LOCUS       c00029_gnlPro..        16545 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GAGFMGDE_29.
ACCESSION   c00029_gnlPro..
VERSION     c00029_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:36:58
            Original ID  :: gnl|Prokka|GAGFMGDE_29
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16545
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16545
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3296:6545]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3297..6545
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..16545
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16545
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             3..176
                     /locus_tag="ctg29_1"
                     /transl_table=11
                     /translation="SINHFKDSFCIADRKTQIEKTLHADLLLAGITQLVTVLVADKIHQ
                     YQYIRSLKRLIA"
     CDS             complement(518..979)
                     /locus_tag="ctg29_2"
                     /transl_table=11
                     /translation="MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQ
                     EVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLS
                     TWHGKAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ"
     CDS             complement(1179..2057)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_3"
                     /sec_met_domain="CN_hydrolase (E-value: 6.2e-56, bitscore:
                     181.4, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELF
                     ERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVL
                     DADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETAR
                     CMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPC
                     PENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDR
                     RPEMYAKIVGK"
     CDS             complement(2159..3262)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_4"
                     /sec_met_domain="PAD_porph (E-value: 1.6e-127, bitscore:
                     417.0, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVTEKNRTKYRMPGEFEPHEGCVMIWPERPGSWNYGAREAQKAF
                     VKVAEAIGVSEKVYMLVSKAQMENAKNQLGNVSGVTLLECETDDAWARDVGATMVLDEK
                     GAVCGVDWQFNAWGGTFDGLYRNWEKDDRVAAFICRTLGCPCLDARPFVLEGGSIHSDG
                     EGTLIVTEACLLSQGRNPQMSREQIEEQLKYWLGVHKIIWLPCGIYQDETNEHVDNVCA
                     FVRPGEVVLAWTEDETDPQYAMSLADLKVLEQETDAKGRKFKIHKLPIPQKPVCLTQED
                     VDGFVFEEGEDEREAGERMAASYVNFYISNGGIILPQFGDENDKRAVEILQKCFPERRI
                     YPIDARAIIVGGGNIHCITQQIPGKNI"
     CDS             complement(3297..4418)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_5"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 6.4e-15,
                     bitscore: 47.2, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKINQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYNVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIQIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             complement(4408..5688)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_6"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 2.2e-43, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.1e-35,
                     bitscore: 114.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKK
                     KIESTTKTKIETAKVDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYNEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(5685..6545)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_7"
                     /sec_met_domain="Spermine_synth (E-value: 1.8e-53,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 2.6e-15,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(6548..8005)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_8"
                     /sec_met_domain="OKR_DC_1_C (E-value: 2.5e-13, bitscore:
                     42.4, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 3.1e-126,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQTAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEYLQVLKGGI"
     CDS             9132..10817
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_9"
                     /sec_met_domain="FTHFS (E-value: 2.5e-275, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(10926..12350)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_10"
                     /sec_met_domain="Lyase_1 (E-value: 1.3e-94, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 5e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             12466..13401
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg29_11"
                     /sec_met_domain="LysR_substrate (E-value: 1.8e-33,
                     bitscore: 107.5, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.1e-18, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFERYIYQKEQ
                     LLLAVPKNYSINTRLQKYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(13513..14970)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_12"
                     /sec_met_domain="FGGY_C (E-value: 2.2e-37, bitscore: 120.6,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 8.3e-80, bitscore: 259.7,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFIQSMEGMKELTKDIDRTQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARGLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
ORIGIN
        1 agtcaatcaa ccatttcaaa gatagtttct gcattgcaga tcgtaaaaca cagattgaga
       61 aaacacttca tgctgattta ctgcttgcag gaattaccca gcttgttact gtgcttgtcg
      121 ctgataagat tcatcaatac caatacatcc ggagtttgaa gcgtttgatt gcctgattat
      181 taatattcat acaatctttt ctgctcagtt tatctgggaa gtcttttagt aattttcaaa
      241 tttagaagta cctatttttc atcttaagaa tcctgcgttg caggattctt accgcttttt
      301 agtcaggatt gcgaacttgt ttcgcaatta cctacaaaaa atataaaaat gaatgtggga
      361 tttttccctg cacctggcag gattaaagaa tagaaataag ttgagattgt atgattataa
      421 atattcaagg ggaattaata tcgtgaaaca agaacgttta cacttaagat tttaagattc
      481 tgcgcagggt ttcttttctg aaaccctgca cagattttca ttgatcattt cttttcttca
      541 gccatgaaag aaaataaaga ataattgcaa gaataataaa aaacggaatc gcaactccga
      601 ttatcagtat cagtaaaaca attataacag ccgccgctgc aataacaaca gccttgccat
      661 gccaggtaga aagatcgatt acttttttcc atcttttctc ctgctgatga ggaagctctg
      721 tctcattgcc ataactactt ccgtaagaag aatactctcc gtaatcttcc tgtgtacttc
      781 catcatctgt atcgatcaga gtttttgcta tcagatgcgg gtctcccagt tcctgcagta
      841 cttcctgctc tgaacgtccg ccacgtacct gagactgtat ataatcttca taatacctga
      901 tatgtgctgc tgctttgccc tcctgcatct gcccggcaag ctggcttctc aggatttcca
      961 aaaattcttt tctgttcatc ttctacactc cattttgcca gaaatacata tcaaaactct
     1021 actgctctct ccgttatcag taacgttcgt actcttattt taccatatat accgcaggta
     1081 gcaactaata taatcataaa ctttttatga aattcttata aacacatata tcgttttgga
     1141 aataacactg caaatccact cggattctcc tgctttcgtc attttccgac aatttttgca
     1201 tacatctccg gtctgcggtc tctgaaaagt ccccagttca gtctgtctgc ctttaatgca
     1261 tccaggtcaa aagtgcttac aagcaccccc tcttcccctc cgggcagttc tgcacagaga
     1321 gcacctgtgt tgtctgtgat aaaagaagag ccgtaaaaat taagagcaga tttctgcatt
     1381 ccgttttccg gacatggctc tactgtttcc tcaccgattc tgttggcagc gatcacaggg
     1441 atcaggttgg aggcagcgtg tccctgcata catcttctcc agtgttccat gctgtcgcat
     1501 tccaggatgg gttcacttcc gatggcagtg ggataaaaga gaagctctgc tccctgcagt
     1561 gccatacatc ttgccgtttc cgggaaccac tgatcccagc agattccaac tccaatggtt
     1621 ccaaatctgg tatcaaaaac cttaaagccg gtatctcccg gtgtgaaata gaatttttcc
     1681 tgataataat ggtcatccgg aatatgtgtt ttccgataaa tgccgagatt ctttccatct
     1741 gcatccagaa ccgcaacgct gttataagta ttattgacct ctttttcata aaagctgacc
     1801 ggaatcacaa tccccaactc tgccgctacc ctgctgaaat gacgcactgc agggttttcc
     1861 tctgcagtct gcgcatattc ataatactca tatctgcgct cctggcagaa atagggccgt
     1921 tcaaaaagct ccggcagaag aacaatctca gctccctttg ctgctgcctg acgcaccagt
     1981 tcctctgcat gggcaatatt tttctccaca cttttactgc atttcatctg aactgctgcc
     2041 actgttacat ttctcatcct gtctgttcct cctgctcctg tttacataag taagtttttt
     2101 cataactttc aggtaataac cctcaaacac atgactctca aagttttctg catcaaggtc
     2161 agatattttt tccgggaatc tgctgggtga tacagtgaat atttccaccg ccaacaatga
     2221 tggctctggc atcaatggga taaatccttc tttcaggaaa acacttctgc agaatctcca
     2281 ctgccctttt gtcattttca tccccaaatt gtggaaggat gatccctcca ttggaaatat
     2341 agaaattcac gtaactggca gccatccgtt ctcctgcttc ccgttcgtct tctccctctt
     2401 caaacacaaa gccatccaca tcttcctggg taaggcagac cggtttctga ggaatcggaa
     2461 gcttatgaat cttaaatttt ctgccctttg catctgtttc ctgttccagc accttcagat
     2521 cagccaaaga catggcatac tgcggatctg tctcatcctc tgtccatgca agcacaacct
     2581 ctccgggcct tacaaaagcg cacacgttat ccacatgctc attggtttca tcctgataga
     2641 ttccacatgg aagccagata atcttgtgga caccgagcca gtacttcaac tgttcctcta
     2701 tctgttccct gctcatctga ggattgcgtc cctgactcag aagacaggcc tctgtaacaa
     2761 tcagagtccc ctctccgtca gaatggatgg aaccgccctc cagcacaaaa ggtctggcat
     2821 ccagacatgg acaaccgaga gtcctgcaga taaaggcagc caccctgtca tccttttccc
     2881 agttccggta aagcccgtca aaggtacctc cccaggcatt aaactgccag tcaactccac
     2941 agaccgcccc tttctcatcc agaaccatgg ttgctcccac atctctggcc caggcgtcat
     3001 ctgtctcgca ttccagcaaa gtcacaccgg aaacattccc aagctgattc tttgcattct
     3061 ccatctgagc tttggaaacc agcatataca ccttttcgct cactccaata gcctctgcaa
     3121 ctttcacaaa tgctttctgt gcttcccttg ccccataatt ccaggaaccg ggacgttccg
     3181 gccagatcat cacacatccc tcatgaggct caaattctcc gggcatacga tattttgttc
     3241 tgttcttctc tgtaacttcc atgtctgtct ccttttcttt gatagcccgg cagatatcag
     3301 gaaagccggc tcttaaagtc ttcgtatccg aaatgtctga taacctcaca ctctccgtcc
     3361 tcatgcataa ccgcaatatc cggcagcggc ataccgttaa atgtattatt cttcaccata
     3421 gaataaatcg ccatatccat aaaatacagc ttgtccccga tctggatctc tctgtcaaag
     3481 gaataatctc cgatcacatc tcctgccagg caggtgcagg aagataagcg gtaggtatat
     3541 gccttctccc ctgcttcccc gctgtcctta agaggcggac gatagggcat ctccagcaca
     3601 tccggcatat ggcaggctgc agaagcatcc aaaatcagcg ttctgatctc attttccaca
     3661 atgtccataa cctctgtcac cagatatccg gcattcaggg caacagcctc cccgggctcc
     3721 agataaatat ccagatcata ggtttccttc atatgctgaa tacatttttc caggagcttt
     3781 acattataat cctctctggt aatatgatgt ccgccaccca tattcagcca ggaaacctca
     3841 gacagaaatt ctccaaactt ctcctctacc gcctgcaatg ttttctccag gtcatccgca
     3901 ttctgttcgc agagcgtatg aaaatgcagt ccgtcgatcc atttcagaca ttccccgtca
     3961 aagttctctc tggtaacccc cagccttgaa cccggcgcac agggatcata gatcgcatga
     4021 tccccctgag tggagcattc cggattaata cggagtccca gactggctcc ggtacacact
     4081 tctttaaatt tcttcagctg tgctgtggaa ttaaagataa tatggtcaca gatccgatcc
     4141 agttcctcta tatcttctgt acggtaagca ggggaaaaaa catgattctc tttccccatc
     4201 tcttcatatc caagccttgc ctcaaacaga ccgctggcag tggtacctgc cagatatttt
     4261 ccgatcatgg gatacagagc aaaaccggaa aacgctttct gcgccagaag gatcttacac
     4321 ccggtatcct cctggacttt tttcaaaatc tccagattct cccgcatctt cttctcatcg
     4381 atcacatagc agggagtttg cagttgatta atcttcattg gctttccaga cctttaccag
     4441 ttcaggatct tcgcagactt tccatggaag tccccatttg ttcagtgctt ccatatatgg
     4501 atccggatca aattcttcca cattaaatac acccggcttc ttccactgtc cggtcactac
     4561 catcatggaa ccgatcatag ccggaacacc tgttgtatag gagattgcct gggattccac
     4621 ctctttatag cattcctgat gatcacatac attataaata taaatacttt tctcttttcc
     4681 gtccttaaca cctgtgaaaa tacagccgat atttgtttta cccactgttc tcggacccaa
     4741 agatgcagga tccggcagaa gagctttcaa aaactggatc ggcacgatct cctgtccatt
     4801 aaattccaca ggtgcggtgg aaagcattcc tacattttcc agacatttca tatgtgtcag
     4861 atagctctgt ccgaatgtca taaagaaacg gatcctctgt actcccggaa tattttttgc
     4921 cagtgattca atctcttcat gatgaagaag atacatatcc ttctttccta cctcagggaa
     4981 atcatagaca gatttaaatt ccataggctc tgtttctacc caatgtccgt cttcccagta
     5041 ggaaccattt gcggaaacct ctcgaagatt gatctccggg ttaaagtttg tggcaaaagg
     5101 atatccatga tcaccgccgt tacagtccag aatatcaatg gtatggattt catcaaaata
     5161 atgcttcaag gcataggcac tgaatacact ggtaacaccc ggatcaaaac cggttcccag
     5221 aagagcagtc agtcctgctt ccttaaattt ctcattataa gcccactgcc aggaataatc
     5281 gaaatatgca gtaaagcctt tttctttaca tctcttttcg tagattgcac gccatgtggg
     5341 atcttctgta tcctctgctt cataattggc agtatcaata taatccgcac cggcttccag
     5401 acatgcatcc atgatggtaa gatcctgata tggaagtgcc acattcagga cagcatccgg
     5461 cttataggct ctgatcaatt ctgcgacctc tgctgcatta tccgcatcta cctttgctgt
     5521 ctcaattttt gtcttcgttg tactttcaat cttctttttg agtgcatcgc atttttcctt
     5581 tgtcctgctt gcgatcataa tctctgtaaa aacatcgctg ttctgacagc atttgcgaat
     5641 tgccactgaa gctaccccac cacatccgat taccaataat ctactcataa actgttttcc
     5701 tcctcttcca gtaaatcttc tacatatttt ggaagcataa atgctcctct gtgaaggttt
     5761 gttgtataat accatgtttc tatattaaga ttatcaaacc tctccggcct gaaatcttcc
     5821 agtggatgat atttctttga tgcaaatcca aaaagccagt atcccgaggg acaggtaggg
     5881 atatgtgcct gataaaccct gctcaccgga aatgaccgga aaacctttct gtgcatcttt
     5941 ctgcattcca cctcatcctc atcataaaaa ggacttccat gctgataaac catgattccg
     6001 tcatctctga gagccttata acagcttccg tagaattcct ttgtaaaaag tccctctgta
     6061 tgtcccagcg gatctgtgga atcattgatg atcaggtcat atctggcctt tttattccgc
     6121 aggaaccgaa ggccgtcttc ataataaatg ttgactctct catccttcag tccctgggca
     6181 atatccggaa acatctccgc acatacatcc acaaacattt tatcggattc caccacatca
     6241 atgctctcaa tctgtggata atggatcagt tctctggcaa ctccaccgtc accgccaccg
     6301 ataatcagaa cattttttac attgggatgt actgtcattg gcacatgcgt gaccatttca
     6361 tcataaataa attcatcctt gtcagaaaat acgatctcac cgtccagagc cacaaatctt
     6421 ccaaattctt cagactcaaa cacatcgatt ctctgaaatt cactttcccc tgaaaataac
     6481 tgtcggttaa tccggacaga aagctttaca tttcctgtat ggaactcgga ataccataat
     6541 tccatgatca gataccccct ttcagaacct gaagatattc taccttcgga tcctccattc
     6601 cctgcatgga acagcctttg tctcttgcat aaagaatgta ttctacaatt tcctgtgtca
     6661 ccatttcccc aggagcaaga atcgggattc ccggaggata acacataaca aattcaccgc
     6721 tgatcctgcc tgccgtctgt tccatgggca gagattcttt ctccgcataa aatgcctgct
     6781 gtggagacgc caccactgca ggtgcgatat attccccgga aagcatacct gtgctgtcct
     6841 tcttatacag acgttcaata tcagccaatg cccctaccag tctctcaata tcctgaagcc
     6901 tgtctccaat ggaaatgtaa gccagaatat tacagatatc tccaaactcg atctgaatat
     6961 catattcatc tctgagaaga tcataaactt caatacctgc cagcccattt cccagtgtat
     7021 aaatggagag ttttgtaaca tcaaaatcaa aaacactggt tccattgatc agatccatac
     7081 catatgcata ataaccgccg atctcattga tctcctctct ggcatactgc gccatccctg
     7141 caaccttttc aaaggattcc tctcccctga gtgccagatt tcttctggag atatccagac
     7201 tggacaacag aagataagaa gcgcttgtgg tctgagtcag attgatgatc tggcgcactt
     7261 tctctgcatt catactctta ttcaaaagca gcagcgaact ctgtgtcaga cttccgccgg
     7321 atttgtgcat ggaaactgcc gccatgtcag cacctgccgc cattccggat acaggaaggt
     7381 ttctgccgaa ataaagatgg gttccatgag cctcatctgc cagcaccttc attcctcttg
     7441 catgagcctt ctttacgata gtccgcagat ccgaacagat tccataatag gtagggttat
     7501 ttacaagaac tgccaccgca tccggattct catccatagc cttctccacc tgactgactt
     7561 ccatgccaag ggaaatgccc agctgcgcat tcacctccgg gtttacataa accggaattg
     7621 caccgcacag taccagggca ttgatggcac ttttatgtac atttcgcggc agaatgatct
     7681 tatcccctgc cttgcagaca gacaggatca tgctctgcac tgcagatgtg gttcctccta
     7741 ccataaggaa tgcatgcgct gcgccaaaag catctgctgc aagctcctcc gcttctctga
     7801 tcaccgaaac cgggtggcag agattgtcca gcggcttcat agaattaaca tccagcccca
     7861 cacatttctc tcccagcaac tgtgcaagct ccggatttcc tcttcctctt ttatgtcccg
     7921 gcacatcaaa gggaacgact ctcttctttc ggaaacgttc cagtgcttca tatatgggcg
     7981 catgctgttg tctttcataa tccatttgac atgttcctct tttcctgtcg tcatgtaccg
     8041 gcaaatacag ttctatcatt cagcaattgt atactgcctc aaaccggcac aatgattcaa
     8101 ttatttctct atatattcaa gtcgaacgca tgtgagacac atcctcgcaa agcgtttatc
     8161 tccaaccata tcctttatat ttgctatatc tgcacaaaaa aagaagcaga taagttcatt
     8221 caccatctgc ttctctcatg atctatagaa tttctcaggc tctgtctctt tatatactga
     8281 ccggatttcc cgtataaatc cgtctgtatc ctgtgcctgt tcccgtattc tgaaatattc
     8341 atgactgctg tcgtcttcaa tcgctggcaa atatatgcta tgctcttatt gaccgtttca
     8401 caagatgatg tgtgcttacg cactgattat tataaagtaa tcaacttata aaatttgagc
     8461 ttctaactca atcaataatg tggtgtctcc cacccggcaa ctgccccgcc tgtccgtatg
     8521 gcttaacatt cagaaactgt ctctgaatgt gagcaaatat ttgcatgaaa acgatagtgt
     8581 cttttcatac taaagatgag aataacatat cttctgaact gttgtcaatt ccattttcca
     8641 tattttgcac agtctttacc cgctttttat attttcttca tttatcaggg aaaactatgt
     8701 ctatttttta acaatttctt tccttgagaa aacgtatttt ctttcattac cagggattac
     8761 gattctcttc tcttatcaat ttgcacaact tttatccagt ttactcacat tttttgacgt
     8821 ttcaacaaaa attttcttga catttttttc tcaaaatgat atattgtatt catcaattga
     8881 aagaaccttc gagtactgac ggaaagagtg gagtgcaaac cacgtggagt cggaggtttg
     8941 tgggagccga ccgtctgggc agtatttgaa atattcagat actggccttt ttttataact
     9001 ttcagggcag aaatcaggaa taccaggcag accggccaat acttctttca attaataatt
     9061 gttgctgatc gcggagtgaa cagcaacaga agtttttcat gttatgcgga aacgaaagga
     9121 gaaaaacaat tatgggattc aaatcagaca ttgaaattgc acaggaatgc gagatgcttc
     9181 caattactca gatcgcagag aaagcaggta ttgacgacaa atatctggag cagtacggaa
     9241 aatacaaagc aaaaatcgac tacaatcttc tgaaagaaag tgataagaag gatggaaaat
     9301 taatcctcgt tacagctatc aacccaactc cagcaggaga aggtaaaact actactactg
     9361 taggtcttgc agatggtatg cagagacttg gcaagagtgt tatggtagct cttcgtgagc
     9421 catccttagg accggtattc ggtgtaaaag gtggtgcagc aggcggcgga tatgcacagg
     9481 ttgttcctat ggaagatatt aaccttcact tcacaggtga cttccatgcc attggcgcag
     9541 ctaacaactt actggcagct atgatcgata accatatctt ccagggcaat gcattaaaca
     9601 tcgacccacg taagatcaca tggagaagat gtgtagatat gaacgaccgt cagcttcgta
     9661 acgtagtaga tggtcttggc ggaaagacaa acggtatgcc tcgtgaagac ggatacgaca
     9721 tcacagttgc atctgaaatc atggcagttc tctgtcttgc aagcgacatc aaagacctga
     9781 aagaaagatt atccaagatc atcatcggat atacatacgg aaaagtttcc gagcagaaac
     9841 ctgtaacagc aggtgacctt cacgcagaag gcgctatgac agccctgtta aaagatgctc
     9901 tgaaaccaaa ccttgtacag actctggaac acgttcctgc aatcgtacat ggcggaccat
     9961 tcgcaaacat cgctcatgga tgtaactctg taacagctac aaagatggct atgaagcttg
    10021 ctgattatgc aatcacagaa gctggtttcg gtgctgacct tggtgctgag aaattccttg
    10081 atatcaaatg ccgtatggct ggtttaaaac caagcgcagt tgtaatcgta gctacagtac
    10141 gtgccctgaa atacaacggc ggcgttgcta aagctgacct taacaatgaa aacctggaag
    10201 ctcttgaaaa aggtatcccg aacctgttaa aacacgtttc caacatcaaa aacgtataca
    10261 aacttccatg tgttgttgct atcaacgcat tccctacaga tacaaaagca gagcttgact
    10321 ttgtagaagc taaatgtaaa gaactgggcg ttaacgttgc tctttctgaa gtatgggcaa
    10381 aaggcggcga aggcggaatc aaacttgcag aagaagttat ccgtcttgtt gaagaaccaa
    10441 acgacttctc ctatgcatat gaactggaag gttctatcga agacaaactg aaccagatcg
    10501 ttcagaaagt atatggcggt aagaaagtag ttctgacagc taacgctcag aaacaggcga
    10561 aacagttaga agctcttggc tttggcaact gcccgatctg tgtagctaag acacagtaca
    10621 gcttaacaga tgaccagact aaactgggtg ctcctactga cttcgaagtt acagtacgta
    10681 acctgaagat ttccgctggt gcaggattca tcgtagctct tacaggcgag atcatgacaa
    10741 tgccaggtct tcctaaagtt ccggctgctg agagaatcga cgtagacgag acaggtaaga
    10801 tcacaggtct gttctaatcc ggttgaaatc aatcgaataa ttcaaaaata taaaaatcat
    10861 atttatatat gatatgtgtc cagacgattt tacaggcggg aagattttcc cgcctgtttt
    10921 tttctttatt tttttataag ataatctttt ccggaaatac caggttccgt catatggatc
    10981 ggatccagaa tgcgattaag ttcatcctcg tccataagct tttctttcag aatcagactt
    11041 cttacagatt cgcctgtctt aattgccttt tttgcaatat ccgcagcctt ctgatatcca
    11101 agatgggggc tgattgcagt gataatacct acactgtttt ctaccagata acggcatctt
    11161 tcttcatttg ccgtaattcc tacaatacaa ttatctacca atgtctggac tgcatagcca
    11221 agagtatcga tagactgaaa catgcaatag aaaataatcg gctcaaacgc atttaattcc
    11281 agctgaccag cctctgcagc catggtaatg gtaacatcat taccaataat attaaaagca
    11341 acctgattca ctacttcagg aataaccgga ttaactttac ctggcataat agaggaacca
    11401 ttctgttttg ccggaagatt aatctcccca aaaccagtac gtggaccgga ggacatcaga
    11461 cggagatcat ttgacatttt ggaaagagtt accgcacatg ctttcacagc accggaaaca
    11521 gctacaaatg gatccagatt ctgagtggaa tcaatcagat caaaagcctg tataaagtcc
    11581 attcccgata tttcagtgag atttggaaca attcttctca gatagccctc atctgcatta
    11641 attcctgttc caatagcagt acctcccata ttaagagtcc gcatttcatc cattgcttta
    11701 tccattctgt ggatatcacg catgattgct accgaatatg ccttaaattc ctgtcccaga
    11761 cgaattggta ctgcatcctg catctgtgta cgccccattt ttattatgtg atcaaactct
    11821 gtagcttttt cattaagagc atcatagagg cgaagaagct gttttttcag attctgcaac
    11881 aaacgaagag aagtcatttt accggcagta ggaatcacgt cattggtaga ctgtccacaa
    11941 ttcacatcat cgttaggatt tataattgta taatcgccct tttttcctcc cagtatctca
    12001 atcgcgcgat ttgcaattac ttcattggca ttcatattta aagatgtgcc agctcctccc
    12061 tgaacaggat ccacaataaa ttcattatgg aattttcctg aaacaatttc atcacatgcc
    12121 tggacaatcg cctgtgcttt tttcttctca agaagcccca cctcacaatt ggttatcgct
    12181 gctgcttttt ttatgtatgc aagactgtta ataatttccg gatgcatatt cagccccgta
    12241 atgtggaaat tttcagccgc acgtaaggat tgtactccat aatatacatc ttccggaata
    12301 tcctttacac caatagaatc cctttctaca cgatagtctg tttttttcat agttattcgc
    12361 cctcccatgt atttgccctc attatatatc tctgctataa tataatcaaa tacatatatt
    12421 tttataaaat atatagtgtt taagttatat atcggaggag tttatatgtt tcagggaatg
    12481 gaatacatct atgaggtcta caaggaaaaa agcttttcca aagctgctgc tgctcttttc
    12541 atttcgcagc cttctttaag cgccaatgta aaacgtgtgg aaaaccgtat tggctatcct
    12601 atttttgatc gaagtaccaa acctttgcag ttaactgaag ttggaaaaca ttatatacag
    12661 gctgttgaaa aagtcatgga tattgaaaat aatctcgaaa actacctact ggatctggga
    12721 aatctcaaaa caggaactct taatgtaggt ggcagtaact ttttttcttc gtggattctg
    12781 cctcccctta ttgctgattt ttcccaaaaa ttcccccatg ttcaaatttc tcttgtagaa
    12841 gaaagtacag caaagctatc ccagtttctc caggccggaa agttagatct ggtgattgat
    12901 aactgtattc tggataacca gatttttgaa cgttatatct accagaaaga acaacttctt
    12961 cttgcagttc ccaaaaatta ttcaatcaat accagactgc agaaatatca gattcctatt
    13021 gaggaaatcc ggaacgggca gttccgttct tctcatattc cttctgttcc attaaacaaa
    13081 ttcgagaacg aaccatttat tattcttcgt tcagataatg ataccggtaa gcgtgcactt
    13141 accatttgtc aggaaaatca cttttcgcct tctgtagtat ttcgcctgga tcagcagatg
    13201 actgcctata atattgcatg tttgggaatg ggtatcactt tcatcgggga tcttctgctc
    13261 tccagagttc caacaaattc agaacttgtt ttttataagc tgcccggtca gagcagtaaa
    13321 cgcactgtgt ttttttactg gaagaaaggc cgctatatca gcagagccat ggaagaattc
    13381 ctgaagctgc ccttttcctg atatgtcata atcaaatagg ctatggtgat tggtcatcat
    13441 cagatgtacg tcaaaatggg gttgttgtgc taaataagca caacaacccc agtatgtcag
    13501 gcagatattc gattagaaca atggcttcat cgccggatac agagttctga acttctgata
    13561 tctctcttca tattttgcaa ccagttcagg atccggttct actgtatcaa caactttggc
    13621 aaatttctta ccgatggttt ctacatccgg gtaagcacca cagcctactg ctgccagcat
    13681 agctccaccc atggacggtc cttcttcgtt ctccagaaca tcaaccttca ggttcataac
    13741 gtttgcaata atcttcttcc acagtgggct cttagctccg ccaccgcaga tcttggttct
    13801 ctcaatcttg attccaaggc ctcttgcaac ttccagggaa tcacgaagac caaaggcaac
    13861 accttccaga acagcctgtg tcatgtctgc tcttgtgctg tccatggaca tcccgaagaa
    13921 tacacctctt gcatcaggat tattatgagg tgaacgttct cccatcaaat atggaaggaa
    13981 gaatacatga ttctctccca gcttctgaat tggagcctgc tctgctgcga aatcctttgt
    14041 ctgaagaatc tcctctgccc accatttgtt acaggaagct gcgctgagca tgcatcccat
    14101 cagatgatag cttccatctg catgacaaaa agaatgaagt gcgttatttt cgtccacacc
    14161 aaagttttta ctggaaataa acacagttcc ggatgttcca agagaaatat tacactgacc
    14221 gtcaccaact gtacctgttc ctacagcagc tgccgcattg tcacctgcac ctgcaacaac
    14281 ttttacattc tcactgaatc caagttcttt cgcaatctca ggtttcagag ttcctactac
    14341 ttcccaactc tcatacagtt tcggaagctg ctcttctgtg attccacaga tctccagcat
    14401 ttcttttgac cagcagcggt tcttcacatc aagaagaagc ataccggaag catcagaaac
    14461 atctgtacaa aaagaaccag acagacgata tgccagataa tccttaggaa gcataatctt
    14521 tactaccttc ttaaagttct caggctcatt tttctgcatc cagaggatct tcggtgctgt
    14581 gaagcctgcg aaagcaatat ttgctgtata ctgtgaaagt ttgtcttttc cgatcactgt
    14641 attcagatat tctgtctctt cgcctgtacg tccgtcattc cagaggattg caggacggat
    14701 tacattatca tctttgtcaa gagttacaag gccatgcatc tggccaccaa aaccaattcc
    14761 tgctacttga gttctgtcaa tatcctttgt cagttctttc atgccttcca tgctctgtat
    14821 gaaccagtcc tccggtttct gctcagacca gcccggatgt gggaagaata atggatattc
    14881 tctggatacg atgttacaga tttttcctga ttcttccata agaagaagtt ttacagcgga
    14941 agtaccaaga tcaataccga tataatacat aagtgcgctc cttttctatt tctaatctaa
    15001 tacatcccag agcaaagccc cgggatgcct ttaatatagt gtcagtttat ttattctgta
    15061 ttcagattca ttcacatcac atgaacatta ataacccgtt ttactgattt ctcattaacc
    15121 ccatggattc tctgtcggat atcttacacc tgccggctgg ttgtatccaa tcttcttaac
    15181 atccagtcca aggaatttca ctacctcata gaatgctttt ccgtaatgtc caaacataac
    15241 tgctccatga tgcggatagt tgccctcgat cagtacgtga cggtagaatc ttcccatttc
    15301 tttgattgcg aaaataccga taccaccgaa tgatcttgta ggtacatcca gtacttcacc
    15361 ttctgcaaca taagaaacca gctcgccctc ggaattgcac tgtaaacgat agaatgtaat
    15421 atcagatgca gcaatatcac cttcaagagt tcctcttgta aagtctggtt cagatcctgc
    15481 cggctcaaga agtctgtgct ggatcagctg atatttaaca gctctggaat cacacatctt
    15541 gcatgcagga gtatttccac aatggaatcc cataaatgta tcagtaagct tgtaatcgta
    15601 ttttcctttg atatcttcat catagatata ctgtggaaca gagttgttga tatcaagcag
    15661 tgtaactgca tcattggaaa tgcaaagtcc gatgtactca ctaagtgctc cgtagatatc
    15721 aacctcacag gataccggga ttcctctgga aaccagacgg ctgtttacat agcaaggttc
    15781 aaatccaaac tgtgacggga atgctggcca gcatttgtca gcaaatgcaa catattttct
    15841 tgctccctta tgagcctctg cccagtcaag aagtgtaagc tcaaactgtg ccattttcac
    15901 attaaggtca gcataatatt tgccttcgcc catctctttt gccatatctg cacaaacttc
    15961 cgggatacga ggatcatttt catgctcttt gaaagaaaca agaagatcaa gctctgagtt
    16021 ctcttcaatc tcaacaccca gctcataaag gcctttaata ggtgcgttgc atgcgaagaa
    16081 gtcctgtgga cgtggtccga aagtaatgat cttaagattg ctgacaccga tgactgcacg
    16141 tgcaaccggt acgaaatcag cgatcatctt tgcaatatca tctgctgttc caacaggata
    16201 ttccggaata tatgctttca gatgacgcat ttttaagttg taggagcagt taagcatacc
    16261 acagtaagca tcacctctgc cgttgatcat atcaccgtca ccttctgctg ctgctacata
    16321 catacaaggt ccgtcaaatc tctctgcgat cagagtttca ggagtttcag gtccgaagtt
    16381 tccaaggaaa acaaccagcg cattacactc tgctttgttt acatcttcaa gagctttctc
    16441 catatccttc tcgttctcaa cagttacagg acattcataa agttcacctt tataagtttc
    16501 cttgattgct gcacgtctct tttcagaaag ctgaatcgga aaaca
//
