LOCUS       gnlProkkaJJEOIDNF_160   7890 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JJEOIDNF_160.
ACCESSION   gnlProkkaJJEOIDNF_160
VERSION     gnlProkkaJJEOIDNF_160
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 02:59:08
            Original ID  :: gnl|Prokka|JJEOIDNF_160
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7890
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7890
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3119:4727]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3120..4727
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..7890
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7890
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             3..1631
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 109.1; E-value:
                     4.2e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg160_1"
                     /transl_table=11
                     /translation="MELWIYLTSEGKKDMSSFKEEISKRRTFAIISHPDAGKTTLTEKL
                     LLYGGAINLAGSVKGKRTAKHAVSDWMEIEKQRGISVTSSVLQFKYNGYCINILDTPGH
                     EDFSEDTYRTLMAADSAVMVIDGSKGVEKQTIKLFKVCVMRNIPIITFINKMDRDAKNS
                     FDLLEDIENVLGIHTYPVNWPIGSGKEFKGVYDRNSKKILAFTANNGQKEVEKKELTLD
                     DPALEDTIGYYHKQDLFDEIELLDGAGDEFDLEAVRNGQLTPVFFGSALTNFGVEPFLE
                     QFLQLTTPPLPRETVDEKVEPMSDFFSAFVFKIQANMNKAHRDRVAFMRICSGKFEKNM
                     EVFHVQGNKKMRLSQPQQIMAQEREIVDEAYAGDIIGVFDPGIFSIGDTICSPGHKVQF
                     RGIPTFAPEHFALVRQKDTMKRKQFIKGTSQIAQEGAIQIFQELDAGMEEVIVGVVGVL
                     QFDVLKYRLQNEYNCDIIMETLPYEFIRWIVNDDIDPKTLDLASDTKKIQDLKGNHLLL
                     FTSYWSINWALEHNKGLELAEFGTN"
     CDS             1655..3058
                     /NRPS_PKS="Domain: Aminotran_5 (54-216). E-value: 3.9e-13.
                     Score: 40.9. Matches aSDomain:
                     nrpspksdomains_ctg160_2_Aminotran_5.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg160_2"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.4e-13, bitscore:
                     36.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.1e-10,
                     bitscore: 27.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 9e-14, bitscore:
                     40.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLYDKLKNYSKSGIYPFHMPGHKRTDITEEGIIPYNIDITEIHDF
                     DNLHSPNGVIDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMARNCHK
                     SVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSPTYEGV
                     VSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADATVLSLHKTLPSLTQ
                     TALLITNDSELSEILAENLAVFETSSPSYILMSSIEKCLDFCENSKDKFKEYCCNLKTV
                     REKLKNLKYLKIYDKSDTDFDYDIGKIVISTANANISGTKLAEILRNNYQIETEMAYSD
                     YVIAMTSVCDTEKAFDMLSDALISIDSELSKGADTERVPLKNLYTGKNFNACELYKFNK
                     ETIPFQNSEFRTSAEYIWAYPPGIPLIVPGEIISKELINYIEYLSACKVEIMSTKGGMT
                     DNISVVKKD"
     aSDomain        1817..2302
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg160_2_Aminotran_5.1"
                     /evalue="3.90E-13"
                     /label="ctg160_2_Aminotran_5.1"
                     /locus_tag="ctg160_2"
                     /protein_end="216"
                     /protein_start="54"
                     /score="40.9"
                     /tool="antismash"
                     /translation="IDEIQKKAAKLYNAKNAFILINGSTGGILSAIRSMTNQGDKILMA
                     RNCHKSVYNSAELFNLNVDYIFPDTDSRYNILTSVSPCDIEDKLTKHNDEIRLVIITSP
                     TYEGVVSDIKSISEICHKHGAKLLVDEAHGAHFPFSDSFPDEALNCGADATVLSLHKT"
     CDS             3120..3272
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_3"
                     /sec_met_domain="TIGR03973 (E-value: 9.5e-28, bitscore:
                     84.9, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 4.6e-27, bitscore: 82.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIKTIETRDLKKSVKTGGCGECQTSCQSACKTSCGVANQQCEK
                     CMSEK"
     CDS             3354..4727
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg160_4"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 7.1e-32,
                     bitscore: 98.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.5e-15, bitscore: 46.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.6e-15, bitscore: 46.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.6e-21, bitscore:
                     63.8, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYKLNGYNIVLDVYSGSVHAVDDLAYDVIAMYKNATKEQIID
                     EMLSKYADNPEITKEEISDCIDDVKELEEQGKLFTDDKYENLAFDFKKRNTVIKALCLH
                     IAHTCNLNCEYCFASQGKYHGERALMSFEVGKRAIDFLIENSGSRVNLEVDFFGGEPLM
                     NFDVVKQIVAYARSIEKEHNKNFRFTLTTNGMLVDDDVIEFANKECHNVVLSLDGRKEV
                     HDHLRKTVNGKGSYDIIVPKFQEFVKKRGNKGYYVRGTYTHNNTDFTNDIFHMADLGFT
                     ELSMEPVVCAPDDPYALTYDDLPILFEQYEILAKEMLKREKEGRPLTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDEKYKLGDIFNGVSNTKIQDEFKLCNA
                     YARPDCKDCWARLYCSGGCAANAYHATGSITGIYEYGCELFRKRMECAIMMKVAEAEE"
     CDS             4793..5602
                     /locus_tag="ctg160_5"
                     /transl_table=11
                     /translation="MNEKIIMLGTGSAMVTDCYNTCFLLKSENDCLLVDAGGGNGILSA
                     IKKSGVAWNSIKTMFITHSHTDHILGAVWVIRQISALMNSGKYDGNFNIYCHDECVDSI
                     TAICNHTLAPKFLKNINTKIFINEVKDGEKQNAGSIRLTFFDIFSDKTKQFGFKAVFPS
                     GKVLACLGDEPFNEKCRNFVQNCDYLMCEAFCLYSQKDIFKPYEKFHSTALDAGKLAES
                     LFAKNLILYHTEDETLQTRKSTYASEARTVFNGNIFVPDDFEVIDLK"
     CDS             complement(5594..7507)
                     /locus_tag="ctg160_6"
                     /transl_table=11
                     /translation="MFSTDKSSFNKKDVSDCDYKISLAGNPNVGKSTIFNELTGLRQHT
                     GNWTGKTVEFARGCSKIKDARFCITDLPGCYSLLSFSGEEAVTRECLVQNQNDCVVIVV
                     DCGVIERNLSFALQVLSVTKNAVLCLNLCDEAEKNGIKIDCDELSLNLGIPVVKTCATD
                     KKGLDELKKAIYNVCSGKTKCFRVERNFEGVDILSEKNYKQNIEKLSQIGNKISSDCVK
                     YEKSELNACTRKLDKILTSKTTGIPIMLAMLGILFWITVVGANYPSEWLSNLFGFIKEK
                     LYILFDFLHAPDVVTGLLIDGVYTTLSWVVSVMLPPMAIFFPLFSLVEDSGYLPRIAFN
                     LDRYFSKCGAHGKQSLAMAMGLGCNACGVTGCRIIESPKERLIAILTNNFMPCNGRFPT
                     IIALLLMFFAGTAFTLSSSLEVAALLIGIIVFCVFITLVISKVLSVTILKGEQSGFVLE
                     LPPYRKPQILKTIVRSLLDRTLFVLGRAVAVAAPAGAIIWILANVHISDVSLLKYCTDF
                     LDPFGRFIGVDGVIIMAFILGFPANETVIPIIIMSYMASGTLVDYSSYDQLFQLLSMNG
                     WTITTAVCTIILCILHYPCSTTCLTIKKETGSLKWTLVSMALPTAMGIVLCMITAGVMR
                     LF"
     CDS             complement(7523..7777)
                     /locus_tag="ctg160_7"
                     /transl_table=11
                     /translation="MKSVNQMKEKCSLDKLPLGVTGIVYRVNCNENIKNRIFDFGIMEN
                     SSVIPLFTSPFGDPSAYLVKNAVVALRNNDCKDIIVTPE"
ORIGIN
        1 atatagaatt gtggatatac ttaacctccg aagggaagaa agatatgagt tcatttaaag
       61 aagaaatcag caagcgcaga acctttgcga ttatttcgca tcctgatgcg ggtaaaacaa
      121 cacttacgga aaagctcttg ctctacggcg gagcaattaa ccttgcaggt tcggtaaaag
      181 gcaaaagaac cgcaaagcat gctgtgtccg actggatgga aattgaaaaa cagcgtggta
      241 tttctgttac atcatcggtt ttgcagttta aatataacgg ttattgcata aatattcttg
      301 acacaccggg acatgaggac ttctctgaag atacctaccg tacacttatg gcggcagact
      361 ctgccgtaat ggtaattgac ggttcaaagg gtgttgagaa acagactatc aaacttttta
      421 aggtctgtgt aatgcgtaat attcctatca ttacattcat caacaagatg gacagagatg
      481 caaaaaattc ttttgacctt cttgaagaca ttgaaaatgt tctcggaatt cacacctatc
      541 ccgtaaactg gccaatcggt tcaggtaagg aattcaaggg ggtgtatgac agaaattcta
      601 agaaaatcct tgctttcacc gctaataacg gtcagaaaga agttgaaaag aaagaactta
      661 cgcttgacga ccctgccctt gaagatacaa taggctacta tcataagcag gatttgtttg
      721 atgaaataga acttcttgac ggtgcaggcg atgaatttga ccttgaagca gtccgcaacg
      781 gtcagcttac tcctgtattc ttcggttcgg ctcttactaa ctttggtgtt gaaccattcc
      841 ttgaacagtt cttacagctc acaactccac ctctgccaag agaaacagtt gatgaaaagg
      901 ttgagcctat gtcagacttt ttctctgcat ttgtcttcaa aattcaggca aatatgaata
      961 aggctcaccg tgacagagtt gcatttatgc gcatctgcag cggcaagttt gaaaagaata
     1021 tggaagtgtt ccatgttcaa ggcaacaaaa aaatgcgtct ttcacagcca cagcagatta
     1081 tggctcaaga aagagaaatt gttgacgagg catatgcggg cgacatcatc ggtgtgtttg
     1141 atccgggcat tttctcaatc ggtgacacaa tctgttcacc gggacacaag gtacagttca
     1201 ggggaattcc tacatttgct cccgaacact ttgcacttgt ccgtcagaaa gacacaatga
     1261 agcgcaaaca gttcatcaag ggtacaagtc agattgcaca agaaggtgca attcagattt
     1321 tccaggagct tgacgcaggt atggaggaag ttatcgttgg cgttgtaggc gtacttcagt
     1381 ttgatgttct taaatacaga cttcaaaacg agtacaactg tgatatcatt atggaaacac
     1441 tcccatatga atttatccgt tggattgtaa acgatgacat tgatccgaaa actctcgacc
     1501 ttgcgtccga tactaagaaa attcaggatc ttaaaggcaa tcatcttttg ctctttacaa
     1561 gctactggag cataaactgg gcgcttgaac acaacaaggg acttgaactc gctgagttcg
     1621 gtacaaacta aatatttaaa atatcggagg atatatgctg tacgacaagc ttaaaaatta
     1681 ttcaaaaagc ggcatatatc cttttcatat gcccggacac aaaagaacgg acattacaga
     1741 agagggtata ataccgtata atatcgacat aaccgaaatt catgattttg acaatcttca
     1801 ttcaccaaac ggagttattg atgaaattca gaaaaaggct gccaaacttt acaatgcaaa
     1861 aaatgctttc attctgatta acggttcaac aggcggaata ctttctgcaa tccgatccat
     1921 gacaaatcaa ggcgacaaga tcttaatggc tcgtaactgc cacaaatctg tatataattc
     1981 agcagaactg tttaatctca atgttgatta catttttccc gatacagaca gcagatacaa
     2041 tattcttaca tcggtttcac cttgcgatat agaagataaa cttacaaaac acaatgatga
     2101 aatcagactt gtaatcataa cttcgcctac atatgaagga gttgtttcgg atataaagtc
     2161 aatctccgaa atctgtcaca aacacggagc aaaattactt gttgacgaag ctcacggagc
     2221 gcattttccg ttttcagaca gttttccaga tgaagcactt aactgcggtg cagacgcaac
     2281 agtattgagt ctgcacaaaa ctttgccgtc attaactcaa actgcattgc tcataacaaa
     2341 tgacagcgag ctttctgaaa ttcttgccga aaatttggct gtatttgaaa caagcagtcc
     2401 gtcatatatt ttaatgagtt caatcgaaaa atgtcttgat ttctgcgaaa acagcaaaga
     2461 taaattcaag gaatattgtt gcaatcttaa aacggtcaga gaaaaactta aaaatctaaa
     2521 atatctgaaa atttatgata aaagcgatac tgattttgat tatgatatcg gcaaaattgt
     2581 aatttcaaca gcgaacgcaa atatttcggg aacaaagctt gccgaaatac tgcgaaataa
     2641 ttatcagatt gaaaccgaaa tggcatattc ggactatgta attgccatga catctgtttg
     2701 tgacactgaa aaagcttttg atatgctttc agacgctctg atttcaattg acagcgaact
     2761 ttcaaaagga gccgacaccg agcgtgttcc gttaaaaaat ctctacacag gcaaaaattt
     2821 caatgcctgc gagttgtaca aattcaacaa agaaactatt ccgtttcaaa attcggaatt
     2881 cagaacttct gccgagtata tctgggcata tccacccgga atccccctca tcgtacccgg
     2941 tgaaattata agcaaggaac ttataaatta cattgaatat ctttcagcct gcaaggttga
     3001 gattatgtca acaaaaggcg gtatgacgga caacataagc gtagttaaaa aagattgaca
     3061 aatcaatggc tgtgtgataa tattaaacta acaaaatcta acaaggagtt tgatttatta
     3121 tgaagagaat taaaactatc gaaactcgtg acctcaagaa gagcgttaag acaggcggtt
     3181 gcggcgagtg ccagacttca tgtcagtcag cgtgtaagac atcttgcggc gttgctaacc
     3241 agcagtgcga aaagtgcatg agcgagaaat aattctattt taatttgatt attaaggatt
     3301 atcgccgttt tcccaaaggg ttaacggctt tccttttgtc taacggagat attatgattc
     3361 atcagtataa acttaacgga tacaatatag ttcttgatgt ttacagcggc agtgtacacg
     3421 cagtcgatga ccttgcttat gatgttattg caatgtacaa aaacgcaaca aaagaacaga
     3481 taatcgacga aatgctttca aaatatgcag acaatcctga gattacaaaa gaagaaatct
     3541 ccgactgcat tgatgatgta aaagagcttg aggaacaggg aaagctcttt acagacgaca
     3601 agtacgaaaa ccttgcattt gactttaaaa agagaaacac agtaatcaaa gcactttgtc
     3661 tgcacattgc tcacacctgt aaccttaact gcgaatactg ctttgcaagt cagggcaaat
     3721 accacggcga gagagcgctg atgagctttg aagtgggcaa gagagcaatt gactttctaa
     3781 ttgaaaattc aggcagcaga gtaaaccttg aggttgactt ctttggcgga gaacctctta
     3841 tgaactttga cgttgtaaag cagattgttg cctatgcaag aagcattgaa aaggaacaca
     3901 acaaaaactt ccgttttaca cttacaacaa acggtatgct tgttgatgac gatgtaattg
     3961 aatttgcaaa caaagaatgt cataatgtag ttctcagcct tgacggcaga aaagaagtgc
     4021 atgaccatct tcgcaaaact gtaaacggaa agggcagtta tgacattatc gttccgaaat
     4081 ttcaggaatt tgtcaaaaaa agaggcaaca agggttacta tgtaagaggt acctacacac
     4141 ataataacac agacttcaca aacgatattt tccatatggc ggatttggga tttacagagc
     4201 tttcaatgga gccggttgta tgtgctcccg atgacccata tgcacttaca tatgacgatt
     4261 tgcctatcct ttttgaacag tacgaaattc ttgcaaagga aatgctcaag cgtgaaaaag
     4321 agggcagacc gctcaccttc tatcattata tgattgacct tacaggcggt ccgtgcattt
     4381 ataagagaat ctcgggttgc ggttcgggca cagaatatat ggctgtaaca ccttggggcg
     4441 acctctatcc atgtcatcag tttgtaggcg atgaaaagta caagctcggc gatatcttta
     4501 acggtgtttc aaacacgaaa attcaggacg aatttaaact ttgtaacgca tacgcacgtc
     4561 ctgactgcaa agactgttgg gcaagacttt attgcagcgg cggttgtgct gcaaacgctt
     4621 atcatgcaac aggctcaatc acaggtattt acgaatacgg ctgtgagctt ttcagaaaaa
     4681 gaatggaatg tgccattatg atgaaggttg cagaagcgga agaataaaat tacaataaaa
     4741 ttttcaggca gatacatttt tcttgtatct gcctgtattt tcgaggtgct gtatgaacga
     4801 aaaaattatt atgctcggca caggaagtgc gatggttacc gactgttata atacctgttt
     4861 tcttctgaaa tccgaaaacg actgtctcct tgttgacgca ggcggcggaa acggaatttt
     4921 atccgcaatt aagaaatccg gagtagcttg gaacagcata aagacaatgt ttattactca
     4981 ttctcacacc gaccatatat taggtgccgt gtgggtaata aggcaaataa gcgctcttat
     5041 gaattcaggc aaatatgacg gtaattttaa tatttactgc cacgatgaat gtgttgattc
     5101 aatcacggca atttgcaacc acacacttgc accgaaattt ctcaaaaata tcaatacaaa
     5161 aattttcatc aatgaagtaa aagacggcga aaaacaaaat gccggcagta tccgactcac
     5221 tttctttgat atattttcag acaaaacaaa gcaattcgga ttcaaggctg tttttccgtc
     5281 aggaaaagtt ctcgcctgtc tcggtgatga accgttcaat gaaaaatgca gaaattttgt
     5341 tcaaaactgt gattatctta tgtgtgaagc tttttgtctt tacagtcaaa aagatatttt
     5401 taagccttac gaaaaattcc acagcacagc acttgatgcc ggaaaacttg cagagagtct
     5461 ttttgcaaaa aatcttatcc tgtatcacac cgaggacgaa acacttcaaa cacgcaaaag
     5521 tacatatgct tcagaggcaa gaacagtttt taacggaaat atatttgttc ccgatgattt
     5581 tgaagttatt gacttaaaat aatctcataa cacctgctgt aatcatacaa agcacaattc
     5641 ccattgcagt aggcaaagcc atagaaacaa gcgtccattt aaggctgcct gtttcttttt
     5701 ttattgtcag acaggttgtt gaacacggat aatgaagaat gcaaagaata atcgtacata
     5761 cagccgttgt aattgtccag ccgttcatac tgagaagttg aaacagctga tcgtagcttg
     5821 aataatcaac aagagtaccg cttgccatat atgacataat tataatcgga ataacggttt
     5881 cattcgcagg aaatccaagt ataaatgcca ttattataac gccgtcaacc ccgataaatc
     5941 tgccgaacgg atccaaaaaa tcagtacaat attttaaaag tgaaacatcg cttatatgca
     6001 catttgcaag aatccagatt atcgcacctg ccggagcggc aaccgcaaca gcccttccta
     6061 aaacaaataa agttctgtcc aacagcgaac ggacaatagt ttttaaaatc tgcggctttc
     6121 tgtacggcgg aagttcaagc acaaatccgg actgttcgcc tttcaatatt gtgactgaaa
     6181 gtaccttaga tataacaagt gttataaaaa cacagaaaac tattattcca atcaacaatg
     6241 ccgctacctc aagcgagctg ctcagcgtaa atgccgtacc tgcaaagaac atgagcagta
     6301 atgcaattat tgtgggaaac cgtccgttac acggcataaa attatttgta agaattgcaa
     6361 tcaaccgttc ctttggcgac tcgatgattc tgcaacccgt aactccgcag gcattacagc
     6421 caagacccat tgccatagca agactttgct ttccgtgagc accgcacttt gaaaaatacc
     6481 tatcaagatt aaatgcaatt ctcggcaggt atcccgaatc ctcaacaagc gaaaacaacg
     6541 gaaagaatat agccataggc ggcagcatta cagataccac ccaagacaaa gttgtataaa
     6601 ctccgtcaat caaaagtccc gttacaacat cgggagcgtg taagaaatca aaaaggatat
     6661 acagcttctc ttttataaag ccaaacaaat tgcttaacca ttcgctcgga taatttgcac
     6721 cgacaactgt tatccagaac aatataccaa gcattgcaag cataatcggt attcccgtgg
     6781 ttttgcttgt aagtatttta tcaagctttc ttgtacaagc attcaactct gatttttcat
     6841 attttacgca gtcacttgaa attttgttgc caatctgcga aagcttttca atattctgtt
     6901 tgtagttttt ttcggatagt atatcaacac cttcaaaatt tctttctacc ctaaaacatt
     6961 ttgtctttcc gctgcataca ttatagatcg ctttttttaa ctcatccaaa ccttttttgt
     7021 ctgttgcaca ggtttttaca acaggtattc caagatttag cgataactcg tcgcagtcga
     7081 tttttatacc gtttttttca gcctcatcac aaagattaag acaaagaaca gcattctttg
     7141 tgacagataa cacctgcaat gcaaatgaaa gatttctttc aataactccg cagtcaacaa
     7201 ctattacaac gcagtcattt tgattttgta caagacactc ccttgttacc gcctcttcgc
     7261 cagaaaatga aagcagggaa tagcatccgg gtaagtccgt aatacaaaat cttgcgtctt
     7321 tgattttgga acaacctctg gcaaactcaa ctgttttacc cgtccagttt cccgtgtgct
     7381 gtcttaatcc cgtcagttcg ttaaaaattg tactcttgcc gacattagga ttaccggcaa
     7441 gagaaatttt gtaatcgcaa tccgagacat cctttttatt aaaagatgat ttatccgtag
     7501 aaaacaataa aaaagcctcc ttttattcag gagtaacaat gatatctttg caatcgttat
     7561 ttctcagtgc cacaacggca tttttaacaa gatacgcaga cggatcaccg aacggacttg
     7621 taaacaaggg gataacagaa ctgttctcca taataccgaa atcaaatatt ctgtttttga
     7681 tattttcatt acagttcaca cgatagacaa tccccgtaac tccaagcggt aacttgtcaa
     7741 gcgaacattt ttctttcatc tgattcaccg atttcaactt tttattaaca gcatattcaa
     7801 ttcatacaac tgagttacac aaaaagccgg ccataaacta aacttatatc gtacccgaat
     7861 aaactctgat atcagaaaaa ttttaaggaa
//
