LOCUS       gnlProkkaNNOIHIKA_48   12293 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NNOIHIKA_48.
ACCESSION   gnlProkkaNNOIHIKA_48
VERSION     gnlProkkaNNOIHIKA_48
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:53:25
            Original ID  :: gnl|Prokka|NNOIHIKA_48
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12293
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12293
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3401:7754]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3402..7754
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12293
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12293
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             33..251
                     /locus_tag="ctg48_1"
                     /transl_table=11
                     /translation="MDSFVIRTYGRTELAQIYCPNLCPEAAFRKLKHWIDLCPDLRDGL
                     SALGGSSRSRSYTPAQVRLIVAALGEP"
     CDS             complement(376..2151)
                     /locus_tag="ctg48_2"
                     /transl_table=11
                     /translation="MEPLSSLHLLAEAVRNAGADIAPTYQEYIQLAFAIATDCGEAGRH
                     DFLSLCSLSSKYDRRAADKLFSNALKTGRNDVHLGTAFHLAELCGVKIQHEAAPAIGTL
                     GTQSSPLSSTSHTRAREEESASGIEPLSPLPTFDEHLHWPYPLNRIMSCGTSLAQYDVL
                     LLGAITVLGASMGKHVRCSYGGKMMSPCLQTFVVALPASGKGVLSLVRLLAEPIHDEIR
                     GQVDESMACYRREKAKYDTLGKERGKTETPVMPLNKMFLISGNNTGTGILQNLMDSDGT
                     GLICESEADTISTAIGSEYGHWSDTMRKAFDHDRLSYNRRTDHEYREVKKTYLSVLLSG
                     TPSQVKPLIPTAENGLFSRQVFYYMPAIHHWQNQFDRNDSDLEDTFKALGMEWKDKLKT
                     IVMNGIFTLHLTDGQKDEFNRLFSRLFVRSGLANGNEMSSSVARLAINICRIMEVVAML
                     RAMEQGEITASPYVSPDPHTATDNLKDHIVSRWNLLIASDDFHAVLSLAESLYRHTTHI
                     LSFLPNTEVTSRGNADRDALVDSMEEEFTRASFLQKAGEMGIKSETASTWLKRMQKHGL
                     VENVDGKGNYRKPKV"
     CDS             complement(2203..2805)
                     /locus_tag="ctg48_3"
                     /transl_table=11
                     /translation="MPPISPMKDGATRKIVKSATLTPLRTLELNEVYQLITANKRLITL
                     TQAIREAALQGDDNNCRMLKQQTLPYVTPCGVFTRRRSDCLKLPSGLVVVDVDHLDSPD
                     EAGRLKQLLFKDPYLAPVLVFISPTGRGVKAFVPCPIGKDSTEAVRWAMNYVHCMYDAE
                     NTQPGKGVDTSGKDLVRACFLCHDPKALLRKVVNFEL"
     CDS             3304..3405
                     /locus_tag="ctg48_4"
                     /transl_table=11
                     /translation="MINFTVGPVQSSDAVRVIGAEQVPYLEQQSFQK"
     CDS             3402..4154
                     /NRPS_PKS="Domain: Aminotran_5 (3-189). E-value: 1.1e-20.
                     Score: 65.7. Matches aSDomain:
                     nrpspksdomains_ctg48_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_5"
                     /sec_met_domain="Aminotran_5 (E-value: 1.4e-18, bitscore:
                     57.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDK
                     ALVINGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETF
                     TGVHYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIA
                     VMLLAPSAIKRIEKVQCCCQYLDLKLALKNMERGQTPCTPAVGILRQINVRLKEIESAG
                     GAEVEIARCAELAKYFRDKLVKNNLPLF"
     aSDomain        3411..3968
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_5_Aminotran_5.1"
                     /evalue="1.10E-20"
                     /label="ctg48_5_Aminotran_5.1"
                     /locus_tag="ctg48_5"
                     /protein_end="189"
                     /protein_start="3"
                     /score="65.7"
                     /tool="antismash"
                     /translation="ENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDKALV
                     INGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETFTGV
                     HYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIAVML
                     LAPSAIKRIEKVQCCCQYLDLKL"
     CDS             4151..4525
                     /locus_tag="ctg48_6"
                     /transl_table=11
                     /translation="MTYRQVGTNSFTVKYYVEKFILDMNTMKIIRVDEYRDKKKINRPA
                     GSLFSVDGEIYRVAQKCSRAYGESIFVYKTSKNFDFIKDKKVAELTGQSIVLSDGRKPI
                     LLHTYSQAGGIEVIDYRCSL"
     CDS             4550..5860
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_7"
                     /sec_met_domain="CTP_transf_like (E-value: 1.6e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.9e-114, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-61, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             5895..7022
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_8"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.2e-24, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             7026..7754
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_9"
                     /sec_met_domain="Metallophos_2 (E-value: 6.2e-28, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             7755..8750
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg48_10_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_10"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.3e-09,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.6e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        8004..8348
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_10_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg48_10_NAD_binding_4.1"
                     /locus_tag="ctg48_10"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             8747..9487
                     /locus_tag="ctg48_11"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKIELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             9496..9912
                     /locus_tag="ctg48_12"
                     /transl_table=11
                     /translation="MAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSIIYI
                     FHMPLFVFISGYYANVKDKEKLISKGFMLLETFLVVMIPQCFYYGSIIPLLNPENSGWY
                     LISLITWYIIFLLIINKLVGKIVVQYNGCGGGSY"
     CDS             9891..10505
                     /locus_tag="ctg48_13"
                     /transl_table=11
                     /translation="MRGGQLLIFSCLLAVFAYMLPLKQFGNLLSFQRSCMFLPFFMMGF
                     LRRVKGLPIIPDVSKCIKLVLAIASLVCFAFCLIYSGRILHVLEFNNANVWHMSNLYNQ
                     NIGMLLVLKVLVYIGSIITTFAVLMFVNLPKSICAYGSKTLAYYVIQGMFAHILSTYLQ
                     VNFYQALFLCVCILILTTVLLRFVDSKFITNPFSTLLKWKY"
     CDS             10562..11680
                     /locus_tag="ctg48_14"
                     /transl_table=11
                     /translation="MIIGLGSVGCYLLDYLVSLGDSQLRLVVVGRNAEKMQMDINIIRT
                     ASTIRHQCRSEIKVVDNCDLNDVNSIAAVLEAEKPDFIVNSSRVYSGLKYGSISWSNLR
                     AYGIWTPLSIRYAKNIMEAYDKANCEAISINTSYSDAVIPWLKSAGKAYFDFGSGNLNH
                     LVPRIKFYIAEKYGIKNFNDIDVTIAVSHFHDVVISKEGHAEGQDILLDIKFQGKDMDF
                     NKEELLKSCSIAMPVDQKRNMMNASSNFDIIFSVLTALREEKQVKIHTPGVNGEIGGYP
                     IIIDGVTATAKFDESVWTIDQMRKANRESIYCDGVENITDATLVYTDELVAKVKKSFNV
                     DLPKSVKFVDIENVADLIINQIIKPQVLIFVQ"
     CDS             11828..11977
                     /locus_tag="ctg48_15"
                     /transl_table=11
                     /translation="MYSSEDLASFYFQYQTKALPHVKFLQSFCMKHKVPIIFFISGIRI
                     RVIK"
     CDS             12023..12265
                     /locus_tag="ctg48_16"
                     /transl_table=11
                     /translation="MDITTKIKRSKLLYYVYYYVMSGLVNLYKLFLKPDGKLMLFVCYG
                     GRHYSDSTRVIYEAMLKDERFKDYIGLRQTDCCIY"
ORIGIN
        1 tttttatgaa atataaatcg taactgtcaa ctatggattc ttttgtcata cgtacatacg
       61 ggcgtaccga attggcccaa atctattgtc ccaatctttg tccggaggct gccttccgca
      121 aactgaaaca ctggatagac ctttgtcccg atttgcgtga cggactttcc gctttgggcg
      181 gttcttcccg ttcccgctct tatacgcctg cccaagtgcg gctgatagtg gctgcacttg
      241 gagagcctta aacctgaggt tggatggcgt aaaggtcagg ccgggaatcg taaaggtgag
      301 gttggtacac ttggtacaga ggttcatcca tcctttcgcc tcacacacat acgcgtgcgt
      361 gaagcgaagt gaatgtcaga cttttggttt ccggtagttt cccttgccat ctacattttc
      421 caccagcccg tgtttctgca tacgtttgag ccaggtggag gcggtttccg atttgatgcc
      481 catctctccg gctttctgca ggaaagaggc ccgtgtgaat tcttcttcca tgctgtctac
      541 cagtgcatcc cggtcggcat tgccgcggct tgtcacttcg gtgttgggca ggaaggagag
      601 gatatgggtg gtatgccgat aaaggctttc ggccagtgag agtacggcat gaaagtcatc
      661 ggaagcaata aggagattcc atcggctgac aatgtggtct ttcagattgt ctgtggctgt
      721 gtgagggtcg ggcgacacgt aaggcgaggc ggtgatttcc ccttgttcca ttgcgcggag
      781 catggccacc acttccatga tgcggcagat gttgatggcc agacgtgcca cgctgcttga
      841 catctcgttt ccgttggcta gtccggagcg tacgaaaagc cgggagaaga gccggttgaa
      901 ttcatctttc tgtccgtccg taaggtgaag ggtgaatatt ccgttcatga caatggtttt
      961 cagtttgtcc ttccattcca tgcccagagc cttgaaggta tcttcaagat cgctgtcatt
     1021 gcggtcgaac tggttttgcc aatgatgtat ggcaggcatg tagtagaata cctggcgaga
     1081 aaagagcccg ttctcagcag tgggaatcag tggtttcact tgtgaggggg tgcctgacag
     1141 aagtacggaa agataagttt tctttacctc tcggtattcg tggtcggtgc gccggttgta
     1201 ggacagtcgg tcgtggtcga aggctttgcg catggtgtcg ctccagtgtc cgtattccga
     1261 accgatggcg gtggagatgg tgtcggcttc gctttcgcat atcagtccgg taccgtcgga
     1321 gtccatcagg ttttgcagga tgccggttcc ggtgttgttg cccgagatga ggaacatctt
     1381 gttgagaggc attacgggag tctccgtttt tccacgttcc ttgcccagtg tgtcgtattt
     1441 tgctttttcg cggcggtaac atgccatgct ttcgtctacc tgcccacgta tttcatcgtg
     1501 aatgggctcg gcaagcaggc gtaccaagga gagcactcct ttgccggatg caggtagggc
     1561 tactacaaag gtttgcaggc agggggacat catttttcct ccgtaggaac atcggacgtg
     1621 ttttcccata ctggcaccca atacggtgat ggcacccagt agcagtacat cgtattgggc
     1681 gagggaggtt ccgcagctca tgatgcgatt caggggataa ggccagtgga ggtgttcgtc
     1741 gaaagtgggt aatggagaca gtggttcaat gcccgatgcg gactcttcct cgcgtgcgcg
     1801 tgtgtgtgag gtagaagaga ggggtgaact ttgtgtacca agtgtaccaa tggcgggtgc
     1861 ggcttcatgc tgaatcttca cgccgcaaag ctcggccaga tgaaaggcgg ttcctagatg
     1921 cacgtcgtta cggccggtct tcaaggcatt gctgaagagc ttgtcggctg cccgtcggtc
     1981 gtacttggac gacaggctgc acagacttaa aaaatcatgc cgtcctgctt ctccgcagtc
     2041 ggtggcaatg gcaaatgcca gttgtatata ttcttgatag gttggagcaa tgtctgctcc
     2101 tgcatttctg actgcttcgg ccagaaggtg caatgaagat agtggttcca tcggatttgg
     2161 taatttataa ttagtaattt gtagtcggtg atttgcaatg actcataatt cgaagttcac
     2221 aacttttctg agcagtgctt tcgggtcatg gcagaggaaa caggcgcgta cgaggtcttt
     2281 ccccgaagtg tccactcctt ttccgggttg tgtgttttct gcgtcataca tgcagtggac
     2341 gtagttcatg gcccagcgca ccgcctccgt gctgtctttt ccgatagggc agggtacaaa
     2401 agcctttaca cctcgtccgg tagggctgat gaacaccagt accggtgcga ggtaagggtc
     2461 tttgaacagt agttgcttca ggcgtccggc ttcgtcaggt gagtcgagat ggtctacgtc
     2521 caccaccacc agtccggagg gtagctttag gcagtcgctc cgtcgtcggg tgaatacgcc
     2581 gcagggggtg acgtagggta aggtttgctg tttcagcatc cggcagttgt tatcatcgcc
     2641 ttgtagggca gcttcgcgga tggcttgtgt tagggtgatc agccgtttgt tggctgtgat
     2701 gagttggtaa acttcgttca gttctaaagt acgcaggggg gtaagcgtgg cgcttttcac
     2761 gattttcctg gtcgctccgt ccttcatcgg tgagatgggt ggcatgaaaa gcgacatttt
     2821 aaaagatttt ggcatattat acgtttaaat agttggctca aaggtattca ttctctttcg
     2881 ttgaatcttt cccacatgta agaaagattt taaaggaaca aagtaaataa taacaatata
     2941 taacataata ttctatctaa ttacttaaaa tttatctaaa tgggcaaaaa ttttattcac
     3001 ccttcattgg gcttttttat cgagcgaacg agaaaacaga gtggagtcac tattgaaact
     3061 ctttgcaagg atttgcatat ttctccatcc acgtacatag acttaaaaaa aagggtgtaa
     3121 cgcctcactt agtacatacg aaactcttct gcgatactat atcgatgaac tggaggaact
     3181 ggatgatgac gaaatcagga aattggctgg ggaatgggtg gaaaaatggc tggaggttag
     3241 gaagaagggg gagtggtgat tggattggtt gattattact gataattaaa ggaatctata
     3301 taaatgatta attttacagt aggtccggtg caatcttctg atgctgtacg ggtcataggt
     3361 gccgaacagg taccatattt agaacagcag agttttcaga aatgatgctt gagaatgagc
     3421 gccttgttaa gaaatttgct aatgcgacta aagatagtaa ggttgttttc atgacatgtt
     3481 ctggctctgg tggtatggag gctgccatca taaattgcct tacgccacag gataaggctc
     3541 ttgtaatcaa tggtggtagc tttggtgagc gttttgtgga attgcttacc cttcataaaa
     3601 ttccttttac ggaaattaag cttaagtatg gtagagcttt gaagcctgaa catcttgctg
     3661 aatatgagag caagggttac actactttcc ttatgcagaa gcacgaaact tttacggggg
     3721 tacattacga tatcaatctt gtttctgatt tttgcaaacg taataattgt ttcttgattg
     3781 ttgatataat ctctaccttc ctttgcgatt catttgatat ggtggcaatg gatgtagggg
     3841 tgatgattac tggaagtcag aaggctcttg cttgcgctcc gggtattgca gttatgcttc
     3901 ttgctccttc ggctattaaa cgtatagaaa aggtccaatg ttgctgtcag tatcttgatt
     3961 tgaagcttgc tcttaaaaat atggagagag ggcagactcc ttgtactcct gctgttggta
     4021 tccttcgtca aattaatgtc cgtttaaaag aaattgagtc tgcaggtggt gcggaggtgg
     4081 agattgcgcg ttgtgcagaa ttggctaagt attttcgtga taagcttgtt aagaataatc
     4141 ttccactctt ttgacttatc gtcaggttgg aacaaatagc tttacagtta agtattatgt
     4201 tgagaagttt attcttgaca tgaatacgat gaagataatt agggttgacg agtatcgcga
     4261 caaaaagaag attaatcgtc ccgcaggttc gttattctct gtagatggag aaatttatcg
     4321 agtggcacaa aaatgcagtc gtgcatatgg agagtcgatc tttgtgtata agacaagtaa
     4381 gaattttgat tttattaaag ataaaaaggt agcagaactc actggtcaga gtatagtcct
     4441 gagtgatggt agaaagccga ttttgttgca cacttattct caagcaggag ggattgaggt
     4501 gattgactat agatgctctt tataataatt tgaaaaatgt taaataataa tggcaaagac
     4561 agtttatctt ggtatgatag gtgatatcat gcatccgggt tacattaaca tcattaacaa
     4621 agctactgag tatggcgatg tgataatcgg tttgttcact gataaggcga ttgctaacca
     4681 ccgtagactt ccttatctca cttgggagca aagaaagaac gttgttgaga gcatcaggaa
     4741 cgtatcaagg gtggtccctc aggatgattg gagctatgtc tctaatctcc ttaagtacaa
     4801 gcctgattac atcattcatg gtgatgattg gcaggtgggt cctgacaagt atatccgtga
     4861 tgaggtattc aaagtaatgg aaaagttggg tggtgaggtt atcgagattc cttacaccca
     4921 aaacatctct gcttctggta tcaaacaaga gattgatgct cttggtgtaa ctcctcagat
     4981 gcgtctttct tctctccgtc gccttattgc agctaaaccg attgtacgta ttcttgaaag
     5041 tcacaatggt cttactggcc tcatagcaga acatactaag gtagaggtga atggtcagga
     5101 gcgtgaattc gatggcatgt gggcttcctc ccttaccgac tctacctcta agggtaagcc
     5161 tgatattgag gctgtcgatt tgactacccg tctccatgac ctcaatgata cccttgaagt
     5221 aaccacaaaa cctgttatct tcgatggcga tactggtggc aagattgaac acttcggttt
     5281 taccgttcgc acccttgagc gcttgggaat ctcttgcgtt ataattgaag ataaggtagg
     5341 tttaaaacag aattcacttt ttggtactga tgctgtacag actcaggata caatcgaagg
     5401 ttttcaggct aaaattcgtg caggtaagga agcgcaaatt actcgtgact tcatgattgt
     5461 cagccgttgt gagtctctca ttgctggtaa gactgtagat gatgctttgg agcgttgtca
     5521 tgcttacgta gaggcaggta ctgacggtat aatgatccac tccaaagaga agtctggaga
     5581 ggacatcaag gagttttgct tgcgctttcg cgagaagaat gctcatactc ctatcatcgt
     5641 tgtgcctact acttataacc agttcacaga agaggaactt gctgaatggg gtattaatgt
     5701 agtgatttat gctaatcaca tgcttcgttc tgcttatcct gcaatggtta aatgtgcaga
     5761 aaccatcctc tatactagcc gttcgcttga agcatctgag cagtactgta tgcctatcaa
     5821 acagattctt aatcttattc caggcacaaa gaagaagtaa acattaattt cttacccctt
     5881 aaactatttt acaaatggta agacccgaat tttttgtaaa tatactcaag gaacaaggta
     5941 tagactttta tgctggtgtt cctgattcgt tgctcaagaa catttgtgca tatattaccg
     6001 accaccttcc tgctgagcag aatattattg ctgctaacga aggaggggcc atgggtattg
     6061 ctgtaggtta tcatttggca acaggtaagg tgcctgtagt ttatatgcag aactctggtg
     6121 aaggcaatat cattaatccg tttgcctctc ttaccgacaa ggacgtttat aacattcctg
     6181 tgctcctcgt tatcggttgg agagggcgcc ctggagttca cgatgaacct cagcatgtga
     6241 agcaaggtaa ggtgacaatc ggtttgctta ataccatggg tatcaactat gctattctgc
     6301 caaaggatga agagggagct gcaaagcaga taaaaatagc tgtcgacttc atgaaggcaa
     6361 ccaacgagtg ctatgccctt gtgatagaga aggatacttt cgatacctat aagcttcaga
     6421 gcgttgaggt aaacgaactg gcaatgtctc gcgaagagac gattcagaag gtggcttcaa
     6481 acattgaaga taatgcttgt atcgtatcaa ctactggtat gatttctcgc gagctctttg
     6541 aggcacgtac tgcttggagc caaggtcatg aacgtgattt ccttactgta ggggcgatgg
     6601 gccatgcttc ccagatagct ctcggcatag ctctccaaaa gcctgagcgt cgagtatatt
     6661 gttttgatgg tgatggagcc agcatcatgc acatgggtaa tatggctatt acagccagca
     6721 tgaaatgcaa gaattatgtg cacattgtgt tcaacaatgg cgcacacgat tctgttggtg
     6781 gtcagcctac tgttggtctc aagattgatt tttgtgcaat tgctcaagct gtaggctaca
     6841 aggctgctta tagtgtagaa actatggagg cacttgaagc aaaacttgca gaattcaaga
     6901 acgcagaagg tcctgttttc cttcagattt gcgtaaaaaa gggaaaccgc aaggaccttg
     6961 gccgtccaac tacaactcct attcagaaca aagaggcttt tatggaattt cttaacaagt
     7021 aaagtatgaa agtaattctg tttgctgata tacacgccaa tctttctgct tttgaggcgg
     7081 ttctagctga tattgagaaa cactatcagc cagatgccat gattagtcta ggtgacttta
     7141 tcgactatgg tatgcgttca aatgaaatta ttgaacgtat acaaactgtt aatattccat
     7201 tacttgccaa tttgaagggc aatcacgaga aggctttgat tgatggggaa ctctcatgtt
     7261 tctcttcaga aagagctcgt gtgatgtcca aatacacaag aaaccatctc actcagacat
     7321 ctattgatta tataagcaat gtgatgcaag agccaatgca agagttggaa attggtggta
     7381 agaaagtact tcttttacat ggaactattg atgatcccta ttggggaaaa ctgactccag
     7441 caaaagtgga agatgaaaag tatcaggatt ttgactacgt attgagcggt cacattcatc
     7501 aaccttttaa gatagatgta ttcttcaaag ttgacaatcc aatcatgcgc aatcagaaac
     7561 gtacgacttt tatcaaccca ggttcagttg gacaacctcg caatcagaat ccatatgcac
     7621 aatatgtgta tatcaatttt aaaacggggg aaacccattt caatgcagtt ccttacgata
     7681 ttgaagctga acaatctctt ttccccaaag agatagatac tttttacagc gaacgattaa
     7741 aatttggaat ataaatgaag aacttatatg taataagtgg tgttactggc atgacgggta
     7801 gtgaactgtc tcgtcagttt gtttctcagg gtcatacggt aatcggtttc gacaacttct
     7861 ttgcaagttc tattgatacc gttaaagaca ttattgacaa tccctcgttc atcttctata
     7921 attacgacat taacaaagtc gctcagatgg atgaagtatg cgataaggcg aaagaactca
     7981 aaattgagtg cgatggccgt ctggtgttta tcaattgtgc tgctgttgtc catacaaagc
     8041 atttctatga ggtagagagt acttttcaga ctaacgtcct tgctatgaag gatttcttgg
     8101 agcgtgccat ttctatgagg gctgatactt acattaattg ttcaacttcg gaggtttact
     8161 caatgcagtc ttggaatgag aatggcggtg tgaaagaatc tgattatttg gcaatgtcaa
     8221 cagcggaaca tagccaacgt acaagttatg cttgcggcaa gttgatgact gaattcttta
     8281 tgaaagatgc tgttggcaag ggacgaatta aaggttgttc tattcgcttt gctaatgtat
     8341 atagcaggca cgagcgtttt gcagagcaca ttatccctca tatcattgat aatctgcttg
     8401 aaagccatac cgtaaccctt cttgaaaact cgaaggtgaa caaacgtacc ttccttcata
     8461 atattgatag ctgtcgtgcc gttatggagc tcatcgcttc tgaggatgct cttgatggta
     8521 ctgtttataa tgtggctact gaagaggaaa ttgccattat tgatctagtc aagacgattg
     8581 caataaaaat gggcatcaac gatgtggata tccgtttcga aggttaccga aagtctgatc
     8641 ctgagcgtcg attgctcaat acggacaaga ttcgtacccg tactagctgg aaacctatca
     8701 tcactctcga tgaaggcctc acgatgtgtg taaatagtat caagaaatga aatatttgat
     8761 tataactgtt gctggaacgg ctacgcgttt taatcgcgac actaaggaag aaaccctcaa
     8821 atgcttgtat tataccgatg aacctcaata cgctcttctt gctcaattgc tgaagaattg
     8881 tggtgagtac gataaatata tccttgtggg gggctacctt tatgagaagt tgggaagatt
     8941 tgtaaagaac gaactctctg gttatggcaa aaaaatagaa cttgtttaca acgagcattt
     9001 caaagactat ggctccggct acagtttata caaaggtata gaggcaataa aggaggcagg
     9061 tgatgtgact ttcgtagaag gcgacttgtt ctttatggct acagatttca ggcaagtgta
     9121 taattcgcca aagagtgtga ttaccattaa ccgagaacca atctactcga ataaggcagt
     9181 tgcgttatac attaacgttg atggcaaacc aaggtattta tatgatacga atcatcagac
     9241 attaactgta tcagagccat tcaaggcaat cttcaacagt ggtcagatgt ggaaattttc
     9301 ttcatctgag aggcttttga agactgttga ttcgcttaca aaagaacaac ttcaaggtac
     9361 taatcttgaa ataattcagg cttactttag tgatatgaat agtgaagagt atgatgtagt
     9421 gactttcact gactggttca actgcaatac tgttgcagat tatgatattg taagaaaatt
     9481 gatgtaaaaa tgaatatggc tgtattagaa agagattaca gaatagatgg aataaagtgg
     9541 ttgctcattg tattagttac attcggtcat gtaatagaac ctgctttaag caatcctatt
     9601 gccaataagc tctattctat aatctacatt tttcatatgc cattatttgt ctttatcagt
     9661 ggttattatg caaatgttaa ggataaagaa aaactgatta gtaaaggttt tatgcttttg
     9721 gaaacatttt tggttgtgat gattcctcaa tgtttttatt atggaagtat catcccttta
     9781 ctaaatccgg agaactcagg ctggtattta atcagcctaa taacttggta tattattttt
     9841 ctgttgatta tcaataagct agttggcaaa attgtcgtac aatataatgg gtgcgggggg
     9901 ggcagttatt gatattcagt tgcttgttgg ccgtatttgc atacatgctt ccgttgaaac
     9961 aatttggtaa cctgctatcg ttccaacggt cgtgtatgtt tctaccattc tttatgatgg
    10021 gtttcttgag aagagtaaaa ggcctgccta ttattcctga tgtttcaaaa tgcataaagc
    10081 ttgttttggc tatagcctct ttagtatgtt ttgctttttg tctcatctat agtggtcgta
    10141 tactacatgt attagagttt aataatgcca atgtgtggca catgtcaaat ttgtacaatc
    10201 aaaatatagg aatgcttctt gttttgaaag tattggttta tattggatca attattacta
    10261 cattcgctgt tttaatgttt gtgaacctcc ccaagtcgat atgtgcttat ggatcaaaga
    10321 ctttagcata ttatgtaata caaggcatgt ttgcacacat attatcaacc tatttgcaag
    10381 ttaattttta ccaggccttg tttctctgtg tttgcatatt aatccttaca acagttctat
    10441 tacgatttgt tgattctaaa tttattacaa acccgttttc tactttatta aaatggaaat
    10501 actgaacaga aaactttccc ttctcaaagg gaaggttgaa aatagtcagc caataactat
    10561 tatgattatt ggtttgggta gcgttggatg ctacttgttg gattatcttg tatcactagg
    10621 tgattcacaa cttcgtcttg ttgtggtagg acgtaatgcc gaaaagatgc agatggatat
    10681 aaatattatt cgtactgctt caaccattcg tcaccagtgc cgtagcgaga ttaaggtggt
    10741 tgataactgc gaccttaacg atgtgaacag cattgcagct gtacttgaag cagaaaagcc
    10801 tgacttcata gtaaatagta gtcgagttta ctctggtttg aagtatggta gcatctcatg
    10861 gagtaatctt cgtgcatacg gcatttggac tccgctttct attcgatatg caaagaatat
    10921 aatggaggca tacgataagg ccaactgtga ggcaatctca atcaatactt catattccga
    10981 tgctgttatt ccttggctaa agtctgcggg taaggcttat tttgactttg gtagtggtaa
    11041 tttgaatcat cttgtgcctc gtataaaatt ctatattgca gagaaatatg gtataaagaa
    11101 ttttaatgac attgatgtaa ctattgcggt atcacatttt catgatgttg tcatttctaa
    11161 ggaaggtcat gcagaaggtc aggacatctt gcttgatata aagtttcaag gcaaggatat
    11221 ggattttaat aaggaagaac ttcttaaatc ctgttctata gcaatgcctg tagatcagaa
    11281 gcgcaatatg atgaatgctt ccagtaattt tgatatcata ttctctgttc ttactgctct
    11341 tcgagaggaa aaacaagtca aaatacatac tcctggggta aatggtgaaa ttggtggtta
    11401 tcctataatt attgatggag taactgctac tgccaagttt gatgagtctg tatggactat
    11461 agaccagatg cgtaaagcta accgtgagtc aatttattgt gatggagtag agaatataac
    11521 tgacgctact ctcgtctata ctgatgaact tgtagctaag gtaaagaagt cgtttaatgt
    11581 tgatttgcct aagtcggtaa agtttgtgga tattgaaaat gtagcagatt taattatcaa
    11641 tcagataatt aaacctcaag tgcttatttt tgtgcaataa tttgtaaact aatggcagat
    11701 aatagattgt tgttaatttt ctgtataatc tttaacttat agttttatga tatacacagc
    11761 tatgtaagca ctttaaaaag ttcaaaatga aatgttagcc ttcgttgtaa attaaaatta
    11821 gcaagatatg tatagcagcg aagatttagc aagtttttat tttcagtacc agaccaaggc
    11881 tttacctcat gtcaagttcc tccagtcctt ttgtatgaag cataaagttc ctataatatt
    11941 tttcataagt ggtataagga tacgcgtaat aaaataatta cagttctata tctccgattg
    12001 tcaaatgaaa aatgtaataa atatggatat cacaacaaag ataaaaagaa gtaaattact
    12061 ttattacgtc tactattacg taatgtcagg tttggtaaat ttgtacaagt tgttcttgaa
    12121 gccagacggt aaactcatgc tttttgtatg ttatggtgga cgtcattatt ccgatagtac
    12181 gcgagtgatt tatgaggcca tgttgaagga tgaacgtttc aaggactata taggattacg
    12241 acaaactgat tgctgcattt attgatttaa gagaaaagcg atttatctaa ggt
//
