LOCUS       c00074_gnlPro..        13927 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GABJAGOC_74.
ACCESSION   c00074_gnlPro..
VERSION     c00074_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:58:56
            Original ID  :: gnl|Prokka|GABJAGOC_74
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13927
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13927
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6631:10869]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6632..10869
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13927
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13927
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             375..695
                     /locus_tag="ctg74_1"
                     /transl_table=11
                     /translation="LPELNIEALQKLCDDKSVIWSVHALKRLQERGIYRDDVFNAIHTG
                     KIIEQYPDSYPYPACLVLGVSTNNEYLHIVAGCNGNVVCIVTAYFPDSDKFESDSQTRK
                     EK"
     CDS             698..931
                     /locus_tag="ctg74_2"
                     /transl_table=11
                     /translation="MTCFYCKGDLKPSTTTHFVDLKKCIVIVKNVPCLECSKCGETVFT
                     DEVAKRLDDIVKTVSSLMTEIAVVEYTSDKVA"
     CDS             1425..1622
                     /locus_tag="ctg74_3"
                     /transl_table=11
                     /translation="MAENKNSRARIEANNRYNAKAYDRINVAVPKGRKDIIKAHAEKNG
                     ESVNGFVNRAINETMQRDGE"
     CDS             1919..2440
                     /locus_tag="ctg74_4"
                     /transl_table=11
                     /translation="MGEKYYWVLGFCCGFIAVVIVTLIIANIKRKKNTYTEYDERQVLA
                     RGRAYKSAFFVLIGYIIACALVNVLEINWAELSVQMFIGLFLSTAVFVGISIFNDAYFT
                     SNKGRKSLLGVLAFIAGAEYLGIAFGKKTFVTNGIANLDIIPIIVTIWAISIFVMVVIK
                     TIIDKKAVEE"
     CDS             2437..2631
                     /locus_tag="ctg74_5"
                     /transl_table=11
                     /translation="MKNLRLKSARAAKDLSQQQLAELVKVSRQTISAIEKGDYNPTINL
                     CIAICKALDKTLDELFWEE"
     CDS             2845..3537
                     /locus_tag="ctg74_6"
                     /transl_table=11
                     /translation="MIYSKEVENMCTVAKGPKHGPAPIPEEGKWVKSYDIKDISGLSHG
                     IGWCAPQQGACKLTLNVKDGIVEEALVETIGCSGMTHSAAMAAEILPNKTLLECLNTDL
                     VCDAINTAMKNIFEQLVYGRSQTAFSEGGLPIGAGMEDLGKGLRSQVGTMYSTNAKGVR
                     YMEMAEGYVLKTALDENDEVIGYQFVKLGKMLEDIRHGVEPNEAYKNNIGQYGRFDGAA
                     KYIDPREE"
     CDS             3559..4563
                     /locus_tag="ctg74_7"
                     /transl_table=11
                     /translation="MAVTFEGMERRMPKIEKCLAEYGIANLEEARKICNDLGFDPYDIV
                     KGVQPIAFENAGWAYTLGCAVAVKKGAKTASEAAEAIGIGLEAFCIPGSVAEQRNVGRG
                     HGNLGAMLLRDETKCFAFLAGHESFAAAEGAIGIARNANKARKEPLRVILNGLGKDAAY
                     IISRINGFTYVKTQFDYFTSELKIVEERAFSDGERAAVRCYGADDVREGVAIMQHENVG
                     VSITGNSTNPTRFQHLVAGTYKKWANENGVKYFSVASGGGTGRTLHPDNMGAGPASYGL
                     TDSMGRMHGDAQFAGSSSVPAHVEMMGLIGMGNNPMVGATVACAVAVYEAVNK"
     CDS             4678..4950
                     /locus_tag="ctg74_8"
                     /transl_table=11
                     /translation="MQKNIKLNDSAAPIVMAEFFMHFCFNEFMFTDILYSAYVTYLQVL
                     FKPKESTDYSNSLLFQLVKLFNMLHALVAVENVFCPFTVNFKKAL"
     CDS             complement(4849..5547)
                     /locus_tag="ctg74_9"
                     /transl_table=11
                     /translation="MPEKKITKAIVCPMCGEMSKADVYTSINPSVTKGVRRRALDGELF
                     AWKCPSCGYSARLTYPILYNDMKNRFMVYFIPKIDHFQLCDNELEEKYSNLRNISKRIV
                     PTFNSFKEKIFIFESGLDDMSVELTKLAISQTVSKKLNGAEIHDGYLSMYDRERNTMGF
                     TYFTGEKHTPYVQTARLEIYVKSKKIVDSLAYKDKKLKGFLKIDREWAENILYRYKRMK
                     HIEKLNKLKE"
     CDS             5692..6345
                     /locus_tag="ctg74_10"
                     /transl_table=11
                     /translation="MCQSVCAKAVLKEKFTMTILDSVKGTVNTAVDTISSVAQTIVEKN
                     RTNAKLNRLRLVMKSESELMNRAYIALGKIMYDSRKKGTEINDAECEKLLKVIDTSKAK
                     IAKARECYRKIVNSSNDIFYGNPEVAPEVKEDDIVDITVACSNEGDYKTSPFKEEKPVE
                     KQPEAVTEEKAEPEHLTNICDLKAELEAKREEGFSESADSDEADDGEAPHGELF"
     CDS             6632..9535
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_11"
                     /sec_met_domain="HGD-D (E-value: 5.6e-18, bitscore: 55.6,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 6e-39, bitscore:
                     123.9, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKLGLDIGSTTIKCVVLDDENKLIYSTYERHYSRITEKIAEILAL
                     VRTRIDGVENASVALSGSAGMGVAESVGVDFIQEVYATRVAANTFIPGTDVIIELGGED
                     AKILFLTNGLEVRMNGTCAGGTGAFIDQMATLLNVKLEDMDELAKQHEKTYTIASRCGV
                     FAKTDIQPLLNQGARKSDIAESIFNAVVSQTVAGLAQGREIEGQIVYLGGPLTFMSELR
                     NCFDRTLGTKGICPENSLYYVACGAALCAEKTIDFDEVIEKVKNYRGSGNFAFNQPLFK
                     NEEEYRKFCDRHAKADVKQKELKGYTGKAYIGMDAGSTTVKGVVLNDDGELLYSKYLPS
                     KGNPVEIMKQFLDEVYEINPEINVVSSAVTGYGEDIVKNAFAVDYGIVETIAHFTAAKY
                     FMPDVEFIIDIGGQDIKCFKIHNGAIDNIFLNEACSSGCGSFLQTFANALGYEIADFAK
                     LGLFAKRPVDLGSRCTVFMNSSVKQAQKDGATIEDISAGLSLSVVKNALYKVIRASSPD
                     ELGKRVVVQGGTFLNDAVLRAFEQEMGVEVVRPNIAGLMGAYGAALYAKKKSKGVGKST
                     ITDKKGLDEFVHEIKVANCGMCNNNCRLTINSFGKGRKFIAGNRCERPITKKAPANDMN
                     MYAYKLNLIDSYKPVEGIRGKLGIPMALNMYELYPFWYRFFTELKFEVFHSPYSTRKLY
                     QRGQQTIPSDTVCFPAKLVHGHIQTLIDMGAETIFYPCLSYNFDEHLGDNHYNCPVVAY
                     YPEVIKNNMKDIRKVHFIKEYFGIHRPNDFPKKAYERLSFHFPDLTLNEVRNAAKLAYQ
                     EQENYRKKVIDKGNEIIAKAEKEGKKIFVLAGRPYHIDPEINHGIDRLISGFDVAIVSE
                     DVISPRVEHFRTHVLNQWTYHARLYAAAKYVTTRKDMELVQLVSFGCGVDAITTDEVRE
                     ILESKNKIYTQIKIDEITNLGAVKIRIRSLLAALEND"
     CDS             9535..10869
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_12"
                     /sec_met_domain="HGD-D (E-value: 8.1e-28, bitscore: 87.9,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGNSVMAELKYDKKTGRLLFTKQMKKEYTILMPNMAPIHFKILE
                     KVFNYYGYKSDLLNTTGPEIAQTGLKYVHNDTCYPALLVIGQFINALQSGKYDVHKVAL
                     MITQTGGGCRASNYIFLLRKALKKAGFEFVPVISLSFGMEHNSGFSLTLPLIRRFVGGL
                     VYGDQLMLLSNQTKPYEVNKGESMALVDEWTDKISDMLIQGKGYTLEEIDETLDKITKS
                     FTKIELNKVPKVKVGIVGEIYVKYSKMANNGLEDFLADQDCEVCIPGLMGFASFKVDNR
                     IEDYKMFGGSRVKYKFCMMLLNYLTKLEGLMVDAAEKYGFVPPHRYAHTKELVNGVIGY
                     GSKMGEGWLLTAEMIELADTGYENIVCTQPFGCLPNHINGKGAIRKIKEIRPNANIVTI
                     DYDPGAPKVNQENRIKLMLAVGKEELRKKLEAEKNGEKAESSEKK"
     CDS             11013..11810
                     /locus_tag="ctg74_13"
                     /transl_table=11
                     /translation="MKKRLKGFFQRLARWLNVREMRQHKVKAGVYIIIRLILVSLLTAG
                     ILNGKWENVMTCVLTLGLLMLPLFIDRKLSVALPSVLETIVVLFVFAANVMGELGAFYE
                     KIPIWDSLLHAVNGFICAGVGFGLTDILNRSERVKLSLSPMFVCLFSFCFSMTVGVVWE
                     FFEFGSDMLFEKDMQKDTVITAIHSGLISGKPNVIMHIRDITSTVVNGENLGINGYLDI
                     GLIDTMKDLLVNFVGAAVFDTIGWFYLKGRSAGFLRNFIPRKK"
     CDS             complement(12050..13789)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trypsin_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1057:Trypsin-like peptidase (Score: 122; E-value:
                     1.3e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg74_14"
                     /sec_met_domain="Trypsin_2 (E-value: 2.9e-38, bitscore:
                     122.0, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNFDNNNMGGFEPQKPFTERPVQNNNMNTEQTIPVSEPETQEEQ
                     AQNVQPQNGNTPYGDYIFGNNNQNTANDANPTENVPPYQQNQNPNPNTSAQPWQYGYGQ
                     YPYSGQNPQYNQNNQQYGQYQNNTGYNQNVPPYQQNMYGQPPYGNNGTYNQQYNPQMFA
                     QYPQKKTKGGIIALIIVLCSLLTIGFIGMMVYGFSADIKEDLNNDRSDSGNSFRVPKED
                     STTPFETLPDTSSQSKTHDESDYSDKVNKDYSGMKLESNPKDTKTNDSYTAAKASEKVS
                     DSVVGILCYSDDVPDQADTKTASSQGSGIIFSQDGYVITNAHVIGNSKTAYAIRVVTSD
                     GKVYKAGVVGYDSRTDIAVLKMDDAKGLTPATFGDSSQLEVGQDIIVVGNPGGLDYQNT
                     TTKGVISALDRKLSTSSLTKYIQTDAAINPGNSGGPLVNYYGQVVGITTSKIVSETYEG
                     MGFAIPSQTVKNIVDTLVKNGYVEGRVKIGISGIAVTSDQASNYNIPQGIYVQSIVSGG
                     PCDGTNLKEGDIITEVDGETITSFADVYAILETHKPGDKIKVKYYSSSSGDGEVEITLQ
                     EDK"
ORIGIN
        1 gttggatttt tactgttttt tatatcaatg atttggctgt taatgtccaa aattttgcta
       61 gattaacatt ataaaggttg caaccttaca attaaatatg ctgatatagc tcagtaggca
      121 gagtgcgtcc ttggtaagga cgaggtcacg ggttcgaatc ccgttatcag ctccataaaa
      181 gggtattggt taaaaagacc gatacctttt tattgttgtt tagaaaacaa taccgttacc
      241 aaatccaaac tgattaatat tattcttgta caatctatct tgatatgcta caataaagtt
      301 gtaaagaatg gttgcgaatt agttgcgaat aaatacacaa atcaaacaca ccatagacag
      361 aggaggtgac aagcttgcct gaattaaata tcgaagcatt acaaaagtta tgtgacgata
      421 aatctgtcat atggtctgtg cacgctctga aacggttaca ggaacgagga atataccgtg
      481 atgatgtatt caatgcaata catacgggca aaataataga acaatatccc gacagctatc
      541 catatcctgc ttgccttgtt ttaggtgtaa gtacaaacaa tgaatatttg catattgtgg
      601 caggttgcaa cggaaatgtt gtttgtatag taactgccta ttttcccgat tcagataaat
      661 ttgaaagtga ttcacaaacc cgaaaggaga aataacaatg acttgttttt attgcaaagg
      721 tgatttgaag ccaagtacaa caacacattt tgttgatctt aaaaagtgca ttgtaatcgt
      781 aaagaatgtt ccgtgtttgg aatgttcaaa atgcggtgaa accgttttta ccgatgaagt
      841 ggcaaaaaga cttgatgaca ttgtaaaaac cgtaagcagt cttatgaccg aaatagcggt
      901 tgttgaatat acatctgaca aagtagcata attccacaag gcaagctctg aaatatgggc
      961 ttgtcttttc ttttgcctgt ggggttctgc tatgccgctg cctacgcttg catatactgc
     1021 aattgcgttg cggtcatact gattatcgct ttcccctttc cttatcctgt gactatatta
     1081 tactacaatg tttaagcgta taatttgtgc atattggtac ttgttaagtg taaagaggtg
     1141 cgctataata atatttgtaa aggaacggtg gcggctgttt cgactccctt gcgaaagggg
     1201 gtgtattcca atggcagaga ttacatactt atttgttctc gcaattgttt tcgtggcttt
     1261 taatgaagtc attaagaata taaagaaata accgccctgt agtcgcaata cagagcggtt
     1321 tttaataaaa aatacgcaaa tgcgaaacag ctaaagccgt tccttttcac ctatattata
     1381 caacaacaat aatttgatgt caatagattt taggcggtga agaaatggca gaaaataaga
     1441 acagcagggc gagaattgag gcaaacaacc gatataacgc taaagcatat gaccgtatca
     1501 atgttgccgt gccgaaaggt cgaaaagata ttatcaaagc ccacgcagaa aagaacggcg
     1561 aaagcgtgaa cggctttgtt aatcgtgcta ttaatgaaac aatgcagcgt gacggtgagt
     1621 aattccacaa ggcaagctct gaaatatggg tttgtcttgt tttgttttag ttgacagttt
     1681 ttttaacgga tttaattttc caaaacagcc aaatgaaagt atttttgaaa ttatgtaaaa
     1741 tatacttgac aataagtagc ttttaatgta ctataatggt acagaaagct ttttgtacgc
     1801 attgtggatt ttttaagtat tcacatctaa acacataaaa tttttttaat attatttgcg
     1861 gattatcggt tggacgaata aatctgcaaa ttggctgatt tatttgggag atgttattat
     1921 gggagaaaaa tactattggg tgcttggttt ttgttgcggt tttattgccg tagttatcgt
     1981 aacgctcatt atcgcaaaca ttaaaaggaa aaagaacact tacacagaat acgatgaacg
     2041 acaggttctt gcacggggca gggcgtataa atcggcattt tttgtgctta tcgggtacat
     2101 aattgcctgc gctttagtta atgttttgga gattaattgg gctgaactca gcgttcaaat
     2161 gttcatagga ctgtttcttt caactgccgt attcgttgga ataagcattt tcaatgacgc
     2221 atattttaca tcaaataaag gcagaaagag tcttttaggc gttttggcat ttattgcggg
     2281 agcagaatat ttgggaattg ctttcggcaa aaaaaccttt gttacaaacg gaatagcaaa
     2341 tcttgacatt attcctatca ttgtaacgat ttgggcaata agtatttttg tgatggttgt
     2401 catcaaaaca ataattgaca aaaaggcagt tgaagaatga agaatttaag attaaaaagc
     2461 gcccgtgccg caaaggattt gtcacagcaa cagcttgcgg aacttgtaaa ggtgtcaaga
     2521 cagacaataa gcgcaattga aaagggcgac tacaatccca caattaacct ttgcatagca
     2581 atatgtaaag cgcttgacaa aacccttgac gaattgtttt gggaagaata agtaaacttt
     2641 aacggcaatc ggtgattcgt ttcacggttg ccgtttttat ttttaccgtt tcaaaatcaa
     2701 acggcaaatt gccacgggaa atattacaat gtgggggaat tgtaaaaatt aacgaaaaat
     2761 gcttgaaaaa tgtcgggtta agccgtataa tataggtgtt tgaggatttc ggactcatac
     2821 aatttattga aaggagaagt acacatgatt tattcaaaag aagttgaaaa tatgtgcact
     2881 gtagcaaagg gacctaagca cggtcctgca cctattcccg aagagggcaa atgggtaaaa
     2941 tcttatgaca ttaaagacat ttcaggtctt tcacacggca ttggctggtg tgctcctcag
     3001 cagggtgcct gcaagcttac acttaatgtt aaagacggta tcgttgaaga ggctcttgtt
     3061 gaaacaatcg gttgttcggg tatgactcac tctgcagcta tggcagcaga aattcttcct
     3121 aacaaaacac tccttgagtg ccttaacaca gacctcgttt gtgacgctat caacacagct
     3181 atgaagaaca tcttcgagca gctcgtttac ggcagaagcc agacagcttt ctcagagggc
     3241 ggtcttccga tcggcgcagg tatggaggat ctcggtaagg gtcttcgcag ccaggttggt
     3301 acaatgtaca gcacaaacgc taagggcgtt cgttacatgg aaatggctga aggctatgtt
     3361 ctcaagacag cacttgacga gaacgatgaa gttatcggct atcagttcgt aaagctcggc
     3421 aaaatgctcg aggacattcg tcacggcgtt gagccaaacg aagcatacaa gaacaacatc
     3481 ggtcagtacg gtcgttttga cggcgcagct aagtacattg accctcgtga agaataattc
     3541 ggtaaggagg acaccataat ggcagtaaca tttgaaggta tggaaagaag aatgcctaaa
     3601 attgagaagt gccttgccga atacggtatt gcaaatcttg aagaggcaag aaaaatttgt
     3661 aacgatctcg gttttgatcc ctacgacatc gtaaagggcg ttcagccgat cgcatttgaa
     3721 aacgcaggct gggcttacac actcggttgt gcagttgcag ttaagaaggg cgcaaagact
     3781 gcttcagagg cagcagaagc tatcggcatc ggtcttgagg ctttctgtat tcccggctca
     3841 gtagctgagc agagaaatgt tggtcgtggt cacggtaacc tcggcgcaat gctcctcaga
     3901 gatgaaacaa agtgctttgc attcctcgca ggtcacgaaa gctttgcagc agcagagggt
     3961 gctatcggta tcgctcgtaa cgctaacaaa gcaagaaaag agccgctccg tgttatcctt
     4021 aacggtcttg gcaaggacgc tgcttacatt atttcaagaa tcaacggctt tacatatgta
     4081 aagactcagt ttgactattt cacatcagag cttaaaatcg ttgaagagag agctttctca
     4141 gacggtgaaa gagctgcagt tcgctgctac ggcgctgacg atgttcgtga aggtgttgca
     4201 atcatgcagc atgaaaatgt aggtgtatct atcacaggta actctactaa cccgactcgt
     4261 ttccagcacc tcgttgcagg tacatacaag aagtgggcaa atgagaacgg cgttaagtat
     4321 ttctcggttg catcaggcgg cggcacaggc cgtacacttc accccgataa catgggtgca
     4381 ggtcctgcat catacggtct tacagactca atgggcagaa tgcacggtga cgctcagttc
     4441 gcaggttcat cttctgttcc tgctcatgtt gaaatgatgg gccttatcgg tatgggtaac
     4501 aacccgatgg ttggtgctac agttgcttgc gcagttgcag tttatgaagc tgttaacaag
     4561 taattaccaa tcttttcaat aaattaaaaa ggggtcggct ctttgagtcg atccctgatt
     4621 tttttgtgca acgaaaatcc ccgattgtat cggcatttta acaagttgga attgcaaatg
     4681 caaaaaaata ttaagctgaa tgattccgcc gccccaatcg taatggcgga attttttatg
     4741 catttttgct ttaacgagtt tatgtttacg gatattcttt acagtgcata tgttacttat
     4801 ttgcaggtgc tttttaaacc aaaagaatcg actgactaca gtaacagctt actctttcag
     4861 cttgttaagc ttttcaatat gcttcatgcg cttgtagcgg tagagaatgt tttctgccca
     4921 ttcacggtca attttaagaa agccctttaa ctttttgtcc ttatacgcaa gcgaatcgac
     4981 aattttcttc gatttaacat aaatttcaag tcttgctgtc tgaacatacg gcgtatgctt
     5041 ttcacctgta aaatatgtaa atcccattgt gttgcgttca cgatcgtaca ttgaaaggta
     5101 tccgtcatga atttccgcac cgttaagctt ttttgaaacc gtttggctga ttgcaagctt
     5161 tgtaagctca accgacatat cgtcaagtcc cgactcaaag ataaaaattt tctccttgaa
     5221 cgaattgaag gtcggaacaa ttcgtttgct tatgttgcgg agattgctgt atttttcttc
     5281 aagctcattg tcgcagagct gaaaatgatc aattttggga atgaaataca ccataaaacg
     5341 attcttcata tcattgtaga gaatcggata tgtgagcctt gcggagtatc cgcatgacgg
     5401 acatttccac gcaaaaagct caccgtcaag cgctcttctg cgcacaccct ttgttacgga
     5461 cgggttgatg ctggtgtaaa catcagcctt gctcatttca ccgcacattg ggcagacgat
     5521 tgccttggta attttctttt caggcatcca aaccacctct ttaacactct atgaaactaa
     5581 ttatagcaat tgaccgtgat tttaacaagt aaattttaaa aaaatgttga ttttatcaaa
     5641 aaaatctgtc ataataatag aaataagttt aatattattc gccacggcag aatgtgtcag
     5701 agtgtttgtg ccaaagcggt tttaaaggag aaatttacta tgacgatact tgacagtgta
     5761 aaaggaacag taaatacagc cgttgataca atttcatcgg tagctcagac aatagtagaa
     5821 aagaacagaa caaatgcaaa gctcaacaga ttaagacttg ttatgaaaag cgaaagcgag
     5881 cttatgaaca gagcatatat tgctctcgga aagattatgt acgacagcag aaagaaaggc
     5941 actgaaatta atgacgccga gtgcgaaaag cttttgaagg ttattgacac ttcaaaggcc
     6001 aaaatcgcaa aagcaagaga gtgttacaga aagattgtca acagctcaaa cgatattttc
     6061 tacggcaatc ccgaggttgc tcccgaggtt aaagaggatg atattgttga tattacagta
     6121 gcttgctcaa atgagggcga ctacaagacc tctcctttta aagaggaaaa gcctgttgaa
     6181 aaacagcccg aggctgttac cgaagaaaag gcagaacccg agcatcttac aaacatctgc
     6241 gacctcaagg cagagcttga ggcaaagcgt gaagaaggat tctccgagtc cgcagattca
     6301 gacgaggcag atgacggtga agctccccac ggtgaacttt tctgataatt ttaaatactt
     6361 aaagctgaag acctgccgat ttcggcaggt ttttctgcat ttttaagata tattaaagtc
     6421 ggaacaatgc tccgccttgc ttttgagggc aaattatatg cagtagatta tacattatgc
     6481 cctttatgtg tattgaattt ttgtgctaaa aatggtaaaa ttcatcaaag gtggaaatat
     6541 tccgaattag aattatttac ttggcaaaaa atactataat taattagata tgcacaatga
     6601 gattactatg tattgatttc ggaggcacaa gttgaaatta ggattggata ttggctcaac
     6661 aacaataaaa tgtgttgtgc ttgacgacga aaacaaatta atatacagca catatgaaag
     6721 gcattattcc cgaattacgg aaaagattgc agaaattctt gcacttgtac ggacaaggat
     6781 tgacggcgtt gaaaatgcct cggtggctct ttcgggttct gccggaatgg gtgttgccga
     6841 gtctgtcggc gttgatttta ttcaggaggt ttacgcaaca agagttgccg ccaatacttt
     6901 tattccgggt acagatgtta taattgaact cggcggtgag gatgccaaaa tattgttcct
     6961 tacaaacgga cttgaggtaa gaatgaacgg tacctgcgcc ggcggtacgg gtgcgtttat
     7021 tgatcagatg gcaacacttc tgaatgttaa gcttgaggat atggacgagc ttgcaaaaca
     7081 gcacgaaaag acatacacaa tcgcatcaag atgcggtgtg tttgcaaaga ccgatattca
     7141 gccgcttctt aatcagggtg cgaggaagag cgacatcgca gagagtattt tcaatgcggt
     7201 tgtaagccag actgttgcag gtcttgcaca gggcagagaa attgaaggtc agattgtata
     7261 tctcggcgga cctcttacat ttatgagcga actgagaaat tgctttgacc gcacgctcgg
     7321 aacaaaggga atctgtcctg aaaattcact ttattatgtt gcctgcggtg cggctttgtg
     7381 tgccgaaaag actattgatt ttgacgaggt tatcgaaaag gtaaagaact accgtggcag
     7441 cggtaacttt gcgttcaatc agccgctctt taaaaacgaa gaggagtaca gaaaattctg
     7501 cgaccgtcat gcaaaggctg atgttaagca gaaggagcta aagggttaca caggcaaggc
     7561 ttatatagga atggacgcag gttcgacaac cgtaaagggc gttgtcctca atgatgacgg
     7621 tgagctgctc tattcaaaat atctgccatc aaagggaaac cccgttgaga ttatgaagca
     7681 attccttgac gaggtttacg aaataaatcc cgaaataaat gttgtttctt ctgccgtaac
     7741 aggttacggt gaggacattg taaagaacgc atttgcggtt gattacggca ttgttgaaac
     7801 aatcgcccac tttaccgccg caaaatactt tatgcctgat gttgaattta tcatcgatat
     7861 cggcggacag gatatcaaat gctttaagat acataacggt gcaattgaca atatattcct
     7921 taatgaggct tgttcatcgg gttgcggaag ctttttgcag acctttgcaa acgctctcgg
     7981 atatgagatt gccgactttg caaagctcgg actttttgca aagcgtcccg ttgacctcgg
     8041 ctcacgctgt accgtattca tgaattcaag cgttaagcag gctcagaaag acggcgctac
     8101 aattgaagat atctcggcag gtctttcact cagcgttgta aagaatgccc tttacaaggt
     8161 tattcgtgcg tcaagccccg acgaactcgg caagcgtgtt gtggttcagg gcggtacttt
     8221 cctgaacgac gctgttttgc gtgcatttga acaggaaatg ggcgttgaag ttgtccgccc
     8281 caacattgca ggacttatgg gtgcttacgg tgcggctctt tacgcaaaga aaaagtcaaa
     8341 gggcgttggc aagagtacaa ttaccgacaa aaagggactt gatgaattcg ttcacgaaat
     8401 caaggttgca aactgcggta tgtgcaacaa caactgccgt cttacaataa attcattcgg
     8461 caagggcaga aagtttattg cgggaaaccg ttgtgaaaga ccaatcacaa agaaagctcc
     8521 tgcaaacgat atgaatatgt atgcctataa gctgaatctc attgattcct acaagcctgt
     8581 tgaaggcata agaggtaagc ttggaattcc tatggcgctc aatatgtatg agctttatcc
     8641 gttctggtac agattcttta cagaacttaa atttgaggtg ttccactcac cgtattcaac
     8701 aagaaagctt tatcagagag gtcagcagac gattccgagc gataccgttt gcttccctgc
     8761 aaagcttgtt cacggtcaca ttcagactct tattgatatg ggtgcagaaa caattttcta
     8821 cccctgtctt tcctataatt ttgacgagca tctcggagat aaccattaca actgtcctgt
     8881 tgttgcttac tatcccgagg ttatcaaaaa caatatgaag gatatacgca aggttcactt
     8941 cataaaggaa tactttggta ttcaccgccc gaacgatttt cctaagaaag cctatgaaag
     9001 actttcgttc cacttccccg acctcactct taacgaggta agaaatgcgg ctaagcttgc
     9061 atatcaggaa caggaaaatt acagaaaaaa ggttattgac aagggcaacg agattattgc
     9121 caaggctgaa aaagagggca aaaagatttt tgttcttgcg ggcagaccct atcatattga
     9181 tcccgaaatt aaccacggaa tcgacaggct tatctcaggc tttgatgttg caatcgtcag
     9241 cgaagatgtt atttctccga gagttgaaca tttccggact catgttctca accagtggac
     9301 ataccacgca agactttatg cggcggcaaa atatgttaca acaagaaagg acatggagct
     9361 tgttcagctt gtatccttcg gctgcggtgt tgatgcgatt acaaccgatg aggtaagaga
     9421 aattcttgaa agcaaaaata agatttacac tcagattaag atagatgaaa ttacaaacct
     9481 cggagcagtt aaaatccgaa tccgcagttt gcttgctgcg cttgaaaacg attgatgaaa
     9541 ggaaattctg ttatggcaga gttgaagtat gacaaaaaaa caggtcgttt gctgtttaca
     9601 aagcagatga aaaaggaata cacaatcctt atgcccaata tggcgcctat tcattttaaa
     9661 atacttgaaa aggtgttcaa ctactacggc tataagtctg atttgctcaa cacaacaggt
     9721 ccggagattg ctcagacagg tcttaaatat gttcacaacg acacctgtta tccggctttg
     9781 ctggttatag gtcagttcat caatgctctg caaagcggaa agtatgatgt tcacaaggtt
     9841 gccctgatga ttactcagac aggcggcgga tgtcgtgcgt ccaactacat ttttcttttg
     9901 agaaaggctc tcaaaaaggc aggctttgag ttcgttcccg taatttcgct ttcattcggt
     9961 atggagcaca acagcggttt ttctctcaca cttccgctta tccgcagatt tgtcggcggt
    10021 cttgtgtacg gcgaccagtt aatgctgctt tcaaaccaga caaagcccta tgaggtgaac
    10081 aagggtgaaa gtatggcact tgttgatgag tggacggata agatttccga tatgctcata
    10141 cagggcaagg gctacactct tgaagaaatt gacgaaactc ttgataaaat tacaaagtca
    10201 tttacgaaaa tagagcttaa taaagtgccg aaggttaaag tcggtattgt cggcgaaatc
    10261 tatgtaaaat actccaaaat ggctaacaac ggccttgagg actttcttgc agatcaggat
    10321 tgcgaggttt gtatccccgg acttatgggc tttgcatcgt ttaaggttga taaccgaatt
    10381 gaggactaca agatgttcgg cggcagcaga gtaaagtaca agttctgtat gatgctcctc
    10441 aactacctca caaagctgga gggacttatg gttgatgcgg cagaaaagta cggctttgtt
    10501 ccgcctcaca gatatgctca cacaaaggag cttgtaaacg gtgttattgg ctacggcagt
    10561 aagatgggcg agggttggtt gctgacagcc gagatgattg aacttgccga tacgggctat
    10621 gagaatatcg tatgcacaca accgttcggt tgtctgccga accatatcaa cggtaagggc
    10681 gcaatcagaa agattaaaga aatcagaccg aatgccaata ttgttaccat cgactatgat
    10741 ccgggtgcgc ctaaggtaaa tcaggagaac cgtatcaagc tgatgcttgc tgtcggcaaa
    10801 gaagaactca ggaaaaagct tgaggctgaa aaaaatggcg aaaaagccga atcgtcagag
    10861 aaaaagtaat ttaatatcaa tgcttatgag ccatcgcaga ttgcggtggc ttttttattt
    10921 ttcggtaata tcaggcagaa aaagctaata caattttaca ggggtttatc tcgtttttaa
    10981 ggaaaaaata agtgtaaaaa tcgggggata ttatgaaaaa acgacttaaa ggattttttc
    11041 aaaggcttgc acggtggctg aatgtgcgtg aaatgcgaca gcacaaggtt aaggcaggcg
    11101 tttacatcat aataaggctc atacttgtgt cacttttgac tgccggcatt ttaaacggga
    11161 aatgggagaa tgtcatgacc tgtgtgttaa cgctcggact gttgatgctt ccgttgttca
    11221 ttgaccgaaa gctgtcggtg gcgttgccga gtgtgcttga aacgattgtt gtgctgttcg
    11281 tgtttgcggc aaatgttatg ggcgagctcg gtgcgttcta cgaaaagatt ccgatatggg
    11341 attcattgct ccatgccgtg aacggcttta tctgtgcagg cgtcggtttt gggctgaccg
    11401 atattttgaa cagaagcgaa cgcgtgaaat tgagcctctc gcccatgttc gtgtgcctgt
    11461 tttcgttctg cttttcaatg acagtcggtg ttgtgtggga gttttttgag tttggttcgg
    11521 atatgctttt tgaaaaggat atgcaaaagg acaccgtaat cacggcaata cattcgggct
    11581 tgatttcggg caagccgaat gtgataatgc acatcaggga tataacatca accgttgtga
    11641 acggtgaaaa tctcggcatt aacggctatc ttgacatcgg tctgattgat acaatgaaag
    11701 atttgcttgt taattttgtc ggagcggcag tctttgatac cataggttgg ttttacctga
    11761 aaggaagaag tgcaggattt ttgcggaatt ttatcccaag gaagaagtag cggcgatcag
    11821 tgatcgccaa tcggtttggt tgtaaaacca aaccgaacaa accgcaagcc aattttgtgg
    11881 tattattatc tgttaaagca atcatataat gtcgaaccaa ttttacaatt ggttcgattg
    11941 gcggtcaatg accgccgcta cgggaatgca cattattttc agacaaacaa aagggcagtc
    12001 acattgccgt gactgccctc ttgcttttgg tgatattctt atattaaaat tacttatctt
    12061 cctgaagtgt gatttcaacc tcgccgtcgc ccgatgatga gctgtaatat ttaaccttga
    12121 ttttgtcccc cggcttgtgg gtttcaagaa tcgcataaac atctgcaaag cttgtaattg
    12181 tttcgccgtc aacctctgtg atgatatcgc cttctttaag gtttgtgccg tcacacggac
    12241 cgcccgatac gatactctga acataaatgc cctgcggaat gttgtaattt gatgcctgat
    12301 cggaggttac cgcaatgccc gaaatgccga tttttactct gccttcaaca tagccgttct
    12361 ttacaagtgt gtcaacaatg ttttttactg tctgtgacgg aattgcaaag cccatacctt
    12421 cgtaagtttc ggaaacaatc tttgaagttg taattccgac aacctgaccg tagtagttta
    12481 caagcggacc gcccgagttg cccggattga ttgcggcatc ggtctgaatg tactttgtaa
    12541 ggcttgatgt tgaaagtttt ctgtcaagcg ccgaaataac gcccttggtt gttgtgttct
    12601 gatagtcaag accgccgggg ttgccgacta cgataatatc ctgaccaacc tcaagctgtg
    12661 acgaatcgcc gaatgttgca ggagtaagtc cctttgcatc gtccattttg agaactgcaa
    12721 tatcggttct tgaatcgtaa cctacaacac ctgccttgta taccttgccg tcagatgtta
    12781 caactctgat agcataggct gttttgctgt tgccgattac atgagcgttt gtgataacat
    12841 agccgtcctg tgagaagata attccgcttc cctgtgaaga tgcggttttt gtgtcagcct
    12901 gatcgggtac atcgtccgag taacagagaa tgccgactac cgagtcggaa accttttcgg
    12961 acgcttttgc ggctgtgtag ctgtcgtttg tttttgtgtc tttcggattg ctttcaagtt
    13021 tcatacccga gtaatccttg tttaccttgt cactgtagtc tgactcatcg tgagttttac
    13081 tctgtgaaga tgtgtcggga agggtttcaa acggtgttgt actgtcttct ttcggaactc
    13141 tgaacgaatt gcccgaatca cttcggtcgt tgttcaaatc ttcttttatg tcagccgaaa
    13201 atccgtacac catcatgccg ataaaaccga ttgtaagaag tgaacagaga acgataatca
    13261 acgcaattat tccgcccttt gttttctttt gggggtactg tgcgaacatc tgcggattgt
    13321 attgctgatt gtatgtaccg ttgttgccgt agggaggctg tccgtacata ttctgctgat
    13381 acggaggtac attctgattg tatcctgtgt tgttttgata ctgtccgtac tgctgattgt
    13441 tctgattata ctgcggattc tgtccgctgt agggatactg accgtaaccg tactgccacg
    13501 gctgagcgga ggtgttcgga ttcggatttt ggttctgctg atacggcgga acattttcag
    13561 tcggatttgc atcgtttgcc gtattttgat tgttgttgcc gaaaatgtaa tcgccgtacg
    13621 gtgtgttgcc gttctgcggc tgaacatttt gagcctgttc ttcctgtgtt tcgggttcgg
    13681 acacgggaat tgtctgttcc gtgttcatat tattgttttg tacgggcctt tcggtgaacg
    13741 gcttttgcgg ttcaaaacca cccatattgt tgttgtcaaa attgtccata aaagttactc
    13801 ctacatttat ttgttaccgt ggggtgaata ttatccgccc gccacggtga aattgtttgt
    13861 ttaaattaat ttatattaat gtaataaaaa ttgtgtgtca gtttgtagcg gcgaaccgtg
    13921 ttcgcca
//
