LOCUS       c00003_gnlPro..        14263 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OGPDIKNH_3.
ACCESSION   c00003_gnlPro..
VERSION     c00003_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 01:34:42
            Original ID  :: gnl|Prokka|OGPDIKNH_3
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14263
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14263
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[21:4263]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      22..4263
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..14263
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14263
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(22..1233)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_1"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 3.3e-13,
                     bitscore: 44.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEAQLHRLPTPCYLLDEAQLCRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RTDEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWDAAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEKKFADLLPRM
                     KWLNFGGGHHITRPGYALATLENCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     RNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             complement(1233..2492)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_2"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 1.5e-43, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 6.8e-32,
                     bitscore: 105.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTATKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHNPALVD"
     CDS             complement(2532..3407)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_3"
                     /sec_met_domain="Arginase (E-value: 9.6e-76, bitscore:
                     250.0, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAIR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALADIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGRI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLDAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             complement(3407..3502)
                     /locus_tag="ctg3_4"
                     /transl_table=11
                     /translation="MRTRYYTTKLHIGAFYLPAFLEEMLREVEEH"
     CDS             complement(3505..4263)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_5"
                     /sec_met_domain="Spermine_synth (E-value: 7.2e-53,
                     bitscore: 173.9, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 1.1e-21,
                     bitscore: 71.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPGNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKNTIPLMIWTQKRGRR"
     CDS             complement(4276..5742)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_6"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.8e-10, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 1.2e-121,
                     bitscore: 401.1, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHPGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             6314..7057
                     /locus_tag="ctg3_7"
                     /transl_table=11
                     /translation="MEKEGVGMALPIAIVEDQTPDAQRLEELLQQQLPAAECTWFACGD
                     DFLRAASEPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVH
                     PFDYLLKPYQEEKFVHLAAELRRALRCKEPELEIRIARQSIQLPLRKVLYAIARNHYVL
                     ITTEDGEYRAMCSFAQIEEKLTALENFMSCNRGVIINMDKVLRFGEDCIEILDGTRLPV
                     RQKDKCTLLARFTQYQFRHMRQELH"
     CDS             7075..8391
                     /locus_tag="ctg3_8"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPRRTACIAAGCI
                     TLLCIGCAALCSVFGLSSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTVLNAQAEISNPQMVCLASTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLPALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFTRNAQLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLHQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILRSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEHLFRVNVLLNL"
     CDS             complement(8476..8715)
                     /locus_tag="ctg3_9"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKNTKKLEK"
     CDS             complement(8735..9211)
                     /locus_tag="ctg3_10"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
     CDS             complement(9624..11147)
                     /locus_tag="ctg3_11"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNGITVVKHYIDRA
                     LSAKTDNRPDFQQMIKDSEKRLFDIVLVWKLDRFARNRYDSAHYEYQLERNHVKLVSAT
                     EPISDSPAGIMVKSMLTGMAEYYSAELSEKVVRGMTENVLKGKYNGGTIPIGFKVDEEK
                     FFQVDPLKAPFVVEAFQRYNDGATMKELMNWLNDSGVTTNRNQKFTYNSVQTLLTNKRY
                     IGENHFKDIVMPDSIPAIVDKDLFEEVQLKIKKNSRAPARHKAEDDYLLTTKLFCGMCG
                     AMMFGECGTGRNKVVHHYYKCATAKRFKTCKKKTVRKEWLEDLVIAETMKLIQDDAVID
                     AIVAEVMELQDQENTTLPLLEKQMREVENGIENMLNAIQAGVLTNSTKLRLEKLEAQQK
                     ELEVRIAEEKIARPRLSENQVRFWLTRFRKLDPNVKSHRETLINTFENAVYLYDEKVLI
                     TFNYKDGTKTITFDEIAAKDAPEGNGSDLGCFAPPKSLSVCKCAEVFVL"
     CDS             complement(11161..11481)
                     /locus_tag="ctg3_12"
                     /transl_table=11
                     /translation="MKQYDVKISHAALSDMEQIYSYIADRLLEPDTAMGQYNRIAEAIQ
                     SLNILPERCALVESEPERTQGLRQMLVDNYSVFYIVGEDTVSVARVLYSASDLVRRLRR
                     MK"
     CDS             complement(11478..11783)
                     /locus_tag="ctg3_13"
                     /transl_table=11
                     /translation="MEKTMMLNVRVSPSVKQQAEDVLKQLGIPMATAIDMYLRQITLTG
                     GIPFSLSLPKAPAALNADTMTDDQLHAALQVGIKEIQNGDTVDAAGAFAQFREQHR"
     CDS             complement(12579..13088)
                     /locus_tag="ctg3_14"
                     /transl_table=11
                     /translation="MKKRAIIVLCLALVLTLIGCGNNTQSSDAHNAEYEEGYAAGYEAG
                     YNDGKQQIAESKKHFAQFSGSFMATVEQLLPDYYALPGKTIAVVHFFQDRPFLLHFQKD
                     LTGELVEGTSYVFEFETFEVELPDDEENPDISDYMYSINVTSYRVAEDDELGLEGKMPS
                     VEIVSK"
ORIGIN
        1 ccgtgacaaa cgctttttat tttactgtgc gcccaagcgc attttgaagt cctgatagcc
       61 gaagtgcacc agttccctgc aattgccgtc tgcgcccagc agccagatgg gcggcagggg
      121 catcccgttg aaggtgttgt tcttgcaggt ggtgtagatg gccatatcgc cgaagatgag
      181 cttatcaccc tcagcaaggg gggcgtcaaa gctgtaatcc ccgatgatat cccccgcaag
      241 gcaggtgggg ccgcccaagc ggacagtgtg cgctttctcc cccgcctcac cggcatccaa
      301 cagcggcggg cggtagggca tctcgatgac atccggggtg tggcaggctg cggacatatc
      361 cagaatggca aggctggtat ccccgttgcg cagggtgtcc agcacggtgg taaccagata
      421 gcctgcattc agcgcccaag cctcgccggg ctccagatac acctgtacgc cgtacttctg
      481 ccgcaccgag aggatgcagt tttccagcgt agcaagggca tagcccgggc gggtgatatg
      541 gtgccccccg ccgaagttga gccatttcat tctgggcagc aggtctgcaa actttttctc
      601 cactgcggcc agcgttaccg ccagcgcatc ggcgtcctgc tcgcacaggg tatggaagtg
      661 cagaccgtcc agcagggcgg gcagctccgg gtgcgccgcc acagcagcgt cccactgagc
      721 acgggtggtg cccagacggc tgccgggtgc gcaggggtcg taaatttcgt gcccctcctg
      781 cgtggagcac tccgggttga tgcgcagacc gatgcttttg cccgctgcct ttgccgccgg
      841 gccgaacttt gccagctggc tgggcgagtt gaacacgatg tggtcggcgt attgcagcaa
      901 ttcctcaaac tcatctgtcc ggtaggcggc gcagaacaca tggttctcct tctccggcag
      961 ctcttccctg cccaagcggc tctcgtacag gccgctggcc tcggtacctg ccagataggg
     1021 tgccagcacc gggtagacgt taaagttgga aaaagccttc tgcgccagca ggatgcggca
     1081 gccggtgcgc tgctgcacgc ccagcaggat ctcgccgttg cggcacagtt gggcttcgtc
     1141 cagcagatag cagggggtgg gcaggcggtg cagctgcgcc tcggacaggt ttgccagccc
     1201 cgcaaagggc gggcggctgt cgcgcacccg catcagtcca ccagagccgg gttatggctc
     1261 tcggagcggg gcaagccgta cttatccagt gcatccagat acggatcggg atcaaactct
     1321 tctacggtgt gcacgccctt ggtggtccac ttgccggtga gcagcatcag ggcaccacac
     1381 atagccggca cgccggtggt gtaactgatg gcctgactgc ccacttcttt gtagcactcc
     1441 tgatggtcac agacgttgta gatgtagtag gtcttatcct taccgtcctt tttgccggta
     1501 aagatgcagc cgatgttggt cttgccctta gtgcgggggc caaggctggc ggggtccggc
     1561 agcagagcct tgaggaactg gatgggcacg atctcctgtc cgttgaagtt gacgggggtg
     1621 gtggacagca tgcccacgtc ctccagacag cgcatgtggt ccagatagct ctggccaaag
     1681 gtcatgaaga agcggatgcg ctttgcctcc gggatgttct ttgccagaga ctcgatctcc
     1741 tcatggtgca gcagatacat atccttgtcg cccacctgat cgaagttgta ctcccgcttg
     1801 atgctcatgg ccgggatctc tacccagtgg ccgttctccc agtagctgcc gggtgcggac
     1861 acctcgcgca ggttgatctc ggggttaaag ttggtggcaa aggcatagcc gtggtcgccg
     1921 ccgttgcagt ccagaatgtc gatagtgtca atggtatcga actcatgctt tttggcgtag
     1981 gcacagtaag cctgggtcac gcccgggtcg aagccgctgc ccagcagagc ggtcaggccg
     2041 gcttcctcaa actttttggc gtaagcccac tgccagctgt aatcaaagta ggcagagaag
     2101 ccggcttcct tgcagcgctt ctcgtagatg gcgcgccact ccgggtcgtc ggtgttctcg
     2161 ggctcgtagt tggcggtgtc catgtagttg acgccgcagg caaggcaggc atccataatg
     2221 gtcagatcct gataaggcag ggcgatgttc atcacgaggt cgggctggta ggccttgatg
     2281 agggcgatga cctcctccac cttgtctgcg tccacctgtg cggtggtgat cttggtggcg
     2341 gtggtgggag ccagctcagc agccagctta tcgcactttg ccttggtacg gctggcgatg
     2401 cagatctcgg tgaacacctc gggcacctgg cagcacttat ggatggcaac agaggccacg
     2461 ccgccgcagc cgatgatcag aactttgctc atgtcggtta ctcctttatc tgtaaaatgg
     2521 taggttcgta tttatacctg aaagcccggc cagcccttgt ccagcgcgat cagggtctcg
     2581 cgcagcacct tgcaggcggt ggcggtggaa acgccggtgg tgtccagcgt gggggccagc
     2641 tcgttcaggt ctgcgccgat gatgttggcc ttggtcacag tgcggatggc atccagcagc
     2701 tgcaaaaagc ttacgccgcc agcttccggg gtaccggtac ccgggaagca ggaggggtca
     2761 agacagtcca gatcgatggt caggtacacc ggcaccttgc tctcgcacag ctgtgcggtc
     2821 agttcggcaa ggccggtaaa atcaaacttg tgcatctcgg tgtgctgggc agcaaactca
     2881 aactctgccc ggtcgccgct gcggatgcag aactgatgga tgcggccgtc ccctaccagc
     2941 tcgtggcagc ggcgcagcac acaagcgtgg ctgagcttcg cgcccagata gtcgtcccgc
     3001 aggtcggcgt gggcgtcgaa atggacgatg tgcaggtcgg ggtatttctt caccgcagcc
     3061 cgcacggcac ccagtgtgac cagatgctca ccgcccagca gcagcgggaa cttgccgtcc
     3121 ttcaaaatct cctctgcccg ggcctcgata tcggccagtg ccagctcgct ggagccaaag
     3181 cacagctcca gatcgccgct gtcgaacacg tcaaaatcgg tcaggtcggc gttctggtag
     3241 gggctgtaag tctccagacc gtagctctcg tgccggatgg ccgccgggcc gaaccgtgct
     3301 ccggggcggt agctggtggt ggaatcgtaa ggcgcaccgt acagcacgat gctggcggcg
     3361 cggtagctgc tgtcgcagcc gataaaggtc tcaacgttgg ggtgcatcag tgttcctcca
     3421 cttcccgcag catctcctcc agaaaagccg gcaggtaaaa tgctccgata tgcagtttgg
     3481 tggtatagta gcgggtgcgc atattcagcg ccttccacgc ttctgcgtcc agatcatcaa
     3541 tgggatggta tttttgcttg caaagccgaa cagccagtag cccgccgcaa aggtagggat
     3601 atgtgcctga tacacccggc tgatggggaa ggtggatgca atgcgcttgt ggctgcgctg
     3661 catggcactg gcatcttcgg cgtagaaggg actgccctgc tggttgacca tgatgccgtc
     3721 ctctttcagg gcgttgaagc agctgccgta gaactcgcgg gtgaacagac cctcagaggg
     3781 gccgaagggg tcggaggagt ccacgatgat gaggtcgtac tcctcctcgc agcggcggat
     3841 atacttcagg gcattctcaa aatagatatg cacccgacgg tcatccatac ggcaggcatt
     3901 gccgggcaga taggcgcggc aagcctccac cacctgtggg tccatctcca caaggtcgat
     3961 gcgctccacg cggtcgtagc gggtaagctc ccgcaccacg ccgccgtctc cggcgccgat
     4021 gaccagaata tccttggcct ccttgtgcac cgccatgggc acatggacga tcatttcatc
     4081 gtagatgaac tcgtcgcgct cggtcagcat cacgttgccg tccagcgtga gcacccggcc
     4141 gaactccggg gtctcaaaga tatcgatgcg ctggtaatcg ctctgcttgg agtagagctg
     4201 cttgtttaca cgaatgctgt gcttcacatc cggggtgtga aactctgaaa accaaaattc
     4261 catctctttc cctccttatg ccagaacatt caggtgcaag atttcggggt cctccgggcc
     4321 agtcatgctg cagcccttgg ccttggcgta ctcgatgtag ttcaagatct ccttggtgat
     4381 gcgctcgccg ggtgcaagga tggggatgcc cgggggatag cacatgacga actcgctgca
     4441 caccatgccc tcggtctccc gcaggggcag gctctttttc ggggcataga aggcctcctg
     4501 cgggctggca gccaccacgg ggtcgatgta ttcctgactc agcagacccg agccatcggt
     4561 gcggtagcgg cgcttgatct ccgccagcgc actgaccaga cgctccacct cctgcgggcg
     4621 gtcgccgatg gacaggtagg caaggatgtt gccgatatcg ccgaactcga tctgaatgtc
     4681 atactcgtcc cgcaggatgt cgtagacctc gatgccggca agaccaatat ccagcgtatg
     4741 gacgctgagc ttggtggtgt caaagtcaaa aacagaatcg ccgttgcaca gctccttgcc
     4801 aaaggcgtag tagccgccta cggcgttgat ctcctcgcgg gcatactcgg caatatctgc
     4861 cacctgatgg aatacctgcc gtccccgcag cgccagattg cggcgggaga tatccaagct
     4921 ggacatcagc aggtagctgc cggaggtggt ctgggtcagg ttgatgatct gacgcacata
     4981 gcccgggtgc acgttggggc cgatgagcag caggctggac tgagtcaggc tgccgccgct
     5041 cttgtgcatg gacaccgagg ccatatccgc gcccgccgcc atggcagaaa ccggcaggcc
     5101 gccgccaaag tagaaatggg tgccgtgcgc ctcgtcagca aggcagagca tcccggcgtc
     5161 gtgcgccatt tttacgatgg cacgcaggtc agagcagatg ccgtagtagg tggggttatt
     5221 caccagcacg gccacggcgt tggggtgctc cttaatggcc tttgccacct gctcccgctt
     5281 catgcccagc gaaatgccca gacgcttatc cacctccggg ttcacataca ccggcacagc
     5341 gccgcacagc accagcgcgt tcagcacgct gcggtgcacg ttgcggggca gaatgatctc
     5401 atcgcccctc ttgcaggcgg taagcaccat gctctgcacg ctgctggtgg tgccgcccac
     5461 cattaaaaag gcgtgtgctg cgccaaaggc atcggcggca agctcctcag cttcccggat
     5521 gaccgacacc gggtggcaaa ggttatccag cggcttcata ctgttcacgt ccacgcccac
     5581 gcactgctga cccagaaaag cggtcagctc cgggttgccg cggcctcgct tgtggccggg
     5641 cacgtcaaaa ggcaccaccc gcatctgccg gaaccgctcc agcgcctcgt aaatgggcgc
     5701 acggcgctga tccagccggg aacgtgcttt gttctcgttc atcttttcct ccgtccctgt
     5761 tcttcttttt gcacaacaaa aaagcgcaga cactgcacaa atgtgcagac ctgcgcttgg
     5821 agcagctttt tccgcgctga taaagcaccc agccgtaagt gccggtgctg cgcgttattc
     5881 gcgatccaaa aagacggggt gatgagagtc tatatagcaa ctacactttt actactctta
     5941 ttgaccgttt cacaagtctg cgcataggct gcgcaatttc atggttgtaa aggaaccaac
     6001 ttataaaatt tgagcttcaa actcaatcaa taatggcagc ttgcgccgcc ggtcggcagt
     6061 ggacccggct gtccgtatgg ccttagcccc gtttgggcgg tcccgagtaa attgctttga
     6121 aaagactctg caaggcggcg tctctcaaaa tcaacaaaag aataacatga ttcgccccgt
     6181 ctgtcaacaa aaactttttg gcagtcgccc gctgcgggtg tgcagggcgg cgctcggcgc
     6241 gcaaaatggg gcgttttgtg caaaaaagca gatgcccttc ccgccgcagt atgctataat
     6301 aaaggaacaa tgaatggaga aagagggtgt agggatggca ctgccaatcg ccatcgtaga
     6361 ggatcagacc ccggacgccc agcggctgga ggagttgctg caacagcagc tgcctgcagc
     6421 tgagtgcaca tggtttgcct gcggggatga ttttctccgc gccgcatcag agcccggcct
     6481 gtacgccgtg gtgtttctgg atatctgcat ggcgggcacc aatggcatcg agaccgcccg
     6541 ccgactgcgg caggccgacc cggaggtgct gatcgtattc gtgacctcct cgccggaata
     6601 tgtatgggat gcctttccgg tgcacccctt cgattacctg ctcaaacctt atcaggagga
     6661 aaaattcgtg caccttgctg ccgagttgcg gcgggcgctt cgttgtaagg agccggaact
     6721 ggagattcgc attgcccgcc agagcattca actgccgctg cgcaaggtgc tgtacgccat
     6781 tgcccggaac cactacgtcc ttatcaccac cgaggatggc gagtaccgcg ccatgtgcag
     6841 ttttgcgcag atcgaagaaa agcttactgc tctggaaaac tttatgagct gcaaccgggg
     6901 cgttatcatc aacatggaca aggtgctgcg gttcggggag gactgcatcg agatcttgga
     6961 cggcacccgc ctgccggtac ggcaaaagga taaatgcacc ctgcttgccc gctttacaca
     7021 ataccagttc cgccacatgc ggcaggagct gcactgagga aaggagcagc cgccatggat
     7081 cttgccctgt tcggccgtta ttttctggat tttgcactgc tgtaccccag cgcgtttctg
     7141 tgtctggcat ccctgtggga aaagctgcgc acccccaggc gcaccgcctg catcgccgcc
     7201 gggtgcatta ccctgctgtg catcggctgc gccgcacttt gctccgtgtt cgggctgagc
     7261 agcaattctc tcctgcccgc catcgtgctg gtctccttct ggctgctgcg ctggcgggta
     7321 acgccggaag tgaccgtaag ccagaccgcg tttctgtttt ccatctctgc cgtgatgatg
     7381 gcggtgtgtt ccctgctgtc gacggtgctc aacgcccagg ccgagatctc caacccacag
     7441 atggtctgcc ttgcctccac ggcgctgctg cggctgggcc ttgctgcgat gctcaccgtg
     7501 ctgttctggt tcaccgccgt gcagtggagc cggtggctgc tgcgggagta cagtggtgaa
     7561 gccttctggc agtctgcgtg gccgctgccc gccctctatg ccgtttttct ggtatactgt
     7621 atgccgctga accctgccgt ggtgctggtc gggcggctga agatcatctc ggtgctggcg
     7681 gtatccatct cgctgttcgg catctttctg ctgctgtacg agatgtaccg cgttgcccgg
     7741 gagtttaccc gcaatgccca gctggaccgg gaaaaccagc tgctggccat ggaatcccgc
     7801 cggtacatgg agttacagac ctatctggac aacacccgcc gtctgcggca cgacttccgg
     7861 cagcatctgc atgtgattgc cggactgacc gagaccgggc agctggagga gctgaaaagc
     7921 tatctgcacc agtacgaaag cgaactcagt gagcaccgcc ccagcctgtg cgccaatgcc
     7981 gccgtggatg cactggccgg atattacgac catgcagccg ggcagcagag cgttcctgtg
     8041 gagtggaaac tggcactgcc ccggcagctg cccatgccgg aggccgacct gtgcaccatt
     8101 ctgggcaatc tgctggaaaa cgccctgcac gccagtcaga agctgccgcc ggagcagcgc
     8161 cgggttcagg tgatggcgca gatgctcagt cccgccatgc tggggcttgt ggtggagaac
     8221 cgttacgacg gcatgctgaa aaagcagcag ggtatcctgc gctccaccaa gcacgagggc
     8281 accggcatcg ggctggtatc tgccgagacg gtagtgcaca aatataacgg caatctgcat
     8341 ctggagaccg aggaacacct cttccgggtg aatgtcctgc tgaatctgta gccaccggca
     8401 gaccaacgtg aaagcgttta caaaaagcag cgccgtcctt tgcagaaggt tttttctgcg
     8461 aagggcggcg ctgtattatt tttcaagctt cttcgtgttt ttttgtgcag cttccagttc
     8521 atccacccgc ttttgcaggg cggtgatctt atcgtccatt ttcaaaaatg tccagaccag
     8581 aacagccagc accagcgcgg gaggaacgac catccacagg gactgctgac accagagcag
     8641 cagcgaatag ccgccgaata cagtaaaaat aaatacggca aacagacttg cagccagtac
     8701 agcaaaaaat cccatacaga aagtctcctt tcagttattc ttccgtttct tcctcgtccg
     8761 ggtccagctc aatgctgaac acggcttttt tcagcttgcc gcagccctgc gccttcagac
     8821 cggatttata cggttccccc gccagataca gggcaaagcg tccctcgcac agcatcccgg
     8881 caatgctggt accggcagtg cctacggtgg tgtcggcagc ttcatcggtg ggcttggtgg
     8941 gcgtcagctc cgcaaggctt acctcaaaca gctcgctgcc gtctaagtca gtctccagcg
     9001 tgatgtgatt gtcgtggcgc tggaacagtg ccttgtcgga ggtctggggc gtgacagtgc
     9061 tcacggtgac caccgccttg tctccatcaa tgcgggtgcg cccggcagga agggtggtga
     9121 tatcccgcgc catgatgtac tcgatcacgg tgtccagatt atcgcttacg cccagatagt
     9181 tgggcaggtt gttcagggta tcgtagatca tagaaaaagt cctccgtctg tgttgtttca
     9241 gttacctgta tggtatcaca ggtcagggac agatgcaata tgtgtgcggg cagatgtcgc
     9301 gagccgcgca gaaaaggaac ctgggtcgcg gctcccagcg gctgcaccat gccttgggcg
     9361 gcacgcgcat cctgctggcc gcagccacaa cagttcctcc ctgtttctgc cgctggcagc
     9421 ggtcgtcgct gttgcacagg ggctttttac ccgccggact attcggcggg tcttacgagt
     9481 tgcgcttgcc gctttttccg cagccccttg gcagggcttt gaaaaagcgg agcgctgccc
     9541 cagcctcgcc tccctgtttc cgccgcaggc ggcggtcggc tccgctgctg ttcgaatcca
     9601 cccgctctat gagtttagcc ttgtcacaaa acaaaaacct cagcgcactt gcatacgctg
     9661 aggctttttg gtggagcgaa gcaacccaaa tccgaaccat tgccctctgg ggcatctttg
     9721 gcggcgattt catcgaaagt gatggttttt gtgccgtctt tgtagttgaa tgtaatcaaa
     9781 actttttcat catagagata aacagcgttc tcaaacgtat tgataagcgt ctcacggtgg
     9841 cttttcacgt tcgggtcgag cttgcggaac cgggtcagcc agaaccgaac ctgattttca
     9901 ctcaaccgag gccgagcgat tttttcttcg gcaatccgaa cctcaagttc tttctgctgg
     9961 gcttccagct tttccaaacg caatttggtg gagttggtca gcacacctgc ttgaatggcg
    10021 ttcagcatat tctcaatgcc attctctacc tcacgcatct gcttttccag taaagggagc
    10081 gtggtgtttt cctgatcctg caactccatg acttctgcaa cgatggcatc aatcacggca
    10141 tcgtcctgaa tcagcttcat ggtttcagct atgaccaaat cttccagcca ctctttacgg
    10201 acggtctttt tcttgcaggt cttgaaacgc ttcgcggtgg cgcacttata ataatgatga
    10261 acgaccttgt ttctacccgt accgcactcg ccgaacatca tcgcaccgca cattccgcag
    10321 aacagcttgg tggtgagcag gtaatcgtcc tcggccttgt gacgggcagg agcgcggctg
    10381 ttctttttga ttttcagctg cacttcctca aacaagtcct tgtccacgat ggccgggatg
    10441 ctgtcgggca tcacaatgtc cttgaagtgg ttttcaccga tgtaccgttt gttcgtcagc
    10501 agcgtctgaa cactgttgta ggtaaacttc tgattacggt tggtggtcac gccactgtcg
    10561 ttcagccagt tcatcagttc tttcatagtt gcgccatcgt tgtaccgctg aaaggcttct
    10621 accacaaagg gagctttcag cggatcgact tgaaagaact tctcctcatc caccttaaaa
    10681 ccaatgggaa tcgtgccgcc gttgtacttt cccttcagaa cattctcggt catgccgcgc
    10741 acaacttttt cagaaagttc tgccgagtag tattcagcca tgccggtgag catactcttg
    10801 accatgatac ccgcagggct gtcagagata ggctccgtgg cagataccag cttgacatga
    10861 tttcgttcca actgatactc atagtgggcc gaatcatagc ggtttcgggc aaaacggtca
    10921 agcttccaga ccagcacaat gtcaaacaac cgtttctcgc tgtccttgat catctgctgg
    10981 aagtccgggc ggttgtcggt ttttgcggaa agggcacggt caatgtagtg tttgaccaca
    11041 gtgatgccgt tcttttcggc gtaggccgta cactcgcgaa tctgaccttc gatggattct
    11101 tcgcgctggt tgtcgctgga atagcgggca tagatcacgg cggtcatgca aacacccctt
    11161 tcacttcatt ctccgcaggc ggcgcacaag gtcagatgca ctgtacagca cacgagccac
    11221 cgacacggta tcctcgccca caatgtagaa caccgagtag ttatccacca gcatctgccg
    11281 cagcccttgg gtgcgctccg gctcgctttc cactagcgca cagcgttccg gcaggatgtt
    11341 cagtgactgg atggcttctg caatgcggtt atactgcccc atagccgtgt caggttccag
    11401 cagacggtcg gcaatatagc tgtagatctg ctccatatcg ctgagggctg catgggaaat
    11461 tttcacgtca tactgcttca tctgtgctgt tccctgaact gtgcgaatgc gcctgccgca
    11521 tccacagtat caccgttctg aatctctttg atgcccacct gcaaggctgc atggagttgg
    11581 tcatcggtca tggtgtcagc gttcagtgcc gcaggagcct tcggcaggga cagagagaag
    11641 gggatgccgc cagtcagggt gatctggcgc aggtacatat caatggctgt tgccattggg
    11701 atgccgagct gcttcagcac atcctcggct tgctgcttaa cgctggggct gacccggacg
    11761 ttcaacatca tcgttttttc catggttatc acctcgaatt tattgtaatg ctttttgcat
    11821 tacaagtcaa tcgagtgcga agtcgcaatt gaaattctct atattacaca atatattcgt
    11881 cgttaaattg tttaaaacgc agaatattca ttcgctagaa taaatctttg gagtacgccc
    11941 agtttgtgct gggtggtgag attgagcatt atctctcact cagctgtgac catggcagat
    12001 ttagaggatt gacctttaat tggaatatac agataaaacc gacagccctc tacttgcagt
    12061 cgttgcaaat agagggctgt ctattattaa ctacgcattt taacaatgat ttttcttttc
    12121 aacaagcatt ccgataataa acgaaagtag gaaaacgagc agccaaatca aaactccgta
    12181 gtgtgccttg agctgccata cttttcctat atacatatcc ggcgtgattt ttgtggcgtt
    12241 tattttgata ataaaatcgc ccaacacttg tccgatcaaa attcctgtcc agtttccagc
    12301 tgttgtgata agagctgctc tatacatttc cagaaaacag aaagtaacgg atgcaaccca
    12361 tacacacaaa taataatggg ctgctgtcca ttcaaacaag tagatttcat gaaacactgt
    12421 ttgagagaga agatagcaca ccacatatgc taaaaatacg atcagcaaaa atccgagaca
    12481 agttttcttt tttgatgctg tgttcttcat acggcttttg aatcctattc caatgtgtac
    12541 cgccatcttt gtgtttcatt ataaaatagc ttgactgttt acttcgatac tatttcgaca
    12601 gatggcatct tgccttccaa tccaagttca tcatcttctg caactctata actggtaaca
    12661 tttattgaat acatataatc tgaaatatct ggattttctt catcgtctgg aagttcaact
    12721 tcaaaagtct caaactcaaa cacataagac gttccttcaa caagttcgcc tgtcaagtcc
    12781 ttctggaaat gaagcaaaaa aggcctgtct tgaaagaagt gaacaacggc gattgttttt
    12841 cccggaagcg catagtaatc gggcaagagt tgctcaactg tggccataaa agaacccgaa
    12901 aactgtgcaa aatgcttttt gctttcggct atttgctgtt tcccgtcatt ataccctgcc
    12961 tcgtagccag cggcatagcc ttcttcgtat tccgcattgt gcgcatctga actttgagta
    13021 ttatttccac agccaatcaa tgtaagtacc agcgcaaggc aaagaactat tatagccctc
    13081 tttttcatac ggtttcctcc ttctatgttt tttcttcgcc tttatcggac ttttccacag
    13141 cttttgcaaa atcgtcgaga aaaagttctg tatctttttc attcgtacca ctttacccca
    13201 ttattagaat tgaaaattag tagccctttg atataaataa gtaaacaatg aatccacccc
    13261 acaaaacaac ttcagcaatt atcaaacact tcaagtgttg ctgcaatttt tcggggtcaa
    13321 tttcgccttt tttcagaaaa tcataaattg aatttcgcaa tttatctatg tcttcctgct
    13381 tgatttccag tttcaaataa aaatttttcc cgaaaaggag ctggtgcatc ccataatata
    13441 ttgaaagcaa tattaaaaat gaagtaatac ttacaagcgc tggctgggtc cagcttattg
    13501 tcataccttc taccgatgta agatttctat aaaaaacaat atcacttaaa ccagctacaa
    13561 acaacagaaa attccaaacc aaaaatatat ataaagtttt cttcattgtc tataccttct
    13621 ttcactactg cccacatcgc tggcaatatc gaattcctac tttattttta tgctctcaat
    13681 ttttacaaat catcaaacct accctccttg ctttttgttt agataacgaa atttaagcct
    13741 gatttatttc gtttgtccac aaaatttttc aaaatcgtat agctgcacat aaatttccag
    13801 aagacttgta gcacaatcac gattttttct ttttattcaa agaaaccacc acggcagttc
    13861 cagccacaaa ttatccatgg cttgttcctc tgtctttttt gcgcggcctt tcgtcaggtg
    13921 aaagtatatc gccgtgccga tcagcggatg ttcctcgcca tcggtgaagc catagcggta
    13981 cagcagatag gtctgctccc gttgggtcag ccgtttcagg ccatcgtaca gctcccggcg
    14041 cgattcctgc tcttccataa cgctctgtgg ctgcatggcg taggggtcgg ctatggcttc
    14101 gatgcgccgc agttgttcct ctcccggcag aacatcgtcc agcgaaacac gctggtaaca
    14161 gataccgtcc ttatcctccg tcaccatccg ctgctcaaaa gcagtaaagg catcccgcac
    14221 catgtccatc atggcgttgc ggatggcagg agccgcatag gtc
//
