LOCUS       c00001_gnlPro..        13816 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCOCNJEC_1.
ACCESSION   c00001_gnlPro..
VERSION     c00001_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:42:55
            Original ID  :: gnl|Prokka|LCOCNJEC_1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1544
            Orig. end    :: 15360
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13816
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11544:14793]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..13816
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13816
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             14..1495
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MNNIPVVKLGLIAVSRDCFPIQLSEKRRAAIKETYKGELYECPVT
                     VENEKDMEKALEDVKKAECNALVVFLGNFGPETPETLIAERFDGPCMYVAAAEGDGDMI
                     NGRGDAYCGMLNCSYNLKMRHLKAYIPEYPVGTADDIAKMIADFVPVARAVIGVSNLKI
                     ITFGPRPQDFFACNAPIKGLYELGVEIEENSELDLLVSFKEHENDPRIPEVCADMAKEM
                     GEGKYYADLNVKMAQFELTLLDWAEAHKGARKYVAFADKCWPAFPSQFGFEPCYVNSRL
                     ASRGIPVSCEVDIYGALSEYIGLCISNDAVTLLDINNSVPQYIYDEDIKGKYDYKLTDT
                     FMGFHCGNTPACKMCDSRAVKYQLIQHRLLEPAGSEPDFTRGTLEGDIAASDITFYRLQ
                     CNSEGELVSYVAEGEVLDVPTRSFGGIGIFAIKEMGRFYRHVLIEGNYPHHGAVMFGHY
                     GKAFYEVVKFLGLDVKKIGYNQPAGVRYPTENPWG"
     CDS             1640..3097
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="FGGY_C (E-value: 1.7e-38, bitscore: 122.0,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 1.9e-80, bitscore: 259.6,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFTQSMEGMKELTKDIDRAQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSEAVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENQVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARSLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
     CDS             complement(3209..4144)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_5"
                     /sec_met_domain="LysR_substrate (E-value: 5.9e-34,
                     bitscore: 106.9, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.4e-19, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFEHYIYQKEQ
                     LLLAVPKNYSVNTRLQEYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             4260..5684
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="Lyase_1 (E-value: 2.8e-95, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 1.1e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             complement(5793..7478)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_7"
                     /sec_met_domain="FTHFS (E-value: 5.3e-276, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             8541..9998
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_8"
                     /sec_met_domain="OKR_DC_1_C (E-value: 5.3e-14, bitscore:
                     42.4, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 6.6e-127,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQTAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEHLQVLKGGI"
     CDS             10001..10861
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_9"
                     /sec_met_domain="Spermine_synth (E-value: 3.7e-54,
                     bitscore: 172.6, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 5.5e-16,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             10858..12138
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_10"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 4.6e-44, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 3.9e-36,
                     bitscore: 113.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKIDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKEAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             12128..13249
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_11"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.8e-15,
                     bitscore: 45.7, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIEQLQTPCYVIDEKKMRENLEILKKVQEDTGCKVLLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGHEEMGKENHVFSPAYHTEDMEELDRICDHIIFNS
                     TAQLKKFKEVCTRASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDVECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLVLDASAACHMPDVLEMPYRP
                     PLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTF
                     NGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS"
     CDS             13197..13814
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAD_porph"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_12"
                     /sec_met_domain="PAD_porph (E-value: 8.5e-53, bitscore:
                     169.3, seeds: 436, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRLSDISDTKTLRAGFPDICLTIREKETDMEVIEKNRTKYRMPGE
                     FEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSKAQMENAKNQLG
                     NVSGLTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGDFDGLYRNWEKDDRV
                     AAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQ"
ORIGIN
        1 aggaatttat attatgaaca atataccagt agtaaaactt ggattaattg cagtaagccg
       61 tgactgtttt ccgattcagc tttctgagaa gagacgtgca gcaatcaagg aaacttataa
      121 aggtgaactt tatgaatgtc ctgtaactgt tgagaatgaa aaggatatgg agaaagctct
      181 tgaagatgta aaaaaagcag agtgtaatgc gctggttgtt ttccttggaa acttcggacc
      241 tgaaactcct gaaactctga tcgcagagag atttgacgga ccttgcatgt atgtagcagc
      301 agcagaaggt gacggcgata tgatcaacgg cagaggtgat gcttactgtg gtatgcttaa
      361 ctgctcctac aacttaaaaa tgcgtcatct gaaagcatat attccggaat atcctgttgg
      421 aacagcagat gatattgcaa agatgatcgc tgatttcgta ccggttgcac gtgcagtcat
      481 cggtgtcagc aatcttaaga tcattacttt cggaccacgt ccacaggact tcttcgcatg
      541 caacgcacct attaaaggcc tctatgagct gggtgttgag attgaagaga actcagagct
      601 tgatcttctt gtttctttca aagagcatga aaatgatcct cgtatcccgg aagtttgtgc
      661 agatatggca aaagagatgg gcgaaggcaa atattatgct gaccttaatg tgaaaatggc
      721 acagtttgag cttacacttc ttgactgggc agaggctcat aagggagcaa gaaaatacgt
      781 tgcatttgct gacaaatgct ggcctgcatt cccgtcacag tttggatttg aaccttgcta
      841 tgtaaatagc cgtctggctt ccagaggaat cccggtatcc tgtgaggttg atatctacgg
      901 agcactcagc gagtacatcg gactttgcat ttccaatgat gcagttacat tgcttgatat
      961 caacaattct gttccacagt atatctatga tgaagatatc aaaggaaaat acgattataa
     1021 gcttactgat acatttatgg gattccattg tggaaatact cctgcatgca agatgtgtga
     1081 ttccagagct gttaaatatc agctgatcca gcacagactt cttgagccgg caggatctga
     1141 accagacttc acaagaggaa ctcttgaagg tgatatcgct gcatctgaca ttacattcta
     1201 tcgtttacag tgcaattccg agggcgagct ggtttcttat gttgcagaag gtgaagtact
     1261 ggatgtacct accagatcat tcggtggtat cggtattttc gcaatcaaag aaatgggaag
     1321 attctaccgt cacgtactga tcgagggcaa ctatccgcat catggagcag ttatgtttgg
     1381 acattacgga aaagcattct atgaggtagt gaaattcctt ggactggatg ttaagaagat
     1441 tggatacaac cagcctgcag gtgtaagata cccgacagag aatccatggg gttaatgaga
     1501 aatcagtaaa acggattatt aatgttcatg tgaagtgaat gaatctgaat acagaataaa
     1561 taaactgaca ctatattaaa ggcatcccgg ggctttgctc tgggatgtat tagattagaa
     1621 atagaaaagg agagcactta tgtattatat tggtattgac cttggtactt ccgctgtaaa
     1681 acttcttctt atggaagaat caggaaaaat ctgtaacatc gtatccagag aatatccttt
     1741 attcttccca catccgggct ggtctgagca gaaaccggaa gactggttta cgcagagtat
     1801 ggaaggcatg aaagagctga caaaggatat cgacagagcg caggtagcag gaattggttt
     1861 tggcggccag atgcatggtc ttgtaacact tgacaaggat gataatgtga tccgtcctgc
     1921 aatcctctgg aatgacggac gtacaggcga agagacagaa tatctgaata cagtgatcgg
     1981 aaaagacaaa ctttcacagt atacagcaaa tattgctttc gcaggcttca cagcaccgaa
     2041 gatcctctgg atgcagaaaa atgagcctga gaactttaag aaggtagtaa agattatgct
     2101 tcctaaggat tatctggcat atcgtctgtc cggttctttt tgtacagatg tttctgatgc
     2161 ttccggtatg cttcttcttg atgtgaagaa ccgctgctgg tcaaaagaaa tgctggagat
     2221 ctgtggaatc acagaagagc agcttccgaa actgtatgag agttgggaag tagtaggaac
     2281 tctgaaacct gagattgcga aagagcttgg attcagtgaa gctgtaaagg ttgttgcagg
     2341 tgcaggtgac aatgcggcag ctgctgtagg aacaggtaca gttggtgacg gtcagtgtaa
     2401 tatttctctt ggaacatccg gaactgtgtt tatttccagt aaaaactttg gtgtggacga
     2461 aaataacgca cttcattctt tctgtcatgc agatggaagc tatcatctga tgggatgcat
     2521 gctcagcgca gcttcctgta acaaatggtg ggcagaggag attcttcaga caaaggattt
     2581 cgcagcagag caggctccaa ttcagaagct gggagagaat caggtattct tccttccata
     2641 tctgatggga gagcgctcac ctcataataa tcctgatgca agaggtgtat tctttggaat
     2701 gtccatggac agcacaagag cagacatgac acaggctgtt ctggaaggtg ttgcctttgg
     2761 tcttcgtgat tccctggaag ttgcaagaag ccttggaatc aagattgaga gaaccaagat
     2821 ctgcggtggc ggagctaaga gcccactgtg gaagaagatc attgcaaacg ttatgaacct
     2881 gaaggttgat gttctggaga acgaagaagg accgtccatg ggtggagcta tgctggcagc
     2941 agtaggctgt ggtgcttatc cggatgtaga aactatcggt aagaaatttg ccaaagttgt
     3001 tgatacagta gaaccggatc ctgaactggt tgcaaaatat gaagagagat atcagaagtt
     3061 cagaactctg tatccggcga tgaagccatt attctaatcg aatatctgcc tgacatactg
     3121 gggttgttgt gcttatttag cacaacaacc ccattttgac gtacatctga tgatgaccaa
     3181 tcaccacagc ctatttgatt atggcatatc aggaaaaggg cagcttcagg aattcttcca
     3241 tggctctgct gatatagcgg cctttcttcc agtaaaaaaa cacagtgcgt ttactgctct
     3301 gaccgggcag cttataaaaa acaagttctg aatttgttgg aactctggag agcagaagat
     3361 ccccgatgaa agtgataccc attcccaaac atgcaatatt ataggcagtc atctgctgat
     3421 ccaggcgaaa tactacagaa ggcgaaaagt gattttcctg acaaatggta agtgcacgct
     3481 taccggtatc attatctgaa cgaagaataa taaatggttc gttctcgaat ttgtttaatg
     3541 gaacagaagg aatatgagaa gaacggaact gcccgttccg gatttcctca ataggaatct
     3601 gatattcctg cagtctggta tttactgaat aatttttggg aaccgctaga agaagttgtt
     3661 ctttctggta gatataatgt tcaaaaatct ggttatccag aatacagtta tcaatcacca
     3721 gatctaactt tccggcctgg agaaactggg atagctttgc tgtactttct tctacaagag
     3781 aaatttgaac atgggggaat ttttgggaaa aatcagcaat aaggggaggc agaatccacg
     3841 aagaaaaaaa gttactgcca cctacattaa gagttcctgt tttgagattt cccagatcca
     3901 gtaggtagtt ttcgagatta ttttcaatat ccatgacttt ttcaacagcc tgtatataat
     3961 gttttccgac ttcagttaac tgtaaaggtt tggtacttcg atcaaaaata ggataaccaa
     4021 tgcggttttc cacacgtttt acatttgcac ttaaagaagg ctgcgaaatg aaaagagcag
     4081 cagcagcttt ggaaaagctt ttttccttgt atacctcata gatgtattcc attccctgaa
     4141 acatataaac tcctccgata tataacttaa acactatata ttttataaaa atatatgtat
     4201 ttgattatat tatagcagag atatataatg agggcaaata catgggaggg cgaataacta
     4261 tgaaaaaaac agactatcgt gtagaaaggg attctattgg tgtaaaggat attccggaag
     4321 atgtatatta tggagtacaa tccttacgtg cggctgaaaa tttccacatt acggggctga
     4381 atatgcatcc ggaaattatt aacagtcttg catacataaa aaaagcagca gcgataacca
     4441 attgtgaggt ggggcttctt gagaagaaaa aagcacaggc gattgtccag gcatgtgatg
     4501 aaattgtttc aggaaaattc cataatgaat ttattgtgga tcctgttcag ggaggagctg
     4561 gcacatcttt aaatatgaat gccaatgaag taattgcaaa tcgcgcgatt gagatactgg
     4621 gaggaaaaaa gggcgattat acaattataa atcctaacga tgatgtgaat tgtggacagt
     4681 ctaccaatga cgttattcct actgccggta aaatgacttc tcttcgtttg ttgcagaatc
     4741 tgaaaaaaca gcttcttcgc ctctatgatg ctcttaatga aaaagctaca gagtttgatc
     4801 acataataaa aatggggcgt acacagatgc aggatgcagt accaattcgt ctgggacagg
     4861 aatttaaggc atattcggta gcaatcatgc gtgatatcca cagaatggat aaagcaatgg
     4921 atgaaatgcg gactcttaat atgggaggta ctgctattgg aacaggaatt aatgcagatg
     4981 agggctatct gagaagaatt gttccaaatc tcactgaaat atcgggaatg gactttatac
     5041 aggcttttga tctgattgat tccactcaga atctggatcc atttgtagcc gtttccggtg
     5101 ctgtgaaagc atgtgcggta actctttcca aaatgtcaaa tgatctccgt ctgatgtcct
     5161 ccggtccacg tactggtttt ggggagatta atcttccggc aaaacagaat ggttcctcta
     5221 ttatgccagg taaagttaat ccggttattc ctgaagtagt gaatcaggtt gcttttaata
     5281 ttattggtaa tgatgttacc attaccatgg ctgcagaggc tggtcagctg gaattaaatg
     5341 cgtttgagcc gattattttc tattgcatgt tccagtctat cgatactctt ggctatgcag
     5401 tccagacatt ggtggataat tgtattgtag gaattacggc aaatgaagaa agatgccgtt
     5461 atctggtaga aaacagtgta ggtattatca ctgcaatcag cccccatctt ggatatcaga
     5521 aggctgcgga tattgcaaaa aaggcaatta agacaggcga atctgtaaga agtctgattt
     5581 tgaaagaaaa gcttatggac gaggatgaac ttaatcgcat tctggatccg atccatatga
     5641 cggaacctgg tatttccgga aaagattatc ttataaaaaa ataaagaaaa aaacaggcgg
     5701 gaaaatcttc ccgcctgtaa aatcgtctgg acacatatca tatataaata tgatttttat
     5761 atttttgaat tattcgattg atttcaaccg gattagaaca gacctgtgat cttacctgtc
     5821 tcgtctacgt cgattctctc agcagccgga actttaggaa gacctggcat tgtcatgatc
     5881 tcacctgtaa gagctacgat gaatcctgca ccagcggaaa tcttcaggtt acgtactgta
     5941 acttcgaagt cagtaggagc acccagtttg gtctggtcat ctgttaagct gtactgagtc
     6001 ttagctacac agatcgggca gttgccgaat ccaagagctt ctaactgttt cgcctgtttc
     6061 tgagcgttag ctgtcagaac tactttctta ccgccatata ctttctgaac gatctggttc
     6121 agtttgtctt cgatagaacc ttccagttca tatgcatagg agaagtcgtt tggttcttca
     6181 acaagacgga taacttcttc tgcaagtttg attccgcctt cgccgccttt tgcccatact
     6241 tcagaaagag caacgttaac gcccagttct ttacatttag cttctacaaa gtcaagctct
     6301 gcttttgtat ctgtagggaa tgcgttgata gcaacaacac atggaagttt gtatacgttt
     6361 ttgatgttgg aaacgtgttt taacaggttc gggatacctt tttcaagagc ttccaggttt
     6421 tcattgttaa ggtcagcttt agcaacgccg ccgttgtatt tcagggcacg tactgtagct
     6481 acgattacaa ctgcgcttgg ttttaaacca gccatacggc atttgatatc aaggaatttc
     6541 tcagcaccaa ggtcagcacc gaaaccagct tctgtgattg cataatcagc aagcttcata
     6601 gccatctttg tagctgttac agagttacat ccatgagcga tgtttgcgaa tggtccgcca
     6661 tgtacgattg caggaacgtg ttccagagtc tgtacaaggt ttggtttcag agcatctttt
     6721 aacagggctg tcatagcgcc ttctgcgtga aggtcacctg ctgttacagg tttctgctcg
     6781 gaaacttttc cgtatgtata tccgatgatg atcttggata atctttcttt caggtctttg
     6841 atgtcgcttg caagacagag aactgccatg atttcagatg caactgtgat gtcgtatccg
     6901 tcttcacgag gcataccgtt tgtctttccg ccaagaccat ctactacgtt acgaagctga
     6961 cggtcgttca tatctacaca tcttctccat gtgatcttac gtgggtcgat gtttaatgca
     7021 ttgccctgga agatatggtt atcgatcata gctgccagta agttgttagc tgcgccaatg
     7081 gcatggaagt cacctgtgaa gtgaaggtta atatcttcca taggaacaac ctgtgcatat
     7141 ccgccgcctg ctgcaccacc ttttacaccg aataccggtc ctaaggatgg ctcacgaaga
     7201 gctaccataa cactcttgcc aagtctctgc ataccatctg caagacctac agtagtagta
     7261 gttttacctt ctcctgctgg agttgggttg atagctgtaa cgaggattaa ttttccatcc
     7321 ttcttatcac tttctttcag aagattgtag tcgatttttg ctttgtattt tccgtactgc
     7381 tccagatatt tgtcgtcaat acctgctttc tctgcgatct gagtaattgg aagcatctcg
     7441 cattcctgtg caatttcaat gtctgatttg aatcccataa ttgtttttct cctttcgttt
     7501 ccgcataaca tgaaaaactt ctgttgctgt tcactccgcg atcagcaaca attattaatt
     7561 gaaagaagta ttggccggtc tgcctggtat tcctgatttc tgccctgaaa gttataaaaa
     7621 aaggccagta tctgaatatt tcaaatactg cccagacggt cggctcccac aaacctccga
     7681 ctccacgtgg tttgcactcc actctttccg tcagtactcg aaggttcttt caattgatga
     7741 atacaatata tcattttgag aaaaaaatgt caagaaaatt tttgttgaaa cgtcaaaaaa
     7801 tgtgagtaaa ctggataaaa gttgtgcaaa ttgataagag aagagaatcg taatccctgg
     7861 taatgaaaga aaatacgttt tctcaaggga agaaattgtt aaaaaataga cacagttttc
     7921 cctgataaat gaagaaaata taaaaagcgg gtaaagactg tgcaaaatat ggaaaatgga
     7981 attgacaaca gttcagaaga tatgttattc tcatctttag tatgaaaaga cactatcgtt
     8041 ttcatgcaaa tatttgctca cattcagaga cagtttctga atgttaagcc atacggacag
     8101 gcggggcagt tgccgggtgg gagacaccac attattgatt gagttagaag ctcaaatttt
     8161 ataagttgat tactttataa taatcagtgc gtaagcacac atcatcttgt gaaacggtca
     8221 ataagagcat agcatatatt tgccagcgat tgaagacgac agcagtcatg aatatttcag
     8281 aatacgggaa caggcacagg atacagacgg atttatacgg gaaatccggt cagtatataa
     8341 agagacagag cctgagaaat tctatagatc atgagagaag cagatggtga atgaacttat
     8401 ctgcttcttt ttttgtgcag atatagcaaa tatatagaga aataattgaa tcattgtgcc
     8461 ggtttgaggc agtatacaat tgctgaatga tagaactgta tttgccggta catgacgaca
     8521 ggaaaagagg aacatgtcaa atggattatg aaagacaaca gcatgcgccc atatatgaag
     8581 cactggaacg tttccgaaag aagagagtcg ttccctttga tgtgccggga cataaaagag
     8641 gaagaggaaa tccggagctt gcacagttgc tgggagagaa atgtgtgggg ctggatgtta
     8701 attctatgaa gccgctggac aatctctgcc acccggtttc ggtgatcaga gaagcggagg
     8761 agcttgcagc agatgctttt ggcgcagcgc atgcattcct tatggtagga ggaaccacat
     8821 ctgcagtgca gagcatgatc ctgtctgtct gcaaggcagg ggataagatc attctgccgc
     8881 gaaatgtaca taaaagtgcc atcaatgccc tggtactgtg cggtgcaatt ccggtttatg
     8941 taaacccgga ggtgaatgcg cagctgggca tttcccttgg catggaagtc agtcaggtgg
     9001 agaaggctat ggatgagaat ccggatgcgg tggcggttct tgtaaataac cctacctatt
     9061 atggaatctg ttcggatctg cggactatcg taaagaaggc tcatgcaaga ggaatgaagg
     9121 tgctggcaga tgaggctcat ggaacccatc tttatttcgg cagaaacctt cctgtatccg
     9181 gaatggcggc aggtgctgac atggcggcag tttccatgca caaatccggc ggaagtctga
     9241 cacagagttc gctgctgctt ttgaataaga gtatgaatgc agagaaagtg cgccagatca
     9301 tcaatctgac tcagaccaca agtgcttctt atcttctgtt gtccagtctg gatatctcca
     9361 gaagaaatct ggcactcagg ggagaggaat cctttgaaaa ggttgcaggg atggcgcagt
     9421 atgccagaga ggagatcaat gagatcggcg gctattatgc atatggtatg gatctgatca
     9481 atggaaccag tgtttttgat tttgatgtta caaaactctc catttataca ttgggaaatg
     9541 ggctggcagg tattgaagtt tatgatcttc tcagagatga atatgatatt cagatcgagt
     9601 ttggagatat ctgtaatatt ctggcttaca tttccatcgg agacaggctt caggatattg
     9661 agagactggt aggggcattg gctgatattg aacgtctgta taagaaggac agcacaggta
     9721 tgctttccgg ggaatatatc gcacctgcag tggtggcgtc tccacagcag gcgttttatg
     9781 cggagaaaga atctctgccc atggaacaga cggcaggcag gatcagcggt gaatttgtta
     9841 tgtgttatcc tccgggaatc ccgattcttg ctcctgggga aatggtgaca caggaaattg
     9901 tagaatacat tctttatgca agagacaaag gctgttccat gcagggaatg gaggatccga
     9961 aggtagaaca tcttcaggtc ctgaaagggg gtatctgatc atggaattat ggtattccga
    10021 gttccataca ggaaatgtaa agctttctgt ccggattaac cgacagttat tttcagggga
    10081 aagtgaattt cagagaatcg atgtgtttga gtctgaagaa tttgggagat ttgtggctct
    10141 ggacggtgag attgtattct ctgataaaga tgaatttatt tatgatgaga tggttacgca
    10201 tgtgccaatg acagtacatc ccaatgtaaa aaatgttctg atcatcggcg gcggtgacgg
    10261 tggagttgcc agagaactga tccattatcc acagattgag agcattgatg tggtggaatc
    10321 cgataaaatg tttgtggatg tatgtgcgga gatgtttccg gatattgccc agggactgaa
    10381 ggatgagaga gtcaacattt attatgaaga cggccttcgg ttcctgcgga ataaaaaggc
    10441 cagatatgac ctgatcatca atgattccac agatccgctg ggacatacag agggactttt
    10501 tacaaaggaa ttctacggaa gctgttataa ggctctcaga gatgacggaa tcatggttta
    10561 tcagcatgga agtccttttt atgatgagga tgaggtggaa tgcagaaaga tgcacagaaa
    10621 ggttttccgg tcatttccgg tgagcagggt ttatcaggca catatcccta cctgtccctc
    10681 gggatactgg ctttttggat ttgcatcaaa gaaatatcat ccactggaag atttcaggcc
    10741 ggagaggttt gataatctta atatagaaac atggtattat acaacaaacc ttcacagagg
    10801 agcatttatg cttccaaaat atgtagaaga tttactggaa gaggaggaaa acagtttatg
    10861 agcagattat tggtaattgg atgtggtggg gtagcttcag tggcaattcg caaatgctgt
    10921 cagaatagcg atgtttttac agagattatg atcgcaagca ggacaaagga aaaatgcgat
    10981 gcactcaaag agaagattga aagtacaacg aagacaaaaa ttgagacagc aaagatagat
    11041 gcggataatg cagcagaggt cgcagaattg atcagagcct ataagccgga tgctgtcctg
    11101 aatgtggcac ttccatatca ggatcttacc atcatggatg catgtctgga agccggtgcg
    11161 gattatattg atactgccaa ttatgaagca gaggatacag aagatcccac atggcgtgca
    11221 atctatgaaa agagatgtaa agaaaaaggc tttactgcat atttcgatta ttcctggcag
    11281 tgggcttatg atgagaaatt taaggaagca ggactgactg ctcttctggg aaccggtttt
    11341 gacccggggg ttaccagtgt attcagtgct tatgccctga agcattattt tgatgaaatc
    11401 cataccattg atattctgga ctgtaacggc ggtgatcatg gatatccttt tgccacaaac
    11461 tttaacccgg agatcaatct tcgagaggtt tccgcaaatg gttcctactg ggaagacgga
    11521 cactgggtag aaacagagcc tatggaattt aaatctgtct acgatttccc tgaggtagga
    11581 aagaaggata tgtatcttct tcatcatgaa gagattgaat cactggcaaa gaatattccg
    11641 ggagtacaga gaatccgttt ctttatgaca ttcggacaga gctatctgac acatatgaaa
    11701 tgtctggaaa atgtaggaat gctttccacc gcacctgtgg aatttaacgg acaggagatc
    11761 gtgccgatcc agtttttgaa agctcttctg ccggatccag catctctggg accgagaaca
    11821 gtgggtaaaa caaatatcgg ctgtattttc acaggtgtta aggacggaaa agagaaaagt
    11881 atctatattt ataatgtatg tgatcatcag gaatgctata aagaggtgga atcccaggca
    11941 atttcctata caacaggtgt tccggccatg atcggttcca tgatggtagt gaccggacag
    12001 tggaagaagc cgggtgtatt taatgtggaa gaatttgatc cagatccata tatggaagca
    12061 ctgaacaaat ggggacttcc atggaaagtc tgcgaagatc ctgaactggt aaaggtctgg
    12121 aaagctaatg aagattgagc aactgcaaac tccctgctat gtgatcgatg agaagaagat
    12181 gcgggagaat ctggaaattt tgaaaaaagt ccaggaggac accgggtgta aggtccttct
    12241 ggcacagaaa gcgttttccg gctttgccct gtatcccatg atcggaaaat atctggcagg
    12301 taccactgcc agtggtctgt ttgaggcgag gcttggacat gaagagatgg ggaaagagaa
    12361 tcatgttttt tcccctgctt accatacaga agatatggag gaactggacc ggatctgtga
    12421 ccatattatc tttaattcta cagcacagct gaagaaattt aaagaggtgt gtaccagagc
    12481 cagtctggga ctccgtatta atccggaatg ctccactcag ggggatcatg caatctatga
    12541 tccctgtgca ccgggttcca ggctgggggt taccagagag aactttgacg tggaatgtct
    12601 gaaatggatc gacggactgc attttcatac gctctgcgaa cagaatgcgg atgacctgga
    12661 gaaaacattg caggcggtag aggagaagtt tggagaattt ctgtctgagg tttcctggct
    12721 gaatatgggc ggcggacatc atattaccag agaggattat gatgtaaagc tcctggaaaa
    12781 atgtattcag catatgaagg aaacctatga tctggatatt tatctggagc ccggggaggc
    12841 tgttgccctg aatgccggat atctggtgac agaggttatg gacattgtgg aaaatgagat
    12901 cagaacgctg gttctggatg cttctgcagc ctgccatatg ccggatgtgc tggaaatgcc
    12961 ctatcgtccg cctcttaaag acagcgggga agcaggggag aaggcatata cctaccgctt
    13021 atcttcctgc acctgcctgg caggagatgt aatcggagat tattcctttg acagagagat
    13081 ccggatcggg gacaagctgt attttatgga catggcgatt tattctatgg tgaaaaataa
    13141 tacatttaac ggtatgccgc tgccggatat tgcggttatg catgaggacg gagagtgtga
    13201 ggttatcaga catttcggat acgaagactt taagagccgg ctttcctgat atctgcctga
    13261 ctatcagaga aaaggagaca gacatggaag ttattgagaa gaacagaaca aaataccgta
    13321 tgcccggaga atttgagcct catgagggat gcgtgatgat ctggccggaa cgtcccggtt
    13381 cctggaatta tggtgcaagg gaagcgcaga aagcatttgt taaagttgca gaggctattg
    13441 gagagagcga aaaggtgtat atgctggttt ccaaggctca gatggagaat gcaaagaatc
    13501 agcttgggaa tgtttcgggt ttgactttgc tggaatgcga gacagatgac gcctgggcca
    13561 gagatgtggg agcaaccatg gttctggatg agaaaggggc ggtctgtgga gttgactggc
    13621 agtttaatgc ctggggagga gactttgatg gactttaccg gaactgggag aaggacgaca
    13681 gggtggctgc ctttatctgc aggactcttg gttgtccatg tctggatgcc agaccttttg
    13741 tgcttgaggg cggttccatc cattctgacg gagaggggac tctgatcgtt acagaggcct
    13801 gtcttctgag tcaggg
//
