LOCUS       gnlProkkaNNNDLDEC_4    14943 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NNNDLDEC_4.
ACCESSION   gnlProkkaNNNDLDEC_4
VERSION     gnlProkkaNNNDLDEC_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:38:01
            Original ID  :: gnl|Prokka|NNNDLDEC_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 39020
            Orig. end    :: 53963
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14943
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10264]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10264
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14943
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14943
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             296..1312
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_35"
                     /sec_met_domain="PF04055 (E-value: 2.4e-25, bitscore: 81.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDELTEFVTENGFPKFRAKQIYDWLYKNVTDFDNMRNIPADLK
                     AFLKSSSYISVANIEKKLVSRYDKTVKYLFSFNDGECVESVVMSYKHGYSICISTQVGC
                     KMGCTFCATGKSGFSRSLAPSEMLGQIEAAQRDLNIRISNIVLMGMGEPLDNFDNVVKF
                     LRLVSSDNGLNIGMRHITLSTCGIVPKIYELAKLHLGITLSVSLHAPNDEIRQRTMPIA
                     RKYSIEELLKACSDYFKTTGRRVTFEYSMISGVNDSDENARELAKRLEGTQSHVNLIPV
                     NTVEGTGYLKSNIKRQQTFINILAAKNIGATVRRTLGSDINASCGQLKRKHIEEGGK"
     CDS             1314..2039
                     /locus_tag="ctg4_36"
                     /transl_table=11
                     /translation="MEVFSKSDIGLVRNQNQDDCRFGVISPSCVWAVVCDGMGGANGGN
                     IASATAVDYISTKITDLYKDDMTKEQIGELMAEIVVNANMKVFEMSMKDPELTGMGTTC
                     EFVFVKDTTVHVVHVGDSRTYAIRGGKIKQLTEDHSVVQEMVRRGELTYEQAQNHPNKN
                     FITRALGIKPSVRLDYIEANFIYGDVLLICTDGLSNCVTTGDMVKICHENRGEGLITKL
                     VDKAKDGGGSDNITATVIY"
     CDS             2058..4163
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 259.2;
                     E-value: 6.9e-79)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_37"
                     /sec_met_domain="Pkinase (E-value: 4.1e-61, bitscore:
                     198.2, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKYLGKRLDGRYEIHELIGVGGMANVYRCTDTVDDREVAVKILK
                     DEYLNNEEFIRRFKNESKAIAMLSHPNIVKVYDVSFGDMIQYIVMEYIDGITLKEYIDQ
                     QGIIEWKDAIHLTAQILKALQHAHECGIVHRDIKPQNIMLLQDGTIKVTDFGIARFSDK
                     STRTMTEQAIGSVHYIAPEQARGDATDGKTDIYSVGVMLYEMLTGKLPFDGDSAVTIAL
                     MQLQSTPKHPREINPGIPIGLEQITMKAMEKLPSDRYTSAAEMLSDIERFRLNPSIVFD
                     YGNKSFVDNQPTKFVHSLRNSGVRNKIDNEATKVVDMPQDDVVVKEEQFADEDFVKEHK
                     PSYYAVKGIVIAAVAVCAIFFALAMFRGCSTSQAKDVEVPDYVGKSFVSIKENNPNDFK
                     FEVKSEYDESKEMGVILDQEPKGGSMKVKSGSTITVTVNGTDTEVSVPYVTNYSEKEAS
                     QALKEKNLIPEIVYVENTKTPKGYTIECFPKAGVKTTIGSTVYVYIASGERTKQVTLPS
                     VDGLMLSEAKQSLVDLGLTVETVQDDESKEPKDTVLGMSPLQYGKVDAGSVVTLTVSSG
                     LGDENTVNIFVDLPSDVEDSVDMTVIVDGAVDSRNSKTLVPKYNKTYTLELKGSGTSTV
                     VIQLDGQAYREYSVDFASAAVTTTASHDYVRATTAPPETEPSTQYYTDPYVAPDTTVQP
                     VTDDPEL"
     CDS             4198..5061
                     /locus_tag="ctg4_38"
                     /transl_table=11
                     /translation="MKSIGGFYYVRADGEDYECKARGSFRKSGNSPVAGDRVNISVPND
                     GFCAIEEILPRKNKLRRPALANLDILLLVCSTVEPLPNFTIIDKMTAAAVNNNMDPVIV
                     VTKNDLENGDKIADIYRHAGFEVFLCSEDDSSQTEELKSYLSGKVSAFIGNSGVGKSTL
                     LNKLFPSLSLETGQTSKKLGRGRHTTRVVELFELDGCFVADTPGFSTVDLQRYEMIDKG
                     RLQYCFPEFEKYLGECMFTSCSHTCEKGCRILEALSDGEIEETRHRSYVQMYNEVKDIK
                     SWQIKE"
     CDS             5043..5693
                     /locus_tag="ctg4_39"
                     /transl_table=11
                     /translation="MADKGVIMRCVIIAGSPDTNSDFLSEVIKPDDYVICADRGCNFAK
                     QAGITPNLVVGDFDSEPDVLFPNCETVRLIPEKDDTDTMHSVDLALEKRFDEIAILGAL
                     GGRFDHSFANVAVLSYIHEHGSKGVLLSEKEKIEFLPVGHYEYKNFKGKIFSLFPFGCP
                     SVCVSYSGTKYPLEKYCVSSSVTLGVSNVFTSDMTTIDIYDGNAILIINLIDC"
     CDS             6003..7640
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 81.3;
                     E-value: 1.4e-24)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_40"
                     /sec_met_domain="Pkinase (E-value: 1.3e-13, bitscore: 42.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLCMGCMQEIGDNKICPSCGFDTTEKQQAPFLPYGTILQNRYIV
                     GAGIDTNGESTRYISHDKQTGDIVIICEFLPIGLFSREEGTTEVRINYENRLVYNKLKD
                     DFLNYYRILSELRELSALMNVHNIFEENNTVYVVEENEDLIPFEEYVERSNGHLEWDIA
                     RPLFMPVISALEALHKRGVGHYAIAPKNMYITASGKIKISGFASENERKRGTPLKSQLF
                     SGAAAPEQYDDNFPLDDITDIYGFCATLFYALTGHMPKSAVERRKDSRLLMSTTTVKRL
                     PPHVVSALANGLQVERENRITDFDELRSQLSVAHTAKAIQDEISRTASMNLTKSERTRK
                     TSNGMSHASIIIIAAAITVLVLGIAGVFWLMQNPLAGMFSNNTDASVSSTQNTEWTGAT
                     VPNYIGMTYEEAVKSVDSNSSITIYRTFNDEYSDDYAEGKIMSQTPAAGSKITQEDSVV
                     VSVCVSKGSQMRTLPKVEGEKLDTVASDIAAQGLLATAEYEYSDKVAEGRVIRYKEHVE
                     GDTLEYGSTVVLIVSKGKKQTSSQSSNR"
     CDS             7904..8188
                     /locus_tag="ctg4_41"
                     /transl_table=11
                     /translation="MTIKPLLDRVVLKVEEAEEKTKSGIILSSAAQEKPQFASVVAVGP
                     GGVVDGKEVKMYVSVGDKVIASKYAGTQVKIDGEEYTIVNQSDILATLE"
     CDS             8217..9845
                     /gene_functions="other (smcogs) SMCOG1299:chaperonin GroEL
                     (Score: 813.3; E-value: 1.2e-246)"
                     /gene_kind="other"
                     /locus_tag="ctg4_42"
                     /transl_table=11
                     /translation="MAKQIAYGEDARKALMKGIDQLADTVKITLGPKGRNVVLDKKFGA
                     PLITNDGVTIAKEIELEDPFENMGAQLVKEVSIKTNDIAGDGTTTATLLAQALIREGMK
                     NVTAGANPMVLKKGIADAVNVAVEAVKKNSKQVSGTDDIARVATVSSQDEFIGKLIAEA
                     MEKVTTDGVITVEESKTAETYSEVVEGMMFDRGYIAPYMVTDTDKMVAELDNPLILITD
                     KKISTTQEILPLLEQIVQMGKKLLIIAEDVEGEALTTLVLNKLRGTFTCVAVKAPGFGD
                     RRKEMLQDIATLTGGTVITSDLGLELKDTTVDQLGTARQVKIEKENTIIVDGSGDKEAI
                     KGRVAQIRQQIETTTSDFDREKLQERLAKLAGGVAVIKVGAATEVEMKEKKLRIEDALA
                     ATKAAVEEGIVAGGGIACMNAIPAVAEFVDTLEGDAKTGAKIVLKALEEPLRQIVANAG
                     LEGSVICDNVKKANKVGYGFNALTEEYTDMVSAGIVDPTKVTRSALQNASSVAAMVLTT
                     ESLVTDIKEPAVPAAPAAPDMGGMY"
     CDS             10001..10264
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_43"
                     /sec_met_domain="PF05402 (E-value: 3.6e-17, bitscore: 54.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.3e-13,
                     bitscore: 42.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKEDFVLRKVADSYVVVPVNKLTLDFNGIINLNETGAFLFEKL
                     QNDCEKADLLKAMLDEYEVSEEKASADIDTFIQKLREADVLE"
     CDS             10251..10739
                     /locus_tag="ctg4_44"
                     /transl_table=11
                     /translation="MSLNKEVGLDDVMQIIAEKLETGGSVTFNPKGTSMLPMLRDGDDT
                     VVLSKPKGRLHLFDLPLYRRKDGSYVLHRVVNFGSDGSYTMCGDNQFAVEKGITDDDVI
                     GVVTAFYRKGKPYTVDSMKYRAYLEFMFYSKPLRKVIASTMSRSKNAFSKLKTKKGKK"
     CDS             10736..11638
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_45"
                     /sec_met_domain="NTP_transf_5 (E-value: 1e-37, bitscore:
                     121.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKHLNDNEKIEFKYLLELVSSSVNGTAPPIPYEGIKWQSIKMLA
                     NYCSVESLVANAVLSLDKKYVSPEVYEKFKQNLSVEMLIDGNLSYETEKILKAFDENKI
                     KNIPLKGYFMKKEYPRSDFRSVSDVDILFDRKQADSVKKVFSKLGYTFLNEDDNQYHFE
                     KKPMMNIEMHATLVHENEESYPLLVNQLDRSTKRDGYSYSYEMSHEDFYIYMLVHNSNH
                     FRIGGMGARMVLDSYVFLKNHQSELDYDYLNVMLEKSVLQSMKSVCVRLRSTGFQSHRL
                     NLNLMISKNIFCSAVHSAG"
     CDS             11737..11955
                     /locus_tag="ctg4_46"
                     /transl_table=11
                     /translation="MQYKYPYVKKTPFLLPISWCHMWGKRLFVDRNINFKSGIKNRMSY
                     TDEDVNLYKSLLDEMGFDGIGINNFGN"
     CDS             12061..12927
                     /locus_tag="ctg4_47"
                     /transl_table=11
                     /translation="MVRIITDSAADFEHSESEKFGISTIPLAVYIDGKEYKDDFLHSKE
                     RFYRLAKLSKTLPKTSQPSPYVYECSLKKARDNGESVVVITVSSALSGSYQSAVLARDL
                     LGYEGCYVIDSKSASAGQKLLVNEALRLRDNGFTAKEIAEHLLRFRSKIMVYACIDDMK
                     YLYGGGRHTNAAALLGSTGRIKPVISITGSGSVAFEAKTIGMRHGMNHMLMSLKKLGID
                     QNYPLYIMHTNAKNQALYLSKLIISKGIPFVEGSIVSVGSVVGSHIGEGSTGIAFVKKE
                     QRKSGHD"
     CDS             complement(12949..13233)
                     /locus_tag="ctg4_48"
                     /transl_table=11
                     /translation="MQILFIAFAAGIYFLFINRKTNIETVLLPLVILGAFGYHLLFEGK
                     SQYVLTYIILMIPTASFAFECILNGKYTKIKEFVGKLKEIPDGKESEKA"
     CDS             complement(13253..14632)
                     /locus_tag="ctg4_49"
                     /transl_table=11
                     /translation="MGNTKTKNNSNKPKQTGKTVTSVKKQNTVEYVIVNILCLFVFIAF
                     AYIAIMSFVQTSVFDSANYGSEVILYQTDNIALNILFTSLFTVFIFKMKKHCDFFAKVN
                     LKYMHIGLAAFVMIVGLVWIFSVTSVPAADSYNIYETASQAAKGNYSSFNNNSGFYNSD
                     FYSGYSYYNFYPFQLGFVFISEIFYRIFGTDSTMPIQVFNVMCTAAAYIGIVNITRLLF
                     KKRSVEFITILLLAGCFQPVLFCTFVYGNIIGMCFAIWASYFLIKYFQTNKYLLLIPCA
                     VLLVISTLAKYNNLIYLVAFVVMLVIHTIKAKKWQSIAFALAICIVVVGTSNLVIMSYE
                     NRSGVKLSSGVSQAMYLDMGINDSYMAPGWYNGIALNDYKSAGLDAKAANAQAWTNIKS
                     RMNYFGKNTNYMIDFFSKKIISQWNEPTYESIWVSKVKSHTNELNWIGNGMYDGSIGQF
                     L"
     CDS             complement(14650..14943)
                     /locus_tag="ctg4_50"
                     /transl_table=11
                     /translation="MGGNEMSAYGLCHLGDYEATLFSKWSHNRMYGESFAKGDRFTKLA
                     EGVMTSKALYKLGQEYGVDLPIVESVYKVLFDGTDIKEALGTLFMRSVKKEF"
ORIGIN
        1 tgcagtacag gattctctgt gcaagtgcgg ataatctggc agtaggcggt aagcttgtct
       61 attctacctg tacattgaat cctgatgaaa acaataaaaa cacaaagcgt tttcttgagg
      121 aacatcccga tttttacggt ataccgttaa aacttccaaa cggaattacc cgtgcatttg
      181 atgaagaacc atacgaaata acacttatgc cgcacacttg cggaacagac ggattttaca
      241 tcagcttatt cggaaagaag gcgtcaaatt gaataattta acggatatca agtcaatgac
      301 gcttgatgag ctgactgaat ttgtcacaga aaacggtttt ccaaagttca gagcaaagca
      361 gatttatgat tggttgtaca aaaatgtgac cgattttgac aatatgcgta acattcctgc
      421 cgatttaaag gcttttttga aatcaagtag ttacatttct gttgcaaata ttgaaaaaaa
      481 acttgtttca aggtatgata aaacagtcaa gtaccttttt tcgtttaatg acggcgaatg
      541 tgtagagtct gttgtaatga gttacaagca cggatattca atctgtattt caacacaggt
      601 tggttgtaaa atgggttgta cattttgtgc aacaggcaaa agcggttttt cacggagtct
      661 tgcaccgtcg gaaatgctcg gacagattga ggccgcacag cgtgatctta acataagaat
      721 ttctaacatt gttcttatgg gaatgggtga accgcttgat aattttgata atgtcgtaaa
      781 atttctccga cttgtttcgt ccgacaatgg tcttaacatt ggaatgcgac atattacgct
      841 ctcaacctgc ggtatagttc cgaaaattta tgagcttgca aaacttcatc tcggaataac
      901 gctttccgtt tcattacacg cgccgaacga tgagataaga cagcgaacaa tgcccattgc
      961 aagaaaatat tctattgaag aattattaaa ggcttgttca gattatttca aaacaacagg
     1021 tcgcagagtt acatttgaat actctatgat aagcggagtt aatgacagcg atgaaaacgc
     1081 aagagagctt gcaaaacgac ttgaaggtac acaaagccat gttaatctga ttcccgtcaa
     1141 tacagttgag ggaacaggct acttaaaaag caatattaaa agacagcaga cattcataaa
     1201 tattcttgct gctaaaaata tcggagcaac cgtgcgcaga acactcggaa gtgacataaa
     1261 cgcatcgtgc ggtcagctca aaagaaagca tattgaagaa ggaggtaaat aacttggaag
     1321 tattcagcaa aagtgatatc ggacttgttc gtaatcagaa tcaggatgac tgtcgcttcg
     1381 gagttatttc tcccagctgt gtctgggcag ttgtgtgtga cggaatgggc ggtgcaaacg
     1441 gcggtaatat tgccagcgca acggcagttg attatatcag caccaaaatt accgatttgt
     1501 acaaagatga tatgaccaag gagcagattg gcgagcttat ggcagaaatt gttgtcaatg
     1561 ccaatatgaa agtctttgaa atgtccatga aagatcccga gctcacgggt atgggaacta
     1621 catgtgaatt tgtctttgta aaagatacaa ccgttcatgt tgttcatgtc ggtgacagtc
     1681 gcacatacgc tatcagaggc ggtaaaatca agcagcttac agaggatcat tccgttgttc
     1741 aggaaatggt tcgaagaggc gagcttacat atgagcaggc gcaaaatcat ccgaacaaga
     1801 actttataac aagggcgctc ggcataaaac cgtccgttcg ccttgactat attgaagcca
     1861 actttattta cggtgatgtt cttctcatct gtaccgacgg actttcaaat tgcgtcacaa
     1921 caggagatat ggtcaaaatc tgccatgaaa accgtggcga aggtcttatc acaaagcttg
     1981 ttgacaaggc gaaagacggc ggaggttctg ataatatcac agctaccgta atttactaag
     2041 gataggagtt gaccgttttg gataaatatt tgggcaaaag acttgacgga agatatgaaa
     2101 tccacgagct tatcggtgtc ggcggtatgg caaatgttta ccgttgtacc gacacagtcg
     2161 atgaccgtga agttgccgta aaaattctta aagacgagta tctcaacaat gaggagttta
     2221 tccgccgttt caaaaatgaa tcaaaagcca tcgcaatgct ttcacatccg aatattgtaa
     2281 aggtgtatga tgtaagtttt ggcgatatga ttcagtatat cgtaatggaa tatattgacg
     2341 gcattaccct caaagaatat attgatcagc aaggtattat tgagtggaaa gacgcaatcc
     2401 acctgaccgc acagatttta aaggctttac agcacgctca cgagtgcgga attgtacacc
     2461 gtgatataaa gccgcaaaat attatgctgt tgcaggacgg tacaatcaaa gttaccgatt
     2521 tcggtattgc aagattttcc gataaatcga cacgcacaat gacggaacag gcaatcggct
     2581 ctgttcacta cattgcccct gagcaggcaa gaggtgacgc aactgacgga aaaacggaca
     2641 tttattctgt cggtgtaatg ctctatgaaa tgcttacggg aaagcttccg tttgacggtg
     2701 acagtgccgt tacaattgcg cttatgcagt tgcagtcaac accgaagcat cctcgtgaaa
     2761 tcaatccggg aatcccgata ggtcttgagc agattactat gaaggcaatg gaaaagcttc
     2821 cgtccgacag atacacttct gccgcagaaa tgctttctga tatcgaaaga ttcagactta
     2881 atccgtcaat cgtttttgat tacggcaaca agtcttttgt tgataatcag cccacaaagt
     2941 ttgttcactc tctgcgtaac agcggggtaa gaaataaaat tgacaacgag gcaaccaaag
     3001 tagttgatat gccgcaggac gatgttgttg ttaaagaaga acagtttgcc gatgaggatt
     3061 ttgtaaagga gcataagccg tcatactatg cagtcaaggg tattgtaatt gcggctgttg
     3121 cagtgtgtgc aattttcttt gcacttgcaa tgttcagagg ctgctcaacc tcacaggcta
     3181 aggatgttga agttcccgat tatgtcggca aatcctttgt ttcaataaaa gaaaataacc
     3241 cgaatgattt taagtttgag gttaagagtg aatatgatga gtcaaaggaa atgggcgtaa
     3301 ttcttgatca agagcctaag ggcggttcaa tgaaggttaa gtcaggctca acaatcacgg
     3361 taactgtaaa cggaacggac acagaggttt ctgttcctta tgtaaccaat tacagcgaaa
     3421 aagaggcttc tcaggctctc aaggaaaaga atcttattcc tgaaattgtc tatgtagaaa
     3481 acactaaaac accaaagggc tacacaattg agtgcttccc gaaagcaggt gtaaaaacta
     3541 caattggttc aacggtatat gtatatattg caagcggtga gagaaccaaa caggttacac
     3601 tcccgtcggt tgacggactt atgctttccg aagcaaagca gtctcttgtt gatctcggac
     3661 ttaccgttga aacagttcag gatgatgaaa gcaaagaacc aaaggataca gtcctcggta
     3721 tgtcgcctct ccagtacggc aaggttgacg caggctctgt tgtaaccctg actgtaagct
     3781 cgggactcgg tgacgaaaac acagttaata tcttcgttga ccttccgtcg gatgttgaag
     3841 attcagtcga tatgactgta attgttgacg gtgcagttga ttcccgtaat tcaaagacac
     3901 ttgttccgaa atataacaag acctatactc ttgagctcaa gggctcaggc acttcaactg
     3961 tagtaattca gcttgacggt caggcgtaca gagagtattc ggttgacttt gcatcggcag
     4021 cggtaaccac tacggcgtca catgattatg tccgtgcgac aaccgctcct cccgaaaccg
     4081 aaccttcgac acagtattac acagatccgt atgtagcgcc tgacacgacc gttcagccgg
     4141 ttacggatga tcctgaactt taatcggtga agtatggata ctaaaagcgg aattttaatg
     4201 aaatcaatcg gcggatttta ctatgtccgt gccgatggcg aggattacga atgtaaggca
     4261 agggggagtt ttcgcaaaag cggaaactct cccgtagcgg gagacagggt aaatatatct
     4321 gttccgaatg acggcttttg tgcgatagaa gaaattcttc cacgcaaaaa caagctccgc
     4381 agacctgctc ttgcaaatct tgatattctt cttctcgtgt gttcaactgt tgaaccgttg
     4441 ccgaatttta cgattattga caaaatgact gcggcggcgg taaacaataa tatggatccc
     4501 gtaattgtcg ttacaaaaaa tgatttggaa aacggagata agattgccga tatctacaga
     4561 cacgcaggtt ttgaggtttt tctctgttcg gaagatgatt cttcacaaac cgaagaactc
     4621 aaaagctatc tgtccggcaa ggtttcagcc tttatcggta acagcggcgt cggcaagtcc
     4681 acattgctca ataagctttt tccatcgctt tctcttgaaa cagggcagac aagtaaaaaa
     4741 ctcggcagag gaagacatac aacaagagtt gttgaactgt ttgaacttga cggttgtttt
     4801 gttgcagaca cacccggatt ttcaaccgtc gatcttcagc gttacgaaat gattgacaaa
     4861 ggccggctgc aatattgctt tcctgaattt gaaaaatatt taggggagtg tatgtttact
     4921 tcatgttcgc atacctgtga aaaaggctgc aggattcttg aggcgctctc tgacggtgaa
     4981 attgaagaaa cccgtcaccg cagttatgtt cagatgtata acgaggtcaa ggacattaaa
     5041 tcatggcaga taaaggagta attatgcgtt gtgtgattat tgcaggctcg cctgacacaa
     5101 attcggattt tttgtccgag gttataaaac ctgatgacta tgtgatatgt gccgacagag
     5161 gttgcaattt tgcaaaacag gcaggcatta ctccgaacct tgttgtagga gattttgatt
     5221 ccgagcctga tgtactgttt ccaaactgcg aaacggtccg acttattccc gaaaaggatg
     5281 ataccgacac aatgcactct gttgaccttg cacttgaaaa aaggtttgac gaaatagcaa
     5341 ttctcggtgc attgggcggt cgctttgacc acagctttgc aaatgtggct gttctctctt
     5401 atattcacga acacggaagc aagggcgttc tcctttctga aaaagagaaa atagaatttc
     5461 ttcccgtagg tcattatgaa tataaaaact ttaaaggcaa aatattttcg cttttccctt
     5521 tcggatgtcc gagtgtctgc gtaagctatt cgggaacaaa gtatcctctt gaaaaatact
     5581 gtgtttcgag cagcgttact ctgggtgttt caaatgtatt cacttcagat atgacaacaa
     5641 ttgacatata tgacggaaat gcaatactta taattaattt gatagactgt taaaattaca
     5701 gcttgacatt gtttgcaaat gtatcttgta tatgtcaaaa gcaatgtcaa cattatatgg
     5761 gggtatagct cagctgggag agtgtctgac tggcagtcag aaggtcacgg gttcgagccc
     5821 cgttatctcc accacatttt ttatacaaca atatttgcaa agaatttgct ttgtaaggct
     5881 ttgcaataac aaaattgtaa ctatattaac acctttaagt cttgaaaaga aatatgtttt
     5941 tatggtataa ttcttttcag acaaaatttg aaattgatac ttatttggag ttgagtaata
     6001 atatgtcatt gtgtatggga tgcatgcagg aaataggtga caacaagatt tgtccgtcct
     6061 gcggatttga tacaactgaa aaacagcaag ctcctttttt accgtacgga acaattcttc
     6121 agaaccgtta tatcgtaggt gcgggaattg ataccaacgg cgaaagcaca cgctatataa
     6181 gccacgacaa gcagacaggt gacattgtaa tcatctgcga atttcttcct atcggacttt
     6241 tttctcgtga agaaggaact accgaggtca gaataaatta tgaaaaccgc cttgtatata
     6301 ataaactcaa ggacgatttt cttaactatt acaggattct ttcagaactc cgtgagcttt
     6361 ccgctcttat gaatgttcac aacatttttg aagaaaataa cacagtttat gttgttgagg
     6421 aaaacgagga tcttattcct tttgaggagt atgttgaacg cagtaacggt catcttgaat
     6481 gggatattgc ccgtccgctt tttatgcctg taatttctgc tcttgaggct cttcacaaga
     6541 gaggtgtcgg tcactatgct atcgcaccta agaatatgta tatcacagca tcgggtaaaa
     6601 ttaagatttc aggctttgcg tcggaaaatg agcgtaaaag aggcacgcct ctcaaatctc
     6661 agcttttttc aggcgctgcg gctcccgaac agtatgatga taattttcct cttgacgata
     6721 ttacggatat ctacggattt tgtgcaaccc ttttctatgc cctcacaggt catatgccaa
     6781 agagtgcggt agaacgccgt aaggacagcc gacttcttat gagtacaaca accgtaaaga
     6841 gacttcctcc gcatgttgtt tcggctcttg ctaacggttt gcaggttgag cgtgaaaacc
     6901 gtattacaga ttttgacgag cttcgttcac agctttccgt tgctcataca gcaaaggcaa
     6961 ttcaggacga aatttcaaga acagcaagca tgaacctcac aaagtcagag cgtacacgca
     7021 agacttcaaa cggtatgtca cacgcttcaa ttattattat tgcggctgct atcacggttc
     7081 ttgttctcgg tattgccggt gtgttctggc ttatgcagaa tccgcttgcc ggaatgttct
     7141 caaataatac tgatgcgagt gtaagctcaa ctcaaaacac agagtggaca ggtgctactg
     7201 ttcctaacta tatcggaatg acatatgaag aggctgttaa gagtgttgac agcaacagca
     7261 gtatcacaat ctacagaact tttaacgatg agtacagcga tgattatgca gaaggtaaga
     7321 ttatgtcaca gactcctgcc gcaggttcaa aaatcactca ggaagattcc gtagtagtga
     7381 gtgtttgcgt aagcaaggga tcacagatga ggactctgcc gaaggttgag ggtgaaaaac
     7441 ttgataccgt tgcatccgac attgccgctc agggacttct tgcaacagcg gaatatgagt
     7501 acagtgacaa ggttgctgag ggaagggtaa tccgctacaa agaacatgtt gagggtgata
     7561 ctctcgaata cggttcaacg gtagttctta ttgtcagcaa gggcaagaaa cagacaagtt
     7621 ctcaatcatc aaacagataa aattaataac aatgtttaag acggactttt tgcagtccgt
     7681 cttttttgtt gatacaaaac agttatagtt actgattatc ttaaaatact cgataaattt
     7741 gagattggaa aaaatttcag aaaactgtca caaaataaag gtcaaaaata gtcaaatttc
     7801 tcttgacttt tcttgaaaat ggtataaaat ataattagca ctcagggaac aagagtgcta
     7861 attaattaaa agtaatttaa aatttttaca ggaggctgta tttatgacaa tcaaaccatt
     7921 actcgacaga gtcgttttaa aagttgaaga ggctgaagag aaaacaaaga gcggtatcat
     7981 tctttcatct gctgctcagg aaaagccaca gttcgcatca gttgttgctg ttggccccgg
     8041 cggtgttgtt gacggcaagg aagtaaagat gtatgtcagc gtaggcgata aggtaatcgc
     8101 aagtaaatat gcaggcacac aggtaaagat tgacggcgaa gaatacacaa tcgtaaacca
     8161 gtcggatata ctcgcaactc ttgaataatt aactaaatat acggaggtaa tttacaatgg
     8221 ctaaacaaat cgcatacggc gaagatgcaa gaaaagcttt aatgaaaggt atcgaccagc
     8281 tcgctgatac cgttaaaatc acactcggac ctaagggcag aaatgttgtt cttgataaga
     8341 agttcggtgc tccgctcatc acaaatgacg gtgtaacaat tgctaaggaa attgaacttg
     8401 aagatccttt tgaaaatatg ggtgctcagc ttgtaaagga agtttctatc aagactaacg
     8461 atattgcagg cgacggtaca acaactgcca cacttcttgc tcaggctctc atcagagagg
     8521 gtatgaagaa tgtaactgca ggcgctaacc caatggtact taaaaagggt attgcagacg
     8581 ctgtaaatgt tgcagttgag gctgtaaaga agaacagcaa gcaggtatcc ggtacagacg
     8641 atatcgcaag agttgcaaca gtttcatcac aggatgaatt catcggcaag cttattgccg
     8701 aggctatgga aaaggttaca acagacggtg ttatcacagt tgaggaatca aagacagccg
     8761 aaacatacag cgaggttgtt gaaggtatga tgttcgacag aggttacatc gctccttata
     8821 tggtaacaga tacagataag atggttgcag agcttgacaa tccgcttatc cttatcacag
     8881 ataagaagat ttctactaca caggaaattc tcccacttct tgagcagatt gttcagatgg
     8941 gtaagaagct ccttattatc gctgaagatg ttgaaggcga ggctcttaca actctcgtac
     9001 ttaacaaact cagaggtaca ttcacttgtg ttgccgtaaa ggctccgggc tttggtgaca
     9061 gaagaaaaga aatgcttcag gatatcgcaa cactcacagg cggtacggtt atcacatccg
     9121 acctcggtct tgaactcaag gatacaacag ttgatcagct cggtactgcc cgtcaggtta
     9181 agattgaaaa ggaaaacaca atcatcgttg acggctcagg tgacaaggaa gctatcaagg
     9241 gcagagttgc tcagatcaga cagcagattg aaacaacaac atctgacttt gaccgtgaaa
     9301 aacttcagga gcgtcttgca aagctcgcag gcggcgtagc agttatcaag gttggtgctg
     9361 caacagaagt tgaaatgaaa gaaaagaagc tccgtattga ggatgctctt gccgctacaa
     9421 aggctgctgt tgaagagggt atcgtagcag gcggcggtat cgcttgcatg aacgctattc
     9481 cggctgttgc tgagttcgtt gacactctcg agggtgacgc taagacaggt gctaagattg
     9541 ttcttaaagc acttgaagaa ccgctccgtc agattgttgc taacgcaggt cttgagggca
     9601 gcgtaatctg cgacaatgtt aagaaggcta acaaggttgg ctatggcttc aacgctctta
     9661 cagaggaata cacagatatg gtttcggcag gtatcgttga cccaacaaag gttactcgtt
     9721 cagctctcca gaacgcaagc tctgttgcag caatggttct tacaacagaa tcacttgtta
     9781 cagacatcaa agagcctgca gttccggcag ctcccgcagc acctgatatg ggcggaatgt
     9841 actaatcccg taaacttata atattataga taaattttac cgcagactca aaaggtctgc
     9901 ggtaatttta tgctcaaatc ctttttcttg ctttttgtcg aaaggtatat tataatttaa
     9961 atatgtacta aaaaatttca cactgaaaac aggtgatgtt atgaagataa aagaagattt
    10021 tgttctgcga aaggttgcag attcgtatgt tgtagttccc gtaaataagc tgacgcttga
    10081 ttttaacgga attatcaacc tcaatgaaac gggtgcattc ctttttgaaa agctccaaaa
    10141 cgattgcgaa aaggctgatt tgctcaaagc aatgcttgat gagtatgaag tgagcgaaga
    10201 aaaggcgagc gccgatattg atacatttat tcaaaagcta agagaggctg atgtccttga
    10261 ataaagaagt aggtcttgat gatgtaatgc agattatagc cgaaaagctt gagaccggag
    10321 gatcggttac tttcaatccg aagggaacaa gtatgctccc aatgctccga gacggtgacg
    10381 atacggttgt tttatcaaaa ccgaagggca gacttcatct ttttgacttg cctttataca
    10441 gacgaaaaga cggctcgtat gtattgcacc gtgtcgtcaa tttcggaagt gacggcagtt
    10501 atactatgtg cggtgacaat cagtttgccg ttgaaaaagg tattaccgat gatgatgtaa
    10561 tcggagtggt aacagccttt tacagaaagg gcaagcccta cacggttgac tcaatgaagt
    10621 acagagcata ccttgaattt atgttctatt caaaaccgct aaggaaggtt attgcatcaa
    10681 ctatgtcaag aagtaaaaat gcattctcaa agcttaaaac gaaaaaaggg aaaaaatgag
    10741 gaaacatctt aacgataacg aaaaaattga atttaagtat ctacttgagc ttgtttcatc
    10801 gtctgtaaac ggaacagcac ctccgattcc ttatgagggg ataaaatggc agtcgataaa
    10861 aatgcttgca aactattgca gtgttgaatc gcttgttgcc aatgcggttt tgtcgctcga
    10921 caaaaagtat gtttcgcccg aagtatatga aaaattcaag cagaatttgt cggttgaaat
    10981 gctgattgac ggaaatctct catatgaaac cgagaaaatt ctcaaggctt ttgatgaaaa
    11041 caaaattaag aatattccct taaagggcta ttttatgaaa aaggaatatc ctcgttccga
    11101 ctttcgttcc gtgtccgatg tagatatcct ttttgacaga aaacaggctg attcggtcaa
    11161 aaaagtattt tcaaaactcg gatacacttt tctgaatgaa gatgacaacc agtatcattt
    11221 tgaaaaaaaa ccgatgatga acattgaaat gcatgcaact cttgtccacg aaaatgagga
    11281 atcttatccg ttgcttgtta atcagcttga ccgttcaaca aagcgtgacg gctacagcta
    11341 ttcatatgaa atgagccatg aggactttta tatctatatg cttgttcata actcgaatca
    11401 tttcagaatc ggcggaatgg gagcaagaat ggtgcttgac agctacgttt tcttgaaaaa
    11461 tcatcaatct gagcttgatt atgactatct taatgtgatg cttgaaaaat cggtattgca
    11521 aagtatgaaa agcgtgtgcg tgagattgcg ttcaactggt tttcaaagcc acaggctgaa
    11581 cttaaatttg atgatatcga agaatatatt ctgctcagcg gtacactcgg cagggtagat
    11641 gtcggcacga tgataaattc ccacaagaca attaccgaga ataacaaatc aaaattttca
    11701 taccttgtat cctcaatatt tccgccaaaa tccgaaatgc agtataagta tccatatgta
    11761 aaaaaaacac cgttcctttt accgatttca tggtgtcata tgtggggaaa aaggcttttt
    11821 gtagacagaa atatcaattt taaatcgggt atcaaaaacc gtatgtcata cacggatgaa
    11881 gatgtaaatt tgtacaagtc ccttttggat gaaatgggct ttgacggtat tggaataaat
    11941 aatttcggaa attgaatatg caaatcaacc tcccgacagt ttttgctgtc gggatttttg
    12001 cataataaag gtaaatttga aaataatatt tcaagatatt atttttgagg tgatacctaa
    12061 atggtcagaa ttattaccga ttcagccgcc gattttgaac attcagaaag tgaaaaattc
    12121 ggaatttcta caattccgtt agctgtgtat attgacggaa aagaatataa ggatgatttt
    12181 ttacattcaa aggaacgctt ttacaggctt gcaaagctgt cgaagacttt gccgaaaacc
    12241 tctcaaccct cgccgtatgt ctacgaatgt tctttgaaaa aggcgagaga taacggcgaa
    12301 tcggttgtgg tgataactgt ttcttcggca ttgagcggtt catatcagag tgcagttctt
    12361 gcaagagatt tgctcggata tgaggggtgt tatgtgatag acagcaaatc tgcttcggca
    12421 ggtcagaagc ttcttgtaaa cgaggcactt cgcctgcgtg acaacgggtt tacagcaaaa
    12481 gaaattgccg aacatcttct gaggttcaga agtaaaatta tggtatatgc ctgtattgac
    12541 gatatgaagt acctctatgg gggtggcaga catacaaatg ccgccgcatt actcggctca
    12601 acaggaagaa taaaacccgt aatcagcatt acgggttcgg gcagtgtagc ctttgaggcg
    12661 aaaacaatcg gaatgcgcca cggtatgaat catatgctga tgtcgttgaa aaagcttggc
    12721 atagaccaaa attatccgct gtatataatg cacacaaacg caaaaaatca ggcattgtat
    12781 ttatcaaagc tcataatatc aaaaggaatt ccttttgttg agggcagtat tgtcagcgta
    12841 ggttccgttg tcggcagtca tataggagag ggcagtacgg gtattgcatt tgtcaaaaaa
    12901 gagcaaagaa aaagcggaca tgattaactg tccgcttcaa tcattttatc aggctttttc
    12961 gctttcttta ccgtcgggaa tttctttaag ctttccgaca aattctttga tttttgtata
    13021 tttgccgtta agaatacact caaatgcaaa agacgcagta ggaatcataa gaattatgta
    13081 agtcagcaca tactgcgact tgccttcaaa taagaggtga tatccgaacg ctcccagaat
    13141 aacaagaggg agaagtacgg tttcaatatt tgtctttctg ttaatgaaca agaagtaaat
    13201 tcctgccgca aacgcaatga aaagaatctg catatagaag ttaaagtaca gttcaaagaa
    13261 actgtccgat actgccgtca tacattccgt tgccgatcca attaagctcg tttgtatgag
    13321 acttgacctt gctaacccat atgctttcgt atgtcggttc attccattgg ctgataattt
    13381 tcttcgagaa gaagtcaatc atatagtttg tgtttttacc gaagtaattc attcttgatt
    13441 ttatattggt ccaagcctgt gcatttgcgg cttttgcgtc aagacctgcg cttttataat
    13501 cgttgagggc aattccgttg taccaaccgg gagccatata tgaatcgtta atgcccatat
    13561 caaggtacat agcctgtgaa acaccgcttg aaagcttcac tcccgaacgg ttctcataac
    13621 tcatgataac aaggttgctt gttccgacaa caacaatgca aattgcaagt gcaaacgcaa
    13681 tgctctgcca ctttttagcc ttaattgtgt gaataaccag cataacaaca aacgcaacaa
    13741 gataaatcag gttgttgtat tttgcaagtg ttgaaataac gagaagtaca gcacacggaa
    13801 tgaggagcag gtacttgttt gtctgaaaat acttgatgag gaagtatgat gcccagattg
    13861 caaagcacat tccgatgatg ttgccgtaaa cgaatgtgca gaaaagtacg ggctgaaaac
    13921 agccggcaag cagaagaatt gtaataaatt caaccgaacg ctttttgaaa agaagtcttg
    13981 tgatgtttac aatacctata taagcggcag ctgtacacat tacattgaat acctgaatcg
    14041 gcattgtact gtccgtaccg aaaatcctgt aaaaaatttc gctgatgaaa acaaagccaa
    14101 gctggaacgg atagaagttg tagtaagaat atccgctgta aaaatcgctg ttgtaaaaac
    14161 cgctgttatt gttgaatgac gaatagttgc ccttagcagc ttgcgacgct gtttcataga
    14221 tgttgtagct gtcagccgcg ggaacagagg ttaccgagaa tatccagaca agtcccacaa
    14281 tcatgacgaa cgccgcaaga cctatatgca tatattttag attgaccttt gcaaaaaagt
    14341 cacaatgctt tttcattttg aatataaaaa cggtaaacag ggaagtgaac aggatgttca
    14401 gcgcaatgtt atccgtctga tacaaaatta cttcactgcc gtaatttgcc gaatcaaaca
    14461 cgcttgtctg cacaaagctc ataattgcta tgtatgcaaa tgctatgaat acaaacagac
    14521 aaagaatgtt tacaataaca tactcgactg tattctgctt tttaacagaa gtaaccgttt
    14581 ttccagtctg tttaggttta tttgaattgt tcttagtttt agtattaccc atattatgta
    14641 cctgcccgat taaaattctt tcttgacaga acgcataaac agagttccga gtgcctcttt
    14701 gatatctgtt ccgtcgaata aaaccttgta tacagactca acaatcggaa ggtcaacacc
    14761 atattcctga ccgagcttgt ataacgcttt tgatgtcata acaccctcgg caagctttgt
    14821 aaatctgtct ccctttgcaa agctttcacc gtacattctg ttgtgactcc attttgaaaa
    14881 caaggtagcc tcatagtcgc cgagatgaca aagaccgtaa gcactcatct cattgcctcc
    14941 gag
//
