LOCUS       c00007_gnlPro..        14071 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCOCNJEC_7.
ACCESSION   c00007_gnlPro..
VERSION     c00007_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 00:42:55
            Original ID  :: gnl|Prokka|LCOCNJEC_7
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14071
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14071
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1476:5718](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1477..5718
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14071
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14071
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(2..1030)
                     /locus_tag="ctg7_1"
                     /transl_table=11
                     /translation="MAEYKLLKTEGRAKRAEFHTVHGTIQTPVFMNVGTIGAIKGAVST
                     MDLQQIGTQVELSNTYHLHVRPGDKIVKQLGGLHKFMVWDKPILTDSGGFQVFSLAKLR
                     KIKEEGVYFNSHIDGHKIFMGPEESMQIQSNLASTIAMAFDECPSSVADRDYVQKSVDR
                     TTRWLARCKAEMARLNSLPDTINKEQLLFGINQGAVYEDIRIEHAKAISEMDLDGYAVG
                     GLAVGETHEEMYRILDAVVPYLPQNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNG
                     RHGHVYTNHGKMNLFNAKYELDTRPIEEGCQCPACQHYSRAYIRHLLKAKEMLGMRLCV
                     LHN"
     CDS             1477..5718
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_2"
                     /sec_met_domain="HGD-D (E-value: 6.7e-64, bitscore: 205.8,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 7.3e-38, bitscore:
                     119.8, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKTLGIDIGSTTVKIAILDENENLIFADYKRHFANIQETLADL
                     LQEAFDQYGEMTLHPVITGSGGLTLANHLGVPFTQEVIAVSTSLQKLAPKADVAIELGG
                     EDAKIIYFENGNVEQRMNGICAGGTGSFIDQMASLLQTDATGLNEYAKDYKALYPIAAR
                     CGVFAKTDIQPLINDGATKPDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLHFLS
                     ELRESFIRTLKLDEEHTIIPENSHLFAAIGSALNAKEDNSISLTEMKDRLRNSIKLDFE
                     VERMEPLFASQEEYDAFAKRQSSYKVKTGDLATYKGNCYLGIDAGSTTTKTALVGEDGT
                     LLYSFYSSNNGNPLKTTIRSIKEIYELLPKDAKIAYSCSTGYGEALIKAALLLDEGEVE
                     TVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTVDSVQLNEACSSGCGSFIETFAKS
                     LNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQAQKEGAEVSDISAGLAYSVIKNAL
                     YKVIKVSDASELGKHIVVQGGTFYNDAVLRSFEKIAGCEAIRPDIAGIMGAFGAALIAR
                     ERHQEGAETTMLSIDKINELKYTTSMANCRGCTNNCRLTINKFSGGRQYVSGNRCERGI
                     GKEKNKDHIPNLYEYKYKRIFSYTPLTADKASRGKVGIPRVLNMFENYPFWYTFFTELK
                     YEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGHVTWLIRNGVKFIFYPCIPYERNE
                     FPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRNPFLAFTSEEILANRLVEEFKDIP
                     AEEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDTGRHGIVLAGRPYHIDPEIHHGIP
                     DLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHSRLYAAANYVKTRDDLDLIQLNSF
                     GCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGAARIRIRSLIAAIRAKKAQGQKRT
                     VKPASIDKVSFTKEMRKDYTILCPQMSPFHFSLLQAAFNSCGYNLEVLPNDNKHAVDVG
                     LKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVVMSQTGGGCRASNYIAFIRRALKK
                     AGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGAVFGDILMKCVYRMRPYELEEGIV
                     NRKHKIWEQRVISFLSGSSISHSQFKKMCREMVHEFDTIPISDVKKPRVGIVGEILVKF
                     LPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQNFKVENLGFKKSKATMANWGIKAI
                     EWVRKPASEALAQSRHFAPPADIRDLAKMASPIVSTGNQTGEGWFLTGEMMELIHGDVP
                     NIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAIDYDPGASEVNQLNRIKLMLSTAQ
                     KNLKKAEEKNA"
     CDS             complement(5945..7573)
                     /locus_tag="ctg7_3"
                     /transl_table=11
                     /translation="MNQKNNLVKNASFLMIAAMISKVIGLLYKSPLSNIIGSLGMGYTS
                     LAQNAYMILLMIASFSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFC
                     LFGAGLIIPQNQKDAIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFN
                     AAVSLLAAWGFINAFSDGTENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILH
                     RVERDHRHQEESYKEIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQI
                     GILYAEYATYFMTIINIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVV
                     SAPCAMGLAVLAQPIVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRI
                     PVITAAIALVVDIVVVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPW
                     KEGYLYPVLASVPMGIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSE
                     SQLRRIPGGSYLIRIAEKLPFWQNN"
     CDS             complement(7619..8293)
                     /locus_tag="ctg7_4"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             complement(8326..9084)
                     /locus_tag="ctg7_5"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             complement(9086..9724)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_6"
                     /sec_met_domain="GATase (E-value: 3.4e-31, bitscore: 97.8,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYDAGNIKSVEKALHYLGEETTVTRDPQTLLNADKVILPG
                     VGSFGQAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTYVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK"
     CDS             complement(9970..11514)
                     /locus_tag="ctg7_7"
                     /transl_table=11
                     /translation="MTGNGKTDKKFHTLQHQISVVFICLLLLSIFTITLINGLFLEKYY
                     VSKKVEVLEEAKEVLSQMNLDDILQYDTDIEEDKKGATDEISDEIERSSSRNNLTWIIV
                     NEENSGYYYWGENNMAKMLRSKLFGYINNLDQDMQHSRVLKKTDTCTMWQVHDRFAGME
                     YVECWGQFDNGYYFLIRSPLESIKESASISNSFYFIVGIIIIVVSGIVILVMTNRITRP
                     ISELTKLSEKMSDLDFDARYQSRAGNEIDVLGDNFNKMSRKLESTISELKSANNKLQKD
                     IEDKIKIDEMRKEFLDNVSHELKTPIALIQGYAEGLNENISDDPESREFYCEVIMDEAS
                     KMNKLVKNLLTLNQLESGKDAPVMERFDIVSLIRGVLGSMHIMIEQKEATVIFEETEPV
                     YVWADEFKIEEVVTNYTSNALNHLDGERKVEIKVLQEEDCVKVTVFNTGTPIPEEDIPN
                     LWNKFYKVDKARTREYGGSGIGLSIVKAIIESMNQKYGVCNYDNGVEFWFTLDCRQ"
     CDS             complement(11511..12191)
                     /locus_tag="ctg7_8"
                     /transl_table=11
                     /translation="MDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGEEAMDIFYE
                     EKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDLGVDEYISK
                     PFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPMELSFKEFELLT
                     YFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKTVWGMGYKF
                     EVDE"
     CDS             complement(12982..13989)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_9"
                     /sec_met_domain="Fer4_17 (E-value: 4e-13, bitscore: 39.1,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 9.9e-05, bitscore: 12.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVTLGKTGLRVSRMGLGGIPIQKIDAEGTKTLLHKLADRGVNY
                     IDTARGYTVSEEYLGYALEGIRDRFIIATKSMARTKEAMAEDIEKSLHNLRTDHIELYQ
                     VHNPSMEQLDQVQAAGGALEALQEARAAGKIGHIGLTAHSVEVFARALELDWVETIMFP
                     YNIVESQGEELISKCEEKNIGFIDMKPLAGGAIENGTLALRYVCSNKNVTIVIPGMAEE
                     KEIEENIKACLDDSPLSEKELEEVQTVRNQLGTNFCRRCNYCAPCSVGIDISGVFLFAG
                     YLNRYGLGDWARNRYSSLAVKASACIECGKCETRCPYHLPIREMLKECAQQFGE"
ORIGIN
        1 gattgtgaag tacacagaga cgcattccca gcatttcctt tgctttcaga aggtggcgga
       61 tataggctct gctgtaatgc tggcatgcgg ggcactgaca gccctcttcg ataggacgtg
      121 tgtccagttc atattttgca ttgaacagat tcatttttcc atgattggta tatacatgtc
      181 catgacggcc gttacggctt ggatatacgc agtcaaagaa atcaattcct ctctcaacac
      241 cttccagaat atttgccggt gttcccacac ccatcaggta agtaggttta ttctgaggaa
      301 gataggggac taccgcatcc agaatcctgt acatctcttc atgggtttct ccaactgcca
      361 aaccgccgac agcatatcca tccagatcca tttcagagat cgctttggca tgctcaatac
      421 ggatatcttc ataaacagca ccctggttga ttccaaacag aagctgttct ttgttaatgg
      481 tatccggcag actgttcagt ctcgccattt ccgctttaca gcgggcaagc catcgtgtgg
      541 ttctgtctac agacttctgc acataatccc tgtcagccac actgctggga cattcatcaa
      601 atgccatggc aatagtggaa gcaagattgg actggatctg catactctct tccggaccca
      661 taaagatctt atgcccgtca atatgggagt taaaatagac tccctcttct ttgatctttc
      721 tcagctttgc aagggaaaat acctggaatc cgcctgagtc tgtaaggatt ggtttgtccc
      781 ataccataaa tttatgaagg ccacctaact gctttactat tttatcaccc gggcgcacat
      841 gaagatgata agtatttgat aattctacct gtgttccgat ctgctgtaaa tccatggtgg
      901 atacagcgcc tttaatcgca ccgatcgttc ccacattcat aaaaacagga gtctggatcg
      961 taccatgcac tgtatgaaat tctgcacgct tggcacggcc ttctgtttta agaagtttat
     1021 attctgccat tttttctctc ctcttgataa aaatcacttt ttctattata tcccgaaata
     1081 gctgaatttt caactgcaaa taaggtaatc attggtaaac tttcatattg tcttttccag
     1141 accattagcg tataatatta cggaatattc catatctgga aacagatatt taataggaaa
     1201 gaacaggata gatttttact gtttacttcg tgtccggcaa cacgctttgc atgatatcag
     1261 cagcaaacag taaagaaaat gttactgttc actccgttct cagtaacgta gccaaaattc
     1321 attccagatt gcctgcggca atggaatttt ggcttgtatg tctcgggatt ttggcatatt
     1381 catgccaaaa cacctcgcgg gatagtggtg tgtgaacagt aacaggaaaa ttttaatttt
     1441 gtttatatac aatacgagga ggcttgaatt tactttatga attacaaaac acttggaatt
     1501 gacattggtt ccactactgt aaagattgcg atcttagatg agaatgaaaa tctcattttc
     1561 gcggattaca agcgtcattt tgcgaacatt caggaaaccc ttgcagacct tcttcaggag
     1621 gcctttgacc agtatggcga gatgactctc catcctgtga tcacaggttc cggcggtctg
     1681 acccttgcca accatctggg cgttcctttt acccaggagg ttattgcagt ttctacttct
     1741 ctgcagaagc tggcaccaaa ggcagatgtt gccatcgagc ttggcggtga ggatgccaag
     1801 atcatttatt tcgaaaacgg aaacgtagaa cagcgtatga acggtatctg tgcaggcggt
     1861 accggttctt tcatcgacca gatggcttct cttctccaga cagatgccac aggtctgaat
     1921 gaatatgcca aagattacaa ggcactctac ccgattgctg cacgctgcgg tgttttcgcc
     1981 aaaacggata tccagccgct gatcaatgac ggtgcaacca aaccggatct gtcagcttct
     2041 attttccagg cagttgtaaa ccagaccatc tccggtcttg cctgtggaaa acccatccgt
     2101 ggacatgttg cattcctggg tggtccgctt cacttcctgt ccgaactgag agaatccttt
     2161 atccgtactt tgaagctgga tgaggaacac accatcattc cggagaactc ccatcttttt
     2221 gcagccatcg gttctgcatt aaatgcaaaa gaagacaact ccatttccct gacagaaatg
     2281 aaagacagac tccgcaattc cattaagctg gattttgaag tagaacgtat ggaaccactt
     2341 ttcgcttctc aggaagaata cgatgcattt gcaaaacgtc agagttccta caaagtaaaa
     2401 acaggagatc tggctacata taaaggaaac tgctatctgg gtattgatgc aggttccacc
     2461 acaaccaaaa ctgcactggt aggcgaagat ggaacacttc tctattcctt ttacagcagt
     2521 aacaacggaa acccgttaaa aactaccatc cgttctatta aagaaattta tgaactgctt
     2581 cccaaagacg caaagatcgc ttattcctgt tctacaggtt acggcgaggc tctgatcaaa
     2641 gcggccctgc tcctggatga gggcgaggtt gagaccgtat cccattacta tgcagctgca
     2701 ttctttgacc cagaggtaga ctgtatcctg gatatcggcg gacaggatat gaaatgtatc
     2761 aagatccgca acaagaccgt tgacagcgta cagttaaatg aagcatgctc ctccggatgc
     2821 ggttccttta ttgaaacctt tgccaaatcc ctgaattata cagtacagga tttcgcaaaa
     2881 gctgctgttt tcgcacagca tcctattgat cttggtacca gatgtactgt tttcatgaat
     2941 tccaaggtaa agcaggcgca gaaagaggga gctgaggttt ccgatatttc cgcaggtctt
     3001 gcttactctg ttatcaaaaa tgctctgtat aaggttatca aggtttctga cgcttccgaa
     3061 cttggcaagc acatcgttgt acagggtggt accttctaca atgatgcagt tcttcgaagc
     3121 ttcgaaaaga ttgcaggctg tgaagccatc cgtccggata ttgccggaat catgggtgcc
     3181 ttcggtgccg cactgattgc ccgtgaacgc catcaggaag gcgcagaaac gactatgctc
     3241 tccattgata agatcaacga gctgaaatat acaacttcta tggcaaactg tcgtggatgt
     3301 accaataact gccgtctgac tatcaacaaa ttctccggcg gccgccagta tgtaagcggt
     3361 aaccgctgtg agcgtggtat tggcaaggaa aagaacaaag atcatattcc gaatctttat
     3421 gaatataaat ataaacgtat tttctcctac acaccgctta ctgctgataa ggcatccaga
     3481 ggtaaagtag gtatcccgcg tgttctgaat atgtttgaga attatccttt ctggtatact
     3541 ttctttacag aactgaagta tgaggttgtg ctctctccta cttccaccag aaagatttat
     3601 gagctgggta ttgaatccat tccaagtgaa tccgaatgct accctgccaa gctcgcacat
     3661 ggccatgtaa cctggctgat ccgcaatggt gtgaaattta ttttctaccc ttgtattcca
     3721 tatgaacgta acgagttccc ggatgcagtc aatcactata actgcccgat cgttacctct
     3781 tatgccgaaa atatcaaaaa taacgtagac gaattaaatg atccgtccat taccttccgc
     3841 aatccgttcc ttgcatttac ttctgaggaa attctggcaa atcgtctggt agaggaattt
     3901 aaggatatcc cggcagaaga agtcaaagct gctgtgcata agggctggga ggaaatggct
     3961 gctgcacgcc gcgatgtaca gaaaaaaggg gaagaaaccc tgaaatatct ggaagataca
     4021 ggacgccatg gtattgtcct tgcaggacgc ccataccata ttgacccgga aatccatcat
     4081 ggtatcccgg atctgatcaa cagctatggt attgccgtac ttactgagga ttccatctcc
     4141 catctggcac ctgtggaacg cccgatccgc gtcaatgacc agtggatgta ccactccaga
     4201 ctgtatgctg ctgcaaacta tgtaaagaca cgcgatgacc tggatctgat ccagctgaac
     4261 tcttttggat gtggtctgga tgcagttact acagacgagg tttatgaaat ccttgacgga
     4321 agtgacaaaa tctatacctg cttaaagatt gacgaggtaa ataaccttgg tgctgcaaga
     4381 atccgtatcc gttccctgat cgcagcgatc cgcgcgaaga aagcacaggg acagaaacgt
     4441 actgtcaaac ctgcttccat tgataaagta tcctttacaa aggaaatgag aaaggactat
     4501 accatcctct gcccgcagat gtcaccgttc catttcagcc tcctgcaggc agcattcaat
     4561 tcctgcggat acaacctgga ggtgcttccg aatgacaata agcatgcagt ggatgttggt
     4621 ctgaagtatg taaacaatga cgcctgctat ccgtctctga tcgttgtggg acagatcatg
     4681 gatgctctgc tttccggtaa atatgacctg aacaaaacgg ccgttgtcat gtcccagaca
     4741 ggtggcggat gtcgtgcttc caactatatc gcatttatac gacgcgcatt aaagaaagcc
     4801 ggtatggaac agattccggt tatctctgtt aacttaagcg gtctggaaag caatcccgga
     4861 ttcaaactta cgcttccatt agtgaagaaa gttgcttacg gtgccgtatt cggagatatc
     4921 ctgatgaaat gcgtatatcg tatgcgtcct tatgaactgg aagagggaat cgtaaacagg
     4981 aaacataaaa tctgggaaca gcgtgtgatc tctttcttaa gcggaagcag tatcagccac
     5041 agccagttta aaaaaatgtg ccgcgaaatg gttcatgaat ttgataccat tccgatcagt
     5101 gatgtgaaga agcctcgtgt cggcatcgta ggtgagatcc ttgtcaagtt cctgcctgct
     5161 gcaaataatc atctggcaga gcttctggaa tctgaaggcg ctgaggcagt tgtaccggat
     5221 ctgatcgatt tcatgtgcta ctgcttctat aatcagaact ttaaggtaga aaatcttgga
     5281 ttcaagaagt ccaaggcaac catggcaaac tggggaatca aagcaatcga atgggtgaga
     5341 aagcctgcaa gcgaagctct tgcacagagc cgccattttg caccgcctgc tgatatcaga
     5401 gatctggcaa aaatggcatc tccgatcgtt tccaccggaa accagacagg tgagggatgg
     5461 tttctgacag gtgagatgat ggaactgatc catggagatg ttccgaatat tgtttgtatc
     5521 cagcctttcg gatgtctgcc gaaccacatt gtaggtaagg gtgttatcaa agaaatccgc
     5581 agagaatatc cgacagccaa tattgtagcc atcgactatg atccgggtgc aagtgaagtt
     5641 aaccagctca accgaatcaa actgatgctc tccacagctc agaaaaacct gaaaaaagca
     5701 gaagaaaaaa atgcataaat aataccgtaa tggatatatt gcaatgtatt ttaccttgca
     5761 atatatccgt cttagagcgt atttgaaaaa tcattcccgc aatctacata tcctgctttg
     5821 cgaaaagcat ttttcaaacg cgctcaaaaa aagagttata tttcagaaat tttaaatgtg
     5881 tttctatttc agaaatacat ttaaaccatg aaatataact cttttgtttt tataatttca
     5941 gtgtttaatt attctgccag aacggaagtt tctctgcaat ccttatcaga tagcttccac
     6001 ccggaattct tctaagctgt gattctgacg gcttgctgat gatcaggtaa gcaaacagat
     6061 aaacaaccgc agcaacagga atggaaacga tcagacaaat gaaattggat tttacaaaaa
     6121 tgttcagtcc atagcagata cagcctgcaa caattcccat gggaacagat gcaagaacag
     6181 gatacagata tccttctttc catggattct tatactgcag atatttcttc atggctctgt
     6241 catttaacac acatacaacc acagaataga tcaccattgc gatcagcagt gcgtaaactc
     6301 caaggtttgt agtaaacagc agcactacca ctaccacaat gtccacaacc agtgcgattg
     6361 cagccgtaat caccggaatc ctctgctgtc cgattgcctg cagaactcca ttggaaatat
     6421 ttgacattcc attgagcagg attgaaaaag aaccaaggat cagcaggttg gctgccagtc
     6481 ctgtggaatt tccgtaaagc aaaaatacaa tcggctgtgc aagcactgcc agtcccattg
     6541 cacatggggc ggaaactacc atagaaagct gtacggtctg gtcaatgcac tctctggtcg
     6601 cttcaatatc tccggtggca tatagagcgg aaacttccgg aatcatggaa gtaggtgccg
     6661 tactggacag cgtcagagga atattgataa ttgtcataaa gtaagtagca tactctgcat
     6721 ataaaatacc aatctgtgcc gcatctccac ctcttcttcc cagaatatcc gagaaaagat
     6781 acccattgat ataagcattt acattataaa caaaggcgct gagaatgatc ggcgaaacaa
     6841 ccaggatgat cacacgaaaa atctctttgt aggactcttc ctgatgtctg tgatctctct
     6901 ctacccggtg caggattttt ctgcggttta caccatatac cagaagcatg aatgccaatg
     6961 cagtcaccac tccggctccg gttcctactg tggaacctgc tgccccccat tttgcaatgc
     7021 tgttctctgt tccatctgag aatgcattga tgaatcccca ggctgccaga agactgactg
     7081 ctgcattaaa tacctgctca atgatctggg agatagatgt tggcatcata tttctgtatg
     7141 cctgaaaata tcctctgaat accccaagaa taccggacaa aaaaatcgtc ggagccagaa
     7201 tctgaagtgc cggaattgca tccttctgat tctgagggat gatcagtcct gctccaaaga
     7261 gacagaataa accgaccact ccgccaatca ccatggcata gatcatggca cctttaaaga
     7321 acttatgtgc atttctgtaa tccttcaggg caatacgctc ggagatcagt ttggataccg
     7381 cctgtgggat actaaaggat gcgatcatca gaaggatcat ataggcattc tgcgcaagac
     7441 ttgtatagcc cattccaagg cttcctataa tattggaaag gggactcttg tacagaagac
     7501 cgatcacctt ggagatcata gctgcaatca tcagaaagga tgcatttttt actaaattgt
     7561 ttttctgatt catgttatca ctgtgtgtct tttacctgac tacacattac ctcttttctt
     7621 atatattttc tatctgccag tcgattggtt ccagaccatt ggcaacaaga aattcgtttg
     7681 ttttactgaa atgtttacat ccgaaaaatc ccctgtaagc agacagagga cttggatgag
     7741 gcgcctccag aatcagatgc ttcggattat tcagcatgga ttttttcatc tgcgccggac
     7801 gtccccagag cagaaataca ataggacggt cctgctcatt cagaacctgg atcgcagcat
     7861 ccgtaaactg ctcccagccg atccccctgt gtgaatttgc ctgatgggcg cgtacagtca
     7921 gaactgtgtt cagaagaagc actccctgct tcgcccactt ctccagatag ccgttattgg
     7981 ggatatagca tccacagtca tcatgaagct cctgataaat attcaccagg gacggtggcg
     8041 tctccactcc tctctttacg gaaaaacaaa gcccatgagc ctgcccgtca ttatgatagg
     8101 gatcctgacc cagaatcact accttcactt cattcaacgg tgtaaaatga aatgcattaa
     8161 acagatcatc cgcaggagga aaaatcttcc tggtctgata ttctgtcatc accgttttat
     8221 ataatttcgc ataatacggc tggtgaaact cccccttcag ggcttccagc cagtcacctg
     8281 aaattgctga cataccttat ccttcacctc ttatattttt cgtggtcatc gtctgacaga
     8341 aattcccctg tcagacagat aatccttcac ctgagaaatc tccagttctt tataatgaaa
     8401 caaagacgca gccagtgcag catctgctcc cccttcggtc agtgcatcat aaaaatgctc
     8461 cagtgtacct gcaccgcctg atgcgatcac aggaatggag acagcatcag caattgctct
     8521 ggtaagagcc agatcatatc ctgcctttgt accgtcacag tccatactgg taagaaggat
     8581 ttcccctgcg cccaaagctt ccactttctt tgcccactct atggcatcaa tccctgtatc
     8641 cagtcttccg ccatgtttgt aaatattcca tcctccgtct tctctgcgct tggcatcaat
     8701 agccacaact acgcactggc ttccaaactt gtcagccgcc tcactgatca gttccggtct
     8761 gtcaattgct gcagaattta cggaaatctt atctgctcct tctctcagca gtttcttgaa
     8821 atcatctaca gtacggatac cgccgcctac tgtaaacggg ataaatacat tggcagcaac
     8881 ccgtcttacc atgtcaacta ccgtatctct ctgttcgcag gatgctgtaa tatcgagaaa
     8941 caccagttca tccgctcctg ctgcatcata ggctttggca atctccaccg gatcacccgc
     9001 atcgcgaagc tgcacaaaat ttacgccctt taccacacgt ccgttattta catccaggca
     9061 gggaataatt ctctttgtaa acatcttatt ttccctcctt ctcagtattg ccgtcttttc
     9121 ccacagcagc aaaattttca agtatcttca gtccccattt gctgctcttt tccggatgga
     9181 actggcaggc aaatacattg tccttttcta cggaagcatg aatacaggtg ctgtattctg
     9241 tagtagcctt tacaatctca ggctcctctg cctgcagata ataagaatgc acaaaatata
     9301 cataggtctg ttccgggatt ccctgaaaca gtctgccatt attctgaaaa tgcagggaat
     9361 tccatcccat atgtggaatc ttaagcccgg gcgcaggcgg aatcttaaca attttccctt
     9421 tcaggattcc aaggccttcc acacccggtg tctcctcgct gctttcaaaa aggagctgaa
     9481 gtcccaggca gattccaaga aatggcgtct tcttctctac aatctcatgg atcacaggta
     9541 caagtccgta tgtatgaaga ttctccatcg cctgtccaaa acttcccacg cccggcagga
     9601 ttactttatc cgcatttaac aaagtctgcg gatcgcgggt tactgttgtt tcttccccaa
     9661 gataatgaag tgctttttct acacttttaa tatttccggc atcatagtca attattgcaa
     9721 tcatgttatc ctcctgatgt cattatctgt tttcctcatt atggtaatcc aaagattttc
     9781 cggatcacat gtcagaccgg aataaaatat ccgatcaaaa cgctccaata cagtataacc
     9841 caaaaacaga cagttgcaaa gtgctttctt tgcttctgtc tgtttttatt ccgatcatac
     9901 taccggttac tgttcactcc attcacagta acacgcttct cactacgttc acaatacccg
     9961 gatatcttat cactgcctgc aatccagagt gaaccagaac tccacgccat tatcataatt
    10021 gcatacccca tatttctggt tcatactctc aatgattgcc ttaacaattg aaagtccgat
    10081 accacttccg ccatattctc ttgtccgggc cttatctact ttgtagaatt tattccagag
    10141 atttgggata tcctcttccg gaatcggagt acctgtatta aatacggtta ctttcacaca
    10201 gtcctcttcc tgaagaacct taatttctac ttttcgttct ccgtccagat ggttcagtgc
    10261 attgcttgta taattggtca caacctcttc aatcttaaac tcatccgccc atacatatac
    10321 aggttctgtt tcttcaaaaa tcacagttgc ttctttctgt tcgatcataa tatgcataga
    10381 accaagtaca cccctgatca gagatacaat gtcaaatctt tccatcaccg gggcatcttt
    10441 accggactcc agctgattca gcgtcagcag gtttttgacc agcttgttca tctttgaagc
    10501 ctcatccata ataacttcac agtaaaattc cctgctttcc ggatcatcgg aaatattttc
    10561 attcagcccc tctgcatatc cctggatcaa tgcaatagga gttttcagct catgagaaac
    10621 attatcaaga aattccttac gcatctcatc aattttaatc ttatcttcta tgtctttctg
    10681 aagcttgtta ttagccgatt tcaactctga gatcgtgctc tcaagttttc tggacatttt
    10741 gttaaagtta tcgccaagta catcaatctc attacctgcc ctgctttgat atctggcatc
    10801 aaaatccaga tcagacatct tctctgataa tttggtcagt tcactgattg ggcgggtaat
    10861 acgatttgtc atcacaagaa tcacaatacc gctgaccaca attatgatta ttcctacaat
    10921 gaagtaaaaa ctgttggaaa tagatgcact ttccttaata ctttccagag gagaacggat
    10981 caggaaatag taaccattat caaactgtcc ccagcattcc acatattcca tgcctgcaaa
    11041 gcgatcatgc acctgccaca tggtacaggt atctgtcttt ttgagcacac gactgtgctg
    11101 catatcctga tccagattat taatataccc aaacagctta ctgcggagca tttttgccat
    11161 attattctct ccccagtaat aataaccgct gttttcctca tttactatga tccaggtaag
    11221 gttatttctg gaactgctcc tctcaatctc atccgaaatc tcatctgttg cccctttttt
    11281 gtcctcttct atatctgtat catactgcag gatgtcatcc agattcatct gagacaacac
    11341 ttcttttgcc tcctccagca cttctacttt tttggataca taatattttt caagaaaaag
    11401 accattgatc agagtaatgg taaagatcga aagcagtaac agacatataa acactactga
    11461 aatctgatgt tgcagagtat gaaatttttt atctgttttt ccgtttcctg tcattcgtct
    11521 acctcaaact tgtatcccat accccataca gtctttatat attcaccttt atctcccatt
    11581 ttacttctga gcttcttaac atgggtatca atcgtacggg catctccaaa gtagtcataa
    11641 ttccatacag aattcaggat cttttctctg gaaagtgcga ttccctgatt ctccagaaaa
    11701 tatgtcagaa gttcaaattc cttaaagctc agttccatag gcttaccatc cacagtagcc
    11761 agatgtgctg ctttatctat aacaatgccg cctgctgaaa ttacatcttc aggattattc
    11821 tgacctgtac gtctcagaat tgcctccact cttgcaacaa ggattttcgg actgaatggt
    11881 ttagagatgt attcatctac gcccagatca aatccaagaa gctcatctct ctcatcactt
    11941 cttgcagtca gcataatgat cggaactttt gagttcttgc gaatctcacg gcaaacttcc
    12001 catccatcca tcttcggcat catgacgtcc agaatgatca gtgcgatgtc cttctcctca
    12061 taaaagatat ccatggcttc ttcaccatta ccggcttcca gtacctggaa attcttcttt
    12121 gtcaagaaat cctttaccag ctttctcatg cggctctcat catccaccac caggattttt
    12181 aatgtatcca tttgatcccc tccgtttttc ttcattattt tccgaaacag tttttacttt
    12241 ttatttatac tgttttccga gtattgttaa aatccacgac tgttcagcgc ctttacagcc
    12301 acagcgcaaa atccgggaaa atcgccctca gcaacagatt ttatctttca tatggttact
    12361 atagcagaga tttatgtaag atttgtgaac atatgacaga aaaattataa gtattgctgt
    12421 tcacaacacc aaatagcctt aaatataaaa atcttcttga caaattctgt ttttatttct
    12481 atactgttaa tcagtcgata tatcttatat aatgaatgat atatcaatat taaaaagtgc
    12541 tttcgtctca tcaccagtgc tgttttatga aaaaacagcg ttgcagactc attttcaggg
    12601 cttgtactgg tttcgacggg ggctttgaag ttggggaagc catccgcaga ctcccagact
    12661 gcgtaccaac cgggaaacta aatataaacg cagacgaaca gtacgcgtta gcagcctaat
    12721 tgctgctcgt cagccctgat gcactcacac ttcaggaatc tgacgtcgac catgtgagaa
    12781 accttgccgg gtaagctttg ccccggtaga tgtatcatga agctactaag gttgtaagcc
    12841 tgtcggtggg cgtacatcca agggaatgtt aaaacagcga ctgtgatggg agatgcctca
    12901 atgaataggc tttcggacgc gggttcaatt cccgccaggt ccataaaaaa catccacagg
    12961 gtaattccct gtggatgttt tttattcacc aaactgttgt gcacattctt tcagcatttc
    13021 gcggattggc agatggtacg gacatctggt ttcacatttg ccgcattcta tacaggcgga
    13081 agccttcacc gcaagagaac tgtaacggtt tcttgcccag tctcccagcc cgtaacggtt
    13141 aagatagcct gcgaacagga acacacccga aatatcgatt cccacactgc atggagcaca
    13201 gtaattacat ctgcggcaga aatttgtgcc aagctgattc cgtactgtct gaacttcctc
    13261 cagttctttc tcgcttaacg gggaatcatc aagacaggcc tttatattct cctcgatttc
    13321 cttctcttcc gccattcccg ggatcacaat agtaacgttc ttattcgaac agacataacg
    13381 caatgccagc gttccatttt caattgcacc accggccaga ggtttcatat caataaagcc
    13441 gatgtttttc tcctcacatt ttgagatcag ctcttccccc tgactctcta caatattata
    13501 tggaaacata atagtttcca cccagtcaag ctccagagcc cgggcaaaaa cctcaacaga
    13561 atgagcggtc agaccaatat gtccgatttt tcctgctgct cttgcctcct gcagtgcttc
    13621 aagggcacca ccggccgcct gcacctgatc aagctgttcc atactcggat tatgcacctg
    13681 gtataattca atatgatctg tacgaagatt atgaagactc ttctcaatat cttcagccat
    13741 ggcttccttt gtacgtgcca tggactttgt ggcaattata aatctgtccc tgataccttc
    13801 cagtgcatat cccagatatt cttcactgac cgtatatcct ctggctgtat caatataatt
    13861 tactccccgg tctgccagct tatgcagcag tgtctttgtt ccttccgcat caattttctg
    13921 gatcggtatc ccgccaaggc ccattctgga aaccctgaga ccggtttttc caagtgttac
    13981 atattccata tttttttctc ctattttcaa tcagagataa aaaactgcca ccggatctta
    14041 ccgatggcag tttttatctc tttacatctg t
//
