LOCUS       c00028_gnlPro..        14543 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GABJAGOC_28.
ACCESSION   c00028_gnlPro..
VERSION     c00028_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:58:56
            Original ID  :: gnl|Prokka|GABJAGOC_28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6017
            Orig. end    :: 20560
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14543
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[16017:19245]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14543
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14543
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             459..842
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MEKIKEMIDVNTIIGEPITSPDGTLIIPVSKVSYGFAAGGSDLPT
                     KKENKDCFGGGSGAGVTIQPVAFLTVYQGDVRLVSVDREEGTADKLVNMIPDVLKKVKG
                     VFKKDKSESADDFSEITQDDIDG"
     CDS             894..2018
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_9"
                     /sec_met_domain="Peptidase_S11 (E-value: 5.1e-59, bitscore:
                     189.9, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIISLAVCFVMPFVLMGAKTAEDTPPTTSAQAFVLYCPDNNTV
                     ICSKNADERMKPASTTKIMTSLITLEEAASCNSEVTFKQEMVAEGSSMYLKVGEKVRLS
                     DLASGMMMASGNDAANAAAYTISGSPEKFSQRMNEKAKQIGMTNTNFVTPSGLDDDNHY
                     SSAKDMALLMSYALENDDFANLTAKKSVTVEFLEPKSKKTAYANHNRLLSLYPYCTGGK
                     TGYTTAAGRCLVSSAKKDGVTLVCVTLNDRNDWNDHISLYDYAFEKYRGVDCKDADFCA
                     DIPCVGGDKNSVTVTGEKNNTIVLKREDCDKIKKKIFIDSFLYAPIEKNESVGRIEYTL
                     GGKLLYKCNIVAGDKIKSDKKSVSIFSAIGNLFS"
     CDS             2062..2811
                     /locus_tag="ctg28_10"
                     /transl_table=11
                     /translation="MAKIEPIRLQKFIAQCGIASRRKAEELILGGHVKVNGKTAILGDK
                     VLPTDKVFVRGKRIVVPKGGNYRYIMLNKPRGFITTMNDERGRKCVAQLVENVGERVYP
                     IGRLDKDSEGMLVFTNDGDFANKVMHPKNNVYKIYRVTVRPSIDEDQLVKLETGVELDG
                     RKTAPAYVHVIHKEQGRVVLEMILHEGKNREIRRMCEAVGLEVARLKRTQIGGVKMGML
                     KQGDWRDLTEQEVKKLLANPFLNGKQL"
     CDS             3021..4355
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CT_Btheta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_11"
                     /sec_met_domain="CT_Btheta (E-value: 1.4e-67, bitscore:
                     218.6, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVLEDFKMSIEKINQAKAEIAATSAYKTITAFFDADSFCEIDAFA
                     KSGEGFAEVVAGFGTVEGMPVYAFAQNSDICGGAMSKAQAAKLKKLYGLALKTGAPVVG
                     FYDSVGGRLNQGTELLAGCGDVLNAAASLSGVVPQISVVLGTCLGTNALNAASADIVIM
                     SKDAQLSLSVTGKHSDAAYNAENGIASIVCDDADKAIKAAKELILYLPSNNLTMAPQSF
                     EEAPAEDGCGCVVSRTVDGNSIVKLFNDYGKEANVRFARLGGQVVGIVVTKGKELGCKS
                     ANKVAKFVRFCDAFSLPVVTFVNCPGFESIKSATKASAAYAEATTVKISVVTGKAIGSG
                     YVALAGTGANADVVYALPDAVISPVNVEAAAFIMAPEVMNVATDKQAEVAQKFADENLS
                     AYNAAQNGYVDGIVEEAQLRQTLISALDMLSGKRVSTLSKKHSTI"
     CDS             4394..4759
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.7; E-value:
                     8.2e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_12"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.5e-21, bitscore:
                     65.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLRITVNGTAYDVQVEELGGSSAPAAAAPAPAAAPAPAAKPAA
                     PAGAQGSVVVKAPMPGTVVNVVVSAGQAVKAGDDLVFIEAMKMETPVKAPQDGTVATVD
                     VAKGESVDSGKVLVTLN"
     CDS             4790..6193
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_13"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-49, bitscore:
                     159.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1e-55, bitscore: 178.9,
                     seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKIRVTETALRDAHQSLIATRMTTEEMLPVLDKLDKIGYYSLE
                     CWGGATYDSCLRFLNEDPWDRLRTIREHCPNTKLQMLFRGQNMLGYRHYADDCVEYLVQ
                     RSIANGIDIIRIFDALNDIKNLKTAIKAANKEGGHAQVAISYTTGPVFTDEYYVEYAKR
                     IADAGADSICIKDMAALLTPTRTESLVKAIKAAVPELPLQLHTHYTSGLASMCLLKGVE
                     AGADGIDTAISPLALGTSHAPTESMVAALSGTEFDTGLDLKQFSDIRAYFMTLREKYIK
                     SGLLDPKMLATDANALIYQVPGGMLSNLLSQLKQAGKEDKLDEVLAEVPRVRKDSGYPP
                     LVTPTSQIVGTQAVFNVITGKRYSMCTNEFKGLVAGEYGTTPMPIDPEFQKKIIGDKKI
                     IKGRPADQLEPELDKLRGEIEQWIEQPEDVLSYAQFPKVALDFFEKRRNAKVGINGDKL
                     DKKNMVHPV"
     CDS             6387..7409
                     /locus_tag="ctg28_14"
                     /transl_table=11
                     /translation="MKKFLTVLIAFVMCFSVVTTAFAATPDEVSDSDLISDIKQAMLDT
                     YYGDEKPDFIEVRIYGTASDGGVYFDFMDSFTHWTDEVEFDIGDYTVSYPRDCPVLLYK
                     NNKVYTLSDAYETGVIDDDMLYELYVWGNLWGKIDVTPKGEDRALLSEIKRVIINKYYN
                     GKAPEYLNVEIVGSTSDETVCFRNIPFMSLGVMIEQTIGDYTYYYNHGDDVMLYKNGNV
                     YSIKEAYESGVIDDSILEELSKMNFGLESNKPNTTVPTEPTTSVATVDEPVTVPDTTSA
                     TSATKPVSTSDTATNDTPNNSQNNSGAVQTGQNSVAVILLVAMLAGCAVIFAKRRNYFK
                     "
     CDS             7861..9708
                     /locus_tag="ctg28_15"
                     /transl_table=11
                     /translation="MVDTTSTSYIDKDVSSGRNYTYTVRCISADGKSFTSGYDSKGTTV
                     KYIAAPEISKLENVNGGVKISWGKVSGAAKYRVYYKGSKGWTRMVDTTSTSYIDKDVSS
                     GRNYTYTVRCISADGKSFTSGYDSKGTIIKYIAAPEISKLENVNGGVKISWGKVSGATK
                     YRVYYKGSKGWTRMVDTTSTSYIDKDVSSGRNYTYTVRCITSDAKKFTSGYNPTGKSVK
                     YVATPKISKTEVTYDGVKLTWNKVAGAEKYRVYYKDRNGWTKLADTTGTTMLDMNVVSK
                     EFDLSVDDIYYTVRCISKDAKSFTSGYDSKGTPIGDHQDCPEIYSIGAVNNGVEMHWTG
                     DAPKFRVYIKENGSWKKIAETYDNYYVHKGARSGSNTYTVRGVSKDGKKFTTMFNPTGV
                     TYRYKTSDKTRDAYINYMMNHQSEWMPSLGSNHNLSGVMFLDFDFDGVPELVAQKADSN
                     EYSFHSVVYKFEDGKLKRVGNVNDGFAIYYNKTAKKYEVHDLKISLNVDDGYYWSGNSI
                     ITYDGENLFANMYSARGVGEESNNNIYYNYFDGNDKNISRAKYNEINLKQFNNCVNAHM
                     FTKFIVTGYGDNSVWSENTTAENKQSLLDAYNSFSYEKY"
     CDS             complement(10001..11041)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_16"
                     /sec_met_domain="IlvN (E-value: 1.2e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.1e-61, bitscore: 194.7,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYEGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKLAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
     CDS             complement(11102..11593)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_17"
                     /sec_met_domain="ALS_ss_C (E-value: 2.6e-30, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQDPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             complement(11606..13228)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_18"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.1e-43, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             complement(13426..14541)
                     /locus_tag="ctg28_19"
                     /transl_table=11
                     /translation="LSLDSDTDSETEFNYDLEIYYNDKKIDNLNLFDALMPTEDGLIYS
                     KINETSPNEIEYYRYYLDKKSSIKLGSIKDWTMQINDKAYVNNHLCFMASTGDITDEEN
                     RTLEFIDIDLNKNKMTTVFSDKGGFPYDTVTGADNLVIITKVLNNGTSLELYDTETQKF
                     KQLKYLEFDDKNCVGKTIRKVSIDDKTKTICLLVLDCVSETDVSLKIETYDYDMNFLKS
                     YDISDISDDSNELIQGVQFFDFRNNYLIYQNFSMTRCIGYIGNKKLQKSDMIDNIDDTY
                     SMAQTPQKGYDTILSYKGIDSDHKIYSFNTIDKTMKKTTFKPEIKDYTINRISRIGKDN
                     LMIIMFPDNADKKSNLNPRIYFTKLSDLNFQ"
ORIGIN
        1 cgagccttat aaaaaaatac ggtattgagt ggcttttgaa cctgataaaa aaagtttcag
       61 agcttgcagt atctgcattg caggactttt tcagccacat actggttaaa aaattgtcgc
      121 tgagtatcag cgttgcaggt gacgatgcgg ccgacacggc tataaaatac ggcaaatact
      181 gtgccgttgt ttatccggca gtaggcacaa ttgtccgtgt tgtaaaatgc aaaggctacg
      241 gagttgacat aaatccgaat ttttcggaaa aagcagaaac agaaattaac tttgactttg
      301 ccgcaagaat tttcgcattc cgacttatcg gtcttgccgt taagcacgga atcaagggga
      361 ttaaacttct tgcagaagtt aaaaatgatt gatataaata ttgttgaaaa aggagaatgg
      421 ctatggaaca tcctatcggc agtttaatgg ataccacaat ggaaaaaatc aaggaaatga
      481 ttgatgtcaa tactattatc ggcgagccta taacttcgcc tgacggcaca cttatcattc
      541 ctgtttcaaa ggtaagctac ggctttgcgg caggcggttc ggatctgcct accaaaaagg
      601 aaaacaaaga ctgctttggc ggcggcagcg gtgcaggtgt gacaattcag cctgttgcat
      661 ttcttaccgt ttatcagggc gatgtaaggc ttgtttccgt tgacagggaa gaaggtacag
      721 ccgacaagct cgttaatatg attcccgatg ttcttaaaaa agtaaaggga gttttcaaaa
      781 aggataagag cgaatccgca gacgattttt ccgaaatcac acaggacgat attgacggct
      841 gattcgtaat attgcaacac ccctcggcat agatttatgc agggggtgtc cttatgaaaa
      901 aaataatctc gcttgcggtg tgctttgtta tgccgtttgt gcttatgggc gcaaaaactg
      961 cggaggatac tcctcccaca acttctgcac aggcatttgt cctttattgt cccgataaca
     1021 acacagttat ctgttcaaaa aatgcagatg aaagaatgaa gcctgcgagc accacaaaga
     1081 ttatgacatc tctcataacg cttgaggagg cggcatcctg taacagcgaa gtaaccttca
     1141 aacaggaaat ggttgccgag ggcagttcga tgtatcttaa agtcggtgaa aaagtccgac
     1201 tttcggacct tgcgtcagga atgatgatgg cgtcgggtaa tgatgcggcg aatgcggcgg
     1261 catatacgat ttcgggcagt cccgaaaagt tttcacaacg aatgaatgaa aaggcaaagc
     1321 aaatcggtat gacgaatacc aattttgtaa cgccgagcgg acttgacgat gacaaccatt
     1381 actcaagtgc aaaggatatg gctctgctta tgtcatatgc acttgaaaat gacgattttg
     1441 caaatcttac ggctaagaag agcgtgaccg ttgaatttct tgaaccgaaa tcaaagaaaa
     1501 ccgcatatgc aaatcataac aggcttttgt cgctttatcc ctactgtaca ggcggaaaaa
     1561 caggctatac aacggcggca gggcggtgcc ttgtttcctc tgccaaaaaa gacggtgtaa
     1621 cgcttgtgtg cgtcacgctg aatgaccgca acgattggaa tgaccatatt tctctttatg
     1681 attacgcttt tgaaaagtac aggggagttg actgcaagga tgctgacttt tgtgccgata
     1741 ttccgtgcgt gggcggtgat aagaacagcg taacagttac aggtgagaag aacaacacaa
     1801 tcgttttaaa gcgtgaggac tgcgataaaa tcaagaaaaa aatcttcata gacagctttt
     1861 tgtatgctcc gattgaaaag aacgaatcgg ttggcagaat tgaatacaca ctcggcggaa
     1921 agctgcttta taaatgcaac attgttgcag gcgataagat taaatcggat aaaaagagtg
     1981 tgtcaatatt ttcggcaata ggaaatctgt tttcgtgaca gcttaaatat acagaaaatt
     2041 ttattaaaaa ggaatttaca tatggctaaa attgaaccta taagacttca gaaattcata
     2101 gcgcaatgcg gtattgcgtc aaggcgaaag gccgaggagc ttattctcgg cggtcatgtc
     2161 aaggtgaacg gcaaaaccgc aattctcggc gataaggttc ttcctacaga caaggtgttt
     2221 gtaagaggca agaggattgt tgtgccgaag ggcggtaatt accgatatat tatgctcaac
     2281 aagccccgtg gattcattac cacaatgaat gatgagcgtg gcagaaagtg tgttgcacag
     2341 cttgttgaga atgtcggcga gcgagtttat ccgataggca gacttgacaa agacagcgag
     2401 ggtatgcttg tttttacaaa tgacggtgac tttgcaaaca aggttatgca cccgaaaaac
     2461 aatgtttaca agatttacag agtaaccgtt cgaccgtcaa ttgacgagga tcagcttgta
     2521 aagcttgaaa caggcgttga gcttgacggc aggaaaaccg ctcctgcata tgtccatgta
     2581 attcacaagg agcagggcag agtagttctt gaaatgattc ttcacgaggg taagaaccgt
     2641 gaaatcagaa gaatgtgcga ggctgtcggg cttgaggttg caagactaaa acgcacccag
     2701 atcggcggag ttaaaatggg tatgctcaaa cagggcgact ggagagattt gaccgaacaa
     2761 gaggttaaaa aactgcttgc aaacccgttt ttaaacggca aacagcttta attttccgtt
     2821 tttgaaaaat acttccgaaa cggtcaatca aactatttgt taattcgaca ataaattaaa
     2881 ggttttcacg gaataactat taaatgtgtt caaaattgaa atagtacagc gtgtttttct
     2941 tgtacttttg aagattatag agtataatgt attgtgtaga aaattagtat gcacgctcag
     3001 ttttcgtgca tattcaatac atggtattgg aggattttaa gatgagtatt gaaaagatca
     3061 atcaggcaaa ggctgaaatt gccgcaactt ccgcttataa gacaattacg gcgttttttg
     3121 atgcagacag cttttgtgaa attgatgcct ttgcaaaatc cggtgaaggt tttgccgagg
     3181 ttgttgcagg ctttggaaca gtagaaggta tgcctgttta tgcgtttgca cagaacagcg
     3241 acatttgcgg cggtgccatg agtaaggcac aggctgccaa gcttaaaaag ctgtatggtc
     3301 ttgcactcaa gacaggcgct cctgttgtag gtttctatga cagcgttggc ggcagactta
     3361 atcagggtac agagcttctc gcaggttgcg gtgatgttct caatgcggct gcgtcacttt
     3421 ccggtgttgt accgcagatc tcggttgttc tcggtacttg cctcggaaca aacgctctta
     3481 acgccgcaag cgcagacatc gttatcatga gtaaagacgc acagctttca ctttctgtaa
     3541 caggcaagca ttccgacgcc gcttacaatg ctgaaaacgg tattgcctca atcgtttgtg
     3601 acgatgcaga caaggcaatc aaggctgcaa aggaacttat cctttatctt ccgtcaaata
     3661 acctcacaat ggctcctcag tcatttgaag aagctccggc agaggacggt tgcggttgtg
     3721 tagtcagcag aacagttgac ggcaacagca ttgtaaagct cttcaatgat tacggcaagg
     3781 aagcaaatgt tcgtttcgca agactcggcg gtcaggttgt aggtattgtt gttacaaagg
     3841 gcaaggagct tggttgcaag tctgcaaaca aggtagcaaa gtttgttcgt ttctgcgacg
     3901 ctttctcact ccctgttgta acattcgtaa actgcccggg ctttgagtca atcaagtcgg
     3961 caacaaaggc atcagctgct tatgctgagg caacaacagt taagatttct gttgttacag
     4021 gcaaggcaat cggttcaggc tatgttgctc ttgcgggcac aggcgctaat gcagatgttg
     4081 tttacgcact tcccgatgca gttatttcac ctgttaatgt tgaggctgcc gcattcatta
     4141 tggctcccga agttatgaat gttgccacag ataagcaggc tgaggttgct cagaagtttg
     4201 ctgacgagaa tctttctgct tacaatgccg ctcagaacgg ctatgttgac ggtattgttg
     4261 aagaagctca gctccgtcag actcttattt ctgctcttga tatgctctcg ggcaagcgtg
     4321 tttcaacact ttcaaagaag cattcaacta tctgataaat gattacttgt taaaataaaa
     4381 ggggatacta aaaatgaaga atttaagaat tacagttaac ggcacagcat atgatgttca
     4441 ggttgaagaa ctcggtggct cttcagctcc agcagcagcc gctcctgctc cggcagccgc
     4501 tccagctcct gcagcaaagc cggcagctcc cgcaggcgct cagggttctg ttgttgtaaa
     4561 ggctcctatg cccggtacag ttgttaatgt tgttgtttcg gcaggacagg ctgttaaggc
     4621 cggcgatgac ctcgtattta tcgaggctat gaagatggaa actcccgtta aggctccgca
     4681 ggacggcaca gttgcaacag ttgatgttgc aaagggtgag tctgttgact caggtaaggt
     4741 tctcgtaaca cttaactaat caataattcg gagaaaggga tgctgtaaaa tggcaaaaaa
     4801 aatcagagtt accgaaactg ctctgcgtga cgctcatcag tcactcattg caacaagaat
     4861 gacaacagag gaaatgctcc ctgttcttga caaactcgat aaaatcggtt attactcact
     4921 cgaatgctgg ggcggtgcaa catatgactc atgcctcaga ttcttaaacg aagatccgtg
     4981 ggacagactt cgcacaatca gagagcattg ccctaacaca aagctccaga tgcttttcag
     5041 aggacagaat atgctcggtt atcgtcacta tgccgatgac tgcgttgagt accttgttca
     5101 gcgttcaatc gcaaacggta ttgacattat ccgtattttt gatgctctta acgacatcaa
     5161 gaatcttaaa acagctatca aggccgctaa caaagaaggc ggtcatgcac aggttgctat
     5221 cagctacaca acaggtcctg tattcacaga tgaatactat gttgagtatg ctaagagaat
     5281 tgcagacgca ggtgcagatt caatctgtat caaggatatg gctgctcttc ttactccgac
     5341 aagaaccgaa agccttgtaa aggctatcaa agccgctgtt ccggagcttc cgcttcagct
     5401 ccacacccac tacacatcag gtcttgcatc aatgtgtctt ttaaagggtg ttgaggcagg
     5461 tgccgacggc attgacacag caatcagccc actcgctctc ggtacatcac acgcacctac
     5521 agagtcaatg gttgccgctc tttcaggcac agagttcgac acaggtcttg accttaaaca
     5581 gttctctgac atccgtgctt acttcatgac tctccgtgag aagtacatca agtcaggact
     5641 tcttgatcct aagatgctcg caacagacgc taacgctctt atctatcagg ttcccggcgg
     5701 tatgctttcc aaccttcttt cacagctcaa gcaggcaggt aaagaggaca agcttgacga
     5761 agttcttgca gaagtacccc gtgttcgtaa ggattcaggt tatcctccgc ttgttactcc
     5821 gacatcacag attgtcggta cacaggctgt attcaatgta attacaggca agcgctactc
     5881 aatgtgtaca aacgagttca agggacttgt tgcaggtgag tacggtacaa ctccaatgcc
     5941 gattgatcct gaattccaga agaagattat cggtgacaag aagattatca aaggtcgtcc
     6001 tgcagatcag cttgagcctg agcttgataa gctccgcggc gagattgagc agtggattga
     6061 acagcctgag gatgttcttt cttatgcaca gttcccgaag gttgctctcg acttctttga
     6121 aaagagaaga aatgccaagg ttggcatcaa cggcgacaag cttgacaaga aaaatatggt
     6181 tcacccagtt tgatttaata actaaaatta acatttatgc cactttcact atgaaagtgg
     6241 catttttatt tgaacagaat tttttagcta atttttcatc aactatattg tattacatat
     6301 atttttgcgg tataatgaag taaattaaat atctgttgca tataccatta ttacagatag
     6361 aataaataaa agatgaggaa ataaaaatga aaaaattttt aacagtattg atagcatttg
     6421 taatgtgctt ttcggttgta acaacggctt ttgcggctac acctgatgaa gtttctgatt
     6481 cagacttgat ttcagatatt aaacaggcta tgttagatac atattacggt gatgaaaagc
     6541 ctgattttat tgaagtaaga atatatggta cagccagtga cggtggtgtg tatttcgatt
     6601 ttatggatag ttttacacac tggacagatg aagtggaatt cgatataggt gattatactg
     6661 tttcttatcc gagagattgt cccgttttgt tatacaagaa taataaagta tataccttgt
     6721 cagatgccta tgaaacaggt gtaattgatg atgatatgct ctatgaatta tatgtttggg
     6781 gaaatctttg gggtaagata gatgttaccc caaagggtga agatagagct ctcctttcag
     6841 aaataaagcg tgtaattata aataaatatt acaatggcaa agcacctgaa tatttgaatg
     6901 tcgaaattgt tggttctaca agtgatgaaa cagtatgttt tagaaatata ccctttatga
     6961 gtttaggcgt tatgattgaa caaacaattg gcgactatac ttattattat aaccatggcg
     7021 atgatgttat gctttataag aatggcaatg tttactcaat taaagaggct tatgaaagcg
     7081 gagttattga cgatagtatt cttgaagaat tgtcaaaaat gaattttggt ttggaatcta
     7141 ataaaccgaa tacaactgtt cctactgagc ctacaacttc ggttgcaaca gttgacgaac
     7201 ctgtaacagt acccgataca acttctgcaa cttcggcaac aaagcctgtt tcaacaagcg
     7261 acacagcaac aaatgacaca ccaaacaatt cacagaataa cagcggtgct gtacagacag
     7321 gacagaacag cgttgctgta attcttcttg ttgcaatgct tgcaggttgt gcagtaattt
     7381 ttgcaaaacg cagaaattat tttaaataat tcaaaacatc aacagaatat ataaaataaa
     7441 ccgttctcgc ttttgtgaac ggtttattta ttttagctta aaaatttgtg atagtttatc
     7501 aagatgtatt gctttttata tcatttaatg ttacaattaa cttgcataaa aattcagcaa
     7561 aagcttttaa taatgcgtag aatttgaaca aagtgaggga caaatatgaa aaagttttta
     7621 cctatagcca tggcggcggt tatgtcgatg tctgcggttg cggtttcggc agtttctgca
     7681 aatgcggttg aaccacttaa cacacccgtg cagtatgcac aggttgcaag agcaagcttg
     7741 gcaaccccga aaatttcaaa agccgaaagc gtttacggcg gtgtaaagct tacatggaac
     7801 aaagtgaacg gtgcggctaa atacagagtt tactacaagg gtcgtaaagg ttggacacga
     7861 atggtcgata caacttcaac atcatatatc gacaaggatg tttcatcggg caggaattac
     7921 acctatactg taagatgtat ttctgctgac ggaaagagct ttacaagcgg ttatgattca
     7981 aaggggacaa ccgtaaaata tattgccgcc cccgaaattt caaagcttga aaatgtaaac
     8041 ggcggtgtga aaatctcttg gggcaaagta agcggtgcgg ctaaatacag agtttactac
     8101 aagggcagta aaggctggac acgaatggtc gatacaactt caacctcata tattgacaag
     8161 gatgtttcgt cgggcaggaa ttacacctat actgtaagat gtatttctgc tgacggaaag
     8221 agctttacaa gcggttatga ttcaaagggg acaatcataa aatatattgc cgcccctgaa
     8281 atttcaaagc ttgaaaatgt aaacggcggt gtaaaaatct cttggggcaa agtaagcggt
     8341 gcgactaaat acagagttta ctacaaaggc agtaagggct ggacaagaat ggtcgataca
     8401 acttcaacat catatatcga caaggatgtt tcatcgggca gaaattacac ttatactgta
     8461 agatgtatta catcagacgc aaagaaattc acaagcggtt ataacccgac aggcaagtcg
     8521 gtaaagtatg ttgccacacc gaaaatttca aaaactgagg tcacatatga cggcgtaaag
     8581 ctgacatgga acaaggtcgc aggtgcagaa aaatatcgtg tgtattacaa ggacagaaac
     8641 ggttggacaa agcttgccga tacaacaggc acgactatgc ttgatatgaa tgttgtttca
     8701 aaggaatttg atttaagcgt tgatgatatt tattacacgg ttcgttgtat cagcaaggat
     8761 gccaagagtt ttacaagcgg ctacgattca aagggtacgc ctattggcga tcatcaggat
     8821 tgtcccgaaa tttacagcat tggtgcagta aacaacggtg ttgaaatgca ttggacggga
     8881 gatgcgccaa agttccgtgt ttatattaaa gaaaacggtt cttggaagaa gatagcagaa
     8941 acttatgaca actattatgt tcacaagggt gcaaggtccg gcagtaacac ttatacggta
     9001 agaggtgttt caaaagacgg taaaaagttt actacgatgt ttaacccaac cggtgtaaca
     9061 tacagatata agacatctga taaaacaagg gacgcttata tcaattatat gatgaatcat
     9121 cagagtgaat ggatgccaag tttgggaagt aatcacaatt tgtcaggtgt tatgtttttg
     9181 gatttcgact ttgacggagt tccggagctt gttgcacaaa aggctgattc caatgagtat
     9241 agtttccatt ccgttgttta caaatttgaa gacggtaagt taaaaagagt gggaaatgtt
     9301 aacgacggtt ttgcgatata ctataataaa actgccaaaa agtatgaggt tcacgaccta
     9361 aagatatctt taaatgtaga tgacggttac tattggtcgg gtaattcaat aatcacatac
     9421 gacggagaga atctttttgc aaatatgtat tcggcacgag gcgtaggcga agaatcaaat
     9481 aataatattt attataatta ttttgacggt aatgacaaaa atatttcacg ggcaaaatat
     9541 aacgaaatta accttaaaca gtttaataat tgcgtaaatg cacatatgtt taccaaattt
     9601 attgtgacag gttatggtga taacagcgta tggagtgaga atactacagc tgagaataag
     9661 cagtctttgc ttgacgctta taattctttc tcctatgaga agtattgatt atttaaaaat
     9721 taataagttt taactgcaaa agggttcagc cgtaaaaaac tgaacccttt tattgcacaa
     9781 caaaaaaacg gttcagccaa attgactgaa ccgttaatct gtactatgtt aagcttggga
     9841 acaagtagtt gtaaattatc acaaactacc tacacgaact gcgggcgatg tactcgcaaa
     9901 aagggtagct tgaaaatcaa gctaccctaa attcgtacta tgtaacgctc gggtgacaga
     9961 aatttgaata tatcaaacta acttcacgaa ctaaaaaaca ttagttgttg atgagcttat
    10021 cttcgtcaga ccagctgtag agctttctaa cttccttacc gaatacttcg gcaggagctt
    10081 cggcagcgag ctttctcata gccttgaagt gaacctgtga accggcatcg ctcatgtcaa
    10141 ggaggaagtc cttagcaaat gtaccgtcct gaatgtcaga aagaaccttt ctcatagcct
    10201 tcttagtatc ctctgtgatg atctttggac ctgtgatgta gtcaccgtac tcagctgtgt
    10261 tagagattga atatctcatg cctgcaaaac ctgactgata gataaggtca acgatgagct
    10321 tcatctcatg gatacactca aagtaagcat ttcttgggtc gtaaccggca tcgcaaagtg
    10381 tttcaaaacc tgcctgcata agtgcgcaaa caccgccgca aagaacagcc tgctcaccga
    10441 agaggtctgt ttctgtttct gttctgaatg ttgtttcaag aacgcctgct cttgcaccgc
    10501 cgataccgag tgcatatgca agtgcgagat ccttagcctg acctgtagcg tcctgctcaa
    10561 cagcaacgag gcaaggtaca cccttaccaa cctgatactc tgaacgaact gtgtgacccg
    10621 gtcccttagg agctaccatt gtaacatcaa catcctttgg aggcttgatg caaccgaagt
    10681 gaatgttaaa gccgtgagcg aacataagca tattgcctgc ttcgaggttt ggctcgatgt
    10741 cgttcttata aagagctgcc tgcttttcat cgttgataag aatcatgatg atgtcagcct
    10801 gctttgcagc ctctgccgat gtatatacct taaagccctg agcttcagcc tttgcccagc
    10861 tcttgctacc ttcgtaaaga ccgatgatta catcgcaacc tgaatccttg aggttgagag
    10921 cgtgtgcatg accctggctg ccataaccga taatagcaat tttcttaccc ttgagaaggt
    10981 caaggttgca atctgactga tagtagattg gtgctgtcat gttctttgtg tagtctttca
    11041 tattaaagtc ctccttaccg caaacgcggc atataaatta gaatatatgc taactgtaag
    11101 attaaacgga aaccgaagct gtgcctctgt caatggcaac agtacctgtt cttacaatct
    11161 cacggatacc ataaggcttg agtaagtcaa caagcgtgtt gatgcggctt gcacattcgc
    11221 agtactcaac ggtaactgac gaaggggata catcaacgat tttcgcctgc ataatttcaa
    11281 ccgttttgac aatttcggct ctttttgagg cggcgcagtg aaccttgatt aatacaagct
    11341 cacggctgat aaattcgccc tcgttaagcc tttttacctt aataacggga atgagcttgt
    11401 tgagctgttt ttcaagctgt tcaacaatgt actcgtcacc gtttgcaacg attgtgattc
    11461 gggaaaccga cgggtcctga gtaacaccta ctgcaagtga gtcgatgtta aaacctcggc
    11521 gagagaaaag tcccgaaatc tttgaaagaa cgcccgcctg attttcaaca agtattgata
    11581 atgtatactg cattttatca cctcattaaa ttgacggagt gtcggggtga acatcgcaaa
    11641 caagaatgaa cggtttttca gaatcaacaa tacccttgat gatgttttcg gcttccttgt
    11701 ttgaatgagc ctctgcatgg tcaatgccgt aagcatcggc aatcttcaag aagtcgggat
    11761 caccgttgag aattgttgcg gagtgtctgc cgccgtagtg tttgtcctga agttcacgaa
    11821 ccattccgag tcgtgcgttt ttcataatga tgattttaat tccgagctga ttgcctgcaa
    11881 tagtcgcaag ctcattaagc cccatctgaa aactgccgtc accgcagatt acaataacat
    11941 cacggtcggg tcttgcaaac tttgcaccga ttgcagcggg aattgagtaa cccattgtac
    12001 ccataccgcc tgttgtgagg aatctgccct cacgaatacg gaagttgttt gcacaccaga
    12061 tttgattttg tcctacatcg gcaacgagaa ttgcctttga gcggaacatc gcactgagat
    12121 gaccgacaag tgttctcggc tcaacaaagc cgtcaaatac gggaggctca cggtaaaggt
    12181 cttttttcca gttctttacg gtttcgctcc acattgttgt aaccttgtaa tcgccgatac
    12241 tgtcaagcag catattgatg acatttttca tatcgcctac aatcggaatt tccgttttaa
    12301 cattcttacc gatttcagca gggtcaatgt caatgtgaat tacctttgtg ttttcactca
    12361 tctggtcggg agctgcaaca gctctgtcac cgagtcttgc accacatacg attacaaggt
    12421 cggcttcgtg aagagcacgg ttggcaacag ccttgccgtg agtgccgagc attccgagat
    12481 aaagctcatg ctcgctgggc ataacaccga tgcccatcat agttgaaata acggggatac
    12541 ccgtagtttc tgcaaatttt tgaagtttaa gcttgatacc cgaactcagc acgccaccgc
    12601 ctgatacgat aacaggacgc ttgcttgcgt tgatggcctc aacagccttt ttaacctgaa
    12661 ttgcgtgtcc cttggtgttc ggcttgtaac cgataatgtt tacgctttcg ggatattcaa
    12721 aactttcaat ttcattttcc tgaatatcaa cgggaatgtc gataagtaca ggaccgggtc
    12781 tgccggttga ggcaatatgg aaagcctctt tgaaaactct cggaaggtct tctgttttgc
    12841 tgacgagata actgtgcttt acaaacggtt cacaagctcc tgtgatgtca gcttcctgaa
    12901 agacatctct gccgagaagg tcggaacgaa cctgacctgt aatggcaaca atcggaatag
    12961 agtccgtata ggcggttgca atgcctgtga tgaggttggt tgcaccggga ccggaagttg
    13021 ccacgcaaac accgggacga ttactgcatc ttgcatagcc gcttgccgca tgagcagcgt
    13081 tctgttcctg acgaacaaga atgtgggtaa tgctcgaatc gtaaacttta tcgtaaaatg
    13141 ggcagatagc cgcaccggga taaccaaaga ctatgtcaac gccctcggct tccaaacatt
    13201 ttaccataat ttcagcaccg ctgatcatta tgttttgtcc ctcctatcct tatttattgt
    13261 gagcaaaagg tgttttgtaa cattaaatat acctttttgc tttaccgcta attatacaat
    13321 aaatacctta aaaagtaaag agcagtattg cccataaatt aaattttttg caggattttg
    13381 acagataatt tgcaaaatgg attttaattg atttttaccg cctgtttact gaaaatttaa
    13441 gtcgcttagt tttgtaaagt atattcttgg attaaggttg ctttttttgt ctgcattatc
    13501 agggaacatt attatcatca aattatcttt tcctatccgt gatattctat ttatagtgta
    13561 gtctttgatt tcaggcttga atgttgtttt tttcattgtt ttgtcaatgg tgttaaatga
    13621 gtatatcttg tggtctgaat caattccttt atatgataaa attgtatcat atcctttttg
    13681 tggagtttga gccatagagt aggtgtcgtc aatgttgtca atcatatcgg atttttgcaa
    13741 ttttttgttc cctatataac ctatacatct tgtcatacta aaattttgat agataaggta
    13801 gttgtttcta aaatcaaaga actgtacacc ttgaatcagt tcatttgaat catctgaaat
    13861 atcggatata tcatagcttt tgagaaaatt catatcatag tcataggttt ctatttttaa
    13921 agaaacatct gtttccgaaa cacagtccaa aaccaagagg cagattgttt ttgttttgtc
    13981 gtcaattgaa acttttctta tagtttttcc tacacagttc ttatcatcaa actctaaata
    14041 tttcagttgt ttaaactttt gcgtttcggt gtcatacagt tccaaagaag taccgttgtt
    14101 taatactttt gtaattatga caagattgtc tgctcctgta acagtgtcat atggaaatcc
    14161 gcctttgtca gaaaatacag tagtcatttt gtttttatta aggtctatat caataaattc
    14221 aagggttctg ttttcttcat ctgtaatgtc acccgtgctt gccataaaac ataagtgatt
    14281 atttacatac gctttatcgt taatttgcat tgtccagtct tttattgagc cgagttttat
    14341 actgctcttt ttgtctaaat agtatctgta gtattctatt tcattcggag aagtttcgtt
    14401 gatttttgaa tatatgagtc catcctcagt tggcataagt gcatcgaaaa gatttaaatt
    14461 atcaatcttt ttatcgttat agtaaatctc caaatcgtaa ttaaattctg tttcagaatc
    14521 tgtatctgaa tcaagagata aat
//
