LOCUS       c00070_gnlPro..        15081 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EKGOBLFL_70.
ACCESSION   c00070_gnlPro..
VERSION     c00070_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 22:26:55
            Original ID  :: gnl|Prokka|EKGOBLFL_70
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15081
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15081
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[9909:14617]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      9910..14617
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15081
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15081
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..271
                     /locus_tag="ctg70_1"
                     /transl_table=11
                     /translation="YYNMREQIEPVMHIIDTAFAAMKAVGVEPRVKAIRGGTDGAQLSF
                     KGLPCPNIFAGGLNFHGRYEFVPIQNMEKAMNVIVKIAELVASK"
     CDS             303..1391
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GCV_T"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GCV_T_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_2"
                     /sec_met_domain="GCV_T (E-value: 8.3e-96, bitscore: 310.1,
                     seeds: 72, tool: rule-based-clusters)"
                     /sec_met_domain="GCV_T_C (E-value: 6.4e-25, bitscore: 76.9,
                     seeds: 348, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTTPFTEKHISLGAKMHEFAGYNMPIEYSGIIDEHLTVCQGVGV
                     FDVSHMGEFWVKGPHALDFLQKVTSNNIAALTPGKVQYTCFPNENGGIVDDLLVYHYEP
                     EKYLLVVNASNIEKDWNWCVSHNTEGAELENASEHMAQLGVQGPKAIQALQKLTSINLS
                     DHPYYTFTHGEFAGEKDVIISNTGYTGAGGFELYFCPEAAMKIWDAVFEAGAEFGIKPV
                     GLGARDTLRLEMGFCLYGNDLDDTTSPIEAGLGWITKFVEGKNFTNRPMLEKQKAEGTT
                     RKLVGFEMIDRGIPRHGYELYSTDGIAIGVVTSGTMSPTRKIGIGMGYIRPEYSKVGTE
                     ICIDMRGRKLKAVVVKPPFRKQ"
     CDS             complement(1482..2834)
                     /locus_tag="ctg70_3"
                     /transl_table=11
                     /translation="MNNPGENSDNIYYAVEVNGIQETIPSDEMGIIAISAPETDREFWQ
                     QIYLKNHLYEYFNDRGYKHKLRQEIDEESLDYLDKLNEIAYQDDYITSYVQGIFSKLNA
                     TTIDSNRGESLNIRIIQSSEPDAFMLPNGSMVISTGLLCTLDSEDELAAVIACELGHFV
                     LDHQVNNIYRAERRAKRAAFWADVFATTASAALDVAYWDDNEDAYAVSLVADIGAIASL
                     LSIPATDRLGMKYKTSQEISSDRLARQLLAFKGYNPDGIASALGKIIGYYNLHQRNKDI
                     PRYGSIGNLQKRIEKAGESHSLSARPYLRTTSDVVSFNASMNYANKRYKETARLIRKNI
                     DNRLATDNDYIILVKAEMALSNTEEVNNRCLAMLDKAQEMAGTSPNLDIYKQKILLLMR
                     MNKQAQAADILKEYITLLSAYEGQGIEGTEKEWTNKEIGWANQMLDRISRI"
     CDS             complement(3188..3439)
                     /locus_tag="ctg70_4"
                     /transl_table=11
                     /translation="MKKGIHPENYRPVVFKDMSNGDVFLSRSTCNTKETIEFEGETYPL
                     VKLEISSTSHPFYTGKSKLVDTAGRVDKFMSRYGNRKK"
     CDS             3628..4602
                     /locus_tag="ctg70_5"
                     /transl_table=11
                     /translation="MRKLLVLCSFWLCVATLGAQNAERKLYSVAFYNLENLFDTIHDAG
                     KNDYEFLPNGSYQWTAKKYESKLQNLSKVLGSLSRDLVPEGPAFIGVAEAENSRVLEDL
                     VKQPAISNYEFVHYEGPDRRGIDCALLYDPKQFSVTHSKLVLSTPFEGDTVHLTRGFLI
                     VDGQLAGERVCVIVNHWPSRGAKSPVRVHAARQVKALKDSLMRSDKKLKLIVMGDMNDD
                     PMDESMEVLGARKYPKQVKKGEFYNPWWVTLEDKGVGTLLYRGKWNLFDQIVISKPLLK
                     AKKGLRYDHNEVFIRDYLIQQDGKYKGSXXXXXXXQDLAERLQ"
     CDS             4919..5929
                     /locus_tag="ctg70_6"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHT
                     YTNPEEVIDFATRTGCDSLAISIGTSHGAYKFKPEQCHVDPATGRLVPPPSEFAVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVDTINKYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSENKLAQLD"
     CDS             complement(6400..8277)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_7"
                     /sec_met_domain="Alpha-amylase (E-value: 1.6e-63, bitscore:
                     205.1, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVXXXXXXXXXXXXXDKDVKPGKFNLTFT
                     EGKKKLVKEYELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDR
                     NDPNARHGGDLAGIEQHLDYFSNLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRF
                     GTNEEYKQLIEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSF
                     KLTPHVDPYTSQYDADQMNDGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRM
                     DTYPYADYDAMSIWMKELSEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTV
                     MDFSFFDKINTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEG
                     NNLPMLKQASTLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTP
                     AGRTKIQNECYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNG
                     TDAETTVPLKFYKEILKDSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(8388..9740)
                     /locus_tag="ctg70_8"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSAYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAINITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDASKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             complement(9910..11070)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_9"
                     /sec_met_domain="OAD_beta (E-value: 5.4e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(11072..11506)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_10"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.1e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(11530..12462)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_11"
                     /sec_met_domain="OAD_gamma (E-value: 1.2e-17, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(12494..14047)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_12"
                     /sec_met_domain="CT_Btheta (E-value: 1.5e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(14207..14617)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_13"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.8e-20, bitscore:
                     62.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKVSAL"
     CDS             14811..15080
                     /locus_tag="ctg70_14"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNS"
ORIGIN
        1 atactataat atgcgcgagc agattgaacc ggtgatgcat atcatcgaca ccgcttttgc
       61 cgccatgaag gcggtaggtg tagagcctcg tgtaaaagcc attcgcggag gtacggacgg
      121 cgcccagctc tctttcaagg gcctgccttg tcccaatatc tttgccggtg gcttgaactt
      181 ccacggccgc tatgagttcg tgcctatcca gaacatggag aaagccatga acgtcatcgt
      241 caagattgcc gagctcgtag caagcaaata gataattcat aactcataac tctaatagtt
      301 ccatgaaaac cactccgttt accgaaaaac acatctcgct gggtgccaag atgcacgagt
      361 ttgcgggata taatatgcct atcgagtatt ccggcatcat tgacgagcat cttacagtat
      421 gtcagggtgt cggtgtattc gacgtctcac acatgggaga attttgggtg aaaggtcccc
      481 atgctttgga ctttctgcag aaagtgactt ccaataacat agctgccctc acaccgggga
      541 aagtacagta tacctgcttc ccaaatgaaa atggaggcat tgtggacgac cttctggtct
      601 atcattatga gccggagaaa tacctgcttg tcgtgaatgc gtcgaacatt gagaaagact
      661 ggaactggtg tgtgtctcat aacacggaag gcgctgaatt ggaaaatgct tccgagcaca
      721 tggcacagct tggtgtgcaa ggaccgaagg ctattcaggc tttgcagaag ctgacttcca
      781 ttaatctttc cgaccatcct tactatactt ttacccacgg tgagtttgcc ggagaaaagg
      841 atgtcattat ctccaatacc ggatataccg gcgcgggtgg ttttgaactt tacttctgtc
      901 cggaggctgc catgaagatt tgggatgccg tgttcgaggc aggcgcggag ttcggcatta
      961 agccagttgg tctgggtgcg cgcgatacgc ttcgtctgga aatgggattc tgtttgtatg
     1021 gcaatgattt ggatgacacc acttcgccca ttgaagcggg tttaggatgg attaccaagt
     1081 ttgtggaggg aaagaacttc accaatcgcc cgatgctgga aaaacagaaa gcggaaggca
     1141 ctacccgtaa gttggtggga tttgagatga tagaccgcgg tatcccccgt catggttacg
     1201 agctgtatag tacagacggt attgccatcg gtgtggttac ctccggaact atgtcgccta
     1261 cccgtaagat tggtatcgga atggggtata tcagacccga atacagcaag gtcggtacgg
     1321 aaatctgcat tgacatgcgg ggacgtaagc tgaaagctgt ggttgtgaag ccgccgttcc
     1381 gcaaacagta gtttgaataa atgactgaga atgaagaatt tggctgcgca atgatgccgc
     1441 atgacaaatt cttcattctt cattcttagt tattcctttc tctatattct gcttatcctg
     1501 tccagcattt ggtttgccca acctatctct ttattggtcc attccttttc ggttccttct
     1561 atgccctggc cttcgtaggc cgaaagcaag gtgatatatt ctttcagtat atcagcggct
     1621 tgggcttgtt tgttcatgcg catcaataat agtatttttt gtttatatat gtccagattg
     1681 gggcttgttc ctgccatctc ctgggcttta tcaagcatgg cgaggcagcg gttgttcact
     1741 tcttccgtat tagacagtgc catttccgct tttaccagga tgatgtagtc attgtccgtg
     1801 gctagtctgt tgtcaatgtt cttgcgtatc agccgggcag tttccttata gcgcttgttg
     1861 gcgtagttca tacttgcgtt gaaagaaacg acatcgctgg tggtccgtag gtaggggcgg
     1921 gcactcaggc tatgggattc accggccttt tctatacgct tttgcaggtt gccgatgctg
     1981 ccgtagcgag gaatgtcctt gttgcgttgg tgcaggttgt aataccctat aattttaccg
     2041 agggccgatg cgattccgtc gggattatag cccttgaatg ccagaagttg gcgcgcaagg
     2101 cggtctgaag agatttcctg ggaagttttg tatttcatcc ccaaccggtc cgttgccgga
     2161 atgctcaaaa gggaagcgat ggctccgata tctgccacca gactgacggc ataagcatct
     2221 tcattatcgt cccagtaggc cacatcgagg gctgcgctgg cggtagtggc aaagacatct
     2281 gcccaaaaag ctgcacgctt ggcacgccgc tcggcacgat aaatgttgtt tacctgatgg
     2341 tcgaggacga aatgtcccag ctcacatgcg atgacggcgg ccagttcgtc ttcggaatca
     2401 agagtgcaga ggaggcctgt actgataacc atggagccgt tgggaagcat gaaggcatct
     2461 ggttcggacg actggatgat acgtatgttc aggctttctc cacgattgct gtcaatggtg
     2521 gtggcattca gtttggagaa tattccttgt acgtacgagg ttatgtagtc gtcctgatag
     2581 gctatctcgt tcagtttatc gagatagtcc aggctttctt cgtcgatttc ctggcgcagt
     2641 ttgtgcttgt aaccgcggtc gttgaaatat tcgtaaagat gattcttcag gtatatttgc
     2701 tgccagaatt cccggtccgt ttccggagcg gatatggcaa tgatacccat ctcatccgaa
     2761 ggaatggttt cttgtatgcc attcacttcg acggcatagt aaatgttatc gctgttttca
     2821 ccgggattgt tcattttgac aacccggcgg ataatgaccg gggtaccggc gggagattgc
     2881 tggtactctt ttgtcaattc tcctttgatg gcgatnnnnn nnnnnngctt aagtccttgt
     2941 gcttgggttt ggcaaaccct gccgttgtga caaggattgt taggatgaat agggtggcga
     3001 gtcgtttcat gattatggta tgttttcggt ttcgatgata caaaaatagg aaagtgtttt
     3061 tcccctttct tgttttttcc cctattctgt gataggagat tccctattta tcgctcagcg
     3121 ggaggcggaa acaaaaaagg gaacctttca gtgaaagact cccttttttc agtttgcttg
     3181 aaactgatta tttcttacgg ttaccgtaac ggctcatgaa cttatcaaca cgaccggcgg
     3241 tgtcaaccag cttggactta ccagtgtaga acgggtgaga agtgctggag atttccagct
     3301 ttaccagcgg ataagtttca ccttcgaatt cgatagtctc tttcgtgttg caagtggaac
     3361 gagacaagaa tacatcacca tttgacatat ctttaaatac taccggacgg taattttcag
     3421 gatgaatacc ttttttcatt ttgatatttt cttttaaaaa tttatattct gttactattt
     3481 tggtaataaa tagtgtaatg gtcttctttt cagagcgcaa agatagtgca agttggagac
     3541 tctacaaaat aaattcagat ttatttttat ttagtaggtt tatcgcattt tatttctgat
     3601 ttttgcagga cttaatcttg tgaatttatg aggaaactac ttgtcttatg ctctttctgg
     3661 ctgtgcgtgg caacgctggg ggcacaaaat gcggaacgga aactgtatag tgttgcgttc
     3721 tacaatcttg agaacttatt tgatacgatt catgatgcag gtaagaatga ctatgagttc
     3781 ctgcctaacg gcagttacca gtggacggca aagaagtatg agtccaagct gcagaacctt
     3841 tccaaagtgt tggggtccct ttcgcgtgat ttagtgccgg aaggtccggc attcatcggt
     3901 gtggcagagg cagagaacag ccgggtgctg gaagacctcg tgaagcagcc ggccatttcc
     3961 aattatgagt tcgtgcatta tgaaggaccg gacagacggg gcatcgactg tgccttgctg
     4021 tacgacccga agcaattcag cgttacccac tcaaagttgg tgctttccac tccttttgag
     4081 ggggatacgg tgcacttgac gcgtggcttc ttgattgtgg acggacaact ggcgggagag
     4141 cgtgtctgcg tgatagtgaa ccactggccc tcccgtgggg caaagtcgcc ggtgcgtgtg
     4201 catgcagcca ggcaggtaaa ggccttgaag gactctctga tgcgtagcga caagaagctg
     4261 aagctcatcg tgatggggga tatgaatgac gacccgatgg acgaaagcat ggaggtgctg
     4321 ggagcgcgca aatatccgaa gcaggtgaag aaaggcgaat tctacaatcc ctggtgggtg
     4381 acgctggaag acaagggagt ggggacattg ctctatcggg gcaagtggaa cttgtttgac
     4441 cagattgtca tttcgaaacc gttgctgaag gctaagaaag ggttgcgcta tgatcacaat
     4501 gaagttttca tccgcgatta tctgattcag caggatggca aatacaaagg ttccnnnnnn
     4561 nnnnnnnnnn nnnnncagga cttggctgaa cggttacagt gaccatttgc cgaccatcat
     4621 ctatctgaaa aattagtatt acataataat gtgtaaacag atgccggaga gcaaacatgt
     4681 tctccggctt ttttgttgat agaagtatag atggcaaaag tatggctggc agagataaat
     4741 gcaaagagtt tgtaatatag agattacaat aatctgttaa atgaagccaa tagctttaaa
     4801 atagaatgga tttggtagga tgagccggat attttattcc cgtcaagttc tttactttaa
     4861 aggataatga ttacttttgc gtagaatttt aattcactaa caataaaatt taaacaaaat
     4921 ggttaattac aaagatttag gactggtaaa cacaagagag atgtttgcta aggctatcaa
     4981 aggtggatat gctattccgg cattcaactt caacaatatg gaacagatgc aggctatcat
     5041 caaggctgca gttgaaacaa agtctccggt tattcttcag gtatctaagg gtgcccgtca
     5101 gtatgccaac gctacgctgt tgcgttacat ggctcagggt gctgttgagt acgctaagga
     5161 attgggttgc aaacatcctg aaattgttct tcaccttgac cacggagata cattcgaaac
     5221 ttgcaagagc tgtatcgact ccggtttctc ttcagtaatg attgacggtt cacaccttcc
     5281 gtacgaagaa aacgttgcac tgactaagaa ggtagttgac tatgcccatc agttcgacgt
     5341 aactgtagaa ggcgaactcg gtgtattggc cggtgtagaa gatgaagttt ctgcagaaca
     5401 ccatacatat actaatcctg aagaagttat tgacttcgct acccgtacag gttgcgattc
     5461 actggctatc tcaatcggta cttctcatgg tgcatacaag ttcaaacccg aacaatgcca
     5521 cgttgaccct gctaccggtc gtctggttcc tcctccttcg gaatttgccg ttctggatgc
     5581 tgtaatggag aaacttccgg gattccccat cgttcttcac ggttcttctt cagttcctca
     5641 ggaagaagtt gatactatca acaagtatgg tggtaagctg gaagctgcta tcggtatccc
     5701 cgaagagcag ttgcgtaagg ctgccaagtc tgctgtttgc aaaatcaaca tcgactctga
     5761 ctcacgtctg gctatgacag ctgctatccg caagacattt gctgaaaaac cggcagaatt
     5821 cgacccgcgt aagtatctgg gtccggctcg tgacaatatg gaaaaactgt acaagcataa
     5881 aatcatcaac gtgcttggtt cagagaacaa attggctcaa ctggactaat cgaaagataa
     5941 tccgaatata gcgtcagccc ttgcaatatt gatgttgcaa gggctgactt gttatatata
     6001 ggccggtgtt gtgggatggt taagttcgcc ggttatttca gaagcggatg tttcaacgtg
     6061 tacaacagtc tgtttccttt aacaaaacag tctgtttccc ttaactgaac agtttgtttc
     6121 aataaagaga acacttcgtt ccaatatgca aaaacacttc gttccaatac gtaagaacac
     6181 tttgtttcta catatccgaa cactttgttt ctctatactg gaacaaagtg ttcaccgtta
     6241 tgaactaaca gattagctat atttgagacc ggtgaaaagc atatccccgt gacacctatt
     6301 ccatactaaa aatcccttgc agatggctgg caggcgaggt gtctgcaagc tatctgcaag
     6361 ggagatttgc aagaatgagc tctctgtgtg gagtgcgcgt tataattcta tcactaatga
     6421 ttctctgggg cccatcttca gctcttcacc gaaggtgatg gccttgccgc taagaatatc
     6481 ttttccctgc ttgctgtctt ttaggatttc cttgtagaat ttcaaaggaa cggtggtctc
     6541 tgcatctgta ccgttcagca tcacgaatat cgtcttgcct tcgtactggc gtgcgtaggc
     6601 ataaacacca ttctgtacca tgaactgcac catgctgcct ttggcaatca catcgtttcc
     6661 tttgcgccag tttaggatgg tcttgtagaa gtcgtagcac tcgttctgta ttttggtacg
     6721 tccggctggg gtcagtgcgt ttgttgcgtc accggtccat ccgccgggga agtccttgcg
     6781 gacatagccg tcgctcttgc tcttcacgcc attcatcatg acttccgttc cgtagtagag
     6841 ttgcggaatg cggcgggtgg taagcagcag ggtagaggct tgcttcagca tcggaaggtt
     6901 gttgccttcg cccaggaagc ggtcggtgtc gtggttttcg atgaatgcca gtacggaagc
     6961 ggggttgggg tagaggaagt cgtatacgaa gttattgtat atgcggtcca gtcccttgaa
     7021 ccaagtttcg gtctgttcat tcttggcggt gtttatcttg tcgaagaagc tgaagtccat
     7081 aacggtcttg aggttactgt tcttgggggc tgatagcttg gaatccttct gccaccaggc
     7141 ggtgtaggcg ggttcggtaa cccaggtctc gcccacggtg ttgtagttgg gatattcttc
     7201 gctgagctct ttcatccaga tgctcatggc atcatagtcg gcatacgggt aagtgtccat
     7261 gcggatgccg tcgatgttgg cgaattcaat ccaccagaaa ctgttctgta ccaggtagcg
     7321 gtaaacgtga ggattcttct ggttgaggtc gggcatggaa ggtacaaacc agccgtcgtt
     7381 catctggtcg gcatcgtact gggaagtata agggtctacg tgcggggtca gtttgaagga
     7441 ggtctgcacg aagttgtttt cgtggtcggg gttgttgaac caatctttgg agggcatgtc
     7501 cttaatccat acatgctcta cgccgcagtg gttgaaaatc atgtccatta cgattttgat
     7561 gccgcgtgca tgggcttttt caatcagttg cttgtattct tcgttggtac cgaagcgcgg
     7621 gtctaccttg tagtagtctg tggtggcata gccgtgatag gaaccgccgg tcatgttgtt
     7681 ttccagtacc ggagtaaacc agagggctgt gacgccgagg ttggagaagt agtccaggtg
     7741 ttgttcgatg ccggcaaggt caccgccgtg gcgtgcattg gggtcattgc ggtctatctt
     7801 gtactcggcc atgcccgcaa tctggtcatt gtccgggttg ccattggcaa agcggtcggg
     7861 catcagcagg tacagtgcgt cggaggcgtc gaaaccttta tgttcgcaac ctttcttgtt
     7921 gcgtgccttc agttcatatt cctttacgag tttctttttt ccttcagtga aggtgaggtt
     7981 gaatttgccg ggttttacat ccttgtccnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8041 nnnnnnnacc aggaggtagt tgttgctttc cagcttgacg gtgctgctca atgagacgcc
     8101 gggataattg acggatactg ccgcgttgcc gatgccttcg ccatagacca tcagctggag
     8161 ttccgggttc tgcatgccgg tgtaccaaaa cggagggtcg attttgttca cattcatagc
     8221 tgcatacgta ctgagggaga gtaagagtgt tcccaagatt aagaatactt ttttcatgat
     8281 agtaacttta cggttaattt ttgcgctaat ttaaaacaaa taacggagaa agttaatctt
     8341 tctccgttac tgtaccttat tatattatgc aaacgttttc attggggcta tttgatgggg
     8401 gttacgctgg cggtatcgac ctttcccttg aagaagtcct ctttcttgcg cttttctctg
     8461 atgtccttca gccagttttc ggcggcattg tatcggttgt cttctccgat gatgggaact
     8521 ccgtccgcat ctacttcctg cactttgtcc ttgctgtttt tcggacgggt tttcaggtag
     8581 gccgttaggt atctctctgc tttggacgca tctttcagat agtaataata gataaaggct
     8641 gcgtcgtaga gcagtttgtg tttctgccgg tcgtattttt cgtattgcgt cagaagggta
     8701 ttcgcctggt cggtgtattg aaatgccatc ttgtagcagt ccgcaagccc cacatatagg
     8761 cgggacatga cactgtcgct gggcatggcg aggcttacgg cagtttccag ataagtcact
     8821 ccatcctctt tccatgatgt cttggagcag gcgcgtccca gataatagag aacgttgatg
     8881 ttggtattgt catctttaag agccctttcc agcaggtcgt gtgctgggta gaagtcttcg
     8941 agggcataat agctgattcc ggcgtagaag caggtttgga aagaactgtc tttttcctgt
     9001 aacagttgtt catatctttc tattgctttg gggtaatctt tgttcaggca ataggcttgg
     9061 gcattgatgc ggttcacaag gacgttggtg gagtctatgg aacggtattt ctccgttatg
     9121 tttatggcgt cttcatactg gtggcctgct acatagatgt tgccgagttt ggcagcagac
     9181 aggtaatcat tgggatatct tttctgtatg tccaggtagg catctatcac atgcatgatt
     9241 tctgtgttgt catagacttg ccccatactt tcggctctaa ggtgtagtac ataggcggaa
     9301 ctgtcccttt ctgccagcag gttgctttcc tttagagact cacggtatct cttcatgttc
     9361 atcagcagac tgatatactg gatgcgtgcg tatttattgt ccggatttat gtggagcgca
     9421 ttttggtagt aatccagtgc ctcgctatat ttggcaagtg atttgcagca ttcggcagct
     9481 tcaatgtatg cccggggatt gagagaatcc tgagctacga cttcctgaaa tacgctcaga
     9541 gcttcaaggt tattgcccag ccctttcagc gctttccctt tttggtagag tagggggacg
     9601 gtcggggttt cttgatcgat cagcatcaag gctgtttcat aatcgtagtt ggccatcgcc
     9661 tcttgaatgg gatttgtggt ctgtgccgcc agaagcgaac agcatgcact gaaacataag
     9721 gagataaaaa gctttcgcat acagtatatc atttatatga ggttaaactg actgcaagtt
     9781 actaaaaaga atgtatttac gaaataatcg taatctgttt tagatagatt aacgaaaaag
     9841 cccctccaaa aatgaagggg ctctaaaata gttcagaatt caagccggat aacggaatga
     9901 ataaatgtat tacattaaga atcccagcag gatacctgct gctacagcgg aaccgattac
     9961 accggcaacg ttcgggccca tggcatgcat cagcagatag ttggtaggat cgtattccag
    10021 acctactact tgggagatac gtgcagagtc gggtacggca gatacaccgg cattaccgat
    10081 caacggatta atcttgttgc ctttcttcag gaagaggttg aaaatcttca cgaagatgac
    10141 accggatgct gtggcaatga caaatgataa ggcgcccaga ccgaatatct tgattgaatc
    10201 aagggttaag aactcggatg cttgcgtaga agcacctact gtcaaaccaa gcagaatagt
    10261 aatggtatca atcagcggac cactggctgt gtttgccaga cgacgtgtaa ctccactttc
    10321 tttcagtaaa ttaccgaaga acagcatacc cagcaaaggc agaccggatg gtacaaggaa
    10381 tgtggttagt aacaaaccga taatcgggaa cattactttt tccgtatgtg aaaccacacg
    10441 gggaggtttc atacggataa gacgttcatt tttactggtc agccaacgca taataggcgg
    10501 ctgtatcacc ggtactaatg ccatatatga ataggctgat accgcaatgg cacccattaa
    10561 gttaggagcc agtttggaag agaggaagat ggcagtcgga ccatcggcac caccaatgat
    10621 accgattgca ccagcctgca tcgggtcaaa tcctatggca agggcaatca tataagcacc
    10681 gaatataccg aattgggctg ctgcaccaac caacattaat ttggggttcg atatcaaagc
    10741 agagaaatcc gtcatggcac cgatacccag gaatatgagt ggcgggtacc aaccggaggt
    10801 tactccctgg tacagaatat taagtacgga accttcttca tagataccga cttttaatcc
    10861 ggcttccata ttgaaaggta tattaccaat cagcataccg aaaccgatag gaattaatag
    10921 catcggctca aattccttgg ctacagccaa gtatatgaaa aacaaaccta ccagaagcat
    10981 taccacatgt cctaccgttg cattggcaaa acctgtataa gtccagaagt cggcaaggtt
    11041 gtttcctaaa aatgtgataa attctcccat attattcaat aattacgagg tcagtacctt
    11101 cgagaacaga gtcccctttg tttacattga tggctgtaat cttaccgtct ttatcagcat
    11161 tgatattgtt ttccatcttc atggcttcca aaatgatgat aacttgtccc ttctttactg
    11221 tatcgccgac atttactttg atatcgagga ttacaccggg aagcggagat tttacacctg
    11281 acttgccggt agaagcagcg gccggtttta ctaccggagt agcaggagca gcaggagcgg
    11341 atgtggctgc cggacgtgct accggtttaa caactacctt cggtgctttt tccatttcaa
    11401 ctttgtaggg agtaccgttc acttctacat gagcgatgtt gtcttcaata tctccaatgg
    11461 caactttata tacgttaccg ttaattttat atttatattc tttcatcgtt ttattttatt
    11521 atgggtgact tactttttgt gaggagtctc acgcaacgta taaatctttg aactccacgg
    11581 tgagtaactg cgttttacac gggtaatggt aagtatcgtg tcttccacat cgtgtacatc
    11641 gctttggaat tcgtgcatgg ccattgaaat ggcagcaaaa acttctcccg gagcctgccc
    11701 cagttgtttc tcttttgctt cttgtttatc agtaatacct ttagctttca tggcattgcg
    11761 tttgctgagg ttaactgata ttttacctat aatcttgaag gagatgtaga gtaatatcag
    11821 cccgcagaat acaacgctca tggcagaaat agccataccg atacctacgc tgtcatgctc
    11881 ttcgaatttt tccattttgg cattgctgtc gatagtcttg ttgttggtac tcggagtgac
    11941 atatttatct tcgcttccac cctttacttc ccattggtcg gctgcatcac tgacacgggc
    12001 ataggattgg ttggctttta aagtaccggc aggcactatg acttgatcaa gcaatttctt
    12061 gccggaatca tacaacccaa tccagttggc atttgtggca tccagtttga agttcgtatg
    12121 aaatgtaccg cgtcttggtt ctccatcagc ccagaaaagt gcatgctgac gtggttttat
    12181 gagtgtcaga acgtcacctt tgggaatgaa ataactggca gtatcacccg gctggctgct
    12241 gaatttcaga tagcaacctg caaggtcggc gctgccgtat gatctgttga agatttcaat
    12301 ccatgcgctg tgcacaccgt agtcatcctg atagttgctt tcgttgttga ccagcacttc
    12361 attcagcagc agtttgttgt tcgatttctg ttctttgcaa gaagagcaaa agcctaacac
    12421 cagcatcaat gaaaggaata ttccgatttt tgttttattc ataatcgttc ttgttttagt
    12481 gtgaaaagct tgattacaag ggaatattac catgcttctt agccgggtta gtcaatttct
    12541 tggtttgcaa ctgttgcagg gcacgaatga tgcggaaacg tgtgttacgc ggttcgataa
    12601 catcatcaat gtagccatat ttagctgcat tataaggatt ggcaaacaac ttggtgtatt
    12661 cagcctcttt ttcagccagg aattgagccg gattttcctg ctctttggct tcgcgggcat
    12721 ataatacttc tacagcacct gcaccaccca ttacagcgat ttcagcagta ggccaagcat
    12781 aattcatgtc gccacgcagc tgcttacagc tcatcacgat gtgcgaacca ccgtaggatt
    12841 tacgcagtgt gatggtaacc ttgggtacag tagcttcacc gtatgcatac agcagtttgg
    12901 caccgtgcag gatgacgccg ttgtactcct ggccggttcc cggaaggaat cccggtacgt
    12961 ctaccaatga tacgatagga atattgaagg cgtcgcagaa acggacgaag cgtgcgccct
    13021 tgcgggatgc gttgctgtcg agcacacctg ccagatactt cggctggttg gcaacaatac
    13081 ctacggactg tccgttgaaa cgtgcgaaac caataatgat attctttgaa taatcttttt
    13141 ggatttcgag gaactcacca ttatctatga tagcaccaat tacctcgtac atatcgtacg
    13201 gcttgttcgg gttatcagga atgatgtcgt tcagggaatc ttccagacgg tcgatagggt
    13261 ctgtacagtc tacataggga gcttcttcca ggttgttctg gggaatgtag ctcaacagtt
    13321 tgcggataag agccaaacct tcttcttctg tctgtgcagt aaaatgagta acaccagatt
    13381 tggtggagtg aacgctcgcg ccacccaggt tttcctggct tacgtcttct ccggttacag
    13441 tctttactac cttcggaccg gtaaggaaca tgtaggatgt accttccatc atcaaagtaa
    13501 agtctgtcaa ggcaggagag taaacggcgc caccggcaca aggaccgaaa ataccggaaa
    13561 tctgcggaat gacacccgaa gcaagtatgt tacgttggaa gatttcagcg tagccagcca
    13621 aggcattaat accttcctga atacgtgcac cgcccgagtc gttgataccg atacacggag
    13681 cacccatttt catggcttgg tccataatct tacagatttt cagagacatg gtttcggaca
    13741 gtgaaccggc agaaactgtg aagtcctgtg cgaagatata aaccagacgg ccttcgattg
    13801 taccgcaacc ggttactaca ccgtcaccgg ggtagtgttt cttttccatg ccgaagttgg
    13861 tgcatctatg ttctacgaac atgtccattt cttcgaaact gccttcgtcg agaagcatgg
    13921 ctatgcgctc gcgagctgta tatttaccct tctcgtgttg ctttgcaatc gctttttcac
    13981 caccaccgag acgtgctgca gcgcggcggt ctataagctc tttaatcttt tcaagttgat
    14041 tactcatgaa tttatattct ttaagtgttt atacaattta tgatttgatg attttacagt
    14101 cttgcttatt ccggtttctc gcaaagctcg gtcaggacac cgagagttga cttcggatgc
    14161 aggaatgcaa tgttcagacc ttctgcacct ttgcggggag ctttgtctat aaggcggata
    14221 ccttttcttc gacttcggca agcgcaccgg ccactccgtc ttcaacggca aatgccagat
    14281 gatgcatgcc accgttaccg ttgttctttt cgatgaactt ggcaattgtg ctttcgggag
    14341 aagtaggttc caacaattcg atctttacat cgcccacttt caggaaagcg gttctaactt
    14401 tctgatcttc cacggtttcg atgttgtagc atttcaaacc taaaacgttt tcgtagtacg
    14461 gaagggcttc ttcaatgctc ttaacggcaa tgcccagatg ctcaatgtgt gaaatcttca
    14521 taactatata aattaatgtt agtattgtat cctttttaat aaaggtataa agcagcacaa
    14581 agaaagagaa ttcttcctta ataaagaaat ttttcatcaa ttaattaatg gttaattgaa
    14641 ctttagaagg attttttcag actttagata gagaccggtt gttttcttga tatcgtccgc
    14701 taacggacat ccccactgtc cgaaaatgaa cacttacccc tctatgaaac ctttccggcc
    14761 acttggcaca ctctttgctt ttctgtttgc gacaatttta aagattgaac atgaaaaaga
    14821 atattttact tgcagtttgt tttttgatgc cgttggcaac catggcgcag aatgatactt
    14881 tgggacatga acgcaatatt acgctgtcgg aggccattgt actggcccgt acgcagtctg
    14941 tggatgctgc tgtggcattg aatgaattga aaaccgcgta ttgggaatac cgtacattcc
    15001 gtgcggactt gttgccggaa gtgaatttca ccggtacact acccaactat aacaagtcct
    15061 acagtaccta ccagaattcc g
//
