LOCUS       c01113_gnlPro..        16291 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DGLEAMLD_1113.
ACCESSION   c01113_gnlPro..
VERSION     c01113_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-03 22:58:10
            Original ID  :: gnl|Prokka|DGLEAMLD_1113
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16291
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16291
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1756:6465]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1757..6465
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16291
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16291
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(76..1563)
                     /locus_tag="ctg1113_1"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             1757..2269
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1113_2"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.5e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             2328..3881
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1113_3"
                     /sec_met_domain="CT_Btheta (E-value: 1.5e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             3913..4845
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1113_4"
                     /sec_met_domain="OAD_gamma (E-value: 1.2e-17, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             4869..5303
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1113_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.1e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             5305..6465
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1113_6"
                     /sec_met_domain="OAD_beta (E-value: 5.4e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             6635..7987
                     /locus_tag="ctg1113_7"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSAYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAINITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDASKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             8098..9948
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1113_8"
                     /sec_met_domain="Alpha-amylase (E-value: 1.1e-63, bitscore:
                     205.6, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDRNDPNARHGG
                     DLAGIEQHLDYFSNLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQYDADQMNDGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYD
                     AMSNWMKELSEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKI
                     NTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEGNNLPMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNE
                     CYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPL
                     KFYKEILKDSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(10419..11429)
                     /locus_tag="ctg1113_9"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHT
                     YTNPEEVIDFATRTGCDSLAISIGTSHGAYKFKPEQCHVDPATGRLVPPPLEFAVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVDTINKYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSENKLAQLD"
     CDS             complement(11712..12719)
                     /locus_tag="ctg1113_10"
                     /transl_table=11
                     /translation="MRKLLVLCSFWLCVATLGAQNAERKLYSVAFYNLENLFDTIHDAG
                     KNDYEFLPNGSYQWTAKKYESKLQNLSKVLGSLSRDLVPEGPAFIGVAEAENSRVLEDL
                     VKQPAISNYEFVHYEGPDRRGIDCALLYDPKQFSVTHSKLVLSTPFEGDTVHLTRGFLI
                     VDGQLAGERVCVIVNHWPSRGAKSPVRVHAARQVKALKDSLMRSDKKLKLIVMGDMNDD
                     PMDESMEVLGARKYPKQVKKGEFYNPWWVTLEDKGVGTLLYRGKWNLFDQIVISKPLLK
                     AKKGLRYDHNEVFIRDYLIQQDGKYKGSPLRTHGGRTWLNGYSDHLPTIIYLKN"
     CDS             12908..13159
                     /locus_tag="ctg1113_11"
                     /transl_table=11
                     /translation="MKKGIHPENYRPVVFKDMSNGDVFLSRSTCNTKETIEFEGETYPL
                     VKLEISSTSHPFYTGKSKLVDTAGRVDKFMSRYGNRKK"
     CDS             13337..14860
                     /locus_tag="ctg1113_12"
                     /transl_table=11
                     /translation="MKRLATLFILTILVTTAGFAKPKHKDLSGNIAIKGELTKEYQQSP
                     AGTPVIIRRVVKMNNPGENSDNIYYAVEVNGIQETIPSDEMGIIAISAPETDREFWQQI
                     YLKNHLYEYFNDRGYKHKLRQEIDEECLDYLDKLNEIAYQDDYITSYVQGIFSKLNATT
                     IDSNRGESLNIRIIQSSEPDAFMLSNGSMVISTGLLCTLDSEDELAAVIACELGHFVLD
                     HQVNNIYRAERRAKRAAFWADVFATTASAALDVAYWDDNEDAYAVSLVADIGAIASLLS
                     IPATDRLGMKYKTSQEISSDRLARQLLAFKGYNPDGIASALGKIIGYYNLHQRNKDIPR
                     YGSIGNLQKRIEKAGESHSLSARPYLRTTSDVVSFNASMNYANKRYKETARLIRKNIDN
                     RLATDNDYIILVKAEMALSNTEEVNNRCLAMLDKAQEMAGTSPNLDIYKQKILLLMRMN
                     KQAQAADILKEYITLLSAYEGQGLEGTEKEWTNKEIGWANQMLDRISRI"
     CDS             complement(14951..16039)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GCV_T"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GCV_T_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1113_13"
                     /sec_met_domain="GCV_T (E-value: 2.8e-97, bitscore: 314.9,
                     seeds: 72, tool: rule-based-clusters)"
                     /sec_met_domain="GCV_T_C (E-value: 6.4e-25, bitscore: 76.9,
                     seeds: 348, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTTPFTEKHISLGAKMHEFAGYNMPIEYSGIIDEHLTVCQGVGV
                     FDVSHMGEFWVKGPHALDFLQKVTSNNIAALTPGKVQYTCFPNENGGIVDDLLVYHYEP
                     EKYLLVVNASNIEKDWNWCVSHNTEGAELENASEHMAQLAVQGPKAIQALQKLTSINLS
                     DLPYYTFTHGEFAGEKDVIISNTGYTGAGGFELYFYPEAAMKIWDAVFEAGAEFGIKPV
                     GLGARDTLRLEMGFCLYGNDLDDTTSPIEAGLGWITKFVEGKNFTNRPMLEKQKAEGTT
                     RKLVGFEMIDRGIPRHGYELYSTDGIAIGVVTSGTMSPTRKIGIGMGYIRPEYSKVGTE
                     ICIDMRGRKLKAVVVKPPFRKQ"
     CDS             complement(16071..16289)
                     /locus_tag="ctg1113_14"
                     /transl_table=11
                     /translation="AFAAMKAVGVEPRVKAIRGGTDGAQLSFKGLPCPNIFAGGLNFHG
                     RYEFVPIQNMEKAMNVIVKIAELVASK"
ORIGIN
        1 attcacctat aatatcgcat atacggtact tttaccggca aataattcat aacttatcac
       61 ttgcaacccg tcgacttatc ctcttaccac ctcttcaaaa tcagcttcca attccgtatc
      121 gcgttcaaaa tcccaaaggg tcaagctgcg gagctgatag aagtaatacc aatagtagta
      181 cagctctgaa atatgctttt gacgggcttc gtctttagag ttctgtgcat cgttcaggtc
      241 cagggtgctg attttaccta tcataaaggt ctctacactg gtcttgtaac gcttctcagc
      301 aatgacatcc gcctcttcgg ctatgtccag ctgttgcgcc tggttgttga agttagccac
      361 cagcaaaaag atgtcctggt taaagtccat ctgttcctga cggattctgg acaagaccac
      421 ttcacggttg ctctttgcca cccttacctt gccgcggcgc ttgccccagt caaggatagg
      481 aatcttgacg cctacctgca caatctgatt atcaagcaag tcccggtagg ctgaagagaa
      541 ttcatggttc tgccccgtat agcccacact ggcaaagagg tcgatgctgc gcaagtttcc
      601 gcgtgccgtt gccacttcat aatcagcttc gagctggcgg cggcgaatgt tctgtgcaaa
      661 ggagttgcgt tccagtgcct tgttcagcac acggtcatac tccatcttta tatcgggaac
      721 agtggcgggc aacaccggat tcaggctttc ctgctcggac accccgagga aagaacggag
      781 ctggaacatt tttgcattca ggttgctctc tgcctcagtc acgtcggcct tgccctgcaa
      841 tgaattcagt ttaagctgca acaaatcatt ctcggatatc tgtcccattt tacgtttggc
      901 tatggccact tcataaaggc ggtcggcatt cgtcttgttc tgcatggcgg tagcgagcga
      961 ttctttggcc agcagcaact caaagaaata agtgatggtt ttcatcgtca cctcttccgt
     1021 agctgaaatg aactcggcct ttgcctcggc atagcgtacg ggctctatac ggcggttcca
     1081 cttcaaggta ttcactccga agaccggttg cgtcaactcc agactcacgg ggactgacat
     1141 gaactgcttc gctcctccgg aacccagttg tttgagataa tccagcgaag aagtcagtga
     1201 cagcttaccc cccgtaaacc aaatgttctg gtctaccgaa agctgtccgg acagccccag
     1261 tgtattgttg cgaacaaagc tataggagcc gtcggaattc tggtaggtac tgtaggactt
     1321 gttatagttg ggtagtgtac cggtgaaatt cacttccggc aacaagtccg cacggaatgt
     1381 acggtattcc caatacgcgg ttttcaattc attcaatgcc acagcagcat ccacagactg
     1441 cgtacgggcc agtacaatgg cctccgacag cgtaatattg cgttcatgtc ccaaagtatc
     1501 attctgcgcc atggttgcca acggcatcaa aaaacaaact gcaagtaaaa tattcttttt
     1561 catgttcaat ctttaaaatt gtcgcaaaca gaaaagcaaa gagtgtgcca agtggccgga
     1621 aaggtttcat agaggggtaa gtgttcattt tcggacagtg gggatgtccg ttagcggacg
     1681 atatcaagaa aacaaccggt ctctatctaa agtctgaaaa aatccttcta aagttcaatt
     1741 aaccattaat taattgatga aaaatttctt tattaaggaa gaattctctt tctttgtgct
     1801 gctttatacc tttattaaaa aggatacaat actaacatta atttatatag ttatgaagat
     1861 ttcacacatt gagcatctgg gcattgccgt taagagcatt gaagaagccc ttccgtacta
     1921 cgaaaacgtt ttaggtttga aatgctacaa catcgaaacc gtggaagatc agaaagttag
     1981 aaccgctttc ctgaaagtgg gcgatgtaaa gatcgaattg ttggaaccta cttctcccga
     2041 aagcacaatt gccaagttca tcgaaaagaa caacggtaac ggtggcatgc atcatctggc
     2101 atttgccgtt gaagacggag tggccggtgc gcttgccgaa gtcgaagaaa aaggtatccg
     2161 ccttatagac aaagctcccc gcaaaggtgc agaaggtctg aacattgcat tcctgcatcc
     2221 gaagtcaact ctcggtgtcc tgaccgagct ttgcgagaaa ccggaataag caagactgta
     2281 aaatcatcaa atcataaatt gtataaacac ttaaagaata taaattcatg agtaatcaac
     2341 ttgaaaagat taaagagctt atagaccgcc gcgctgcagc acgtctcggt ggtggtgaaa
     2401 aagcgattgc aaagcaacac gagaagggta aatatacagc tcgcgagcgc atagccatgc
     2461 ttctcgacga aggcagtttc gaagaaatgg acatgttcgt agaacataga tgcaccaact
     2521 tcggcatgga aaagaaacac taccccggtg acggtgtagt aaccggttgc ggtacaatcg
     2581 aaggccgtct ggtttatatc ttcgcacagg acttcacagt ttctgccggt tcactgtccg
     2641 aaaccatgtc tctgaaaatc tgtaagatta tggaccaagc catgaaaatg ggtgctccgt
     2701 gtatcggtat caacgactcg ggcggtgcac gtattcagga aggtattaat gccttggctg
     2761 gctacgctga aatcttccaa cgtaacatac ttgcttcggg tgtcattccg cagatttccg
     2821 gtattttcgg tccttgtgcc ggtggcgccg tttactctcc tgccttgaca gactttactt
     2881 tgatgatgga aggtacatcc tacatgttcc ttaccggtcc gaaggtagta aagactgtaa
     2941 ccggagaaga cgtaagccag gaaaacctgg gtggcgcgag cgttcactcc accaaatctg
     3001 gtgttactca ttttactgca cagacagaag aagaaggttt ggctcttatc cgcaaactgt
     3061 tgagctacat tccccagaac aacctggaag aagctcccta tgtagactgt acagacccta
     3121 tcgaccgtct ggaagattcc ctgaacgaca tcattcctga taacccgaac aagccgtacg
     3181 atatgtacga ggtaattggt gctatcatag ataatggtga gttcctcgaa atccaaaaag
     3241 attattcaaa gaatatcatt attggtttcg cacgtttcaa cggacagtcc gtaggtattg
     3301 ttgccaacca gccgaagtat ctggcaggtg tgctcgacag caacgcatcc cgcaagggcg
     3361 cacgcttcgt ccgtttctgc gacgccttca atattcctat cgtatcattg gtagacgtac
     3421 cgggattcct tccgggaacc ggccaggagt acaacggcgt catcctgcac ggtgccaaac
     3481 tgctgtatgc atacggtgaa gctactgtac ccaaggttac catcacactg cgtaaatcct
     3541 acggtggttc gcacatcgtg atgagctgta agcagctgcg tggcgacatg aattatgctt
     3601 ggcctactgc tgaaatcgct gtaatgggtg gtgcaggtgc tgtagaagta ttatatgccc
     3661 gcgaagccaa agagcaggaa aatccggctc aattcctggc tgaaaaagag gctgaataca
     3721 ccaagttgtt tgccaatcct tataatgcag ctaaatatgg ctacattgat gatgttatcg
     3781 aaccgcgtaa cacacgtttc cgcatcattc gtgccctgca acagttgcaa accaagaaat
     3841 tgactaaccc ggctaagaag catggtaata ttcccttgta atcaagcttt tcacactaaa
     3901 acaagaacga ttatgaataa aacaaaaatc ggaatattcc tttcattgat gctggtgtta
     3961 ggcttttgct cttcttgcaa agaacagaaa tcgaacaaca aactgctgct gaatgaagtg
     4021 ctggtcaaca acgaaagcaa ctatcaggat gactacggtg tgcacagcgc atggattgaa
     4081 atattcaaca gatcatacgg cagcgccgac cttgcaggtt gctatctgaa attcagcagc
     4141 cagccgggtg atactgccag ttatttcatt cccaaaggtg acgttctgac actcataaaa
     4201 ccacgtcagc atgcactttt ctgggctgat ggagaaccaa gacgcggtac atttcatacg
     4261 aacttcaaac tggatgccac aaatgccaac tggattgggt tgtatgattc cggcaagaaa
     4321 ttgcttgatc aagtcatagt gcctgccggt actttaaaag ccaaccaatc ctatgcccgt
     4381 gtcagtgatg cagccgacca atgggaagta aagggtggaa gcgaagataa atatgtcact
     4441 ccgagtacca acaacaagac tatcgacagc aatgccaaaa tggaaaaatt cgaagagcat
     4501 gacagcgtag gtatcggtat ggctatttct gccatgagcg ttgtattctg cgggctgata
     4561 ttactctaca tctccttcaa gattataggt aaaatatcag ttaacctcag caaacgcaat
     4621 gccatgaaag ctaaaggtat tactgataaa caagaagcaa aagagaaaca actggggcag
     4681 gctccgggag aagtttttgc tgccatttca atggccatgc acgaattcca aagcgatgta
     4741 cacgatgtgg aagacacgat acttaccatt acccgtgtaa aacgcagtta ctcaccgtgg
     4801 agttcaaaga tttatacgtt gcgtgagact cctcacaaaa agtaagtcac ccataataaa
     4861 ataaaacgat gaaagaatat aaatataaaa ttaacggtaa cgtatataaa gttgccattg
     4921 gagatattga agacaacatc gctcatgtag aagtgaacgg tactccctac aaagttgaaa
     4981 tggaaaaagc accgaaggta gttgttaaac cggtagcacg tccggcagcc acatccgctc
     5041 ctgctgctcc tgctactccg gtagtaaaac cggccgctgc ttctaccggc aagtcaggtg
     5101 taaaatctcc gcttcccggt gtaatcctcg atatcaaagt aaatgtcggc gatacagtaa
     5161 agaagggaca agttatcatc attttggaag ccatgaagat ggaaaacaat atcaatgctg
     5221 ataaagacgg taagattaca gccatcaatg taaacaaagg ggactctgtt ctcgaaggta
     5281 ctgacctcgt aattattgaa taatatggga gaatttatca catttttagg aaacaacctt
     5341 gccgacttct ggacttatac aggttttgcc aatgcaacgg taggacatgt ggtaatgctt
     5401 ctggtaggtt tgtttttcat atacttggct gtagccaagg aatttgagcc gatgctatta
     5461 attcctatcg gtttcggtat gctgattggt aatatacctt tcaatatgga agccggatta
     5521 aaagtcggta tctatgaaga aggttccgta cttaatattc tgtaccaggg agtaacctcc
     5581 ggttggtacc cgccactcat attcctgggt atcggtgcca tgacggattt ctctgctttg
     5641 atatcgaacc ccaaattaat gttggttggt gcagcagccc aattcggtat attcggtgct
     5701 tatatgattg cccttgccat aggatttgac ccgatgcagg ctggtgcaat cggtatcatt
     5761 ggtggtgccg atggtccgac tgccatcttc ctctcttcca aactggctcc taacttaatg
     5821 ggtgccattg cggtatcagc ctattcatat atggcattag taccggtgat acagccgcct
     5881 attatgcgtt ggctgaccag taaaaatgaa cgtcttatcc gtatgaaacc tccccgtgtg
     5941 gtttcacata cggaaaaagt aatgttcccg attatcggtt tgttactaac cacattcctt
     6001 gtaccatccg gtctgccttt gctgggtatg ctgttcttcg gtaatttact gaaagaaagt
     6061 ggagttacac gtcgtctggc aaacacagcc agtggtccgc tgattgatac cattactatt
     6121 ctgcttggtt tgacagtagg tgcttctacg caagcatccg agttcttaac ccttgattca
     6181 atcaagatat tcggtctggg cgccttatca tttgtcattg ccacagcatc cggtgtcatc
     6241 ttcgtgaaga ttttcaacct cttcctgaag aaaggcaaca agattaatcc gttgatcggt
     6301 aatgccggtg tatctgccgt acccgactct gcacgtatct cccaagtagt aggtctggaa
     6361 tacgatccta ccaactatct gctgatgcat gccatgggcc cgaacgttgc cggtgtaatc
     6421 ggttccgctg tagcagcagg tatcctgctg ggattcttaa tgtaatacat ttattcattc
     6481 cgttatccgg cttgaattct gaactatttt agagcccctt catttttgga ggggcttttt
     6541 cgttaatcta tctaaaacag attacgatta tttcgtaaat acattctttt tagtaacttg
     6601 cagtcagttt aacctcatat aaatgatata ctgtatgcga aagcttttta tctccttatg
     6661 tttcagtgca tgctgttcgc ttctggcggc acagaccaca aatcccattc aagaggcgat
     6721 ggccaactac gattatgaaa cagccttgat gctgatcgat caagaaaccc cgaccgtccc
     6781 cctactctac caaaaaggga aagcgctgaa agggctgggc aataaccttg aagctctgag
     6841 cgtatttcag gaagtcgtag ctcaggattc tctcaatccc cgggcataca ttgaagctgc
     6901 cgaatgctgc aaatcacttg ccaaatatag cgaggcactg gattactacc aaaatgcgct
     6961 ccacataaat ccggacaata aatacgcacg catccagtat atcagtctgc tgatgaacat
     7021 gaagagatac cgtgagtctc taaaggaaag caacctgctg gcagaaaggg acagttccgc
     7081 ctatgtacta caccttagag ccgaaagtat ggggcaagtc tatgacaaca cagaaatcat
     7141 gcatgtgata gatgcctacc tggacataca gaaaagatat cccaatgatt acctgtctgc
     7201 tgccaaactc ggcaacatct atgtagcagg ccaccagtat gaagacgcca taaacataac
     7261 ggagaaatac cgttccatag actccaccaa cgtccttgtg aaccgcatca atgcccaagc
     7321 ctattgcctg aacaaagatt accccaaagc aatagaaaga tatgaacaac tgttacagga
     7381 aaaagacagt tctttccaaa cctgcttcta cgccggaatc agctattatg ccctcgaaga
     7441 cttctaccca gcacacgacc tgctggaaag ggctcttaaa gatgacaata ccaacatcaa
     7501 cgttctctat tatctgggac gcgcctgctc caagacatca tggaaagagg atggagtgac
     7561 ttatctggaa actgccgtaa gcctcgccat gcccagcgac agtgtcatgt cccgcctata
     7621 tgtggggctt gcggactgct acaagatggc atttcaatac accgaccagg cgaataccct
     7681 tctgacgcaa tacgaaaaat acgaccggca gaaacacaaa ctgctctacg acgcagcctt
     7741 tatctattat tactatctga aagatgcgtc caaagcagag agatacctaa cggcctacct
     7801 gaaaacccgt ccgaaaaaca gcaaggacaa agtgcaggaa gtagatgcgg acggagttcc
     7861 catcatcgga gaagacaacc gatacaatgc cgccgaaaac tggctgaagg acatcagaga
     7921 aaagcgcaag aaagaggact tcttcaaggg aaaggtcgat accgccagcg taacccccat
     7981 caaatagccc caatgaaaac gtttgcataa tataataagg tacagtaacg gagaaagatt
     8041 aactttctcc gttatttgtt ttaaattagc gcaaaaatta accgtaaagt tactatcatg
     8101 aaaaaagtat tcttaatctt gggaacactc ttactctccc tcagtacgta tgcagctatg
     8161 aatgtgaaca aaatcgaccc tccgttttgg tacaccggca tgcagaaccc ggaactccag
     8221 ctgatggtct atggcgaagg catcggcaac gcggcagtat ccgtcaatta tcccggcgtc
     8281 tcattgagca gcaccgtcaa gctggaaagc aacaactacc tcctggtcta tctgaaactg
     8341 gacaaggatg taaaacccgg caaattcaac ctcaccttca ctgaaggaaa aaagaaactc
     8401 gtaaaggaat atgaactgaa ggcacgcaac aagaaaggtt gcgaacataa aggtttcgac
     8461 gcctccgacg cactgtacct gctgatgccc gaccgctttg ccaatggcaa cccggacaat
     8521 gaccagattg cgggcatggc cgagtacaag atagaccgca atgaccccaa tgcacgccac
     8581 ggcggtgacc ttgccggcat cgaacaacac ctggactact tctccaacct cggcgtcaca
     8641 gccctctggt ttactccggt actggaaaac aacatgaccg gcggttccta tcacggctat
     8701 gccaccacag actactacaa ggtagacccg cgcttcggta ccaacgaaga atacaagcaa
     8761 ctgattgaaa aagcccatgc acgcggcatc aaaatcgtaa tggacatgat tttcaaccac
     8821 tgcggcgtag agcatgtatg gattaaggac atgccctcca aagattggtt caacaacccc
     8881 gaccacgaaa acaacttcgt gcagacctcc ttcaaactga ccccgcacgt agacccttat
     8941 acttcccagt acgatgccga ccagatgaac gacggctggt ttgtaccttc catgcccgac
     9001 ctcaaccaga agaatcctca cgtttaccgc tacctggtac agaacagttt ctggtggatt
     9061 gaattcgcca acatcgacgg catccgcatg gacacttacc cgtatgccga ctatgatgcc
     9121 atgagcaact ggatgaaaga gctcagcgaa gaatatccca actacaacac cgtgggcgag
     9181 acctgggtta ccgaacccgc ctacaccgcc tggtggcaga aggattccaa gctatcagcc
     9241 cccaagaaca gtaacctcaa gaccgttatg gacttcagct tcttcgacaa gataaacacc
     9301 gccaagaatg aacagaccga aacttggttc aagggactgg accgcatata caataacttc
     9361 gtatacgact tcctctaccc caaccccgct tccgtactgg cattcatcga aaaccacgac
     9421 accgaccgct tcctgggcga aggcaacaac cttccgatgc tgaagcaagc ctctaccctg
     9481 ctgcttacca cccgccgcat tccgcaactc tactacggaa cggaagtcat gatgaatggc
     9541 gtgaagagca agagcgacgg ctatgtccgc aaggacttcc ccggcggatg gaccggtgac
     9601 gcaacaaacg cactgacccc agccggacgt accaaaatac agaacgagtg ctacgacttc
     9661 tacaagacca tcctaaactg gcgcaaagga aacgatgtga ttgccaaagg cagcatggtg
     9721 cagttcatgg tacagaatgg tgtttatgcc tacgcacgcc agtacgaagg caagacgata
     9781 ttcgtgatgc tgaacggtac agatgcagag accaccgttc ctttgaaatt ctacaaggaa
     9841 atcctaaaag acagcaagca gggaaaagat attcttagcg gcaaggccat caccttcggt
     9901 gaagagctga agatgggccc cagagaatca ttagtgatag aattataacg cgcactccac
     9961 acagagagct cattcttgca aatctccctt gcagatagct tgcagacacc tcgcctgcca
    10021 gccatctgca agggattttt agtatggaat aggtgtcacg gggatatgct tttcaccggt
    10081 ctcaaatata gctaatctgt tagttcataa cggtgaacac tttgttccag tatagagaaa
    10141 caaagtgttc ggatatgtag aaacaaagtg ttcttacgta ttggaacgaa gtgtttttgc
    10201 atattggaac gaagtgttct ctttattgaa acaaactgtt cagttaaggg aaacagactg
    10261 ttttgttaaa ggaaacagac tgttgtacac gttgaaacat ccgcttctga aataaccggc
    10321 gaacttaacc atcccacaac accggcctat atataacaag tcagcccttg caacatcaat
    10381 attgcaaggg ctgacgctat attcggatta tctttcgatt agtccagttg agccaatttg
    10441 ttctctgaac caagcacgtt gatgatttta tgcttgtaca gtttttccat attgtcacga
    10501 gccggaccca gatacttacg cgggtcgaat tctgccggtt tttcagcaaa tgtcttgcgg
    10561 atagcagctg tcatagccag acgtgagtca gagtcgatgt tgattttgca aacagcagac
    10621 ttggcagcct tacgcaactg ctcttcgggg ataccgatag cagcttccag cttaccacca
    10681 tacttgttga tagtatcaac ttcttcctga ggaactgaag aagaaccgtg aagaacgatg
    10741 gggaatcccg gaagtttctc cattacagca tccagaacgg caaattccaa aggaggagga
    10801 accagacgac cggtagcagg gtcaacgtgg cattgttcgg gtttgaactt gtatgcacca
    10861 tgagaagtac cgattgagat agccagtgaa tcgcaacctg tacgggtagc gaagtcaata
    10921 acttcttcag gattagtata tgtatggtgt tctgcagaaa cttcatcttc tacaccggcc
    10981 aatacaccga gttcgccttc tacagttacg tcgaactgat gggcatagtc aactaccttc
    11041 ttagtcagtg caacgttttc ttcgtacgga aggtgtgaac cgtcaatcat tactgaagag
    11101 aaaccggagt cgatacagct cttgcaagtt tcgaatgtat ctccgtggtc aaggtgaaga
    11161 acaatttcag gatgtttgca acccaattcc ttagcgtact caacagcacc ctgagccatg
    11221 taacgcaaca gcgtagcgtt ggcatactga cgggcaccct tagatacctg aagaataacc
    11281 ggagactttg tttcaactgc agccttgatg atagcctgca tctgttccat attgttgaag
    11341 ttgaatgccg gaatagcata tccacctttg atagccttag caaacatctc tcttgtgttt
    11401 accagtccta aatctttgta attaaccatt ttgtttaaat tttattgtta gtgaattaaa
    11461 attctacgca aaagtaatca ttatccttta aagtaaagaa cttgacggga ataaaatatc
    11521 cggctcatcc taccaaatcc attctatttt aaagctattg gcttcattta acagattatt
    11581 gtaatctcta tattacaaac tctttgcatt tatctctgcc agccatactt ttgccatcta
    11641 tacttctatc aacaaaaaag ccggagaaca tgtttgctct ccggcatctg tttacacatt
    11701 attatgtaat actaattttt cagatagatg atggtcggca aatggtcact gtaaccgttc
    11761 agccaagtcc tgcccccatg cgtacgcaag ggggaacctt tgtatttgcc atcctgctga
    11821 atcagataat cgcggatgaa aacttcattg tgatcatagc gcaacccttt cttagccttc
    11881 agcaacggtt tcgaaatgac aatctggtca aacaagttcc acttgccccg atagagcaat
    11941 gtccccactc ccttgtcttc cagcgtcacc caccagggat tgtagaattc gcctttcttc
    12001 acctgcttcg gatatttgcg cgctcccagc acctccatgc tttcgtccat cgggtcgtca
    12061 ttcatatccc ccatcacgat gagcttcagc ttcttgtcgc tacgcatcag agagtccttc
    12121 aaggccttta cctgcctggc tgcatgcaca cgcaccggcg actttgcccc acgggagggc
    12181 cagtggttca ctatcacgca gacacgctct cccgccagtt gtccgtccac aatcaagaag
    12241 ccacgcgtca agtgcaccgt atccccctca aaaggagtgg aaagcaccaa ctttgagtgg
    12301 gtaacgctga attgcttcgg gtcgtacagc aaggcacagt cgatgccccg tctgtccggt
    12361 ccttcataat gcacgaactc ataattggaa atggccggct gcttcacgag gtcttccagc
    12421 acccggctgt tctctgcctc tgccacaccg atgaatgccg gaccttccgg cactaaatca
    12481 cgcgaaaggg accccaacac tttggaaagg ttctgcagct tggactcata cttctttgcc
    12541 gtccactggt aactgccgtt aggcaggaac tcatagtcat tcttacctgc atcatgaatc
    12601 gtatcaaata agttctcaag attgtagaac gcaacactat acagtttccg ttccgcattt
    12661 tgtgccccca gcgttgccac gcacagccag aaagagcata agacaagtag tttcctcata
    12721 aattcacaag attaagtcct gcaaaaatca gaaataaaat gcgataaacc tactaaataa
    12781 aaataaatct gaatttattt tgtagagtct ccaacttgca ctatctttgc gctctgaaaa
    12841 gaagaccatt acactattta ttaccaaaat agtaacagaa tataaatttt taaaagaaaa
    12901 tatcaaaatg aaaaaaggta ttcatcctga aaattaccgt ccggtagtat ttaaagatat
    12961 gtcaaatggt gatgtattct tgtctcgttc cacttgcaac acgaaagaga ctatcgaatt
    13021 cgaaggtgaa acttatccgc tggtaaagct ggaaatctcc agcacttctc acccgttcta
    13081 cactggtaag tccaagctgg ttgacaccgc cggtcgtgtt gataagttca tgagccgtta
    13141 cggtaaccgt aagaaataat cagtttcaag caaactgaaa aaagggagtc tttcactgaa
    13201 aggttccctt ttttgtttcc gcctcccgct gagcgataaa tagggaatct cctatcacag
    13261 aataggggaa aaaacaagaa aggggaaaaa cactttccta tttttgtatc atcgaaaccg
    13321 aaaacatacc ataatcatga aacgactcgc caccctattc atcctaacaa tccttgtcac
    13381 aacggcaggg tttgccaaac ccaagcacaa ggacttaagc ggaaacatcg ccatcaaagg
    13441 agaattgaca aaagagtacc agcaatctcc cgccggtacc ccggtcatta tccgccgggt
    13501 tgtcaaaatg aacaatcccg gtgaaaacag cgataacatt tactatgccg tcgaagtgaa
    13561 tggcatacaa gaaaccattc cttcggatga gatgggtatc attgccatat ccgctccgga
    13621 aacggaccgg gaattctggc agcaaatata cctgaagaat catctttacg aatatttcaa
    13681 cgaccgcggt tacaagcaca aactgcgcca ggaaatcgac gaagaatgcc tggactatct
    13741 cgataaactg aacgagatag cctatcagga cgactacata acctcgtacg tacaaggaat
    13801 attctccaaa ctgaatgcca ccaccattga cagcaatcgt ggagaaagcc tgaacatacg
    13861 tatcatccag tcgtccgaac cagatgcctt catgctttcc aacggctcca tggttatcag
    13921 tacaggcctc ctctgcactc ttgattccga agacgaactg gccgccgtca tcgcatgtga
    13981 gctgggacat ttcgtcctcg accatcaggt aaacaacatt tatcgtgccg agcggcgtgc
    14041 caagcgtgca gctttttggg cagatgtctt tgccactacc gccagcgcag ccctcgatgt
    14101 ggcctactgg gacgataatg aagatgctta tgccgtcagt ctggtggcag atatcggagc
    14161 catcgcttcc cttttgagca ttccggcaac ggaccggttg gggatgaaat acaaaacttc
    14221 ccaggaaatc tcttcagacc gccttgcgcg ccaacttctg gcattcaagg gctataatcc
    14281 cgacggaatc gcatcggccc tcggtaaaat tatagggtat tacaacctgc accaacgcaa
    14341 caaggacatt cctcgctacg gcagcatcgg caacctgcaa aagcgtatag aaaaggccgg
    14401 tgaatcccat agcctgagtg cccgccccta cctacggacc accagcgatg tcgtttcttt
    14461 caacgcaagt atgaactacg ccaacaagcg ctataaggaa actgcccggc tgatacgcaa
    14521 gaacattgac aacagactag ccacggacaa tgactacatc atcctggtaa aagcggaaat
    14581 ggcactgtct aatacggaag aagtgaacaa ccgctgcctc gccatgcttg ataaagccca
    14641 ggagatggca ggaacaagcc ccaatctgga catatataaa caaaaaatac tattattgat
    14701 gcgcatgaac aaacaagccc aagccgctga tatactgaaa gaatatatca ccttgctttc
    14761 ggcctacgaa ggccagggct tagaaggaac cgaaaaggaa tggaccaata aagagatagg
    14821 ttgggcaaac caaatgctgg acaggataag cagaatatag agaaaggaat aactaagaat
    14881 gaagaatgaa gaatttgtca tgcggcatca ttgcgcagcc aaattcttca ttctcagtca
    14941 tttattcaaa ctactgtttg cggaacggcg gcttcacaac cacagctttc agcttacgtc
    15001 cccgcatgtc aatgcagatt tccgtaccga ccttgctgta ttcgggtctg atatacccca
    15061 ttccgatacc aatcttacgg gtaggcgaca tagttccgga ggtaaccaca ccgatggcaa
    15121 taccgtctgt actatacagc tcgtaaccat gacgggggat accgcggtct atcatctcaa
    15181 atcccaccaa cttacgggta gtgccttccg ctttctgttt ttccagcatc gggcgattgg
    15241 tgaagttctt tccctccaca aacttggtaa tccatcctaa acccgcttca atgggcgaag
    15301 tggtgtcatc caaatcattg ccatacaaac agaatcccat ttccagacga agcgtatcgc
    15361 gcgcacccag accaactggc ttaatgccga actccgcgcc tgcctcgaac acggcatccc
    15421 aaatcttcat ggcagcctcc ggatagaagt aaagttcaaa accacccgcg ccggtatatc
    15481 cggtattgga gataatgaca tccttttctc cggcaaactc accgtgggta aaagtatagt
    15541 aaggaaggtc ggaaagatta atggaagtca gcttctgcaa agcctgaata gccttcggtc
    15601 cttgcacagc aagctgtgcc atgtgctcgg aagcattttc caattcagcg ccttccgtgt
    15661 tatgagacac acaccagttc cagtctttct caatgttcga cgcattcacg acaagcaggt
    15721 atttctccgg ctcataatga tagaccagaa ggtcgtccac aatgcctcca ttttcatttg
    15781 ggaagcaggt atactgtact ttccccggtg tgagggcagc tatgttattg gaagtcactt
    15841 tctgcagaaa gtccaaagca tggggacctt tcacccaaaa ttctcccatg tgtgagacgt
    15901 cgaatacacc gacaccctga catactgtaa gatgctcgtc aatgatgccg gaatactcga
    15961 taggcatatt atatcccgca aactcgtgca tcttggcacc cagcgagatg tgtttttcgg
    16021 taaacggagt ggttttcatg gaactattag agttatgagt tatgaattat ctatttgctt
    16081 gctacgagct cggcaatctt gacgatgacg ttcatggctt tctccatgtt ctggataggc
    16141 acgaactcat agcggccgtg gaagttcaag ccaccggcaa agatattggg acaaggcagg
    16201 cccttgaaag agagctgggc gccgtccgta cctccgcgaa tggcttttac acgaggctct
    16261 acacctaccg ccttcatggc ggcaaaagcg g
//
