LOCUS       c00073_gnlPro..        16262 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HNDODLHM_73.
ACCESSION   c00073_gnlPro..
VERSION     c00073_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 21:59:04
            Original ID  :: gnl|Prokka|HNDODLHM_73
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16262
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16262
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3269:6262]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3270..6262
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16262
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16262
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(420..1607)
                     /locus_tag="ctg73_1"
                     /transl_table=11
                     /translation="MKKKIFILLLCVVLIATCILCGVTGIFGNDSQNSPKPQTPDTAVT
                     ENTTFPSKVDSLTLKVGESKLIELSSEKAKSVTKWTSSDSKIVTVDDGGRVDALKEGTT
                     LISAISKDKSKSEFQVTVTKSTAKKQQSYSTCITANLDKLESNKRNTAKNLYAIKVNRT
                     ANCVTVYTYDEKGKYTIPVRAMICSTGLDNSTITGDYTIGIKSEWLSLVGNVFGRYISG
                     ISGDYLFHSVPYYSMSEEDLELEEFNKLGEQASQGCVRLAVSDAKWVYDNCPTGTNVSI
                     YDDAENAGPLGKPDAIKITDFTNKWDPTDSNKKCPYAKATPIISGTNDYTIKSGGEFYA
                     LAGVTAVDTCGNDITSNIEVFGNVVTTRKGKYKVTYSVTDVLKRTSNVTITVTVQ"
     CDS             1772..2308
                     /locus_tag="ctg73_2"
                     /transl_table=11
                     /translation="MVIIMAHPIKHFRTITRHRHKVIANCARAGILRQGLIHDLSKYSP
                     TEFIPGAKYFQGTRSPNEKERELYGYSQAWMHHKGRNRHHYEYWNDYNPKTKQIENVEM
                     PVKYVIEMFCDRVAASKIYNGKNYTDGAPFTYFCRIRGKHRMHPNTEALLEKLLVMLRD
                     EGEEKTFAYIRSMKK"
     CDS             2512..3003
                     /locus_tag="ctg73_3"
                     /transl_table=11
                     /translation="MKTDRVITAMIEYFGSDKKRIHHFLKVYSFAKTIGESENLLPDDQ
                     ELLEISAIVHDIGIKVSEEKYNSSAGKYQELEGPHEAEKLLAALGYEKTFIDKVCYLVG
                     HHHTYGNIDTLPYRILVEADFLVNLYEDDSSRSAAEQAYDKIFRTNTGKNLLKIMFLTP
                     "
     CDS             3270..5507
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_4"
                     /sec_met_domain="Gly_radical (E-value: 2.7e-41, bitscore:
                     131.3, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 7.8e-272, bitscore:
                     893.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREEWTNFAGGKWESDIDVRDFIQRNYTPYDGDQSFLEGPTEATD
                     KLWGELKELQKEERAKGGVLDMETEVVSGITAYGAAYLDKDLEKVVGLQTDKPLKRAFM
                     PYGGIKMAEQSCQMYGYTPSPKLHEIFTKYHKTHNQGVFDIYTPEMKLARHNKILTGLP
                     DTYGRGRIVGDYRRVALYGIDRLIEGKKEDFAETNRQGMRRGDFQLREEIADQIRALND
                     MKEMALSYGFDISQPAKNAAEAVQWLYFGYLAAIKTQNGAAMSVGRVSTFLDIYIERDL
                     ENGTLTESQAQELVDHFVMKCRMVKFARIESYNQLFSGDPVWATLEVAGLGIDGRSMVT
                     KNDYRFLHTLENMGPSPEPNLTVLYSSRLPENFKKYAAHISVTTSSIQYENDDVMRPVW
                     GDDYSICCCVSATQTGKEIQFFGARANLAKCLLYAINGGIDEKTKMQVGPEYTPITSEY
                     LDYDEVIKKYDTMMDWLAHLYVGTLNMIHYMHDKYYYEAAEMALIDTDVRRTFATGIAG
                     FSHVVDSLSAIKYAKVKVIRDEDGIAVDFETEGDFPRYGNNDERADKIAVDLLKTFMAK
                     LKYCHTYRDSEPTTSILTITSNVVYGKATGSLPDGRKAGEPLSPGANPSYGAEQNGLLA
                     SLNSVAKLPYEYALDGISNTQTINPGALGHNDDERVDNLVNVMDGYFDQGAHHLNVNVF
                     GTEKLIDAMEHPEKEEYANFTIRVSGYAVKFIDLTREQQLDVIARTCHDRM"
     CDS             5507..6262
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 76.2;
                     E-value: 1e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_5"
                     /sec_met_domain="Radical_SAM (E-value: 1.9e-30, bitscore:
                     97.2, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDNAVKGFVHSIETFGSVDGPGVRFVIFLSGCAMRCQFCHNPDT
                     WKHDENTVEYTADELLNKALAYRPYWKNKGGITVSGGEPLLQIDFLLDLFKKAKKQGVN
                     TCIDTSANPFTTKEPFYSKWKELMEYTDLLLLDIKHIDNEQHKILTGQPNTNILEMARQ
                     LSDMGKPVWIRHVLVPERNDKDEYLFRLADFIRSLRNVERVEVLPYHTLGVYKWKALGY
                     DYPLEGIEPPTKERVKNAEMILNGEKTRE"
     CDS             6614..8467
                     /locus_tag="ctg73_6"
                     /transl_table=11
                     /translation="MKSENIKKFGCVLLSAIMLSGISVCAVSAEEKSTEIHIVHTNDIH
                     GYYKSTSGGQIGFDAVKTIADKENADLILDAGDTFHGQSFATVEEGKSIAALMDAVGYD
                     AMTPGNHDWSYSADRLRELDRESSFTILASNVADTNGNRYFDNNFYIKNVTADDGTKVR
                     VGVFGVIDEDFYTSTSAKNVENVRFENSAETATAYANFLRDDENCDIILALTHNANPEK
                     FIAETSGIDAVIAGHQHILIDKYCTDSDGKSVKLVEANCFFKNVGVLTLTYSNEKGVTD
                     AVEKTYSSADTQGMSDEKIASDISAIEKREQSVLSEVIGESSREYAYSWEELRTSEQEI
                     GRIVTAAYLDFTGADVAMENAGGIRSGIPKGNVTYSDLISISPYGNVLVEKELTGQQII
                     DILEFSVDLMKKNNAVYDLQKQAIKDGEDPYQYSWPDNSGSVMQFSGLSAVYDYSKPYG
                     GRVSDVKIGGKAIDTLKTYRVVSNNYAFDSSDYGDVASLTTVKEYTTCEQILRDYIGKG
                     DFEKAAANANLVEKSSPSEEPTATQEQTVQTAPTGEPATVGTTSVNPTSATGGAATSDS
                     SPSQPGKNGGVQTGVTATAVMMLVVISGGVLFALAERKKRI"
     CDS             8600..8818
                     /locus_tag="ctg73_7"
                     /transl_table=11
                     /translation="MDKNKKLFYTIIGAISALAVATAAFLALKKHRCAEQKLIEEIDDI
                     VSEKEPEEAAKEEPQAEVTADELAEEE"
     CDS             complement(9129..10280)
                     /locus_tag="ctg73_8"
                     /transl_table=11
                     /translation="METLIIGKPKIEKLDNRARLCSKISENGKPSYTLWFDVDAKYADY
                     LTESADAFVVALLPYAMNNSLNILAEAKMSKQLCFQLNEIFIPVLTKNSKLFNKISISA
                     KELTQENYCCKNASATGFSRGVDSFDTICSLSENRTEKLSHLTFFNVGSHRSTANYTPE
                     QSAELYKNRLEIAKKSAKIFDMPLIDINSNLGEHLTLPYVKVHHYCSFSAVLCMQKFFK
                     NYYYASGYPISSFSIKQCDTGSAHYEAFTASMLSTESTDFYITGLEKTRLEKVDFISKF
                     PITYDNLNVCYYGENNCGHCEKCVRTQFELMALGKLELYKNVFDIPKFYRDKNKYMNYV
                     LKHQNKDYYAEILSLMKKKGFKLTPIQKIKKAVYAVYLKFRGH"
     CDS             complement(10296..11480)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) UDPG_MGDP_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) UDPG_MGDP_dh"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg73_9"
                     /sec_met_domain="UDPG_MGDP_dh_N (E-value: 3.5e-37,
                     bitscore: 118.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="UDPG_MGDP_dh (E-value: 4.5e-29, bitscore:
                     91.4, seeds: 679, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIAIAGTGYVGLSNAVLLSQKHEVTAVDVVESKVRLINEKKSPI
                     ADREIEEYLADKKLNLVATVDAKSAYKNADFVIISTPTNYDDERHFFDTSSVEAVIELV
                     IECNPNAVIVIKSTIPVGYTKSVIEKYKYTKILFSPEFLREGKALYDNLYPSRIIVGVD
                     MANEGLKKSAETFATALADCAIKENIDTLFMDYTEAEAVKLFANTYLAMRVSFFNELDT
                     YAEMKNLNTKSIIDGVCLDPRIGNHYNNPSFGYGGYCLPKDTKQLKANFSDVPNDIISA
                     VVTSNKTRKEFITSQIMNKNPKAVGIYRLTMKSNSDNFRQSSIQSVMELLKNNGIELII
                     YEPTLKVDLFEGFSVENDFEKFVTKSDVIVANRYSSVLDCVKEKVYTRDLFFRD"
     CDS             complement(11495..12520)
                     /locus_tag="ctg73_10"
                     /transl_table=11
                     /translation="MSNLKCKGCLMTYPLSECSMQGMFGELCPDLIISFGNNIASYKLK
                     PMIKAHKEKFVHWQIDTAGRIRDFSDKLTDVFECTPQYFFNCFAENAPQDSKNDMTYYN
                     MWNDDIKMLDYSSNLPFSNMYVAKKLAEIIPDRSVLHLAILSSTRTMQFFDLKPNVKVY
                     SNIGALGIDGCMSSFFGQASATDELAFCVVGDLSFFYDMNSAGIRGIKNNARIILLNNG
                     GGSEFHFFMGKEKIPTINQYICAEHHKGAKGWIESLGYDYYSATTKEEVDNIIPTLAEE
                     SDRPIFVEIFTDMEEDAKLINRLFHDNRMKFGGMKLKMMEKAKSILSPSQIQKAKKLLK
                     K"
     CDS             13151..13414
                     /locus_tag="ctg73_11"
                     /transl_table=11
                     /translation="MNYRNITASGRKHQFVDIIFFQKCSEQLNAFYCRIHTLSSALVFD
                     NSGTACNQSGFAVKNIVILLLYIHGNNIFCFKGFDYALSDFF"
     CDS             complement(13434..14513)
                     /locus_tag="ctg73_12"
                     /transl_table=11
                     /translation="MKKVGIVTFHRALNYGAVLQSYALQKTVSSLGAECEIVDYICPKI
                     TADYKPFRIYKNDLLKSFAKSCVMVRRRAKRRDAFKSFFNNYLVKSKKSYTPQNIGELK
                     SDYDLFISGSDQVWSPRCVGFDPAYFLTFADDRQKYSYAASFAVPTLPDEFIDEYKKRL
                     NGFQKFSVREPSGEKLVKELTGRTAETHLDPTLLISADEWKKIAVSKIDKPYILIFTAN
                     PAVSLVDFAIKLSKEKNLPVYCINDAPHPVSHGINYIVAPTVEEFVGCFKNAEYVVTNS
                     FHGTAFSVIFNKNLFVEFKNKSGRNIRSEGLLKSLGIDREIVDGNCRETEINWYDVNEK
                     IKNQTIISLDYLKSFVSGD"
     CDS             complement(14513..15427)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg73_13"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.7e-30,
                     bitscore: 96.8, seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEYTFSVFTPSYNRAKTLPRLYEALKRQTYRNFEWIIVDDGSAD
                     NTKETVEKFISDRPDFNITYKYQTNKGKHIATNVAAQIAKGEFFITIDSDDSVKDNALE
                     TFINEWNKIPDEDRSKYKGISCRTCNESGKTNGCPLPSERFDCSDLDLRLKYKIDGEMW
                     GMTKLEIIRANPYPCVSGLHFYPENIYWDNIGRKYITRFIDTPLRYYINDQENSLTGNA
                     YSAHRETIFVRLHFINECWDYAKSNPKFFIKQFVGLSRDGLLNGKRFSEIKKMPDTFSK
                     RALAVIFYPMGYFLYKKQSGGSR"
ORIGIN
        1 cttgtttgct atcgcaattt tgttattgct gagtatgact cgtcatccgg caagcgtatt
       61 caccgcaaga tttcaagatt gtgaatttgt ataccatgtc cttgcacagg tggttaccat
      121 gttgcacttg acacacggtt cacccataca ttattacagt tgctttgcag catttataaa
      181 atttgtatta atatatagtc tgtaccgttg cttacgagcg aatgatatcc gccccaacag
      241 ataaacaaca actttcatat ataaaaaaca gtcgggaaga cgatgttttg cattttgcaa
      301 accgtcttcc cgacattcat tttacatttt caattttaca ttttcaattt aaaatctccg
      361 ttcgggcatc tttattttcg cttttgcgaa actatcttct taaattgact gcaccgtgtt
      421 tattgcaccg ttaccgtaat cgttacgttt gatgttcttt taagcacatc ggtgactgaa
      481 tatgttacct tgtacttgcc ttttcgggtg gttactacat tgccgaaaac ttcgatattt
      541 gatgttatgt cgttcccgca ggtgtcaacg gctgttactc ctgcaagggc gtaaaattcg
      601 ccgccgcttt tgattgtgta atcgtttgta ccgctgatta ttggtgttgc tttggcatac
      661 gggcattttt tattgctgtc tgtcggatcc catttgttgg tgaaatcggt aattttgatt
      721 gcatccggtt ttccgagagg gcctgcattt tctgcgtcgt catatatgct tacattcgtg
      781 cctgtggggc agttgtcata aacccacttt gcatccgaaa ccgcaagtct tacgcatcct
      841 tgtgacgcct gttcgccaag cttgttgaat tcctcaagct ccaaatcttc ttcgctcatt
      901 gagtagtagg gaacggagtg gaaaagataa tcgccagaaa ttccgctgat gtatcttccg
      961 aaaacattgc ccacaaggga aagccattcg gacttgattc cgattgtgta gtcacccgtg
     1021 attgtcgaat tgtcaagacc tgtggagcaa atcatcgccc ttacggggat tgtgtacttg
     1081 cccttttcgt catatgtgta aaccgtcacg cagtttgccg tgcggttgac tttgattgcg
     1141 tacagatttt ttgccgtatt acgcttgttg ctttcaagct tgtcaagatt tgccgttata
     1201 caggttgagt agctttgctg tttttttgca gttgattttg tcaccgtaac ctgaaattcc
     1261 gactttgatt tgtcttttga aatggcagaa atcagagtcg taccctcttt gagagcgtca
     1321 acccttccgc cgtcatcaac ggtaacaatt ttactgtccg agcttgtcca tttggtaacg
     1381 gattttgctt tttcggatga cagttcaata agctttgatt cgccgacttt taatgtgagc
     1441 gaatcgacct tgctcggaaa tgtcgtattt tcggttactg ccgtatcggg cgtctgcggt
     1501 tttggagaat tttgagaatc atttccgaaa attcccgtca caccgcataa tatgcaggtt
     1561 gcaatgagga caacacaaag taaaagaatg aaaattttct ttttcataga ttacctatcc
     1621 ttatagaatt taacattaaa tggttacaaa attttaacct ttgtatatta taactttttt
     1681 tcgacaatct tgcaagtgct attttaaatc ggcaagaaat gtggtaaaat gtcagtcgga
     1741 gaatgttttg tattttccaa actaacaatt tatggtgata attatggcac atccgattaa
     1801 acatttcaga acaataaccc gtcacaggca caaggtaatt gccaactgtg caagggcagg
     1861 aattctcaga cagggcttaa tacacgattt gtcaaagtat tcacctacag aatttattcc
     1921 gggtgcaaag tattttcagg gcacgagaag tcccaatgaa aaggaaagag agctgtacgg
     1981 ctattcacag gcgtggatgc atcacaaggg cagaaaccgt caccattacg aatactggaa
     2041 cgattacaac ccaaagacaa agcagattga aaatgttgaa atgcctgtaa aatatgttat
     2101 cgaaatgttc tgcgaccgag ttgccgcaag caagatctac aacggcaaaa attacacgga
     2161 cggcgctccg tttacatatt tttgcagaat cagaggcaaa caccgtatgc accccaacac
     2221 cgaggctttg cttgaaaaat tattggttat gctgagagat gagggtgaag aaaagacctt
     2281 tgcatatata agaagtatga aaaagtgatt gtttgtgcga atcctcccgt ttgaaatata
     2341 gtcgcaatgc gttgtacata aatgtactgc tttttgctcg ttatttcaga cagtgctttg
     2401 ctccatttat ccgccacagg cggcggtcgc aaggctaccc ctacagaatt gcacaaacaa
     2461 aaaactatct acacgaatag ggtacggcgg ctcgccgtaa ggagtgataa tatgaaaacc
     2521 gacagggtta taactgctat gattgaatat tttggaagtg acaagaaaag aattcaccat
     2581 tttctcaagg tttattcatt cgcaaagaca atcggtgaaa gtgaaaatct tttgcccgac
     2641 gatcaggagc ttcttgaaat ctccgcaatc gttcacgaca tcggcataaa ggtgagcgaa
     2701 gaaaagtaca attcgtctgc aggaaagtat caggaacttg aaggtcctca cgaggctgaa
     2761 aagttgcttg ccgctctcgg ctacgaaaaa acatttattg acaaagtttg ttaccttgtg
     2821 ggacaccatc acacctatgg aaatattgat actttgccgt accgaatttt ggtagaggct
     2881 gacttccttg tgaaccttta cgaggacgat tcaagccgca gtgcagcaga gcaggcatat
     2941 gacaaaatat tccgcacaaa tacgggaaaa aatctgctga aaataatgtt cctcacaccc
     3001 taaaattgta ctcatttacc atagtgtttt gagtgtgaaa aagtggtgta aaaagtatct
     3061 caaaatgctt gacaacgccc ttaaaaagtg ttattttaat ggtgttggtt atatgattat
     3121 aaaagtgaat aaatgacaga atacaaggat gtatgacgat tttttcaagg agctgacctt
     3181 accgggcgtc tgcttggaat tgagtcggca tttttttgtg tcatatacaa aattcagtat
     3241 taattatcat tatcggaggt tttacagtaa tgagagaaga atggacaaat tttgcaggtg
     3301 gcaaatggga gtccgacatt gatgtcagag acttcattca gagaaactac acaccttatg
     3361 acggcgacca gtctttcctt gaaggtccta cagaagctac agacaagctc tggggcgagc
     3421 tcaaggaact ccagaaggaa gaaagagcca agggcggcgt tcttgatatg gaaactgagg
     3481 ttgtaagcgg catcacagct tacggcgctg catatcttga taaagacctt gaaaaggttg
     3541 taggtcttca gacagacaag cctctcaagc gtgcatttat gccttacggc ggtatcaaaa
     3601 tggctgagca gtcatgccag atgtatggct acactccaag ccctaaactc cacgaaatct
     3661 ttacaaaata tcacaagact cacaaccagg gtgtattcga tatctacact cccgagatga
     3721 agcttgcccg tcacaacaag attcttacag gtcttcccga cacatacggc agaggcagaa
     3781 tcgtcggtga ctacagaaga gttgctcttt acggtattga ccgtcttatc gaaggcaaga
     3841 aagaggactt tgcagaaaca aaccgtcagg gtatgagaag aggcgacttc cagcttcgtg
     3901 aagaaatcgc cgatcagatt cgtgctctta acgatatgaa ggaaatggca ctttcttacg
     3961 gctttgatat ttcacagcct gctaagaacg ctgcagaggc agttcagtgg ctctacttcg
     4021 gctatcttgc tgctatcaag actcagaacg gcgctgcaat gagcgttggt cgtgtatcaa
     4081 cattcctcga catctacatc gagcgtgacc ttgagaacgg tacacttaca gaatcacagg
     4141 ctcaggaact cgttgaccac tttgttatga agtgccgtat ggttaagttt gcaagaattg
     4201 agtcttacaa ccagctcttc tcgggcgacc ctgtatgggc tacactcgaa gttgcaggtc
     4261 ttggcattga cggccgttca atggttacaa agaacgacta ccgtttcctc cacacacttg
     4321 agaatatggg accttcacct gagccaaacc tcacagttct ttattcttca agacttccgg
     4381 agaacttcaa aaagtatgct gctcatattt cagttacaac aagctcaatt cagtacgaga
     4441 acgatgatgt aatgcgtcct gtatggggcg atgattactc aatctgctgc tgcgtatccg
     4501 caacacagac aggtaaggaa atccagttct tcggtgcaag agctaacctt gctaagtgcc
     4561 ttctctacgc tatcaacggc ggtattgatg aaaagacaaa gatgcaggtt ggtcctgaat
     4621 atacacctat cacatcagag taccttgatt atgacgaagt tatcaagaag tatgacacaa
     4681 tgatggattg gcttgctcac ctctatgtag gcacacttaa catgattcac tacatgcatg
     4741 ataagtacta ctatgaggca gcagaaatgg ctcttatcga tacagatgta agaagaacat
     4801 ttgcaacagg tattgcaggc ttctcacatg ttgttgactc actcagcgct attaagtacg
     4861 ctaaagttaa ggttatccgt gacgaggacg gcattgctgt tgactttgaa acagagggcg
     4921 acttcccaag atacggtaac aatgacgaga gagcagataa gattgccgtt gatcttctca
     4981 agacattcat ggctaagctc aagtattgcc acacatacag agattcagag cctacaactt
     5041 ctatccttac aatcacatca aatgttgttt acggtaaggc tacaggttca cttcctgacg
     5101 gcagaaaagc aggcgagccg ctttcaccgg gtgctaaccc aagctacggt gcagagcaga
     5161 acggtcttct tgcttcactt aactctgttg ctaagcttcc ttacgagtac gctcttgacg
     5221 gtatttcaaa tactcagaca atcaacccgg gtgctctcgg acacaacgat gacgagcgtg
     5281 ttgacaacct cgtaaatgtt atggacggct actttgatca gggcgcacac cacctcaatg
     5341 taaatgtatt cggtacagaa aaactcattg acgctatgga gcatcctgag aaggaagagt
     5401 atgctaactt cacaatccgt gtatcgggtt atgctgttaa gttcatcgac cttacaagag
     5461 agcagcagct ggatgttatt gccagaacct gccacgacag aatgtaatgt cggacaacgc
     5521 tgttaaaggc tttgtacact caatagaaac ttttggctct gttgacggtc cgggcgtgag
     5581 atttgtgatt tttctgagcg gttgcgcaat gcgttgccag ttctgccaca atcccgacac
     5641 atggaaacac gatgaaaaca ccgtggaata caccgccgac gagttgctta ataaagcgct
     5701 tgcataccgc ccctattgga aaaataaggg cggtatcaca gtaagcggag gcgagccgct
     5761 tttacagatt gactttttgc ttgatttgtt taagaaggct aaaaagcagg gcgttaatac
     5821 ctgtattgac acgagcgcca acccgtttac aaccaaagag ccgttctatt caaagtggaa
     5881 agagctaatg gaatatacgg atttgctgtt gcttgatata aagcatatcg acaacgaaca
     5941 gcacaaaatc cttacaggac agccaaacac caatattctt gaaatggcaa gacagctttc
     6001 cgatatgggc aagcccgtat ggataagaca tgttcttgtg cctgaaagaa atgataagga
     6061 cgagtatctt ttcagacttg ccgactttat ccgttcgctc aggaatgttg aaagagttga
     6121 agttcttccg tatcacacac tcggtgtgta caagtggaag gctctcggtt atgactatcc
     6181 tctcgagggc attgagcccc cgacaaaaga gcgtgttaag aatgcggaaa tgattcttaa
     6241 cggcgaaaaa acaagagaat aattttgttt ataatataag gaacggcagt atcgcttttg
     6301 atactgccgt ttttgttttg atttttattt gttattctgg tttgtagttt cttcttcagc
     6361 aaaattgatg aatcaaaggt gtattcaaag atttttaagc cgtccttgtt gagaaatctc
     6421 agcgtaactt ttgggttatc aacatcttaa aataatagca gataaagcag aattttgcaa
     6481 taataaaaca gcttgccacc atattcaata taaaactatt gaaaaattgc gcagaatatg
     6541 gtacaattca cccaacaaag cattgatttt acaaacaatt actacatatt cttaatttga
     6601 aaggagtaaa gtaatgaaat cagaaaacat aaaaaaattc ggttgtgttt tgcttagtgc
     6661 cataatgctt tcgggcattt cggtgtgtgc tgtatctgcc gaagaaaaat caacggaaat
     6721 tcatatcgtt cacacaaacg atattcacgg ctactacaag tccacatcgg gcggtcaaat
     6781 cggttttgat gcagtcaaga ccattgcgga caaggaaaat gccgatttga tacttgatgc
     6841 aggcgacacc tttcacggac agtcatttgc caccgttgaa gagggaaaaa gcattgccgc
     6901 gcttatggac gccgtaggtt atgacgcaat gacacccggc aatcacgact ggtcatacag
     6961 tgccgacagg ctgagagagc ttgacagaga aagctctttt accatacttg cctcaaatgt
     7021 ggcagacaca aacggcaaca gatattttga caacaacttt tatataaaaa atgttactgc
     7081 tgatgacggc acaaaggtaa gagtcggagt tttcggcgtt attgacgaag atttttacac
     7141 atcaacatcg gcaaagaatg ttgaaaatgt tcgctttgaa aattcagccg aaacagcgac
     7201 agcgtacgcg aattttctca gagatgacga gaattgtgat attatacttg cgctgactca
     7261 taatgcaaac cccgaaaaat tcattgccga aacatcgggc attgatgcgg taatcgcagg
     7321 tcatcagcac attctcattg acaaatactg tactgacagt gacggcaaga gcgtaaagct
     7381 tgttgaggca aactgctttt tcaaaaatgt aggtgtgctt actctgacat attccaatga
     7441 aaagggcgtt accgatgcag tcgaaaaaac atattcgtct gccgatactc agggaatgtc
     7501 cgatgaaaag attgcgtccg atatttcggc aattgaaaag cgtgaacaga gcgtactcag
     7561 cgaagtaatc ggcgagagca gtagggagta cgcttacagc tgggaagaac tgagaacaag
     7621 tgagcaggag ataggcagaa tcgtaacagc cgcttatctt gactttacgg gtgctgatgt
     7681 tgcaatggag aatgcaggcg gaatccgttc gggtattcca aagggtaatg tgacatattc
     7741 cgatttgatt tcaatttcac cctacggcaa tgtgcttgtt gaaaaggagc ttacaggtca
     7801 gcagattatt gatattcttg aattttcagt tgaccttatg aagaaaaaca atgcggttta
     7861 tgaccttcaa aagcaggcga taaaggacgg ggaagacccg tatcagtaca gctggccgga
     7921 taacagcggt tctgtaatgc agttcagcgg tttaagtgcg gtatatgact attcaaagcc
     7981 gtacggcggc agagtgtcag atgtaaaaat cggaggaaag gcaattgaca ctttaaaaac
     8041 ttacagagtg gtctcaaata actatgcgtt tgacagttcc gattacggcg atgttgcgtc
     8101 gctcacgacc gtgaaagaat ataccacctg cgaacaaatt ctgcgtgatt atatcggcaa
     8161 gggcgatttt gaaaaggctg ccgcaaatgc aaatcttgtt gagaaatcgt caccgtcgga
     8221 agaaccgact gctactcagg aacagactgt tcagactgct ccgacgggtg agcctgcaac
     8281 tgtcggtaca acctctgtaa atccgacttc ggcaacaggc ggtgccgcaa catcggacag
     8341 ctctccttca cagcctggta aaaacggcgg tgttcagaca ggagtgacag caacggctgt
     8401 tatgatgctt gttgtaattt cgggcggagt gctttttgcc cttgcagagc gtaaaaagag
     8461 aatataacac actgacagcc atttgtgcaa agattatcag ttgcctattg aaaaatttgt
     8521 aaaaatgata taaaatagca ataagtagaa aaatacggtt tttccgctga tttatattaa
     8581 tactgaaaga ggtgccggaa tggataaaaa caaaaaatta ttctacacaa tcatcggtgc
     8641 gatctctgca cttgcggttg ccacagcagc atttctcgct ttaaaaaagc acagatgcgc
     8701 agagcagaag cttattgagg aaattgacga tattgtttcc gaaaaagagc ctgaggaggc
     8761 tgcaaaggaa gaaccgcagg cagaagttac agccgatgag cttgctgagg aagaataagc
     8821 aacaagttgt tgcaccaaat tcgtgtagca gtatttgcat atgcgaaagt taaatacccg
     8881 agcggtgctt tcaattaaga atttaaagtt gaaaacagaa aatgatgtcg gcggtgtgcc
     8941 accgcagtct attcaagaaa acagtttaaa aaagaaaatg catcagttgc ccgaaaaggt
     9001 ctgatgcatt tttgttttgt gcgaagtaac cgccaaatcc atagccgtga ggcagtataa
     9061 aaacgcagac atcatctgat atctgctata cctcctcaat ggcttgtcgg ttaaagtaac
     9121 cgtaagcctt aatgccctct gaatttaaga taaacggcat agacagcctt tttaattttt
     9181 tgaattggcg taagcttgaa acccttcttt ttcataagac tgagaatttc tgcataatag
     9241 tccttgttct gatgtttgag aacatagttc atatatttgt tcttgtctct gtaaaatttc
     9301 ggaatatcaa aaacattctt atacagttca agttttccga gtgccataag ctcaaattgt
     9361 gttctgacgc acttttcaca gtgaccgcag ttgttctcac cgtagtaaca cacattgagg
     9421 ttatcatatg taatcggaaa ttttgaaatg aagtcaacct tttcaagcct tgtcttttca
     9481 agacctgtaa tgtaaaaatc ggtactttcg gtactcagca tacttgccgt aaatgcctca
     9541 tagtgtgccg agccggtgtc gcattgtttt atcgaaaaac tgcttatcgg gtatcccgac
     9601 gcataatagt agtttttgaa aaatttctgc atacacaaga cagccgaaaa gctgcaataa
     9661 tgatgaacct ttacatacgg cagggtaaga tgttcaccga gatttgaatt aatgtcaatc
     9721 aacggcatat caaagatttt tgcggatttt tttgcaattt caagacgatt tttgtacagc
     9781 tcggcagatt gttcgggtgt gtaattagcc gtacttctgt gggagccgac attgaaaaag
     9841 gtaagatgac tcagcttttc cgttctgttt tcggaaagac tgcaaattgt gtcaaatgaa
     9901 tccacacctc tcgaaaatcc tgttgccgac gcatttttgc aacagtagtt ttcctgtgta
     9961 agctcttttg cagatatcga aattttgttg aataattttg aattttttgt aagaacggga
    10021 atgaaaattt cattaagctg aaaacacagt tgcttcgaca tctttgcttc tgccaaaata
    10081 ttcagactgt tgttcattgc atacggcaac agcgcaacaa cgaatgcatc ggcactttcg
    10141 gtcagatagt cagcatactt tgcatcaaca tcaaaccaga gagtgtagga aggctttccg
    10201 ttttcgctga tttttgaaca gagtctggca cgattatcaa gtttttcaat tttcggtttg
    10261 ccgataatca atgtttccat acttttaccc tcaaattaat ctctgaaaaa caaatctctt
    10321 gtgtaaacct tttcttttac acagtcaaga acggagctgt atctgtttgc aacgattaca
    10381 tccgattttg tgacgaactt ttcaaagtcg ttttcaacgc taaagccctc gaataaatcg
    10441 actttaagtg tcggttcgta gataattaac tcgatgccgt tatttttcaa aagctccata
    10501 acgctctgaa ttgagctttg tctgaagtta tcggaatttg acttcattgt aaggcggtaa
    10561 attccgacag cttttggatt tttattcatt atctgtgatg taataaattc ttttcttgtc
    10621 ttgttagatg ttacaacagc gctgattatg tcgttcggaa catccgaaaa attggccttg
    10681 agctgttttg tatcctttgg cagacagtaa ccgccgtagc caaaggacgg attgttgtag
    10741 tgatttccga ttctcggatc aagacacaca ccgtcaataa tacttttagt gttaaggttc
    10801 ttcatttcgg catatgtgtc tagctcgttg aaaaagctga cacgcattgc aaggtatgta
    10861 tttgcaaaaa gcttgaccgc ctctgcctct gtgtagtcca taaagagagt gtctatgttt
    10921 tccttaattg cacagtctgc aagtgccgtt gcaaaagtct cggcagattt tttcagtcct
    10981 tcatttgcca tatcaacacc gacaatgatt cttgacgggt agaggttatc atagagagcc
    11041 ttgccctcac gcaaaaattc gggactgaaa agaatttttg tgtatttgta tttttcaata
    11101 acactttttg tgtatccaac cggtatagtg gatttgataa ctataaccgc atttgggttg
    11161 cattcaatta caagctcaat tacagcctca acggacgatg tatcaaaaaa gtgtctttcg
    11221 tcatcgtaat tggtaggagt agagataatt acaaaatcag catttttgta cgcagatttt
    11281 gcatcaacgg ttgcaaccaa atttaatttt ttgtcagcaa gatattcttc gatttccctg
    11341 tcggcaatcg gagatttctt ttcattgatt aaccttacct tgctttcaac aacatcaaca
    11401 gcggttacct cgtgtttctg cgaaagaagt acagcgtttg aaagacctac ataccctgtc
    11461 ccggcaattg ctattttcat ttggtttcac ctgattactt ttttaataat ttttttgcct
    11521 tttgaatctg tgacggactg agaattgact ttgctttttc catcattttg agcttcattc
    11581 cgccaaattt cattctgttg tcatgaaaaa gcctgttaat aagctttgcg tcctcttcca
    11641 tatcggtgaa aatctcaaca aaaatcggtc ggtcggattc ttctgcaagt gtaggaataa
    11701 tgttgtcaac ttcttccttg gttgttgcgc tgtaatagtc gtatccgagt gattcaatcc
    11761 agccctttgc gcccttgtga tgttcggcac agatgtactg attgattgta ggaatctttt
    11821 ccttgcccat aaagaagtga aattctgaac cgccgccgtt gttgagaaga ataattctcg
    11881 cattgttctt gattcctctg atgcctgcgg agttcatatc atagaagaaa ctgaggtcgc
    11941 ccacaacgca aaaggcaagc tcgtctgttg ccgatgcctg tccgaagaac gaagacatac
    12001 agccgtcaat acccagagcg ccgatattgc tgtaaacctt aacattcggt ttcaaatcga
    12061 agaactgcat agttcttgta ctgctgagaa ttgcaaggtg cagaacagaa cggtcgggaa
    12121 taatttcagc aagctttttg gcaacataca tatttgagaa cggaagattg cttgaataat
    12181 caagcatttt gatatcgtca ttccacatgt tgtagtatgt catatcattt tttgaatcct
    12241 gcggtgcatt ctctgcaaag cagttaaaga aatactgcgg tgtacattca aatacatctg
    12301 tcagcttgtc ggaaaaatct ctgattcttc ccgcagtatc aatttgccag tgaacaaatt
    12361 tttccttgtg agccttaatc ataggcttga gtttatatga agcaatattg ttgccgaacg
    12421 aaataataag atcggggcat aactcgccga acattccctg cattgagcat tctgacaaag
    12481 gataggtcat aaggcagccc ttgcacttga ggtttgacat atgctcaacc gatataaggc
    12541 aattgtattt ctcaaagaac ttctcgacgc acgctctgtc atcttccgag aaacagttgt
    12601 tctgaccggc aatgacaaga attttcttat attttgaaag cctttctgca tattcacgcc
    12661 acttctcgga gagcatatcg ggagaaattc tgttgatttt cctaacctga ggaagatttt
    12721 cgcaatcata tacagccgag ttttcaacaa tcggaatatt gatatgcaca ggtcctgttc
    12781 cgtgatggtc aagctccgaa agagcctcgt taataagtct ttcgcagtac catttgtcat
    12841 ttccgccacg cacaacggga agattaacgg atttttttgt aaccgattca aaaatattga
    12901 cctgctgggt tttctgcagc ataagctgat ttaatctgta cgggtctttg tcagcggtaa
    12961 ttgcgacaat cggaacatcc tgataaaatg cttctgtcat acccggaaga tagttgctta
    13021 cagccgtacc cgaggtacag atacaggcaa cgggggattt tgtctgttgt gcaagtccga
    13081 tgccgtaata cacggcactt ctctcgtcaa cgaccgaatg acactcaaaa aaatcgtcat
    13141 tttcaagtga atgaattata ggaatatcac tgcctccggg agaaagcacc aatttgttga
    13201 tattatattt tttcagaagt gcagtgagca actgaatgct ttttattgta gaatacatac
    13261 gctttcctcc gctttagttt ttgataattc cggaaccgcc tgtaatcaga gcggttttgc
    13321 cgtcaagaat attgttattc tccttttgta catacacggg aacaacattt tttgctttaa
    13381 aggttttgat tatgccctgt ctgacttttt ttagtgtatt tttaagactc aatttaatca
    13441 ccgctgacaa aggatttaag ataatccaaa gatattattg tctggttctt gattttttcg
    13501 ttcacatcgt accagtttat ttcggtttct cggcagtttc cgtcaacaat ttcacggtcg
    13561 attccaagac ttttcaaaag accttcggag cggatgtttc ttccgctttt gttcttgaat
    13621 tcaacaaaaa gattcttgtt gaaaataaca gaaaacgctg ttccgtgaaa cgagtttgta
    13681 acaacatatt cggcattttt gaaacagccg acaaattcct caacagtagg tgcaacaata
    13741 taatttatac cgtgacttac agggtgaggt gcatcgttta tgcagtaaac gggaaggttc
    13801 ttttcttttg acagtttaat ggcaaaatcc acaagtgaaa ctgccggatt agccgtaaaa
    13861 atgaggatat acggtttgtc gatttttgaa acggcaatct ttttccattc gtctgctgaa
    13921 atcagcaggg taggatcaag atgagtttcg gctgttctgc ccgtgagttc ttttacaagc
    13981 ttttcaccgc tcggttcacg aactgagaac ttctgaaaac cgttcagcct ttttttatat
    14041 tcatcaataa attcatcggg caatgtcgga acggcaaagc ttgccgcata tgaatacttc
    14101 tgtctgtcat cggcaaatgt cagaaaataa gcgggatcaa aaccgacgca tctcggactc
    14161 cacacctgat cgcttcccga aatgaacaag tcataatcgc ttttgagctc cccgatattc
    14221 tgcggagtat acgacttttt actctttaca agatagttat tgaaaaacga cttaaaagcg
    14281 tctctgcgtt ttgctcttct tcttaccatg acacagcttt ttgcaaagga tttcagaagg
    14341 tcgtttttat aaatgcgaaa gggtttgtag tcggctgtga ttttcggaca gatatagtca
    14401 acaatttcac actctgcacc gagcgaggaa acggtttttt gcaacgcata gctctgaagc
    14461 acagcgccgt agttcaatgc acggtgaaat gttacaatgc ctaccttttt cattatctgc
    14521 ttccccctga ttgttttttg tacaaaaaat atcccatggg ataaaatatg accgcaagag
    14581 ccctctttga aaatgtgtcg ggcatctttt ttatttcgga aaatcttttg ccgttgagta
    14641 agccgtcacg ggaaagtccc acaaattgtt tgataaagaa cttaggattg ctctttgcgt
    14701 aatcccaaca ttcgtttata aagtggagtc ttacgaaaat agtttccctg tgagccgagt
    14761 aagcgttacc tgtcaaagaa ttttcctgat cgtttatgta atatcgcaac ggtgtgtcaa
    14821 taaaacgggt tatatacttt cttccgatat tgtcccaata gatattttca ggataaaaat
    14881 gaagtcccga aacacacgga tatgggttgg ctctgattat ttcaagtttt gtcattcccc
    14941 acatctcacc gtcaatttta tacttcaatc tcaggtcaag gtcggaacag tcaaatcgtt
    15001 ctgacggcag aggacaaccg tttgttttgc cgctttcgtt acaggtgcgg catgaaattc
    15061 ccttgtattt tgatctgtct tcatcgggaa ttttgttcca ttcgtttata aatgtttcaa
    15121 gggcgttgtc ttttacgctg tcatcggagt caatcgttat aaagaattca ccctttgcaa
    15181 tctgtgccgc aacatttgtt gcaatgtgtt ttcctttgtt ggtctgatat ttataggtta
    15241 tgttaaagtc gggtctgtcg ctgatgaatt tctcaaccgt ttcttttgtg ttgtcggctg
    15301 aaccgtcatc aacaattatc cattcaaaat ttctgtatgt ctgtcttttc agtgcctcat
    15361 ataatctggg cagagttttt gctctgttat atgacggtgt aaaaacggaa aaagtatatt
    15421 cattcattgc aacctcaaaa tgataataat ttagcttttt ttaaacttct tcttaatttt
    15481 atccttgata agaacgagtt cttttcttga gaaaatgagc ggaacggaaa cggcatatcc
    15541 tgccagtccg cttgctgcac agagaagaag gaatgacatc cagctgtttg cgtgtacaaa
    15601 gctgttgata aagatgaaca tggtgataac aacagcaaag cagaaccatc ctctgaaaat
    15661 agacctgtaa tatgttgtaa gctttatttt caaaatatgt gcggcgtata acggaacaaa
    15721 tactatcgct ttaagaccga taaaaacaga gctgacgcct gcaatagcat aaacgccgag
    15781 cggtgtaaag tgtatgagca gtaaaacgat aataaccgta agaacaccgc acacaagcga
    15841 gataagaacg gaggccttga gcttgttgca tacggtgaaa aggctagaaa gagttcttgt
    15901 gtgacaggta aataggtatg aaatacatac aagcaccgac aaaatctgaa ttatggtaat
    15961 ttcgtccgga gatttggtcg gctgccacaa tgtatagaac ttgttgccaa acgcaataaa
    16021 tcccgcaaga ggtgcagtca tgagaaaact cataatcttt gacgaaaact ttgtttcttc
    16081 aacaagtaag tccgtgttgt cctttgcata aaggattgta aatctgggag tgaagatatt
    16141 tgcaatggtt gtaataaggt tatcaatgca gtgcggaacg gtgtttgcaa tcgacaaaag
    16201 tcccatgagt cccgctccga gagacaggtt acagattaac aggtcaaggc ctctgttcag
    16261 ag
//
