LOCUS       gnlProkkaDGLEAMLD_346   6209 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DGLEAMLD_346.
ACCESSION   gnlProkkaDGLEAMLD_346
VERSION     gnlProkkaDGLEAMLD_346
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 03:36:27
            Original ID  :: gnl|Prokka|DGLEAMLD_346
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6209
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6209
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[135:4488]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      136..4488
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..6209
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6209
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             38..139
                     /locus_tag="ctg346_1"
                     /transl_table=11
                     /translation="MINFTVGPVQSSDAVRVIGAEQVPYLEQQSFQK"
     CDS             136..888
                     /NRPS_PKS="Domain: Aminotran_5 (3-189). E-value: 1.1e-20.
                     Score: 65.7. Matches aSDomain:
                     nrpspksdomains_ctg346_2_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_2"
                     /sec_met_domain="Aminotran_5 (E-value: 7.1e-19, bitscore:
                     57.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDK
                     ALVINGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETF
                     TGVHYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIA
                     VMLLAPSAIKRIEKVQCCCQYLDLKLALKNMERGQTPCTPAVGILRQINVRLKEIESAG
                     GAEVEIARCAELAKYFRDKLVKNNLPLF"
     aSDomain        145..702
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg346_2_Aminotran_5.1"
                     /evalue="1.10E-20"
                     /label="ctg346_2_Aminotran_5.1"
                     /locus_tag="ctg346_2"
                     /protein_end="189"
                     /protein_start="3"
                     /score="65.7"
                     /tool="antismash"
                     /translation="ENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDKALV
                     INGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETFTGV
                     HYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIAVML
                     LAPSAIKRIEKVQCCCQYLDLKL"
     CDS             885..1259
                     /locus_tag="ctg346_3"
                     /transl_table=11
                     /translation="MTYRQVGTNSFTVKYYVEKFILDMNTMKIIRVDEYRDKKKINRPA
                     GSLFSVDGEIYRVAQKCSRAYGESIFVYKTSKNFDFIKDKKVAELTGQSIVLSDGRKPI
                     LLHTYSQAGGIEVIDYRCSL"
     CDS             1284..2594
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_4"
                     /sec_met_domain="CTP_transf_like (E-value: 8.2e-13,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.5e-115, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 5.9e-62, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             2629..3756
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.6e-21, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-24, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             3760..4488
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_6"
                     /sec_met_domain="Metallophos_2 (E-value: 3.1e-28, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             4489..5484
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg346_7_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg346_7"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 6.6e-10,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.3e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        4738..5082
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg346_7_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg346_7_NAD_binding_4.1"
                     /locus_tag="ctg346_7"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             5481..6209
                     /locus_tag="ctg346_8"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKKELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVR"
ORIGIN
        1 ggttgattat tactgataat taaaggaatc tatataaatg attaatttta cagtaggtcc
       61 ggtgcaatct tctgatgctg tacgggtcat aggtgccgaa caggtaccat atttagaaca
      121 gcagagtttt cagaaatgat gcttgagaat gagcgccttg ttaagaaatt tgctaatgcg
      181 actaaagata gtaaggttgt tttcatgaca tgttctggct ctggtggtat ggaggctgcc
      241 atcataaatt gccttacgcc acaggataag gctcttgtaa tcaatggtgg tagctttggt
      301 gagcgttttg tggaattgct tacccttcat aaaattcctt ttacggaaat taagcttaag
      361 tatggtagag ctttgaagcc tgaacatctt gctgaatatg agagcaaggg ttacactact
      421 ttccttatgc agaagcacga aacttttacg ggggtacatt acgatatcaa tcttgtttct
      481 gatttttgca aacgtaataa ttgtttcttg attgttgata taatctctac cttcctttgc
      541 gattcatttg atatggtggc aatggatgta ggggtgatga ttactggaag tcagaaggct
      601 cttgcttgcg ctccgggtat tgcagttatg cttcttgctc cttcggctat taaacgtata
      661 gaaaaggtcc aatgttgctg tcagtatctt gatttgaagc ttgctcttaa aaatatggag
      721 agagggcaga ctccttgtac tcctgctgtt ggtatccttc gtcaaattaa tgtccgttta
      781 aaagaaattg agtctgcagg tggtgcggag gtggagattg cgcgttgtgc agaattggct
      841 aagtattttc gtgataagct tgttaagaat aatcttccac tcttttgact tatcgtcagg
      901 ttggaacaaa tagctttaca gttaagtatt atgttgagaa gtttattctt gacatgaata
      961 cgatgaagat aattagggtt gacgagtatc gcgacaaaaa gaagattaat cgtcccgcag
     1021 gttcgttatt ctctgtagat ggagaaattt atcgagtggc acaaaaatgc agtcgtgcat
     1081 atggagagtc gatctttgtg tataagacaa gtaagaattt tgattttatt aaagataaaa
     1141 aggtagcaga actcactggt cagagtatag tcctgagtga tggtagaaag ccgattttgt
     1201 tgcacactta ttctcaagca ggagggattg aggtgattga ctatagatgc tctttataat
     1261 aatttgaaaa atgttaaata ataatggcaa agacagttta tcttggtatg ataggtgata
     1321 tcatgcatcc gggttacatt aacatcatta acaaagctac tgagtatggc gatgtgataa
     1381 tcggtttgtt cactgataag gcgattgcta accaccgtag acttccttat ctcacttggg
     1441 agcaaagaaa gaacgttgtt gagagcatca ggaacgtatc aagggtggtc cctcaggatg
     1501 attggagcta tgtctctaat ctccttaagt acaagcctga ttacatcatt catggtgatg
     1561 attggcaggt gggtcctgac aagtatatcc gtgatgaggt attcaaagta atggaaaagt
     1621 tgggtggtga ggttatcgag attccttaca cccaaaacat ctctgcttct ggtatcaaac
     1681 aagagattga tgctcttggt gtaactcctc agatgcgtct ttcttctctc cgtcgcctta
     1741 ttgcagctaa accgattgta cgtattcttg aaagtcacaa tggtcttact ggcctcatag
     1801 cagaacatac taaggtagag gtgaatggtc aggagcgtga attcgatggc atgtgggctt
     1861 cctcccttac cgactctacc tctaagggta agcctgatat tgaggctgtc gatttgacta
     1921 cccgtctcca tgacctcaat gatacccttg aagtaaccac aaaacctgtt atcttcgatg
     1981 gcgatactgg tggcaagatt gaacacttcg gttttaccgt tcgcaccctt gagcgcttgg
     2041 gaatctcttg cgttataatt gaagataagg taggtttaaa acagaattca ctttttggta
     2101 ctgatgctgt acagactcag gatacaatcg aaggttttca ggctaaaatt cgtgcaggta
     2161 aggaagcgca aattactcgt gacttcatga ttgtcagccg ttgtgagtct ctcattgctg
     2221 gtaagactgt agatgatgct ttggagcgtt gtcatgctta cgtagaggca ggtactgacg
     2281 gtataatgat ccactccaaa gagaagtctg gagaggacat caaggagttt tgcttgcgct
     2341 ttcgcgagaa gaatgctcat actcctatca tcgttgtgcc tactacttat aaccagttca
     2401 cagaagagga acttgctgaa tggggtatta atgtagtgat ttatgctaat cacatgcttc
     2461 gttctgctta tcctgcaatg gttaaatgtg cagaaaccat cctctatact agccgttcgc
     2521 ttgaagcatc tgagcagtac tgtatgccta tcaaacagat tcttaatctt attccaggca
     2581 caaagaagaa gtaaacatta atttcttacc ccttaaacta ttttacaaat ggtaagaccc
     2641 gaattttttg taaatatact caaggaacaa ggtatagact tttatgctgg tgttcctgat
     2701 tcgttgctca agaacatttg tgcatatatt accgaccacc ttcctgctga gcagaatatt
     2761 attgctgcta acgaaggagg ggccatgggt attgctgtag gttatcattt ggcaacaggt
     2821 aaggtgcctg tagtttatat gcagaactct ggtgaaggca atatcattaa tccgtttgcc
     2881 tctcttaccg acaaggacgt ttataacatt cctgtgctcc tcgttatcgg ttggagaggg
     2941 cgccctggag ttcacgatga acctcagcat gtgaagcaag gtaaggtgac aatcggtttg
     3001 cttaatacca tgggtatcaa ctatgctatt ctgccaaagg atgaagaggg agctgcaaag
     3061 cagataaaaa tagctgtcga cttcatgaag gcaaccaacg agtgctatgc ccttgtgata
     3121 gagaaggata ctttcgatac ctataagctt cagagcgttg aggtaaacga actggcaatg
     3181 tctcgcgaag agacgattca gaaggtggct tcaaacattg aagataatgc ttgtatcgta
     3241 tcaactactg gtatgatttc tcgcgagctc tttgaggcac gtactgcttg gagccaaggt
     3301 catgaacgtg atttccttac tgtaggggcg atgggccatg cttcccagat agctctcggc
     3361 atagctctcc aaaagcctga gcgtcgagta tattgttttg atggtgatgg agccagcatc
     3421 atgcacatgg gtaatatggc tattacagcc agcatgaaat gcaagaatta tgtgcacatt
     3481 gtgttcaaca atggcgcaca cgattctgtt ggtggtcagc ctactgttgg tctcaagatt
     3541 gatttttgtg caattgctca agctgtaggc tacaaggctg cttatagtgt agaaactatg
     3601 gaggcacttg aagcaaaact tgcagaattc aagaacgcag aaggtcctgt tttccttcag
     3661 atttgcgtaa aaaagggaaa ccgcaaggac cttggccgtc caactacaac tcctattcag
     3721 aacaaagagg cttttatgga atttcttaac aagtaaagta tgaaagtaat tctgtttgct
     3781 gatatacacg ccaatctttc tgcttttgag gcggttctag ctgatattga gaaacactat
     3841 cagccagatg ccatgattag tctaggtgac tttatcgact atggtatgcg ttcaaatgaa
     3901 attattgaac gtatacaaac tgttaatatt ccattacttg ccaatttgaa gggcaatcac
     3961 gagaaggctt tgattgatgg ggaactctca tgtttctctt cagaaagagc tcgtgtgatg
     4021 tccaaataca caagaaacca tctcactcag acatctattg attatataag caatgtgatg
     4081 caagagccaa tgcaagagtt ggaaattggt ggtaagaaag tacttctttt acatggaact
     4141 attgatgatc cctattgggg aaaactgact ccagcaaaag tggaagatga aaagtatcag
     4201 gattttgact acgtattgag cggtcacatt catcaacctt ttaagataga tgtattcttc
     4261 aaagttgaca atccaatcat gcgcaatcag aaacgtacga cttttatcaa cccaggttca
     4321 gttggacaac ctcgcaatca gaatccatat gcacaatatg tgtatatcaa ttttaaaacg
     4381 ggggaaaccc atttcaatgc agttccttac gatattgaag ctgaacaatc tcttttcccc
     4441 aaagagatag atacttttta cagcgaacga ttaaaatttg gaatataaat gaagaactta
     4501 tatgtaataa gtggtgttac tggcatgacg ggtagtgaac tgtctcgtca gtttgtttct
     4561 cagggtcata cggtaatcgg tttcgacaac ttctttgcaa gttctattga taccgttaaa
     4621 gacattattg acaatccctc gttcatcttc tataattacg acattaacaa agtcgctcag
     4681 atggatgaag tatgcgataa ggcgaaagaa ctcaaaattg agtgcgatgg ccgtctggtg
     4741 tttatcaatt gtgctgctgt tgtccataca aagcatttct atgaggtaga gagtactttt
     4801 cagactaacg tccttgctat gaaggatttc ttggagcgtg ccatttctat gagggctgat
     4861 acttacatta attgttcaac ttcggaggtt tactcaatgc agtcttggaa tgagaatggc
     4921 ggtgtgaaag aatctgatta tttggcaatg tcaacagcgg aacatagcca acgtacaagt
     4981 tatgcttgcg gcaagttgat gactgaattc tttatgaaag atgctgttgg caagggacga
     5041 attaaaggtt gttctattcg ctttgctaat gtatatagca ggcacgagcg ttttgcagag
     5101 cacattatcc ctcatatcat tgataatctg cttgaaagcc ataccgtaac ccttcttgaa
     5161 aactcgaagg tgaacaaacg taccttcctt cataatattg atagctgtcg tgccgttatg
     5221 gagctcatcg cttctgagga tgctcttgat ggtactgttt ataatgtggc tactgaagag
     5281 gaaattgcca ttattgatct agtcaagacg attgcaataa aaatgggcat caacgatgtg
     5341 gatatccgtt tcgaaggtta ccgaaagtct gatcctgagc gtcgattgct caatacggac
     5401 aagattcgta cccgtactag ctggaaacct atcatcactc tcgatgaagg cctcacgatg
     5461 tgtgtaaata gtatcaagaa atgaaatatt tgattataac tgttgctgga acggctacgc
     5521 gttttaatcg cgacactaag gaagaaaccc tcaaatgctt gtattatacc gatgaacctc
     5581 aatacgctct tcttgctcaa ttgctgaaga attgtggtga gtacgataaa tatatccttg
     5641 tggggggcta cctttatgag aagttgggaa gatttgtaaa gaacgaactc tctggttatg
     5701 gcaaaaaaaa agaacttgtt tacaacgagc atttcaaaga ctatggctcc ggctacagtt
     5761 tatacaaagg tatagaggca ataaaggagg caggtgatgt gactttcgta gaaggcgact
     5821 tgttctttat ggctacagat ttcaggcaag tgtataattc gccaaagagt gtgattacca
     5881 ttaaccgaga accaatctac tcgaataagg cagttgcgtt atacattaac gttgatggca
     5941 aaccaaggta tttatatgat acgaatcatc agacattaac tgtatcagag ccattcaagg
     6001 caatcttcaa cagtggtcag atgtggaaat tttcttcatc tgagaggctt ttgaagactg
     6061 ttgattcgct tacaaaagaa caacttcaag gtactaatct tgaaataatt caggcttact
     6121 ttagtgatat gaatagtgaa gagtatgatg tagtgacttt cactgactgg ttcaactgca
     6181 atactgttgc agattatgat attgtaaga
//
