LOCUS       gnlProkkaLGALIMHA_250  22132 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LGALIMHA_250.
ACCESSION   gnlProkkaLGALIMHA_250
VERSION     gnlProkkaLGALIMHA_250
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-30 22:30:23
            Original ID  :: gnl|Prokka|LGALIMHA_250
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22132
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22132
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2097:17132]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2098..17132
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..22132
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22132
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(3..362)
                     /locus_tag="ctg250_1"
                     /transl_table=11
                     /translation="MNMAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSII
                     YIFHMPLFVFISGYYANVKDKEKLISKGFMLLETFLVVMIPQCFYYGSIIPLLNPENSG
                     WYLISLITWYIIFLLI"
     CDS             complement(365..1105)
                     /locus_tag="ctg250_2"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKKELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             complement(1102..2097)
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg250_3_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg250_3"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.8e-09,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.9e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        complement(1504..1848)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg250_3_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg250_3_NAD_binding_4.1"
                     /locus_tag="ctg250_3"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             complement(2098..2826)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg250_4"
                     /sec_met_domain="Metallophos_2 (E-value: 1.3e-27, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             complement(2830..3957)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg250_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.8e-20, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-23, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             complement(3992..5302)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg250_6"
                     /sec_met_domain="CTP_transf_like (E-value: 3.5e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4e-114, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.5e-61, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             complement(5327..5701)
                     /locus_tag="ctg250_7"
                     /transl_table=11
                     /translation="MTYRQVGTNSFTVKYYVEKFILDMNTMKIIRVDEYRDKKKINRPA
                     GSLFSVDGEIYRVAQKCSRAYGESIFVYKTSKNFDFIKDKKVAELTGQSIVLSDGRKPI
                     LLHTYSQAGGIEVIDYRCSL"
     CDS             complement(5698..6450)
                     /NRPS_PKS="Domain: Aminotran_5 (3-189). E-value: 1.1e-20.
                     Score: 65.7. Matches aSDomain:
                     nrpspksdomains_ctg250_8_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg250_8"
                     /sec_met_domain="Aminotran_5 (E-value: 3e-18, bitscore:
                     57.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDK
                     ALVINGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETF
                     TGVHYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIA
                     VMLLAPSAIKRIEKVQCCCQYLDLKLALKNMERGQTPCTPAVGILRQINVRLKEIESAG
                     GAEVEIARCAELAKYFRDKLVKNNLPLF"
     aSDomain        complement(5884..6441)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg250_8_Aminotran_5.1"
                     /evalue="1.10E-20"
                     /label="ctg250_8_Aminotran_5.1"
                     /locus_tag="ctg250_8"
                     /protein_end="189"
                     /protein_start="3"
                     /score="65.7"
                     /tool="antismash"
                     /translation="ENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDKALV
                     INGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETFTGV
                     HYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIAVML
                     LAPSAIKRIEKVQCCCQYLDLKL"
     CDS             complement(6447..6548)
                     /locus_tag="ctg250_9"
                     /transl_table=11
                     /translation="MINFTVGPVQSSDAVRVIGAEQVPYLEQQSFQK"
     CDS             complement(6732..6872)
                     /locus_tag="ctg250_10"
                     /transl_table=11
                     /translation="MGKNFIHPSLGFFIERTRKQSGVTIETLCKDLHISPSTYIDLKKR
                     V"
     CDS             7047..7649
                     /locus_tag="ctg250_11"
                     /transl_table=11
                     /translation="MPPISPMKDGATRKIVKSATLTPLRTLELNEVYQLITANKRLITL
                     TQAIREAALQGDDNNCRMLKQQTLPYVTPCGVFTRRRSDCLKLPSGLVVVDVDHLDSPD
                     EAGRLKQLLFKDPYLAPVLVFISPTGRGVKAFVPCPIGKDSTEAVRWAMNYVHCMYDAE
                     NTQPGKGVDTSGKDLVRACFLCHDPKALLRKVVNFEL"
     CDS             8151..9476
                     /locus_tag="ctg250_12"
                     /transl_table=11
                     /translation="MSCGTSLAQYDVLLLGAITVLGASMGKHVRCSYGGKMMSPCLQTF
                     VVALPASGKGVLSLVRLLAEPIHDEIRGQVDESMACYRREKAKYDTLGKERGKTETPVM
                     PLNKMFLISGNNTGTGILQNLMDSDGTGLICESEADTISTAIGSEYGHWSDTMRKAFDH
                     DRLSYNRRTDHEYREVKKTYLSVLLSGTPSQVKPLIPTAENGLFSRQVFYYMPAIHHWQ
                     NQFDRNDSDLEDTFKALGMEWKDKLKTIVMNGIFTLHLTDGQKDEFNRLFSRLFVRSGL
                     ANGNEMSSSVARLAINICRIMEVVAMLRAMEQGEITASPYVSPDPHTATDNLKDHIVSR
                     WNLLIASDDFHAVLSLAESLYRHTTHILSFLPNTEVTSRGNADRDALVDSMEEEFTRAS
                     FLQKAGEMGIKSETASTWLKRMQKHGLVENVDGKGNYRKPKV"
     CDS             10142..10513
                     /locus_tag="ctg250_13"
                     /transl_table=11
                     /translation="MSNHNTPYSSGVIKGVLADMVSCTKELILDGKNVKLDDLAIFSVG
                     IVSKKGAQSAADFSLANNVKGLKLRARATGELSNAQINLDGQLKESSLYTVGGKAPDGS
                     GSDGGSGGSDGNQGENPLG"
     CDS             10560..10667
                     /locus_tag="ctg250_14"
                     /transl_table=11
                     /translation="MSEDKKSKSVWGIVLKVIITVATAIAGALGLGACK"
     CDS             10670..11083
                     /locus_tag="ctg250_15"
                     /transl_table=11
                     /translation="MRTITLLIVHCSATPQGVALGFEDCRRDHIHHRGFRDIGYHFYLT
                     RNGEIHRGRPLEKIGAHCLNHNRHSIGICYEGGLDAASFPADTRTLEQKASLLALLREL
                     KRIFPRALIVGHHDLNPTKACPCFDAEKEYRGL"
     CDS             complement(11221..12237)
                     /locus_tag="ctg250_16"
                     /transl_table=11
                     /translation="MRDKCMIVAEMSANHNGKKETAIETVRAAKRAGADAVKLQTYRAD
                     TITLRCDKPDFIINEGSIWDGQYFYDLYEQAYTPWEWHEELFHVAKEEGLICFSSPFDK
                     TAVDMLEALDCPVYKIASFEITDIPLIEYAASKHKPMVLATGIATEEDIQLAVEACRRM
                     GNNDITVLKCTSSYPAPVEEANLCMIRDLAERFQVKSGLSDHTLGSVSPIVAVTQGASM
                     IEKHFILNRSIGGPDCSFSMEEKDFAQMVKDVRMAELSLGKTTYELTEKMRGSRSASRS
                     LYVAEDMKAGEVITERNVRSVRPGFGLHPKYLKDILGKNVNRDLEKGTRFALEYVNG"
     CDS             complement(12245..13384)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 60.5; E-value: 2.7e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg250_17"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.1e-15, bitscore:
                     47.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.3e-12,
                     bitscore: 37.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLLILGAGEMQVPVIRKANDMGLHTIVADMDANAPGMGYASE
                     PVLVSTMDKEGVLECAKRHSVDGILTTSDAPVNVVSYVGEQLGLPSMSTEVAKICTNKY
                     LQREMFAANGIDVPFFMLCDKDTDLGTLQDYPYIVKPVDSSASRGVKKVTNHKELVLAF
                     SEALGYSRTGKAIVEGFITGREFSVETYTQNNKTTVVTITEKLCIGEAEGFFVEDTHIE
                     PARITKQEWELVSETVSKALCLIGLNNCPSHTEIKLNESGAYIIEIACRLGGDYITSDL
                     VPLSTGIDMLRNLVNCSLGLPVDVLRKHEKCSAVQFLNPLNYQRCVDFLSSSRSSAVFR
                     SEIRPYSEKKIKNSLDRLGYIILQTDSMEELESILRTIK"
     CDS             complement(13381..14316)
                     /locus_tag="ctg250_18"
                     /transl_table=11
                     /translation="MQVTSQRASAILYNYLSGNHFDKPFLLPANVCPVVPLSFMKAGVG
                     FEFIDIDESHAMSTEKCLTAIEAGKYSGLVFVHAYGKKYDNKEFYRAVKSLDPNLCIID
                     DCCLCIPELADSLPENVDLCLYSTGYAKFIELSYGGYASFRGGYEVVDYQYDSISEQKH
                     SVYIRKCLLENVRYMLPADYPWLDASNLQMTDEEYFDIIERKLPKVIAEKEKINKIYRN
                     LLPESIQMGDDFQNWRFMIVIENRQKVLDAIFKAGLFAGTNFPSVSYMFKGVSSPVAEV
                     EAKHIVNLFNDFRFSEAQARKICDVINSVI"
     CDS             complement(14307..15284)
                     /locus_tag="ctg250_19"
                     /transl_table=11
                     /translation="MQKIYLRADASAAIGYGHFIRTLALADMLKDDFDCTFFTCHPTPY
                     QVSEMEKVCPFIPLQEESHYDEFLSLLQGDEIVVLDNYFFTTDYQRAIKQKGCCLVCVD
                     DMHDKHYVADLIVNQGLGYTRDDYSCEPYTQFAFGLQFSLLRRPFFNVALQNQRNNYSG
                     GLYVLVAFGGSDFLNLTYQTIHAIKAKDNVKKITAIVGDSYAAENMVDDPKVTYQKNLS
                     AGSIADLFSTVDVAILPASTMMNEALACGTPVIGGYYVDNQEHDYYMFLREGLIQGAGD
                     YTDAAAFTLVAENLDKMAIRKRHAITPDIPKRFVNLFKSLLICK"
     CDS             complement(15289..15972)
                     /locus_tag="ctg250_20"
                     /transl_table=11
                     /translation="MKNIAIIPARGGSKRIPRKNIKPFMGKPIIAYSIEAALQSGLFEE
                     VMVSTDDEEIAGIACKYGAKVPFMRSAEMSNDYAGTDDVILEVLRKYKEQGREFETVCC
                     IYSTAPFVTPERLREAYGKMNSEIDSVFTCVAYSYPIQRSLHIVDGKISMVYPEYKNAR
                     SQDLEPIYHDAGQFYFSRTAPFVESRTFWGENTAGLVLSELEVQDLDTQTDWALAEMKY
                     ELLHK"
     CDS             complement(15969..17132)
                     /NRPS_PKS="Domain: Aminotran_1_2 (35-167). E-value:
                     1.3e-13. Score: 42.6. Matches aSDomain:
                     nrpspksdomains_ctg250_21_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     330.2; E-value: 2.8e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg250_21"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1e-112,
                     bitscore: 368.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 8e-14, bitscore:
                     42.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISKPIPYGRQHITDEDIRAVIDTLKSDYLTQGPKIREFETKFAE
                     YVGAQYAVAVNNATSGLHLAATALNVKPGDKVIVTPMTFAASANCIRYCGGEVVFCDID
                     KDTYLMDIRKLEAMLKASPRGTYKGIVPVDFAGYPLDLEEFRKLADEYGLWIIEDACHA
                     PGGYFMDSKGKKQHCGNGCFADCAVFSFHPVKHIATGEGGMVTTNSKELYDKLCLYRTH
                     GITKDPALLHEHHGGWYYEMQELGYNYRLTDFQAALGISQLERAKAGLERRHEIVRRYN
                     EAFSGIDGIKTPFNTADVYHAYHLYIIQVADRLGLYNYLHENNVYAQVHYAPLHLMPYY
                     QQWGNRKGDLPIVEEYYEHCLSLPMYPTLTDEEQEYVIEKVIEFVAK"
     aSDomain        complement(16632..17027)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg250_21_Aminotran_1_2.1"
                     /evalue="1.30E-13"
                     /label="ctg250_21_Aminotran_1_2.1"
                     /locus_tag="ctg250_21"
                     /protein_end="167"
                     /protein_start="35"
                     /score="42.6"
                     /tool="antismash"
                     /translation="IREFETKFAEYVGAQYAVAVNNATSGLHLAATALNVKPGDKVIVT
                     PMTFAASANCIRYCGGEVVFCDIDKDTYLMDIRKLEAMLKASPRGTYKGIVPVDFAGYP
                     LDLEEFRKLADEYGLWIIEDACHAPGGY"
     CDS             complement(17129..18151)
                     /NRPS_PKS="Domain: NAD_binding_4 (8-133). E-value: 6.5e-14.
                     Score: 43.5. Matches aSDomain:
                     nrpspksdomains_ctg250_22_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg250_22"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.4e-97,
                     bitscore: 316.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.7e-15, bitscore:
                     47.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.9e-14, bitscore:
                     43.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNNKSVLITGGTGSFGKKFVETILRDYPQVKKIIIYSRDELKQF
                     ELKQKYPGHKYPQLRFFIGDVRDLERLTRACEGVDVIIHAAAIKQVDTAEYNPEECIKT
                     NVHGAQNVIKAALATGVQHVVALSTDKACAPINLYGATKLTSDKLFTAANNISGSKDIR
                     FSVVRYGNVMGSRGSVIPFFINKRDNGAKELPITDMRMTRFNISLEAGVALVMYAIGHH
                     LGGEIFIPKIPSYHIQDVATAIAPNLPQVEVGIRPGEKLHEEMITVTDALDTIDLGRYY
                     VILPSVSFKHSREEFIRHHNAVPVPDGFHYSSDNNTEWETVETMRENIKKYVDPNFEVK
                     "
     aSDomain        complement(17753..18127)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg250_22_NAD_binding_4.1"
                     /evalue="6.50E-14"
                     /label="ctg250_22_NAD_binding_4.1"
                     /locus_tag="ctg250_22"
                     /protein_end="133"
                     /protein_start="8"
                     /score="43.5"
                     /tool="antismash"
                     /translation="ITGGTGSFGKKFVETILRDYPQVKKIIIYSRDELKQFELKQKYPG
                     HKYPQLRFFIGDVRDLERLTRACEGVDVIIHAAAIKQVDTAEYNPEECIKTNVHGAQNV
                     IKAALATGVQHVVALSTDKAC"
     CDS_motif       complement(18089..18136)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg250_22_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg250_22"
                     /protein_end="21"
                     /protein_start="5"
                     /score="11.0"
                     /tool="antismash"
                     /translation="SVLITGGTGSFGKKFV"
     CDS             complement(18165..18653)
                     /locus_tag="ctg250_23"
                     /transl_table=11
                     /translation="MSLSEEAITLQRAAHELMYLGMDGSPVYSDDLSRRNGEVYRLTMA
                     LYRSGVKGTTIEEQANVCLALLMGYSASFVDHGEKQQHVQEVLDCCWDVLDALPASLLK
                     LRLLTACYGEVFDESLADEGRSIIASWDSLSLTPEQQEAVDEFQNVTDNPYPWEYIDE"
     CDS             18809..19288
                     /locus_tag="ctg250_24"
                     /transl_table=11
                     /translation="MPLKFTAGNPDFGAFGQVQFIRLKIKKMIIVSAGYGNETLHLTVW
                     DNNLLPTAGIGDILQISDLRFYTLHIGRTGMDKKQIMNDRNQSTDFFPFFYTYLVLHRN
                     ETAQIFFLEQMHGIRFSAVGGTHSIPDFDLFLYSHFYAFVQTRVFSWGFEPLAYT"
     CDS             19334..19555
                     /locus_tag="ctg250_25"
                     /transl_table=11
                     /translation="MPFLSTDFLQSFITCQVKCCKRIYCKQKAFNRRSFFERQYLRKLK
                     REDYLKISKRKKLEKYNAIGLLTKYYTH"
     CDS             19708..20421
                     /locus_tag="ctg250_26"
                     /transl_table=11
                     /translation="MFIEIRFLQTRYQLKKKLLFSEVKDTQFRESSPLHCKTDSEASRT
                     YNPKNNQRPLQTGIHRLPFEYLTEDGPYKTDQRNSYQQDSCNVHHNGRQRRSRQYHISH
                     REKGNESRTATNSHRYRSKQQRHKYHSKYKQYRTADNGKYHQTDFQEPADNHHQCISQL
                     LQESTGFVRPHIIIHPIGNLLKTVRHRLSDILYRNGLATHTQLLGCCAGFRYNQPTHDI
                     DRYQCPYPTNQDDKQ"
     CDS             20834..21325
                     /locus_tag="ctg250_27"
                     /transl_table=11
                     /translation="MKTVPPKFTVNVFFITHYLFTILLFTIYHPANYGIFSSAISRIAD
                     VIHRLVQLFPGCFQFTEKDFSFFRQPVIFTGRPLCRLNPFIPQKVVVLQTGEQRIKCTF
                     HHNQSGFFQLLNDIRSISRLFVKQQHDAIFKHALAHLRLYIVYIHNGIYYLTIYYLAAQ
                     "
ORIGIN
        1 ataatcaaca gaaaaataat ataccaagtt attaggctga ttaaatacca gcctgagttc
       61 tccggattta gtaaagggat gatacttcca taataaaaac attgaggaat catcacaacc
      121 aaaaatgttt ccaaaagcat aaaaccttta ctaatcagtt tttctttatc cttaacattt
      181 gcataataac cactgataaa gacaaataat ggcatatgaa aaatgtagat tatagaatag
      241 agcttattgg caataggatt gcttaaagca ggttctatta catgaccgaa tgtaactaat
      301 acaatgagca accactttat tccatctatt ctgtaatctc tttctaatac agccatattc
      361 atttttacat caattttctt acaatatcat aatctgcaac agtattgcag ttgaaccagt
      421 cagtgaaagt cactacatca tactcttcac tattcatatc actaaagtaa gcctgaatta
      481 tttcaagatt agtaccttga agttgttctt ttgtaagcga atcaacagtc ttcaaaagcc
      541 tctcagatga agaaaatttc cacatctgac cactgttgaa gattgccttg aatggctctg
      601 atacagttaa tgtctgatga ttcgtatcat ataaatacct tggtttgcca tcaacgttaa
      661 tgtataacgc aactgcctta ttcgagtaga ttggttctcg gttaatggta atcacactct
      721 ttggcgaatt atacacttgc ctgaaatctg tagccataaa gaacaagtcg ccttctacga
      781 aagtcacatc acctgcctcc tttattgcct ctataccttt gtataaactg tagccggagc
      841 catagtcttt gaaatgctcg ttgtaaacaa gttctttttt tttgccataa ccagagagtt
      901 cgttctttac aaatcttccc aacttctcat aaaggtagcc ccccacaagg atatatttat
      961 cgtactcacc acaattcttc agcaattgag caagaagagc gtattgaggt tcatcggtat
     1021 aatacaagca tttgagggtt tcttccttag tgtcgcgatt aaaacgcgta gccgttccag
     1081 caacagttat aatcaaatat ttcatttctt gatactattt acacacatcg tgaggccttc
     1141 atcgagagtg atgataggtt tccagctagt acgggtacga atcttgtccg tattgagcaa
     1201 tcgacgctca ggatcagact ttcggtaacc ttcgaaacgg atatccacat cgttgatgcc
     1261 catttttatt gcaatcgtct tgactagatc aataatggca atttcctctt cagtagccac
     1321 attataaaca gtaccatcaa gagcatcctc agaagcgatg agctccataa cggcacgaca
     1381 gctatcaata ttatgaagga aggtacgttt gttcaccttc gagttttcaa gaagggttac
     1441 ggtatggctt tcaagcagat tatcaatgat atgagggata atgtgctctg caaaacgctc
     1501 gtgcctgcta tatacattag caaagcgaat agaacaacct ttaattcgtc ccttgccaac
     1561 agcatctttc ataaagaatt cagtcatcaa cttgccgcaa gcataacttg tacgttggct
     1621 atgttccgct gttgacattg ccaaataatc agattctttc acaccgccat tctcattcca
     1681 agactgcatt gagtaaacct ccgaagttga acaattaatg taagtatcag ccctcataga
     1741 aatggcacgc tccaagaaat ccttcatagc aaggacgtta gtctgaaaag tactctctac
     1801 ctcatagaaa tgctttgtat ggacaacagc agcacaattg ataaacacca gacggccatc
     1861 gcactcaatt ttgagttctt tcgccttatc gcatacttca tccatctgag cgactttgtt
     1921 aatgtcgtaa ttatagaaga tgaacgaggg attgtcaata atgtctttaa cggtatcaat
     1981 agaacttgca aagaagttgt cgaaaccgat taccgtatga ccctgagaaa caaactgacg
     2041 agacagttca ctacccgtca tgccagtaac accacttatt acatataagt tcttcattta
     2101 tattccaaat tttaatcgtt cgctgtaaaa agtatctatc tctttgggga aaagagattg
     2161 ttcagcttca atatcgtaag gaactgcatt gaaatgggtt tcccccgttt taaaattgat
     2221 atacacatat tgtgcatatg gattctgatt gcgaggttgt ccaactgaac ctgggttgat
     2281 aaaagtcgta cgtttctgat tgcgcatgat tggattgtca actttgaaga atacatctat
     2341 cttaaaaggt tgatgaatgt gaccgctcaa tacgtagtca aaatcctgat acttttcatc
     2401 ttccactttt gctggagtca gttttcccca atagggatca tcaatagttc catgtaaaag
     2461 aagtactttc ttaccaccaa tttccaactc ttgcattggc tcttgcatca cattgcttat
     2521 ataatcaata gatgtctgag tgagatggtt tcttgtgtat ttggacatca cacgagctct
     2581 ttctgaagag aaacatgaga gttccccatc aatcaaagcc ttctcgtgat tgcccttcaa
     2641 attggcaagt aatggaatat taacagtttg tatacgttca ataatttcat ttgaacgcat
     2701 accatagtcg ataaagtcac ctagactaat catggcatct ggctgatagt gtttctcaat
     2761 atcagctaga accgcctcaa aagcagaaag attggcgtgt atatcagcaa acagaattac
     2821 tttcatactt tacttgttaa gaaattccat aaaagcctct ttgttctgaa taggagttgt
     2881 agttggacgg ccaaggtcct tgcggtttcc cttttttacg caaatctgaa ggaaaacagg
     2941 accttctgcg ttcttgaatt ctgcaagttt tgcttcaagt gcctccatag tttctacact
     3001 ataagcagcc ttgtagccta cagcttgagc aattgcacaa aaatcaatct tgagaccaac
     3061 agtaggctga ccaccaacag aatcgtgtgc gccattgttg aacacaatgt gcacataatt
     3121 cttgcatttc atgctggctg taatagccat attacccatg tgcatgatgc tggctccatc
     3181 accatcaaaa caatatactc gacgctcagg cttttggaga gctatgccga gagctatctg
     3241 ggaagcatgg cccatcgccc ctacagtaag gaaatcacgt tcatgacctt ggctccaagc
     3301 agtacgtgcc tcaaagagct cgcgagaaat cataccagta gttgatacga tacaagcatt
     3361 atcttcaatg tttgaagcca ccttctgaat cgtctcttcg cgagacattg ccagttcgtt
     3421 tacctcaacg ctctgaagct tataggtatc gaaagtatcc ttctctatca caagggcata
     3481 gcactcgttg gttgccttca tgaagtcgac agctattttt atctgctttg cagctccctc
     3541 ttcatccttt ggcagaatag catagttgat acccatggta ttaagcaaac cgattgtcac
     3601 cttaccttgc ttcacatgct gaggttcatc gtgaactcca gggcgccctc tccaaccgat
     3661 aacgaggagc acaggaatgt tataaacgtc cttgtcggta agagaggcaa acggattaat
     3721 gatattgcct tcaccagagt tctgcatata aactacaggc accttacctg ttgccaaatg
     3781 ataacctaca gcaataccca tggcccctcc ttcgttagca gcaataatat tctgctcagc
     3841 aggaaggtgg tcggtaatat atgcacaaat gttcttgagc aacgaatcag gaacaccagc
     3901 ataaaagtct ataccttgtt ccttgagtat atttacaaaa aattcgggtc ttaccatttg
     3961 taaaatagtt taaggggtaa gaaattaatg tttacttctt ctttgtgcct ggaataagat
     4021 taagaatctg tttgataggc atacagtact gctcagatgc ttcaagcgaa cggctagtat
     4081 agaggatggt ttctgcacat ttaaccattg caggataagc agaacgaagc atgtgattag
     4141 cataaatcac tacattaata ccccattcag caagttcctc ttctgtgaac tggttataag
     4201 tagtaggcac aacgatgata ggagtatgag cattcttctc gcgaaagcgc aagcaaaact
     4261 ccttgatgtc ctctccagac ttctctttgg agtggatcat tataccgtca gtacctgcct
     4321 ctacgtaagc atgacaacgc tccaaagcat catctacagt cttaccagca atgagagact
     4381 cacaacggct gacaatcatg aagtcacgag taatttgcgc ttccttacct gcacgaattt
     4441 tagcctgaaa accttcgatt gtatcctgag tctgtacagc atcagtacca aaaagtgaat
     4501 tctgttttaa acctacctta tcttcaatta taacgcaaga gattcccaag cgctcaaggg
     4561 tgcgaacggt aaaaccgaag tgttcaatct tgccaccagt atcgccatcg aagataacag
     4621 gttttgtggt tacttcaagg gtatcattga ggtcatggag acgggtagtc aaatcgacag
     4681 cctcaatatc aggcttaccc ttagaggtag agtcggtaag ggaggaagcc cacatgccat
     4741 cgaattcacg ctcctgacca ttcacctcta ccttagtatg ttctgctatg aggccagtaa
     4801 gaccattgtg actttcaaga atacgtacaa tcggtttagc tgcaataagg cgacggagag
     4861 aagaaagacg catctgagga gttacaccaa gagcatcaat ctcttgtttg ataccagaag
     4921 cagagatgtt ttgggtgtaa ggaatctcga taacctcacc acccaacttt tccattactt
     4981 tgaatacctc atcacggata tacttgtcag gacccacctg ccaatcatca ccatgaatga
     5041 tgtaatcagg cttgtactta aggagattag agacatagct ccaatcatcc tgagggacca
     5101 cccttgatac gttcctgatg ctctcaacaa cgttctttct ttgctcccaa gtgagataag
     5161 gaagtctacg gtggttagca atcgccttat cagtgaacaa accgattatc acatcgccat
     5221 actcagtagc tttgttaatg atgttaatgt aacccggatg catgatatca cctatcatac
     5281 caagataaac tgtctttgcc attattattt aacatttttc aaattattat aaagagcatc
     5341 tatagtcaat cacctcaatc cctcctgctt gagaataagt gtgcaacaaa atcggctttc
     5401 taccatcact caggactata ctctgaccag tgagttctgc taccttttta tctttaataa
     5461 aatcaaaatt cttacttgtc ttatacacaa agatcgactc tccatatgca cgactgcatt
     5521 tttgtgccac tcgataaatt tctccatcta cagagaataa cgaacctgcg ggacgattaa
     5581 tcttcttttt gtcgcgatac tcgtcaaccc taattatctt catcgtattc atgtcaagaa
     5641 taaacttctc aacataatac ttaactgtaa agctatttgt tccaacctga cgataagtca
     5701 aaagagtgga agattattct taacaagctt atcacgaaaa tacttagcca attctgcaca
     5761 acgcgcaatc tccacctccg caccacctgc agactcaatt tcttttaaac ggacattaat
     5821 ttgacgaagg ataccaacag caggagtaca aggagtctgc cctctctcca tatttttaag
     5881 agcaagcttc aaatcaagat actgacagca acattggacc ttttctatac gtttaatagc
     5941 cgaaggagca agaagcataa ctgcaatacc cggagcgcaa gcaagagcct tctgacttcc
     6001 agtaatcatc acccctacat ccattgccac catatcaaat gaatcgcaaa ggaaggtaga
     6061 gattatatca acaatcaaga aacaattatt acgtttgcaa aaatcagaaa caagattgat
     6121 atcgtaatgt acccccgtaa aagtttcgtg cttctgcata aggaaagtag tgtaaccctt
     6181 gctctcatat tcagcaagat gttcaggctt caaagctcta ccatacttaa gcttaatttc
     6241 cgtaaaagga attttatgaa gggtaagcaa ttccacaaaa cgctcaccaa agctaccacc
     6301 attgattaca agagccttat cctgtggcgt aaggcaattt atgatggcag cctccatacc
     6361 accagagcca gaacatgtca tgaaaacaac cttactatct ttagtcgcat tagcaaattt
     6421 cttaacaagg cgctcattct caagcatcat ttctgaaaac tctgctgttc taaatatggt
     6481 acctgttcgg cacctatgac ccgtacagca tcagaagatt gcaccggacc tactgtaaaa
     6541 ttaatcattt atatagattc ctttaattat cagtaataat caaccaatcc aatcaccact
     6601 cccccttctt cctaacctcc agccattttt ccacccattc cccagccaat ttcctgattt
     6661 cgtcatcatc cagttcctcc agttcatcga tatagtatcg cagaagagtt tcgtatgtac
     6721 taagtgaggc gttacaccct tttttttaag tctatgtacg tggatggaga aatatgcaaa
     6781 tccttgcaaa gagtttcaat agtgactcca ctctgttttc tcgttcgctc gataaaaaag
     6841 cccaatgaag ggtgaataaa atttttgccc atttagataa attttaagta attagataga
     6901 atattatgtt atatattgtt attatttact ttgttccttt aaaatctttc ttacatgtgg
     6961 gaaagattca acgaaagaga atgaatacct ttgagccaac tatttaaacg tataatatgc
     7021 caaaatcttt taaaatgtcg cttttcatgc cacccatctc accgatgaag gacggagcga
     7081 ccaggaaaat cgtgaaaagc gccacgctta cccccctgcg tactttagaa ctgaacgaag
     7141 tttaccaact catcacagcc aacaaacggc tgatcaccct aacacaagcc atccgcgaag
     7201 ctgccctaca aggcgatgat aacaactgcc ggatgctgaa acagcaaacc ttaccctacg
     7261 tcaccccctg cggcgtattc acccgacgac ggagcgactg cctaaagcta ccctccggac
     7321 tggtggtggt ggacgtagac catctcgact cacctgacga agccggacgc ctgaagcaac
     7381 tactgttcaa agacccttac ctcgcaccgg tactggtgtt catcagccct accggacgag
     7441 gtgtaaaggc ttttgtaccc tgccctatcg gaaaagacag cacggaggcg gtgcgctggg
     7501 ccatgaacta cgtccactgc atgtatgacg cagaaaacac acaacccgga aaaggagtgg
     7561 acacttcggg gaaagacctc gtacgcgcct gtttcctctg ccatgacccg aaagcactgc
     7621 tcagaaaagt tgtgaacttc gaattatgag tcattgcaaa tcaccgacta caaattacta
     7681 attataaatt accaaatccg atggaaccac tatcttcatt gcaccttctg gccgaagcag
     7741 tcagaaatgc aggagcagac attgctccaa cctatcaaga atatatacaa ctggcatttg
     7801 ccattgccac cgactgcgga gaagcaggac ggcatgattt tttaagtctg tgcagcctgt
     7861 cgtccaagta cgaccgacgg gcagccgaca agctcttcag caatgccttg aagaccggcc
     7921 gtaacgacgt gcatctagga accgcctttc atctggccga gctttgcggc gtgaagattc
     7981 agcatgaagc cgcacccgcc attggtacac ttggtacaca aagttcaccc ctctcttcta
     8041 cctcacacac acgcgcacgc gaggaagagt ccgcatcggg cattgaacca ctgtctccat
     8101 tacccacttt cgacgaacac ctccactggc cttatcccct gaatcgcatc atgagctgcg
     8161 gaacctccct cgcccaatac gatgtactgc tactgggtgc catcaccgta ttgggtgcca
     8221 gtatgggaaa acacgtccga tgttcctacg gaggaaaaat gatgtccccc tgcctgcaaa
     8281 cctttgtagt agccctacct gcatccggca aaggagtgct ctccttggta cgcctgcttg
     8341 ccgagcccat tcacgatgaa atacgtgggc aggtagacga aagcatggca tgttaccgcc
     8401 gcgaaaaagc aaaatacgac acactgggca aggaacgtgg aaaaacggag actcccgtaa
     8461 tgcctctcaa caagatgttc ctcatctcgg gcaacaacac cggaaccggc atcctgcaaa
     8521 acctgatgga ctccgacggt accggactga tatgcgaaag cgaagccgac accatctcca
     8581 ccgccatcgg ttcggaatac ggacactgga gcgacaccat gcgcaaagcc ttcgaccacg
     8641 accgactgtc ctacaaccgg cgcaccgacc acgaataccg agaggtaaag aaaacttatc
     8701 tttccgtact tctgtcaggc accccctcac aagtgaaacc actgattccc actgctgaga
     8761 acgggctctt ttctcgccag gtattctact acatgcctgc catacatcat tggcaaaacc
     8821 agttcgaccg caatgacagc gatcttgaag ataccttcaa ggctctgggc atggaatgga
     8881 aggacaaact gaaaaccatt gtcatgaacg gaatattcac ccttcacctt acggacggac
     8941 agaaagatga attcaaccgg ctcttctccc ggcttttcgt acgctccgga ctagccaacg
     9001 gaaacgagat gtcaagcagc gtggcacgtc tggccatcaa catctgccgc atcatggaag
     9061 tggtggccat gctccgcgca atggaacaag gggaaatcac cgcctcgcct tacgtgtcgc
     9121 ccgaccctca cacagccaca gacaatctga aagaccacat tgtcagccga tggaatctcc
     9181 ttattgcttc cgatgacttt catgccgtac tctcactggc cgaaagcctt tatcggcata
     9241 ccacccatat cctctccttc ctgcccaaca ccgaagtgac aagccgcggc aatgccgacc
     9301 gggatgcact ggtagacagc atggaagaag aattcacacg ggcctctttc ctgcagaaag
     9361 ccggagagat gggcatcaaa tcggaaaccg cctccacctg gctcaaacgt atgcagaaac
     9421 acgggctggt ggaaaatgta gatggcaagg gaaactaccg gaaaccaaaa gtctgacatt
     9481 cacttcgctt cacgcacgcg tatgtgtgtg aggcgaaagg atggatgaac ctctgtacca
     9541 agtgtaccaa cctcaccttt acgattcccg gcctgacctt tacgccatcc aacctcaggt
     9601 ttaaggctct ccaagtgcag ccactatcag ccgcacttgg gcaggcgtat aagagcggga
     9661 acgggaagaa ccgcccaaag cggaaagtcc gtcacgcaaa tcgggacaaa ggtctatcca
     9721 gtgtttcagt ttgcggaagg cagcctccgg acaaagattg ggacaataga tttgggccaa
     9781 ttcggtacgc ccgtatgtac gtatgacaaa agaatccata gttgacagtt acgatttata
     9841 tttcatcaaa agtaactata aatcatgata ttatcaaact tacaagcgta aataaccgac
     9901 taaaacagac ccaaacagac gagaacctgc aaaaaccgac aaacgcccgt atccacagcc
     9961 ttatctttgc atcgttgagt tcaacacagc aaatgttttt atcctttaac ttctaaattt
    10021 taattgtatg attcgttaca aaaagtatca agtgacgggc gaagacagcc cactgaaagg
    10081 cctctggtat gcacgccccg taatcgaaga aaccttcgac atcgaaaaat tggccaagca
    10141 catgtccaat cacaacaccc cctattcgag tggtgtcatc aagggggtac tggcagacat
    10201 ggtttcctgc accaaagaat tgattctgga cggcaagaac gtgaaactgg atgaccttgc
    10261 catcttctcc gtaggaatcg tcagcaagaa aggggcgcaa tccgctgccg acttctcgct
    10321 ggccaacaac gtgaaggggc tgaagctccg cgcccgtgcc accggcgaac tgagtaatgc
    10381 ccaaatcaac ctggatggac agctgaagga atcttccctg tacaccgtag gcggaaaagc
    10441 tcccgatggc agtggttccg acggcggttc cggaggaagt gacggcaatc agggcgagaa
    10501 tccgttagga tgagaataat tacaaattac taattactaa ttatcaatta ccaatcatca
    10561 tgagtgaaga caaaaagtca aaatccgtgt ggggcattgt cctcaaagta atcatcaccg
    10621 tagctaccgc catagcggga gctttaggtc tgggcgcttg caaatagcca tgcgtacgat
    10681 taccctgctc attgttcatt gctcagccac gcctcaaggc gtggccctgg gctttgagga
    10741 ttgccgccgc gaccacatcc accaccgcgg cttccgtgac atcggctatc atttctatct
    10801 gacccgcaac ggcgaaatac accgcggccg cccgttggaa aaaataggtg cgcattgcct
    10861 caatcacaac cgccattcta tcggcatctg ttatgaagga ggactggatg ctgcaagttt
    10921 tcctgccgat acccgtacat tggaacagaa ggcttcgtta ctggcactgc tacgtgagtt
    10981 gaagcgtatc tttccacggg cgctgattgt ggggcaccat gacttgaatc cgacgaaagc
    11041 gtgtccgtgc ttcgatgcgg aaaaggagta tagggggctg taaaaggatc cctataatcc
    11101 tttatttgag tctttatatt tcagaaccta aagtaatcaa cttttccata tccattacct
    11161 acgaacaaag atagaaaaat aaattccaga cctctatttt atcttcttat ttttatcagg
    11221 ctaaccattc acgtactcca atgcaaacct cgtccctttc tccaaatccc ggttcacgtt
    11281 ctttcccaat atatctttca gatatttggg gtgcaggccg aagcccggac ggacggagcg
    11341 aacgttccgc tccgtaatca cttctccggc cttcatatcc tcggccacat agagagaacg
    11401 tgatgcggaa cggctacctc tcattttctc cgtcaattcg taagtcgttt tccccaaaga
    11461 taactcagcc atgcgcacat cttttaccat ttgggcaaaa tctttctctt ccatagaaaa
    11521 agaacaatcc ggaccaccga tggaacgatt caaaataaag tgcttttcta tcatactcgc
    11581 accttgagta accgccacaa tgggagagac actccccagg gtatggtcgg aaagtccact
    11641 ttttacctgg aaacgttctg ccaaatcacg aatcatacaa agattggctt cctcaactgg
    11701 agccggataa gaagaggtac acttaagaac cgtaatatca ttatttccca ttctgcggca
    11761 agcttcaaca gccaattgaa tatcttcttc ggtggctatg cctgtagcaa gtaccatcgg
    11821 cttatgcttc gaagccgcgt attctatcaa tggaatatcc gtaatttcga aagaagctat
    11881 cttataaacg ggacagtcca aagcctcaag catatcgacg gctgtcttat caaaaggaga
    11941 agaaaaacag atcagtcctt cttccttggc cacatggaac aactcttcat gccactccca
    12001 aggagtataa gcctgttcat acaaatcata aaaatattgc ccgtcccata tagagccttc
    12061 attaattata aaatcaggct tgtcacagcg aagcgtaatg gtatcagccc gataggtctg
    12121 caacttgacg gcatcggctc cggcacgttt tgcagccctg acggtttcaa tggctgtttc
    12181 tttcttaccg ttatggttgg cagacatctc agccacaatc atacacttat ctctcatgtc
    12241 tttactattt aatcgtcctt agaatacttt caagctcttc catactatca gtctgaagta
    12301 tgatataccc taaacggtct aaagagtttt ttattttttt ttcagaataa ggtcttattt
    12361 cagaccgaaa aacagccgat gaccgggaag agcttagaaa atccacacaa cgctgatagt
    12421 tgagcggatt aaggaactgt accgctgagc atttttcatg tttgcgaagg acatcaacgg
    12481 gcaaaccaag agaacagttc accagatttc tcagcatatc tatcccggtt gacaatggaa
    12541 ccaaatcaga ggttatataa tctcctccaa gccggcaagc aatttctatg atataagcgc
    12601 ccgattcatt cagctttatt tctgtatgcg aggggcaatt attaagtcca atcaggcaaa
    12661 gtgcttttga tacggtctcc gaaaccagct cccactcctg tttcgttatc cgcgccggtt
    12721 caatgtgcgt atcttcaaca aagaagcctt ctgcctcacc gatacaaagt ttctccgtaa
    12781 tagtgacaac ggtagtttta ttgttttgcg tatatgtttc aacactgaat tcacggcctg
    12841 ttataaagcc ctcgacaatg gcctttccgg tacgggaata accgagagct tcggaaaaag
    12901 caagtacaag ttctttatga tttgtaacct tttttactcc gcggcttgca gaggaatcta
    12961 ccggtttgac aatatatgga taatcttgca atgtgcccaa gtccgtatct ttatcacaaa
    13021 gcatgaaaaa tggtacatca atcccgttgg ccgcaaacat ttccctctgc aagtatttgt
    13081 ttgtacagat ttttgcgacc tcagtggaca tggacggaag ccccagctgt tccccgacat
    13141 aggaaaccac atttacaggc gcgtcacttg tagtaagtat gccgtcaaca gagtgacgtt
    13201 tggcacattc caaaacacct tccttatcca tcgtgctgac aagaaccggt tccgaggcgt
    13261 accccattcc cggagcattc gcatccatat ctgcgactat ggtatgcaat cccatatcgt
    13321 tcgcctttcg gatgacagga acctgcattt cacctgcgcc cagtatcaat aatcttttat
    13381 tcatataacc gaatttatca catcacagat ctttcttgcc tgtgcttcac tgaaccggaa
    13441 atcattaaac aaattgacga tatgcttcgc ctccacttcc gcaacaggag aagaaacacc
    13501 tttgaacatg tatgaaaccg aagggaaatt agtcccggca aacagaccgg ccttgaatat
    13561 tgcgtcaaga accttctgcc ggttctcgat gacaatcatg aacctccagt tctggaaatc
    13621 atctcccatc tgaatcgatt caggaagcag attcctgtat atcttgttta ttttctcttt
    13681 ttccgcaatc acttttggga gctttctttc aatgatgtca aaatattcct catcggtcat
    13741 ttgcaaattt gaggcgtcca gccaaggata gtcagccgga agcatatatc tgacattctc
    13801 caggagacat ttccttatat ataccgaatg cttttgttca ctaatgctat catactgata
    13861 atcaacaact tcgtaccccc ccctaaaact tgcatagcca ccataggaaa gttctatgaa
    13921 tttggcatat ccggtactgt aaaggcagag atccacattt tcaggcaagg aatctgccaa
    13981 ttcgggaatg cacaagcaac aatcatcaat gatacaaaga tttggatcga gacttttcac
    14041 tgcccggtaa aattctttgt tgtcatactt tttcccgtag gcatgcacaa atacaagacc
    14101 ggaatatttt cccgcctcta tagctgtcaa acatttctcg gttgacatgg catggctttc
    14161 atctatgtct ataaactcaa aaccgacacc tgctttcata aacgacaggg gcactacagg
    14221 acacacattt gccggcaata agaacggttt atcaaaatgg ttgccagaca gataattata
    14281 caatatggcc gaagctcttt gtgaagttac ttgcatatca acagactttt aaacaaattg
    14341 acaaaccgtt tgggaatatc cggagtgatg gcatgtcttt tacgaatggc catcttatcc
    14401 aaattctcag caacaagagt aaaggcagcg gcatcggtat aatcacccgc cccctgaatc
    14461 agcccttcac gcaaaaacat ataatagtcg tgctcctgat tatcaacata ataccctcct
    14521 ataacaggag ttccacaggc caatgcctca ttcatcatcg tagaggcagg caatatggcg
    14581 acatctacag tactaaacaa gtctgcaatg gaaccggcag acaaattctt ctgataggtt
    14641 actttggggt catcaaccat attctcggct gcatacgaat caccgacaat tgccgttatc
    14701 ttcttcacat tgtccttggc tttaattgca tgaatggtct gatacgtcaa attcaagaaa
    14761 tcagaaccac caaaagccac caatacatat aaacctcctg aataattgtt ccgttgattc
    14821 tgcagcgcaa cattgaagaa aggcctcctc aacaatgaaa attgaagccc aaaggcaaat
    14881 tgagtatatg gttcacacga atagtcatca cgcgtgtaac ccaatccctg attgactata
    14941 agatcagcca catagtgctt gtcgtgcata tcatccacac acaccagaca gcaacctttt
    15001 tgcttgatgg cacgctggta atcagtagta aagaaatagt tgtcaagtac cacaatttcg
    15061 tcaccttgta aaagggaaag gaactcatca taatgtgatt cttcctgtaa ggggatgaaa
    15121 ggacatacct tctccatctc actcacctga taaggggtag gatggcaagt aaagaaggta
    15181 caatcaaaat cgtccttcag catatcggcc aaagccagag tacgaataaa gtgaccgtag
    15241 ccgatggcag cacttgcatc ggcacggaga tagattttct gcattacatc atttatgaag
    15301 caactcatac ttcatctctg ccaatgccca gtcagtctgt gtatcaaggt cctgcacttc
    15361 aagttcggaa agcaccaacc cggctgtatt ctcaccccaa aaagtccggc tctccacaaa
    15421 gggagcagtg cgagagaaat agaactgacc ggcatcgtga taaatcggtt ctaaatcttg
    15481 ggaacgtgca tttttgtatt cgggataaac catactaatt tttccatcca cgatgtgaag
    15541 gctgcgctgt ataggatagg aataagccac acaagtgaaa acggaatcta tctccgaatt
    15601 catttttccg tatgcttccc ggagtctttc gggagtgaca aaaggagccg ttgagtaaat
    15661 gcaacaaacc gtttcaaact ccctgccttg ctctttatac ttcctcagta cttcaagaat
    15721 tacatcatca gtaccggcat agtcatttga catctcggca ctccgcataa aaggaacttt
    15781 ggcaccatac ttacaagcta ttccggcaat ctcctcatca tcggtagaaa ccatcacctc
    15841 ctcaaaaaga ccgctttgta aagctgcctc tatggaatat gcaatgatag gtttacccat
    15901 aaagggcttg atattcttac gcggaatacg tttactgccg ccacgtgcag gaatgattgc
    15961 tatatttttc atttcgctac aaattctata accttttcaa tcacatactc ctgttcctcg
    16021 tccgtcagcg tgggatacat cggaagactc agacaatgtt cgtaatactc ttctactata
    16081 ggtaaatcgc ctttcctatt gccccactgc tgatagtaag gcatcagatg aagcggagca
    16141 taatgaacct gcgcatagac attgttctcg tgcagataat tataaagacc caagcggtca
    16201 gctacttgaa tgatataaag gtgataagca tgatagacat cggcagtatt gaacggagtc
    16261 ttgataccat ctattccgga aaacgcttca ttatagcgtc ttacgatttc atgacgacgt
    16321 tcaagacctg ctttcgcacg ctccagctga gaaataccca aggcagcctg aaaatcagtc
    16381 agacggtaat tataccctaa ctcctgcatc tcgtaatacc agccaccatg atgctcgtgc
    16441 aataaagcag ggtctttcgt aatgccatgc gtacggtaaa gacaaagctt gtcatagagc
    16501 tccttgctgt tggtggtcac catgcctccc tcacccgtag cgatatgttt cacgggatgg
    16561 aaagagaata cggcacagtc ggcaaaacaa ccgttaccac aatgttgttt cttgccttta
    16621 ctgtccatga aatagccgcc gggagcatgg caggcatcct cgataatcca caaaccgtac
    16681 tcgtcggcaa gctttctgaa ctcttccaga tccaaaggat agcctgcaaa atcaaccgga
    16741 acaatacctt tgtaagtacc gcgaggagaa gctttaagca tggcttcgag tttacggata
    16801 tccatgaggt aagtatcctt gtcaatatca cagaatacca cctcgccgcc acaatagcga
    16861 atgcagttgg cactggcagc aaaggtcatg ggagtgacaa tcaccttgtc acccggcttt
    16921 acattcagtg cggtagctgc aagatgaagc cccgaagtag cattgttcac cgctacggca
    16981 tattgtgcac ctacatattc ggcaaatttc gtttcaaatt ccctgatttt gggaccttgt
    17041 gtcaggtaat cgcttttcag ggtatcgatg actgcccgga tgtcctcatc tgtgatatgc
    17101 tgacgaccgt atggaatagg cttgcttatc atttcacctc gaaattaggg tcaacgtatt
    17161 tcttgatatt ctcgcgcata gtctctactg tctcccactc cgtattgttg tcactgctgt
    17221 agtggaaacc gtcgggaacg ggtactgcat tgtgatgtct gatgaactct tcgcgactgt
    17281 gcttgaaaga tacggaagga agaatgacat aatatctgcc caaatcgatt gtatcaagag
    17341 catcggttac agtaatcatc tcctcgtgca gtttctctcc cggacggatg cccacttcca
    17401 cctgcggcag attgggtgca atggcagtag ccacgtcctg gatatgatag gaaggaatct
    17461 taggaataaa gatttcacca cccaggtgat gtccgatggc atacatgacc aaagcgacac
    17521 cggcttccag tgaaatgttg aaacgggtca tgcgcatatc ggttatggga agttccttcg
    17581 ccccgttgtc acgcttgttg ataaagaaag ggattacgga accgcgggaa cccatcacat
    17641 tgccataacg gactacggag aacctgatgt ccttggaacc gctgatattg ttggcggcag
    17701 taaacagctt gtcggaagtg agcttggtgg cgccataaag attaatgggg gcacaagcct
    17761 tgtcagtaga aagggccacc acatgctgta caccggtggc aagagcagcc tttatcacat
    17821 tctgcgcacc gtgtacattg gttttgatgc actcttcggg attgtattca gcggtatcca
    17881 cctgcttgat ggcggctgca tggataatca cgtccactcc ttcgcaagcc cgcgtcaggc
    17941 gttcgaggtc acggacatca ccgataaaga aacgcagttg cggatactta tgaccgggat
    18001 atttctgttt cagctcaaat tgcttcagct catcgcggga gtaaataata attttcttta
    18061 cttgcggata atcacggaga atggtttcca caaacttctt tccgaaggaa cccgttcctc
    18121 cggtaatcaa tacggattta ttgttaagca ttatatgaaa agttttattc atcgatatat
    18181 tcccatggat agggattgtc tgtcacattc tgaaattcat caaccgcttc ctgctgttcg
    18241 ggagtaagtg ataaggaatc ccaggaggcg atgatggaac ggccttcgtc ggccaaagac
    18301 tcgtcgaaca cttcaccgta gcaggcggta agcagacgga gcttcagtaa ggaagcggga
    18361 agggcgtcga gcacatccca acaacagtcc agcacttcct ggacatgctg ctgcttttcg
    18421 ccatggtcca caaaagaggc gctgtaaccc ataagaaggg caagacagac atttgcctgc
    18481 tcttcgatgg tagtgccttt tacacccgac cggtataaag ccatggtaag acggtagacc
    18541 tcaccgttcc gccgtgacaa gtcatcgcta tagacgggac tgccgtccat acccaaatac
    18601 atcagttcgt gcgcagcacg ctgaagagtg attgcttctt cggaaagaga cataagcaat
    18661 tatagaatta agaattaaaa attaaagttc agccgattac ttctataaga tcgggatgga
    18721 tagtggccat ggcaacagct atgacacctt gtatttcgat aaccacgcga cggtcacgtg
    18781 cgcctttcac cttcagaaac acaccctctt gcccctcaaa ttcaccgccg gtaatccgga
    18841 ctttggtgcc tttggacaag ttcaattcat ccggttgaaa ataaagaaga tgatcatcgt
    18901 aagtgccgga tacggcaatg aaacgctgca tctgaccgtc tgggacaata atcttctgcc
    18961 cactgcgggt atcggtgata tattgcagat aagtgacttg agattttaca cgctgcacat
    19021 cggaaggacg ggcatggaca aaaagcagat tatgaacgac cggaaccaga gcacggactt
    19081 ttttcccttt ttttatacat atcttgtatt gcataggaat gaaacagccc aaattttctt
    19141 tcttgagcag atgcatggca tccggttctc tgcggtaggt ggcacgcata gcataccaga
    19201 tttcgacctc tttctctatt cccattttta tgcttttgtt cagacaaggg tgttctcctg
    19261 gggctttgaa cctcttgcat acacttgaaa ttcaattact tgcggacact ttatgtagaa
    19321 tacgacaagc tttatgccct tcttgtcaac agattttttg cagtcattca ttacctgtca
    19381 ggtaaaatgc tgtaaacgaa tctattgcaa gcaaaaagcg ttcaatagac gttcgttttt
    19441 tgaacgtcaa tatttaagaa aactaaagag ggaagattac ttaaaaatta gtaaaaggaa
    19501 gaagttagag aaatacaatg caataggctt actgacaaag tattatactc actaaaaaga
    19561 aatttataga atatttttat taaacatttt gcgagattca aaaatacacg ttatctttgc
    19621 gttcattaaa cgaacgttta aaaaacacct tttccaaacg aaatattcca ctgtataaca
    19681 aataattaca ttgaaataaa aaatatcgtg tttatagaaa tcagattcct acaaacacga
    19741 tatcaattaa aaaagaaatt actattctca gaagttaaag atacccaatt ccgggaaagt
    19801 agccccttgc actgcaaaac agattccgaa gcaagccgca cttacaatcc aaagaataac
    19861 cagcgtccac ttcaaaccgg aattcatcgg ctgccatttg aatatctgac tgaagatggc
    19921 ccatacaaga ctgaccaaag gaattcctac cagcaagatt cctgcaatgt acatcacaat
    19981 ggcagacaac ggagaagtag gcagtaccac atcagccatc gggaaaaagg aaatgagagc
    20041 cgcaccgcca ccaacagcca ccgctatcgc agcaaacaac aacgccacaa ataccactcc
    20101 aaatacaaac agtaccggac tgcagataat ggcaaatatc accagacaga ttttcaagaa
    20161 ccagccgaca atcatcacca atgcatctcc caacttctgc aagaaagtac ggggtttgtc
    20221 cgacctcata taatcattca ccccattggc aaccttctca aaaccgtccg tcaccgtctt
    20281 tccgatattc tctaccgtaa cggcctcgcc acgcatactc aacttctcgg ctgctgtgcg
    20341 ggcttccggt ataaccagcc aacacacgat atagaccggt atcaatgtcc ctaccccaca
    20401 aatcaagatg acaagcagta acagtcgaag taaagttaca tcccatccca ggtaggcagc
    20461 cattccactg atgacaccac ccagcatttt gtcatccgga ttgcggtata gacgacggcg
    20521 tgtagtgcca taagcggtat tgctgttcca agcaccggca ccatagccgc ccccggcact
    20581 cgtgctgccg gaatcggcac tagcactctc tccttctgcc tccatatctt ccggctttcc
    20641 catgcgggca atcacctctt ccacgtcggc tatcgtgatt acttgtgaac cggccgacaa
    20701 tttctcggca aagagttcgg aaatacggcg ttcaatatca tctacaatct cgtcggcacc
    20761 ggcttccttg cggaagtgca tcttgagatt actcagataa ttatccaaaa gacggtatgc
    20821 gtcatcatca atattgaaaa cggttccacc taaatttaca gttaatgtct ttttcataac
    20881 acattattta tttacaattt tactatttac gatttaccat ccggcgaatt acggtatatt
    20941 ctcttcagct atttcaagaa ttgctgatgt gattcaccgt ctcgttcaac tctttccagg
    21001 atgtttccag ttcaccgaga aagacttctc ctttttccgt caaccggtaa tatttacggg
    21061 gaggcccttg tgtagactca atccattcat accccaaaag gtcgtcgttc ttcaaacggg
    21121 tgagcaacgg ataaagtgta ccttccacca caatcagtct ggcttctttc aacttctgaa
    21181 tgatatccga agcataagcc ggctctttgt gaagcagcag catgatgcaa tattcaagca
    21241 tgcccttgcg catttgcgac tttacattgt ttacatccat aatggtattt actatttgac
    21301 aatttactat ttggctgcgc aatagagtaa tgagtgtcct tattaattct attgttgttc
    21361 cttgtatggc acaaatatat gtattatacc agtaccttgc attacaaagt actttatatt
    21421 aaacattatt aacaagaaaa gtagttcaca ctactctata acatcagtaa cgtgaacaga
    21481 gagggaaagg gatatttacc gatagataac aattttatcc aatataccgg tcagactcgc
    21541 aattgctact ccgtagttgg ttatggggat gtgctgtgcg cgggcatgga ctatacgatt
    21601 gagaacgtac ttccggttga acatgcaagc gccgcaatgg ataattaaat catatcggga
    21661 caagtctttg ggaaagtcat ttccagatac aaagtctatc tgcaattcct cgccgatgcg
    21721 ctttcgtaac aggcggggaa ttttgacggt gccgatgtcc tcggtcagcg gggcgtgggt
    21781 gcaggcttcg gctatcagta cacgcgattg gggtgtcaga ctatgaatag cggcagctcc
    21841 ctctacaaag acattgatgt ctcctttgta accggcaaaa agaaccgaga aggaagtaag
    21901 actactttcg gcaggctttt gttgatagac gatggggaat acttgtgaat cggtgattat
    21961 cagcttaggc ggacggacaa gggcttgcag ggaggcttgc agcttatcgg tggtgcaact
    22021 catcactaag cactttttat ccaacagttc gcggatggtc tgcacttgcg gaagaatgag
    22081 acgacctttg ggggcttgta tatcctgggg catcaccagc aggacgacat ct
//
