LOCUS       gnlProkkaCJGPPNMC_351  20147 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CJGPPNMC_351.
ACCESSION   gnlProkkaCJGPPNMC_351
VERSION     gnlProkkaCJGPPNMC_351
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 03:14:46
            Original ID  :: gnl|Prokka|CJGPPNMC_351
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 20147
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20147
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3240:18276]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3241..18276
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..20147
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..20147
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(20..112)
                     /locus_tag="ctg351_1"
                     /transl_table=11
                     /translation="MPMDREIQEMGGSVEAKQMQIYVSATRLKF"
     CDS             278..394
                     /locus_tag="ctg351_2"
                     /transl_table=11
                     /translation="MNNARLMSFKLLYNTFAPCAQQVWVTYFICKSLGVSDA"
     CDS             complement(602..784)
                     /locus_tag="ctg351_3"
                     /transl_table=11
                     /translation="MRDSKIHVIFAFIKRTFKKHLIISNISFYIPTSYPHKCIIEVSQR
                     CLLINGNLSHKTQVK"
     CDS             complement(818..1039)
                     /locus_tag="ctg351_4"
                     /transl_table=11
                     /translation="MPFLSTDFLQSFITCQVKCCKRIYCKQKAFNRRSFFERQYLRKLK
                     REDYLKISKRKKLEKYNAIGLLTKYYTH"
     CDS             1148..1684
                     /locus_tag="ctg351_5"
                     /transl_table=11
                     /translation="MGIEKEVEIWYAMRATYRREPDAMHLLKKENLGCFIPMQYKICIK
                     KGKKVRALVPVVHNLLFVHARPSDVQRVKSQVTYLQYITDTRSGQKIIVPDGQMQRFIA
                     VSGTYDDHLLYFQPDELNLSKGTKVRITGGEFEGQEGVFLKVKGARDRRVVIEIQGVIA
                     VAMATIHPDLIEVIG"
     CDS             1720..2208
                     /locus_tag="ctg351_6"
                     /transl_table=11
                     /translation="MSLSEEAITLQRAAHELMYLGMDGSPVYSDDLSRRNGEVYRLTMA
                     LYRSGVKGTTIEEQANVCLALLMGYSASFVDHGEKQQHVQEVLDCCWDVLDALPASLLK
                     LRLLTACYGEVFDESLADEGRSIIASWDSLSLTPEQQEAVDEFQNVTDNPYPWEYIDE"
     CDS             2222..3244
                     /NRPS_PKS="Domain: NAD_binding_4 (8-133). E-value: 6.5e-14.
                     Score: 43.5. Matches aSDomain:
                     nrpspksdomains_ctg351_7_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg351_7"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3.2e-97,
                     bitscore: 316.2, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.6e-15, bitscore:
                     47.3, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.7e-14, bitscore:
                     43.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNNKSVLITGGTGSFGKKFVETILRDYPQVKKIIIYSRDELKQF
                     ELKQKYPGHKYPQLRFFIGDVRDLERLTRACEGVDVIIHAAAIKQVDTAEYNPEECIKT
                     NVHGAQNVIKAALATGVQHVVALSTDKACAPINLYGATKLTSDKLFTAANNISGSKDIR
                     FSVVRYGNVMGSRGSVIPFFINKRDNGAKELPITDMRMTRFNISLEAGVALVMYAIGHH
                     LGGEIFIPKIPSYHIQDVATAIAPNLPQVEVGIRPGEKLHEEMITVTDALDTIDLGRYY
                     VILPSVSFKHSREEFIRHHNAVPVPDGFHYSSDNNTEWETVETMRENIKKYVDPNFEVK
                     "
     CDS_motif       2237..2284
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg351_7_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg351_7"
                     /protein_end="21"
                     /protein_start="5"
                     /score="11.0"
                     /tool="antismash"
                     /translation="SVLITGGTGSFGKKFV"
     aSDomain        2246..2620
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg351_7_NAD_binding_4.1"
                     /evalue="6.50E-14"
                     /label="ctg351_7_NAD_binding_4.1"
                     /locus_tag="ctg351_7"
                     /protein_end="133"
                     /protein_start="8"
                     /score="43.5"
                     /tool="antismash"
                     /translation="ITGGTGSFGKKFVETILRDYPQVKKIIIYSRDELKQFELKQKYPG
                     HKYPQLRFFIGDVRDLERLTRACEGVDVIIHAAAIKQVDTAEYNPEECIKTNVHGAQNV
                     IKAALATGVQHVVALSTDKAC"
     CDS             3241..4404
                     /NRPS_PKS="Domain: Aminotran_1_2 (35-167). E-value:
                     1.3e-13. Score: 42.6. Matches aSDomain:
                     nrpspksdomains_ctg351_8_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     330.2; E-value: 2.8e-100)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg351_8"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.4e-113,
                     bitscore: 368.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.5e-14, bitscore:
                     42.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISKPIPYGRQHITDEDIRAVIDTLKSDYLTQGPKIREFETKFAE
                     YVGAQYAVAVNNATSGLHLAATALNVKPGDKVIVTPMTFAASANCIRYCGGEVVFCDID
                     KDTYLMDIRKLEAMLKASPRGTYKGIVPVDFAGYPLDLEEFRKLADEYGLWIIEDACHA
                     PGGYFMDSKGKKQHCGNGCFADCAVFSFHPVKHIATGEGGMVTTNSKELYDKLCLYRTH
                     GITKDPALLHEHHGGWYYEMQELGYNYRLTDFQAALGISQLERAKAGLERRHEIVRRYN
                     EAFSGIDGIKTPFNTADVYHAYHLYIIQVADRLGLYNYLHENNVYAQVHYAPLHLMPYY
                     QQWGNRKGDLPIVEEYYEHCLSLPMYPTLTDEEQEYVIEKVIEFVAK"
     aSDomain        3346..3741
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg351_8_Aminotran_1_2.1"
                     /evalue="1.30E-13"
                     /label="ctg351_8_Aminotran_1_2.1"
                     /locus_tag="ctg351_8"
                     /protein_end="167"
                     /protein_start="35"
                     /score="42.6"
                     /tool="antismash"
                     /translation="IREFETKFAEYVGAQYAVAVNNATSGLHLAATALNVKPGDKVIVT
                     PMTFAASANCIRYCGGEVVFCDIDKDTYLMDIRKLEAMLKASPRGTYKGIVPVDFAGYP
                     LDLEEFRKLADEYGLWIIEDACHAPGGY"
     CDS             4401..5084
                     /locus_tag="ctg351_9"
                     /transl_table=11
                     /translation="MKNIAIIPARGGSKRIPRKNIKPFMGKPIIAYSIEAALQSGLFEE
                     VMVSTDDEEIAGIACKYGAKVPFMRSAEMSNDYAGTDDVILEVLRKYKEQGREFETVCC
                     IYSTAPFVTPERLREAYGKMNSEIDSVFTCVAYSYPIQRSLHIVDGKISMVYPEYKNAR
                     SQDLEPIYHDAGQFYFSRTAPFVESRTFWGENTAGLVLSELEVQDLDTQTDWALAEMKY
                     ELLHK"
     CDS             5065..6066
                     /locus_tag="ctg351_10"
                     /transl_table=11
                     /translation="MSCFINDVMQKIYLRADASAAIGYGHFIRTLALADMLKDDFDCTF
                     FTCHPTPYQVSEMEKVCPFIPLQEESHYDEFLSLLQGDEIVVLDNYFFTTDYQRAIKQK
                     GCCLVCVDDMHDKHYVADLIVNQGLGYTRDDYSCEPYTQFAFGLQFSLLRRPFFNVALQ
                     NQRNNYSGGLYVLVAFGGSDFLNLTYQTIHAIKAKDNVKKITAIVGDSYAAENMVDDPK
                     VTYQKNLSAGSIADLFSTVDVAILPASTMMNEALACGTPVIGGYYVDNQEHDYYMFLRE
                     GLIQGAGDYTDAAAFTLVAENLDKMAIRKRHAITPDIPKRFVNLFKSLLICK"
     CDS             6057..6512
                     /locus_tag="ctg351_11"
                     /transl_table=11
                     /translation="MQVTSQRASAILYNYLSGNHFDKPFLLPANVCPVVPLSFMKAGVG
                     FEFIDIDESHAMSTEKCLTAIEAGKYSGLVFVHAYGKKYDNKEFYRAVKSLDPNLCIID
                     DCCLCIPELADSLPENVDLCLYSTGYAKFIELSYGGYASFRGGVRSC"
     CDS             6469..6993
                     /locus_tag="ctg351_12"
                     /transl_table=11
                     /translation="MVAMQVLGGGYEVVDYQYDSISEQKHSVYIRKCLLENVRYMLPAD
                     YPWLDASNLQMTDEEYFDIIERKLPKVIAEKEKINKIYRNLLPESIQMGDDFQNWRFMI
                     VIENRQKVLDAIFKAGLFAGTNFPSVSYMFKGVSSPVAEVEAKHIVNLFNDFRFSEAQA
                     RKICDVINSVI"
     CDS             6990..8129
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 60.5; E-value: 2.7e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg351_13"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.9e-15, bitscore:
                     47.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4e-12, bitscore:
                     37.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLLILGAGEMQVPVIRKANDMGLHTIVADMDANAPGMGYASE
                     PVLVSTMDKEGVLECAKRHSVDGILTTSDAPVNVVSYVGEQLGLPSMSTEVAKICTNKY
                     LQREMFAANGIDVPFFMLCDKDTDLGTLQDYPYIVKPVDSSASRGVKKVTNHKELVLAF
                     SEALGYSRTGKAIVEGFITGREFSVETYTQNNKTTVVTITEKLCIGEAEGFFVEDTHIE
                     PARITKQEWELVSETVSKALCLIGLNNCPSHTEIKLNESGAYIIEIACRLGGDYITSDL
                     VPLSTGIDMLRNLVNCSLGLPVDVLRKHEKCSAVQFLNPLNYQRCVDFLSSSRSSAVFR
                     SEIRPYSEKKIKNSLDRLGYIILQTDSMEELESILRTIK"
     CDS             8137..9153
                     /locus_tag="ctg351_14"
                     /transl_table=11
                     /translation="MRDKCMIVAEMSANHNGKKETAIETVRAAKRAGADAVKLQTYRAD
                     TITLRCDKPDFIINEGSIWDGQYFYDLYEQAYTPWEWHEELFHVAKEEGLICFSSPFDK
                     TAVDMLEALDCPVYKIASFEITDIPLIEYAASKHKPMVLATGIATEEDIQLAVEACRRM
                     GNNDITVLKCTSSYPAPVEEANLCMIRDLAERFQVKSGLSDHTLGSVSPIVAVTQGASM
                     IEKHFILNRSIGGPDCSFSMEEKDFAQMVKDVRMAELSLGKTTYELTEKMRGSRSASRS
                     LYVAEDMKAGEVITERNVRSVRPGFGLHPKYLKDILGKNVNRDLEKGTRFALEYVNG"
     CDS             9498..9671
                     /locus_tag="ctg351_15"
                     /transl_table=11
                     /translation="MAVVIEAMRTYFFQRAAAVYFAVAGQIEMIADVTEAAVVDVVAAA
                     ILKAQGHALRRG"
     CDS             complement(9861..10346)
                     /locus_tag="ctg351_16"
                     /transl_table=11
                     /translation="MIRYKKYQVTGEDSPLKGLWYARPVIEETFDIEKLAKHMSNHNTP
                     YSSGVIKGVLADMVSCTKELILDGKNVKLDDLAIFSVGIVSKKGAQSAADFSLANNVKG
                     LKLRARATGELSNAQINLDGQLKESSLYTVGGKAPDGSGSDGGSGGSDGNQGENPLG"
     CDS             10895..11161
                     /locus_tag="ctg351_17"
                     /transl_table=11
                     /translation="MSDFWFPVVSLAIYIFHQPVFLHTFEPGGGGFRFDAHLSGFLQER
                     GPCEFFFHAVYQCIPVGIAAACHFGVGQEGEDMGGMPIKAFGQ"
     CDS             11447..11647
                     /locus_tag="ctg351_18"
                     /transl_table=11
                     /translation="MKGEYSVHDNGFQFVLPFHAQSLEGIFKIAVIAVELVLPMMYGRH
                     VVEYLARKEPVLSSGNQWFHL"
     CDS             11702..12079
                     /locus_tag="ctg351_19"
                     /transl_table=11
                     /translation="MVGAPVVGQSVVVEGFAHGVAPVSVFRTDGGGDGVGFAFAYQSGT
                     VGVHQVLQDAGSGVVARDEEHLVERHYGSLRFSTFLAQCVVFCFFAAVTCHAFVYLPTY
                     FIVNGLGKQAYQGEHSFAGCR"
     CDS             complement(12529..12720)
                     /locus_tag="ctg351_20"
                     /transl_table=11
                     /translation="MQITDYKLLIINYQIRWNHYLHCTFWPKQSEMQEQTLLQPIKNIY
                     NWHLPLPPTAEKQDGMIF"
     CDS             complement(12725..13357)
                     /locus_tag="ctg351_21"
                     /transl_table=11
                     /translation="MPKSFKMSLFMPPISPMKDGATRKIVKSATLTPLRTLELNEVYQL
                     ITANKRLITLTQAIREAALQGDDNNCRMLKQQTLPYVTPCGVFTRRRSDCLKLPSGLVV
                     VDVDHLDSPDEAGRLKQLLFKDPYLAPVLVFISPTGRGVKAFVPCPIGKDSTEAVRWAM
                     NYVHCMYDAENTQPGKGVDTSGKDLVRACFLCHDPKALLRKVVNFEL"
     CDS             13502..13642
                     /locus_tag="ctg351_22"
                     /transl_table=11
                     /translation="MGKNFIHPSLGFFIERTRKQSGVTIETLCKDLHISPSTYIDLKKR
                     V"
     CDS             13585..13794
                     /locus_tag="ctg351_23"
                     /transl_table=11
                     /translation="MQGFAYFSIHVHRLKKKGVTPHLVHTKLFCDTISMNWRNWMMTKS
                     GNWLGNGWKNGWRLGRRGSGDWIG"
     CDS             13826..13927
                     /locus_tag="ctg351_24"
                     /transl_table=11
                     /translation="MINFTVGPVQSSDAVRVIGAEQVPYLEQQSFQK"
     CDS             13924..14676
                     /NRPS_PKS="Domain: Aminotran_5 (3-189). E-value: 1.1e-20.
                     Score: 65.7. Matches aSDomain:
                     nrpspksdomains_ctg351_25_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg351_25"
                     /sec_met_domain="Aminotran_5 (E-value: 2.8e-18, bitscore:
                     57.0, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDK
                     ALVINGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETF
                     TGVHYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIA
                     VMLLAPSAIKRIEKVQCCCQYLDLKLALKNMERGQTPCTPAVGILRQINVRLKEIESAG
                     GAEVEIARCAELAKYFRDKLVKNNLPLF"
     aSDomain        13933..14490
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg351_25_Aminotran_5.1"
                     /evalue="1.10E-20"
                     /label="ctg351_25_Aminotran_5.1"
                     /locus_tag="ctg351_25"
                     /protein_end="189"
                     /protein_start="3"
                     /score="65.7"
                     /tool="antismash"
                     /translation="ENERLVKKFANATKDSKVVFMTCSGSGGMEAAIINCLTPQDKALV
                     INGGSFGERFVELLTLHKIPFTEIKLKYGRALKPEHLAEYESKGYTTFLMQKHETFTGV
                     HYDINLVSDFCKRNNCFLIVDIISTFLCDSFDMVAMDVGVMITGSQKALACAPGIAVML
                     LAPSAIKRIEKVQCCCQYLDLKL"
     CDS             14673..15047
                     /locus_tag="ctg351_26"
                     /transl_table=11
                     /translation="MTYRQVGTNSFTVKYYVEKFILDMNTMKIIRVDEYRDKKKINRPA
                     GSLFSVDGEIYRVAQKCSRAYGESIFVYKTSKNFDFIKDKKVAELTGQSIVLSDGRKPI
                     LLHTYSQAGGIEVIDYRCSL"
     CDS             15072..16382
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 190.9;
                     E-value: 4.6e-58)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg351_27"
                     /sec_met_domain="CTP_transf_like (E-value: 3.3e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.8e-114, bitscore:
                     371.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.3e-61, bitscore:
                     198.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTVYLGMIGDIMHPGYINIINKATEYGDVIIGLFTDKAIANHR
                     RLPYLTWEQRKNVVESIRNVSRVVPQDDWSYVSNLLKYKPDYIIHGDDWQVGPDKYIRD
                     EVFKVMEKLGGEVIEIPYTQNISASGIKQEIDALGVTPQMRLSSLRRLIAAKPIVRILE
                     SHNGLTGLIAEHTKVEVNGQEREFDGMWASSLTDSTSKGKPDIEAVDLTTRLHDLNDTL
                     EVTTKPVIFDGDTGGKIEHFGFTVRTLERLGISCVIIEDKVGLKQNSLFGTDAVQTQDT
                     IEGFQAKIRAGKEAQITRDFMIVSRCESLIAGKTVDDALERCHAYVEAGTDGIMIHSKE
                     KSGEDIKEFCLRFREKNAHTPIIVVPTTYNQFTEEELAEWGINVVIYANHMLRSAYPAM
                     VKCAETILYTSRSLEASEQYCMPIKQILNLIPGTKKK"
     CDS             16417..17544
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 74.7;
                     E-value: 1.1e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg351_28"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.6e-20, bitscore:
                     63.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1e-23, bitscore:
                     74.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRPEFFVNILKEQGIDFYAGVPDSLLKNICAYITDHLPAEQNII
                     AANEGGAMGIAVGYHLATGKVPVVYMQNSGEGNIINPFASLTDKDVYNIPVLLVIGWRG
                     RPGVHDEPQHVKQGKVTIGLLNTMGINYAILPKDEEGAAKQIKIAVDFMKATNECYALV
                     IEKDTFDTYKLQSVEVNELAMSREETIQKVASNIEDNACIVSTTGMISRELFEARTAWS
                     QGHERDFLTVGAMGHASQIALGIALQKPERRVYCFDGDGASIMHMGNMAITASMKCKNY
                     VHIVFNNGAHDSVGGQPTVGLKIDFCAIAQAVGYKAAYSVETMEALEAKLAEFKNAEGP
                     VFLQICVKKGNRKDLGRPTTTPIQNKEAFMEFLNK"
     CDS             17548..18276
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Metallophos_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg351_29"
                     /sec_met_domain="Metallophos_2 (E-value: 1.2e-27, bitscore:
                     88.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVILFADIHANLSAFEAVLADIEKHYQPDAMISLGDFIDYGMRS
                     NEIIERIQTVNIPLLANLKGNHEKALIDGELSCFSSERARVMSKYTRNHLTQTSIDYIS
                     NVMQEPMQELEIGGKKVLLLHGTIDDPYWGKLTPAKVEDEKYQDFDYVLSGHIHQPFKI
                     DVFFKVDNPIMRNQKRTTFINPGSVGQPRNQNPYAQYVYINFKTGETHFNAVPYDIEAE
                     QSLFPKEIDTFYSERLKFGI"
     CDS             18277..19272
                     /NRPS_PKS="Domain: NAD_binding_4 (83-198). E-value:
                     6.4e-10. Score: 30.4. Matches aSDomain:
                     nrpspksdomains_ctg351_30_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     143.1; E-value: 2.2e-43)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg351_30"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.7e-09,
                     bitscore: 27.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9.3e-09, bitscore:
                     25.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNLYVISGVTGMTGSELSRQFVSQGHTVIGFDNFFASSIDTVKD
                     IIDNPSFIFYNYDINKVAQMDEVCDKAKELKIECDGRLVFINCAAVVHTKHFYEVESTF
                     QTNVLAMKDFLERAISMRADTYINCSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRT
                     SYACGKLMTEFFMKDAVGKGRIKGCSIRFANVYSRHERFAEHIIPHIIDNLLESHTVTL
                     LENSKVNKRTFLHNIDSCRAVMELIASEDALDGTVYNVATEEEIAIIDLVKTIAIKMGI
                     NDVDIRFEGYRKSDPERRLLNTDKIRTRTSWKPIITLDEGLTMCVNSIKK"
     aSDomain        18526..18870
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg351_30_NAD_binding_4.1"
                     /evalue="6.40E-10"
                     /label="ctg351_30_NAD_binding_4.1"
                     /locus_tag="ctg351_30"
                     /protein_end="198"
                     /protein_start="83"
                     /score="30.4"
                     /tool="antismash"
                     /translation="VFINCAAVVHTKHFYEVESTFQTNVLAMKDFLERAISMRADTYIN
                     CSTSEVYSMQSWNENGGVKESDYLAMSTAEHSQRTSYACGKLMTEFFMKDAVGKGRIKG
                     CSIRFANVYSR"
     CDS             19269..20009
                     /locus_tag="ctg351_31"
                     /transl_table=11
                     /translation="MKYLIITVAGTATRFNRDTKEETLKCLYYTDEPQYALLAQLLKNC
                     GEYDKYILVGGYLYEKLGRFVKNELSGYGKKKELVYNEHFKDYGSGYSLYKGIEAIKEA
                     GDVTFVEGDLFFMATDFRQVYNSPKSVITINREPIYSNKAVALYINVDGKPRYLYDTNH
                     QTLTVSEPFKAIFNSGQMWKFSSSERLLKTVDSLTKEQLQGTNLEIIQAYFSDMNSEEY
                     DVVTFTDWFNCNTVADYDIVRKLM"
     CDS             20012..20146
                     /locus_tag="ctg351_32"
                     /transl_table=11
                     /translation="MNMAVLERDYRIDGIKWLLIVLVTFGHVIEPALSNPIANKLYSII
                     "
ORIGIN
        1 cctttgtact acatcttttt taaaacttaa ggcgtgttgc tgaaacataa atttgcatct
       61 gctttgcttc cacacttcca cccatctcct gtatctccct atccatcggc atttaccctg
      121 cggtggaagc aacctgaaaa ggtggaagca aaatttgctt ccacctgcca aaaacgtctg
      181 agttttgccg taacttatta ttttctaata taataccgcg cgtgggttac ataaatcggt
      241 cggtgtagtt ttcctgcatt ttcgagtttg cccgactatg aataatgccc gtctaatgtc
      301 ttttaagtta ctgtacaata cgtttgcgcc ttgtgcgcaa caagtgtggg ttacgtactt
      361 catctgtaaa agccttggag ttagtgacgc ctaacggcca tgaacaaccc tgcttatggt
      421 cgttaaacga ttgcttcatg gccgttagca ggggtgttca tggccgttag gcgttattaa
      481 ttccttatgc aacagtagac caagcaaggg tgaaaagcaa aggaatgctt gtgttttaga
      541 tagaaatcca cgggctttca ctctcttttc atagattata atagattata gaagtgggct
      601 tttatttcac ttgcgttttg tgcgataaat tcccatttat cagcaggcat ctttgcgaaa
      661 cttcaataat gcatttatga gggtaagatg ttggaatgta gaatgatata ttggaaatga
      721 tgaggtgttt tttaaacgtt cgtttaatga acgcaaagat aacgtgtatt tttgaatctc
      781 gcaaaatgtt taataaaaat attctataaa tttcttttta gtgagtataa tactttgtca
      841 gtaagcctat tgcattgtat ttctctaact tcttcctttt actaattttt aagtaatctt
      901 ccctctttag ttttcttaaa tattgacgtt caaaaaacga acgtctattg aacgcttttt
      961 gcttgcaata gattcgttta cagcatttta cctgacaggt aatgaatgac tgcaaaaaat
     1021 ctgttgacaa gaagggcata aagcttgtcg tattctacat aaagtgtccg caagtaattg
     1081 aatttcaagt gtatgcaaga ggttcaaagc cccaggagaa cacccttgtc tgaacaaaag
     1141 cataaaaatg ggaatagaga aagaggtcga aatctggtat gctatgcgtg ccacctaccg
     1201 cagagaaccg gatgccatgc atctgctcaa gaaagaaaat ttgggctgtt tcattcctat
     1261 gcaatacaag atatgtataa aaaaagggaa aaaagtccgt gctctggttc cggtcgttca
     1321 taatctgctt tttgtccatg cccgtccttc cgatgtgcag cgtgtaaaat ctcaagtcac
     1381 ttatctgcaa tatatcaccg atacccgcag tgggcagaag attattgtcc cagacggtca
     1441 gatgcagcgt ttcattgccg tatccggcac ttacgatgat catcttcttt attttcaacc
     1501 ggatgaattg aacttgtcca aaggcaccaa agtccggatt accggcggtg aatttgaggg
     1561 gcaagagggt gtgtttctga aggtgaaagg cgcacgtgac cgtcgcgtgg ttatcgaaat
     1621 acaaggtgtc atagctgttg ccatggccac tatccatccc gatcttatag aagtaatcgg
     1681 ctgaacttta atttttaatt cttaattcta taattgctta tgtctctttc cgaagaagca
     1741 atcactcttc agcgtgctgc gcacgaactg atgtatttgg gtatggacgg cagtcccgtc
     1801 tatagcgatg acttgtcacg gcggaacggt gaggtctacc gtcttaccat ggctttatac
     1861 cggtcgggtg taaaaggcac taccatcgaa gagcaggcaa atgtctgtct tgcccttctt
     1921 atgggttaca gcgcctcttt tgtggaccat ggcgaaaagc agcagcatgt ccaggaagtg
     1981 ctggactgtt gttgggatgt gctcgacgcc cttcccgctt ccttactgaa gctccgtctg
     2041 cttaccgcct gctacggtga agtgttcgac gagtctttgg ccgacgaagg ccgttccatc
     2101 atcgcctcct gggattcctt atcacttact cccgaacagc aggaagcggt tgatgaattt
     2161 cagaatgtga cagacaatcc ctatccatgg gaatatatcg atgaataaaa cttttcatat
     2221 aatgcttaac aataaatccg tattgattac cggaggaacg ggttccttcg gaaagaagtt
     2281 tgtggaaacc attctccgtg attatccgca agtaaagaaa attattattt actcccgcga
     2341 tgagctgaag caatttgagc tgaaacagaa atatcccggt cataagtatc cgcaactgcg
     2401 tttctttatc ggtgatgtcc gtgacctcga acgcctgacg cgggcttgcg aaggagtgga
     2461 cgtgattatc catgcagccg ccatcaagca ggtggatacc gctgaataca atcccgaaga
     2521 gtgcatcaaa accaatgtac acggtgcgca gaatgtgata aaggctgctc ttgccaccgg
     2581 tgtacagcat gtggtggccc tttctactga caaggcttgt gcccccatta atctttatgg
     2641 cgccaccaag ctcacttccg acaagctgtt tactgccgcc aacaatatca gcggttccaa
     2701 ggacatcagg ttctccgtag tccgttatgg caatgtgatg ggttcccgcg gttccgtaat
     2761 ccctttcttt atcaacaagc gtgacaacgg ggcgaaggaa cttcccataa ccgatatgcg
     2821 catgacccgt ttcaacattt cactggaagc cggtgtcgct ttggtcatgt atgccatcgg
     2881 acatcacctg ggtggtgaaa tctttattcc taagattcct tcctatcata tccaggacgt
     2941 ggctactgcc attgcaccca atctgccgca ggtggaagtg ggcatccgtc cgggagagaa
     3001 actgcacgag gagatgatta ctgtaaccga tgctcttgat acaatcgatt tgggcagata
     3061 ttatgtcatt cttccttccg tatctttcaa gcacagtcgc gaagagttca tcagacatca
     3121 caatgcagta cccgttcccg acggtttcca ctacagcagt gacaacaata cggagtggga
     3181 gacagtagag actatgcgcg agaatatcaa gaaatacgtt gaccctaatt tcgaggtgaa
     3241 atgataagca agcctattcc atacggtcgt cagcatatca cagatgagga catccgggca
     3301 gtcatcgata ccctgaaaag cgattacctg acacaaggtc ccaaaatcag ggaatttgaa
     3361 acgaaatttg ccgaatatgt aggtgcacaa tatgccgtag cggtgaacaa tgctacttcg
     3421 gggcttcatc ttgcagctac cgcactgaat gtaaagccgg gtgacaaggt gattgtcact
     3481 cccatgacct ttgctgccag tgccaactgc attcgctatt gtggcggcga ggtggtattc
     3541 tgtgatattg acaaggatac ttacctcatg gatatccgta aactcgaagc catgcttaaa
     3601 gcttctcctc gcggtactta caaaggtatt gttccggttg attttgcagg ctatcctttg
     3661 gatctggaag agttcagaaa gcttgccgac gagtacggtt tgtggattat cgaggatgcc
     3721 tgccatgctc ccggcggcta tttcatggac agtaaaggca agaaacaaca ttgtggtaac
     3781 ggttgttttg ccgactgtgc cgtattctct ttccatcccg tgaaacatat cgctacgggt
     3841 gagggaggca tggtgaccac caacagcaag gagctctatg acaagctttg tctttaccgt
     3901 acgcatggca ttacgaaaga ccctgcttta ttgcacgagc atcatggtgg ctggtattac
     3961 gagatgcagg agttagggta taattaccgt ctgactgatt ttcaggctgc cttgggtatt
     4021 tctcagctgg agcgtgcgaa agcaggtctt gaacgtcgtc atgaaatcgt aagacgctat
     4081 aatgaagcgt tttccggaat agatggtatc aagactccgt tcaatactgc cgatgtctat
     4141 catgcttatc acctttatat cattcaagta gctgaccgct tgggtcttta taattatctg
     4201 cacgagaaca atgtctatgc gcaggttcat tatgctccgc ttcatctgat gccttactat
     4261 cagcagtggg gcaataggaa aggcgattta cctatagtag aagagtatta cgaacattgt
     4321 ctgagtcttc cgatgtatcc cacgctgacg gacgaggaac aggagtatgt gattgaaaag
     4381 gttatagaat ttgtagcgaa atgaaaaata tagcaatcat tcctgcacgt ggcggcagta
     4441 aacgtattcc gcgtaagaat atcaagccct ttatgggtaa acctatcatt gcatattcca
     4501 tagaggcagc tttacaaagc ggtctttttg aggaggtgat ggtttctacc gatgatgagg
     4561 agattgccgg aatagcttgt aagtatggtg ccaaagttcc ttttatgcgg agtgccgaga
     4621 tgtcaaatga ctatgccggt actgatgatg taattcttga agtactgagg aagtataaag
     4681 agcaaggcag ggagtttgaa acggtttgtt gcatttactc aacggctcct tttgtcactc
     4741 ccgaaagact ccgggaagca tacggaaaaa tgaattcgga gatagattcc gttttcactt
     4801 gtgtggctta ttcctatcct atacagcgca gccttcacat cgtggatgga aaaattagta
     4861 tggtttatcc cgaatacaaa aatgcacgtt cccaagattt agaaccgatt tatcacgatg
     4921 ccggtcagtt ctatttctct cgcactgctc cctttgtgga gagccggact ttttggggtg
     4981 agaatacagc cgggttggtg ctttccgaac ttgaagtgca ggaccttgat acacagactg
     5041 actgggcatt ggcagagatg aagtatgagt tgcttcataa atgatgtaat gcagaaaatc
     5101 tatctccgtg ccgatgcaag tgctgccatc ggctacggtc actttattcg tactctggct
     5161 ttggccgata tgctgaagga cgattttgat tgtaccttct ttacttgcca tcctacccct
     5221 tatcaggtga gtgagatgga gaaggtatgt cctttcatcc ccttacagga agaatcacat
     5281 tatgatgagt tcctttccct tttacaaggt gacgaaattg tggtacttga caactatttc
     5341 tttactactg attaccagcg tgccatcaag caaaaaggtt gctgtctggt gtgtgtggat
     5401 gatatgcacg acaagcacta tgtggctgat cttatagtca atcagggatt gggttacacg
     5461 cgtgatgact attcgtgtga accatatact caatttgcct ttgggcttca attttcattg
     5521 ttgaggaggc ctttcttcaa tgttgcgctg cagaatcaac ggaacaatta ttcaggaggt
     5581 ttatatgtat tggtggcttt tggtggttct gatttcttga atttgacgta tcagaccatt
     5641 catgcaatta aagccaagga caatgtgaag aagataacgg caattgtcgg tgattcgtat
     5701 gcagccgaga atatggttga tgaccccaaa gtaacctatc agaagaattt gtctgccggt
     5761 tccattgcag acttgtttag tactgtagat gtcgccatat tgcctgcctc tacgatgatg
     5821 aatgaggcat tggcctgtgg aactcctgtt ataggagggt attatgttga taatcaggag
     5881 cacgactatt atatgttttt gcgtgaaggg ctgattcagg gggcgggtga ttataccgat
     5941 gccgctgcct ttactcttgt tgctgagaat ttggataaga tggccattcg taaaagacat
     6001 gccatcactc cggatattcc caaacggttt gtcaatttgt ttaaaagtct gttgatatgc
     6061 aagtaacttc acaaagagct tcggccatat tgtataatta tctgtctggc aaccattttg
     6121 ataaaccgtt cttattgccg gcaaatgtgt gtcctgtagt gcccctgtcg tttatgaaag
     6181 caggtgtcgg ttttgagttt atagacatag atgaaagcca tgccatgtca accgagaaat
     6241 gtttgacagc tatagaggcg ggaaaatatt ccggtcttgt atttgtgcat gcctacggga
     6301 aaaagtatga caacaaagaa ttttaccggg cagtgaaaag tctcgatcca aatctttgta
     6361 tcattgatga ttgttgcttg tgcattcccg aattggcaga ttccttgcct gaaaatgtgg
     6421 atctctgcct ttacagtacc ggatatgcca aattcataga actttcctat ggtggctatg
     6481 caagttttag ggggggggta cgaagttgtt gattatcagt atgatagcat tagtgaacaa
     6541 aagcattcgg tatatataag gaaatgtctc ctggagaatg tcagatatat gcttccggct
     6601 gactatcctt ggctggacgc ctcaaatttg caaatgaccg atgaggaata ttttgacatc
     6661 attgaaagaa agctcccaaa agtgattgcg gaaaaagaga aaataaacaa gatatacagg
     6721 aatctgcttc ctgaatcgat tcagatggga gatgatttcc agaactggag gttcatgatt
     6781 gtcatcgaga accggcagaa ggttcttgac gcaatattca aggccggtct gtttgccggg
     6841 actaatttcc cttcggtttc atacatgttc aaaggtgttt cttctcctgt tgcggaagtg
     6901 gaggcgaagc atatcgtcaa tttgtttaat gatttccggt tcagtgaagc acaggcaaga
     6961 aagatctgtg atgtgataaa ttcggttata tgaataaaag attattgata ctgggcgcag
     7021 gtgaaatgca ggttcctgtc atccgaaagg cgaacgatat gggattgcat accatagtcg
     7081 cagatatgga tgcgaatgct ccgggaatgg ggtacgcctc ggaaccggtt cttgtcagca
     7141 cgatggataa ggaaggtgtt ttggaatgtg ccaaacgtca ctctgttgac ggcatactta
     7201 ctacaagtga cgcgcctgta aatgtggttt cctatgtcgg ggaacagctg gggcttccgt
     7261 ccatgtccac tgaggtcgca aaaatctgta caaacaaata cttgcagagg gaaatgtttg
     7321 cggccaacgg gattgatgta ccatttttca tgctttgtga taaagatacg gacttgggca
     7381 cattgcaaga ttatccatat attgtcaaac cggtagattc ctctgcaagc cgcggagtaa
     7441 aaaaggttac aaatcataaa gaacttgtac ttgctttttc cgaagctctc ggttattccc
     7501 gtaccggaaa ggccattgtc gagggcttta taacaggccg tgaattcagt gttgaaacat
     7561 atacgcaaaa caataaaact accgttgtca ctattacgga gaaactttgt atcggtgagg
     7621 cagaaggctt ctttgttgaa gatacgcaca ttgaaccggc gcggataacg aaacaggagt
     7681 gggagctggt ttcggagacc gtatcaaaag cactttgcct gattggactt aataattgcc
     7741 cctcgcatac agaaataaag ctgaatgaat cgggcgctta tatcatagaa attgcttgcc
     7801 ggcttggagg agattatata acctctgatt tggttccatt gtcaaccggg atagatatgc
     7861 tgagaaatct ggtgaactgt tctcttggtt tgcccgttga tgtccttcgc aaacatgaaa
     7921 aatgctcagc ggtacagttc cttaatccgc tcaactatca gcgttgtgtg gattttctaa
     7981 gctcttcccg gtcatcggct gtttttcggt ctgaaataag accttattct gaaaaaaaaa
     8041 taaaaaactc tttagaccgt ttagggtata tcatacttca gactgatagt atggaagagc
     8101 ttgaaagtat tctaaggacg attaaatagt aaagacatga gagataagtg tatgattgtg
     8161 gctgagatgt ctgccaacca taacggtaag aaagaaacag ccattgaaac cgtcagggct
     8221 gcaaaacgtg ccggagccga tgccgtcaag ttgcagacct atcgggctga taccattacg
     8281 cttcgctgtg acaagcctga ttttataatt aatgaaggct ctatatggga cgggcaatat
     8341 ttttatgatt tgtatgaaca ggcttatact ccttgggagt ggcatgaaga gttgttccat
     8401 gtggccaagg aagaaggact gatctgtttt tcttctcctt ttgataagac agccgtcgat
     8461 atgcttgagg ctttggactg tcccgtttat aagatagctt ctttcgaaat tacggatatt
     8521 ccattgatag aatacgcggc ttcgaagcat aagccgatgg tacttgctac aggcatagcc
     8581 accgaagaag atattcaatt ggctgttgaa gcttgccgca gaatgggaaa taatgatatt
     8641 acggttctta agtgtacctc ttcttatccg gctccagttg aggaagccaa tctttgtatg
     8701 attcgtgatt tggcagaacg tttccaggta aaaagtggac tttccgacca taccctgggg
     8761 agtgtctctc ccattgtggc ggttactcaa ggtgcgagta tgatagaaaa gcactttatt
     8821 ttgaatcgtt ccatcggtgg tccggattgt tctttttcta tggaagagaa agattttgcc
     8881 caaatggtaa aagatgtgcg catggctgag ttatctttgg ggaaaacgac ttacgaattg
     8941 acggagaaaa tgagaggtag ccgttccgca tcacgttctc tctatgtggc cgaggatatg
     9001 aaggccggag aagtgattac ggagcggaac gttcgctccg tccgtccggg cttcggcctg
     9061 caccccaaat atctgaaaga tatattggga aagaacgtga accgggattt ggagaaaggg
     9121 acgaggtttg cattggagta cgtgaatggt tagcctgata aaaataagaa gataaaatag
     9181 aggtctggaa tttatttttc tatctttgtt cgtaggtaat ggatatggaa aagttgatta
     9241 ctttaggttc tgaaatataa agactcaaat aaaggattat agggatcctt ttacagcccc
     9301 ctatactcct tttccgcatc gaagcacgga cacgctttcg tcggattcaa gtcatggtgc
     9361 cccacaatca gcgcccgtgg aaagatacgc ttcaactcac gtagcagtgc cagtaacgaa
     9421 gccttctgtt ccaatgtacg ggtatcggca ggaaaacttg cagcatccag tcctccttca
     9481 taacagatgc cgatagaatg gcggttgtga ttgaggcaat gcgcacctat tttttccaac
     9541 gggcggccgc ggtgtatttc gccgttgcgg gtcagataga aatgatagcc gatgtcacgg
     9601 aagccgcggt ggtggatgtg gtcgcggcgg caatcctcaa agcccagggc cacgccttga
     9661 ggcgtggctg agcaatgaac aatgagcagg gtaatcgtac gcatggctat ttgcaagcgc
     9721 ccagacctaa agctcccgct atggcggtag ctacggtgat gattactttg aggacaatgc
     9781 cccacacgga ttttgacttt ttgtcttcac tcatgatgat tggtaattga taattagtaa
     9841 ttagtaattt gtaattattc tcatcctaac ggattctcgc cctgattgcc gtcacttcct
     9901 ccggaaccgc cgtcggaacc actgccatcg ggagcttttc cgcctacggt gtacagggaa
     9961 gattccttca gctgtccatc caggttgatt tgggcattac tcagttcgcc ggtggcacgg
    10021 gcgcggagct tcagcccctt cacgttgttg gccagcgaga agtcggcagc ggattgcgcc
    10081 cctttcttgc tgacgattcc tacggagaag atggcaaggt catccagttt cacgttcttg
    10141 ccgtccagaa tcaattcttt ggtgcaggaa accatgtctg ccagtacccc cttgatgaca
    10201 ccactcgaat agggggtgtt gtgattggac atgtgcttgg ccaatttttc gatgtcgaag
    10261 gtttcttcga ttacggggcg tgcataccag aggcctttca gtgggctgtc ttcgcccgtc
    10321 acttgatact ttttgtaacg aatcatacaa ttaaaattta gaagttaaag gataaaaaca
    10381 tttgctgtgt tgaactcaac gatgcaaaga taaggctgtg gatacgggcg tttgtcggtt
    10441 tttgcaggtt ctcgtctgtt tgggtctgtt ttagtcggtt atttacgctt gtaagtttga
    10501 taatatcatg atttatagtt acttttgatg aaatataaat cgtaactgtc aactatggat
    10561 tcttttgtca tacgtacata cgggcgtacc gaattggccc aaatctattg tcccaatctt
    10621 tgtccggagg ctgccttccg caaactgaaa cactggatag acctttgtcc cgatttgcgt
    10681 gacggacttt ccgctttggg cggttcttcc cgttcccgct cttatacgcc tgcccaagtg
    10741 cggctgatag tggctgcact tggagagcct taaacctgag gttggatggc gtaaaggtca
    10801 ggccgggaat cgtaaaggtg aggttggtac acttggtaca gaggttcatc catcctttcg
    10861 cctcacacac atacgcgtgc gtgaagcgaa gtgaatgtca gacttttggt ttccggtagt
    10921 ttcccttgcc atctacattt tccaccagcc cgtgtttctg catacgtttg agccaggtgg
    10981 aggcggtttc cgatttgatg cccatctctc cggctttctg caggaaagag gcccgtgtga
    11041 attcttcttc catgctgtct accagtgcat cccggtcggc attgccgcgg cttgtcactt
    11101 cggtgttggg caggaaggag aggatatggg tggtatgccg ataaaggctt tcggccagtg
    11161 agagtacggc atgaaagtca tcggaagcaa taaggagatt ccatcggctg acaatgtggt
    11221 ctttcagatt gtctgtggct gtgtgagggt cgggcgacac gtaaggcgag gcggtgattt
    11281 ccccttgttc cattgcgcgg agcatggcca ccacttccat gatgcggcag atgttgatgg
    11341 ccagacgtgc cacgctgctt gacatctcgt ttccgttggc tagtccggag cgtacgaaaa
    11401 gccgggagaa gagccggttg aattcatctt tctgtccgtc cgtaaggtga agggtgaata
    11461 ttccgttcat gacaatggtt ttcagtttgt ccttccattc catgcccaga gccttgaagg
    11521 tatcttcaag atcgctgtca ttgcggtcga actggttttg ccaatgatgt atggcaggca
    11581 tgtagtagaa tacctggcga gaaaagagcc cgttctcagc agtgggaatc agtggtttca
    11641 cttgtgaggg ggtgcctgac agaagtacgg aaagataagt tttctttacc tctcggtatt
    11701 cgtggtcggt gcgccggttg taggacagtc ggtcgtggtc gaaggctttg cgcatggtgt
    11761 cgctccagtg tccgtattcc gaaccgatgg cggtggagat ggtgtcggct tcgctttcgc
    11821 atatcagtcc ggtaccgtcg gagtccatca ggttttgcag gatgccggtt ccggtgttgt
    11881 tgcccgagat gaggaacatc ttgttgagag gcattacggg agtctccgtt tttccacgtt
    11941 ccttgcccag tgtgtcgtat tttgcttttt cgcggcggta acatgccatg ctttcgtcta
    12001 cctgcccacg tatttcatcg tgaatgggct cggcaagcag gcgtaccaag gagagcactc
    12061 ctttgccgga tgcaggtagg gctactacaa aggtttgcag gcagggggac atcatttttc
    12121 ctccgtagga acatcggacg tgttttccca tactggcacc caatacggtg atggcaccca
    12181 gtagcagtac atcgtattgg gcgagggagg ttccgcagct catgatgcga ttcaggggat
    12241 aaggccagtg gaggtgttcg tcgaaagtgg gtaatggaga cagtggttca atgcccgatg
    12301 cggactcttc ctcgcgtgcg cgtgtgtgtg aggtagaaga gaggggtgaa ctttgtgtac
    12361 caagtgtacc aatggcgggt gcggcttcat gctgaatctt cacgccgcaa agctcggcca
    12421 gatgaaaggc ggttcctaga tgcacgtcgt tacggccggt cttcaaggca ttgctgaaga
    12481 gcttgtcggc tgcccgtcgg tcgtacttgg acgacaggct gcacagactt aaaaaatcat
    12541 gccgtcctgc ttctccgcag tcggtggcaa tggcaaatgc cagttgtata tattcttgat
    12601 aggttggagc aatgtctgct cctgcatttc tgactgcttc ggccagaagg tgcaatgaag
    12661 atagtggttc catcggattt ggtaatttat aattagtaat ttgtagtcgg tgatttgcaa
    12721 tgactcataa ttcgaagttc acaacttttc tgagcagtgc tttcgggtca tggcagagga
    12781 aacaggcgcg tacgaggtct ttccccgaag tgtccactcc ttttccgggt tgtgtgtttt
    12841 ctgcgtcata catgcagtgg acgtagttca tggcccagcg caccgcctcc gtgctgtctt
    12901 ttccgatagg gcagggtaca aaagccttta cacctcgtcc ggtagggctg atgaacacca
    12961 gtaccggtgc gaggtaaggg tctttgaaca gtagttgctt caggcgtccg gcttcgtcag
    13021 gtgagtcgag atggtctacg tccaccacca ccagtccgga gggtagcttt aggcagtcgc
    13081 tccgtcgtcg ggtgaatacg ccgcaggggg tgacgtaggg taaggtttgc tgtttcagca
    13141 tccggcagtt gttatcatcg ccttgtaggg cagcttcgcg gatggcttgt gttagggtga
    13201 tcagccgttt gttggctgtg atgagttggt aaacttcgtt cagttctaaa gtacgcaggg
    13261 gggtaagcgt ggcgcttttc acgattttcc tggtcgctcc gtccttcatc ggtgagatgg
    13321 gtggcatgaa aagcgacatt ttaaaagatt ttggcatatt atacgtttaa atagttggct
    13381 caaaggtatt cattctcttt cgttgaatct ttcccacatg taagaaagat tttaaaggaa
    13441 caaagtaaat aataacaata tataacataa tattctatct aattacttaa aatttatcta
    13501 aatgggcaaa aattttattc acccttcatt gggctttttt atcgagcgaa cgagaaaaca
    13561 gagtggagtc actattgaaa ctctttgcaa ggatttgcat atttctccat ccacgtacat
    13621 agacttaaaa aaaagggtgt aacgcctcac ttagtacata cgaaactctt ctgcgatact
    13681 atatcgatga actggaggaa ctggatgatg acgaaatcag gaaattggct ggggaatggg
    13741 tggaaaaatg gctggaggtt aggaagaagg gggagtggtg attggattgg ttgattatta
    13801 ctgataatta aaggaatcta tataaatgat taattttaca gtaggtccgg tgcaatcttc
    13861 tgatgctgta cgggtcatag gtgccgaaca ggtaccatat ttagaacagc agagttttca
    13921 gaaatgatgc ttgagaatga gcgccttgtt aagaaatttg ctaatgcgac taaagatagt
    13981 aaggttgttt tcatgacatg ttctggctct ggtggtatgg aggctgccat cataaattgc
    14041 cttacgccac aggataaggc tcttgtaatc aatggtggta gctttggtga gcgttttgtg
    14101 gaattgctta cccttcataa aattcctttt acggaaatta agcttaagta tggtagagct
    14161 ttgaagcctg aacatcttgc tgaatatgag agcaagggtt acactacttt ccttatgcag
    14221 aagcacgaaa cttttacggg ggtacattac gatatcaatc ttgtttctga tttttgcaaa
    14281 cgtaataatt gtttcttgat tgttgatata atctctacct tcctttgcga ttcatttgat
    14341 atggtggcaa tggatgtagg ggtgatgatt actggaagtc agaaggctct tgcttgcgct
    14401 ccgggtattg cagttatgct tcttgctcct tcggctatta aacgtataga aaaggtccaa
    14461 tgttgctgtc agtatcttga tttgaagctt gctcttaaaa atatggagag agggcagact
    14521 ccttgtactc ctgctgttgg tatccttcgt caaattaatg tccgtttaaa agaaattgag
    14581 tctgcaggtg gtgcggaggt ggagattgcg cgttgtgcag aattggctaa gtattttcgt
    14641 gataagcttg ttaagaataa tcttccactc ttttgactta tcgtcaggtt ggaacaaata
    14701 gctttacagt taagtattat gttgagaagt ttattcttga catgaatacg atgaagataa
    14761 ttagggttga cgagtatcgc gacaaaaaga agattaatcg tcccgcaggt tcgttattct
    14821 ctgtagatgg agaaatttat cgagtggcac aaaaatgcag tcgtgcatat ggagagtcga
    14881 tctttgtgta taagacaagt aagaattttg attttattaa agataaaaag gtagcagaac
    14941 tcactggtca gagtatagtc ctgagtgatg gtagaaagcc gattttgttg cacacttatt
    15001 ctcaagcagg agggattgag gtgattgact atagatgctc tttataataa tttgaaaaat
    15061 gttaaataat aatggcaaag acagtttatc ttggtatgat aggtgatatc atgcatccgg
    15121 gttacattaa catcattaac aaagctactg agtatggcga tgtgataatc ggtttgttca
    15181 ctgataaggc gattgctaac caccgtagac ttccttatct cacttgggag caaagaaaga
    15241 acgttgttga gagcatcagg aacgtatcaa gggtggtccc tcaggatgat tggagctatg
    15301 tctctaatct ccttaagtac aagcctgatt acatcattca tggtgatgat tggcaggtgg
    15361 gtcctgacaa gtatatccgt gatgaggtat tcaaagtaat ggaaaagttg ggtggtgagg
    15421 ttatcgagat tccttacacc caaaacatct ctgcttctgg tatcaaacaa gagattgatg
    15481 ctcttggtgt aactcctcag atgcgtcttt cttctctccg tcgccttatt gcagctaaac
    15541 cgattgtacg tattcttgaa agtcacaatg gtcttactgg cctcatagca gaacatacta
    15601 aggtagaggt gaatggtcag gagcgtgaat tcgatggcat gtgggcttcc tcccttaccg
    15661 actctacctc taagggtaag cctgatattg aggctgtcga tttgactacc cgtctccatg
    15721 acctcaatga tacccttgaa gtaaccacaa aacctgttat cttcgatggc gatactggtg
    15781 gcaagattga acacttcggt tttaccgttc gcacccttga gcgcttggga atctcttgcg
    15841 ttataattga agataaggta ggtttaaaac agaattcact ttttggtact gatgctgtac
    15901 agactcagga tacaatcgaa ggttttcagg ctaaaattcg tgcaggtaag gaagcgcaaa
    15961 ttactcgtga cttcatgatt gtcagccgtt gtgagtctct cattgctggt aagactgtag
    16021 atgatgcttt ggagcgttgt catgcttacg tagaggcagg tactgacggt ataatgatcc
    16081 actccaaaga gaagtctgga gaggacatca aggagttttg cttgcgcttt cgcgagaaga
    16141 atgctcatac tcctatcatc gttgtgccta ctacttataa ccagttcaca gaagaggaac
    16201 ttgctgaatg gggtattaat gtagtgattt atgctaatca catgcttcgt tctgcttatc
    16261 ctgcaatggt taaatgtgca gaaaccatcc tctatactag ccgttcgctt gaagcatctg
    16321 agcagtactg tatgcctatc aaacagattc ttaatcttat tccaggcaca aagaagaagt
    16381 aaacattaat ttcttacccc ttaaactatt ttacaaatgg taagacccga attttttgta
    16441 aatatactca aggaacaagg tatagacttt tatgctggtg ttcctgattc gttgctcaag
    16501 aacatttgtg catatattac cgaccacctt cctgctgagc agaatattat tgctgctaac
    16561 gaaggagggg ccatgggtat tgctgtaggt tatcatttgg caacaggtaa ggtgcctgta
    16621 gtttatatgc agaactctgg tgaaggcaat atcattaatc cgtttgcctc tcttaccgac
    16681 aaggacgttt ataacattcc tgtgctcctc gttatcggtt ggagagggcg ccctggagtt
    16741 cacgatgaac ctcagcatgt gaagcaaggt aaggtgacaa tcggtttgct taataccatg
    16801 ggtatcaact atgctattct gccaaaggat gaagagggag ctgcaaagca gataaaaata
    16861 gctgtcgact tcatgaaggc aaccaacgag tgctatgccc ttgtgataga gaaggatact
    16921 ttcgatacct ataagcttca gagcgttgag gtaaacgaac tggcaatgtc tcgcgaagag
    16981 acgattcaga aggtggcttc aaacattgaa gataatgctt gtatcgtatc aactactggt
    17041 atgatttctc gcgagctctt tgaggcacgt actgcttgga gccaaggtca tgaacgtgat
    17101 ttccttactg taggggcgat gggccatgct tcccagatag ctctcggcat agctctccaa
    17161 aagcctgagc gtcgagtata ttgttttgat ggtgatggag ccagcatcat gcacatgggt
    17221 aatatggcta ttacagccag catgaaatgc aagaattatg tgcacattgt gttcaacaat
    17281 ggcgcacacg attctgttgg tggtcagcct actgttggtc tcaagattga tttttgtgca
    17341 attgctcaag ctgtaggcta caaggctgct tatagtgtag aaactatgga ggcacttgaa
    17401 gcaaaacttg cagaattcaa gaacgcagaa ggtcctgttt tccttcagat ttgcgtaaaa
    17461 aagggaaacc gcaaggacct tggccgtcca actacaactc ctattcagaa caaagaggct
    17521 tttatggaat ttcttaacaa gtaaagtatg aaagtaattc tgtttgctga tatacacgcc
    17581 aatctttctg cttttgaggc ggttctagct gatattgaga aacactatca gccagatgcc
    17641 atgattagtc taggtgactt tatcgactat ggtatgcgtt caaatgaaat tattgaacgt
    17701 atacaaactg ttaatattcc attacttgcc aatttgaagg gcaatcacga gaaggctttg
    17761 attgatgggg aactctcatg tttctcttca gaaagagctc gtgtgatgtc caaatacaca
    17821 agaaaccatc tcactcagac atctattgat tatataagca atgtgatgca agagccaatg
    17881 caagagttgg aaattggtgg taagaaagta cttcttttac atggaactat tgatgatccc
    17941 tattggggaa aactgactcc agcaaaagtg gaagatgaaa agtatcagga ttttgactac
    18001 gtattgagcg gtcacattca tcaacctttt aagatagatg tattcttcaa agttgacaat
    18061 ccaatcatgc gcaatcagaa acgtacgact tttatcaacc caggttcagt tggacaacct
    18121 cgcaatcaga atccatatgc acaatatgtg tatatcaatt ttaaaacggg ggaaacccat
    18181 ttcaatgcag ttccttacga tattgaagct gaacaatctc ttttccccaa agagatagat
    18241 actttttaca gcgaacgatt aaaatttgga atataaatga agaacttata tgtaataagt
    18301 ggtgttactg gcatgacggg tagtgaactg tctcgtcagt ttgtttctca gggtcatacg
    18361 gtaatcggtt tcgacaactt ctttgcaagt tctattgata ccgttaaaga cattattgac
    18421 aatccctcgt tcatcttcta taattacgac attaacaaag tcgctcagat ggatgaagta
    18481 tgcgataagg cgaaagaact caaaattgag tgcgatggcc gtctggtgtt tatcaattgt
    18541 gctgctgttg tccatacaaa gcatttctat gaggtagaga gtacttttca gactaacgtc
    18601 cttgctatga aggatttctt ggagcgtgcc atttctatga gggctgatac ttacattaat
    18661 tgttcaactt cggaggttta ctcaatgcag tcttggaatg agaatggcgg tgtgaaagaa
    18721 tctgattatt tggcaatgtc aacagcggaa catagccaac gtacaagtta tgcttgcggc
    18781 aagttgatga ctgaattctt tatgaaagat gctgttggca agggacgaat taaaggttgt
    18841 tctattcgct ttgctaatgt atatagcagg cacgagcgtt ttgcagagca cattatccct
    18901 catatcattg ataatctgct tgaaagccat accgtaaccc ttcttgaaaa ctcgaaggtg
    18961 aacaaacgta ccttccttca taatattgat agctgtcgtg ccgttatgga gctcatcgct
    19021 tctgaggatg ctcttgatgg tactgtttat aatgtggcta ctgaagagga aattgccatt
    19081 attgatctag tcaagacgat tgcaataaaa atgggcatca acgatgtgga tatccgtttc
    19141 gaaggttacc gaaagtctga tcctgagcgt cgattgctca atacggacaa gattcgtacc
    19201 cgtactagct ggaaacctat catcactctc gatgaaggcc tcacgatgtg tgtaaatagt
    19261 atcaagaaat gaaatatttg attataactg ttgctggaac ggctacgcgt tttaatcgcg
    19321 acactaagga agaaaccctc aaatgcttgt attataccga tgaacctcaa tacgctcttc
    19381 ttgctcaatt gctgaagaat tgtggtgagt acgataaata tatccttgtg gggggctacc
    19441 tttatgagaa gttgggaaga tttgtaaaga acgaactctc tggttatggc aaaaaaaaag
    19501 aacttgttta caacgagcat ttcaaagact atggctccgg ctacagttta tacaaaggta
    19561 tagaggcaat aaaggaggca ggtgatgtga ctttcgtaga aggcgacttg ttctttatgg
    19621 ctacagattt caggcaagtg tataattcgc caaagagtgt gattaccatt aaccgagaac
    19681 caatctactc gaataaggca gttgcgttat acattaacgt tgatggcaaa ccaaggtatt
    19741 tatatgatac gaatcatcag acattaactg tatcagagcc attcaaggca atcttcaaca
    19801 gtggtcagat gtggaaattt tcttcatctg agaggctttt gaagactgtt gattcgctta
    19861 caaaagaaca acttcaaggt actaatcttg aaataattca ggcttacttt agtgatatga
    19921 atagtgaaga gtatgatgta gtgactttca ctgactggtt caactgcaat actgttgcag
    19981 attatgatat tgtaagaaaa ttgatgtaaa aatgaatatg gctgtattag aaagagatta
    20041 cagaatagat ggaataaagt ggttgctcat tgtattagtt acattcggtc atgtaataga
    20101 acctgcttta agcaatccta ttgccaataa gctctattct ataatct
//
