     6721 tctgagcaga cgggggtgag taagagtatg ctggctcaga ttgagagagg gactgccaat
     6781 ccttctctgg gtgtgctggg gaagattaca agtggtctga ggatagagtt tcaggagctg
     6841 atacagccgc cgagagtgga ctgttgtctg gtgacaccgg cagaactggt tcctaccaag
     6901 gagatagcag gacagtacag ggtatggacc tgtctgcctt atgaggatac ccgtctggtg
     6961 gaggtgtacc ggatcgaggt ggaaccgggt ggtgtttata tcagtggcag ccatggggag
     7021 aagacaagag aatatctggc tgttatggag ggtgtgctta ctctggaatg tcatggtgag
     7081 aagtatgaaa tccacagaga tcaggtgttt aagtttgaaa cggatcagga acatgtctat
     7141 cggaacacag ggaaggagaa agcctgctgt acctgttttt ttctggatta tcattgatgc
     7201 agttgtatca ggagttttgt tgctgaagcg gtctgccgca ggtggattac catagtgtag
     7261 aactgagtag tgaagcaggt gattttatcc gaagtatgag tgtaaaatgt acaatataat
     7321 gcacaaaata atgaaaaaga tacaccagaa aatgaatatc tgaaaagaaa ggatgtatgt
     7381 aatggtttgt cagtctgcca tttcatgaag aggctgtgtt gttatgaatt gttgagaaac
     7441 ctttattatc gcacgaatat gcaggaaata ttggatatac aataaggaga acacagagct
     7501 ttcgttactg ttcactccgt tttcagtaac gatctttctg taaaaaatgt aaatgttcaa
     7561 aaaaacatgt tgacaaatca taagggcagt gatattgtaa ggatgtacaa aataatacac
     7621 agaaaaagtt aagcaaaggc gcttacccat acgggtcagt ttgtctttgc tttttttatt
     7681 atcttaagga tgcaggaggg cacagctatg aaattaaaag acacaggatt aacttttcag
     7741 gacattaagg acaaagtaaa caagtacatg atcgagactt atgagagatt tgatttcctt
     7801 gcagagacag cagagggcat gtacatttat gatgagaata aaactccata tcttgatttt
     7861 tatgctggta ttgcagtaaa cagcgcagga aactgtaacc ctaaggttgt agctgctgca
     7921 aaggatcagt tagatgatat tatgcataca ttcaactatc catacacaat cccgcaggcg
     7981 ctgcttgctg agaaagtctg tgaaacaatc ggaatggaca agattttcta tcagaactcc
     8041 ggtacagagg ctaacgaggc aatgatcaaa atggcccgta aatatggtat tgaaaaatat
     8101 ggtccaaacc gttatcatat cgtaactgca aagatgggat tccatggaag aacctttggt
     8161 gccatgtctg caacaggtca gccgggtaat ggatgccagg ttggattcgg acctatgact
     8221 tatggtttct cctatgcacc gtacaatgac cttcaggctt tcaaggatgc atgtacagag
     8281 aacacaattg ccattatggt tgagcctgta cagggcgagg gtggcgtaca tcctgcaaca
     8341 atggaattca tgcagggact tcgtaaattc tgtgatgaga acgatatgct tcttctgatc
     8401 gatgaagtac agacaggatg gtgcagaaca ggtgctgtta tgtcctatat gaattatggt
     8461 atcaaaccgg atatcgtatc tatggcaaag gctctgggcg gtggaatgcc aatcggtgcc
     8521 atctgtgcaa cagcagaggt tgcaaaagct ttcacagcag gttcccatgg aactacattc
     8581 ggcggacatc cggtaagttg tgcagctgca ctggctgagg tgaatgagct tctggacaga
     8641 gatttggctg gaaatgcaaa gaaggttggc gattactttg cagctaagct tgagaagctt
     8701 cctcatgtaa aagaagtaag acatcaggga cttctggtag gtgtggaatt tgatgatact
     8761 atcggcggag tggatgtaaa acatggttgt cttgacagac atcttctgat cacagctatc
     8821 ggagcgcata tcatccgtat gatcccaccg cttattgtta cagaagaaga gtgcgacaaa
     8881 gctgtagcaa tcatcgaaga tacaattaaa tctctggaaa aataaaaatc cggcaacgga
     8941 gtgatacagt aaggacaagg gcgtcacgaa ttatattcgt gcgccctttt atgatatcag
     9001 ggcccaaagg tcaaaaagtc gttcgtgcct gcacgataag acttttgaac ttgggacctg
     9061 ccaaacatga gaaagtagtg atttacatag caaatcagcg gatttcgaat gtttgagaat
     9121 ctgataaaaa tttgagtgtg agagggaaga gcatgaaaca tctggtaatt acgattggct
     9181 gcgaatatgg agccaagggc aatgccatcg gtaagaagat tgcacaggat ctggggatta
     9241 agttttatga tcgtgatctt gtggatgaga ttatcaaaga ggtaggcatc cctacagaca
     9301 ttatggacag agtagaggaa ggcggaacca tcgcaggtaa aggtgcacag ggagatgtga
     9361 gaggttcctt ttccaaatat gcggatctga cagaccgcgc cattcatgta cagaagcaga
     9421 ttatccggaa gctggcgcag aaagaagcct gcgtgatcat cggaaggtct gcagattata
     9481 ttctgaaaga tacagaagga atccagctgg tgagagcatt tatttatgca cctaatgatg
     9541 ttcgcgtcca caacattatg gaaagccata atctctcgga aaaggatgca aagcttctgc
     9601 tggatgagaa ggataaacgt tatcataaga gacatctggc actgacagga agtaaccgtg
     9661 gtgacagaca taacagggat attcttatta acagtgattt tctgggaatt cagggaacag
     9721 cagaatatct ggaagacctg atcgcaaaaa aatacggaaa aaaggaggcc tgacctatgg
     9781 aacaaaaaac atcagaattt gacaaagtac ttggtgcatg ggacatactt gtaattgcat
     9841 ttggcgccat gatcggctgg ggctgggtag tttcttccgg taactggatt gaatccggtg
     9901 gtgtgcttgg tgcagctatt gcatttgcaa tcggtggaat catgattttc tttgtaggtc
     9961 tgacttacgc agagcttaca gcagctatgc ctcagtgtgg tggtgagcac gtattcagct
    10021 acagggcaat gggttctaca ggttctttta tctgtacctg ggcgattatt cttggatatg
    10081 taagtgttgc ctgctttgag gcatgtgcat ttcccacaat catcacttat ctgtggccgg
    10141 ggttcttgaa aggatatctc tatacagctg caggctttga tgtttatgca tcctggctga
    10201 tcgtggcaat tgtgatcgct tttcttatta tgataatcaa cattaatgga gcaaaaactg
    10261 cagcagtttt gcagactgtt cttacctgta ttatcggcgg tgccggaatt attctgatcg
    10321 tggcttctgt ggttacagga agtgtggata accttcaggg acagatgttt gttggaaacg
    10381 gtaccggtga agcaatgaaa agtattatta aggttgcagt tatcactccg tttttcttta
    10441 ttggttttga tgttatccca caggcagcag aggagattaa tgttccgctg aaaaaaatcg
    10501 gtaaaatgat gatcctctct gttgtgctgg ctgttgtatt ttactcactg gtgattcttg
    10561 cagtaggtta tatcctgaat ccggcagaga ttattgagtc tcagcaggga acaggacttg
    10621 taacggcaga tgccatggcc aaggctttcg ggacaaaggt tatggccaag gttatcattg
    10681 taggtggaat gtgtggtatt attacatcat ggaactcctt cctccttggc ggttcccgtg
    10741 ccatgtactc tatggcagaa tcctacatga ttcctccgtt ttttgcaaag cttcatccga
    10801 agcacaaaac tccggttaat tctctgtatc tgatcggtgc cctgactatg ctggctcctt
    10861 ttgcaggaag aacaatgatg gtctggatct gtgatgcagg taacttcgga tgctgccttg
    10921 catactgtat ggtctctgtc tctttcctga tccttcgtaa aaaggaaccg gatatggcaa
    10981 gaccttacaa agtaggccac tacaaatttg taggttttat ggcagtagtc atgtcagggc
    11041 tgatgcttct ggtttactgt attccgggtt ccggtggaag tctggtattt caggaatggc
    11101 ttatggtagg tagctggagt ttacttggag ttgtatttta tgcgatctgt aaacgtaaat
    11161 ataaagaaga ttttggtaaa cttattgaac tgatctctga tgaggatgca gcaagtctta
    11221 tgccggaggc tgatgatgaa gagcttgatg tggtaatcga tgcggctatt gacagggtgc
    11281 tttcctctat ggcataacgc tataaatgac atgacaatta ttttgggtaa cagagttttg
    11341 aatttgtgca gggtagatgc cctgcacatt gcaatattga aaaaatacag gaaaagaggc
    11401 agaaattaat gaatccattt gaatttttta ttcctcagaa tattacagtc ggtgcaggga
    11461 ctctggcgaa gcttccggaa tgtgccaaaa agcttggagg atctcatgca atgctgatct
    11521 caggaccaac tctccggaaa atgggagttg tggataaggc ggcggattat ctgaaagacg
    11581 ccggaatggc agtggatatt tttacagatg tagaagccaa tccgtctgtc accacagtgg
    11641 aaaaagcgac agaagcgtat aaggattccg gcgcagattt tatcgttgcg ctgggcggtg
    11701 gttctcctat ggatgtggca aaagcagtgg gagttacggc taaatatggc ggcagtatta
    11761 cagaatatga gggggcacat aaggttcccg gaaaaattgt tccgctgatc gcaatcccga
    11821 ctactgcggg aaccggctca gaggttacgg cattttctgt tatcactgac cacagcagag
    11881 attataagct gacggtattc agttatgaac ttcttcctgc atatgcgatc ctggatcctg
    11941 aacttctcac atctgctccg gcatctgtgg cagcagcctg cggaatcgat gcatttattc
    12001 atgcggagga ggcttatgtt tccacagcag catctccttt ttctgacgca atggcagaga
    12061 aagcaatgga gctgatcggt ggaaatatcc gccgttttgt ggcaagacgt acagatctgg
    12121 aggcagcaga agcaatgctt acaggctctc tttttgcagg aatcgccttt tcctttgcaa
    12181 gacttggaaa tgtccatgcc atgagtcatc cggtaagtgc tttctttaat gtagcacatg
    12241 gagtggcaaa tgcagttctt ctccctgtga ttgcagaata taatgcgctg gcagatcatg
    12301 gcagatatct gaagatttat aattatatca gtccgatccc tgcatatgag gatgaattcg
    12361 aaccgctgat gctggtggat gccatcaggg aattaaacga agatatcgga atcccggaag
    12421 acctgaccac agccatccgc caggcaaaga agggagaaga gatttctgat gaggagattg
    12481 aaagcaagat tgatgccatg gcagatgatg ctatgaagag cggaaatatt gcagtaaatc
    12541 caagatcctc cagaaagcag gatattgtgg aattgtatca taaggcttta taaattcaga
    12601 taaagaggaa tgcagtattt tatgtaattg ctacaggtta acagaaggta ttgattaaaa
    12661 atatctgcta ttataaaaaa cgtgcagaaa cattgaagtc gacagataac ttcaggtttg
    12721 aagatttatc ccgattttaa aatgtatctg cacgttgttt tttggagaaa tttccattgt
    12781 ataacttgcc tgatagaaag aaagattata tagtattaat caaaatatag taaagtaatg
    12841 tgagtcaaaa tattgattgt tcaggaggat tttatggcaa agaagaaaat atatgcagta
    12901 cgcaagggac ataaaacagg actttttgtt acatgggcgg agtgccagaa ggcagtaagc
    12961 ggatattcag gagctgagtt tcggggattt acagagaaag aggaagcatt ggcttttctg
    13021 aacatggaga caacaggaaa tgtatctggt gataaagcaa aagaggcggc aggaatcgtg
    13081 gaagtacctg aaaatatggt cattgcttat gtagatggaa gtttcgagaa aagcattggc
    13141 agatatgctt ttggctgtgt gatccttaca ccggacggac aggaaatccg caaatccgga
    13201 agtggcagtg accctgcagg agttgccatt cggaatgtgg caggcgagat gcttggttcc
    13261 atgactgcag taaactgggc catagaaaac aaatatccag ctgtggaaat ccgctatgat
    13321 tacgaaggtg tagagaagtg ggtaacaggt atgtggagag ccaaaacacc tctgaccagc
    13381 aaatatgctg ctcatatgca ggaagcagga aagaaagtaa agatttcttt ttgtaaaata
    13441 gcagctcata cgggcaatca ttacaatgaa gaggcagatc agctggctaa gagtgcattg
    13501 cttaaaatgg atgaagaagt acgaatataa aaatcttatc actgaaaggc gatttccaaa
    13561 gggatgaaaa gtttatgtgg atgacaattt gagtgatcct cagggaaatc aatatatgga
    13621 agtggaaaaa taaaaagcag ctgtgttacc attgaaactg ttagctgaaa tttttatcaa
    13681 gtaacagttt caattgacag gtaacgcagc tgttttcgct tatgaaagtg tcatatcccc
    13741 gtctttcacc catccaagct tacggataaa catgttgatg agcggacaca ggattgcagg
    13801 caggataaag gaaatcagca aaagtccggc ccagtcccag cctgtgacag ctgtttttgt
    13861 tcctgcggca atatcattca tccatccggt gtagacacca atctgtccta cgaaaccaca
    13921 ggtacccata ccggaagaaa ccggagtacc gttcatctga agtttgaaca gacaggttgc
    13981 aagaggtccg gtgatggcag aagtaaggat cggtgcaatc cagatgcgtg gattttttac
    14041 gatatttccc atctggagca tggatgttcc gattccctga gaaacaagac caccccattt
    14101 attttcgcgg aaggacatta ctgcgaaacc taccatctgt gcgcagcagc ctgctacagc
    14161 agctcctccg gcaagtccgg taaggccaag cgcagcacag attgcggcag atgagatagg
    14221 aagtgtcagt gcaataccca caaatacaga aacaaggatt cccatcagga acggctgcag
    14281 gttggttgcc cacataataa tatttcccac tttcattgct gcacttccaa gtgccggagc
    14341 ccaccatgcg gacagggcaa cacctacacc gatcgtgaca agtggagtga ccagaatatc
    14401 aattttggtt tccttagata ctgcttttcc gatttcggaa gcgaagatgg caacaaataa
    14461 tacagccaat ggtccgcctg caccgcctaa tgcgttagat gcaaagccaa cagtgatcag
    14521 tgagaacaac accaacggcg gacaatgcag cgcatagccg atggcgacag ccatggcagg
    14581 accgctcatg gcagatgcca gagagcctac ggtatactgt gtgtcgttta cagttgccac
    14641 agcagtggtc agaaatgaaa tatgaaactg tgttccaagt gtgttgatga tcgtgccgat
    14701 cagcaaggag cagaaaagac cctgcgccat ggcaccaagg gcatcgattc cataacgttt
    14761 tatggagatt tcgatgtctt tgcgtctgag aaatgcttta aacttttcca tagattactt
    14821 tctcctgttt ttattatgta tagaagggtg tatatacacc tatatacgct tttctcatta
    14881 tagtcacatt cacggagtaa atcaagtagt tttgtaactg ttcacatacc actatcccgc
    14941 gaggtgtttt ggcatgaata tgccaaaatc acaagacata caagccaaaa ttccattgcc
    15001 gcaggcaatc tggaatgaat tttgggtacg ttactgtgaa cggagtgaac caatgtcatt
    15061 aacttaagca atttgccaat actgcattga tgaaaatatc agcagaagga tttgattatg
    15121 ataaaaagga aatattgagg gattaagatg taatgtcttg ctgaaattcg ggtataacaa
    15181 aaagacaaaa
//
